TDMS Study 05132-05 Pathology Tables
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:05
Facility: Battelle Northwest
Chemical CAS #: 116-14-3
Lock Date: 08/25/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 21 33 31 25
Natural Death 1 1 4 6
Accidently Killed 1
Survivors
Terminal Sacrifice 28 15 15 18
Moribund Sacrifice 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (60) (60) (59) (60)
Cyst 1 (2%)
Parasite Metazoan 4 (7%) 5 (8%) 3 (5%) 3 (5%)
Intestine Large, Rectum (60) (60) (59) (60)
Diverticulum 1 (2%)
Parasite Metazoan 5 (8%) 2 (3%) 2 (3%) 6 (10%)
Intestine Large, Cecum (60) (60) (59) (60)
Diverticulum 1 (2%)
Fibrosis 1 (2%)
Infiltration Cellular, Eosinophil 1 (2%)
Parasite Metazoan 1 (2%) 1 (2%) 4 (7%)
Intestine Small, Duodenum (59) (60) (59) (60)
Necrosis 1 (2%)
Liver (60) (60) (60) (60)
Angiectasis 10 (17%) 9 (15%) 14 (23%)
Basophilic Focus 50 (83%) 47 (78%) 51 (85%) 47 (78%)
Clear Cell Focus 10 (17%) 5 (8%) 15 (25%) 12 (20%)
Degeneration, Cystic 1 (2%) 4 (7%) 1 (2%) 3 (5%)
Embolus Bacterial 1 (2%)
Eosinophilic Focus 1 (2%) 9 (15%) 7 (12%) 4 (7%)
Fatty Change 15 (25%) 20 (33%) 17 (28%) 10 (17%)
Hepatodiaphragmatic Nodule 3 (5%) 7 (12%) 10 (17%) 6 (10%)
Mitotic Alteration 1 (2%)
Mixed Cell Focus 12 (20%) 15 (25%) 22 (37%) 22 (37%)
Necrosis, Focal 1 (2%) 2 (3%)
Regeneration 1 (2%) 2 (3%) 3 (5%) 8 (13%)
Bile Duct, Hyperplasia 10 (17%) 18 (30%) 12 (20%) 18 (30%)
Centrilobular, Necrosis 2 (3%) 2 (3%)
Mesentery (8) (6) (7) (7)
Polyarteritis 1 (13%) 1 (14%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Necrosis 6 (75%) 6 (100%) 7 (100%) 5 (71%)
Pancreas (60) (60) (59) (60)
Basophilic Focus 3 (5%) 1 (2%) 2 (3%) 1 (2%)
Hyperplasia 1 (2%)
Metaplasia 1 (2%)
Metaplasia, Hepatocyte 2 (3%)
Acinus, Atrophy 18 (30%) 15 (25%) 11 (19%) 12 (20%)
Pharynx (1)
Palate, Hyperplasia 1 (100%)
Stomach, Forestomach (60) (60) (58) (60)
Acanthosis 4 (7%) 4 (7%) 2 (3%) 1 (2%)
Diverticulum 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
Necrosis 5 (8%) 4 (7%)
Ulcer 1 (2%)
Stomach, Glandular (60) (60) (59) (60)
Mineralization 1 (2%) 1 (2%) 2 (3%)
Necrosis 2 (3%) 1 (2%) 2 (3%) 1 (2%)
Tongue (2) (2) (1)
Hyperplasia, Squamous 1 (50%)
Epithelium, Hyperplasia 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Cardiomyopathy 49 (82%) 50 (83%) 49 (82%) 43 (72%)
Embolus Bacterial 1 (2%)
Polyarteritis 1 (2%)
Atrium, Thrombosis 1 (2%) 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Embolus Bacterial 1 (2%)
Fibrosis 1 (2%)
Hyperplasia 19 (32%) 12 (20%) 17 (28%) 24 (40%)
Hypertrophy 6 (10%) 4 (7%) 3 (5%) 5 (8%)
Metaplasia, Osseous 1 (2%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 5 (8%) 3 (5%) 4 (7%) 3 (5%)
Adrenal Medulla (60) (60) (60) (60)
Embolus Bacterial 1 (2%)
Hyperplasia 6 (10%) 9 (15%) 3 (5%) 8 (13%)
Islets, Pancreatic (60) (60) (59) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (2%)
