TDMS Study 05100-04 Pathology Tables
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:17
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1330-78-5
Lock Date: 12/13/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 95 95 95 95
Scheduled Sacrifice 45 45 45 44
Early Deaths
Natural Death 5 7 2 3
Moribund Sacrifice 4 5 4 3
Survivors
Natural Death 1 1
Terminal Sacrifice 40 37 42 45
Missing 2
Animals Examined Microscopically 95 95 93 95
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (79) (78) (77) (80)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%)
Intestine Large, Rectum (80) (78) (78) (80)
Osteosarcoma, Metastatic, Bone 1 (1%)
Intestine Small, Jejunum (79) (80) (78) (80)
Liver (80) (80) (78) (80)
Hemangiosarcoma, Metastatic, Spleen 1 (1%)
Hepatocellular Carcinoma 9 (11%) 2 (3%) 1 (1%) 5 (6%)
Hepatocellular Carcinoma, Multiple 1 (1%) 1 (1%) 1 (1%)
Hepatocellular Adenoma 8 (10%) 12 (15%) 10 (13%) 8 (10%)
Hepatocellular Adenoma, Multiple 5 (6%) 1 (1%) 3 (4%) 8 (10%)
Hepatocholangiocarcinoma 1 (1%)
Histiocytic Sarcoma 2 (3%) 1 (1%)
Mesentery (6) (5) (6) (3)
Fibrosarcoma, Metastatic, Skin 1 (17%) 1 (20%)
Pancreas (80) (80) (78) (80)
Salivary Glands (79) (80) (78) (80)
Stomach, Forestomach (80) (80) (78) (80)
Squamous Cell Papilloma 1 (1%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (80) (80) (78) (80)
Hemangiosarcoma 1 (1%)
Histiocytic Sarcoma 1 (1%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (80) (79) (78) (80)
Adenoma 1 (1%) 1 (1%)
Subcapsular, Adenoma 3 (4%)
Adrenal Medulla (80) (79) (78) (78)
Pheochromocytoma Benign 2 (3%) 1 (1%)
Islets, Pancreatic (80) (80) (78) (80)
Carcinoma 1 (1%)
Parathyroid Gland (71) (67) (66) (67)
Pituitary Gland (76) (76) (76) (79)
Pars Distalis, Adenoma 6 (8%) 8 (11%) 6 (8%) 9 (11%)
Pars Intermedia, Adenoma 1 (1%) 2 (3%)
Thyroid Gland (79) (80) (78) (80)
Follicular Cell, Adenoma 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Leiomyoma 1 (100%)
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GENITAL SYSTEM
Ovary (78) (80) (77) (79)
Cystadenoma 1 (1%) 2 (3%)
Fibrous Histiocytoma 1 (1%)
Granulosa Cell Tumor Malignant 1 (1%)
Hemangioma 1 (1%)
Histiocytic Sarcoma 1 (1%)
Luteoma 1 (1%)
Teratoma NOS 1 (1%)
Uterus (80) (80) (78) (80)
Hemangioma 1 (1%)
Histiocytic Sarcoma 1 (1%) 2 (3%) 1 (1%) 1 (1%)
Polyp Stromal 1 (1%) 1 (1%) 3 (4%)
Polyp Stromal, Multiple 1 (1%)
Serosa, Fibrosarcoma, Metastatic, Skin 1 (1%)
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HEMATOPOIETIC SYSTEM
Blood (1)
Bone Marrow (80) (80) (78) (80)
Osteosarcoma, Metastatic, Bone 1 (1%)
Sarcoma 1 (1%)
Lymph Node (3) (4) (3)
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NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Lumbar, Renal, Thoracic, Iliac, Bronchial,
Mediastinal, Lymphoma Malignant Mixed 1 (33%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (33%)
Mediastinal, Histiocytic Sarcoma 1 (25%)
Pancreatic, Hepatocholangiocarcinoma,
Metastatic, Liver 1 (25%)
Renal, Histiocytic Sarcoma 1 (33%)
Lymph Node, Mandibular (75) (77) (78) (76)
Histiocytic Sarcoma 1 (1%) 1 (1%)
Lymph Node, Mesenteric (78) (75) (75) (78)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (1%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%)
Histiocytic Sarcoma 2 (3%) 1 (1%)
Spleen (80) (80) (78) (80)
Hemangioma 1 (1%)
Hemangiosarcoma 3 (4%) 1 (1%) 1 (1%) 1 (1%)
Histiocytic Sarcoma 2 (3%) 2 (3%)
Thymus (75) (74) (77) (74)
Histiocytic Sarcoma 1 (1%)
Thymoma Malignant 1 (1%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (79) (79) (75) (80)
Adenocarcinoma 1 (1%)
