TDMS Study 05132-06 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
TETRAFLUOROETHYLENE (TFE)
NTP Experiment-Test: 05132-06 Report: PEIRPT09
Study Type: CHRONIC Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 116-14-3
Lock Date: 10/14/92
Cage Range: All
Reasons For Removal: 25008 Accident 25022 Accidently Killed
25003 Moribund 25019 Moribund Sacrifice
25020 Natural Death 25006 Terminal Sacrifice
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 002 CONTROL
Include 004 312 PPM
Include 006 625 PPM
Include 008 1250 PPM
Include 001 CONTROL
Include 003 312 PPM
Include 005 625 PPM
Include 007 1250 PPM
Page 1
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 4|
DAY ON TEST | 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 1| 6| 6| 4| 6| 6| 6| 6| 8|
| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 1| 2| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + + A + + + I + + M + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Mesothelium, Inflammation, Chronic | |
Active | 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelium, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Mesothelium, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + A + + + + M + + + + +|
Mesothelium, Inflammation, Chronic | |
Active | |
Peyer's Patch, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + A + + + + + + + + + +|
Perforation | |
Mesothelium, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + M + + + + + + + + + +|
Mesothelium, Inflammation, Chronic | |
Active | 1|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X |
Hematopoietic Cell Proliferation | 2|
Infarct | 4 3 |
Infiltration Cellular, Mixed Cell | 1 1 3 1 |
Inflammation, Suppurative | 3|
Mixed Cell Focus | X |
Necrosis, Coagulative, Multifocal | 1 1 |
Serosa, Fibrosis | 3|
__________________________________________________________________________|
Mesentery | + + + + +|
Angiectasis | |
Fat, Necrosis | 3 3 3 3 |
Mesothelium, Inflammation, Chronic | |
Active | 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Chronic Active | 3|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 4|
DAY ON TEST | 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 1| 6| 6| 4| 6| 6| 6| 6| 8|
| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 1| 2| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 2 3 2 2 2 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Epithelium, Hyperplasia | 2 4 |
Serosa, Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | + |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 1 1 1 2 2 2|
X-Zone, Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + + M + + + + M + + + + + + + + + + M M M + +|
__________________________________________________________________________|
Pituitary Gland | + I + + + + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Congestion | 3 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 1 |
Ultimobranchial Cyst | X X |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + M + M + + + + + + + + + + + + M|
Infiltration Cellular, Mononuclear | |
Cell | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + M|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 4|
DAY ON TEST | 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 1| 6| 6| 4| 6| 6| 6| 6| 8|
| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 1| 2| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | X X X X X X X |
Inflammation, Chronic | 3 |
Metaplasia, Osseous | 3 |
Pigmentation, Hemosiderin, | |
Cholesterol | |
Polyarteritis | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic Active | 3|
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 2 2 2 3 2 3 2 1 2 2 2 2 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 3 4|
__________________________________________________________________________|
Lymph Node | + |
Pancreatic, Hyperplasia, Histiocytic | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + M + + + + + + + + M + + + + M + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3|
Inflammation | 3|
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + M + + + + M + + + M + M +|
Hyperplasia, Lymphoid | 2 3 |
Inflammation | 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + I + + + + + + + + + + + + M + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Histiocytic | |
Hyperplasia, Plasma Cell | 3|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + M M M + M M M + + + + + + + M + + +|
Hyperplasia, Lymphoid | 3 3 |
Hyperplasia, Plasma Cell | 3|
Inflammation | 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 2 1 1 1 2 2 4|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + I|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 4|
DAY ON TEST | 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 1| 6| 6| 4| 6| 6| 6| 6| 8|
| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 1| 2| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Mineralization | 1 2 2 2 2 1 2 1 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hemorrhage | 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Mononuclear | |
Cell | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Mononuclear | |
Cell | 4 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6| | |
DAY ON TEST | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6| | |
| 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | L |
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + M + + + A + + + | 42 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Infarct | | 1 3.0|
Mesothelium, Inflammation, Chronic | | |
Active | 1 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Mesothelium, Inflammation, Chronic | | |
Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Mesothelium, Inflammation, Chronic | | |
Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Mesothelium, Inflammation, Chronic | | |
Active | 1 | 1 1.0|
Peyer's Patch, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Perforation | X | 1 |
Mesothelium, Inflammation, Chronic | | |
Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Mesothelium, Inflammation, Chronic | | |
Active | 1 | 2 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | | 1 2.0|
Clear Cell Focus | | 1 |
Eosinophilic Focus | X | 5 |
Hematopoietic Cell Proliferation | 1 1 | 3 1.3|
Infarct | | 2 3.5|
Infiltration Cellular, Mixed Cell | 1 1 2 1 | 8 1.4|
Inflammation, Suppurative | | 1 3.0|
Mixed Cell Focus | X X | 3 |
Necrosis, Coagulative, Multifocal | 1 3 | 4 1.5|
Serosa, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Angiectasis | 3 | 1 3.0|
Fat, Necrosis | 3 3 3 | 7 3.0|
Mesothelium, Inflammation, Chronic | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6| | |
DAY ON TEST | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6| | |
| 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | L |
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Fibrosis | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation, Chronic Active | 1 2 | 3 2.0|
Acinus, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Mononuclear | | |
Cell | 2 2 2 2 2 2 2 | 19 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Ulcer | | 1 2.0|
Epithelium, Hyperplasia | 2 2 | 4 2.5|
Serosa, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Serosa, Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Dysplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cardiomyopathy | | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | | 1 2.0|
Capsule, Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 45 2.0|
X-Zone, Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M M M + M M M M + M M + + + + M M + + | 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Pars Distalis, Congestion | | 2 3.0|
Pars Distalis, Cyst | X X | 3 |
Pars Distalis, Hyperplasia | 1 2 | 6 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Focal | | 1 1.0|
Ultimobranchial Cyst | | 2 |
Follicle, Cyst | X X | 2 |
Follicular Cell, Hyperplasia | 2 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6| | |
DAY ON TEST | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6| | |
| 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | L |
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + M + + + + + + M + + + + + + | 42 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Atrophy | 2 | 2 2.0|
Cyst | X X X X X X | 13 |
Inflammation, Chronic | | 1 3.0|
Metaplasia, Osseous | | 1 3.0|
Pigmentation, Hemosiderin, | | |
Cholesterol | 3 | 1 3.0|
Polyarteritis | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Dilatation | 2 3 3 | 3 2.7|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 3 2 2 2 3 2 | 23 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia, Neutrophil | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 5 |
Pancreatic, Hyperplasia, Histiocytic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M + + + + + + + + + + + I + M + + + | 40 |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 3.0|
Inflammation | | 1 3.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + M + + + + M M + + | 39 |
Hyperplasia, Lymphoid | | 2 2.5|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + I + + + + I + + + + + + + + + + + | 43 |
Hemorrhage | 3 | 2 2.5|
Hyperplasia, Histiocytic | 3 | 1 3.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + M + M M + M M + + I M M + M + M + + + | 28 |
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6| | |
DAY ON TEST | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6| | |
| 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | L |
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Plasma Cell | | 1 3.0|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hematopoietic Cell Proliferation | 1 2 3 3 1 2 3 1 | 18 2.1|
Hyperplasia, Lymphoid | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + | 46 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Compression | X | 1 |
Mineralization | 1 2 2 1 2 2 1 | 20 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Congestion | 3 | 2 3.5|
