TDMS Study 05132-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest TETRAFLUOROETHYLENE DATE: 04/04/96
EXPERIMENT: 05132 TEST: 05 TIME: 00:41:35
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES85207 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61596B
PATHOLOGIST: S. GRUMBEIN CAS: 116-14-3
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest TETRAFLUOROETHYLENE DATE: 04/04/96
EXPERIMENT: 05132 TEST: 05 TIME: 00:41:35
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES85207 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61596B
PATHOLOGIST: S. GRUMBEIN CAS: 116-14-3
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest TETRAFLUOROETHYLENE DATE: 04/04/96
EXPERIMENT: 05132 TEST: 05 TIME: 00:41:35
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES85207 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61596B
PATHOLOGIST: S. GRUMBEIN CAS: 116-14-3
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF TETRAFLUOROETHYLENE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Islets, Pancreatic Carcinoma
Kidney: Renal Tubule Adenoma
Carcinoma or Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Skin Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal
Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma
Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma
Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma
Testes Adenoma
Urinary Bladder Papilloma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest TETRAFLUOROETHYLENE DATE: 04/04/96
EXPERIMENT: 05132 TEST: 05 TIME: 00:41:35
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES85207 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61596B
PATHOLOGIST: S. GRUMBEIN CAS: 116-14-3
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF TETRAFLUOROETHYLENE
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Kidney: Renal Tubule Adenoma
Carcinoma
Carcinoma or Adenoma
Liver Hemangiosarcoma
Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
All Organs Hemangiosarcoma
Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 8.2% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 674 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.372 (e) P=0.189 (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.514 (e) P=0.157 (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.508 (e) P=0.230 (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.596 | (e) |
|FISHER EXACT | (e) P=0.248 (e) | (e) (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/60 (32%) 11/60 (18%) 9/60 (15%) 10/60 (17%) | 4/60 (7%) 1/60 (2%) 2/60 (3%) 5/60 (8%) |
|ADJUSTED (b) | 60.0% 44.2% 33.4% 52.8% | 12.7% 3.2% 9.6% 20.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/17 (35%) 2/12 (17%) 4/17 (24%) 0/1 (0%) | 2/28 (7%) 0/16 (0%) 1/15 (7%) 2/18 (11%) |
|FIRST INCIDENCE (DAYS) | 588 594 576 481 | 698 618 653 610 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.282 P=0.280N P=0.058N P=0.083 | P=0.136 P=0.347N P=0.577N P=0.239 |
|INCIDENTAL TUMOR | P=0.093N P=0.093N P=0.022N* P=0.176N | P=0.223 P=0.200N P=0.437N P=0.491 |
|LOGISTIC REGRESSION | P=0.062N P=0.090N P=0.027N* P=0.280N | P=0.171 P=0.267N P=0.472N P=0.317 |
|COCHRAN-ARMITAGE | P=0.044N* | P=0.274 |
|FISHER EXACT | P=0.070N P=0.025N* P=0.043N* | P=0.182N P=0.340N P=0.500 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 10.4% 0.0% 3.6% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/17 (6%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 715 --- 664 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.402N P=0.310N P=0.528N P=0.786N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.309N P=0.291N P=0.588N P=0.528N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.298N P=0.300N P=0.526N P=0.636N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.189N | (e) |
|FISHER EXACT | P=0.248N P=0.500N P=0.248N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/60 (33%) 12/60 (20%) 9/60 (15%) 10/60 (17%) | 4/60 (7%) 1/60 (2%) 2/60 (3%) 5/60 (8%) |
|ADJUSTED (b) | 63.6% 49.8% 33.4% 52.8% | 12.7% 3.2% 9.6% 20.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 7/17 (41%) 3/12 (25%) 4/17 (24%) 0/1 (0%) | 2/28 (7%) 0/16 (0%) 1/15 (7%) 2/18 (11%) |
|FIRST INCIDENCE (DAYS) | 588 594 576 481 | 698 618 653 610 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.331 P=0.305N P=0.039N* P=0.087 | P=0.136 P=0.347N P=0.577N P=0.239 |
|INCIDENTAL TUMOR | P=0.074N P=0.111N P=0.014N* P=0.169N | P=0.223 P=0.200N P=0.437N P=0.491 |
|LOGISTIC REGRESSION | P=0.048N* P=0.141N P=0.017N* P=0.238N | P=0.171 P=0.267N P=0.472N P=0.317 |
|COCHRAN-ARMITAGE | P=0.026N* | P=0.274 |
|FISHER EXACT | P=0.074N P=0.016N* P=0.028N* | P=0.182N P=0.340N P=0.500 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 3/60 (5%) 5/60 (8%) 2/59 (3%) | 6/59 (10%) 7/59 (12%) 2/60 (3%) 0/58 (0%) |
|ADJUSTED (b) | 5.9% 25.0% 15.6% 6.0% | 18.7% 32.6% 11.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/17 (6%) 3/12 (25%) 1/17 (6%) 0/1 (0%) | 4/28 (14%) 4/16 (25%) 1/15 (7%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 733 (T) 538 523 | 648 454 (I) 733 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.099 P=0.182 P=0.104 P=0.228 | P=0.025N* P=0.183 P=0.365N P=0.062N |
|INCIDENTAL TUMOR | P=0.314 P=0.182 P=0.112 P=0.480 | P=0.017N* P=0.260 P=0.239N P=0.071N |
|LOGISTIC REGRESSION | P=0.324 P=0.182 P=0.104 P=0.462 | P=0.014N* P=0.322 P=0.247N P=0.048N* |
|COCHRAN-ARMITAGE | P=0.430 | P=0.005N** |
|FISHER EXACT | P=0.309 P=0.103 P=0.494 | P=0.500 P=0.131N P=0.014N* |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 3/60 (5%) 2/60 (3%) 4/59 (7%) | 1/59 (2%) 2/59 (3%) 2/60 (3%) 2/58 (3%) |
|ADJUSTED (b) | 17.1% 10.0% 4.9% 13.9% | 3.6% 7.9% 8.3% 8.6% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/17 (12%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 1/28 (4%) 1/16 (6%) 0/15 (0%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | 453 (I) 494 538 481 | 734 (T) 454 (I) 625 610 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.271 P=0.603N P=0.353N P=0.190 | P=0.308 P=0.372 P=0.350 P=0.356 |
