TDMS Study 05132-05 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
TETRAFLUOROETHYLENE (TFE)
NTP Experiment-Test: 05132-05 Report: PEIRPT09
Study Type: CHRONIC Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 116-14-3
Lock Date: 08/25/92
Cage Range: All
Reasons For Removal: 25008 Accident 25022 Accidently Killed
25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 002 CONTROL
Include 005 312 PPM
Include 007 625 PPM
Include 008 1250 PPM
Include 001 CONTROL
Include 003 156 PPM
Include 004 312 PPM
Include 006 625 PPM
Page 1
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 9| 3| 3| 1| 0| 3| 9| 6| 3| 8| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 4| 4|
| 4| 4| 3| 4| 4| 4| 7| 4| 9| 3| 4| 1| 4| 4| 5| 4| 2| 4| 4| 4| 4| 4| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 6| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Infiltration Cellular, Eosinophil | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Degeneration, Cystic | |
Eosinophilic Focus | |
Fatty Change | 2 3 3 2 1 2 2 |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X X X X X X X X X |
Necrosis, Focal | 1 |
Regeneration | |
Bile Duct, Hyperplasia | 1 1 2 1 |
__________________________________________________________________________|
Mesentery | + + + + + |
Polyarteritis | |
Fat, Necrosis | 3 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Hyperplasia | |
Acinus, Atrophy | 1 1 1 1 2 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 2 1 |
Necrosis | 2 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Necrosis | 3 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 3 1 2 1 2 1 1 2 1 1 1 1 1 1|
Polyarteritis | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 9| 3| 3| 1| 0| 3| 9| 6| 3| 8| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 4| 4|
| 4| 4| 3| 4| 4| 4| 7| 4| 9| 3| 4| 1| 4| 4| 5| 4| 2| 4| 4| 4| 4| 4| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 6| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 1 2 1 2 |
Hypertrophy | 2 2 2 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 2 2 2 2 3 2 2 2 1 3 3 3 1 2 1 1 2 2 2 3 1 1|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia | |
Inflammation, Chronic Active | 1 |
Duct, Ectasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 9| 3| 3| 1| 0| 3| 9| 6| 3| 8| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 4| 4|
| 4| 4| 3| 4| 4| 4| 7| 4| 9| 3| 4| 1| 4| 4| 5| 4| 2| 4| 4| 4| 4| 4| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 6| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 1 1 1 1 1 |
Metaplasia, Squamous | 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 1 1 1 |
Infiltration Cellular, Lymphocyte | |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic Active | 1 2 |
Alveolar Epithelium, Hyperplasia | 1 2 1 4 |
Mediastinum, Polyarteritis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 2 1 2 4 4 1 1 1 |
Degeneration | 3 3 |
Hemorrhage | 2 2 |
Cornea, Inflammation, Chronic Active | |
Cornea, Mineralization | 1|
Retina, Atrophy | 3 3 2 2 4 4 3 1 1 |
Retina, Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 9| 3| 3| 1| 0| 3| 9| 6| 3| 8| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 4| 4|
| 4| 4| 3| 4| 4| 4| 7| 4| 9| 3| 4| 1| 4| 4| 5| 4| 2| 4| 4| 4| 4| 4| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 6| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 1 1 2 3 1 3 1 1 1 1 2 2 2 2 3 2 3 2 2 3 2 1 1|
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + M +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 4| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 0| 3| 3| 2| 2| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 2| 3| 8| 3| 7| 0| 3| 2| |
| 8| 2| 4| 4| 6| 6| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 1| 1| 4| 1| 4| 7| 7| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | | 1 2.0|
Parasite Metazoan | X X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | 2 | 1 2.0|
Infiltration Cellular, Eosinophil | 3 | 1 3.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X | 41 |
Clear Cell Focus | X X X X X X | 10 |
Degeneration, Cystic | 2 | 1 2.0|
Eosinophilic Focus | X | 1 |
Fatty Change | 2 3 1 1 1 1 1 1| 15 1.7|
Hepatodiaphragmatic Nodule | X | 3 |
Mixed Cell Focus | X X X | 12 |
Necrosis, Focal | | 1 1.0|
Regeneration | 1 | 1 1.0|
Bile Duct, Hyperplasia | 2 2 1 1 1 | 9 1.3|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Polyarteritis | 2 | 1 2.0|
Fat, Necrosis | | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 3 |
Hyperplasia | 2 | 1 2.0|
Acinus, Atrophy | 1 1 1 1 2 1 1 1| 15 1.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 4 1.8|
Necrosis | 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 2.0|
Necrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Tongue | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 4| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 0| 3| 3| 2| 2| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 2| 3| 8| 3| 7| 0| 3| 2| |
| 8| 2| 4| 4| 6| 6| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 1| 1| 4| 1| 4| 7| 7| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 1 1 2 1 2 1 2 2 2 2 1 1 1 1 1 2 2 1 1 2 1| 41 1.5|
Polyarteritis | 2 | 1 2.0|
Atrium, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 2 2 1 1 2 2 1 | 18 1.6|
Hypertrophy | 2 | 4 2.0|
Vacuolization Cytoplasmic | 2 2 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 6 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Hemorrhage | 4 | 1 4.0|
Pars Distalis, Hyperplasia | 2 1 4 1 | 4 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 3 2 2 1 1 1 2 1 1 1 2 1 2 1 2 2 2 1 1 2 2 1 2 1| 48 1.8|
Follicular Cell, Hyperplasia | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 3 | 1 3.0|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 3 | 2 2.0|
Duct, Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 4| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 0| 3| 3| 2| 2| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 2| 3| 8| 3| 7| 0| 3| 2| |
| 8| 2| 4| 4| 6| 6| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 1| 1| 4| 1| 4| 7| 7| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + | 3 |
Renal, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | X X X X X| 6 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X X X X X X X X X| 30 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 1 1 1 | 13 1.2|
Metaplasia, Squamous | 1 | 2 1.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 31 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 1 1 1 1 1 1 | 17 1.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 1 | 2 1.5|
Inflammation, Chronic Active | | 2 1.5|
Alveolar Epithelium, Hyperplasia | 1 1 2 1 | 8 1.6|
Mediastinum, Polyarteritis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 4| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 0| 3| 3| 2| 2| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 2| 3| 8| 3| 7| 0| 3| 2| |
| 8| 2| 4| 4| 6| 6| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 1| 1| 4| 1| 4| 7| 7| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cataract | 1 3 2 1 1 2 2 | 15 1.9|
Degeneration | | 2 3.0|
Hemorrhage | 4 | 3 2.7|
Cornea, Inflammation, Chronic Active | 1 | 1 1.0|
Cornea, Mineralization | | 1 1.0|
Retina, Atrophy | 1 1 3 3 2 3 3 3 3 3 3 1| 21 2.5|
Retina, Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 33 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 2 3 1 1 1 1 3 1 2 2 1 1 1 1 1 1 2 1 1 2 1 3 2| 48 1.7|
Renal Tubule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 5| 5| 4| 6| 5| 5| 7| 7| 6| 7| 6| 6| 7| 5| 6| 7| 6| 6| 5| 4| 7|
DAY ON TEST | 2| 3| 7| 0| 1| 6| 6| 7| 9| 3| 3| 3| 3| 2| 9| 1| 3| 7| 1| 3| 0| 2| 6| 1| 3|
| 2| 5| 4| 4| 7| 5| 8| 5| 4| 7| 0| 5| 8| 3| 1| 8| 5| 4| 8| 5| 0| 5| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
| 2| 3| 4| 5| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 1 2 2 3 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Degeneration, Cystic | 1 |
Eosinophilic Focus | X X X |
Fatty Change | 4 2 3 1 1 3 3 1 2 2 2 |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X X X X X X X X X|
Regeneration | 3 |
Bile Duct, Hyperplasia | 2 1 2 2 1 1 3 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Metaplasia | 1 |
Acinus, Atrophy | 1 1 2 1 2 1 4 1 1 2|