Hemorrhage | | 2 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6| | |
DAY ON TEST | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6| | |
| 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | L |
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Hyperplasia, Lymphoid | | 2 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|
DAY ON TEST | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|
| 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
312 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + A A + + + + M A + + + + + A + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + A + + + + + A + + + + + + A|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + A A + + + + + A + + + + + A + + + + I + A|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + A A + + + + + A + + + + + A + + + + + + A|
Hemorrhage | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + A + + + + + + A + + + + + A + + + + + + A|
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 1 3 2 |
Eosinophilic Focus | X X X X X X X X X X |
Fatty Change | 3 4 |
Hematopoietic Cell Proliferation | 2 2 1 1 1 2 3 1 |
Infiltration Cellular, Mixed Cell | 4 1 3 |
Necrosis, Coagulative, Multifocal | 4 2 4 4 2 3 |
Centrilobular, Necrosis | 2 |
Serosa, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Cyst | X |
Fat, Hemorrhage | |
Fat, Necrosis | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 2 1 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | |
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 1 2 2 2 2 2 2 |
Capsule, Mineralization | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|
DAY ON TEST | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|
| 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
312 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + I + + + + + + + + + + + + + + + + + + I|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M M + + M + + M M M M + + + M + M + + M + M M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + I + + + M + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 1 |
Ultimobranchial Cyst | |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + M + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | |
__________________________________________________________________________|
Ovary | + + + + + M + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | 2|
Cyst | X X X X X X X X X X X X X X |
Pigmentation, Lipofuscin | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Inflammation, Suppurative | 2 |
Endometrium, Hyperplasia, Cystic | 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Erythrocyte | |
__________________________________________________________________________|
Lymph Node | |
Iliac, Angiectasis | |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Inflammation, Chronic Active | |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hemorrhage | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + I + + M + M + + M M + + + + + + + + M + M + M|
Hemorrhage | 2 |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + I + M + M + + + + M + + M + M + + M M M + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|
DAY ON TEST | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|
| 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
312 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + I + + M + + + M + + + + + + + + + + M + + + M +|
Hemorrhage | 3 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 2 2 |
Inflammation, Chronic Active | 2 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + + M M + + + M M + + M + + + + + + + + + + +|
Hyperplasia, Histiocytic | 2 2 |
Hyperplasia, Lymphoid | 2 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 3 2 2 2 2 2 4 3 3 3 3 3 3 2 3 |
Pigmentation, Melanin | 2 |
__________________________________________________________________________|
Thymus | + + + + M M + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture Healed | X |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | |
Mineralization | 2 1 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Pigmentation, Hemosiderin | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Interstitium, Infiltration Cellular, | |
Mixed Cell | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Respiratory Epithelium, Cytoplasmic | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|
DAY ON TEST | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|
| 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
312 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alteration | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + + + + + |
Hyperplasia | 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct, Chronic | |
Infiltration Cellular, Mononuclear | |
Cell | |
Nephropathy | 1 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + A A + + + + + + + + + + + + A|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6| | |
DAY ON TEST | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3| | |
| 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
312 PPM | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | L |
| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M A + + + + + A + + + + A + + + A + | 36 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + A + + + + + | 42 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + A + + + + + | 39 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A A + + + + + + A + + + A + + + + + | 37 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + A A + + + + + + + + + + A + + + + + | 39 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | 1 4 2 | 9 2.0|
Eosinophilic Focus | X X X | 13 |
Fatty Change | 2 | 3 3.0|
Hematopoietic Cell Proliferation | 2 1 2 2 1 2 1 1 2 2 1 | 19 1.6|
Infiltration Cellular, Mixed Cell | 3 3 3 3 2 | 8 2.8|
Necrosis, Coagulative, Multifocal | 3 3 3 2 4 | 11 3.1|
Centrilobular, Necrosis | 3 2 | 3 2.3|
Serosa, Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 13 |
Cyst | | 1 |
Fat, Hemorrhage | 2 | 1 2.0|
Fat, Necrosis | 3 3 3 3 3 | 8 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + I + + + + | 47 |
Acinus, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Mononuclear | | |
Cell | 2 1 2 | 6 1.7|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia, Squamous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6| | |
DAY ON TEST | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3| | |
| 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
312 PPM | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | L |
| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cyst | X | 1 |
Capsule, Hyperplasia | 2 2 2 2 2 3 2 3 2 2 2 2 3 2 2 2 2 3 2 2 2 2 2 | 45 2.1|
Capsule, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + M + + + + | 45 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + M + + + M M M M + + + + M M + + + + | 25 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + | 45 |
Pars Distalis, Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Focal | | 1 1.0|
Ultimobranchial Cyst | X X | 2 |
Follicle, Cyst | X X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + + + + + + + + + M + M + + + + M + | 42 |
Infiltration Cellular, Mononuclear | | |
Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Atrophy | 2 3 2 3 | 4 2.5|
Congestion | | 1 2.0|
Cyst | X X X X X X X X X X X X X | 27 |
Pigmentation, Lipofuscin | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Dilatation | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 | 21 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia, Erythrocyte | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 6 |
Iliac, Angiectasis | 3 | 1 3.0|
Iliac, Hyperplasia, Lymphoid | 3 | 1 3.0|
Iliac, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6| | |
DAY ON TEST | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3| | |
| 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
312 PPM | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | L |
| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Hemorrhage | 2 | 1 2.0|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M + + + M + + + + + M + M + + + + | 36 |
Hemorrhage | | 1 2.0|
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + I + + M + + + + + + M + + + + + | 35 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + M + + + + + + + + M + + + + + | 40 |
Hemorrhage | | 1 3.0|
Hyperplasia, Histiocytic | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 2 | 5 2.0|
Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | I + + + + I + I M + + + M + + + + M + + + + + | 35 |
Hyperplasia, Histiocytic | | 2 2.0|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hematopoietic Cell Proliferation | 3 3 3 3 3 3 4 2 2 3 3 2 3 3 3 2 3 3 3 3 | 39 2.8|
Pigmentation, Melanin | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + I + + + M + + + + + + + + + + + + + + M + + | 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + + + + + + I + + + + + + | 46 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Congestion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Fracture Healed | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Compression | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6| | |
DAY ON TEST | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3| | |
| 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
312 PPM | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | L |
| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hemorrhage | 3 | 1 3.0|
Mineralization | 2 2 2 1 2 | 9 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemorrhage | 2 2 3 2 | 5 2.2|
Pigmentation, Hemosiderin | 2 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Interstitium, Infiltration Cellular, | | |
Mixed Cell | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Respiratory Epithelium, Cytoplasmic | | |
Alteration | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 6 |