Skin (80) (80) (78) (80)
Fibrosarcoma 2 (3%) 1 (1%) 1 (1%)
Hemangioma 1 (1%)
Sarcoma 1 (1%)
Subcutaneous Tissue, Myxosarcoma 1 (1%)
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MUSCULOSKELETAL SYSTEM
Bone (80) (80) (78) (80)
Vertebra, Osteosarcoma 1 (1%)
Skeletal Muscle (2) (1)
Fibrosarcoma, Multiple, Metastatic, Skin 1 (50%)
Sarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (80) (80) (78) (80)
Meninges, Myxosarcoma, Metastatic, Skin 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (80) (80) (78) (80)
Adenocarcinoma, Metastatic, Harderian Gland 1 (1%)
Alveolar/Bronchiolar Adenoma 2 (3%) 4 (5%) 3 (4%) 5 (6%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (1%)
Alveolar/Bronchiolar Carcinoma 3 (4%) 1 (1%) 2 (3%) 1 (1%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (1%)
Fibrosarcoma, Metastatic, Skin 2 (3%)
Hepatocellular Carcinoma, Metastatic, Liver 5 (6%) 1 (1%) 1 (1%) 2 (3%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%)
Histiocytic Sarcoma 2 (3%) 1 (1%)
Osteosarcoma, Multiple, Metastatic, Bone 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2)
Pinna, Fibrosarcoma 1 (50%)
Harderian Gland (70) (60) (51) (60)
Adenocarcinoma 1 (2%)
Adenoma 5 (7%) 3 (5%)
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URINARY SYSTEM
Kidney (80) (80) (78) (80)
Renal Tubule, Adenoma 1 (1%)
Urinary Bladder (79) (80) (77) (80)
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SYSTEMIC LESIONS
Multiple Organs *(95) *(95) *(93) *(95)
Histiocytic Sarcoma 1 (1%) 3 (3%) 2 (2%) 1 (1%)
Leukemia Lymphocytic 1 (1%)
Lymphoma Malignant Lymphocytic 3 (3%) 3 (3%) 3 (3%)
Lymphoma Malignant Mixed 3 (3%) 2 (2%) 3 (3%)
Lymphoma Malignant Undifferentiated Cell 1 (1%) 3 (3%) 1 (1%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 41 41 33 42
Total Primary Neoplasms 66 49 49 56
Total Animals with Benign Neoplasms 28 31 25 32
Total Benign Neoplasms 37 32 33 35
Total Animals with Malignant Neoplasms 22 16 15 19
Total Malignant Neoplasms 28 17 16 21
Total Animals with Metastatic Neoplasms 9 5 1 3
Total Metastatic Neoplasm 13 8 1 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 95 95 95 95
Scheduled Sacrifice 43 45 45 45
Early Deaths
Moribund Sacrifice 4 1 1 2
Accidently Killed 1
Natural Death 4 5 4 6
Survivors
Terminal Sacrifice 43 43 44 42
Missing 1 1
Animals Examined Microscopically 95 94 94 95
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (78) (77) (76) (75)
Adenoma 1 (1%)
Intestine Large, Colon (80) (78) (79) (80)
Intestine Small, Jejunum (79) (79) (79) (80)
Adenocarcinoma 2 (3%)
Liver (80) (79) (79) (80)
Hemangioma 1 (1%)
Hemangiosarcoma 2 (3%)
Hemangiosarcoma, Multiple 1 (1%)
Hemangiosarcoma, Metastatic, Spleen 1 (1%)
Hepatocellular Carcinoma 12 (15%) 11 (14%) 8 (10%) 12 (15%)
Hepatocellular Carcinoma, Multiple 3 (4%) 2 (3%) 2 (3%) 3 (4%)
Hepatocellular Adenoma 15 (19%) 13 (16%) 11 (14%) 13 (16%)
Hepatocellular Adenoma, Multiple 8 (10%) 6 (8%) 8 (10%) 7 (9%)
Histiocytic Sarcoma 2 (3%) 2 (3%)
Ito Cell Tumor Benign 1 (1%)
Schwannoma Malignant, Metastatic, Nose 1 (1%)
Stomach, Forestomach (80) (79) (79) (80)
Squamous Cell Carcinoma 1 (1%)
Squamous Cell Papilloma 2 (3%)
Tooth (3) (3) (2) (1)
Odontoma 2 (67%) 2 (67%) 2 (100%) 1 (100%)
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NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (80) (79) (79) (80)
Hemangiosarcoma 1 (1%)
Hemangiosarcoma, Metastatic, Bone Marrow 1 (1%)
Histiocytic Sarcoma 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (80) (79) (79) (80)
Adenoma 1 (1%) 1 (1%) 1 (1%)
Bilateral, Subcapsular, Adenoma 1 (1%) 1 (1%)
