TDMS Study 05100-04 Pathology Tables
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:05
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1330-78-5
Lock Date: 12/13/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 95 95 95 95
Scheduled Sacrifice 45 45 45 44
Early Deaths
Natural Death 5 7 2 3
Moribund Sacrifice 4 5 4 3
Survivors
Natural Death 1 1
Terminal Sacrifice 40 37 42 45
Missing 2
Animals Examined Microscopically 95 95 93 95
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (80) (80) (78) (80)
Inflammation 1 (1%)
Intestine Small, Duodenum (80) (80) (78) (79)
Ulcer, Chronic Active 1 (1%) 1 (1%)
Intestine Small, Jejunum (79) (80) (78) (80)
Lymphoid Tissue, Hyperplasia 1 (1%) 1 (1%) 1 (1%)
Lymphoid Tissue, Ulcer, Chronic Active 1 (1%)
Intestine Small, Ileum (79) (80) (77) (80)
Amyloid Deposition 1 (1%) 1 (1%)
Lymphoid Tissue, Hyperplasia 1 (1%)
Liver (80) (80) (78) (80)
Angiectasis 1 (1%) 1 (1%)
Basophilic Focus 4 (5%) 3 (4%) 1 (1%)
Clear Cell Focus 4 (5%)
Eosinophilic Focus 8 (10%) 4 (5%) 5 (6%) 7 (9%)
Fatty Change 3 (4%) 1 (1%) 1 (1%)
Hematopoietic Cell Proliferation 1 (1%) 1 (1%)
Infarct 1 (1%)
Inflammation, Chronic Active 1 (1%) 1 (1%) 1 (1%)
Mixed Cell Focus 1 (1%) 2 (3%) 2 (3%)
Necrosis 3 (4%) 2 (3%) 2 (3%) 2 (3%)
Pigmentation, Ceroid 1 (1%) 2 (3%)
Pigmentation, Hemosiderin 1 (1%)
Bile Duct, Cyst 1 (1%)
Centrilobular, Degeneration 1 (1%)
Serosa, Inflammation 1 (1%)
Mesentery (6) (5) (6) (3)
Hemorrhage 1 (20%)
Inflammation, Chronic Active 1 (20%) 1 (17%) 1 (33%)
Inflammation, Suppurative 1 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Necrosis 4 (67%) 1 (20%) 5 (83%) 2 (67%)
Pancreas (80) (80) (78) (80)
Atrophy 4 (5%) 6 (8%) 4 (5%) 1 (1%)
Hyperplasia 1 (1%)
Duct, Cyst 1 (1%) 2 (3%) 1 (1%)
Salivary Glands (79) (80) (78) (80)
Inflammation, Chronic Active 1 (1%)
Duct, Hyperplasia 1 (1%)
Stomach, Forestomach (80) (80) (78) (80)
Hyperplasia 2 (3%) 1 (1%) 1 (1%)
Stomach, Glandular (80) (80) (78) (80)
Cyst 1 (1%)
Erosion 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Mineralization 1 (100%)
Polyarteritis 1 (100%)
Heart (80) (80) (78) (80)
Degeneration 1 (1%)
Infarct 1 (1%)
Inflammation, Chronic Active 1 (1%) 1 (1%) 1 (1%)
Mineralization 1 (1%)
Artery, Inflammation, Chronic Active 1 (1%)
Atrium, Thrombosis 1 (1%)
Pericardium, Inflammation, Chronic Active 2 (3%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (80) (79) (78) (80)
Accessory Adrenal Cortical Nodule 5 (6%) 6 (8%) 4 (5%) 1 (1%)
Hematopoietic Cell Proliferation 1 (1%)
Hyperplasia 4 (5%) 1 (1%) 7 (9%) 2 (3%)
Pigmentation, Ceroid 68 (85%) 69 (87%) 67 (86%) 71 (89%)
Subcapsular, Hyperplasia 80 (100%) 79 (100%) 74 (95%) 80 (100%)
Adrenal Medulla (80) (79) (78) (78)
Hyperplasia 1 (1%) 3 (4%) 1 (1%) 4 (5%)
Islets, Pancreatic (80) (80) (78) (80)
Hyperplasia 2 (3%) 5 (6%) 2 (3%)
Parathyroid Gland (71) (67) (66) (67)
Cyst 1 (1%) 1 (1%)
Hyperplasia 1 (1%)
Pituitary Gland (76) (76) (76) (79)
Angiectasis 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Cyst 2 (3%) 1 (1%)
Pars Distalis, Hyperplasia 21 (28%) 23 (30%) 21 (28%) 19 (24%)