Hyperplasia | | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infarct, Chronic | 1 2 | 2 1.5|
Infiltration Cellular, Mononuclear | | |
Cell | 3 | 1 3.0|
Nephropathy | | 1 1.0|
Pigmentation, Hemosiderin | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + | 43 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 5| 6| 4| 5| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 5|
DAY ON TEST | 8| 6| 1| 5| 1| 6| 3| 8| 4| 9| 6| 7| 3| 6| 4| 8| 6| 9| 3| 0| 2| 3| 1| 5| 9|
| 0| 9| 9| 5| 5| 9| 1| 1| 1| 2| 7| 8| 0| 6| 1| 0| 7| 5| 0| 8| 9| 5| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + A + + + + + M + M + + + + + + A A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + + + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + A A + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + A + + + + + + + + A A + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + A A + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 2 1 4 |
Basophilic Focus | X |
Eosinophilic Focus | X X X X X X |
Hematopoietic Cell Proliferation | 4 3 1 1 2 2 1 |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Mixed Cell | 3 1 |
Necrosis, Coagulative, Multifocal | 4 4 3 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Hyperplasia, Lymphoid | |
Mineralization | |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A A + +|
Fibrosis | 3 |
Inflammation, Acute | 3 |
Acinus, Atrophy | 3 3 4 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 3 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2 3 3 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 5| 6| 4| 5| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 5|
DAY ON TEST | 8| 6| 1| 5| 1| 6| 3| 8| 4| 9| 6| 7| 3| 6| 4| 8| 6| 9| 3| 0| 2| 3| 1| 5| 9|
| 0| 9| 9| 5| 5| 9| 1| 1| 1| 2| 7| 8| 0| 6| 1| 0| 7| 5| 0| 8| 9| 5| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
X-Zone, Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Parathyroid Gland | + M M M M M M M + M M M M + + + + + M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + M + + M + + +|
Pars Distalis, Hyperplasia | 1 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + +|
Polyarteritis | 3 |
Ultimobranchial Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M M + + + + + M M + + + M + M + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 |
Congestion | 3 |
Cyst | X X X X X X X X X |
Hemorrhage | 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + A A + +|
Dilatation | 3 |
Inflammation, Chronic Active | |
Necrosis | |
Endometrium, Hyperplasia, Cystic | 2 2 3 2 2 2 3 2 3 3 3 2 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Erythrocyte | 3 |
__________________________________________________________________________|
Lymph Node | + + |
Axillary, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Lymphoid | 4 |
Lumbar, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + + + + + + + + + + + + + + + M|
Congestion | |
Hemorrhage | 2 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Plasma Cell | 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + I + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 5| 6| 4| 5| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 5|
DAY ON TEST | 8| 6| 1| 5| 1| 6| 3| 8| 4| 9| 6| 7| 3| 6| 4| 8| 6| 9| 3| 0| 2| 3| 1| 5| 9|
| 0| 9| 9| 5| 5| 9| 1| 1| 1| 2| 7| 8| 0| 6| 1| 0| 7| 5| 0| 8| 9| 5| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 3 |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + M + M A + +|
Hemorrhage | 3 3 |
Hyperplasia, Histiocytic | 3 2|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M + M + + M + + + + M + + + + M + + + + M|
Congestion | |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + +|
Hematopoietic Cell Proliferation | 3 3 3 3 3 3 3 3 3 2 3 4 4 3 3 3 1 3 3 4 3 2|
Hyperplasia, Lymphoid | 3 |
Capsule, Hematocyst | X |
__________________________________________________________________________|
Thymus | + M + + + + + + I + + + + + + + + + + + M + M +|
Atrophy | |
Necrosis | 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + M + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 1 1 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 3 |
Inflammation, Chronic | 3 |
Pigmentation, Hemoglobin | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Interstitium, Infiltration Cellular, | |
Mixed Cell | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 5| 6| 4| 5| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 5|
DAY ON TEST | 8| 6| 1| 5| 1| 6| 3| 8| 4| 9| 6| 7| 3| 6| 4| 8| 6| 9| 3| 0| 2| 3| 1| 5| 9|
| 0| 9| 9| 5| 5| 9| 1| 1| 1| 2| 7| 8| 0| 6| 1| 0| 7| 5| 0| 8| 9| 5| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct, Chronic | 2 |
Infiltration Cellular, Mononuclear | |
Cell | 1 2 |
Inflammation, Chronic Active | 3 |
Metaplasia, Osseous | |
Nephropathy | |
Polyarteritis | 2 |
__________________________________________________________________________|
Urinary Bladder | + + I + + + + + + + + + + + + M + + + + A A + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | 2 |
Metaplasia, Squamous | 3 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 4| 6| 6| 4| 5| 6| 6| 5| 5| 6| 6| 5| | |
DAY ON TEST | 6| 8| 6| 8| 4| 1| 6| 5| 6| 5| 3| 7| 5| 5| 8| 5| 6| 4| 4| 6| 6| 5| 5| | |
| 7| 9| 9| 9| 1| 4| 7| 2| 7| 0| 6| 6| 3| 3| 4| 2| 1| 2| 1| 9| 7| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
625 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | L |
| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Gallbladder | + A M + A + + + + A + + + + + A + A + + + + A | 34 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + A + + + + A | 42 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + A + + + + + + A | 42 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + A + A + + + + A | 40 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + A + + + + + A + A + + + + A | 39 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + A + A + + + + A | 39 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + A + A + + + + A | 40 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Angiectasis | 1 2 | 6 2.3|
Basophilic Focus | | 1 |
Eosinophilic Focus | X X X X X X | 12 |
Hematopoietic Cell Proliferation | 1 2 1 2 3 3 | 13 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Mixed Cell | 3 3 2 3 4 2 4 | 9 2.8|
Necrosis, Coagulative, Multifocal | 1 1 4 4 1 | 8 2.8|
Centrilobular, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 7 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Mineralization | 2 | 1 2.0|
Fat, Necrosis | 3 3 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + | 44 |
Fibrosis | | 1 3.0|
Inflammation, Acute | | 1 3.0|
Acinus, Atrophy | | 3 3.3|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Infiltration Cellular, Mononuclear | | |
Cell | 2 1 2 2 2 2 2 | 9 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Tooth | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Polyarteritis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 4| 6| 6| 4| 5| 6| 6| 5| 5| 6| 6| 5| | |
DAY ON TEST | 6| 8| 6| 8| 4| 1| 6| 5| 6| 5| 3| 7| 5| 5| 8| 5| 6| 4| 4| 6| 6| 5| 5| | |
| 7| 9| 9| 9| 1| 4| 7| 2| 7| 0| 6| 6| 3| 3| 4| 2| 1| 2| 1| 9| 7| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
625 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | L |
| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cyst | | 1 |
Capsule, Hyperplasia | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 3 2 3 2 | 47 2.1|
X-Zone, Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + M + + + M + + + M + + M + M M | 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
Pars Distalis, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Polyarteritis | | 1 3.0|
Ultimobranchial Cyst | X X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + + + + + + + M + + + + M + + | 38 |
__________________________________________________________________________|____________|
Ovary | + + + + M M + + + + + + + + + + + + + + + + + | 45 |
Atrophy | 2 3 | 5 2.2|
Congestion | 3 | 2 3.0|
Cyst | X X X X X X X | 16 |
Hemorrhage | | 1 2.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Dilatation | | 1 3.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Necrosis | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 4 3 3 3 2 2 4 | 24 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Hyperplasia, Erythrocyte | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Axillary, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 4| 6| 6| 4| 5| 6| 6| 5| 5| 6| 6| 5| | |
DAY ON TEST | 6| 8| 6| 8| 4| 1| 6| 5| 6| 5| 3| 7| 5| 5| 8| 5| 6| 4| 4| 6| 6| 5| 5| | |
| 7| 9| 9| 9| 1| 4| 7| 2| 7| 0| 6| 6| 3| 3| 4| 2| 1| 2| 1| 9| 7| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
625 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | L |
| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Iliac, Hyperplasia, Lymphoid | | 1 4.0|
Lumbar, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + M M + + + + + + + + A + + + + M | 40 |
Congestion | 2 | 1 2.0|
Hemorrhage | 2 | 2 2.0|
Hyperplasia, Histiocytic | 2 | 1 2.0|
Hyperplasia, Lymphoid | 3 | 3 2.7|
Hyperplasia, Plasma Cell | | 1 2.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + M + + + + + + + + I M + M + M + M + + + | 34 |
Hemorrhage | | 1 3.0|
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + I + A + + + + + + + | 41 |
Hemorrhage | 2 | 3 2.7|
Hyperplasia, Histiocytic | 2 | 3 2.3|
Hyperplasia, Lymphoid | 2 3 4 | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M M + + + + + + + + M + + M + + M + | 35 |
Congestion | 2 | 1 2.0|
Hemorrhage | 2 3 3 | 3 2.7|
Hyperplasia, Lymphoid | 2 2 | 4 2.5|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Hematopoietic Cell Proliferation | 2 3 2 3 3 3 2 3 2 4 3 3 4 3 3 3 2 2 3 | 41 2.9|
Hyperplasia, Lymphoid | 3 | 2 3.0|
Capsule, Hematocyst | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + M M I + + + + + + + | 39 |
Atrophy | 3 | 1 3.0|
Necrosis | 3 3 | 4 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 4| 6| 6| 4| 5| 6| 6| 5| 5| 6| 6| 5| | |
