TDMS Study 05100-04 Pathology Tables
NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 Facility: Battelle Columbus Laboratory Chemical CAS #: 1330-78-5 Lock Date: 12/13/91 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 2| 2| 2| 2| 2| 2| 2| 4| 2| 4| 4| 0| 4| 4| 0| 0| 2| 2| 4| 4| 0| 0| 2| 4| DAY ON TEST | 9| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 6| 9| 6| 6| 9| 9| 8| 8| 6| 6| 9| 9| 8| 6| | 0| 2| 6| 2| 2| 2| 2| 6| 2| 6| 1| 2| 0| 1| 1| 7| 7| 2| 6| 1| 1| 1| 0| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | | Hepatocellular Adenoma, Multiple | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Mesentery | + | Fibrosarcoma, Metastatic, Skin | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + +| Adenoma | | Subcapsular, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + M + + M + +| Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 2| 2| 2| 2| 2| 2| 2| 4| 2| 4| 4| 0| 4| 4| 0| 0| 2| 2| 4| 4| 0| 0| 2| 4| DAY ON TEST | 9| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 6| 9| 6| 6| 9| 9| 8| 8| 6| 6| 9| 9| 8| 6| | 0| 2| 6| 2| 2| 2| 2| 6| 2| 6| 1| 2| 0| 1| 1| 7| 7| 2| 6| 1| 1| 1| 0| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Leiomyoma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | | Teratoma NOS | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Polyp Stromal | | Polyp Stromal, Multiple | | Serosa, Fibrosarcoma, Metastatic, | | Skin | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | Axillary, Renal, Mediastinal, | | Lymphoma Malignant Mixed | | Mediastinal, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | Mediastinal, Lymphoma Malignant Mixed| | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 2| 2| 2| 2| 2| 2| 2| 4| 2| 4| 4| 0| 4| 4| 0| 0| 2| 2| 4| 4| 0| 0| 2| 4| DAY ON TEST | 9| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 6| 9| 6| 6| 9| 9| 8| 8| 6| 6| 9| 9| 8| 6| | 0| 2| 6| 2| 2| 2| 2| 6| 2| 6| 1| 2| 0| 1| 1| 7| 7| 2| 6| 1| 1| 1| 0| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + +| Fibrosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Fibrosarcoma, Multiple, Metastatic, | | Skin | | Sarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, | | Harderian Gland | | Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Fibrosarcoma, Metastatic, Skin | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + M + + + + + + M + M + + M + + +| Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + +| Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 2| 2| 2| 2| 2| 2| 2| 4| 2| 4| 4| 0| 4| 4| 0| 0| 2| 2| 4| 4| 0| 0| 2| 4| DAY ON TEST | 9| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 6| 9| 6| 6| 9| 9| 8| 8| 6| 6| 9| 9| 8| 6| | 0| 2| 6| 2| 2| 2| 2| 6| 2| 6| 1| 2| 0| 1| 1| 7| 7| 2| 6| 1| 1| 1| 0| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 4| 4| 2| 0| 2| 0| 0| 0| 0| 2| 0| 2| 4| 4| 0| 4| 4| 4| 0| 7| 7| 7| 6| 7| DAY ON TEST | 9| 6| 6| 8| 9| 8| 9| 9| 9| 9| 8| 9| 8| 6| 6| 9| 6| 6| 6| 9| 3| 3| 1| 9| 3| | 7| 1| 2| 2| 0| 6| 1| 1| 7| 7| 2| 1| 2| 1| 2| 1| 1| 2| 1| 0| 9| 9| 2| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 0 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 9| 9| 9| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + +| Lymphoid Tissue, Lymphoma Malignant | | Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X| Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X | Hepatocellular Adenoma, Multiple | X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Mesentery | + + | Fibrosarcoma, Metastatic, Skin | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + +| Adenoma | | Subcapsular, Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + M M + + + + + + M + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 4| 4| 2| 0| 2| 0| 0| 0| 0| 2| 0| 2| 4| 4| 0| 4| 4| 4| 0| 7| 7| 7| 6| 7| DAY ON TEST | 9| 6| 6| 8| 9| 8| 9| 9| 9| 9| 8| 9| 8| 6| 6| 9| 6| 6| 6| 9| 3| 3| 1| 9| 3| | 7| 1| 2| 2| 0| 6| 1| 1| 7| 7| 2| 1| 2| 1| 2| 1| 1| 2| 1| 0| 9| 9| 2| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 0 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 9| 9| 9| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + M| Pars Distalis, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Leiomyoma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | | Teratoma NOS | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Polyp Stromal | | Polyp Stromal, Multiple | | Serosa, Fibrosarcoma, Metastatic, | | Skin | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Axillary, Renal, Mediastinal, | | Lymphoma Malignant Mixed | X | Mediastinal, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | Mediastinal, Lymphoma Malignant Mixed| | __________________________________________________________________________| Lymph Node, Mandibular | + + + + M + + + + + + + + + + M + +| Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + M + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X| Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + M + M| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 4| 4| 2| 0| 2| 0| 0| 0| 0| 2| 0| 2| 4| 4| 0| 4| 4| 4| 0| 7| 7| 7| 6| 7| DAY ON TEST | 9| 6| 6| 8| 9| 8| 9| 9| 9| 9| 8| 9| 8| 6| 6| 9| 6| 6| 6| 9| 3| 3| 1| 9| 3| | 7| 1| 2| 2| 0| 6| 1| 1| 7| 7| 2| 1| 2| 1| 2| 1| 1| 2| 1| 0| 9| 9| 2| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 0 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 9| 9| 9| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + +| Fibrosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Fibrosarcoma, Multiple, Metastatic, | | Skin | | Sarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, | | Harderian Gland | | Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Fibrosarcoma, Metastatic, Skin | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + M + + + + + + + M M + + + + + +| Adenoma | X| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 4| 4| 2| 0| 2| 0| 0| 0| 0| 2| 0| 2| 4| 4| 0| 4| 4| 4| 0| 7| 7| 7| 6| 7| DAY ON TEST | 9| 6| 6| 8| 9| 8| 9| 9| 9| 9| 8| 9| 8| 6| 6| 9| 6| 6| 6| 9| 3| 3| 1| 9| 3| | 7| 1| 2| 2| 0| 6| 1| 1| 7| 7| 2| 1| 2| 1| 2| 1| 1| 2| 1| 0| 9| 9| 2| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 0 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 9| 9| 9| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| | 9| 9| 9| 9| 9| 7| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Mixed | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X| Hepatocellular Adenoma, Multiple | X X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Mesentery | + | Fibrosarcoma, Metastatic, Skin | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Subcapsular, Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + M + + M + + M + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| | 9| 9| 9| 9| 9| 7| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + + + + + M + M + + + + + + +| Pars Distalis, Adenoma | X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Leiomyoma | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | __________________________________________________________________________| Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | | Teratoma NOS | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Polyp Stromal | | Polyp Stromal, Multiple | X | Serosa, Fibrosarcoma, Metastatic, | | Skin | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Axillary, Renal, Mediastinal, | | Lymphoma Malignant Mixed | | Mediastinal, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | Mediastinal, Lymphoma Malignant Mixed| X | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + M + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + + + + + + + M + + +| Lymphoma Malignant Mixed | X X | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| | 9| 9| 9| 9| 9| 7| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + | Fibrosarcoma, Multiple, Metastatic, | | Skin | X | Sarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, | | Harderian Gland | | Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Fibrosarcoma, Metastatic, Skin | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + M + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| | 9| 9| 9| 9| 9| 7| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| | | DAY ON TEST | 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 2| 4| 4| 4| | | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 8| 3| 0| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 79 | Lymphoid Tissue, Lymphoma Malignant | | | Mixed | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 80 | Hepatocellular Carcinoma | X X X X X X X | 9 | Hepatocellular Carcinoma, Multiple | X | 1 | Hepatocellular Adenoma | X | 8 | Hepatocellular Adenoma, Multiple | X X | 5 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Mesentery | + + | 6 | Fibrosarcoma, Metastatic, Skin | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 80 | Hemangiosarcoma | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 80 | Adenoma | X | 1 | Subcapsular, Adenoma | X | 3 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 80 | Pheochromocytoma Benign | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| | | DAY ON TEST | 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 2| 4| 4| 4| | | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 8| 3| 0| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 80 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + | 71 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 76 | Pars Distalis, Adenoma | | 6 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 79 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Leiomyoma | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 2 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + M + + + + + + + | 78 | Granulosa Cell Tumor Malignant | X | 1 | Teratoma NOS | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 80 | Histiocytic Sarcoma | X | 1 | Polyp Stromal | X | 1 | Polyp Stromal, Multiple | | 1 | Serosa, Fibrosarcoma, Metastatic, | | | Skin | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Lymph Node | + | 3 | Axillary, Renal, Mediastinal, | | | Lymphoma Malignant Mixed | | 1 | Mediastinal, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | X | 1 | Mediastinal, Lymphoma Malignant Mixed| | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + | 75 | Lymphoma Malignant Mixed | | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| | | DAY ON TEST | 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 2| 4| 4| 4| | | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 