Pars Intermedia, Hyperplasia 1 (1%) 1 (1%)
Thyroid Gland (79) (80) (78) (80)
Inflammation 1 (1%) 1 (1%) 3 (4%)
Follicle, Cyst 3 (4%) 2 (3%) 4 (5%)
Follicular Cell, Hyperplasia 7 (9%) 9 (11%) 13 (17%) 15 (19%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (2) (1) (1) (1)
Duct, Dilatation 2 (100%) 1 (100%) 1 (100%) 1 (100%)
Ovary (78) (80) (77) (79)
Angiectasis 1 (1%) 1 (1%) 1 (1%)
Atrophy 5 (6%) 1 (1%) 2 (3%) 1 (1%)
Cyst 16 (21%) 13 (16%) 16 (21%) 22 (28%)
Hyperplasia, Cystic 1 (1%)
Inflammation, Suppurative 1 (1%)
Thrombosis 1 (1%)
Corpus Luteum, Hyperplasia 1 (1%) 1 (1%)
Periovarian Tissue, Inflammation,
Granulomatous 1 (1%)
Rete Ovarii, Hyperplasia 2 (3%)
Uterus (80) (80) (78) (80)
Angiectasis 1 (1%) 2 (3%) 2 (3%)
Hemorrhage 1 (1%)
Hyperplasia, Cystic 61 (76%) 53 (66%) 53 (68%) 57 (71%)
Inflammation, Suppurative 1 (1%)
Thrombosis 2 (3%)
Lymphatic, Angiectasis 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (80) (80) (78) (80)
Hyperplasia 10 (13%) 6 (8%) 5 (6%) 6 (8%)
Infarct 1 (1%)
Myelofibrosis 18 (23%) 23 (29%) 27 (35%) 26 (33%)
Lymph Node (3) (4) (3)
Mediastinal, Pigmentation, Hemosiderin 1 (33%)
Lymph Node, Mandibular (75) (77) (78) (76)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (1%) 3 (4%) 2 (3%)
Hyperplasia, Plasma Cell 1 (1%)
Lymph Node, Mesenteric (78) (75) (75) (78)
Cyst 1 (1%)
Hematopoietic Cell Proliferation 1 (1%)
Hyperplasia, Lymphoid 1 (1%) 3 (4%) 6 (8%)
Spleen (80) (80) (78) (80)
Depletion Lymphoid 2 (3%) 1 (1%) 1 (1%) 1 (1%)
Fibrosis 1 (1%)
Hematopoietic Cell Proliferation 23 (29%) 20 (25%) 18 (23%) 26 (33%)
Hyperplasia, Lymphoid 5 (6%) 7 (9%) 4 (5%) 8 (10%)
Thymus (75) (74) (77) (74)
Cyst 1 (1%) 1 (1%)
Depletion Lymphoid 3 (4%) 9 (12%) 1 (1%) 4 (5%)
Hyperplasia, Lymphoid 2 (3%) 2 (3%) 1 (1%) 3 (4%)
Artery, Inflammation, Chronic Active 1 (1%)
Capsule, Inflammation, Chronic 1 (1%)
Epithelial Cell, Hyperplasia 1 (1%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (79) (79) (75) (80)
Hyperplasia, Cystic 1 (1%) 1 (1%) 2 (3%)
Skin (80) (80) (78) (80)
Inflammation, Chronic Active 1 (1%) 1 (1%)
Ulcer 1 (1%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (80) (80) (78) (80)
Joint, Inflammation, Chronic Active 2 (3%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (80) (80) (78) (80)
Necrosis 3 (4%) 1 (1%) 3 (4%)
Peripheral Nerve (95) (95) (93) (95)
Axon, Degeneration 5 (5%) 6 (6%) 4 (4%) 12 (13%)
Spinal Cord (95) (95) (93) (95)
Degeneration 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (80) (80) (78) (80)
Hyperplasia, Lymphoid 1 (1%)
Inflammation, Chronic Active 3 (4%) 2 (3%)
Thrombosis 1 (1%)
Alveolar Epithelium, Hyperplasia 3 (4%) 1 (1%) 2 (3%) 1 (1%)
Artery, Inflammation, Chronic Active 2 (3%)
Pleura, Inflammation, Chronic 1 (1%)
Nose (80) (80) (78) (80)
Nasolacrimal Duct, Inflammation 1 (1%)
Respiratory Epithelium, Inflammation 2 (3%) 3 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cornea, Inflammation 1 (100%)
Harderian Gland (70) (60) (51) (60)
Hemorrhage 1 (2%)
Hyperplasia 3 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (80) (80) (78) (80)