DAY ON TEST | 6| 8| 6| 8| 4| 1| 6| 5| 6| 5| 3| 7| 5| 5| 8| 5| 6| 4| 4| 6| 6| 5| 5| | |
| 7| 9| 9| 9| 1| 4| 7| 2| 7| 0| 6| 6| 3| 3| 4| 2| 1| 2| 1| 9| 7| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
625 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | L |
| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Mineralization | 1 2 2 2 2 1 1 1 | 14 1.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + A + + + + + + + + + + + + + A + + + + + + + | 43 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Congestion | 3 | 1 3.0|
Hemorrhage | 3 2 2 2 | 5 2.4|
Inflammation, Chronic | 1 | 2 2.0|
Pigmentation, Hemoglobin | 3 | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 4 | 2 2.5|
Interstitium, Infiltration Cellular, | | |
Mixed Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + A + + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + A + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
Hyperplasia | 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Infarct, Chronic | | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | 2 2 | 4 1.8|
Inflammation, Chronic Active | | 1 3.0|
Metaplasia, Osseous | 2 | 1 2.0|
Nephropathy | 1 | 1 1.0|
Polyarteritis | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 43 |
Hyperplasia, Lymphoid | 3 3 | 2 3.0|
Inflammation, Chronic Active | | 1 2.0|
Metaplasia, Squamous | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 1| 5| 6| 6| 5| 4| 5| 5| 6| 5| 5| 6| 6|
DAY ON TEST | 4| 4| 6| 5| 8| 1| 0| 4| 8| 8| 5| 0| 3| 3| 2| 4| 5| 6| 6| 8| 4| 8| 8| 6| 6|
| 4| 1| 5| 5| 6| 8| 7| 8| 6| 8| 2| 8| 5| 6| 9| 2| 2| 8| 3| 6| 6| 0| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1250 PPM | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + A + + A + + A + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + M A + + + I + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + A A + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + M + + + + A + + + + + A + + A + + A + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A A + A + + A + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + A A + A + + A + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + A + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X|
Eosinophilic Focus | X X X X|
Hematopoietic Cell Proliferation | 2 1 3 2 2 2 2 1 1 |
Infarct | 4 |
Infiltration Cellular, Mixed Cell | |
Mixed Cell Focus | |
Necrosis, Coagulative, Multifocal | 2 2|
Thrombosis | 4 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 4 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + A + + + + + + + + + + + +|
Acinus, Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | |
Inflammation, Focal, Suppurative | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + + + + +|
Epithelium, Hyperplasia | 1 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + A + + +|
__________________________________________________________________________|
Tooth | +|
Dysplasia | |
Peridontal Tissue, Inflammation, | |
Suppurative | 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + A + + + + + + + + + + + +|
Degeneration, Fatty | 2 |
Hyperplasia | 2 |
Capsule, Hyperplasia | 2 1 2 2 2 1 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2|
X-Zone, Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + A + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 1| 5| 6| 6| 5| 4| 5| 5| 6| 5| 5| 6| 6|
DAY ON TEST | 4| 4| 6| 5| 8| 1| 0| 4| 8| 8| 5| 0| 3| 3| 2| 4| 5| 6| 6| 8| 4| 8| 8| 6| 6|
| 4| 1| 5| 5| 6| 8| 7| 8| 6| 8| 2| 8| 5| 6| 9| 2| 2| 8| 3| 6| 6| 0| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1250 PPM | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + M + A + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + A + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Congestion | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + I + A + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + M + + + + M + + + M + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + A + + + + + + + + + + + +|
Atrophy | 2 2 |
Congestion | |
Cyst | X X X X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + A + + + + + + + + + + + +|
Dilatation | 4 |
Hemorrhage | 2 |
Endometrium, Hyperplasia, Cystic | 3 3 3 2 1 3 2 3 4 2 3 2 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + + + + + M + M + + M + + + + + M|
Hemorrhage | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M A M M + + + M + + + + + +|
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + A + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + M + M M + + + + M M + + + M + + + + + M M +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 1| 5| 6| 6| 5| 4| 5| 5| 6| 5| 5| 6| 6|
DAY ON TEST | 4| 4| 6| 5| 8| 1| 0| 4| 8| 8| 5| 0| 3| 3| 2| 4| 5| 6| 6| 8| 4| 8| 8| 6| 6|
| 4| 1| 5| 5| 6| 8| 7| 8| 6| 8| 2| 8| 5| 6| 9| 2| 2| 8| 3| 6| 6| 0| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1250 PPM | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 1 3 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | I + + + + I + + + + + + + + M + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Mineralization | 2 2 1 1 1 1 1 2 1 1 1 |
Ventricle, Dilatation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hemorrhage | 4 3 |
Pigmentation, Hemosiderin | 4 3 |
Alveolar Epithelium, Hyperplasia | 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + A + + + + + + + + + + + +|
Inflammation, Suppurative | 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + A + + + + + + + + + + + +|
Metaplasia, Osseous | |
Pigmentation, Hemosiderin | |
Glomerulus, Amyloid Deposition | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + I + A + I +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6| | |
DAY ON TEST | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1| | |
| 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + + + A A A + + + A M M + A A + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + A + + + + + A + + + A A + + | 40 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + A + + + A + + + | 41 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + A + A + + + A + A + A A + + | 36 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + A A + + + + A A + + A A + + | 35 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + A A A + + + A A + + A A + + | 35 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + A + A + + + A A + + A A + + | 35 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Angiectasis | 3 2 3 | 4 2.5|
Basophilic Focus | | 2 |
Eosinophilic Focus | X X X | 7 |
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 | 15 1.9|
Infarct | | 1 4.0|
Infiltration Cellular, Mixed Cell | 2 3 3 | 3 2.7|
Mixed Cell Focus | X | 1 |
Necrosis, Coagulative, Multifocal | 3 4 3 4 4 4 | 8 3.3|
Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Fat, Necrosis | 3 | 5 3.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Acinus, Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Mononuclear | | |
Cell | 2 2 | 2 2.0|
Inflammation, Focal, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Epithelium, Hyperplasia | 1 | 4 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Tooth | + + | 3 |
Dysplasia | 3 3 | 2 3.0|
Peridontal Tissue, Inflammation, | | |
Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6| | |
DAY ON TEST | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1| | |
| 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Degeneration, Fatty | | 1 2.0|
Hyperplasia | | 1 2.0|
Capsule, Hyperplasia | 2 2 2 3 1 2 2 1 2 2 2 2 2 1 2 2 2 3 2 2 | 41 2.0|
X-Zone, Vacuolization Cytoplasmic | 3 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + M M M + + + M + M + + M M M M M + + M | 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + | 46 |
Pars Distalis, Angiectasis | 2 | 2 2.5|
Pars Distalis, Congestion | 3 3 | 2 3.0|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 3 3 | 5 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Ultimobranchial Cyst | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + M M + + + M + + + + + + M + + + + + | 39 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + A + + | 46 |
Atrophy | | 2 2.0|
Congestion | 2 | 1 2.0|
Cyst | X X X X X X X X | 18 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Dilatation | | 1 4.0|
Hemorrhage | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 3 3 3 2 3 2 2 3 1 2 | 24 2.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia, Neutrophil | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 6 |
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Hemorrhage | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + M + + + + + + M M + M + + + + + | 38 |
Hemorrhage | 2 3 3 | 3 2.7|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6| | |
DAY ON TEST | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1| | |
| 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + M + + + + M M M + + + + M + + + M M M | 32 |
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + A + + + + + + + M + + + M + + + + + + + + | 43 |
Angiectasis | 3 | 1 3.0|
Hemorrhage | 2 | 2 2.5|
Hyperplasia, Lymphoid | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M + M + + + M + + + + + M + + M + + | 33 |
Congestion | 4 3 | 2 3.5|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hematopoietic Cell Proliferation | 3 2 2 3 2 3 3 3 3 3 3 3 4 3 3 3 3 3 3 4 | 41 2.9|
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | M M + + + M + + + + + + + + M + M + + + + + M | 38 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + + + + + + + M + + + + + + | 46 |
Hyperplasia | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Compression | X | 1 |
Mineralization | 2 2 2 2 2 2 1 2 2 2 | 21 1.6|
Ventricle, Dilatation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + A + + | 47 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hemorrhage | 4 | 3 3.7|
Pigmentation, Hemosiderin | 3 | 3 3.3|