|INCIDENTAL TUMOR | P=0.443N P=0.506N P=0.367N P=0.639 | P=0.387 P=0.372 P=0.537 P=0.523 |
|LOGISTIC REGRESSION | P=0.559 P=0.508N P=0.338N P=0.608 | P=0.360 P=0.490 P=0.434 P=0.394 |
|COCHRAN-ARMITAGE | P=0.548 | P=0.417 |
|FISHER EXACT | P=0.500N P=0.340N P=0.632 | P=0.500 P=0.506 P=0.494 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 6/60 (10%) 6/60 (10%) 6/59 (10%) | 7/59 (12%) 9/59 (15%) 4/60 (7%) 2/58 (3%) |
|ADJUSTED (b) | 22.6% 32.5% 18.1% 19.0% | 22.1% 39.3% 19.5% 8.6% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 2/10 (20%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/17 (18%) 3/12 (25%) 1/17 (6%) 0/1 (0%) | 5/28 (18%) 5/16 (31%) 1/15 (7%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | 453 (I) 494 538 481 | 648 454 (I) 625 610 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.072 P=0.330 P=0.476 P=0.067 | P=0.115N P=0.104 P=0.594N P=0.243N |
|INCIDENTAL TUMOR | P=0.473 P=0.407 P=0.537 P=0.463 | P=0.074N P=0.153 P=0.369N P=0.186N |
|LOGISTIC REGRESSION | P=0.379 P=0.440 P=0.498 P=0.444 | P=0.069N P=0.243 P=0.427N P=0.196N |
|COCHRAN-ARMITAGE | P=0.443 | P=0.030N* |
|FISHER EXACT | P=0.500 P=0.500 P=0.488 | P=0.394 P=0.255N P=0.085N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) 1/60 (2%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 1/59 (2%) 0/60 (0%) |
|ADJUSTED (b) | 15.3% 5.6% 5.9% 20.5% | 0.0% 0.0% 6.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/17 (12%) 0/12 (0%) 1/17 (6%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 1/15 (7%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 705 705 733 (T) 626 | --- --- 734 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.248 P=0.433N P=0.324N P=0.182 | P=0.635 (e) P=0.376 (e) |
|INCIDENTAL TUMOR | P=0.513 P=0.390N P=0.338N P=0.579 | P=0.635 (e) P=0.376 (e) |
|LOGISTIC REGRESSION | P=0.455 P=0.401N P=0.339N P=0.507 | P=0.635 (e) P=0.376 (e) |
|COCHRAN-ARMITAGE | P=0.475N | P=0.694 |
|FISHER EXACT | P=0.309N P=0.309N P=0.500N | (e) P=0.496 (e) |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 5/60 (8%) 1/60 (2%) 1/60 (2%) | 0/60 (0%) 1/60 (2%) 0/59 (0%) 0/60 (0%) |
|ADJUSTED (b) | 3.4% 31.5% 5.9% 3.0% | 0.0% 3.8% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 3/12 (25%) 1/17 (6%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 690 664 733 (T) 593 | --- 653 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.432 P=0.049 * P=0.730 P=0.587 | P=0.632N P=0.409 (e) (e) |
|INCIDENTAL TUMOR | P=0.595N P=0.058 P=0.719 P=0.700N | P=0.680N P=0.438 (e) (e) |
|LOGISTIC REGRESSION | P=0.566N P=0.058 P=0.743 P=0.730 | P=0.586N P=0.486 (e) (e) |
|COCHRAN-ARMITAGE | P=0.313N | P=0.567N |
|FISHER EXACT | P=0.103 P=0.752N P=0.752N | P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 6/60 (10%) 2/60 (3%) 3/60 (5%) | 0/60 (0%) 1/60 (2%) 1/59 (2%) 0/60 (0%) |
|ADJUSTED (b) | 18.2% 35.3% 11.8% 22.9% | 0.0% 3.8% 6.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/17 (12%) 3/12 (25%) 2/17 (12%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 1/15 (7%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 690 664 733 (T) 593 | --- 653 734 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.202 P=0.192 P=0.375N P=0.144 | P=0.674N P=0.409 P=0.376 (e) |
|INCIDENTAL TUMOR | P=0.524 P=0.232 P=0.395N P=0.621 | P=0.682 P=0.438 P=0.376 (e) |
|LOGISTIC REGRESSION | P=0.508 P=0.227 P=0.387N P=0.510 | P=0.654N P=0.486 P=0.376 (e) |
|COCHRAN-ARMITAGE | P=0.279N | P=0.595N |
|FISHER EXACT | P=0.372 P=0.340N P=0.500N | P=0.500 P=0.496 (e) |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 6/60 (10%) 3/60 (5%) | 0/60 (0%) 3/60 (5%) 1/60 (2%) 4/60 (7%) |
|ADJUSTED (b) | 0.0% 0.0% 25.7% 18.4% | 0.0% 13.7% 3.3% 18.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 0/17 (0%) 0/12 (0%) 3/17 (18%) 0/1 (0%) | 0/28 (0%) 1/16 (6%) 0/15 (0%) 3/18 (17%) |
|FIRST INCIDENCE (DAYS) | --- --- 627 617 | --- 574 668 454 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** (e) P=0.015 * P=0.032 * | P=0.039 * P=0.066 P=0.443 P=0.029 * |
|INCIDENTAL TUMOR | P=0.017 * (e) P=0.016 * P=0.223 | P=0.038 * P=0.126 P=0.536 P=0.029 * |
|LOGISTIC REGRESSION | P=0.011 * (e) P=0.015 * P=0.076 | P=0.046 * P=0.088 P=0.481 P=0.041 * |
|COCHRAN-ARMITAGE | P=0.048 * | P=0.072 |
|FISHER EXACT | (e) P=0.014 * P=0.122 | P=0.122 P=0.500 P=0.059 |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 2/60 (3%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | 2.8% 0.0% 9.2% 1.7% | 0.0% 0.0% 0.0% 11.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 0/12 (0%) 1/17 (6%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 0/15 (0%) 2/18 (11%) |
|FIRST INCIDENCE (DAYS) | 649 --- 664 453 (I) | --- --- --- 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.264 P=0.543N P=0.457 P=0.662 | P=0.035 * (e) (e) P=0.147 |
|INCIDENTAL TUMOR | P=0.339 P=0.522N P=0.412 P=0.719 | P=0.035 * (e) (e) P=0.147 |
|LOGISTIC REGRESSION | P=0.487 P=0.509N P=0.488 P=0.731N | P=0.035 * (e) (e) P=0.147 |
|COCHRAN-ARMITAGE | P=0.500 | P=0.046 * |
|FISHER EXACT | P=0.500N P=0.500 P=0.752N | (e) (e) P=0.248 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 6/60 (10%) 4/60 (7%) | 0/60 (0%) 3/60 (5%) 1/60 (2%) 6/60 (10%) |
|ADJUSTED (b) | 2.8% 0.0% 25.7% 19.8% | 0.0% 13.7% 3.3% 29.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 0/17 (0%) 0/12 (0%) 3/17 (18%) 0/1 (0%) | 0/28 (0%) 1/16 (6%) 0/15 (0%) 5/18 (28%) |
|FIRST INCIDENCE (DAYS) | 649 --- 627 453 (I) | --- 574 668 454 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.001 ** P=0.543N P=0.049 * P=0.051 | P=0.004 ** P=0.066 P=0.443 P=0.004 ** |
|INCIDENTAL TUMOR | P=0.021 * P=0.522N P=0.047 * P=0.254 | P=0.004 ** P=0.126 P=0.536 P=0.004 ** |
|LOGISTIC REGRESSION | P=0.025 * P=0.509N P=0.052 P=0.174 | P=0.004 ** P=0.088 P=0.481 P=0.006 ** |