__________________________________________________________________________|
Pharynx | + |
Palate, Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 2 |
Diverticulum | |
Mineralization | |
Necrosis | 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 2 1 1 1 1 1 1 1 1 1 2 2 2 2 3|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 5| 5| 4| 6| 5| 5| 7| 7| 6| 7| 6| 6| 7| 5| 6| 7| 6| 6| 5| 4| 7|
DAY ON TEST | 2| 3| 7| 0| 1| 6| 6| 7| 9| 3| 3| 3| 3| 2| 9| 1| 3| 7| 1| 3| 0| 2| 6| 1| 3|
| 2| 5| 4| 4| 7| 5| 8| 5| 4| 7| 0| 5| 8| 3| 1| 8| 5| 4| 8| 5| 0| 5| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
| 2| 3| 4| 5| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hyperplasia | 2 2 |
Hypertrophy | 3 2 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 3 2 1 2 1 1 1 3 1 1 3 2 3 1 1 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | 1 1 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + |
Lumbar, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Infiltration Cellular, Lipocyte | 2 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 5| 5| 4| 6| 5| 5| 7| 7| 6| 7| 6| 6| 7| 5| 6| 7| 6| 6| 5| 4| 7|
DAY ON TEST | 2| 3| 7| 0| 1| 6| 6| 7| 9| 3| 3| 3| 3| 2| 9| 1| 3| 7| 1| 3| 0| 2| 6| 1| 3|
| 2| 5| 4| 4| 7| 5| 8| 5| 4| 7| 0| 5| 8| 3| 1| 8| 5| 4| 8| 5| 0| 5| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
| 2| 3| 4| 5| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X X X X|
Hemorrhage | 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 2 1 |
Metaplasia, Squamous | 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 |
Inflammation, Chronic Active | 1 2|
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 3 4 1 |
Degeneration | |
Hemorrhage | 1 3 2 |
Cornea, Inflammation, Chronic Active | 1 1 |
Cornea, Mineralization | 1 1 |
Retina, Atrophy | 3 4 3 2 2 4 |
Retina, Degeneration | 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 5| 5| 4| 6| 5| 5| 7| 7| 6| 7| 6| 6| 7| 5| 6| 7| 6| 6| 5| 4| 7|
DAY ON TEST | 2| 3| 7| 0| 1| 6| 6| 7| 9| 3| 3| 3| 3| 2| 9| 1| 3| 7| 1| 3| 0| 2| 6| 1| 3|
| 2| 5| 4| 4| 7| 5| 8| 5| 4| 7| 0| 5| 8| 3| 1| 8| 5| 4| 8| 5| 0| 5| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
| 2| 3| 4| 5| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 2 1 2 1 2 2 2 2 1 1 1 1 1 1 1 1 3 1 1 1 1 2|
Papilla, Necrosis | 3 |
Pelvis, Dilatation | 3 |
Renal Tubule, Hyperplasia | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 4| 5| 5| 2| 7| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 3| 5| 3| 2| 3| 8| 3| 3| 3| 3| 3| 1| 6| 8| 8| 4| 0| 3| 0| 3| 4| 3| 3| 5| |
| 7| 5| 7| 5| 3| 5| 8| 5| 5| 5| 0| 5| 7| 8| 1| 3| 7| 1| 4| 7| 5| 9| 5| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 1 | 9 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 38 |
Clear Cell Focus | X | 3 |
Degeneration, Cystic | 1 1 1 | 4 1.0|
Eosinophilic Focus | X | 4 |
Fatty Change | 2 2 2 1 2 1 2 3 3 | 20 2.1|
Hepatodiaphragmatic Nodule | X X X | 5 |
Mixed Cell Focus | X X X X X | 14 |
Regeneration | 3 | 2 3.0|
Bile Duct, Hyperplasia | 2 2 1 1 1 1 1 2 2 | 18 1.5|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis | 2 | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Metaplasia | | 1 1.0|
Acinus, Atrophy | 1 1 2 1 | 14 1.5|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 | 4 2.3|
Diverticulum | 2 | 1 2.0|
Mineralization | 2 | 1 2.0|
Necrosis | 1 3 | 4 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 4| 5| 5| 2| 7| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 3| 5| 3| 2| 3| 8| 3| 3| 3| 3| 3| 1| 6| 8| 8| 4| 0| 3| 0| 3| 4| 3| 3| 5| |
| 7| 5| 7| 5| 3| 5| 8| 5| 5| 5| 0| 5| 7| 8| 1| 3| 7| 1| 4| 7| 5| 9| 5| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1 1 2 2 1 1 2 1 1 2 1 1 2 1 2 1 2 1| 40 1.4|
Atrium, Thrombosis | X| 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Hyperplasia | 1 1 2 2 2 2 1 1 2 | 11 1.6|
Hypertrophy | 3 2 | 4 2.5|
Vacuolization Cytoplasmic | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 1 1 2 | 9 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 3 4 2 1 | 8 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 1 1 1 1 3 1 1 2 3 1 1 3 3 2 3 2 2| 40 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active | 2 | 4 1.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 4 3 4 | 3 3.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 7 |
Lumbar, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 4| 5| 5| 2| 7| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 3| 5| 3| 2| 3| 8| 3| 3| 3| 3| 3| 1| 6| 8| 8| 4| 0| 3| 0| 3| 4| 3| 3| 5| |
| 7| 5| 7| 5| 3| 5| 8| 5| 5| 5| 0| 5| 7| 8| 1| 3| 7| 1| 4| 7| 5| 9| 5| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Hemorrhage | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 4.0|
Infiltration Cellular, Lipocyte | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | X X X X | 14 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X X X X X X X | 23 |
Hemorrhage | | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 1 1 2 1 1 | 14 1.2|
Metaplasia, Squamous | | 1 1.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 1 1 1 | 8 1.0|
Inflammation, Chronic Active | 1 | 3 1.3|
Alveolar Epithelium, Hyperplasia | 2 1 1 | 4 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | 3 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 4| 5| 5| 2| 7| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 3| 5| 3| 2| 3| 8| 3| 3| 3| 3| 3| 1| 6| 8| 8| 4| 0| 3| 0| 3| 4| 3| 3| 5| |
| 7| 5| 7| 5| 3| 5| 8| 5| 5| 5| 0| 5| 7| 8| 1| 3| 7| 1| 4| 7| 5| 9| 5| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cataract | 2 | 4 2.5|
Degeneration | 3 | 1 3.0|
Hemorrhage | | 3 2.0|
Cornea, Inflammation, Chronic Active | | 2 1.0|
Cornea, Mineralization | | 2 1.0|
Retina, Atrophy | 3 3 1 3 2 | 11 2.7|
Retina, Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 23 1.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 2 2 1 2 2 2 1 2 2 2 2 2 1 1 1 1 1 2 2 1 1 2 2| 46 1.5|
Papilla, Necrosis | | 1 3.0|
Pelvis, Dilatation | | 1 3.0|
Renal Tubule, Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 5| 7| 7| 3| 6| 7| 5| 6| 6| 7| 5| 4| 7| 6| 7| 7| 6| 4| 7| 7| 6|
DAY ON TEST | 5| 0| 3| 6| 3| 3| 3| 8| 9| 3| 0| 0| 9| 3| 3| 6| 3| 9| 0| 3| 6| 7| 3| 3| 8|
| 3| 7| 5| 8| 4| 3| 5| 7| 9| 5| 4| 8| 8| 5| 6| 9| 5| 8| 2| 5| 8| 8| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X |
Degeneration, Cystic | |
Eosinophilic Focus | X |
Fatty Change | 2 2 2 2 1 2 1 2|
Hepatodiaphragmatic Nodule | X X X X X X |
Mitotic Alteration | |
Mixed Cell Focus | X X X X X X X X X |
Necrosis, Focal | 2 |
Regeneration | |
Bile Duct, Hyperplasia | 1 1 2|
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + |
Polyarteritis | |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Acinus, Atrophy | 1 1 1 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + M + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + M + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Tongue | + + |
Hyperplasia, Squamous | 4 |
Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 5| 7| 7| 3| 6| 7| 5| 6| 6| 7| 5| 4| 7| 6| 7| 7| 6| 4| 7| 7| 6|
DAY ON TEST | 5| 0| 3| 6| 3| 3| 3| 8| 9| 3| 0| 0| 9| 3| 3| 6| 3| 9| 0| 3| 6| 7| 3| 3| 8|
| 3| 7| 5| 8| 4| 3| 5| 7| 9| 5| 4| 8| 8| 5| 6| 9| 5| 8| 2| 5| 8| 8| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 1 1 1 1 1 2 1 1 1 2 3 3 2 1 1 2 3 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 |
Hypertrophy | 2 |
Metaplasia, Osseous | 3 |
Necrosis | |
Vacuolization Cytoplasmic | 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1 1 1 2 1 2 2 1 2 1 1 2 1 2 2 1 2 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 1 1 2 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + +|
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 5| 7| 7| 3| 6| 7| 5| 6| 6| 7| 5| 4| 7| 6| 7| 7| 6| 4| 7| 7| 6|
DAY ON TEST | 5| 0| 3| 6| 3| 3| 3| 8| 9| 3| 0| 0| 9| 3| 3| 6| 3| 9| 0| 3| 6| 7| 3| 3| 8|
| 3| 7| 5| 8| 4| 3| 5| 7| 9| 5| 4| 8| 8| 5| 6| 9| 5| 8| 2| 5| 8| 8| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis | |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 2 2 1 1|
Metaplasia, Squamous | 2 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 3 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 2 4 3 2 1 2 |
Degeneration | 4 4 |
Hemorrhage | 3|
Cornea, Mineralization | 1 |