Parathyroid Gland (58) (59) (59) (57)
Hyperplasia 1 (2%)
Pituitary Gland (60) (60) (59) (60)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 10 (17%) 13 (22%) 16 (27%) 20 (33%)
Thyroid Gland (60) (60) (60) (60)
C-Cell, Hyperplasia 57 (95%) 47 (78%) 50 (83%) 47 (78%)
Follicular Cell, Hyperplasia 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (59) (59) (60) (58)
Dilatation 1 (2%)
Hyperplasia 1 (2%) 1 (2%) 1 (2%) 2 (3%)
Inflammation, Chronic Active 3 (5%) 4 (7%) 8 (13%) 2 (3%)
Duct, Ectasia 1 (2%)
Ovary (60) (60) (60) (60)
Cyst 4 (7%) 4 (7%) 3 (5%) 2 (3%)
Uterus (60) (60) (60) (60)
Cyst 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Hyperplasia, Reticulum Cell 2 (3%) 2 (3%) 3 (5%) 3 (5%)
Myelofibrosis 3 (5%) 1 (2%)
Lymph Node (3) (8) (7) (13)
Lumbar, Pigmentation 1 (13%)
Renal, Hemorrhage 1 (33%) 1 (13%) 1 (14%) 2 (15%)
Lymph Node, Bronchial (59) (58) (59) (54)
Hemorrhage 2 (3%)
Lymph Node, Mandibular (58) (58) (60) (60)
Hemorrhage 1 (2%) 2 (3%)
Infiltration Cellular, Plasma Cell 3 (5%) 2 (3%)
Lymph Node, Mesenteric (60) (60) (60) (60)
Embolus Bacterial 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Lymph Node, Mediastinal (57) (59) (59) (54)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage 4 (7%) 5 (8%) 3 (5%) 2 (4%)
Spleen (60) (60) (59) (60)
Angiectasis 1 (2%) 1 (2%)
Developmental Malformation 1 (2%)
Fibrosis 1 (2%) 1 (2%) 1 (2%) 2 (3%)
Hematopoietic Cell Proliferation 1 (2%)
Infiltration Cellular, Lipocyte 2 (3%)
Thymus (57) (58) (59) (58)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (60) (60) (60)
Cyst 1 (2%)
Hyperplasia, Focal 1 (2%)
Skin (60) (60) (60) (60)
Inflammation, Chronic Active 2 (3%) 4 (7%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Hyperostosis 6 (10%) 14 (23%) 8 (13%) 3 (5%)
Tibia, Fracture 1 (2%)
Turbinate, Fracture 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 30 (50%) 23 (38%) 20 (33%) 19 (32%)
Embolus Bacterial 1 (2%)
Hemorrhage 2 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (60) (60) (60) (60)
Inflammation, Chronic Active 15 (25%) 17 (28%) 19 (32%) 24 (40%)
Metaplasia, Squamous 2 (3%) 3 (5%) 3 (5%) 5 (8%)
Mineralization 38 (63%) 35 (58%) 41 (68%) 40 (67%)
Lung (60) (60) (60) (60)
Hemorrhage 27 (45%) 18 (30%) 22 (37%) 15 (25%)
Infiltration Cellular, Lymphocyte 1 (2%)
Infiltration Cellular, Histiocyte 3 (5%) 1 (2%) 3 (5%) 3 (5%)
Inflammation, Chronic Active 2 (3%) 3 (5%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 9 (15%) 5 (8%) 11 (18%) 6 (10%)
Mediastinum, Polyarteritis 1 (2%)
Nose (60) (60) (60) (60)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (3%) 3 (5%) 5 (8%)
Thrombosis 1 (2%)
Nares, Inflammation, Chronic Active 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (51) (50) (50) (50)
Cataract 16 (31%) 4 (8%) 10 (20%) 45 (90%)
Degeneration 2 (4%) 1 (2%) 3 (6%) 2 (4%)
Hemorrhage 3 (6%) 3 (6%) 2 (4%) 3 (6%)