|COCHRAN-ARMITAGE | P=0.053 | P=0.011 * |
|FISHER EXACT | P=0.500N P=0.057 P=0.182 | P=0.122 P=0.500 P=0.014 * |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 5/60 (8%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 19.5% 5.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- 589 703 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.143 (e) P=0.013 * P=0.400 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.106 (e) P=0.059 P=0.318 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.171 (e) P=0.021 * P=0.428 |
|COCHRAN-ARMITAGE | (e) | P=0.242 |
|FISHER EXACT | (e) (e) (e) | (e) P=0.029 * P=0.500 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 6/60 (10%) 9/60 (15%) 5/60 (8%) | 0/60 (0%) 4/60 (7%) 5/60 (8%) 6/60 (10%) |
|ADJUSTED (b) | 14.1% 32.0% 44.0% 100.0% | 0.0% 22.6% 33.3% 28.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/17 (12%) 3/12 (25%) 7/17 (41%) 1/1 (100%) | 0/28 (0%) 3/16 (19%) 5/15 (33%) 3/18 (17%) |
|FIRST INCIDENCE (DAYS) | 632 600 453 (I) 572 | --- 707 734 (T) 677 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005 ** P=0.127 P=0.051 P=0.018 * | P=0.006 ** P=0.017 * P=0.003 ** P=0.003 ** |
|INCIDENTAL TUMOR | P=0.067 P=0.208 P=0.080 P=0.185 | P=0.003 ** P=0.018 * P=0.003 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.114 P=0.180 P=0.049 * P=0.184 | P=0.004 ** P=0.020 * P=0.003 ** P=0.003 ** |
|COCHRAN-ARMITAGE | P=0.342 | P=0.026 * |
|FISHER EXACT | P=0.245 P=0.063 P=0.359 | P=0.059 P=0.029 * P=0.014 * |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 10/60 (17%) 4/60 (7%) | 0/60 (0%) 4/60 (7%) 9/60 (15%) 2/60 (3%) |
|ADJUSTED (b) | 2.6% 3.4% 41.3% 20.2% | 0.0% 20.9% 48.1% 11.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 0/12 (0%) 5/17 (29%) 0/1 (0%) | 0/28 (0%) 3/16 (19%) 6/15 (40%) 2/18 (11%) |
|FIRST INCIDENCE (DAYS) | 624 652 617 453 (I) | --- 583 668 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.710 P=0.005 ** P=0.062 | P=0.146 P=0.020 * P<0.001 ** P=0.147 |
|INCIDENTAL TUMOR | P=0.031 * P=0.726N P=0.007 ** P=0.367 | P=0.143 P=0.038 * P<0.001 ** P=0.147 |
|LOGISTIC REGRESSION | P=0.026 * P=0.757 P=0.004 ** P=0.185 | P=0.127 P=0.033 * P<0.001 ** P=0.147 |
|COCHRAN-ARMITAGE | P=0.081 | P=0.310 |
|FISHER EXACT | P=0.752N P=0.004 ** P=0.182 | P=0.059 P=0.001 ** P=0.248 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 7/60 (12%) 16/60 (27%) 9/60 (15%) | 0/60 (0%) 7/60 (12%) 12/60 (20%) 8/60 (13%) |
|ADJUSTED (b) | 16.3% 34.4% 62.7% 100.0% | 0.0% 36.3% 65.4% 37.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/17 (12%) 3/12 (25%) 9/17 (53%) 1/1 (100%) | 0/28 (0%) 5/16 (31%) 9/15 (60%) 5/18 (28%) |
|FIRST INCIDENCE (DAYS) | 624 600 453 (I) 453 (I) | --- 583 668 677 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.137 P=0.003 ** P=0.002 ** | P=0.002 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.012 * P=0.246 P=0.005 ** P=0.102 | P=0.001 ** P=0.002 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.015 * P=0.202 P=0.002 ** P=0.063 | P=0.001 ** P=0.002 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.090 | P=0.021 * |
|FISHER EXACT | P=0.264 P=0.003 ** P=0.120 | P=0.006 ** P<0.001 ** P=0.003 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 7/60 (12%) 16/60 (27%) 9/60 (15%) | 0/60 (0%) 7/60 (12%) 12/60 (20%) 8/60 (13%) |
|ADJUSTED (b) | 16.3% 34.4% 62.7% 100.0% | 0.0% 36.3% 65.4% 37.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/17 (12%) 3/12 (25%) 9/17 (53%) 1/1 (100%) | 0/28 (0%) 5/16 (31%) 9/15 (60%) 5/18 (28%) |
|FIRST INCIDENCE (DAYS) | 624 600 453 (I) 453 (I) | --- 583 668 677 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.137 P=0.003 ** P=0.002 ** | P=0.002 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.012 * P=0.246 P=0.005 ** P=0.102 | P=0.001 ** P=0.002 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.015 * P=0.202 P=0.002 ** P=0.063 | P=0.001 ** P=0.002 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.090 | P=0.021 * |
|FISHER EXACT | P=0.264 P=0.003 ** P=0.120 | P=0.006 ** P<0.001 ** P=0.003 ** |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 2/60 (3%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 8.3% 8.4% 3.3% | 0.0% 0.0% 6.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 1/12 (8%) 1/17 (6%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 1/15 (7%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 621 604 | --- --- 734 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.128 P=0.431 P=0.234 P=0.448 | P=0.635 (e) P=0.376 (e) |
|INCIDENTAL TUMOR | P=0.311 P=0.431 P=0.314 P=0.718 | P=0.635 (e) P=0.376 (e) |
|LOGISTIC REGRESSION | P=0.259 P=0.431 P=0.231 P=0.502 | P=0.635 (e) P=0.376 (e) |
|COCHRAN-ARMITAGE | P=0.367 | P=0.694 |
|FISHER EXACT | P=0.500 P=0.248 P=0.500 | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 2/60 (3%) 1/60 (2%) | 0/60 (0%) 1/60 (2%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 1.7% 8.3% 8.4% 3.3% | 0.0% 6.3% 6.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 1/12 (8%) 1/17 (6%) 0/1 (0%) | 0/28 (0%) 1/16 (6%) 1/15 (7%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 453 (I) 733 (T) 621 604 | --- 734 (T) 734 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.366 P=0.722 P=0.494 P=0.732 | P=0.667N P=0.388 P=0.376 (e) |
|INCIDENTAL TUMOR | P=0.572 P=0.722 P=0.578 P=0.647N | P=0.667N P=0.388 P=0.376 (e) |
|LOGISTIC REGRESSION | P=0.572 P=0.756N P=0.498 P=0.729N | P=0.667N P=0.388 P=0.376 (e) |
|COCHRAN-ARMITAGE | P=0.591 | P=0.595N |
|FISHER EXACT | P=0.752N P=0.500 P=0.752N | P=0.500 P=0.500 (e) |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 1/60 (2%) 0/60 (0%) | 3/60 (5%) 1/60 (2%) 4/60 (7%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 4.8% 2.8% 0.0% | 8.9% 2.6% 18.6% 5.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 1/28 (4%) 0/16 (0%) 2/15 (13%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | --- 698 627 --- | 693 581 611 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.630 P=0.450 P=0.489 (e) | P=0.523N P=0.461N P=0.262 P=0.501N |