Retina, Atrophy | 3 1 1 3 4 4 2 3|
Retina, Degeneration | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 3 3 2 4 1 1 1 2 1 2 2 2 1 1 2 1 1 2 1 1 3 2 2|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 5| 7| 7| 3| 6| 7| 5| 6| 6| 7| 5| 4| 7| 6| 7| 7| 6| 4| 7| 7| 6|
DAY ON TEST | 5| 0| 3| 6| 3| 3| 3| 8| 9| 3| 0| 0| 9| 3| 3| 6| 3| 9| 0| 3| 6| 7| 3| 3| 8|
| 3| 7| 5| 8| 4| 3| 5| 7| 9| 5| 4| 8| 8| 5| 6| 9| 5| 8| 2| 5| 8| 8| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Degeneration | 1 1 1 3 1 1 1 1 1 2 1 1 1 2 |
Renal Tubule, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 6| 7| 6| 7| 5| 6| 3| 6| 7| 7| 7| 4| 5| 5| 6| 6| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 8| 3| 7| 2| 3| 7| 3| 8| 6| 6| 1| 3| 3| 1| 7| 4| 8| 7| 5| 3| 2| 8| 3| |
| 5| 5| 7| 3| 2| 5| 5| 7| 5| 7| 4| 3| 1| 5| 5| 6| 7| 4| 9| 4| 2| 3| 9| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
625 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 8| 0| 1| 2| 4| 5| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Cyst | X | 1 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + I + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 2 2 3| 9 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 41 |
Clear Cell Focus | X X X X X| 12 |
Degeneration, Cystic | 2| 1 2.0|
Eosinophilic Focus | X X X X| 5 |
Fatty Change | 2 3 2 2 1 1 1 1 2 | 17 1.7|
Hepatodiaphragmatic Nodule | X X X X| 10 |
Mitotic Alteration | 3 | 1 3.0|
Mixed Cell Focus | X X X X X X X| 16 |
Necrosis, Focal | 1 | 2 1.5|
Regeneration | 3 2 3 | 3 2.7|
Bile Duct, Hyperplasia | 2 2 1 1 3 2 2 2 2 | 12 1.8|
Centrilobular, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Polyarteritis | 3 | 1 3.0|
Fat, Necrosis | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Basophilic Focus | X| 2 |
Acinus, Atrophy | 1 4 1| 9 1.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
Acanthosis | 2 | 1 2.0|
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | | 1 2.0|
Necrosis | 1 | 2 1.5|
__________________________________________________________________________|____________|
Tongue | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 6| 7| 6| 7| 5| 6| 3| 6| 7| 7| 7| 4| 5| 5| 6| 6| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 8| 3| 7| 2| 3| 7| 3| 8| 6| 6| 1| 3| 3| 1| 7| 4| 8| 7| 5| 3| 2| 8| 3| |
| 5| 5| 7| 3| 2| 5| 5| 7| 5| 7| 4| 3| 1| 5| 5| 6| 7| 4| 9| 4| 2| 3| 9| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
625 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 8| 0| 1| 2| 4| 5| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Squamous | | 1 4.0|
Epithelium, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 2 1 3 2 2 1 1 1 1 2 2 1 1 1 2 2 1 2| 40 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1 2 1 2 2 1 2 1 4 2| 16 1.6|
Hypertrophy | 3 1 | 3 2.0|
Metaplasia, Osseous | | 1 3.0|
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 1 2 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 3 3 3 1 2 2 | 8 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 2 1 3 1 2 3 3 1 3 1 3 2 1 3 2 3 3 3 1 | 41 1.8|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 2 3 1 | 7 1.6|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 6| 7| 6| 7| 5| 6| 3| 6| 7| 7| 7| 4| 5| 5| 6| 6| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 8| 3| 7| 2| 3| 7| 3| 8| 6| 6| 1| 3| 3| 1| 7| 4| 8| 7| 5| 3| 2| 8| 3| |
| 5| 5| 7| 3| 2| 5| 5| 7| 5| 7| 4| 3| 1| 5| 5| 6| 7| 4| 9| 4| 2| 3| 9| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
625 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 8| 0| 1| 2| 4| 5| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Renal, Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Plasma Cell | 3 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Angiectasis | 4 | 1 4.0|
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3| 4 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | X X | 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X X | 20 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 1 2 1 1 1 2 2 | 14 1.5|
Metaplasia, Squamous | 2 | 2 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 31 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 1 1 1 1| 12 1.1|
Alveolar Epithelium, Hyperplasia | 3 2 1| 9 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 2 2 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 6| 7| 6| 7| 5| 6| 3| 6| 7| 7| 7| 4| 5| 5| 6| 6| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 8| 3| 7| 2| 3| 7| 3| 8| 6| 6| 1| 3| 3| 1| 7| 4| 8| 7| 5| 3| 2| 8| 3| |
| 5| 5| 7| 3| 2| 5| 5| 7| 5| 7| 4| 3| 1| 5| 5| 6| 7| 4| 9| 4| 2| 3| 9| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
625 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 8| 0| 1| 2| 4| 5| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cataract | 1 2 2 1 | 10 2.0|
Degeneration | 4 | 3 4.0|
Hemorrhage | 1 | 2 2.0|
Cornea, Mineralization | 1 | 2 1.0|
Retina, Atrophy | 3 1 1 3 3 3 2 | 15 2.5|
Retina, Degeneration | 1 1 1 1 1 1| 14 1.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 3 1 1 1 2 1 2 2 2 1 1 1 2 3 1 1 1 1 2 2 2 2 2 2| 48 1.7|
Renal Tubule, Degeneration | 2 1 1 1 1 2 1 1 2 2 1 1 1 2 1 1 1 1 1 1 1| 35 1.3|
Renal Tubule, Hyperplasia | 1 2 1 | 6 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 6| 6| 7| 5| 7| 7| 5| 7| 7| 4| 4| 5| 7| 7| 6| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 7| 3| 3| 7| 3| 0| 8| 6| 7| 3| 3| 0| 3| 3| 7| 7| 2| 3| 2| 3| 3| 3|
| 3| 9| 4| 9| 4| 4| 6| 4| 3| 1| 1| 2| 4| 4| 3| 4| 4| 7| 8| 7| 3| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1250 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 2 2 1 1 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X |
Degeneration, Cystic | 1 2 4 |
Embolus Bacterial | X |
Eosinophilic Focus | X X |
Fatty Change | 1 1 2 2 1 1 |
Hepatodiaphragmatic Nodule | X X X X |
Mixed Cell Focus | X X X X X X X X X|
Regeneration | 2 3 2 3 2 |
Bile Duct, Hyperplasia | 1 2 1 1 2 2 2 1 1 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Acinus, Atrophy | 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Necrosis | |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 1 1 1 2 3 2 2 1 2 3 2 2 1 2 2 3|
Embolus Bacterial | X |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 6| 6| 7| 5| 7| 7| 5| 7| 7| 4| 4| 5| 7| 7| 6| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 7| 3| 3| 7| 3| 0| 8| 6| 7| 3| 3| 0| 3| 3| 7| 7| 2| 3| 2| 3| 3| 3|
| 3| 9| 4| 9| 4| 4| 6| 4| 3| 1| 1| 2| 4| 4| 3| 4| 4| 7| 8| 7| 3| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1250 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | X |
Hyperplasia | 3 2 1 1 1 2 1 2|
Hypertrophy | 2 2 |
Vacuolization Cytoplasmic | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | X |
Hyperplasia | 2 1 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + M M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 3 4 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 2 2 1 1 2 1 1 2 1 1 1 3 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Renal, Hemorrhage | 2 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 6| 6| 7| 5| 7| 7| 5| 7| 7| 4| 4| 5| 7| 7| 6| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 7| 3| 3| 7| 3| 0| 8| 6| 7| 3| 3| 0| 3| 3| 7| 7| 2| 3| 2| 3| 3| 3|
| 3| 9| 4| 9| 4| 4| 6| 4| 3| 1| 1| 2| 4| 4| 3| 4| 4| 7| 8| 7| 3| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1250 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X X |
Tibia, Fracture | |
Turbinate, Fracture | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X X X X|
Embolus Bacterial | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 1 2 2 2 1 1 2 1|
Metaplasia, Squamous | 2 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 |
Infiltration Cellular, Histiocyte | 3 1 |
Inflammation, Chronic Active | |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 1 1 |
Thrombosis | X |
Nares, Inflammation, Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 2 2 3 3 3 3 2 3 3 1 3 3 3 3 3 3 2 2 2 4 2 3 2 3 3|
Degeneration | 4 |
Hemorrhage | 3 2 |
Cornea, Mineralization | 1 |
Retina, Atrophy | 3 2 2 4 1 3 3 2 4 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 6| 6| 7| 5| 7| 7| 5| 7| 7| 4| 4| 5| 7| 7| 6| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 7| 3| 3| 7| 3| 0| 8| 6| 7| 3| 3| 0| 3| 3| 7| 7| 2| 3| 2| 3| 3| 3|