8| 3| 0| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 80 | Hemangiosarcoma | X X | 3 | Lymphoma Malignant Mixed | | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + M + + + + + + + + + + + + + | 75 | Lymphoma Malignant Mixed | | 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 80 | Fibrosarcoma | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Skeletal Muscle | | 2 | Fibrosarcoma, Multiple, Metastatic, | | | Skin | | 1 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 95 | __________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 95 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 80 | Adenocarcinoma, Metastatic, | | | Harderian Gland | X | 1 | Alveolar/Bronchiolar Adenoma | | 2 | Alveolar/Bronchiolar Carcinoma | X X | 3 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 1 | Fibrosarcoma, Metastatic, Skin | | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| | | DAY ON TEST | 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 2| 4| 4| 4| | | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 8| 3| 0| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 79 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + M + M + + + | 70 | Adenoma | X X X | 5 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 80 | Renal Tubule, Adenoma | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + M + + + + + + + + | 79 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 95 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Mixed | | 3 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 0| 0| 4| 0| 2| 4| 0| 4| 0| 2| 0| 2| 4| 0| DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 9| 9| 6| 9| 8| 6| 9| 6| 9| 8| 9| 8| 6| 9| | 2| 2| 6| 2| 1| 2| 1| 6| 2| 1| 7| 1| 0| 2| 1| 6| 2| 7| 1| 7| 6| 1| 2| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 60 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Lymphocytic | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Spleen | | Hepatocellular Carcinoma | | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | | Hepatocellular Adenoma, Multiple | | Hepatocholangiocarcinoma | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Mesentery | | Fibrosarcoma, Metastatic, Skin | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 0| 0| 4| 0| 2| 4| 0| 4| 0| 2| 0| 2| 4| 0| DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 9| 9| 6| 9| 8| 6| 9| 6| 9| 8| 9| 8| 6| 9| | 2| 2| 6| 2| 1| 2| 1| 6| 2| 1| 7| 1| 0| 2| 1| 6| 2| 7| 1| 7| 6| 1| 2| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 60 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Luteoma | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | Bronchial, Lymphoma Malignant | | Undifferentiated Cell Type | | Mediastinal, Histiocytic Sarcoma | | Mediastinal, Lymphoma Malignant | | Lymphocytic | | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | | Pancreatic, Hepatocholangiocarcinoma,| | Metastatic, Liver | | Pancreatic, Lymphoma Malignant | | Lymphocytic | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 0| 0| 4| 0| 2| 4| 0| 4| 0| 2| 0| 2| 4| 0| DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 9| 9| 6| 9| 8| 6| 9| 6| 9| 8| 9| 8| 6| 9| | 2| 2| 6| 2| 1| 2| 1| 6| 2| 1| 7| 1| 0| 2| 1| 6| 2| 7| 1| 7| 6| 1| 2| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 60 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + M + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + +| Fibrosarcoma | | Subcutaneous Tissue, Myxosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + +| Meninges, Myxosarcoma, Metastatic, | | Skin | | __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + M + + + + M + + + + + + M +| Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 0| 0| 4| 0| 2| 4| 0| 4| 0| 2| 0| 2| 4| 0| DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 9| 9| 6| 9| 8| 6| 9| 6| 9| 8| 9| 8| 6| 9| | 2| 2| 6| 2| 1| 2| 1| 6| 2| 1| 7| 1| 0| 2| 1| 6| 2| 7| 1| 7| 6| 1| 2| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 60 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 0| 0| 4| 4| 4| 0| 4| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 2| 4| 7| 7| 7| 7| DAY ON TEST | 8| 9| 9| 6| 6| 6| 9| 6| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 8| 5| 3| 3| 3| 3| | 2| 7| 0| 1| 1| 2| 7| 1| 1| 1| 2| 0| 1| 0| 1| 6| 2| 2| 2| 2| 4| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 6| 60 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Lymphocytic | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Spleen | | Hepatocellular Carcinoma | | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X| Hepatocellular Adenoma, Multiple | | Hepatocholangiocarcinoma | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Mesentery | | Fibrosarcoma, Metastatic, Skin | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + M + + + + M M + + + + + + + +| _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 0| 0| 4| 4| 4| 0| 4| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 2| 4| 7| 7| 7| 7| DAY ON TEST | 8| 9| 9| 6| 6| 6| 9| 6| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 8| 5| 3| 3| 3| 3| | 2| 7| 0| 1| 1| 2| 7| 1| 1| 1| 2| 0| 1| 0| 1| 6| 2| 2| 2| 2| 4| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 6| 60 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Luteoma | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | Bronchial, Lymphoma Malignant | | Undifferentiated Cell Type | | Mediastinal, Histiocytic Sarcoma | | Mediastinal, Lymphoma Malignant | | Lymphocytic | | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | | Pancreatic, Hepatocholangiocarcinoma,| | Metastatic, Liver | | Pancreatic, Lymphoma Malignant | | Lymphocytic | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 0| 0| 4| 4| 4| 0| 4| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 2| 4| 7| 7| 7| 7| DAY ON TEST | 8| 9| 9| 6| 6| 6| 9| 6| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 8| 5| 3| 3| 3| 3| | 2| 7| 0| 1| 1| 2| 7| 1| 1| 1| 2| 0| 1| 0| 1| 6| 2| 2| 2| 2| 4| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 6| 60 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | | Subcutaneous Tissue, Myxosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + +| Meninges, Myxosarcoma, Metastatic, | | Skin | | __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + M M + M M + + M + + + + + + M + + +| Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 0| 0| 4| 4| 4| 0| 4| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 2| 4| 7| 7| 7| 7| DAY ON TEST | 8| 9| 9| 6| 6| 6| 9| 6| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 8| 5| 3| 3| 3| 3| | 2| 7| 0| 1| 1| 2| 7| 1| 1| 1| 2| 0| 1| 0| 1| 6| 2| 2| 2| 2| 4| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 6| 60 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| | 8| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + M +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Lymphocytic | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Spleen | | Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | | Hepatocholangiocarcinoma | | Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Mesentery | + + + | Fibrosarcoma, Metastatic, Skin | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + M + M M + M M + M + + + + + + M M +| _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| | 8| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X| Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Luteoma | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + | Bronchial, Lymphoma Malignant | | Undifferentiated Cell Type | X | Mediastinal, Histiocytic Sarcoma | X | Mediastinal, Lymphoma Malignant | | Lymphocytic | X | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | X | Pancreatic, Hepatocholangiocarcinoma,| | Metastatic, Liver | | Pancreatic, Lymphoma Malignant | | Lymphocytic | X | __________________________________________________________________________| Lymph Node, Mandibular | + M + M + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + M +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | X | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| | 8| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Thymus | + M + + + + + M + + + + M M + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | X | Subcutaneous Tissue, Myxosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Myxosarcoma, Metastatic, | | Skin | | __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + M + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + + + + M M + + M M + M M + + M + + + + + + + +| Adenoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| | 8| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 6| | | DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 9| 5| 3| 4| 3| 3| 3| 0| | | | 0| 9| 9| 9| 9| 9| 9| 9| 3| 9| 1| 9| 6| 2| 9| 5| 9| 9| 9| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Gallbladder | M + + + + + + + + + + + + + + + + + + + | 78 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + | 78 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 80 | Lymphoid Tissue, Lymphoma Malignant | | | Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 80 | Hemangiosarcoma, Metastatic, Spleen | X | 1 | Hepatocellular Carcinoma | | 2 | Hepatocellular Carcinoma, Multiple | X | 1 | Hepatocellular Adenoma | X X | 12 | Hepatocellular Adenoma, Multiple | X | 1 | Hepatocholangiocarcinoma | X | 1 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Mesentery | + + | 5 | Fibrosarcoma, Metastatic, Skin | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 80 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 80 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 80 | Histiocytic Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 6| | | DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 9| 5| 3| 4| 3| 3| 3| 0| | | | 0| 9| 9| 9| 9| 9| 9| 9| 3| 9| 1| 9| 6| 2| 9| 5| 9| 9| 9| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + M + + + + + + | 79 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + M + + + + + + | 79 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Pituitary Gland | + + + + M M M + + + + + + + M + + + + + | 76 | Pars Distalis, Adenoma | X | 8 | Pars Intermedia, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 80 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + | 80 | Histiocytic Sarcoma | X | 1 | Luteoma | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 80 | Histiocytic Sarcoma | X X | 2 | Polyp Stromal | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Lymph