|INCIDENTAL TUMOR | P=0.527N P=0.478 P=0.638 (e) | P=0.445N P=0.291N P=0.452 P=0.563N |
|LOGISTIC REGRESSION | P=0.657N P=0.465 P=0.500 (e) | P=0.455N P=0.362N P=0.391 P=0.467N |
|COCHRAN-ARMITAGE | P=0.595N | P=0.344N |
|FISHER EXACT | P=0.500 P=0.500 (e) | P=0.309N P=0.500 P=0.309N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 1/60 (2%) 1/60 (2%) | 4/60 (7%) 1/60 (2%) 5/60 (8%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 4.8% 2.8% 2.2% | 12.2% 2.6% 22.5% 11.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 2/28 (7%) 0/16 (0%) 2/15 (13%) 2/18 (11%) |
|FIRST INCIDENCE (DAYS) | --- 698 627 523 | 693 581 611 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.232 P=0.450 P=0.489 P=0.496 | P=0.522 P=0.336N P=0.226 P=0.575N |
|INCIDENTAL TUMOR | P=0.494 P=0.478 P=0.638 P=0.638 | P=0.577N P=0.200N P=0.427 P=0.626N |
|LOGISTIC REGRESSION | P=0.381 P=0.465 P=0.500 P=0.530 | P=0.577N P=0.244N P=0.362 P=0.567N |
|COCHRAN-ARMITAGE | P=0.385 | P=0.421N |
|FISHER EXACT | P=0.500 P=0.500 P=0.500 | P=0.182N P=0.500 P=0.340N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/60 (3%) 2/60 (3%) 1/60 (2%) | 22/60 (37%) 11/60 (18%) 9/60 (15%) 8/60 (13%) |
|ADJUSTED (b) | 10.4% 12.7% 11.8% 9.1% | 55.2% 41.8% 38.1% 29.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 1/17 (6%) 1/12 (8%) 2/17 (12%) 0/1 (0%) | 11/28 (39%) 5/16 (31%) 4/15 (27%) 3/18 (17%) |
|FIRST INCIDENCE (DAYS) | 715 698 733 (T) 668 | 481 468 534 454 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.326 P=0.580 P=0.691 P=0.453 | P=0.057N P=0.277N P=0.162N P=0.086N |
|INCIDENTAL TUMOR | P=0.481 P=0.610 P=0.662 P=0.695 | P=0.008N** P=0.047N* P=0.009N** P=0.034N* |
|LOGISTIC REGRESSION | P=0.491 P=0.598 P=0.670 P=0.681 | P=0.011N* P=0.058N P=0.019N* P=0.015N* |
|COCHRAN-ARMITAGE | P=0.373N | P=0.003N** |
|FISHER EXACT | P=0.691N P=0.691N P=0.500N | P=0.020N* P=0.006N** P=0.003N** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/60 (3%) 2/60 (3%) 2/60 (3%) | 23/60 (38%) 11/60 (18%) 10/60 (17%) 9/60 (15%) |
|ADJUSTED (b) | 10.4% 12.7% 11.8% 11.1% | 57.8% 41.8% 41.1% 34.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 1/17 (6%) 1/12 (8%) 2/17 (12%) 0/1 (0%) | 12/28 (43%) 5/16 (31%) 4/15 (27%) 4/18 (22%) |
|FIRST INCIDENCE (DAYS) | 715 698 733 (T) 523 | 481 468 534 454 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.130 P=0.580 P=0.691 P=0.229 | P=0.080N P=0.232N P=0.196N P=0.103N |
|INCIDENTAL TUMOR | P=0.279 P=0.610 P=0.662 P=0.516 | P=0.014N* P=0.034N* P=0.011N* P=0.046N* |
|LOGISTIC REGRESSION | P=0.358 P=0.598 P=0.670 P=0.575 | P=0.018N* P=0.041N* P=0.023N* P=0.021N* |
|COCHRAN-ARMITAGE | P=0.596 | P=0.005N** |
|FISHER EXACT | P=0.691N P=0.691N P=0.691N | P=0.013N* P=0.007N** P=0.003N** |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/60 (3%) 3/60 (5%) 2/60 (3%) | 24/60 (40%) 12/60 (20%) 13/60 (22%) 9/60 (15%) |
|ADJUSTED (b) | 10.4% 12.7% 14.2% 11.1% | 59.0% 43.3% 49.8% 34.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 1/17 (6%) 1/12 (8%) 2/17 (12%) 0/1 (0%) | 12/28 (43%) 5/16 (31%) 5/15 (33%) 4/18 (22%) |
|FIRST INCIDENCE (DAYS) | 715 698 627 523 | 481 468 534 454 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.117 P=0.580 P=0.491 P=0.229 | P=0.079N P=0.260N P=0.386N P=0.084N |
|INCIDENTAL TUMOR | P=0.325 P=0.610 P=0.527 P=0.516 | P=0.010N* P=0.029N* P=0.034N* P=0.034N* |
|LOGISTIC REGRESSION | P=0.353 P=0.598 P=0.461 P=0.575 | P=0.015N* P=0.044N* P=0.070N P=0.014N* |
|COCHRAN-ARMITAGE | P=0.569 | P=0.003N** |
|FISHER EXACT | P=0.691N P=0.500 P=0.691N | P=0.014N* P=0.024N* P=0.002N** |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 5.9% 8.3% 0.0% 0.0% | 6.8% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/17 (6%) 1/12 (8%) 0/17 (0%) 0/1 (0%) | 1/28 (4%) 0/16 (0%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 733 (T) --- --- | 721 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.463N P=0.684 P=0.500N P=0.974N | P=0.169N P=0.350N P=0.364N P=0.343N |
|INCIDENTAL TUMOR | P=0.463N P=0.684 P=0.500N P=0.974N | P=0.163N P=0.339N P=0.284N P=0.395N |
|LOGISTIC REGRESSION | P=0.463N P=0.684 P=0.500N P=0.974N | P=0.165N P=0.338N P=0.328N P=0.353N |
|COCHRAN-ARMITAGE | P=0.236N | P=0.115N |
|FISHER EXACT | P=0.752N P=0.500N P=0.500N | P=0.248N P=0.248N P=0.248N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 9.2% 8.3% 0.0% 0.0% | 6.8% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/17 (6%) 1/12 (8%) 0/17 (0%) 0/1 (0%) | 1/28 (4%) 0/16 (0%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 691 733 (T) --- --- | 721 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.230N P=0.608N P=0.266N P=0.702N | P=0.169N P=0.350N P=0.364N P=0.343N |
|INCIDENTAL TUMOR | P=0.201N P=0.593N P=0.281N P=0.528N | P=0.163N P=0.339N P=0.284N P=0.395N |
|LOGISTIC REGRESSION | P=0.191N P=0.592N P=0.257N P=0.517N | P=0.165N P=0.338N P=0.328N P=0.353N |
|COCHRAN-ARMITAGE | P=0.101N | P=0.115N |
|FISHER EXACT | P=0.500N P=0.248N P=0.248N | P=0.248N P=0.248N P=0.248N |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 1/60 (2%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 12.7% 5.9% 5.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 1/12 (8%) 1/17 (6%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- 698 733 (T) 630 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.150 P=0.177 P=0.500 P=0.372 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.341 P=0.191 P=0.500 P=0.718 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.299 P=0.183 P=0.500 P=0.476 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.500 | (e) |
|FISHER EXACT | P=0.248 P=0.500 P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 42/60 (70%) 40/58 (69%) 36/59 (61%) 27/59 (46%) | 44/60 (73%) 36/60 (60%) 37/59 (63%) 34/60 (57%) |