Hydronephrosis 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Infarct 2 (3%) 1 (1%) 1 (1%) 1 (1%)
Mineralization 1 (1%)
Nephropathy 31 (39%) 31 (39%) 42 (54%) 38 (48%)
Pigmentation, Hemosiderin 1 (1%)
Artery, Inflammation, Chronic Active 1 (1%)
Renal Tubule, Dilatation 1 (1%)
Urinary Bladder (79) (80) (77) (80)
Artery, Inflammation, Chronic Active 1 (1%) 2 (3%)
Serosa, Inflammation, Chronic 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 95 95 95 95
Scheduled Sacrifice 43 45 45 45
Early Deaths
Moribund Sacrifice 4 1 1 2
Accidently Killed 1
Natural Death 4 5 4 6
Survivors
Terminal Sacrifice 43 43 44 42
Missing 1 1
Animals Examined Microscopically 95 94 94 95
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (80) (79) (79) (80)
Inflammation 1 (1%)
Gallbladder (78) (77) (76) (75)
Hyperplasia 1 (1%)
Intestine Small, Duodenum (80) (79) (79) (80)
Thrombosis 1 (1%)
Intestine Small, Jejunum (79) (79) (79) (80)
Serosa, Fibrosis 1 (1%)
Liver (80) (79) (79) (80)
Angiectasis 1 (1%)
Basophilic Focus 1 (1%) 3 (4%) 5 (6%)
Clear Cell Focus 5 (6%) 9 (11%) 18 (23%) 12 (15%)
Eosinophilic Focus 7 (9%) 4 (5%) 10 (13%) 5 (6%)
Erythrophagocytosis 1 (1%)
Fatty Change 7 (9%) 13 (16%) 28 (35%) 27 (34%)
Hematopoietic Cell Proliferation 1 (1%)
Mixed Cell Focus 1 (1%) 2 (3%)
Necrosis 2 (3%) 2 (3%) 3 (4%) 4 (5%)
Pigmentation, Ceroid 34 (43%) 31 (39%)
Vacuolization Cytoplasmic, Focal 1 (1%)
Bile Duct, Cyst 1 (1%)
Bile Duct, Hyperplasia 1 (1%)
Serosa, Inflammation 1 (1%)
Mesentery (2) (2)
Inflammation, Chronic Active 1 (50%)
Fat, Necrosis 1 (50%) 2 (100%)
Pancreas (80) (79) (79) (80)
Atrophy 3 (4%) 5 (6%) 3 (4%) 1 (1%)
Cyst 1 (1%)
Duct, Cyst 1 (1%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Salivary Glands (80) (79) (79) (80)
Duct, Hyperplasia 1 (1%)
Stomach, Forestomach (80) (79) (79) (80)
Hyperplasia 2 (3%) 1 (1%) 1 (1%)
Stomach, Glandular (80) (79) (79) (80)
Erosion 1 (1%) 1 (1%)
Hyperplasia 1 (1%) 1 (1%)
Tooth (3) (3) (2) (1)
Inflammation, Chronic Active 1 (33%) 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Polyarteritis 1 (100%)
Heart (80) (79) (79) (80)
Inflammation, Chronic Active 3 (4%) 1 (1%)
Mineralization 2 (3%) 2 (3%)
Artery, Inflammation, Chronic Active 1 (1%)
Atrium, Thrombosis 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (80) (79) (79) (80)
Accessory Adrenal Cortical Nodule 2 (3%) 2 (3%) 3 (4%) 4 (5%)
Hyperplasia 26 (33%) 23 (29%) 31 (39%) 26 (33%)
Pigmentation, Ceroid 68 (85%) 70 (89%) 72 (91%) 75 (94%)
Subcapsular, Hyperplasia 62 (78%) 64 (81%) 64 (81%) 61 (76%)
Adrenal Medulla (79) (79) (79) (78)
Hyperplasia 3 (4%) 1 (1%) 2 (3%)
Islets, Pancreatic (80) (79) (79) (80)
Hyperplasia 9 (11%) 11 (14%) 10 (13%) 15 (19%)
Parathyroid Gland (74) (69) (71) (72)
Cyst 1 (1%)
Pituitary Gland (78) (79) (74) (74)
Cyst 4 (5%) 2 (3%) 4 (5%)
Pars Distalis, Hyperplasia 2 (3%) 1 (1%) 2 (3%) 2 (3%)
Thyroid Gland (80) (79) (79) (80)
Follicle, Cyst 1 (1%) 1 (1%) 1 (1%)
Follicular Cell, Hyperplasia 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (80) (79) (79) (80)
Atrophy 1 (1%)
Granuloma Sperm 4 (5%)
Inflammation, Chronic Active 2 (3%)