Node | + | 4 | Bronchial, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Mediastinal, Histiocytic Sarcoma | | 1 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | | 1 | Mediastinal, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Pancreatic, Hepatocholangiocarcinoma,| | | Metastatic, Liver | X | 1 | Pancreatic, Lymphoma Malignant | | | Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 77 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 6| | | DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 9| 5| 3| 4| 3| 3| 3| 0| | | | 0| 9| 9| 9| 9| 9| 9| 9| 3| 9| 1| 9| 6| 2| 9| 5| 9| 9| 9| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M + + + + M + + + + + + + + + + + + | 75 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 80 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant Lymphocytic | X | 3 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 3 | __________________________________________________________________________|____________| Thymus | M + + M + + + + + + + + + + + + + + + + | 74 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 80 | Fibrosarcoma | | 1 | Subcutaneous Tissue, Myxosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 80 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 80 | Meninges, Myxosarcoma, Metastatic, | | | Skin | X | 1 | __________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 95 | __________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 95 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 80 | Alveolar/Bronchiolar Adenoma | X X X | 4 | Alveolar/Bronchiolar Carcinoma | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 6| | | DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 9| 5| 3| 4| 3| 3| 3| 0| | | | 0| 9| 9| 9| 9| 9| 9| 9| 3| 9| 1| 9| 6| 2| 9| 5| 9| 9| 9| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 79 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + M + + + + M + M M + + + | 60 | Adenoma | X | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 80 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 95 | Histiocytic Sarcoma | X X | 3 | Lymphoma Malignant Lymphocytic | X | 3 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 0| 0| 4| 0| 2| 4| 0| 4| 0| 2| 0| 2| 4| 0| DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 9| 9| 6| 9| 8| 6| 9| 6| 9| 8| 9| 8| 6| 9| | 2| 2| 6| 2| 1| 2| 1| 6| 2| 1| 7| 1| 0| 2| 1| 6| 2| 7| 1| 7| 6| 1| 2| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 125 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Hepatocellular Adenoma | | Hepatocellular Adenoma, Multiple | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + M + + + + M + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 0| 0| 4| 0| 2| 4| 0| 4| 0| 2| 0| 2| 4| 0| DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 9| 9| 6| 9| 8| 6| 9| 6| 9| 8| 9| 8| 6| 9| | 2| 2| 6| 2| 1| 2| 1| 6| 2| 1| 7| 1| 0| 2| 1| 6| 2| 7| 1| 7| 6| 1| 2| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 125 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + +| Cystadenoma | | Hemangioma | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + +| Hemangioma | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node | | Lumbar, Renal, Thoracic, Iliac, | | Bronchial, Mediastinal, | | Lymphoma Malignant Mixed | | Renal, Histiocytic Sarcoma | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + +| Hemangioma | | Hemangiosarcoma | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Thymoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + M + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + +| Fibrosarcoma | | Hemangioma | | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 0| 0| 4| 0| 2| 4| 0| 4| 0| 2| 0| 2| 4| 0| DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 9| 9| 6| 9| 8| 6| 9| 6| 9| 8| 9| 8| 6| 9| | 2| 2| 6| 2| 1| 2| 1| 6| 2| 1| 7| 1| 0| 2| 1| 6| 2| 7| 1| 7| 6| 1| 2| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 125 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Pinna, Fibrosarcoma | | __________________________________________________________________________| Harderian Gland | + M M + + + + + + + + + + M +| Adenocarcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 0| 0| 4| 4| 4| 0| 4| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 2| 7| 7| 7| 7| 7| DAY ON TEST | 8| 9| 9| 6| 6| 6| 9| 6| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 8| 3| 3| 3| 3| 3| | 2| 7| 0| 1| 1| 2| 7| 1| 1| 1| 2| 0| 1| 0| 1| 6| 2| 2| 2| 2| 7| 7| 7| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 9| 9| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Mesentery | +| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + M + + + + M + + M + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 0| 0| 4| 4| 4| 0| 4| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 2| 7| 7| 7| 7| 7| DAY ON TEST | 8| 9| 9| 6| 6| 6| 9| 6| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 8| 3| 3| 3| 3| 3| | 2| 7| 0| 1| 1| 2| 7| 1| 1| 1| 2| 0| 1| 0| 1| 6| 2| 2| 2| 2| 7| 7| 7| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 9| 9| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + +| Cystadenoma | | Hemangioma | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node | +| Lumbar, Renal, Thoracic, Iliac, | | Bronchial, Mediastinal, | | Lymphoma Malignant Mixed | | Renal, Histiocytic Sarcoma | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Hemangiosarcoma | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Thymoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | | Hemangioma | | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 0| 0| 4| 4| 4| 0| 4| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 2| 7| 7| 7| 7| 7| DAY ON TEST | 8| 9| 9| 6| 6| 6| 9| 6| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 8| 3| 3| 3| 3| 3| | 2| 7| 0| 1| 1| 2| 7| 1| 1| 1| 2| 0| 1| 0| 1| 6| 2| 2| 2| 2| 7| 7| 7| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 9| 9| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Pinna, Fibrosarcoma | | __________________________________________________________________________| Harderian Gland | M + + + M + + + + M + M M + + M + + + +| Adenocarcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | X X | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Mesentery | + + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + + M + + + + + + + M + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + M + + + + + + + +| Cystadenoma | X | Hemangioma | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | X | Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node | + | Lumbar, Renal, Thoracic, Iliac, | | Bronchial, Mediastinal, | | Lymphoma Malignant Mixed | X | Renal, Histiocytic Sarcoma | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | Hemangiosarcoma | | Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Thymoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | X | Hemangioma | | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + + | Pinna, Fibrosarcoma | X | __________________________________________________________________________| Harderian Gland | M + + + + + + M M M M M + M + + M + + M M M M +| Adenocarcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 7| 3| | | | 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 1| 3| 8| 8| 8| 8| 8| 8| 8| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + | 77 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + | 77 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + | 77 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + | 77 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + | 78 | Hepatocellular Carcinoma | X | 1 | Hepatocellular Adenoma | X X X | 10 | Hepatocellular Adenoma, Multiple | X | 3 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Mesentery | + | 6 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + | 78 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + | 78 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + | 78 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + | 78 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + | 78 | Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + | 66 | __________________________________________________________________________|____________| Pituitary Gland | + + + M + + + + + + + + + M + + + + + | 76 | Pars Distalis, Adenoma | X X X X | 6 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + | 78 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 7| 3| | | | 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 1| 3| 8| 8| 8| 8| 8| 8| 8| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + | 77 | Cystadenoma | | 1 | Hemangioma | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + | 78 | Hemangioma | X | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 2 | Polyp Stromal | X X X | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + | 78 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________|____________| Lymph Node | + | 3 | Lumbar, Renal, Thoracic, Iliac, | | | Bronchial, Mediastinal, | | | Lymphoma Malignant Mixed | | 1 | Renal, Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + | 78 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + M + | 75 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + | 78 | Hemangioma | | 1 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + M + + + + + + + + + + + | 77 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | | 1 | Thymoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 7| 3| | | | 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 1| 3| 8| 8| 8| 8| 8| 8| 8| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + M + + + + + + + | 75 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + | 78 | Fibrosarcoma | | 1 | Hemangioma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + | 93 | __________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + | 93 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + | 78 | Alveolar/Bronchiolar Adenoma | X X | 3 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | X X | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + | 78 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 2 | Pinna, Fibrosarcoma | | 1 | __________________________________________________________________________|____________| Harderian Gland | + + M M + + + + M + M + + + M + + + M | 51 | Adenocarcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 7| 3| | | | 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 1| 3| 8| 8| 8| 8| 