|ADJUSTED (b) | 95.1% 91.5% 84.7% 87.0% | 93.5% 88.7% 94.1% 88.9% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 3/9 (33%) 1/10 (10%) 4/10 (40%) | 1/10 (10%) 2/10 (20%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 15/17 (88%) 9/12 (75%) 10/16 (63%) 0/0 | 25/28 (89%) 12/16 (75%) 13/15 (87%) 14/18 (78%) |
|FIRST INCIDENCE (DAYS) | 336 351 453 (I) 361 | 454 (I) 413 387 433 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.039 * P=0.209 P=0.410N P=0.003 ** | P=0.242 P=0.129 P=0.078 P=0.209 |
|INCIDENTAL TUMOR | P=0.011N* P=0.582N P=0.263N P=0.125N | P=0.181N P=0.213N P=0.342N P=0.204N |
|LOGISTIC REGRESSION | P=0.012N* P=0.573 P=0.179N P=0.035N* | P=0.256N P=0.323N P=0.434N P=0.198N |
|COCHRAN-ARMITAGE | P=0.002N** | P=0.061N |
|FISHER EXACT | P=0.531N P=0.201N P=0.006N** | P=0.087N P=0.148N P=0.042N* |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 42/60 (70%) 40/58 (69%) 36/59 (61%) 27/59 (46%) | 44/60 (73%) 37/60 (62%) 37/59 (63%) 34/60 (57%) |
|ADJUSTED (b) | 95.1% 91.5% 84.7% 87.0% | 93.5% 91.6% 94.1% 88.9% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 3/9 (33%) 1/10 (10%) 4/10 (40%) | 1/10 (10%) 2/10 (20%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 15/17 (88%) 9/12 (75%) 10/16 (63%) 0/0 | 25/28 (89%) 13/16 (81%) 13/15 (87%) 14/18 (78%) |
|FIRST INCIDENCE (DAYS) | 336 351 453 (I) 361 | 454 (I) 413 387 433 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.039 * P=0.209 P=0.410N P=0.003 ** | P=0.253 P=0.093 P=0.078 P=0.209 |
|INCIDENTAL TUMOR | P=0.011N* P=0.582N P=0.263N P=0.125N | P=0.164N P=0.310N P=0.342N P=0.204N |
|LOGISTIC REGRESSION | P=0.012N* P=0.573 P=0.179N P=0.035N* | P=0.304N P=0.416N P=0.434N P=0.198N |
|COCHRAN-ARMITAGE | P=0.002N** | P=0.053N |
|FISHER EXACT | P=0.531N P=0.201N P=0.006N** | P=0.121N P=0.148N P=0.042N* |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/58 (0%) 0/59 (0%) 0/59 (0%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 0/60 (0%) |
|ADJUSTED (b) | 5.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/9 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 0/12 (0%) 0/16 (0%) 0/0 | 0/28 (0%) 0/16 (0%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 453 (I) --- --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.151N P=0.281N P=0.269N P=0.362N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.135N P=0.264N P=0.281N P=0.281N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.108N P=0.238N P=0.246N P=0.214N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.117N | (e) |
|FISHER EXACT | P=0.256N P=0.252N P=0.252N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, |
| malignant or NOS), or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 10.8% 0.0% 0.0% 3.8% | 0.0% 0.0% 4.8% 5.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/17 (6%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 0/15 (0%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | 721 --- --- 617 | --- --- 702 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.658 P=0.323N P=0.234N P=0.557 | P=0.177 (e) P=0.404 P=0.412 |
|INCIDENTAL TUMOR | P=0.515N P=0.291N P=0.281N P=0.661N | P=0.151 (e) P=0.536 P=0.412 |
|LOGISTIC REGRESSION | P=0.604N P=0.303N P=0.256N P=0.755 | P=0.173 (e) P=0.454 P=0.412 |
|COCHRAN-ARMITAGE | P=0.462N | P=0.236 |
|FISHER EXACT | P=0.248N P=0.248N P=0.500N | (e) P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 7/60 (12%) 0/60 (0%) 2/60 (3%) 3/60 (5%) | 2/60 (3%) 0/60 (0%) 2/60 (3%) 3/60 (5%) |
|ADJUSTED (b) | 32.3% 0.0% 7.7% 12.6% | 7.1% 0.0% 11.1% 16.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/17 (18%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 2/28 (7%) 0/16 (0%) 1/15 (7%) 3/18 (17%) |
|FIRST INCIDENCE (DAYS) | 686 --- 575 617 | 734 (T) --- 702 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.527 P=0.029N* P=0.092N P=0.301 | P=0.136 P=0.368N P=0.470 P=0.301 |
|INCIDENTAL TUMOR | P=0.247N P=0.018N* P=0.114N P=0.331N | P=0.128 P=0.368N P=0.539 P=0.301 |
|LOGISTIC REGRESSION | P=0.407N P=0.019N* P=0.097N P=0.560N | P=0.120 P=0.368N P=0.550 P=0.301 |
|COCHRAN-ARMITAGE | P=0.212N | P=0.238 |
|FISHER EXACT | P=0.006N** P=0.081N P=0.161N | P=0.248N P=0.691N P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Basosquamous Tumor Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 10.8% 0.0% 0.0% 3.8% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/17 (6%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 721 --- --- 617 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.658 P=0.323N P=0.234N P=0.557 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.515N P=0.291N P=0.281N P=0.661N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.604N P=0.303N P=0.256N P=0.755 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.462N | (e) |
|FISHER EXACT | P=0.248N P=0.248N P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) 0/60 (0%) 1/60 (2%) | 0/60 (0%) 1/60 (2%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 11.3% 5.6% 0.0% 2.6% | 0.0% 6.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/17 (6%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 0/28 (0%) 1/16 (6%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 635 705 --- 571 | --- 734 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.430N P=0.420N P=0.150N P=0.700N | P=0.619N P=0.388 (e) (e) |
|INCIDENTAL TUMOR | P=0.184N P=0.317N P=0.102N P=0.285N | P=0.619N P=0.388 (e) (e) |
|LOGISTIC REGRESSION | P=0.256N P=0.354N P=0.126N P=0.405N | P=0.619N P=0.388 (e) (e) |
|COCHRAN-ARMITAGE | P=0.201N | P=0.567N |
|FISHER EXACT | P=0.309N P=0.122N P=0.309N | P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) 2/60 (3%) 3/60 (5%) | 1/60 (2%) 2/60 (3%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 11.3% 5.6% 5.2% 23.8% | 2.4% 8.5% 1.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/17 (6%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 0/28 (0%) 1/16 (6%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 635 705 453 (I) 525 | 663 565 387 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.171 P=0.420N P=0.556N P=0.225 | P=0.318N P=0.370 P=0.728 P=0.615N |