| 3| 9| 4| 9| 4| 4| 6| 4| 3| 1| 1| 2| 4| 4| 3| 4| 4| 7| 8| 7| 3| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1250 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retina, Degeneration | 2 1 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Zymbal's Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | X |
Hyperplasia, Atypical | 1 |
Nephropathy | 2 3 2 2 2 1 2 1 1 1 2 3 3 3 4 1 3 2 1 1 2 2 2|
Pelvis, Dilatation | |
Renal Tubule, Degeneration | 3 4 2 1 2 2 1 1 1 1 1 3 3 3 3 3 2 3 2 1 3 2 3|
Renal Tubule, Hyperplasia | 2 2 1 3 2 4 |
Renal Tubule, Hyperplasia, Oncocytic | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 3| 5| 6| 7| 5| 5| 6| 6| 6| 0| 4| 6| 7| 5| 7| 7| 5| 7| 6| 7| 5| 3| 7| 6| |
DAY ON TEST | 0| 7| 1| 3| 3| 3| 8| 2| 1| 2| 0| 3| 0| 3| 9| 3| 3| 3| 3| 6| 3| 0| 7| 3| 2| |
| 9| 8| 8| 5| 4| 1| 3| 1| 0| 1| 6| 9| 8| 4| 4| 4| 4| 8| 4| 8| 4| 4| 2| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1250 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 2 1 1 2 | 14 1.6|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X | 37 |
Clear Cell Focus | X X X X | 9 |
Degeneration, Cystic | | 3 2.3|
Embolus Bacterial | | 1 |
Eosinophilic Focus | X X| 4 |
Fatty Change | 1 2 1 2 | 10 1.4|
Hepatodiaphragmatic Nodule | X | 5 |
Mixed Cell Focus | X X X X X X X X X | 18 |
Regeneration | 3 3 2 | 8 2.5|
Bile Duct, Hyperplasia | 2 1 1 1 1 2 2 1 2| 18 1.4|
Centrilobular, Necrosis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Fat, Necrosis | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Acinus, Atrophy | 1 1 2 2 2 1 | 9 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 2 1.5|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Epithelium, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 3| 5| 6| 7| 5| 5| 6| 6| 6| 0| 4| 6| 7| 5| 7| 7| 5| 7| 6| 7| 5| 3| 7| 6| |
DAY ON TEST | 0| 7| 1| 3| 3| 3| 8| 2| 1| 2| 0| 3| 0| 3| 9| 3| 3| 3| 3| 6| 3| 0| 7| 3| 2| |
| 9| 8| 8| 5| 4| 1| 3| 1| 0| 1| 6| 9| 8| 4| 4| 4| 4| 8| 4| 8| 4| 4| 2| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1250 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 2 2 2 3 2 2 1 | 33 1.7|
Embolus Bacterial | | 1 |
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Embolus Bacterial | | 1 |
Hyperplasia | 2 2 2 1 1 2 2 1 1 1 1 2 1 1 | 22 1.5|
Hypertrophy | 1 2 2 | 5 1.8|
Vacuolization Cytoplasmic | 2 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Embolus Bacterial | | 1 |
Hyperplasia | 2 2 2 | 8 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 2 1 2 2 1 4 4 2 | 13 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 2 1 1 1 1 3 1 1 1 2 3 1 1 2 2| 38 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M + M + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 4 2 | 2 3.0|
Inflammation, Chronic Active | 3 | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + +| 13 |
Renal, Hemorrhage | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 3| 5| 6| 7| 5| 5| 6| 6| 6| 0| 4| 6| 7| 5| 7| 7| 5| 7| 6| 7| 5| 3| 7| 6| |
DAY ON TEST | 0| 7| 1| 3| 3| 3| 8| 2| 1| 2| 0| 3| 0| 3| 9| 3| 3| 3| 3| 6| 3| 0| 7| 3| 2| |
| 9| 8| 8| 5| 4| 1| 3| 1| 0| 1| 6| 9| 8| 4| 4| 4| 4| 8| 4| 8| 4| 4| 2| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1250 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Plasma Cell | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Embolus Bacterial | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + + + + + + M + M + + + M + + + + + + +| 45 |
Hemorrhage | 1 1| 2 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Fibrosis | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + M| 48 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 3 |
Tibia, Fracture | X | 1 |
Turbinate, Fracture | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X X X| 19 |
Embolus Bacterial | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 1 2 1 3 2 1 1 1 2| 21 1.5|
Metaplasia, Squamous | 1 2| 4 1.5|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 30 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 | 5 1.0|
Infiltration Cellular, Histiocyte | | 2 2.0|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 3| 5| 6| 7| 5| 5| 6| 6| 6| 0| 4| 6| 7| 5| 7| 7| 5| 7| 6| 7| 5| 3| 7| 6| |
DAY ON TEST | 0| 7| 1| 3| 3| 3| 8| 2| 1| 2| 0| 3| 0| 3| 9| 3| 3| 3| 3| 6| 3| 0| 7| 3| 2| |
| 9| 8| 8| 5| 4| 1| 3| 1| 0| 1| 6| 9| 8| 4| 4| 4| 4| 8| 4| 8| 4| 4| 2| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1250 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Metaplasia, Osseous | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 1| 6 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 5 1.2|
Thrombosis | | 1 |
Nares, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cataract | 2 2 3 4 3 3 3 3 3 2 3 3 2 3 3 2 3 3 3 4 | 45 2.7|
Degeneration | 3 | 2 3.5|
Hemorrhage | 3 | 3 2.7|
Cornea, Mineralization | 1 1 | 3 1.0|
Retina, Atrophy | 4 3 1 3 2 3 3 3 2 1 4 2| 21 2.6|
Retina, Degeneration | 1 1 1 | 13 1.2|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Embolus Bacterial | | 1 |
Hyperplasia, Atypical | | 1 1.0|
Nephropathy | 1 1 2 3 4 1 1 2 4 2 1 1 4 1 3 4 2 3 2 2 1 1 3 1| 47 2.0|
Pelvis, Dilatation | 3 | 1 3.0|
Renal Tubule, Degeneration | 1 2 3 3 2 1 2 2 1 2 1 3 2 2 3 1 2 1 3 1 1 1 1| 46 2.0|
Renal Tubule, Hyperplasia | 2 2 1 1 1 1 | 12 1.8|
Renal Tubule, Hyperplasia, Oncocytic | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 6| 7| 7| 6| 6| 5| 7|
DAY ON TEST | 3| 3| 9| 5| 3| 3| 2| 0| 0| 0| 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 1| 7| 9| 8| 3|
| 3| 3| 0| 9| 2| 3| 1| 9| 7| 9| 3| 3| 4| 3| 3| 3| 6| 7| 5| 6| 5| 7| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 1 1 2 3 3 2 2 2 1 2 2 |
Eosinophilic Focus | X X X |
Fatty Change | 3 3 1 3 |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X X X |
Regeneration | 3 2 |
Bile Duct, Hyperplasia | 2 2 2 2 4 2 3 2 3 1 4 1 3 1 2 2 3 4 1 2 2 1|
Centrilobular, Necrosis | 2 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + +|
Inflammation, Suppurative | 3 3 |
Fat, Hemorrhage | |
Fat, Necrosis | 2 2 3 3 3 2 2 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Acinus, Atrophy | 3 3 2 3 4 2 2 3 1 2 1 3 2 2 1 2 |
Duct, Concretion | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 |
Diverticulum | 2 |
Infiltration Cellular, Mast Cell | 1 |
Mineralization | 3 |
Necrosis | 2 4 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 |
Necrosis | 3 3 2 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 6| 7| 7| 6| 6| 5| 7|
DAY ON TEST | 3| 3| 9| 5| 3| 3| 2| 0| 0| 0| 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 1| 7| 9| 8| 3|
| 3| 3| 0| 9| 2| 3| 1| 9| 7| 9| 3| 3| 4| 3| 3| 3| 6| 7| 5| 6| 5| 7| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mineralization | 4 |
Aorta, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 3 2 2 2 2 2 3 3 2 1 2 2 2 2 2 2 1 2|
Mineralization | 3 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 1 2 1 2 2 2 |
Hypertrophy | 2 1|
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 2 2 1 2 2 1 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 3 1 3 1 1 1 2 1 1|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 3 1 1 3 3|
Inflammation, Granulomatous | |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4|
Interstitial Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 6| 7| 7| 6| 6| 5| 7|
DAY ON TEST | 3| 3| 9| 5| 3| 3| 2| 0| 0| 0| 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 1| 7| 9| 8| 3|
| 3| 3| 0| 9| 2| 3| 1| 9| 7| 9| 3| 3| 4| 3| 3| 3| 6| 7| 5| 6| 5| 7| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M M + M + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X X|
Fibrosis | 4 3 2 2 3 2|
Capsule, Fibrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + M + + + M + M + + M M M M + + + M + + +|
Galactocele | X |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Hyperkeratosis | |
Inflammation, Chronic Active | 2 3 3 3 |
Prepuce, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X |
Cranium, Fibrous Osteodystrophy | X |
Femur, Fibrous Osteodystrophy | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 2 1 |
Metaplasia, Squamous | 1 |
Mineralization | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 6| 7| 7| 6| 6| 5| 7|
DAY ON TEST | 3| 3| 9| 5| 3| 3| 2| 0| 0| 0| 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 1| 7| 9| 8| 3|