Alveolar Epithelium, Hyperplasia | 2 | 2 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 | 3 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + M + + + + + + A + + | 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6| | |
DAY ON TEST | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1| | |
| 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Metaplasia, Osseous | 2 | 1 2.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
Glomerulus, Amyloid Deposition | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + A + A + + + A + + + M + M I | 37 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 5| 3| 6| 6| 6| 6| 6| 5| 6| 6| 9| 6| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 0| 9| 6| 6| 6| 6| 6| 0| 6| 6| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 2| 4| 5| 6| 7| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + A + A + + + + + + + M + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + I + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + M + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Peyer's Patch, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | X |
Fatty Change | |
Hematopoietic Cell Proliferation | 1 |
Infarct | |
Infiltration Cellular, Mixed Cell | 3 |
Mixed Cell Focus | X |
Necrosis, Coagulative, Multifocal | 2 1 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Granuloma | |
Hemorrhage | 3 |
Inflammation, Focal | 2 |
Epithelium, Hyperplasia | |
Serosa, Inflammation | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 3 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 5| 3| 6| 6| 6| 6| 6| 5| 6| 6| 9| 6| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 0| 9| 6| 6| 6| 6| 6| 0| 6| 6| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 2| 4| 5| 6| 7| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia | |
Capsule, Hyperplasia | 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M + M + M M + + + M + + M M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | A |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 |
Inflammation, Chronic | 2 4 3|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3 |
Hyperplasia | 3 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 1 |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M + + + + + + + M + + + + + + + + M M + M M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + I + + + + + M M M + + + +|
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 5| 3| 6| 6| 6| 6| 6| 5| 6| 6| 9| 6| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 0| 9| 6| 6| 6| 6| 6| 0| 6| 6| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 2| 4| 5| 6| 7| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Histiocytic | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + I + + M + + + M + + + + + + M + + + M + + M M +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 2 2|
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M + M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic | |
Ulcer | |
Prepuce, Acanthosis | 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Mineralization | 2 1 1 2 2 2 1 2 2 2 |
Necrosis, Liquifactive | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 3 1 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 1 2 |
Interstitium, Infiltration Cellular, | |
Mixed Cell | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Respiratory Epithelium, Cytoplasmic | |
Alteration | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 5| 3| 6| 6| 6| 6| 6| 5| 6| 6| 9| 6| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 0| 9| 6| 6| 6| 6| 6| 0| 6| 6| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 2| 4| 5| 6| 7| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | M + |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage | 3 |
Infiltration Cellular, Mononuclear | |
Cell | 4 |
Inflammation, Chronic Active | 4 |
Inflammation, Suppurative | 3 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1|
Renal Tubule, Karyomegaly | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 6| 6| 6| 4| 6| 6| 6| 7| 3| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 2| 6| 6| 6| 1| 6| 6| 6| 5| 8| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | L |
| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M M + + + + + + + + + + + + + | 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + | 46 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + | 46 |
Peyer's Patch, Inflammation, Chronic | | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Basophilic Focus | X | 1 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | | 1 |
Fatty Change | 2 2 | 2 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Infarct | 4 | 1 4.0|
Infiltration Cellular, Mixed Cell | | 1 3.0|
Mixed Cell Focus | X | 2 |
Necrosis, Coagulative, Multifocal | 1 | 4 1.8|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Granuloma | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Mononuclear | | |
Cell | 2 2 2 2 | 7 1.6|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Foreign Body | 2 | 1 2.0|
Granuloma | 2 | 1 2.0|
Hemorrhage | | 1 3.0|
Inflammation, Focal | | 1 2.0|
Epithelium, Hyperplasia | 2 2 | 2 2.0|
Serosa, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Tooth | | 2 |
Dysplasia | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 6| 6| 6| 4| 6| 6| 6| 7| 3| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 2| 6| 6| 6| 1| 6| 6| 6| 5| 8| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | L |
| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cardiomyopathy | | 2 1.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Accessory Adrenal Cortical Nodule | 4 | 1 4.0|
Hyperplasia | 2 | 1 2.0|
Capsule, Hyperplasia | 1 1 1 2 1 1 1 2 1 1 2 1 1 | 29 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M M + + + M M M M + + + + M + + | 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + | 47 |
Pars Distalis, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Ectasia | 2 3 | 2 2.5|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 2 | 6 1.2|
Inflammation, Chronic | 3 4 | 5 3.2|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + I + + + + + + + + + + + + + + + + + + + + | 46 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Dilatation | 3 | 4 3.0|
Hyperplasia | | 1 3.0|
Inflammation, Chronic | 2 | 2 2.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 6| 6| 6| 4| 6| 6| 6| 7| 3| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 2| 6| 6| 6| 1| 6| 6| 6| 5| 8| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | L |
| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia, Neutrophil | 3 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Iliac, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + + + + + M M + + + + + M + + + + + + + | 36 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + M + M + + M + + + + + + + M + M + + + | 36 |
Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + | 47 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Histiocytic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M + M + + + + M M M M + + + M + + + + M | 30 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hematopoietic Cell Proliferation | 3 3 1 1 2 1 2 3 3 | 14 2.1|
__________________________________________________________________________|____________|
Thymus | + + M + + M + + + + + + + + + + + + + + M + + | 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Acanthosis | 2 | 1 2.0|
Inflammation, Chronic | 3 4 | 2 3.5|
Ulcer | 3 4 | 2 3.5|
Prepuce, Acanthosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemorrhage | | 1 2.0|
Mineralization | 2 1 2 2 2 1 2 2 2 2 2 1 1 | 23 1.7|
Necrosis, Liquifactive | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + A + + + + + + + + + + + + + | 47 |
Cytoplasmic Alteration | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 6| 6| 6| 4| 6| 6| 6| 7| 3| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 2| 6| 6| 6| 1| 6| 6| 6| 5| 8| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | L |
| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemorrhage | 2 | 6 1.8|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 4 2.0|
Interstitium, Infiltration Cellular, | | |
Mixed Cell | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | 1 | 1 1.0|
Respiratory Epithelium, Cytoplasmic | | |
Alteration | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + | 47 |
Cytoplasmic Alteration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cyst | X | 2 |
Hemorrhage | | 1 3.0|
Infiltration Cellular, Mononuclear | | |
Cell | 2 | 2 3.0|
Inflammation, Chronic Active | | 1 4.0|
Inflammation, Suppurative | 2 | 2 2.5|
Nephropathy | 1 1 1 1 3 1 1 2 1 1 1 1 1 1 1 1 | 32 1.2|
Renal Tubule, Karyomegaly | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
Inflammation, Chronic Active | 4 | 2 3.5|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 5| 5| 6| 5| 6| 6| 6| 0| 5| 6| 0| 5| 6| 5| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 1| 0| 6| 5| 4| 4| 6| 4| 6| 4| 0| 7| 7| 6| 4| 6| 1| 2| 3| 2| 1| 6| 6| 6|
| 6| 4| 9| 6| 1| 1| 1| 6| 1| 6| 9| 0| 5| 3| 0| 4| 9| 6| 2| 1| 5| 4| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
312 PPM | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + + + + + + A A A + + + A A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A A A + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + A A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + A A A + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + A A A + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + A A A + + + + A + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + A A A + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 3 2 |
Basophilic Focus | |
Eosinophilic Focus | X X X|
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | 4 |
Infarct | |
Infiltration Cellular, Mixed Cell | 3 1 2 |
Mixed Cell Focus | X |
Necrosis, Coagulative, Multifocal | 4 |
Thrombosis | 4 |
Bile Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Mesentery | +|
Fat, Necrosis | 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