Cornea, Inflammation, Chronic Active 1 (2%) 2 (4%)
Cornea, Mineralization 1 (2%) 2 (4%) 2 (4%) 3 (6%)
Retina, Atrophy 22 (43%) 11 (22%) 15 (30%) 21 (42%)
Retina, Degeneration 33 (65%) 23 (46%) 14 (28%) 13 (26%)
Harderian Gland (1) (1)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Embolus Bacterial 1 (2%)
Hyperplasia, Atypical 1 (2%)
Nephropathy 56 (93%) 55 (92%) 57 (95%) 57 (95%)
Papilla, Necrosis 1 (2%)
Pelvis, Dilatation 1 (2%) 1 (2%)
Renal Tubule, Degeneration 45 (75%) 56 (93%)
Renal Tubule, Hyperplasia 1 (2%) 3 (5%) 7 (12%) 12 (20%)
Renal Tubule, Hyperplasia, Oncocytic 4 (7%)
Urinary Bladder (59) (60) (60) (59)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 156 PPM 312 PPM 625 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Natural Death 6 4 1 1
Moribund Sacrifice 27 34 32 48
Survivors
Terminal Sacrifice 17 12 17 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (60) (60) (60) (60)
Mineralization 1 (2%) 2 (3%) 1 (2%)
Parasite Metazoan 2 (3%) 1 (2%) 3 (5%)
Intestine Large, Rectum (59) (60) (60) (60)
Parasite Metazoan 3 (5%) 1 (2%) 2 (3%)
Intestine Large, Cecum (60) (60) (60) (60)
Fibrosis 1 (2%)
Inflammation, Suppurative 1 (2%)
Parasite Metazoan 2 (3%) 1 (2%)
Intestine Small, Duodenum (60) (60) (60) (60)
Necrosis 1 (2%)
Intestine Small, Ileum (59) (59) (60) (60)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 1 (2%)
Peyer's Patch, Inflammation, Granulomatous 1 (2%)
Liver (60) (60) (60) (60)
Angiectasis 3 (5%) 2 (3%) 3 (5%)
Basophilic Focus 28 (47%) 23 (38%) 40 (67%) 33 (55%)
Clear Cell Focus 11 (18%) 18 (30%) 20 (33%) 13 (22%)
Congestion 1 (2%)
Cyst 1 (2%)
Degeneration, Cystic 17 (28%) 40 (67%) 38 (63%) 32 (53%)
Eosinophilic Focus 4 (7%) 18 (30%) 22 (37%) 20 (33%)
Fatty Change 5 (8%) 3 (5%) 4 (7%) 5 (8%)
Fibrosis 1 (2%)
Hepatodiaphragmatic Nodule 3 (5%) 2 (3%) 4 (7%) 5 (8%)
Hyperplasia 1 (2%)
Mineralization 1 (2%)
Mixed Cell Focus 5 (8%) 7 (12%) 18 (30%) 15 (25%)
Necrosis, Focal 1 (2%)
Regeneration 3 (5%) 4 (7%) 1 (2%) 1 (2%)
Thrombosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 156 PPM 312 PPM 625 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Duct, Hyperplasia 51 (85%) 52 (87%) 50 (83%) 45 (75%)
Centrilobular, Necrosis 3 (5%) 1 (2%) 1 (2%)
Serosa, Fibrosis 1 (2%)
Mesentery (17) (11) (20) (18)
Inflammation, Suppurative 2 (12%)
Fat, Hemorrhage 2 (12%) 3 (15%) 1 (6%)
Fat, Necrosis 12 (71%) 11 (100%) 18 (90%) 15 (83%)
Pancreas (60) (60) (60) (60)
Basophilic Focus 4 (7%) 3 (5%) 4 (7%)
Hyperplasia 3 (5%) 1 (2%) 4 (7%)
Acinus, Atrophy 36 (60%) 32 (53%) 33 (55%) 24 (40%)
Duct, Concretion 1 (2%)
Stomach, Forestomach (60) (60) (60) (60)
Acanthosis 2 (3%) 1 (2%) 2 (3%) 5 (8%)
Diverticulum 2 (3%) 1 (2%) 2 (3%)
Infiltration Cellular, Mast Cell 1 (2%) 1 (2%)
Mineralization 1 (2%) 2 (3%) 3 (5%)
Necrosis 6 (10%) 4 (7%) 1 (2%) 6 (10%)
Stomach, Glandular (60) (60) (60) (60)