Subcapsular, Adenoma 1 (1%) 2 (3%) 1 (1%) 2 (3%)
Adrenal Medulla (79) (79) (79) (78)
Pheochromocytoma Benign 2 (3%)
Islets, Pancreatic (80) (79) (79) (80)
Adenoma 1 (1%) 3 (4%) 2 (3%)
Pituitary Gland (78) (79) (74) (74)
Schwannoma Malignant, Metastatic, Nose 1 (1%)
Thyroid Gland (80) (79) (79) (80)
Follicular Cell, Adenoma 2 (3%) 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
Histiocytic Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (80) (79) (79) (80)
Histiocytic Sarcoma 1 (1%) 1 (1%)
Testes (80) (79) (79) (80)
Interstitial Cell, Adenoma 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (80) (79) (79) (80)
Hemangiosarcoma 1 (1%)
Histiocytic Sarcoma 1 (1%)
Mast Cell Tumor Malignant 1 (1%)
Sarcoma, Metastatic, Bone 1 (1%)
Lymph Node (1) (2) (1)
Lymph Node, Mandibular (78) (75) (73) (75)
Adenocarcinoma, Metastatic, Harderian Gland 1 (1%)
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NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Histiocytic Sarcoma 1 (1%)
Lymph Node, Mesenteric (76) (76) (76) (76)
Histiocytic Sarcoma 1 (1%) 1 (1%)
Spleen (80) (79) (79) (79)
Hemangiosarcoma 4 (5%) 1 (1%) 1 (1%) 1 (1%)
Histiocytic Sarcoma 1 (1%) 2 (3%)
Mast Cell Tumor Malignant, Metastatic, Bone
Marrow 1 (1%)
Thymus (73) (72) (74) (75)
Histiocytic Sarcoma 1 (1%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (80) (79) (79) (80)
Fibrosarcoma 1 (1%)
Hemangiosarcoma 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (80) (79) (79) (80)
Hemangiosarcoma, Metastatic, Bone Marrow 1 (1%)
Femur, Sarcoma 1 (1%)
Skeletal Muscle (1) (1)
Hemangiosarcoma, Metastatic, Bone Marrow 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (80) (79) (79) (80)
Schwannoma Malignant, Metastatic, Nose 1 (1%)
Meninges, Histiocytic Sarcoma 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (80) (79) (79) (80)
Adenocarcinoma, Metastatic, Harderian Gland 1 (1%) 1 (1%)
Alveolar/Bronchiolar Adenoma 7 (9%) 7 (9%) 10 (13%) 10 (13%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (1%) 2 (3%) 2 (3%)
Alveolar/Bronchiolar Carcinoma 1 (1%) 4 (5%) 2 (3%) 2 (3%)
Hepatocellular Carcinoma, Metastatic, Liver 6 (8%) 6 (8%) 4 (5%) 2 (3%)
Histiocytic Sarcoma 1 (1%) 1 (1%)
Nose (80) (79) (79) (80)
Mast Cell Tumor Malignant, Metastatic, Bone
Marrow 1 (1%)
Page 9
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Schwannoma Malignant 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1)
Pinna, Fibrosarcoma 1 (100%) 1 (100%)
Harderian Gland (71) (63) (66) (60)
Adenocarcinoma 1 (1%) 1 (2%) 2 (3%)
Adenoma 2 (3%) 2 (3%) 5 (8%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (80) (79) (79) (80)
Adenocarcinoma 1 (1%)
Histiocytic Sarcoma 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(95) *(94) *(94) *(95)
Histiocytic Sarcoma 2 (2%) 2 (2%)
Lymphoma Malignant Lymphocytic 1 (1%) 1 (1%)
Lymphoma Malignant Mixed 2 (2%) 2 (2%) 1 (1%) 1 (1%)
Lymphoma Malignant Undifferentiated Cell 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05100-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 14:29:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 60 PPM 125 PPM 250 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 44 38 42 42
Total Primary Neoplasms 67 61 65 74
Total Animals with Benign Neoplasms 33 24 35 35
Total Benign Neoplasms 41 33 44 46
Total Animals with Malignant Neoplasms 22 23 17 21
Total Malignant Neoplasms 26 28 21 28
Total Animals with Metastatic Neoplasms 6 8 5 5
Total Metastatic Neoplasm 7 9 7 8
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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