Epithelium, Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 1 |
Peridontal Tissue, Proliferation | |
Connective Tissue | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | 2 |
Capsule, Hyperplasia | 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 5| 5| 6| 5| 6| 6| 6| 0| 5| 6| 0| 5| 6| 5| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 1| 0| 6| 5| 4| 4| 6| 4| 6| 4| 0| 7| 7| 6| 4| 6| 1| 2| 3| 2| 1| 6| 6| 6|
| 6| 4| 9| 6| 1| 1| 1| 6| 1| 6| 9| 0| 5| 3| 0| 4| 9| 6| 2| 1| 5| 4| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
312 PPM | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + M M M + M + M M M + + M + + M + + + M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
Pars Intermedia, Hemorrhage | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Infiltration Cellular, Mononuclear | |
Cell | 2 1 1 |
Inflammation, Chronic | 3 2 1 |
Inflammation, Suppurative | 3 3 3 4 |
__________________________________________________________________________|
Prostate | M + + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + A + + + + + + + + + + + +|
Dilatation | 4 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + I M + + + + M + + + + M + + M + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + M + + + M + + + + + + + M + M M +|
Congestion | 2 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + I + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 5| 5| 6| 5| 6| 6| 6| 0| 5| 6| 0| 5| 6| 5| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 1| 0| 6| 5| 4| 4| 6| 4| 6| 4| 0| 7| 7| 6| 4| 6| 1| 2| 3| 2| 1| 6| 6| 6|
| 6| 4| 9| 6| 1| 1| 1| 6| 1| 6| 9| 0| 5| 3| 0| 4| 9| 6| 2| 1| 5| 4| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
312 PPM | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 2 3 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M M M + + + + + M + + + + + + M + + + + M + M|
Congestion | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 4 2 2 3 3 2 3 4 3 1 3 2 3 3 3 1|
Hyperplasia, Lymphoid | 2 |
Pigmentation, Melanin | 1 |
__________________________________________________________________________|
Thymus | + + M + M + + + + + + + + + + M + + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 3 3 |
Ulcer | 4 4 3 |
Prepuce, Acanthosis | 2 2 |
Prepuce, Inflammation, Chronic | 4 4 |
Prepuce, Pigmentation, Melanin | 3 |
Prepuce, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mineralization | 2 1 2 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Crystals | |
Hemorrhage | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + A + + + + + + + + + + + +|
Proliferation Connective Tissue, | |
Multifocal | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 5| 5| 6| 5| 6| 6| 6| 0| 5| 6| 0| 5| 6| 5| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 1| 0| 6| 5| 4| 4| 6| 4| 6| 4| 0| 7| 7| 6| 4| 6| 1| 2| 3| 2| 1| 6| 6| 6|
| 6| 4| 9| 6| 1| 1| 1| 6| 1| 6| 9| 0| 5| 3| 0| 4| 9| 6| 2| 1| 5| 4| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
312 PPM | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | |
Nephropathy | 1 1 1 1 1 1 1 |
Renal Tubule, Dilatation | 1 1 1 |
Renal Tubule, Karyomegaly | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + A + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 4| 5| 6| 5| 5| 5| 6| 0| 5| 6| 6| 5| 5| 6| 5| 5| 6| 4| 4| 5| | |
DAY ON TEST | 3| 9| 3| 6| 9| 4| 8| 0| 5| 6| 7| 1| 6| 6| 6| 3| 6| 9| 3| 6| 6| 9| 9| | |
| 7| 3| 7| 2| 3| 6| 6| 8| 2| 6| 7| 3| 6| 6| 6| 7| 6| 9| 7| 6| 3| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
312 PPM | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | L |
| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + A + M + + + M + + A A + + + A + A + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + A + + + + + + A + + + + + + + + + + + + | 40 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + A + + + A + + A A + + + + + + + + + + + | 38 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A + + + + + + A + + + + + + + + + + + + | 40 |
Peyer's Patch, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A + + + + + + A A + + + + + + + + + + + | 39 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | 2 2 | 6 2.3|
Basophilic Focus | X | 1 |
Eosinophilic Focus | X X X | 6 |
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Hemorrhage | | 1 4.0|
Infarct | 4 4 4 4 4 3 | 6 3.8|
Infiltration Cellular, Mixed Cell | 1 3 | 5 2.0|
Mixed Cell Focus | X | 2 |
Necrosis, Coagulative, Multifocal | 4 3 | 3 3.7|
Thrombosis | | 1 4.0|
Bile Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fat, Necrosis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Mononuclear | | |
Cell | 2 2 1 1 1 | 7 1.6|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Ulcer | | 1 3.0|
Epithelium, Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Tooth | | 2 |
Dysplasia | | 1 1.0|
Peridontal Tissue, Proliferation | | |
Connective Tissue | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 4| 5| 6| 5| 5| 5| 6| 0| 5| 6| 6| 5| 5| 6| 5| 5| 6| 4| 4| 5| | |
DAY ON TEST | 3| 9| 3| 6| 9| 4| 8| 0| 5| 6| 7| 1| 6| 6| 6| 3| 6| 9| 3| 6| 6| 9| 9| | |
| 7| 3| 7| 2| 3| 6| 6| 8| 2| 6| 7| 3| 6| 6| 6| 7| 6| 9| 7| 6| 3| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
312 PPM | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | L |
| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cyst | | 1 |
Hyperplasia | 3 1 | 3 2.0|
Capsule, Hyperplasia | 1 1 1 2 2 1 1 1 | 26 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + I + + + + + + + + + + + + + + + + I + + + + | 45 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + + + + + + + + + M M M + M + M + M | 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + M + + + M | 44 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 1 | 1 1.0|
Pars Intermedia, Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Ultimobranchial Cyst | X | 1 |
Follicle, Cyst | X | 1 |
Follicular Cell, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Ectasia | 3 | 2 3.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 2 | 5 1.4|
Inflammation, Chronic | 2 3 | 5 2.2|
Inflammation, Suppurative | | 4 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Dilatation | | 1 4.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 4| 5| 6| 5| 5| 5| 6| 0| 5| 6| 6| 5| 5| 6| 5| 5| 6| 4| 4| 5| | |
DAY ON TEST | 3| 9| 3| 6| 9| 4| 8| 0| 5| 6| 7| 1| 6| 6| 6| 3| 6| 9| 3| 6| 6| 9| 9| | |
| 7| 3| 7| 2| 3| 6| 6| 8| 2| 6| 7| 3| 6| 6| 6| 7| 6| 9| 7| 6| 3| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
312 PPM | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | L |
| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + + + + + M M + + M + + M + + + M + + + | 36 |
Hemorrhage | 2 2 | 2 2.0|
Hyperplasia, Lymphoid | 3 2 | 2 2.5|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M M I + + M M + + + + M + + + + + + + M + | 34 |
Congestion | | 1 2.0|
Hyperplasia, Histiocytic | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Pigmentation, Hemosiderin | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | I I + + M + + + + + + + + + + M + + + + + + M | 42 |
Hemorrhage | | 2 2.5|
Hyperplasia, Histiocytic | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M M + + M M + + + M + + + + M + + + + + | 34 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 3 3 2 2 3 3 3 3 3 2 3 3 3 3 | 32 2.7|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation, Melanin | 1 | 2 1.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + M + + + + + I + + M + + + + | 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + M M M M M M M M M M M M M M M M + M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Chronic | 3 | 4 3.0|
Ulcer | 3 | 4 3.5|
Prepuce, Acanthosis | | 2 2.0|
Prepuce, Inflammation, Chronic | | 2 4.0|
Prepuce, Pigmentation, Melanin | | 1 3.0|
Prepuce, Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 4| 5| 6| 5| 5| 5| 6| 0| 5| 6| 6| 5| 5| 6| 5| 5| 6| 4| 4| 5| | |
DAY ON TEST | 3| 9| 3| 6| 9| 4| 8| 0| 5| 6| 7| 1| 6| 6| 6| 3| 6| 9| 3| 6| 6| 9| 9| | |
| 7| 3| 7| 2| 3| 6| 6| 8| 2| 6| 7| 3| 6| 6| 6| 7| 6| 9| 7| 6| 3| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
312 PPM | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | L |
| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Mineralization | 2 1 2 2 2 2 2 1 2 2 2 | 19 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Congestion | 3 | 2 3.0|
Crystals | 3 | 1 3.0|
Hemorrhage | 1 3 2 | 4 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 4 3 3 | 5 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Proliferation Connective Tissue, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 | 12 1.0|
Renal Tubule, Dilatation | 1 | 4 1.0|
Renal Tubule, Karyomegaly | 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A M + + + + + + + + + A + + + + + + + + | 43 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 5| 4| 5| 6| 5| 4| 5| 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 4| 4| 6| 4|
DAY ON TEST | 3| 8| 8| 3| 4| 9| 5| 5| 1| 6| 6| 9| 6| 4| 4| 5| 7| 1| 1| 3| 3| 3| 4| 5| 8|
| 9| 5| 9| 1| 1| 7| 1| 3| 7| 6| 6| 7| 9| 1| 8| 4| 3| 8| 5| 1| 9| 3| 7| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
625 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 3| 4| 6| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M M + A + M A + A + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + A + + + + + + I + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + M + + A + + + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + A + + A + A + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + A + A + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + A + A + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 4 3 2 |
Basophilic Focus | X X|
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | 2 4 4 |
Infarct | 3 4 |
Infiltration Cellular, Mixed Cell | 2 3 |
Mixed Cell Focus | X X |
Necrosis, Coagulative, Multifocal | 3 3 1 2 2 3 4 1 4 3|
Thrombosis | 4 4 4 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | 3 |