|INCIDENTAL TUMOR | P=0.471 P=0.317N P=0.508N P=0.671N | P=0.199N P=0.543 P=0.633N P=0.682N |
|LOGISTIC REGRESSION | P=0.446 P=0.354N P=0.500N P=0.580 | P=0.219N P=0.474 P=0.707N P=0.533N |
|COCHRAN-ARMITAGE | P=0.477 | P=0.248N |
|FISHER EXACT | P=0.309N P=0.500N P=0.660N | P=0.500 P=0.752N P=0.500N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 2/60 (3%) | 1/60 (2%) 1/60 (2%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 5.2% 21.8% | 2.4% 2.4% 1.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 453 (I) 525 | 663 565 387 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.028 * (e) P=0.218 P=0.085 | P=0.366N P=0.695 P=0.728 P=0.615N |
|INCIDENTAL TUMOR | P=0.087 (e) P=0.198 P=0.265 | P=0.217N P=0.668N P=0.633N P=0.682N |
|LOGISTIC REGRESSION | P=0.098 (e) P=0.226 P=0.224 | P=0.241N P=0.753N P=0.707N P=0.533N |
|COCHRAN-ARMITAGE | P=0.087 | P=0.312N |
|FISHER EXACT | (e) P=0.248 P=0.248 | P=0.752N P=0.752N P=0.500N |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 0/60 (0%) 1/60 (2%) 1/60 (2%) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 14.7% 0.0% 2.2% 5.3% | 7.1% 0.0% 0.0% 5.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/17 (12%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 2/28 (7%) 0/16 (0%) 0/15 (0%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | 686 --- 575 632 | 734 (T) --- --- 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.579N P=0.184N P=0.326N P=0.598 | P=0.561N P=0.368N P=0.383N P=0.653N |
|INCIDENTAL TUMOR | P=0.325N P=0.172N P=0.278N P=0.626N | P=0.561N P=0.368N P=0.383N P=0.653N |
|LOGISTIC REGRESSION | P=0.390N P=0.166N P=0.316N P=0.622N | P=0.561N P=0.368N P=0.383N P=0.653N |
|COCHRAN-ARMITAGE | P=0.297N | P=0.461N |
|FISHER EXACT | P=0.122N P=0.309N P=0.309N | P=0.248N P=0.248N P=0.500N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Neurofibrosarcoma, Neurofibroma, or Schwannoma (benign, malignant or NOS) |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 2/60 (3%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 3.0% 0.0% 8.7% 0.0% | 0.0% 0.0% 0.0% 5.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 0/12 (0%) 1/17 (6%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 0/15 (0%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | 674 --- 632 --- | --- --- --- 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.643 P=0.564N P=0.460 P=0.737N | P=0.171 (e) (e) P=0.412 |
|INCIDENTAL TUMOR | P=0.514N P=0.522N P=0.534 P=0.576N | P=0.171 (e) (e) P=0.412 |
|LOGISTIC REGRESSION | P=0.571N P=0.520N P=0.489 P=0.605N | P=0.171 (e) (e) P=0.412 |
|COCHRAN-ARMITAGE | P=0.461N | P=0.198 |
|FISHER EXACT | P=0.500N P=0.500 P=0.500N | (e) (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 0/60 (0%) 2/60 (3%) 2/60 (3%) | 2/60 (3%) 0/60 (0%) 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | 23.5% 0.0% 7.7% 8.9% | 7.1% 0.0% 6.7% 11.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/17 (12%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 2/28 (7%) 0/16 (0%) 1/15 (7%) 2/18 (11%) |
|FIRST INCIDENCE (DAYS) | 686 --- 575 617 | 734 (T) --- 734 (T) 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.552 P=0.071N P=0.233N P=0.421 | P=0.345 P=0.368N P=0.713N P=0.528 |
|INCIDENTAL TUMOR | P=0.291N P=0.054N P=0.264N P=0.379N | P=0.345 P=0.368N P=0.713N P=0.528 |
|LOGISTIC REGRESSION | P=0.437N P=0.056N P=0.241N P=0.575N | P=0.345 P=0.368N P=0.713N P=0.528 |
|COCHRAN-ARMITAGE | P=0.264N | P=0.469 |
|FISHER EXACT | P=0.029N* P=0.219N P=0.219N | P=0.248N P=0.500N P=0.691N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 0/60 (0%) 1/60 (2%) 2/60 (3%) | 2/60 (3%) 0/60 (0%) 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | 19.0% 0.0% 2.2% 8.9% | 7.1% 0.0% 6.7% 11.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/17 (12%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 2/28 (7%) 0/16 (0%) 1/15 (7%) 2/18 (11%) |
|FIRST INCIDENCE (DAYS) | 686 --- 575 617 | 734 (T) --- 734 (T) 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.525 P=0.112N P=0.197N P=0.375 | P=0.345 P=0.368N P=0.713N P=0.528 |
|INCIDENTAL TUMOR | P=0.371N P=0.096N P=0.183N P=0.532N | P=0.345 P=0.368N P=0.713N P=0.528 |
|LOGISTIC REGRESSION | P=0.498N P=0.096N P=0.192N P=0.657N | P=0.345 P=0.368N P=0.713N P=0.528 |
|COCHRAN-ARMITAGE | P=0.374N | P=0.469 |
|FISHER EXACT | P=0.059N P=0.182N P=0.340N | P=0.248N P=0.500N P=0.691N |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 48/60 (80%) 47/60 (78%) 58/60 (97%) 57/60 (95%) | |
|ADJUSTED (b) | 93.6% 97.6% 100.0% 100.0% | |
|INTERIM SACRIFICE 1 (c)| 9/10 (90%) 7/10 (70%) 10/10 (100%) 10/10 (100%)| |
|TERMINAL (d) | 14/17 (82%) 11/12 (92%) 17/17 (100%) 1/1 (100%) | |
|FIRST INCIDENCE (DAYS) | 453 (I) 453 (I) 413 453 (I) | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.163 P=0.064 P<0.001 ** | |
|INCIDENTAL TUMOR | P<0.001 ** P=0.579N P=0.007 ** P=0.006 ** | |
|LOGISTIC REGRESSION | P<0.001 ** P=0.563N P=0.005 ** P=0.006 ** | |
|COCHRAN-ARMITAGE | P=0.002 ** | |
|FISHER EXACT | P=0.500N P=0.004 ** P=0.012 * | |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/60 (12%) 8/60 (13%) 5/60 (8%) 4/60 (7%) | 5/60 (8%) 9/60 (15%) 5/60 (8%) 2/60 (3%) |
|ADJUSTED (b) | 31.8% 37.3% 21.6% 20.6% | 16.7% 35.0% 22.7% 8.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/17 (18%) 3/12 (25%) 2/17 (12%) 0/1 (0%) | 4/28 (14%) 1/16 (6%) 2/15 (13%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | 707 533 631 571 | 698 523 587 579 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.283 P=0.286 P=0.437N P=0.128 | P=0.265N P=0.044 * P=0.316 P=0.420N |
|INCIDENTAL TUMOR | P=0.338N P=0.388 P=0.474N P=0.516N | P=0.175N P=0.086 P=0.472 P=0.334N |
|LOGISTIC REGRESSION | P=0.405N P=0.368 P=0.441N P=0.594 | P=0.189N P=0.072 P=0.465 P=0.388N |
|COCHRAN-ARMITAGE | P=0.154N | P=0.088N |