| 3| 3| 0| 9| 2| 3| 1| 9| 7| 9| 3| 3| 4| 3| 3| 3| 6| 7| 5| 6| 5| 7| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
Mineralization | 3 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
Thrombosis | X |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 3 |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 2 1 |
Cornea, Mineralization | 1 |
Retina, Atrophy | 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 2 1 2 2 3 4 4 2 2 3 2 2 2 4 3 3 2 1 4 4 3 3 1 1|
Renal Tubule, Degeneration | |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 6| 7| 7| 6| 5| 5| 7| 3| 5| 6| 4| 7| 5| |
DAY ON TEST | 5| 3| 3| 0| 0| 8| 0| 3| 3| 7| 3| 9| 2| 3| 0| 6| 9| 2| 3| 7| 5| 4| 8| 3| 9| |
| 5| 3| 3| 1| 2| 6| 8| 3| 3| 9| 3| 1| 4| 3| 5| 4| 4| 5| 3| 1| 9| 9| 9| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 3.0|
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X | 22 |
Clear Cell Focus | X X X X X | 7 |
Degeneration, Cystic | 1 2 2 3 2 1 | 17 1.9|
Eosinophilic Focus | | 3 |
Fatty Change | 2 | 5 2.4|
Hepatodiaphragmatic Nodule | | 2 |
Mixed Cell Focus | X X | 5 |
Regeneration | 2 | 3 2.3|
Bile Duct, Hyperplasia | 2 1 3 3 3 1 1 2 3 1 2 1 2 3 3 1 2 1 2 1 1 2| 44 2.0|
Centrilobular, Necrosis | 2 | 3 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 15 |
Inflammation, Suppurative | | 2 3.0|
Fat, Hemorrhage | 1 | 1 1.0|
Fat, Necrosis | 2 2 2 | 11 2.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 3 2.0|
Acinus, Atrophy | 3 2 2 2 1 2 1 4 1 2 2 2 1 2 1 1 | 32 2.0|
Duct, Concretion | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 2 2.0|
Diverticulum | 2 | 2 2.0|
Infiltration Cellular, Mast Cell | | 1 1.0|
Mineralization | | 1 3.0|
Necrosis | 1 1 | 6 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 6| 7| 7| 6| 5| 5| 7| 3| 5| 6| 4| 7| 5| |
DAY ON TEST | 5| 3| 3| 0| 0| 8| 0| 3| 3| 7| 3| 9| 2| 3| 0| 6| 9| 2| 3| 7| 5| 4| 8| 3| 9| |
| 5| 3| 3| 1| 2| 6| 8| 3| 3| 9| 3| 1| 4| 3| 5| 4| 4| 5| 3| 1| 9| 9| 9| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 4.0|
Necrosis | 2 1 | 5 2.2|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + + | 2 |
Dysplasia | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Mineralization | | 1 4.0|
Aorta, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 2 2 3 1 3 1 2 1 3 1 2 1 1 1 1 2 2 2 3 1| 46 1.8|
Mineralization | | 1 3.0|
Atrium, Thrombosis | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 1 2 2 1| 16 1.6|
Hypertrophy | 2 3 | 4 2.0|
Vacuolization Cytoplasmic | 3 | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 4 1 2 2 2 1 1| 21 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 1 2 1 2 1 1 1 | 22 1.3|
Follicular Cell, Hyperplasia | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 2 2 | 10 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 6| 7| 7| 6| 5| 5| 7| 3| 5| 6| 4| 7| 5| |
DAY ON TEST | 5| 3| 3| 0| 0| 8| 0| 3| 3| 7| 3| 9| 2| 3| 0| 6| 9| 2| 3| 7| 5| 4| 8| 3| 9| |
| 5| 3| 3| 1| 2| 6| 8| 3| 3| 9| 3| 1| 4| 3| 5| 4| 4| 5| 3| 1| 9| 9| 9| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Granulomatous | 4 | 1 4.0|
Duct, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 2 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 3.5|
Interstitial Cell, Hyperplasia | 1 2 1 1 1 1 | 8 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + +| 11 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Plasma Cell | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Hemorrhage | 2 | 3 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | | 2 |
Fibrosis | 3 2 2 | 9 2.6|
Capsule, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M + + + + + + + + + + + M + + M M + M M + M +| 33 |
Galactocele | | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Fibrosis | | 1 4.0|
Hyperkeratosis | 3 | 1 3.0|
Inflammation, Chronic Active | 2 1 2 2 3 | 9 2.3|
Prepuce, Edema | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 6| 7| 7| 6| 5| 5| 7| 3| 5| 6| 4| 7| 5| |
DAY ON TEST | 5| 3| 3| 0| 0| 8| 0| 3| 3| 7| 3| 9| 2| 3| 0| 6| 9| 2| 3| 7| 5| 4| 8| 3| 9| |
| 5| 3| 3| 1| 2| 6| 8| 3| 3| 9| 3| 1| 4| 3| 5| 4| 4| 5| 3| 1| 9| 9| 9| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Hyperostosis | | 1 |
Cranium, Fibrous Osteodystrophy | | 1 |
Femur, Fibrous Osteodystrophy | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X | 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 1 | 10 1.1|
Metaplasia, Squamous | | 1 1.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 36 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 1 1 1 | 9 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | | 1 3.0|
Thrombosis | X | 1 |
Alveolar Epithelium, Hyperplasia | 1 2 | 5 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 2 2 | 5 2.0|
Thrombosis | X | 2 |
Respiratory Epithelium, Hyperplasia | 1 | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Squamous | | 1 3.0|
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + +| 45 |
Cataract | 1 | 3 1.3|
Cornea, Mineralization | | 1 1.0|
Retina, Atrophy | 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 2 3 4 2 1 4 3 3 2 1 1 1 2 2 3 1 1 3 2 2 1 3 1| 49 2.3|
Renal Tubule, Degeneration | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 6| 7| 7| 6| 5| 5| 7| 3| 5| 6| 4| 7| 5| |
DAY ON TEST | 5| 3| 3| 0| 0| 8| 0| 3| 3| 7| 3| 9| 2| 3| 0| 6| 9| 2| 3| 7| 5| 4| 8| 3| 9| |
| 5| 3| 3| 1| 2| 6| 8| 3| 3| 9| 3| 1| 4| 3| 5| 4| 4| 5| 3| 1| 9| 9| 9| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + I + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 5| 5| 5| 6| 6| 7| 6| 6| 6| 5| 7| 5| 5| 6| 5| 4| 6| 5| 7| 4|
DAY ON TEST | 3| 5| 3| 3| 2| 5| 9| 9| 2| 8| 1| 6| 9| 5| 2| 1| 8| 0| 0| 5| 9| 8| 9| 3| 5|
| 3| 3| 3| 3| 7| 5| 4| 4| 1| 1| 6| 4| 8| 9| 9| 6| 1| 9| 4| 5| 4| 6| 4| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
156 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | X X X X X |
Degeneration, Cystic | 1 2 3 1 3 1 2 2 3 2 3 2 2 2 1 2 2 2 |
Eosinophilic Focus | X X X X X X X X X |
Fatty Change | 2 3 |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X X X |
Regeneration | 3 4 |
Bile Duct, Hyperplasia | 3 3 3 3 3 2 3 3 3 2 1 3 2 3 2 3 2 1 1 1 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 2 2 2 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Hyperplasia | |
Acinus, Atrophy | 2 1 2 2 3 2 2 3 2 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Diverticulum | |
Necrosis | 1 1 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis | 3 2 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 5| 5| 5| 6| 6| 7| 6| 6| 6| 5| 7| 5| 5| 6| 5| 4| 6| 5| 7| 4|
DAY ON TEST | 3| 5| 3| 3| 2| 5| 9| 9| 2| 8| 1| 6| 9| 5| 2| 1| 8| 0| 0| 5| 9| 8| 9| 3| 5|
| 3| 3| 3| 3| 7| 5| 4| 4| 1| 1| 6| 4| 8| 9| 9| 6| 1| 9| 4| 5| 4| 6| 4| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
156 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 3 2 3 2 2 2 3 2 2 3 3 2 3 1 2 3 1 1 3 3 1 1|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 4 2 2 3 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + I + + + + + + +|
Thrombosis | X |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 2 2 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 3 3 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Interstitial Cell, Hyperplasia | 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 5| 5| 5| 6| 6| 7| 6| 6| 6| 5| 7| 5| 5| 6| 5| 4| 6| 5| 7| 4|
DAY ON TEST | 3| 5| 3| 3| 2| 5| 9| 9| 2| 8| 1| 6| 9| 5| 2| 1| 8| 0| 0| 5| 9| 8| 9| 3| 5|
| 3| 3| 3| 3| 7| 5| 4| 4| 1| 1| 6| 4| 8| 9| 9| 6| 1| 9| 4| 5| 4| 6| 4| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
156 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Developmental Malformation | X X |
Fibrosis | 2 3 2 3 |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Lipocyte | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + M + + + + + M + + M + + M M + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 |
Inflammation, Chronic Active | 2 3 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 |
Metaplasia, Squamous | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1|
Mineralization | |
Alveolar Epithelium, Hyperplasia | 1 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 5| 5| 5| 6| 6| 7| 6| 6| 6| 5| 7| 5| 5| 6| 5| 4| 6| 5| 7| 4|