Hyperplasia, Squamous | 4 |
Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
Inflammation, Suppurative | 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 |
Infiltration Cellular, Mixed Cell | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 1 1 2 2 2 2 1 1 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | M M M + M M + + M M + + + + M M + M M I + M + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 5| 4| 5| 6| 5| 4| 5| 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 4| 4| 6| 4|
DAY ON TEST | 3| 8| 8| 3| 4| 9| 5| 5| 1| 6| 6| 9| 6| 4| 4| 5| 7| 1| 1| 3| 3| 3| 4| 5| 8|
| 9| 5| 9| 1| 1| 7| 1| 3| 7| 6| 6| 7| 9| 1| 8| 4| 3| 8| 5| 1| 9| 3| 7| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
625 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 3| 4| 6| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | I + + + + + + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Infiltration Cellular, Mononuclear | |
Cell | |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Atrophy | 2 |
Ectasia | 2 |
Infiltration Cellular, Mononuclear | |
Cell | 2 2 2 1 1 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 4 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Hemorrhage | 2 |
Iliac, Hyperplasia, Plasma Cell | 3 2 |
Iliac, Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + M + + + + + + + + M M + + M M + + + M + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + M M M + I M + M + + + + +|
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 2 |
Pigmentation, Hemosiderin | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 5| 4| 5| 6| 5| 4| 5| 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 4| 4| 6| 4|
DAY ON TEST | 3| 8| 8| 3| 4| 9| 5| 5| 1| 6| 6| 9| 6| 4| 4| 5| 7| 1| 1| 3| 3| 3| 4| 5| 8|
| 9| 5| 9| 1| 1| 7| 1| 3| 7| 6| 6| 7| 9| 1| 8| 4| 3| 8| 5| 1| 9| 3| 7| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
625 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 3| 4| 6| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + M + + M + +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M + + M + M M M + + + M + M + + + + + M + I|
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 1 2 |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 3 2 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Thymus | + M + + + + M + M + + M + + M + + + + + + + M + M|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Inflammation, Chronic | 2 2 |
Prepuce, Ulcer | 4 |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Mucopurulent | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 3 |
Pigmentation, Hemosiderin | 3 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Vomeronasal Organ, Hypertrophy | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 5| 4| 5| 6| 5| 4| 5| 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 4| 4| 6| 4|
DAY ON TEST | 3| 8| 8| 3| 4| 9| 5| 5| 1| 6| 6| 9| 6| 4| 4| 5| 7| 1| 1| 3| 3| 3| 4| 5| 8|
| 9| 5| 9| 1| 1| 7| 1| 3| 7| 6| 6| 7| 9| 1| 8| 4| 3| 8| 5| 1| 9| 3| 7| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
625 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 3| 4| 6| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Degeneration, Diffuse | 4 |
Phthisis Bulbi | 3 |
Retinal Detachment | 4 |
Cornea, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Harderian Gland | + + + +|
Hyperplasia | 4|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic Active | 2 |
Nephropathy | 2 1 1 2 |
Renal Tubule, Dilatation | 1 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Karyomegaly | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 6| 3| 5| 6| 5| 3| 5| 5| 4| 5| 6| 6| | |
DAY ON TEST | 2| 1| 1| 8| 9| 0| 4| 0| 4| 0| 4| 1| 6| 0| 0| 1| 6| 4| 1| 4| 8| 3| 4| | |
| 0| 6| 6| 9| 3| 8| 8| 8| 9| 7| 7| 5| 3| 9| 0| 8| 8| 1| 8| 6| 6| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
625 PPM | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + A + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Gallbladder | A M + + + + + + + + A M A A + A + + + A + A + | 31 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A A A A + + + + + + + + + | 41 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + A A + + + + + + + I + | 41 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + A A A A + A + + + + + A + | 36 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A A + + + + + + + A + A A + A + + + A + A + | 34 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A A + + + + + + + A A A A + A + + + + + A + | 34 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A A + + + + + + + A A A A + A + + + + + A + | 35 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | 3 1 1 2 3 | 10 2.5|
Basophilic Focus | X X | 4 |
Eosinophilic Focus | X X X X | 7 |
Hematopoietic Cell Proliferation | 3 | 4 3.3|
Infarct | | 2 3.5|
Infiltration Cellular, Mixed Cell | 3 | 3 2.7|
Mixed Cell Focus | X | 3 |
Necrosis, Coagulative, Multifocal | 2 3 4 | 13 2.7|
Thrombosis | | 3 4.0|
Centrilobular, Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
Granuloma | | 1 3.0|
Hyperplasia, Squamous | | 1 4.0|
Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Tooth | + + | 4 |
Inflammation, Suppurative | 2 4 | 4 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cardiomyopathy | | 2 1.5|
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + A + + + + + + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 6| 3| 5| 6| 5| 3| 5| 5| 4| 5| 6| 6| | |
DAY ON TEST | 2| 1| 1| 8| 9| 0| 4| 0| 4| 0| 4| 1| 6| 0| 0| 1| 6| 4| 1| 4| 8| 3| 4| | |
| 0| 6| 6| 9| 3| 8| 8| 8| 9| 7| 7| 5| 3| 9| 0| 8| 8| 1| 8| 6| 6| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
625 PPM | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Capsule, Hyperplasia | 1 2 1 1 2 1 1 1 1 1 1 2 1 | 24 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + A + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
Hyperplasia | 2 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M + M + + + + + + M + + I + M + | 29 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + A + + + + + + + + M + | 44 |
Pars Distalis, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + A + + + + + + + + + + + + | 47 |
Ultimobranchial Cyst | | 1 |
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Infiltration Cellular, Mononuclear | | |
Cell | 3 | 1 3.0|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Preputial Gland | + M + + + + + + + + + + + + + + + + + + + + + | 46 |
Atrophy | | 1 2.0|
Ectasia | | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | 2 1 | 7 1.6|
Inflammation, Chronic | 3 2 2 | 4 2.5|
Inflammation, Suppurative | 4 3 4 4 | 7 3.7|
__________________________________________________________________________|____________|
Prostate | + + M + + + + + + + A M A + + + + + + + + + + | 44 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + A + + + + + + + + + + | 47 |
Dilatation | 3 3 | 2 3.0|
Inflammation, Chronic | 3 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + A + + + + + + + + + + + + | 47 |
Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 6| 3| 5| 6| 5| 3| 5| 5| 4| 5| 6| 6| | |
DAY ON TEST | 2| 1| 1| 8| 9| 0| 4| 0| 4| 0| 4| 1| 6| 0| 0| 1| 6| 4| 1| 4| 8| 3| 4| | |
| 0| 6| 6| 9| 3| 8| 8| 8| 9| 7| 7| 5| 3| 9| 0| 8| 8| 1| 8| 6| 6| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
625 PPM | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | | 2 |
Iliac, Hemorrhage | | 1 2.0|
Iliac, Hyperplasia, Plasma Cell | | 2 2.5|
Iliac, Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M + + + + + + A + + + M + I + + M + | 35 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + M + + M M + + M + + M + M + + I + I | 32 |
Hyperplasia, Histiocytic | 2 | 2 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + A + A A + + + + M + + + + | 41 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 3 | 2 3.0|
Hyperplasia, Lymphoid | 2 | 2 2.5|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + I + + + + + + + + + A M + M + + M + + + M | 32 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage | 2 | 3 1.7|
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
Hematopoietic Cell Proliferation | 2 3 3 3 3 3 2 3 3 3 4 2 2 3 3 2 4 3 2 | 41 2.9|
__________________________________________________________________________|____________|
Thymus | + + + + + + M M + + + + A M + M M + + M + + + | 34 |
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | | 1 1.0|
Inflammation, Chronic | | 2 2.0|
Prepuce, Ulcer | | 1 4.0|
Subcutaneous Tissue, Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Mineralization | 2 2 2 1 1 1 | 13 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 6| 3| 5| 6| 5| 3| 5| 5| 4| 5| 6| 6| | |
DAY ON TEST | 2| 1| 1| 8| 9| 0| 4| 0| 4| 0| 4| 1| 6| 0| 0| 1| 6| 4| 1| 4| 8| 3| 4| | |
| 0| 6| 6| 9| 3| 8| 8| 8| 9| 7| 7| 5| 3| 9| 0| 8| 8| 1| 8| 6| 6| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
625 PPM | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
Exudate, Mucopurulent | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Congestion | 3 3 2 2 | 5 2.6|
Hemorrhage | 2 | 2 2.5|
Pigmentation, Hemosiderin | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
Inflammation, Suppurative | 3 3 | 3 2.7|
Vomeronasal Organ, Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Degeneration, Diffuse | | 1 4.0|
Phthisis Bulbi | | 1 3.0|
Retinal Detachment | | 1 4.0|
Cornea, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 5 |
Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cyst | | 1 |
Inflammation, Chronic Active | | 1 2.0|
Nephropathy | 1 1 1 1 1 1 | 10 1.2|
Renal Tubule, Dilatation | 1 1 1 1 1 1 | 16 1.0|
Renal Tubule, Karyomegaly | 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + A + A + + + + + + + + A + | 43 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 3| 4| 5| 6| 5| 5| 6| 6| 6| 5| 6| 5| 6| 5| 2| 5| 5| 6| 6| 5| 5| 6| 5| 5|
DAY ON TEST | 4| 5| 8| 4| 0| 8| 4| 6| 0| 0| 8| 1| 9| 2| 4| 5| 6| 1| 1| 0| 5| 5| 2| 4| 8|