Mineralization 2 (3%) 3 (5%) 4 (7%) 13 (22%)
Necrosis 5 (8%) 3 (5%) 3 (5%)
Tongue (1) (1) (1)
Epithelium, Hyperplasia 1 (100%)
Tooth (2) (2) (1) (2)
Dysplasia 2 (100%) 2 (100%) 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (3) (12)
Mineralization 1 (100%) 2 (67%) 3 (25%)
Aorta, Mineralization 1 (100%) 3 (100%) 12 (100%)
Heart (60) (60) (60) (60)
Cardiomyopathy 56 (93%) 54 (90%) 53 (88%) 58 (97%)
Mineralization 1 (2%) 2 (3%) 4 (7%)
Atrium, Thrombosis 2 (3%) 3 (5%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Hyperplasia 17 (28%) 15 (25%) 22 (37%) 19 (32%)
Hypertrophy 4 (7%) 4 (7%) 5 (8%) 4 (7%)
Vacuolization Cytoplasmic 2 (3%)
Adrenal Medulla (60) (60) (60) (60)
Hyperplasia 24 (40%) 21 (35%) 23 (38%) 27 (45%)
Islets, Pancreatic (60) (60) (60) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 156 PPM 312 PPM 625 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (60) (60) (60) (59)
Hyperplasia 1 (2%) 3 (5%) 7 (12%) 25 (42%)
Pituitary Gland (60) (58) (59) (59)
Thrombosis 1 (2%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Hyperplasia 10 (17%) 6 (10%) 8 (14%) 15 (25%)
Thyroid Gland (60) (60) (60) (60)
C-Cell, Hyperplasia 26 (43%) 30 (50%) 40 (67%) 26 (43%)
Follicular Cell, Hyperplasia 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (60) (60) (60)
Granuloma Sperm 1 (2%)
Thrombosis 1 (2%)
Preputial Gland (60) (60) (60) (59)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic Active 13 (22%) 16 (27%) 17 (28%) 20 (34%)
Inflammation, Granulomatous 1 (2%)
Duct, Ectasia 1 (2%) 1 (2%)
Prostate (60) (60) (60) (60)
Inflammation, Chronic Active 2 (3%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Seminal Vesicle (60) (60) (60) (60)
Inflammation, Suppurative 1 (2%)
Mineralization 2 (3%) 1 (2%)
Testes (60) (60) (60) (60)
Atrophy 2 (3%) 3 (5%) 2 (3%)
Interstitial Cell, Hyperplasia 10 (17%) 14 (23%) 6 (10%) 9 (15%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Hyperplasia, Reticulum Cell 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Lymph Node (11) (17) (16) (17)
Iliac, Pigmentation 1 (6%)
Lumbar, Hemorrhage 2 (12%)
Pancreatic, Edema 1 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 156 PPM 312 PPM 625 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Renal, Edema 2 (12%)
Renal, Hemorrhage 1 (6%)
Renal, Pigmentation 1 (6%)
Lymph Node, Bronchial (55) (60) (56) (57)
Hemorrhage 1 (2%)
Lymph Node, Mandibular (60) (57) (59) (56)
Hemorrhage 1 (2%) 2 (4%)
Infiltration Cellular, Plasma Cell 2 (3%) 5 (8%) 2 (4%)
Lymph Node, Mesenteric (60) (60) (60) (60)
Edema 1 (2%)
Hemorrhage 1 (2%) 2 (3%)
Inflammation, Chronic Active 1 (2%)
Lymph Node, Mediastinal (59) (57) (58) (56)
Hemorrhage 5 (8%) 2 (4%) 2 (3%) 4 (7%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Spleen (60) (60) (60) (60)
Congestion 1 (2%)
Developmental Malformation 4 (7%) 3 (5%) 2 (3%) 4 (7%)