DAY ON TEST | 3| 5| 3| 3| 2| 5| 9| 9| 2| 8| 1| 6| 9| 5| 2| 1| 8| 0| 0| 5| 9| 8| 9| 3| 5|
| 3| 3| 3| 3| 7| 5| 4| 4| 1| 1| 6| 4| 8| 9| 9| 6| 1| 9| 4| 5| 4| 6| 4| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
156 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Degeneration | 3 |
Cornea, Inflammation, Chronic Active | |
Retina, Atrophy | 1 1 |
__________________________________________________________________________|
Harderian Gland | |
Hypertrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 |
Mineralization | |
Nephropathy | 2 2 2 3 2 1 1 2 1 2 3 2 3 3 1 2 1 1 2 1 1 4 1 3 1|
Renal Tubule, Degeneration | 2 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 7| 6| 3| 3| 8| 0| 5| 1| 1| 9| 3| 1| 3| 0| 3| 0| 5| 3| 0| 3| 9| 1| 3| |
| 3| 3| 0| 4| 3| 3| 9| 0| 2| 1| 6| 1| 3| 2| 3| 5| 0| 2| 1| 3| 0| 3| 2| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
156 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 1| 2| 3| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 | 1 3.0|
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1| 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 1 3| 3 2.7|
Basophilic Focus | X X X X X X X X X X X| 19 |
Clear Cell Focus | X X X | 8 |
Degeneration, Cystic | 2 1 3 2 3 2 1 3 3 1 1 2 1 1 1 4 1 2 2 3 2| 39 2.0|
Eosinophilic Focus | X X X X X X X X X| 18 |
Fatty Change | 1 | 3 2.0|
Hepatodiaphragmatic Nodule | | 2 |
Mixed Cell Focus | X X | 5 |
Regeneration | 2 2 | 4 2.8|
Bile Duct, Hyperplasia | 3 2 2 4 1 3 3 3 3 3 1 3 2 2 1 3 2 3 3 2 3 1| 43 2.3|
Centrilobular, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 11 |
Fat, Necrosis | 2 1 2 2 2 | 11 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X | 4 |
Hyperplasia | 2 | 1 2.0|
Acinus, Atrophy | 2 2 2 3 2 1 3 1 1 1 2 4 2 1 | 25 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 | 1 3.0|
Diverticulum | 1| 1 1.0|
Necrosis | 2 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 3 2 | 3 2.3|
Necrosis | 2 | 3 2.3|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 7| 6| 3| 3| 8| 0| 5| 1| 1| 9| 3| 1| 3| 0| 3| 0| 5| 3| 0| 3| 9| 1| 3| |
| 3| 3| 0| 4| 3| 3| 9| 0| 2| 1| 6| 1| 3| 2| 3| 5| 0| 2| 1| 3| 0| 3| 2| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
156 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 1| 2| 3| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + | 2 |
Dysplasia | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 2 2 2 2 1 2 2 2 3 2 2 2 1 2 2 1 2 2| 44 2.0|
Atrium, Thrombosis | X X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 1 1 2 1 1 1 | 13 1.4|
Hypertrophy | 2 3 2 | 4 2.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3 2 2 2 1 2 1 2| 21 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1| 3 1.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Thrombosis | | 1 |
Pars Distalis, Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 3 2 1 2 1 1 1 2 3 1 2 1 2| 24 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 2 3 2 2 | 8 2.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4| 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4| 2 3.5|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 | 10 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 7| 6| 3| 3| 8| 0| 5| 1| 1| 9| 3| 1| 3| 0| 3| 0| 5| 3| 0| 3| 9| 1| 3| |
| 3| 3| 0| 4| 3| 3| 9| 0| 2| 1| 6| 1| 3| 2| 3| 5| 0| 2| 1| 3| 0| 3| 2| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
156 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 1| 2| 3| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 1 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 4.0|
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + M M + + + + + + + + + M + + + +| 47 |
Hemorrhage | 1 | 1 1.0|
Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Developmental Malformation | X | 3 |
Fibrosis | 2 2 3 3 4 4 4 2 3 1| 14 2.7|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Infiltration Cellular, Lipocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + M + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M + + M + + + + M + + + + + + M + M M + M + +| 36 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 4.0|
Inflammation, Chronic Active | | 4 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | X | 1 |
Cranium, Fibrous Osteodystrophy | X | 1 |
Femur, Fibrous Osteodystrophy | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X | 11 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 7| 6| 3| 3| 8| 0| 5| 1| 1| 9| 3| 1| 3| 0| 3| 0| 5| 3| 0| 3| 9| 1| 3| |
| 3| 3| 0| 4| 3| 3| 9| 0| 2| 1| 6| 1| 3| 2| 3| 5| 0| 2| 1| 3| 0| 3| 2| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
156 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 1| 2| 3| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 | 9 1.0|
Metaplasia, Squamous | 1 | 1 1.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 38 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 2 1 | 5 1.2|
Mineralization | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 4 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + M + + + + + + +| 42 |
Degeneration | | 1 3.0|
Cornea, Inflammation, Chronic Active | 1| 1 1.0|
Retina, Atrophy | | 2 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Hypertrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 4 | 3 2.3|
Mineralization | 2 | 1 2.0|
Nephropathy | 3 1 1 2 2 1 1 1 3 1 3 1 2 1 2 2 4 3 1 2 3 3 3 1 3| 50 1.9|
Renal Tubule, Degeneration | 1 1 1 1 1 2 1 1 1 1| 20 1.1|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 3| 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 5| 7| 6| 6| 6| 6| 5| 4| 7| 5| 7| 7| 7| 6| 6| 7| 6| 6| 7|
DAY ON TEST | 1| 3| 3| 7| 1| 2| 7| 3| 8| 1| 7| 3| 7| 1| 3| 8| 3| 3| 3| 6| 6| 2| 3| 2| 3|
| 7| 3| 3| 7| 7| 6| 6| 3| 8| 6| 4| 2| 5| 3| 3| 1| 3| 3| 3| 3| 4| 9| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|
| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X|
Degeneration, Cystic | 3 2 3 3 3 2 2 1 2 1 4 2 3 2 2 1 3 3 2 2|
Eosinophilic Focus | X X X X X X X X X X X X|
Fatty Change | 2 1 |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X X X X X X |
Necrosis, Focal | |
Regeneration | |
Thrombosis | |
Bile Duct, Hyperplasia | 3 2 2 3 2 2 1 2 3 3 3 3 1 4 2 2 1 1 2 2 2 2 3 2|
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + + + +|
Fat, Hemorrhage | 2 |
Fat, Necrosis | 3 2 2 2 3 3 2 1|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Hyperplasia | 3 2 |
Acinus, Atrophy | 2 2 2 1 1 2 1 1 2 1 1 3 1 1 2 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 4 |
Diverticulum | 2 |
Infiltration Cellular, Mast Cell | 2 |
Mineralization | |
Necrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 2 |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 5| 7| 6| 6| 6| 6| 5| 4| 7| 5| 7| 7| 7| 6| 6| 7| 6| 6| 7|
DAY ON TEST | 1| 3| 3| 7| 1| 2| 7| 3| 8| 1| 7| 3| 7| 1| 3| 8| 3| 3| 3| 6| 6| 2| 3| 2| 3|
| 7| 3| 3| 7| 7| 6| 6| 3| 8| 6| 4| 2| 5| 3| 3| 1| 3| 3| 3| 3| 4| 9| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|
| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | |
Aorta, Mineralization | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 2 3 2 2 2 1 2 2 1 3 1 4 3 2 2 3 2 2|
Mineralization | |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 1 2 2 1 2 2|
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 3 2 1 2 1 2 2 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 3 2 1 2 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 1 2 3 1 3 3 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Mineralization | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3|
Interstitial Cell, Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 5| 7| 6| 6| 6| 6| 5| 4| 7| 5| 7| 7| 7| 6| 6| 7| 6| 6| 7|
DAY ON TEST | 1| 3| 3| 7| 1| 2| 7| 3| 8| 1| 7| 3| 7| 1| 3| 8| 3| 3| 3| 6| 6| 2| 3| 2| 3|
| 7| 3| 3| 7| 7| 6| 6| 3| 8| 6| 4| 2| 5| 3| 3| 1| 3| 3| 3| 3| 4| 9| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|
| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + M + M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + + + + + + + + + + + M + + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | 1 2 2 2 3 4 2 3|
Hematopoietic Cell Proliferation | |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + M + + + + M + + + + + M + + M + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Cranium, Fibrous Osteodystrophy | X |