8| 8| 8| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + | 77 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + | 93 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant Lymphocytic | | 3 | Lymphoma Malignant Mixed | | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 4| 2| 4| 4| 2| 0| 4| 2| 0| 0| 0| 2| 0| 0| 0| 4| 0| 4| 0| 2| 4| 0| 2| 0| DAY ON TEST | 8| 6| 8| 6| 6| 8| 9| 6| 8| 9| 9| 9| 8| 9| 9| 7| 6| 9| 6| 9| 8| 6| 9| 8| 9| | 2| 2| 6| 1| 1| 2| 0| 1| 2| 7| 7| 1| 2| 1| 1| 9| 1| 1| 2| 0| 6| 2| 0| 6| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 250 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + | Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + | Lymphoid Tissue, Lymphoma Malignant | | Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + | Hepatocellular Carcinoma | | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | | Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + | Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + M + + | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + M M + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + | Pars Distalis, Adenoma | | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 4| 2| 4| 4| 2| 0| 4| 2| 0| 0| 0| 2| 0| 0| 0| 4| 0| 4| 0| 2| 4| 0| 2| 0| DAY ON TEST | 8| 6| 8| 6| 6| 8| 9| 6| 8| 9| 9| 9| 8| 9| 9| 7| 6| 9| 6| 9| 8| 6| 9| 8| 9| | 2| 2| 6| 1| 1| 2| 0| 1| 2| 7| 7| 1| 2| 1| 1| 9| 1| 1| 2| 0| 6| 2| 0| 6| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 250 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + | Cystadenoma | | Fibrous Histiocytoma | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + | Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | Leukemia Lymphocytic | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + | Leukemia Lymphocytic | | Osteosarcoma, Metastatic, Bone | | Sarcoma | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + | Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + | Hemangiosarcoma | | Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + | Adenocarcinoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + | Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + | Vertebra, Osteosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 4| 2| 4| 4| 2| 0| 4| 2| 0| 0| 0| 2| 0| 0| 0| 4| 0| 4| 0| 2| 4| 0| 2| 0| DAY ON TEST | 8| 6| 8| 6| 6| 8| 9| 6| 8| 9| 9| 9| 8| 9| 9| 7| 6| 9| 6| 9| 8| 6| 9| 8| 9| | 2| 2| 6| 1| 1| 2| 0| 1| 2| 7| 7| 1| 2| 1| 1| 9| 1| 1| 2| 0| 6| 2| 0| 6| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 250 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + | Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Osteosarcoma, Multiple, Metastatic, | | Bone | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + M + + + + + + M + + + + + M | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + | Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 7| 4| 7| 7| 7| DAY ON TEST | 6| 9| 6| 9| 6| 6| 6| 9| 8| 6| 8| 8| 6| 9| 8| 8| 8| 8| 8| 9| 3| 7| 3| 3| 3| | 1| 0| 1| 0| 1| 1| 2| 7| 6| 1| 2| 2| 2| 7| 6| 2| 2| 2| 2| 1| 6| 1| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Mixed | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | | Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M M + + + + + M + + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 7| 4| 7| 7| 7| DAY ON TEST | 6| 9| 6| 9| 6| 6| 6| 9| 8| 6| 8| 8| 6| 9| 8| 8| 8| 8| 8| 9| 3| 7| 3| 3| 3| | 1| 0| 1| 0| 1| 1| 2| 7| 6| 1| 2| 2| 2| 7| 6| 2| 2| 2| 2| 1| 6| 1| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + +| Cystadenoma | | Fibrous Histiocytoma | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | Leukemia Lymphocytic | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + +| Leukemia Lymphocytic | | Osteosarcoma, Metastatic, Bone | X | Sarcoma | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + +| Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Thymus | + + + + M + + + + + + + + + M + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + +| Sarcoma | X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + +| Vertebra, Osteosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 7| 4| 7| 7| 7| DAY ON TEST | 6| 9| 6| 9| 6| 6| 6| 9| 8| 6| 8| 8| 6| 9| 8| 8| 8| 8| 8| 9| 3| 7| 3| 3| 3| | 1| 0| 1| 0| 1| 1| 2| 7| 6| 1| 2| 2| 2| 7| 6| 2| 2| 2| 2| 1| 6| 1| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X| Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Osteosarcoma, Multiple, Metastatic, | | Bone | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + + + + + + + M + M + + + M + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + +| Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 250 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X X X X | Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Mesentery | + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + M + + M M + + + M + + + M + + + +| __________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X | Pars Intermedia, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 250 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X | Fibrous Histiocytoma | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | Leukemia Lymphocytic | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Lymphocytic | | Osteosarcoma, Metastatic, Bone | | Sarcoma | | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + M + + + M + + +| Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Thymus | + + + + + + + M + + + + + + + + M + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Vertebra, Osteosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 250 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Osteosarcoma, Multiple, Metastatic, | | Bone | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | M + + + + M + M + M + + + + M M M + + + M + + + M| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Lymphocytic | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + | 80 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 80 | Osteosarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 80 | Lymphoid Tissue, Lymphoma Malignant | | | Mixed | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 80 | Hepatocellular Carcinoma | X X | 5 | Hepatocellular Carcinoma, Multiple | | 1 | Hepatocellular Adenoma | X X | 8 | Hepatocellular Adenoma, Multiple | X X X | 8 | Leukemia Lymphocytic | X | 1 | Lymphoma Malignant Lymphocytic | X | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Mesentery | | 3 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 80 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 80 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 80 | Adenoma | X | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 79 | Pars Distalis, Adenoma | X X X X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 56 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pars Intermedia, Adenoma | X | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 80 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 1 | __________________________________________________________________________|____________| Ovary | + M + + + + + + + + + + + + + + + + + + | 79 | Cystadenoma | X | 2 | Fibrous Histiocytoma | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 80 | Histiocytic Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + | 1 | Leukemia Lymphocytic | X | 1 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 | Leukemia Lymphocytic | X | 1 | Osteosarcoma, Metastatic, Bone | | 1 | Sarcoma | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 76 | Leukemia Lymphocytic | X | 1 | Lymphoma Malignant Lymphocytic | X X | 2 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + | 78 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 80 | Hemangiosarcoma | | 1 | Leukemia Lymphocytic | X | 1 | Lymphoma Malignant Lymphocytic | X | 2 | Lymphoma Malignant Mixed | X | 3 | __________________________________________________________________________|____________| Thymus | M + + + + + + + + + + M + + + + + + + + | 74 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 57 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Adenocarcinoma | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 80 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 80 | Vertebra, Osteosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 95 | __________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 95 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 80 | Alveolar/Bronchiolar Adenoma | X X | 5 | Alveolar/Bronchiolar Carcinoma | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 2 | Leukemia Lymphocytic | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 1 | Osteosarcoma, Multiple, Metastatic, | | | Bone | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 80 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + + + + M + + M M + M + + + + + M + + | 60 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 80 | Leukemia Lymphocytic | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 95 | Histiocytic Sarcoma | X | 1 | Leukemia Lymphocytic | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 58 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Lymphoma Malignant Lymphocytic | X X | 3 | Lymphoma Malignant Mixed | X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 0| 4| 4| 4| 2| 0| 4| 0| 0| 4| 4| 0| 0| 4| 2| 0| 0| 2| 2| 0| 0| 4| DAY ON TEST | 8| 8| 8| 9| 6| 6| 6| 8| 9| 6| 9| 9| 6| 6| 9| 9| 6| 8| 9| 9| 8| 8| 9| 9| 6| | 6| 1| 1| 6| 0| 2| 0| 1| 6| 0| 1| 6| 2| 0| 0| 0| 0| 1| 1| 0| 6| 1| 6| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + M + + + +| Adenoma | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Lymphocytic | | Lymphoid Tissue, Lymphoma Malignant | | Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + +| Hemangioma | | Hepatocellular Carcinoma | | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | Odontoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + +| Adenoma | | Bilateral, Subcapsular, Adenoma | | Subcapsular, Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + M + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + M M + + + + + + M + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 0| 4| 4| 4| 2| 0| 4| 0| 0| 4| 4| 0| 0| 4| 2| 0| 0| 2| 2| 0| 0| 4| DAY ON TEST | 8| 8| 8| 9| 6| 6| 6| 8| 9| 6| 9| 9| 6| 6| 9| 9| 6| 8| 9| 9| 8| 8| 9| 9| 6| | 6| 1| 1| 6| 0| 2| 0| 1| 6| 0| 1| 6| 2| 0| 0| 0| 0| 1| 1| 0| 6| 1| 6| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + M + M + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M + M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, | | Harderian Gland | | Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | _____________________________________________________________________________________________________________________| Page 61 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 0| 4| 4| 4| 2| 0| 4| 0| 0| 4| 4| 0| 0| 4| 2| 0| 0| 2| 2| 0| 0| 4| DAY ON TEST | 8| 8| 8| 9| 6| 6| 6| 8| 9| 6| 9| 9| 6| 6| 9| 9| 6| 8| 9| 9| 8| 8| 9| 9| 6| | 6| 1| 1| 6| 0| 2| 0| 1| 6| 0| 1| 6| 2| 0| 0| 0| 0| 1| 1| 0| 6| 1| 6| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Liver | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + +| Adenocarcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 62 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 4| 0| 2| 4| 0| 0| 4| 4| 2| 4| 4| 2| 2| 2| 2| 4| 2| 2| 0| 7| 7| 7| 7| 7| DAY ON TEST | 9| 6| 9| 8| 6| 4| 9| 6| 6| 8| 6| 6| 8| 8| 8| 8| 6| 8| 8| 9| 3| 3| 3| 3| 3| | 1| 0| 1| 1| 2| 0| 1| 0| 0| 1| 2| 0| 1| 1| 6| 6| 2| 1| 6| 6| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Lymphocytic | | Lymphoid Tissue, Lymphoma Malignant | | Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + +| Hemangioma | | Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | Odontoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + +| Adenoma | | Bilateral, Subcapsular, Adenoma | | Subcapsular, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | M M + M + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 63 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 4| 0| 2| 4| 0| 0| 4| 4| 2| 4| 4| 2| 2| 2| 2| 4| 2| 2| 0| 7| 7| 7| 7| 7| DAY ON TEST | 9| 6| 9| 8| 6| 4| 9| 6| 6| 8| 6| 6| 8| 8| 8| 8| 6| 8| 8| 9| 3| 3| 3| 3| 3| | 1| 0| 1| 1| 2| 0| 1| 0| 0| 1| 2| 0| 1| 1| 6| 6| 2| 1| 6| 6| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + + + + M + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + M| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + M +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M + + + M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, | | Harderian Gland | | Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | _____________________________________________________________________________________________________________________| Page 64 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 4| 0| 2| 4| 0| 0| 4| 4| 2| 4| 4| 2| 2| 2| 2| 4| 2| 2| 0| 7| 7| 7| 7| 7| DAY ON TEST | 9| 6| 9| 8| 6| 4| 9| 6| 6| 8| 6| 6| 8| 8| 8| 8| 6| 8| 8| 9| 3| 3| 3| 3| 3| | 1| 0| 1| 1| 2| 0| 1| 0| 0| 1| 2| 0| 1| 1| 6| 6| 2| 1| 6| 6| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Liver | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 4| 6| 2| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 2| 4| | 9| 9| 9| 3| 0| 0| 0| 0| 0| 0| 0| 8| 5| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + M + + + + + + +| Adenoma | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + M + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Lymphocytic | | Lymphoid Tissue, Lymphoma Malignant | | Mixed | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Hepatocellular Carcinoma | X X X X X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | X X| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + | Odontoma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Bilateral, Subcapsular, Adenoma | X | Subcapsular, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 4| 6| 2| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 2| 4| | 9| 9| 9| 3| 0| 0| 0| 0| 0| 0| 0| 8| 5| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Thymus | + M + + + + + + + + + + M + + + + + + + + M + M +| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M + M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, | | Harderian Gland | | Alveolar/Bronchiolar Adenoma | X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | X| Hepatocellular Carcinoma, Metastatic,| | _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 4| 6| 2| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 2| 4| | 9| 9| 9| 3| 0| 0| 0| 0| 0| 0| 0| 8| 5| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Liver | X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + M + M + M + + + + M + M + + + + + + + + + + M +| Adenocarcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | _____________________________________________________________________________________________________________________| Page 68 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| | | DAY ON TEST | 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| | | | 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + | 78 | Adenoma | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Intestine Large, Cecum | + M + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 79 | Lymphoid Tissue, Lymphoma Malignant | | | Lymphocytic | X | 1 | Lymphoid Tissue, Lymphoma Malignant | | | Mixed | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + | 79 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 80 | Hemangioma | X | 1 | Hepatocellular Carcinoma | X X X | 12 | Hepatocellular Carcinoma, Multiple | X X X | 3 | Hepatocellular Adenoma | X X X X X | 15 | Hepatocellular Adenoma, Multiple | X X X X | 8 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 80 | Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Tooth | + + | 3 | Odontoma | X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 80 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 80 | Adenoma | X | 1 | Bilateral, Subcapsular, Adenoma | | 1 | Subcapsular, Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 79 | Pheochromocytoma Benign | | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 69 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| | | DAY ON TEST | 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| | | | 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 74 | __________________________________________________________________________|____________| Pituitary Gland | + + + M + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 80 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Penis | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + | 45 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 80 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | | 1 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 76 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 80 | Hemangiosarcoma | X | 4 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + M + + M + + | 73 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M + M M M M M M M M M M M M M M | 6 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 80 | Hemangiosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 70 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| | | DAY ON TEST | 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| | | | 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 95 | __________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 95 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 80 | Adenocarcinoma, Metastatic, | | | Harderian Gland | X | 1 | Alveolar/Bronchiolar Adenoma | X X | 7 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Alveolar/Bronchiolar Carcinoma | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X | 6 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 80 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + M M + + + + + + + M + | 71 | Adenocarcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 95 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 71 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 4| 0| 2| 0| 4| 0| 4| 2| 0| 2| 0| 4| 0| 2| DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 6| 9| 8| 9| 6| 9| 6| 8| 9| 8| 9| 6| 9| 8| | 1| 1| 6| 2| 0| 1| 1| 6| 1| 1| 0| 2| 6| 6| 0| 2| 0| 0| 6| 1| 1| 1| 0| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Undifferentiated Cell Type | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Spleen | | Hepatocellular Carcinoma | | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | | Hepatocellular Adenoma, Multiple | | Histiocytic Sarcoma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | Odontoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + +| Bilateral, Subcapsular, Adenoma | | Subcapsular, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 72 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 4| 0| 2| 0| 4| 0| 4| 2| 0| 2| 0| 4| 0| 2| DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 6| 9| 8| 9| 6| 9| 6| 8| 9| 8| 9| 6| 9| 8| | 1| 1| 6| 2| 0| 1| 1| 6| 1| 1| 0| 2| 6| 6| 0| 2| 0| 0| 6| 1| 1| 1| 0| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Preputial Gland | + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Lymph Node | | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | | Pancreatic, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, | | Harderian Gland | | Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M + M M M + M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + +| Fibrosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + +| Meninges, Histiocytic Sarcoma | | __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 73 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 4| 0| 2| 0| 4| 0| 4| 2| 0| 2| 0| 4| 0| 2| DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 6| 9| 8| 9| 6| 9| 6| 8| 9| 8| 9| 6| 9| 8| | 1| 1| 6| 2| 0| 1| 1| 6| 1| 1| 0| 2| 6| 6| 0| 2| 0| 0| 6| 1| 1| 1| 0| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, | | Harderian Gland | | Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Pinna, Fibrosarcoma | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + +| Adenocarcinoma | | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + +| Adenocarcinoma | | Histiocytic Sarcoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 74 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 4| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7| DAY ON TEST | 9| 6| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 9| 8| 3| 3| 3| 3| 3| | 6| 0| 6| 0| 2| 0| 6| 0| 0| 1| 1| 0| 0| 0| 6| 1| 1| 2| 0| 1| 8| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 4| 4| 4| 60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + M M +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Undifferentiated Cell Type | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Spleen | | Hepatocellular Carcinoma | X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X | Histiocytic