Fibrosis 9 (15%) 14 (23%) 11 (18%) 6 (10%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 2 (3%)
Infiltration Cellular, Lipocyte 1 (2%)
Capsule, Fibrosis 1 (2%) 2 (3%)
Thymus (56) (57) (57) (54)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (38) (43) (45) (39)
Galactocele 1 (3%) 1 (2%) 1 (3%)
Inflammation, Chronic Active 1 (3%) 1 (2%)
Skin (59) (60) (60) (60)
Acanthosis 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Hyperkeratosis 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 9 (15%) 5 (8%) 5 (8%) 4 (7%)
Necrosis 1 (2%)
Prepuce, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Hyperostosis 1 (2%) 1 (2%) 1 (2%)
Cranium, Fibrous Osteodystrophy 1 (2%) 1 (2%) 3 (5%) 17 (28%)
Femur, Fibrous Osteodystrophy 1 (2%) 1 (2%) 3 (5%) 19 (32%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 156 PPM 312 PPM 625 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Sternum, Developmental Malformation 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 12 (20%) 11 (18%) 9 (15%) 6 (10%)
Hemorrhage 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (60) (60) (60) (60)
Inflammation, Chronic Active 14 (23%) 14 (23%) 13 (22%) 19 (32%)
Metaplasia, Squamous 1 (2%) 1 (2%) 2 (3%)
Mineralization 42 (70%) 46 (77%) 44 (73%) 42 (70%)
Lung (60) (60) (60) (60)
Congestion 1 (2%)
Hemorrhage 19 (32%) 15 (25%) 13 (22%) 18 (30%)
Inflammation, Chronic Active 1 (2%)
Metaplasia, Osseous 1 (2%)
Mineralization 1 (2%) 1 (2%) 3 (5%) 12 (20%)
Thrombosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 6 (10%) 6 (10%) 6 (10%) 3 (5%)
Nose (60) (60) (60) (60)
Inflammation, Suppurative 5 (8%) 3 (5%) 4 (7%) 7 (12%)
Thrombosis 2 (3%) 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (2%)
Olfactory Epithelium, Degeneration 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 2 (3%)
Trachea (60) (60) (60) (60)
Metaplasia, Squamous 1 (2%) 1 (2%)
Mineralization 1 (2%) 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (45) (42) (48) (42)
Cataract 3 (7%) 4 (8%)
Degeneration 1 (2%) 4 (8%)
Cornea, Inflammation, Chronic Active 1 (2%) 4 (10%)
Cornea, Mineralization 1 (2%) 2 (4%) 7 (17%)
Retina, Atrophy 3 (7%) 2 (5%) 5 (10%) 2 (5%)
Harderian Gland (1)
Hypertrophy 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 156 PPM 312 PPM 625 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Cyst 1 (2%)
Developmental Malformation 1 (2%)
Infarct 3 (5%)
Mineralization 1 (2%) 3 (5%) 4 (7%)
Nephropathy 59 (98%) 60 (100%) 60 (100%) 60 (100%)
Pelvis, Dilatation 1 (2%)
Renal Tubule, Degeneration 3 (5%) 28 (47%) 60 (100%) 59 (98%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%) 2 (3%) 7 (12%)
Renal Tubule, Hyperplasia, Oncocytic 1 (2%)
Urinary Bladder (59) (60) (60) (60)
Hemorrhage 1 (2%)
Inflammation, Suppurative 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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