Femur, Fibrous Osteodystrophy | X |
Sternum, Developmental Malformation | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 |
Metaplasia, Squamous | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 |
Mineralization | 2 |
Alveolar Epithelium, Hyperplasia | 4 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 5| 7| 6| 6| 6| 6| 5| 4| 7| 5| 7| 7| 7| 6| 6| 7| 6| 6| 7|
DAY ON TEST | 1| 3| 3| 7| 1| 2| 7| 3| 8| 1| 7| 3| 7| 1| 3| 8| 3| 3| 3| 6| 6| 2| 3| 2| 3|
| 7| 3| 3| 7| 7| 6| 6| 3| 8| 6| 4| 2| 5| 3| 3| 1| 3| 3| 3| 3| 4| 9| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|
| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 1 2 2 |
Degeneration | 3 3 |
Cornea, Mineralization | 1 |
Retina, Atrophy | 1 1 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Nephropathy | 2 2 3 3 2 4 3 4 4 1 2 2 3 1 2 1 3 3 4 2 3 4 2 2 3|
Pelvis, Dilatation | 2 |
Renal Tubule, Degeneration | 3 2 3 3 2 3 2 3 2 2 2 3 2 1 2 2 2 1 2 2 3 3 2 1 2|
Renal Tubule, Hyperplasia | |
Renal Tubule, Hyperplasia, Oncocytic | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 6| 6| 5| 6| 5| 7| 6| 6| 7| 6| 6| 5| 7| 7| 7| 6| 6| 7| 6| |
DAY ON TEST | 3| 9| 6| 3| 3| 3| 9| 5| 3| 1| 4| 3| 3| 2| 3| 3| 7| 5| 3| 3| 3| 6| 3| 2| 1| |
| 3| 3| 4| 3| 3| 3| 1| 8| 8| 4| 7| 3| 2| 7| 3| 5| 4| 9| 3| 3| 3| 4| 8| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
312 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X| 33 |
Clear Cell Focus | X X X X | 11 |
Degeneration, Cystic | 4 3 3 4 2 1 3 2 3 1 4 2 2 3 2| 35 2.4|
Eosinophilic Focus | X X X X X X X X X X | 22 |
Fatty Change | 2 2 | 4 1.8|
Hepatodiaphragmatic Nodule | X X | 3 |
Mixed Cell Focus | X X X X X X X X X X | 16 |
Necrosis, Focal | 3 | 1 3.0|
Regeneration | 3 | 1 3.0|
Thrombosis | X | 1 |
Bile Duct, Hyperplasia | 3 2 3 4 2 2 3 3 3 2 1 2 3 4 2 1 2 3 2 2| 44 2.3|
Centrilobular, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + +| 18 |
Fat, Hemorrhage | 2 2 | 3 2.0|
Fat, Necrosis | 2 2 3 2 2 3 2 3| 16 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Hyperplasia | 3 | 3 2.7|
Acinus, Atrophy | 1 2 2 2 2 2 3 1 2 2 2 2 2 3 2| 31 1.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 2 3.0|
Diverticulum | 2 | 2 2.0|
Infiltration Cellular, Mast Cell | | 1 2.0|
Mineralization | 3 3 | 2 3.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 3 | 4 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 6| 6| 5| 6| 5| 7| 6| 6| 7| 6| 6| 5| 7| 7| 7| 6| 6| 7| 6| |
DAY ON TEST | 3| 9| 6| 3| 3| 3| 9| 5| 3| 1| 4| 3| 3| 2| 3| 3| 7| 5| 3| 3| 3| 6| 3| 2| 1| |
| 3| 3| 4| 3| 3| 3| 1| 8| 8| 4| 7| 3| 2| 7| 3| 5| 4| 9| 3| 3| 3| 4| 8| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
312 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Dysplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 3 |
Mineralization | 3 2 | 2 2.5|
Aorta, Mineralization | 4 4 | 3 3.3|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 1 2 2 3 3 2 2 1 2 3 2 2 2 2 3 3 2 2 3 2 1| 43 2.2|
Mineralization | 2 2 | 2 2.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 1 1 2 2 1 2 3 | 21 1.5|
Hypertrophy | 3 1 3 1| 5 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 2 3 2 2 2 2 2 2 2| 23 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 4 4 | 7 2.6|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 1 | 4 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 1 1 2 1 1 2 1 2 1 2 1 2 1 2 2 1 1| 35 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 1 3 3 2 | 10 2.2|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 6| 6| 5| 6| 5| 7| 6| 6| 7| 6| 6| 5| 7| 7| 7| 6| 6| 7| 6| |
DAY ON TEST | 3| 9| 6| 3| 3| 3| 9| 5| 3| 1| 4| 3| 3| 2| 3| 3| 7| 5| 3| 3| 3| 6| 3| 2| 1| |
| 3| 3| 4| 3| 3| 3| 1| 8| 8| 4| 7| 3| 2| 7| 3| 5| 4| 9| 3| 3| 3| 4| 8| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
312 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
Mineralization | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 3.0|
Interstitial Cell, Hyperplasia | 2 1 1 | 6 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + M + + + + + M + +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Plasma Cell | 4 2 2 | 5 2.6|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | X | 1 |
Fibrosis | 3 3 3 | 11 2.5|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Capsule, Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + M + + M + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + + + + + + + + + + + + M + + + + + M + +| 41 |
Galactocele | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic Active | 3 3 3 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | X | 1 |
Cranium, Fibrous Osteodystrophy | X X | 3 |
Femur, Fibrous Osteodystrophy | X X | 3 |
Sternum, Developmental Malformation | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 6| 6| 5| 6| 5| 7| 6| 6| 7| 6| 6| 5| 7| 7| 7| 6| 6| 7| 6| |
DAY ON TEST | 3| 9| 6| 3| 3| 3| 9| 5| 3| 1| 4| 3| 3| 2| 3| 3| 7| 5| 3| 3| 3| 6| 3| 2| 1| |
| 3| 3| 4| 3| 3| 3| 1| 8| 8| 4| 7| 3| 2| 7| 3| 5| 4| 9| 3| 3| 3| 4| 8| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
312 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X | 9 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 8 1.0|
Metaplasia, Squamous | 2 | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 | 36 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 3 1.0|
Mineralization | 4 3 | 3 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 2.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 4 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cataract | 2| 4 1.8|
Degeneration | 3 3 | 4 3.0|
Cornea, Mineralization | 1 | 2 1.0|
Retina, Atrophy | 2 1| 5 1.6|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 4 | 3 3.3|
Nephropathy | 4 2 2 3 3 4 3 1 1 1 2 3 4 3 3 2 3 3 4 4 3 4 4 3 2| 50 2.7|
Pelvis, Dilatation | | 1 2.0|
Renal Tubule, Degeneration | 2 2 2 2 3 3 3 2 1 2 1 1 4 3 2 2 2 2 3 3 3 3 4 3 2| 50 2.3|
Renal Tubule, Hyperplasia | 4 | 1 4.0|
Renal Tubule, Hyperplasia, Oncocytic | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 5| 5| 5| 6| 5| 5| 5| 6| 6| 5| 7| 6| 4| 6| 6| 5| 6| 6| 7| 6| 7| 6| 6| 6| 6|
DAY ON TEST | 9| 4| 8| 6| 5| 7| 2| 1| 3| 2| 2| 1| 5| 2| 3| 0| 9| 3| 3| 3| 3| 8| 8| 3| 1|
| 4| 4| 6| 3| 9| 1| 5| 7| 9| 3| 1| 7| 5| 1| 9| 9| 5| 0| 0| 2| 3| 8| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | 1 |
Peyer's Patch, Inflammation, | |
Granulomatous | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | X X X X X X X X X X X X|
Clear Cell Focus | |
Congestion | |
Cyst | |
Degeneration, Cystic | 2 2 2 2 2 2 2 2 3 2 2 2 3 1 2|
Eosinophilic Focus | X X X X X X X X|
Fatty Change | 1 2 |
Fibrosis | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | |
Mineralization | 2 |
Mixed Cell Focus | X X X X X X |
Bile Duct, Hyperplasia | 3 2 2 3 2 1 3 2 2 2 2 2 2 2 3 2 3 1 1 1|
__________________________________________________________________________|
Mesentery | + + + + + + + +|
Fat, Hemorrhage | |
Fat, Necrosis | 3 2 2 3 2 2 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Acinus, Atrophy | 3 1 3 2 1 1 1 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 1 2 |
Mineralization | 1 2 2 |
Necrosis | 2 2 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 3 2 3 2 2 2 3|
Necrosis | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 5| 5| 5| 6| 5| 5| 5| 6| 6| 5| 7| 6| 4| 6| 6| 5| 6| 6| 7| 6| 7| 6| 6| 6| 6|
DAY ON TEST | 9| 4| 8| 6| 5| 7| 2| 1| 3| 2| 2| 1| 5| 2| 3| 0| 9| 3| 3| 3| 3| 8| 8| 3| 1|
| 4| 4| 6| 3| 9| 1| 5| 7| 9| 3| 1| 7| 5| 1| 9| 9| 5| 0| 0| 2| 3| 8| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + +|
Mineralization | 3 4 |
Aorta, Mineralization | 4 4 1 3 1 2 3|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 3 1 1 1 2 1 1 2 2 1 3 2 3 2 3 3 2 2 2 3 2|
Mineralization | 2 1 3 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 1 1 1 1|
Hypertrophy | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 2 2 2 1 2 2 1 2 3 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 3 1 2 2 3 2 3 2 2 2 3 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 1 3 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 5| 5| 5| 6| 5| 5| 5| 6| 6| 5| 7| 6| 4| 6| 6| 5| 6| 6| 7| 6| 7| 6| 6| 6| 6|
DAY ON TEST | 9| 4| 8| 6| 5| 7| 2| 1| 3| 2| 2| 1| 5| 2| 3| 0| 9| 3| 3| 3| 3| 8| 8| 3| 1|