Sarcoma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | Odontoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + +| Bilateral, Subcapsular, Adenoma | | Subcapsular, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + + M + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 75 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 4| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7| DAY ON TEST | 9| 6| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 9| 8| 3| 3| 3| 3| 3| | 6| 0| 6| 0| 2| 0| 6| 0| 0| 1| 1| 0| 0| 0| 6| 1| 1| 2| 0| 1| 8| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 4| 4| 4| 60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Preputial Gland | + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Lymph Node | | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | | Pancreatic, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + +| Adenocarcinoma, Metastatic, | | Harderian Gland | | Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M + M M M M M M M + M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + +| Meninges, Histiocytic Sarcoma | | __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 76 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 4| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7| DAY ON TEST | 9| 6| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 9| 8| 3| 3| 3| 3| 3| | 6| 0| 6| 0| 2| 0| 6| 0| 0| 1| 1| 0| 0| 0| 6| 1| 1| 2| 0| 1| 8| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 4| 4| 4| 60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, | | Harderian Gland | | Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Pinna, Fibrosarcoma | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + M + M M + + M M M + + + M + + M + +| Adenocarcinoma | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | Histiocytic Sarcoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 77 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| | 8| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 7| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Undifferentiated Cell Type | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Spleen | | Hepatocellular Carcinoma | X X X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X X X X X X| Hepatocellular Adenoma, Multiple | X X X | Histiocytic Sarcoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + + | Odontoma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Subcapsular, Adenoma | X | Subcapsular, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + M + + M + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | Histiocytic Sarcoma | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 78 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| | 8| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 7| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Lymph Node | + | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | X | Pancreatic, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M +| Adenocarcinoma, Metastatic, | | Harderian Gland | X | Histiocytic Sarcoma | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + + + + + M + + + M + + M + + + + + + + M +| Histiocytic Sarcoma | X | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M + M M + + + M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Histiocytic Sarcoma | X | __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 79 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| | 8| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 7| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, | | Harderian Gland | X | Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | X X X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | Pinna, Fibrosarcoma | X | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + + + M + + + + + + + + + + + + + + + + M + +| Adenocarcinoma | X | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Histiocytic Sarcoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 80 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 8| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| | | | 9| 7| 1| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Gallbladder | M M + + + + + + + + + + + + + + + + + + | 77 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 77 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 79 | Lymphoid Tissue, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 79 | Hemangiosarcoma, Metastatic, Spleen | X | 1 | Hepatocellular Carcinoma | X X X X X | 11 | Hepatocellular Carcinoma, Multiple | X X | 2 | Hepatocellular Adenoma | X X | 13 | Hepatocellular Adenoma, Multiple | X X | 6 | Histiocytic Sarcoma | X | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Tooth | + | 3 | Odontoma | X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 79 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 79 | Bilateral, Subcapsular, Adenoma | | 1 | Subcapsular, Adenoma | X X | 2 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + M + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 79 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 81 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 8| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| | | | 9| 7| 1| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | Histiocytic Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 79 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + | 39 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 79 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 79 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node | + | 2 | Mediastinal, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Pancreatic, Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + + + + + + + M + + + + + | 75 | Adenocarcinoma, Metastatic, | | | Harderian Gland | | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + M + + + + + + M + + + + | 76 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Mixed | X X | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 79 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Mixed | X X | 2 | __________________________________________________________________________|____________| Thymus | + + M M + + + + + + + + + + + M + + + + | 72 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Mixed | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M + M M M M M M M + M M | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 82 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 8| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| | | | 9| 7| 1| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 79 | Fibrosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 79 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 79 | Meninges, Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 94 | __________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 94 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 79 | Adenocarcinoma, Metastatic, | | | Harderian Gland | | 1 | Alveolar/Bronchiolar Adenoma | X X X X X | 7 | Alveolar/Bronchiolar Carcinoma | | 4 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X | 6 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 79 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | Pinna, Fibrosarcoma | | 1 | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | M + + + M + + + M + M + + + M + + + M + | 63 | Adenocarcinoma | | 1 | Adenoma | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 79 | Adenocarcinoma | | 1 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 94 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 83 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 8| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| | | | 9| 7| 1| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant Mixed | X X | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 84 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 4| 4| 0| 2| 2| 0| 4| 0| 2| 0| 4| 2| 2| 2| 0| 0| 2| 0| 4| 0| 2| DAY ON TEST | 8| 8| 8| 8| 6| 6| 9| 8| 8| 9| 6| 9| 8| 9| 6| 8| 8| 8| 9| 9| 8| 9| 6| 9| 8| | 1| 1| 1| 6| 0| 0| 0| 1| 1| 1| 0| 1| 1| 6| 0| 6| 1| 6| 1| 6| 1| 6| 2| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 125 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + | Lymphoid Tissue, Lymphoma Malignant | | Lymphocytic | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + | Lymphoid Tissue, Lymphoma Malignant | | Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + | Hemangiosarcoma | | Hemangiosarcoma, Multiple | | Hepatocellular Carcinoma | | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | | Schwannoma Malignant, Metastatic, | | Nose | | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Tooth | | Odontoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + | Adenoma | | Subcapsular, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + | Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + M + + + + + | Schwannoma Malignant, Metastatic, | | Nose | | _____________________________________________________________________________________________________________________| Page 85 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 4| 4| 0| 2| 2| 0| 4| 0| 2| 0| 4| 2| 2| 2| 0| 0| 2| 0| 4| 0| 2| DAY ON TEST | 8| 8| 8| 8| 6| 6| 9| 8| 8| 9| 6| 9| 8| 9| 6| 8| 8| 8| 9| 9| 8| 9| 6| 9| 8| | 1| 1| 1| 6| 0| 0| 0| 1| 1| 1| 0| 1| 1| 6| 0| 6| 1| 6| 1| 6| 1| 6| 2| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 125 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Preputial Gland | + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Lymph Node | | Lumbar, Lymphoma Malignant | | Lymphocytic | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + | Hemangiosarcoma | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M + M M M M | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + | Schwannoma Malignant, Metastatic, | | Nose | | __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + | Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Adenoma, | | _____________________________________________________________________________________________________________________| Page 86 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 4| 4| 0| 2| 2| 0| 4| 0| 2| 0| 4| 2| 2| 2| 0| 0| 2| 0| 4| 0| 2| DAY ON TEST | 8| 8| 8| 8| 6| 6| 9| 8| 8| 9| 6| 9| 8| 9| 6| 8| 8| 8| 9| 9| 8| 9| 6| 9| 8| | 1| 1| 1| 6| 0| 0| 0| 1| 1| 1| 0| 1| 1| 6| 0| 6| 1| 6| 1| 6| 1| 6| 2| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 125 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Multiple | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + | Schwannoma Malignant | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + | Adenocarcinoma | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 87 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 0| 2| 4| 2| 4| 0| 4| 7| 7| 7| 7| 6| DAY ON TEST | 9| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 9| 8| 6| 8| 6| 9| 6| 3| 3| 3| 3| 6| | 0| 1| 2| 0| 0| 6| 0| 2| 1| 0| 0| 1| 2| 0| 1| 0| 6| 0| 0| 2| 7| 7| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 125 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 9| 9| 9| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Lymphocytic | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hemangiosarcoma, Multiple | X | Hepatocellular Carcinoma | X X| Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X X | Schwannoma Malignant, Metastatic, | | Nose | X| __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | Odontoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + +| Adenoma | X | Subcapsular, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + M + + + + + + + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Nose | X| _____________________________________________________________________________________________________________________| Page 88 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 0| 2| 4| 2| 4| 0| 4| 7| 7| 7| 7| 6| DAY ON TEST | 9| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 9| 8| 6| 8| 6| 9| 6| 3| 3| 3| 3| 6| | 0| 1| 2| 0| 0| 6| 0| 2| 1| 0| 0| 1| 2| 0| 1| 0| 6| 0| 0| 2| 7| 7| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 125 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 9| 9| 9| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | Lumbar, Lymphoma Malignant | | Lymphocytic | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | __________________________________________________________________________| Thymus | + + + + + + + + + + + I + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M + M M M M M + M M + M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Nose | X| __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Adenoma, | | _____________________________________________________________________________________________________________________| Page 89 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 0| 2| 4| 2| 4| 0| 4| 7| 7| 7| 7| 6| DAY ON TEST | 9| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 9| 8| 6| 8| 6| 9| 6| 3| 3| 3| 3| 6| | 0| 1| 2| 0| 0| 6| 0| 2| 1| 0| 0| 1| 2| 0| 1| 0| 6| 0| 0| 2| 7| 7| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 125 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 9| 9| 9| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Multiple | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant | X| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + I + + M + + M +| Adenocarcinoma | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 90 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 9| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 7| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Lymphocytic | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Lymphoma Malignant | | Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hemangiosarcoma, Multiple | | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X X X | Schwannoma Malignant, Metastatic, | | Nose | | __________________________________________________________________________| Mesentery | +| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + | Odontoma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Subcapsular, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + M + M + + + + + M + + + + + + + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | M + + + + + + + M + + + + + + + + M + + + + + + +| Schwannoma Malignant, Metastatic, | | Nose | | _____________________________________________________________________________________________________________________| Page 91 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 9| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 7| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Lumbar, Lymphoma Malignant | | Lymphocytic | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + M + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Thymus | + + M + + + M + + + + + + + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M + M M M M M + M M + M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Nose | | __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X | Alveolar/Bronchiolar Adenoma, | | _____________________________________________________________________________________________________________________| Page 92 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 9| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 7| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Multiple | | Alveolar/Bronchiolar Carcinoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + M M + M + M + + + M M + + + M + + + + + + + + +| Adenocarcinoma | X | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 93 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 2| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 8| 8| 8| 8| 4| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + | 76 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + | 79 | Lymphoid Tissue, Lymphoma Malignant | | | Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + | 79 | Lymphoid Tissue, Lymphoma Malignant | | | Mixed | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + | 79 | Hemangiosarcoma | X | 2 | Hemangiosarcoma, Multiple | | 1 | Hepatocellular Carcinoma | X X X | 8 | Hepatocellular Carcinoma, Multiple | | 2 | Hepatocellular Adenoma | X X X X | 11 | Hepatocellular Adenoma, Multiple | X X X | 8 | Schwannoma Malignant, Metastatic, | | | Nose | | 1 | __________________________________________________________________________|____________| Mesentery | + | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + | 79 | Squamous Cell Papilloma | X X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Tooth | + | 2 | Odontoma | X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + | 79 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + | 79 | Adenoma | | 1 | Subcapsular, Adenoma | X | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 94 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 2| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 8| 8| 8| 8| 4| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Adenoma | X | 3 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + M + + M + + + | 71 | __________________________________________________________________________|____________| Pituitary Gland | + M + + + + + + + + + + + + + + + + + | 74 | Schwannoma Malignant, Metastatic, | | | Nose | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + | 79 | Follicular Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + | 46 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + | 79 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Lymph Node | | 1 | Lumbar, Lymphoma Malignant | | | Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + M M + + + M + + + + + + + + | 73 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + | 76 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + | 79 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + M + + + + + + + + + + + + | 74 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M + M M M M + M M M M M M | 9 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + | 79 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + | 79 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 95 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 2| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 8| 8| 8| 8| 4| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + | 79 | Schwannoma Malignant, Metastatic, | | | Nose | | 1 | __________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + | 94 | __________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + | 94 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + | 79 | Alveolar/Bronchiolar Adenoma | X X X | 10 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X X | 2 | Alveolar/Bronchiolar Carcinoma | | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 4 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + | 79 | Schwannoma Malignant | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + | 79 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | M + + M + + + + + + + M + + + + + + + | 66 | Adenocarcinoma | X | 2 | Adenoma | X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + | 94 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 96 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 4| 2| 0| 2| 0| 2| 0| 4| 0| 0| 2| 4| 4| 2| 0| 0| 2| 0| 4| 2| 0| DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 9| 8| 9| 6| 9| 9| 8| 6| 6| 8| 9| 9| 8| 9| 6| 8| 9| | 1| 1| 6| 2| 0| 1| 1| 6| 0| 1| 0| 2| 6| 0| 6| 2| 0| 6| 0| 1| 1| 1| 0| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Gallbladder | + + + + + + + + + M + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + | Adenocarcinoma | | Lymphoid Tissue, Lymphoma Malignant | | Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + | Hepatocellular Carcinoma | | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | | Hepatocellular Adenoma, Multiple | | Histiocytic Sarcoma | | Ito Cell Tumor Benign | | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Tooth | | Odontoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + | Hemangiosarcoma, Metastatic, Bone | | Marrow | | Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + | Adenoma | | Subcapsular, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + | Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Pituitary Gland | + + + + M + + + + + + + + + + + | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 97 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 4| 2| 0| 2| 0| 2| 0| 4| 0| 0| 2| 4| 4| 2| 0| 0| 2| 0| 4| 2| 0| DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 9| 8| 9| 6| 9| 9| 8| 6| 6| 8| 9| 9| 8| 9| 6| 8| 9| | 1| 1| 6| 2| 0| 1| 1| 6| 0| 1| 0| 2| 6| 0| 6| 2| 0| 6| 0| 1| 1| 1| 0| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + | Histiocytic Sarcoma | | __________________________________________________________________________| Preputial Gland | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + | Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + | Hemangiosarcoma | | Mast Cell