|FISHER EXACT | P=0.500 P=0.381N P=0.264N | P=0.197 P=0.628N P=0.219N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 4/60 (7%) 1/60 (2%) | 2/60 (3%) 2/60 (3%) 3/60 (5%) 2/60 (3%) |
|ADJUSTED (b) | 11.8% 8.3% 18.4% 3.8% | 7.1% 8.2% 20.0% 11.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/17 (12%) 1/12 (8%) 2/17 (12%) 0/1 (0%) | 2/28 (7%) 1/16 (6%) 3/15 (20%) 2/18 (11%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 733 (T) 658 617 | 734 (T) 468 734 (T) 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.204 P=0.623N P=0.307 P=0.508 | P=0.406 P=0.536 P=0.228 P=0.528 |
|INCIDENTAL TUMOR | P=0.346 P=0.623N P=0.279 P=0.750 | P=0.465 P=0.608 P=0.228 P=0.528 |
|LOGISTIC REGRESSION | P=0.393 P=0.623N P=0.290 P=0.739 | P=0.417 P=0.652 P=0.228 P=0.528 |
|COCHRAN-ARMITAGE | P=0.500N | P=0.568 |
|FISHER EXACT | P=0.500N P=0.340 P=0.500N | P=0.691N P=0.500 P=0.691N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/60 (13%) 9/60 (15%) 9/60 (15%) 5/60 (8%) | 7/60 (12%) 11/60 (18%) 7/60 (12%) 4/60 (7%) |
|ADJUSTED (b) | 36.7% 44.3% 37.2% 23.7% | 23.6% 40.6% 34.6% 19.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/17 (24%) 4/12 (33%) 4/17 (24%) 0/1 (0%) | 6/28 (21%) 2/16 (13%) 4/15 (27%) 3/18 (17%) |
|FIRST INCIDENCE (DAYS) | 707 533 631 571 | 698 468 587 579 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.105 P=0.263 P=0.433 P=0.073 | P=0.365N P=0.041 * P=0.215 P=0.548N |
|INCIDENTAL TUMOR | P=0.548N P=0.357 P=0.374 P=0.571N | P=0.252N P=0.088 P=0.333 P=0.477N |
|LOGISTIC REGRESSION | P=0.532 P=0.343 P=0.416 P=0.527 | P=0.281N P=0.086 P=0.375 P=0.551N |
|COCHRAN-ARMITAGE | P=0.208N | P=0.121N |
|FISHER EXACT | P=0.500 P=0.500 P=0.279N | P=0.222 P=0.611N P=0.264N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 6.2% 0.0% 3.6% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 453 (I) --- 664 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.298N P=0.268N P=0.533N P=0.401N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.236N P=0.252N P=0.588N P=0.281N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.184N P=0.228N P=0.501N P=0.216N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.189N | (e) |
|FISHER EXACT | P=0.248N P=0.500N P=0.248N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 1/60 (2%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 6.2% 0.0% 3.6% 0.0% | 0.0% 6.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 0/28 (0%) 1/16 (6%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 453 (I) --- 664 --- | --- 734 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.298N P=0.268N P=0.533N P=0.401N | P=0.619N P=0.388 (e) (e) |
|INCIDENTAL TUMOR | P=0.236N P=0.252N P=0.588N P=0.281N | P=0.619N P=0.388 (e) (e) |
|LOGISTIC REGRESSION | P=0.184N P=0.228N P=0.501N P=0.216N | P=0.619N P=0.388 (e) (e) |
|COCHRAN-ARMITAGE | P=0.189N | P=0.567N |
|FISHER EXACT | P=0.248N P=0.500N P=0.248N | P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 5.9% 8.3% 0.0% 0.0% | 6.8% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/17 (6%) 1/12 (8%) 0/17 (0%) 0/1 (0%) | 1/28 (4%) 0/16 (0%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 733 (T) --- --- | 721 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.463N P=0.684 P=0.500N P=0.974N | P=0.169N P=0.350N P=0.364N P=0.343N |
|INCIDENTAL TUMOR | P=0.463N P=0.684 P=0.500N P=0.974N | P=0.163N P=0.339N P=0.284N P=0.395N |
|LOGISTIC REGRESSION | P=0.463N P=0.684 P=0.500N P=0.974N | P=0.165N P=0.338N P=0.328N P=0.353N |
|COCHRAN-ARMITAGE | P=0.236N | P=0.115N |
|FISHER EXACT | P=0.752N P=0.500N P=0.500N | P=0.248N P=0.248N P=0.248N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 4/60 (7%) 0/60 (0%) 0/60 (0%) | 0/59 (0%) 0/60 (0%) 2/60 (3%) 0/59 (0%) |
|ADJUSTED (b) | 0.0% 16.3% 0.0% 0.0% | 0.0% 0.0% 10.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 1/12 (8%) 0/17 (0%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 1/15 (7%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- 453 (I) --- --- | --- --- 677 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.393N P=0.046 * (e) (e) | P=0.499 (e) P=0.134 (e) |
|INCIDENTAL TUMOR | P=0.267N P=0.066 (e) (e) | P=0.485 (e) P=0.196 (e) |
|LOGISTIC REGRESSION | P=0.245N P=0.066 (e) (e) | P=0.524 (e) P=0.185 (e) |
|COCHRAN-ARMITAGE | P=0.244N | P=0.594 |
|FISHER EXACT | P=0.061 (e) (e) | (e) P=0.252 (e) |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 6/60 (10%) 5/60 (8%) 6/60 (10%) 6/60 (10%) |
|ADJUSTED (b) | | 19.7% 24.2% 23.9% 19.3% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 2/10 (20%) 1/10 (10%) |
|TERMINAL (d) | | 5/28 (18%) 3/16 (19%) 2/15 (13%) 2/18 (11%) |
|FIRST INCIDENCE (DAYS) | | 626 583 454 (I) 439 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.289 P=0.405 P=0.295 P=0.370 |
|INCIDENTAL TUMOR | | P=0.419 P=0.617 P=0.425 P=0.537N |
|LOGISTIC REGRESSION | | P=0.414 P=0.544 P=0.542 P=0.534 |
|COCHRAN-ARMITAGE | | P=0.515 |
|FISHER EXACT | | P=0.500N P=0.619N P=0.619N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 26
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 6/60 (10%) 6/60 (10%) 6/60 (10%) 7/60 (12%) |
|ADJUSTED (b) | | 19.7% 26.9% 23.9% 21.9% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 2/10 (20%) 1/10 (10%) |
|TERMINAL (d) | | 5/28 (18%) 3/16 (19%) 2/15 (13%) 2/18 (11%) |
|FIRST INCIDENCE (DAYS) | | 626 583 454 (I) 439 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.212 P=0.270 P=0.295 P=0.253 |
|INCIDENTAL TUMOR | | P=0.377 P=0.562 P=0.425 P=0.592N |
|LOGISTIC REGRESSION | | P=0.334 P=0.421 P=0.542 P=0.417 |
|COCHRAN-ARMITAGE | | P=0.429 |
|FISHER EXACT | | P=0.619N P=0.619N P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 5/60 (8%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 2.3% 0.0% | 0.0% 0.0% 19.5% 5.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 576 --- | --- --- 589 703 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.679 (e) P=0.505 (e) | P=0.143 (e) P=0.013 * P=0.400 |