| 4| 4| 6| 3| 9| 1| 5| 7| 9| 3| 1| 7| 5| 1| 9| 9| 5| 0| 0| 2| 3| 8| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Iliac, Pigmentation | 2 |
Lumbar, Hemorrhage | 1 |
Pancreatic, Edema | |
Renal, Edema | 2 |
Renal, Hemorrhage | |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + + M + + + + + + + + + + + M|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + M + + + + M + + + + +|
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + M M + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X X |
Fibrosis | 3 3 2 2 3 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + + + M + + + + + M + + M + M + + + + M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Hyperkeratosis | 3 |
Inflammation, Chronic Active | 3 3 3 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X X X X X X X X X|
Femur, Fibrous Osteodystrophy | X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 1 1 1 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
_____________________________________________________________________________________________________________________
| 5| 5| 5| 6| 5| 5| 5| 6| 6| 5| 7| 6| 4| 6| 6| 5| 6| 6| 7| 6| 7| 6| 6| 6| 6|
DAY ON TEST | 9| 4| 8| 6| 5| 7| 2| 1| 3| 2| 2| 1| 5| 2| 3| 0| 9| 3| 3| 3| 3| 8| 8| 3| 1|
| 4| 4| 6| 3| 9| 1| 5| 7| 9| 3| 1| 7| 5| 1| 9| 9| 5| 0| 0| 2| 3| 8| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | 1 1 1 1 |
Mineralization | 3 2 4 2 4|
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 2 2 1 |
Thrombosis | X |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
Olfactory Epithelium, Degeneration | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | |
Mineralization | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + +|
Cornea, Inflammation, Chronic Active | 2 2 2 1|
Cornea, Mineralization | 2 3 2 |
Retina, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Mineralization | 3 3 3 |
Nephropathy | 2 3 4 4 3 3 2 4 4 4 4 3 2 4 4 4 4 4 4 4 4 4 4 4 4|
Renal Tubule, Degeneration | 4 4 4 3 4 3 4 3 4 3 4 3 3 3 3 4 3 4 3 3 4 4 4 4|
Renal Tubule, Hyperplasia | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 3| 6| 6| 5| 4| 6| 6| 6| 6| 7| 6| 5| 5| |
DAY ON TEST | 3| 7| 7| 9| 3| 1| 9| 0| 9| 1| 1| 6| 6| 5| 0| 7| 8| 1| 2| 0| 6| 0| 2| 5| 8| |
| 1| 2| 4| 0| 2| 2| 1| 8| 3| 0| 1| 8| 1| 2| 4| 2| 1| 7| 6| 3| 3| 2| 6| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 8| 9| 0| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 2.0|
Parasite Metazoan | X X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 1 1.0|
Peyer's Patch, Inflammation, | | |
Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 3 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X| 29 |
Clear Cell Focus | X X X| 3 |
Congestion | 3 | 1 3.0|
Cyst | X | 1 |
Degeneration, Cystic | 2 2 2 3 2 4 2 2 2 2 2 4 2 2 1 2 2| 32 2.2|
Eosinophilic Focus | X X X X X X X X X X X | 19 |
Fatty Change | 1 1 1 | 5 1.2|
Fibrosis | 3 | 1 3.0|
Hepatodiaphragmatic Nodule | X X X| 4 |
Hyperplasia | 3 | 1 3.0|
Mineralization | | 1 2.0|
Mixed Cell Focus | X X X X X X X | 13 |
Bile Duct, Hyperplasia | 2 2 2 2 2 1 4 1 1 1 2 2 1 1 1 2 2 2 2 3 2 1| 42 1.9|
__________________________________________________________________________|____________|
Mesentery | + + + + + +| 14 |
Fat, Hemorrhage | 2 | 1 2.0|
Fat, Necrosis | 3 3 2 2 2| 12 2.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 4 |
Acinus, Atrophy | 1 1 2 2 2 2 3 2 1 1 2| 20 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 | 5 1.8|
Mineralization | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 3| 6| 6| 5| 4| 6| 6| 6| 6| 7| 6| 5| 5| |
DAY ON TEST | 3| 7| 7| 9| 3| 1| 9| 0| 9| 1| 1| 6| 6| 5| 0| 7| 8| 1| 2| 0| 6| 0| 2| 5| 8| |
| 1| 2| 4| 0| 2| 2| 1| 8| 3| 0| 1| 8| 1| 2| 4| 2| 1| 7| 6| 3| 3| 2| 6| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 8| 9| 0| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis | 4 2 | 6 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 3 4 3 3 | 13 2.7|
Necrosis | 2 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Dysplasia | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 12 |
Mineralization | 4 | 3 3.7|
Aorta, Mineralization | 2 1 3 3 2 | 12 2.4|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 3 2 2 3 2 1 3 2 2 1 1 2 2 3 3 1 2 3 1 2 1| 48 2.0|
Mineralization | 2 | 4 2.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 1 1 3 1 2 1 | 17 1.4|
Hypertrophy | 1 1| 4 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 2 1 2 2 2 1 2 2 3 2 | 26 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 2 2 2 3 2 2 2 1 2 | 25 2.1|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 2 1 1 2 2 | 8 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 2 1 1 1 3 1 1 1 1 1 | 20 1.2|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 3| 6| 6| 5| 4| 6| 6| 6| 6| 7| 6| 5| 5| |
DAY ON TEST | 3| 7| 7| 9| 3| 1| 9| 0| 9| 1| 1| 6| 6| 5| 0| 7| 8| 1| 2| 0| 6| 0| 2| 5| 8| |
| 1| 2| 4| 0| 2| 2| 1| 8| 3| 0| 1| 8| 1| 2| 4| 2| 1| 7| 6| 3| 3| 2| 6| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 8| 9| 0| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 4 2 2 1 3 2 2| 14 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 2 1 1 1 1 1| 8 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 17 |
Iliac, Pigmentation | | 1 2.0|
Lumbar, Hemorrhage | 2 | 2 1.5|
Pancreatic, Edema | 2 | 1 2.0|
Renal, Edema | 2 | 2 2.0|
Renal, Hemorrhage | 1 | 1 1.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| 46 |
Infiltration Cellular, Plasma Cell | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M + + + + + + + + + + + + M + + + + + +| 46 |
Hemorrhage | 3 1 | 3 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | X X | 4 |
Fibrosis | 3 | 6 2.7|
Hematopoietic Cell Proliferation | 3 1 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M M + + + + + + + + + + + M + + M + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + M M + + + M M M M + + + M + + + +| 34 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 4.0|
Hyperkeratosis | | 1 3.0|
Inflammation, Chronic Active | 2 | 4 2.8|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 3| 6| 6| 5| 4| 6| 6| 6| 6| 7| 6| 5| 5| |
DAY ON TEST | 3| 7| 7| 9| 3| 1| 9| 0| 9| 1| 1| 6| 6| 5| 0| 7| 8| 1| 2| 0| 6| 0| 2| 5| 8| |
| 1| 2| 4| 0| 2| 2| 1| 8| 3| 0| 1| 8| 1| 2| 4| 2| 1| 7| 6| 3| 3| 2| 6| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 8| 9| 0| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | X X X X X X X X | 17 |
Femur, Fibrous Osteodystrophy | X X X X X X X X | 19 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X| 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 1 1 | 12 1.1|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 33 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 | 1 4.0|
Hemorrhage | 1 1 1 1 | 8 1.0|
Mineralization | 3 3 3 3 1 2 2 | 12 2.7|
Thrombosis | X | 1 |
Alveolar Epithelium, Hyperplasia | 3 4 | 3 3.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 2 | 7 1.6|
Thrombosis | | 1 |
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 2.0|
Olfactory Epithelium, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Squamous | 1 | 1 1.0|
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + +| 42 |
Cornea, Inflammation, Chronic Active | | 4 1.8|
Cornea, Mineralization | 2 2 1 2 | 7 2.0|
Retina, Atrophy | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | X | 1 |
Mineralization | 2 | 4 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05132-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAFLUOROETHYLENE (TFE) Date: 08/11/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:32:59
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 3| 6| 6| 5| 4| 6| 6| 6| 6| 7| 6| 5| 5| |
DAY ON TEST | 3| 7| 7| 9| 3| 1| 9| 0| 9| 1| 1| 6| 6| 5| 0| 7| 8| 1| 2| 0| 6| 0| 2| 5| 8| |
| 1| 2| 4| 0| 2| 2| 1| 8| 3| 0| 1| 8| 1| 2| 4| 2| 1| 7| 6| 3| 3| 2| 6| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 8| 9| 0| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 2 2 4 4 4 4 4 3 3 3 4 4 1 4 4 4 1 4 4 4 4 4 4 3 4| 50 3.5|
Renal Tubule, Degeneration | 4 4 4 4 4 3 3 4 4 4 3 3 3 3 3 3 4 4 3 4 4 4 4 4 4| 49 3.6|
Renal Tubule, Hyperplasia | 1 1 3 1 | 6 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
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---------- END OF REPORT ----------
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