| 3| 6| 3| 3| 8| 3| 1| 6| 0| 8| 9| 3| 9| 9| 8| 9| 3| 8| 3| 0| 1| 9| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 9| 2| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A A + + M + + + + + + M A M A + A M M A M M + A +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + A + A + + A + A + M +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + A + A + + + + A + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + A + A + + A + A + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + A + A + + A A A + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + A + + A + A + + A A A + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + A + A + + A A A + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 3 3 |
Basophilic Focus | X X |
Eosinophilic Focus | X X |
Hemorrhage | |
Infarct | 4|
Infiltration Cellular, Mixed Cell | 3 1 |
Necrosis, Coagulative, Multifocal | 1 4 3 2 3 3 2 |
Centrilobular, Necrosis | |
Hepatocyte, Regeneration | 4 |
__________________________________________________________________________|
Mesentery | + + + |
Angiectasis | |
Fat, Hemorrhage | 2 1 |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + A + + + + + + + +|
Ulcer | |
Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + A + + + + + + + +|
Foreign Body | |
Necrosis | 2 3 |
__________________________________________________________________________|
Tooth | + + + |
Dysplasia | 3 2 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 3| 4| 5| 6| 5| 5| 6| 6| 6| 5| 6| 5| 6| 5| 2| 5| 5| 6| 6| 5| 5| 6| 5| 5|
DAY ON TEST | 4| 5| 8| 4| 0| 8| 4| 6| 0| 0| 8| 1| 9| 2| 4| 5| 6| 1| 1| 0| 5| 5| 2| 4| 8|
| 3| 6| 3| 3| 8| 3| 1| 6| 0| 8| 9| 3| 9| 9| 8| 9| 3| 8| 3| 0| 1| 9| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 9| 2| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + I + + + + + + + + + + M + M + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + M + + + M + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Hemorrhage | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Prostate | + A + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + A + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M M M M M + + M + + + + + M I + + M M + I M +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + M + + + M M + + + M M M + + + + + M + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + M + A + + + M M + + +|
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + M M + M + I M + M + + M M + + M +|
Hemorrhage | 1 |
Hyperplasia, Histiocytic | 2 |
__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + A + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 4 4 3 3 3 3 3 3 3 3 2 2 3 3 2 4 3 3 2|
__________________________________________________________________________|
Thymus | + M M + + + + + + + + + + + + + + + + + M M + M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
Ulcer | 3 3 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 3| 4| 5| 6| 5| 5| 6| 6| 6| 5| 6| 5| 6| 5| 2| 5| 5| 6| 6| 5| 5| 6| 5| 5|
DAY ON TEST | 4| 5| 8| 4| 0| 8| 4| 6| 0| 0| 8| 1| 9| 2| 4| 5| 6| 1| 1| 0| 5| 5| 2| 4| 8|
| 3| 6| 3| 3| 8| 3| 1| 6| 0| 8| 9| 3| 9| 9| 8| 9| 3| 8| 3| 0| 1| 9| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 9| 2| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Prepuce, Inflammation, Suppurative | |
Subcutaneous Tissue, Congestion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | |
Sternum, Developmental Malformation | X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 1 2 1 2 2 2 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + A + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Mucopurulent | X |
Hemorrhage | 2 |
Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2|
Infarct | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Respiratory Epithelium, Degeneration | |
__________________________________________________________________________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Infiltration Cellular, Mononuclear | |
Cell | 2 |
Nephropathy | 1 1 1 1 1 1 1 1 1|
Renal Tubule, Dilatation | 2 1 1 1 1 1 1 1 1 1 1 2 2 2 1 1 2 1 2|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
_____________________________________________________________________________________________________________________
| 6| 3| 4| 5| 6| 5| 5| 6| 6| 6| 5| 6| 5| 6| 5| 2| 5| 5| 6| 6| 5| 5| 6| 5| 5|
DAY ON TEST | 4| 5| 8| 4| 0| 8| 4| 6| 0| 0| 8| 1| 9| 2| 4| 5| 6| 1| 1| 0| 5| 5| 2| 4| 8|
| 3| 6| 3| 3| 8| 3| 1| 6| 0| 8| 9| 3| 9| 9| 8| 9| 3| 8| 3| 0| 1| 9| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 9| 2| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Karyomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + A + A + + + + A + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6| | |
DAY ON TEST | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3| | |
| 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + M M + M + + + + + A + + A M + + | 27 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + A + + + + + + + + + A + + | 39 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + A + + + + + + + + + A + + | 40 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + A + + + + + + + + + A + + | 39 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + A + A + + + + + + + + A A + + | 36 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + A + A + + + + + A + + A A + + | 34 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + A + A + + + + + + + + A A + + | 36 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | 2 4 3 2 4 3 2 2 2 | 13 2.6|
Basophilic Focus | X | 3 |
Eosinophilic Focus | X X X X X | 7 |
Hemorrhage | 4 | 1 4.0|
Infarct | 2 4 3 | 4 3.3|
Infiltration Cellular, Mixed Cell | 2 | 3 2.0|
Necrosis, Coagulative, Multifocal | 2 3 2 1 | 11 2.4|
Centrilobular, Necrosis | 3 | 1 3.0|
Hepatocyte, Regeneration | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 7 |
Angiectasis | 3 | 1 3.0|
Fat, Hemorrhage | | 2 1.5|
Fat, Necrosis | 2 | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + M + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Mononuclear | | |
Cell | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Ulcer | 3 | 1 3.0|
Epithelium, Hyperplasia | 2 | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + | 45 |
Foreign Body | 3 | 1 3.0|
Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Tooth | + + + + | 7 |
Dysplasia | 3 | 3 2.7|
Inflammation, Suppurative | 2 3 2 | 4 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6| | |
DAY ON TEST | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3| | |
| 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Fibrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Capsule, Hyperplasia | 1 1 1 1 2 2 2 2 | 20 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + | 45 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + M M + M + + + M + + + + + + | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Granuloma Sperm | 3 | 1 3.0|
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Mononuclear | | |
Cell | 2 1 | 3 1.7|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + A + A + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + A + A + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + A + + + + + + + + + + + + | 47 |
Hyperplasia, Neutrophil | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M I M + + A + + + + M + M + M + + M | 26 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + M M + + + M + + + + + M + + + + + + | 34 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M A M + + + + + + + + + + + | 40 |
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M + M + M + + + + M + + + + + M M I M + + M | 29 |
Hemorrhage | 2 | 2 1.5|
Hyperplasia, Histiocytic | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6| | |
DAY ON TEST | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3| | |
| 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Hematopoietic Cell Proliferation | 3 2 3 3 3 4 3 1 3 3 3 4 3 2 3 3 4 3 4 3 3 | 42 3.0|
__________________________________________________________________________|____________|
Thymus | M + M + + + M + + + A + + + + M + + + + + + + | 37 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Chronic | 2 2 | 3 2.3|
Inflammation, Suppurative | 3 | 1 3.0|
Ulcer | 3 3 2 | 5 2.8|
Prepuce, Inflammation, Suppurative | 3 | 1 3.0|
Subcutaneous Tissue, Congestion | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Fracture | X | 1 |
Sternum, Developmental Malformation | X | 2 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Mineralization | 1 1 1 2 1 1 2 1 1 1 2 | 24 1.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + A + + + + + + + + + + + + | 46 |
Exudate, Mucopurulent | | 1 |
Hemorrhage | | 1 2.0|
Metaplasia, Squamous | 1 | 2 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Congestion | | 1 2.0|
Hemorrhage | | 1 2.0|
Infarct | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + A + + + + + + + + + + + + | 47 |
Inflammation, Suppurative | 1 | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05132-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:26:30
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6| | |
DAY ON TEST | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3| | |
| 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Degeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + A + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 6 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cyst | | 1 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 2.0|
Nephropathy | 1 1 1 1 1 1 2 | 16 1.1|
Renal Tubule, Dilatation | 1 2 1 1 1 2 1 2 2 2 1 2 2 1 1 1 1 | 36 1.4|
Renal Tubule, Karyomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 28 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A + A + + + + + + + + + + + + | 42 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
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---------- END OF REPORT ----------
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