Inflammation, Granulomatous 2 (3%)
Preputial Gland (45) (39) (46) (45)
Atrophy 1 (2%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 6 (13%) 4 (10%) 3 (7%) 3 (7%)
Duct, Dilatation 44 (98%) 38 (97%) 45 (98%) 44 (98%)
Prostate (80) (79) (79) (80)
Inflammation, Suppurative 1 (1%)
Seminal Vesicle (80) (79) (79) (80)
Dilatation 1 (1%)
Hemorrhage, Acute 1 (1%)
Inflammation, Chronic Active 1 (1%) 2 (3%)
Testes (80) (79) (79) (80)
Atrophy 1 (1%) 2 (3%) 3 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (80) (79) (79) (80)
Granuloma 1 (1%) 1 (1%)
Hyperplasia 7 (9%) 10 (13%) 9 (11%) 8 (10%)
Myelofibrosis 1 (1%)
Lymph Node (1) (2) (1)
Inguinal, Hyperplasia, Lymphoid 1 (100%)
Lymph Node, Mandibular (78) (75) (73) (75)
Depletion Lymphoid 1 (1%)
Hematopoietic Cell Proliferation 2 (3%)
Hyperplasia, Lymphoid 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Lymph Node, Mesenteric (76) (76) (76) (76)
Cyst 1 (1%)
Hematopoietic Cell Proliferation 1 (1%) 1 (1%) 2 (3%)
Hyperplasia, Lymphoid 1 (1%)
Spleen (80) (79) (79) (79)
Angiectasis 2 (3%) 1 (1%)
Depletion Lymphoid 5 (6%) 4 (5%) 2 (3%)
Hematocyst 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hematopoietic Cell Proliferation 15 (19%) 19 (24%) 15 (19%) 18 (23%)
Hyperplasia, Lymphoid 1 (1%) 1 (1%) 2 (3%)
Thymus (73) (72) (74) (75)
Atrophy 2 (3%)
Cyst 1 (1%)
Depletion Lymphoid 4 (5%) 3 (4%) 3 (4%) 9 (12%)
Hyperplasia, Lymphoid 1 (1%)
Necrosis 1 (1%)
Epithelial Cell, Hyperplasia 1 (1%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (80) (79) (79) (80)
Abscess 1 (1%)
Cyst Epithelial Inclusion 1 (1%) 1 (1%)
Granuloma 1 (1%)
Hemorrhage 1 (1%)
Inflammation, Chronic Active 1 (1%) 1 (1%)
Ulcer 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (80) (79) (79) (80)
Infiltration Cellular, Lipocyte 1 (1%)
Necrosis 1 (1%) 1 (1%) 1 (1%)
Peripheral Nerve (95) (94) (94) (95)
Axon, Degeneration 4 (4%) 2 (2%) 3 (3%) 3 (3%)
Spinal Cord (95) (94) (94) (95)
Cyst 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (80) (79) (79) (80)
Inflammation, Chronic Active 1 (1%) 6 (8%)
Thrombosis 1 (1%)
Alveolar Epithelium, Hyperplasia 3 (4%) 5 (6%) 2 (3%) 2 (3%)
Alveolus, Pigmentation, Hemosiderin 1 (1%)
Bronchiole, Hyperplasia 1 (1%) 1 (1%)
Nose (80) (79) (79) (80)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Developmental Malformation 1 (1%)
Proliferation Connective Tissue 1 (1%)
Nasolacrimal Duct, Inflammation 1 (1%) 2 (3%)
Respiratory Epithelium, Inflammation 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (1)
Atrophy 1 (100%)
Cornea, Inflammation 1 (100%) 1 (100%)
Harderian Gland (71) (63) (66) (60)
Hyperplasia 2 (3%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (80) (79) (79) (80)
Cyst 2 (3%) 5 (6%) 3 (4%) 1 (1%)
Hydronephrosis 1 (1%) 1 (1%)
Infarct 2 (3%) 1 (1%) 1 (1%)
Inflammation, Suppurative 2 (3%)
Nephropathy 61 (76%) 62 (78%) 62 (78%) 59 (74%)
Artery, Inflammation, Chronic Active 1 (1%)
Renal Tubule, Necrosis 1 (1%)
Urinary Bladder (80) (79) (79) (79)
Inflammation, Suppurative 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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