Tumor Malignant | | Sarcoma, Metastatic, Bone | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + M + | __________________________________________________________________________| Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + | Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + | Hemangiosarcoma | | Histiocytic Sarcoma | | Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + | Hemangiosarcoma, Metastatic, Bone | | Marrow | | Femur, Sarcoma | | __________________________________________________________________________| Skeletal Muscle | | Hemangiosarcoma, Metastatic, Bone | | Marrow | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 98 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 4| 2| 0| 2| 0| 2| 0| 4| 0| 0| 2| 4| 4| 2| 0| 0| 2| 0| 4| 2| 0| DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 9| 8| 9| 6| 9| 9| 8| 6| 6| 8| 9| 9| 8| 9| 6| 8| 9| | 1| 1| 6| 2| 0| 1| 1| 6| 0| 1| 0| 2| 6| 0| 6| 2| 0| 6| 0| 1| 1| 1| 0| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + | Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + | Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Pinna, Fibrosarcoma | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | M + + + + + + + M M + + + + + + | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + | Histiocytic Sarcoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 99 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 4| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7| DAY ON TEST | 9| 6| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 9| 8| 3| 3| 3| 3| 3| | 6| 0| 6| 0| 2| 0| 6| 0| 0| 1| 0| 0| 1| 0| 6| 1| 1| 2| 1| 1| 6| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + M + + + + M + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X| Lymphoid Tissue, Lymphoma Malignant | | Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X| Hepatocellular Adenoma, Multiple | | Histiocytic Sarcoma | | Ito Cell Tumor Benign | | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | Odontoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Bone | | Marrow | | Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + +| Adenoma | X | Subcapsular, Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + M + + M + + + + + + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 100 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 4| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7| DAY ON TEST | 9| 6| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 9| 8| 3| 3| 3| 3| 3| | 6| 0| 6| 0| 2| 0| 6| 0| 0| 1| 0| 0| 1| 0| 6| 1| 1| 2| 1| 1| 6| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Preputial Gland | + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Mast Cell Tumor Malignant | | Sarcoma, Metastatic, Bone | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | | Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + M + M M M + M + M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Bone | | Marrow | | Femur, Sarcoma | | __________________________________________________________________________| Skeletal Muscle | | Hemangiosarcoma, Metastatic, Bone | | Marrow | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 101 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 0| 4| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7| DAY ON TEST | 9| 6| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 9| 8| 3| 3| 3| 3| 3| | 6| 0| 6| 0| 2| 0| 6| 0| 0| 1| 0| 0| 1| 0| 6| 1| 1| 2| 1| 1| 6| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + +| Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Pinna, Fibrosarcoma | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | M + + M + M + + + M + + + + + + + + +| Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 102 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| | 6| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 250 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Lymphoid Tissue, Lymphoma Malignant | | Mixed | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X X X X | Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X X X X X X X | Hepatocellular Adenoma, Multiple | X X X | Histiocytic Sarcoma | | Ito Cell Tumor Benign | | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | Odontoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Bone | | Marrow | X | Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Subcapsular, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + M + + + + + + + + + + + M + M + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 103 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| | 6| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 250 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Mast Cell Tumor Malignant | X | Sarcoma, Metastatic, Bone | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + M M + + + + M + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | M + + + M + + + + + + + + + + + + + + + M + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + M + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | | Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + M + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M + M M +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Bone | | Marrow | X | Femur, Sarcoma | X | __________________________________________________________________________| Skeletal Muscle | + | Hemangiosarcoma, Metastatic, Bone | | Marrow | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 104 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| | 6| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 250 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X X| Alveolar/Bronchiolar Carcinoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Pinna, Fibrosarcoma | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + + + + + M + + + + + + + + M + + + + M + M + M +| Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 105 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 7| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| | | | 6| 6| 8| 6| 7| 6| 6| 6| 6| 6| 6| 7| 2| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Gallbladder | + + + + M + + + + + + + + + + + + + + + | 75 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + | 79 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 80 | Adenocarcinoma | | 2 | Lymphoid Tissue, Lymphoma Malignant | | | Mixed | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 80 | Hepatocellular Carcinoma | X X X | 12 | Hepatocellular Carcinoma, Multiple | X | 3 | Hepatocellular Adenoma | X X X | 13 | Hepatocellular Adenoma, Multiple | X X X X | 7 | Histiocytic Sarcoma | X X | 2 | Ito Cell Tumor Benign | X | 1 | __________________________________________________________________________|____________| Mesentery | + | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Tooth | + | 1 | Odontoma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 80 | Hemangiosarcoma, Metastatic, Bone | | | Marrow | | 1 | Histiocytic Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 80 | Adenoma | | 1 | Subcapsular, Adenoma | X | 2 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 78 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 80 | Adenoma | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 106 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 7| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| | | | 6| 6| 8| 6| 7| 6| 6| 6| 6| 6| 6| 7| 2| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + + M + M + + M + + + + | 72 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + M + + + + + + + + + | 74 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 80 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 80 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + | 45 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 80 | Interstitial Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 | Hemangiosarcoma | | 1 | Mast Cell Tumor Malignant | | 1 | Sarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + | 75 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 76 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 79 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | X X | 2 | Mast Cell Tumor Malignant, | | | Metastatic, Bone Marrow | | 1 | __________________________________________________________________________|____________| Thymus | + + M + + + + + M + + + + + + + M + + + | 75 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M + M M M M + M M M M M M M M M M M M | 8 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 80 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 107 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 7| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| | | | 6| 6| 8| 6| 7| 6| 6| 6| 6| 6| 6| 7| 2| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 80 | Hemangiosarcoma, Metastatic, Bone | | | Marrow | | 1 | Femur, Sarcoma | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Hemangiosarcoma, Metastatic, Bone | | | Marrow | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 80 | __________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 95 | __________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 95 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 80 | Alveolar/Bronchiolar Adenoma | X X X X | 10 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 2 | Alveolar/Bronchiolar Carcinoma | | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 2 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 80 | Mast Cell Tumor Malignant, | | | Metastatic, Bone Marrow | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 80 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | Pinna, Fibrosarcoma | X | 1 | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | + M + + + + + + M + + M M + + M M + M M | 60 | Adenoma | X X X | 5 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 80 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + M + + + + + + | 79 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 108 NTP Experiment-Test: 05100-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/02/97 Route: DOSED FEED Time: 13:15:02 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 7| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| | | | 6| 6| 8| 6| 7| 6| 6| 6| 6| 6| 6| 7| 2| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 95 | Histiocytic Sarcoma | X X | 2 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 109 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------