|INCIDENTAL TUMOR | P=0.675N (e) P=0.638 (e) | P=0.106 (e) P=0.059 P=0.318 |
|LOGISTIC REGRESSION | P=0.706 (e) P=0.495 (e) | P=0.171 (e) P=0.021 * P=0.428 |
|COCHRAN-ARMITAGE | P=0.695 | P=0.242 |
|FISHER EXACT | (e) P=0.500 (e) | (e) P=0.029 * P=0.500 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 27
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 5.2% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/17 (0%) 0/12 (0%) 0/17 (0%) 0/1 (0%) | 1/28 (4%) 0/16 (0%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 454 (I) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.143N P=0.300N P=0.307N P=0.288N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.143N P=0.300N P=0.307N P=0.288N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.104N P=0.209N P=0.212N P=0.207N |
|COCHRAN-ARMITAGE | (e) | P=0.115N |
|FISHER EXACT | (e) (e) (e) | P=0.248N P=0.248N P=0.248N |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 34/60 (57%) 43/60 (72%) 38/60 (63%) 32/60 (53%) | 16/60 (27%) 31/60 (52%) 23/60 (38%) 36/60 (60%) |
|ADJUSTED (b) | 81.5% 95.3% 91.9% 100.0% | 43.7% 76.5% 65.1% 82.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 10/17 (59%) 10/12 (83%) 14/17 (82%) 1/1 (100%) | 8/28 (29%) 7/16 (44%) 6/15 (40%) 11/18 (61%) |
|FIRST INCIDENCE (DAYS) | 509 351 413 453 (I) | 621 468 469 372 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.016 * P=0.231 P<0.001 ** | P<0.001 ** P<0.001 ** P=0.008 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.167N P=0.024 * P=0.376 P=0.307N | P<0.001 ** P=0.003 ** P=0.136 P<0.001 ** |
|LOGISTIC REGRESSION | P=0.144N P=0.029 * P=0.391 P=0.130N | P<0.001 ** P=0.002 ** P=0.105 P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.203N | P=0.001 ** |
|FISHER EXACT | P=0.064 P=0.288 P=0.427N | P=0.004 ** P=0.121 P<0.001 ** |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 28
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 1/60 (2%) 2/60 (3%) 2/60 (3%) | 0/60 (0%) 1/60 (2%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 15.0% 3.8% 9.5% 3.9% | 0.0% 1.7% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/17 (6%) 0/12 (0%) 1/17 (6%) 0/1 (0%) | 0/28 (0%) 0/16 (0%) 0/15 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 489 664 674 453 (I) | --- 413 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.464N P=0.154N P=0.253N P=0.450N | P=0.574N P=0.497 (e) (e) |
|INCIDENTAL TUMOR | P=0.227N P=0.080N P=0.220N P=0.129N | P=0.402N P=0.638 (e) (e) |
|LOGISTIC REGRESSION | P=0.220N P=0.105N P=0.219N P=0.180N | P=0.417N P=0.665 (e) (e) |
|COCHRAN-ARMITAGE | P=0.223N | P=0.567N |
|FISHER EXACT | P=0.103N P=0.219N P=0.219N | P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 59/60 (98%) 57/60 (95%) 60/60 (100%) 59/60 (98%) | 47/60 (78%) 46/60 (77%) 46/60 (77%) 43/60 (72%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 95.8% 97.7% 100.0% 95.3% |
|INTERIM SACRIFICE 1 (c)| 10/10 (100%) 9/10 (90%) 10/10 (100%) 10/10 (100%)| 1/10 (10%) 3/10 (30%) 3/10 (30%) 3/10 (30%) |
|TERMINAL (d) | 17/17 (100%) 12/12 (100%) 17/17 (100%) 1/1 (100%) | 26/28 (93%) 15/16 (94%) 15/15 (100%) 16/18 (89%) |
|FIRST INCIDENCE (DAYS) | 336 351 413 361 | 454 (I) 413 387 433 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.160 P=0.365 P<0.001 ** | P=0.057 P=0.009 ** P=0.008 ** P=0.035 * |
|INCIDENTAL TUMOR | P=0.321 P=0.367N P=0.638 P=0.603 | P=0.451N P=0.491 P=0.418 P=0.528N |
|LOGISTIC REGRESSION | P=0.378 P=0.321N P=0.903 P=0.720N | P=0.415 P=0.278 P=0.326 P=0.377 |
|COCHRAN-ARMITAGE | P=0.410 | P=0.222N |
|FISHER EXACT | P=0.309N P=0.500 P=0.752N | P=0.500N P=0.500N P=0.264N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 29
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 156 PPM 312 PPM 625 PPM | CONTROL 312 PPM 625 PPM 1250 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 41/60 (68%) 46/60 (77%) 49/60 (82%) 39/60 (65%) | 22/60 (37%) 42/60 (70%) 35/60 (58%) 43/60 (72%) |
|ADJUSTED (b) | 88.3% 97.8% 98.0% 100.0% | 53.4% 93.1% 83.9% 91.2% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 0/10 (0%) 1/10 (10%) 4/10 (40%) | 1/10 (10%) 1/10 (10%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 12/17 (71%) 11/12 (92%) 16/17 (94%) 1/1 (100%) | 10/28 (36%) 13/16 (81%) 9/15 (60%) 14/18 (78%) |
|FIRST INCIDENCE (DAYS) | 453 (I) 351 413 453 (I) | 433 413 387 372 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.046 * P=0.113 P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.281N P=0.137 P=0.058 P=0.310N | P<0.001 ** P<0.001 ** P=0.015 * P<0.001 ** |
|LOGISTIC REGRESSION | P=0.246N P=0.144 P=0.077 P=0.166N | P<0.001 ** P<0.001 ** P=0.003 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.302N | P=0.001 ** |
|FISHER EXACT | P=0.207 P=0.070 P=0.423N | P<0.001 ** P=0.014 * P<0.001 ** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 59/60 (98%) 58/60 (97%) 60/60 (100%) 59/60 (98%) | 50/60 (83%) 54/60 (90%) 52/60 (87%) 51/60 (85%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 98.0% 100.0% 100.0% 98.0% |
|INTERIM SACRIFICE 1 (c)| 10/10 (100%) 9/10 (90%) 10/10 (100%) 10/10 (100%)| 1/10 (10%) 4/10 (40%) 3/10 (30%) 3/10 (30%) |
|TERMINAL (d) | 17/17 (100%) 12/12 (100%) 17/17 (100%) 1/1 (100%) | 27/28 (96%) 16/16 (100%) 15/15 (100%) 17/18 (94%) |
|FIRST INCIDENCE (DAYS) | 336 351 413 361 | 433 247 387 372 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.130 P=0.365 P<0.001 ** | P=0.016 * P=0.001 ** P=0.002 ** P=0.005 ** |
|INCIDENTAL TUMOR | P=0.366 P=0.596N P=0.638 P=0.603 | P=0.542 P=0.108 P=0.206 P=0.402 |
|LOGISTIC REGRESSION | P=0.534 P=0.477N P=0.903 P=0.720N | P=0.135 P=0.032 * P=0.104 P=0.072 |
|COCHRAN-ARMITAGE | P=0.500 | P=0.538N |
|FISHER EXACT | P=0.500N P=0.500 P=0.752N | P=0.211 P=0.399 P=0.500 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05132 TEST: 05 PAGE 30
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 453
Female interim sacrifices(days): 454
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).