TDMS Study 05100-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Battelle Columbus TRICRESYL PHOSPHATE DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 TIME: 16:08:19 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: N01ES45050 ROUTE: DOSED FEED NTP C#: 61041B PATHOLOGIST: A. SINGER CAS: 1330-78-5 ------------------------------------------------------------------------------------------------------------------------------------ REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Battelle Columbus TRICRESYL PHOSPHATE DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 TIME: 16:08:19 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01ES45050 ROUTE: DOSED FEED NTP C#: 61041B PATHOLOGIST: A. SINGER CAS: 1330-78-5 MICE(B6C3F1) ---------------------------- FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED. IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED. ---------------- Adrenal Cortex Adrenal Medulla Bone Marrow Brain Clitoral Gland Epididymis Gallbladder Heart Islets, Pancreatic Kidney Liver Lung Nose Ovary Pancreas Parathyroid Gland Pituitary Gland Preputial Gland Prostate Salivary Glands Spleen Testes Thymus Thyroid Gland Urinary Bladder NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Battelle Columbus TRICRESYL PHOSPHATE DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 TIME: 16:08:19 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01ES45050 ROUTE: DOSED FEED NTP C#: 61041B PATHOLOGIST: A. SINGER CAS: 1330-78-5 SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS IN THE ANALYSIS OF THE STUDY OF TRICRESYL PHOSPHATE ==================================================================================================== MALE MICE ------------- ORGAN MORPHOLOGY ------- ------------ Harderian Gland Adenoma Intestine Small: Jejunum Carcinoma Intestine Small: Site Unspecified Carcinoma ==================================================================================================== FEMALE MICE ------------- ORGAN MORPHOLOGY ------- ------------ Harderian Gland Adenoma Carcinoma or Adenoma Liver Hepatocellular Carcinoma ==================================================================================================== DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 1 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |Adrenal Cortex | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/80 (4%) 3/79 (4%) 2/79 (3%) 3/80 (4%) | 4/80 (5%) 0/79 (0%) 0/78 (0%) 1/80 (1%) | |ADJUSTED (b) | 6.3% 7.0% 3.9% 6.4% | 8.9% 0.0% 0.0% 2.1% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 1/10 (10%) 0/10 (0%) 1/10 (10%) 1/10 (10%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 2/43 (5%) 3/43 (7%) 1/44 (2%) 2/42 (5%) | 3/41 (7%) 0/38 (0%) 0/42 (0%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | 460 (I) 736 (T) 460 (I) 460 (I) | 461 (I) --- --- 555 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.569N P=0.661 P=0.494N P=0.654 | P=0.123N P=0.072N P=0.063N P=0.172N | |INCIDENTAL TUMOR | P=0.569N P=0.661 P=0.494N P=0.654 | P=0.102N P=0.072N P=0.063N P=0.116N | |LOGISTIC REGRESSION | P=0.560N P=0.660N P=0.500N P=0.662N | P=0.129N P=0.068N P=0.066N P=0.180N | |COCHRAN-ARMITAGE | P=0.559N | P=0.131N | |FISHER EXACT | P=0.653 P=0.506N P=0.659N | P=0.062N P=0.063N P=0.184N | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma Benign | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/79 (3%) 0/79 (0%) 0/79 (0%) 0/78 (0%) | 2/80 (3%) 0/79 (0%) 1/78 (1%) 0/78 (0%) | |ADJUSTED (b) | 4.7% 0.0% 0.0% 0.0% | 4.9% 0.0% 2.2% 0.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | |TERMINAL (d) | 2/43 (5%) 0/43 (0%) 0/44 (0%) 0/41 (0%) | 2/41 (5%) 0/38 (0%) 0/42 (0%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | 736 (T) --- --- --- | 736 (T) --- 621 --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.120N P=0.238N P=0.233N P=0.249N | P=0.181N P=0.255N P=0.494N P=0.218N | |INCIDENTAL TUMOR | P=0.120N P=0.238N P=0.233N P=0.249N | P=0.146N P=0.255N P=0.416N P=0.218N | |LOGISTIC REGRESSION | P=0.120N P=0.238N P=0.233N P=0.249N | P=0.190N P=0.255N P=0.504N P=0.218N | |COCHRAN-ARMITAGE | P=0.119N | P=0.197N | |FISHER EXACT | P=0.248N P=0.248N P=0.252N | P=0.252N P=0.510N P=0.255N | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 2 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |Harderian Gland | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 0/80 (0%) 2/79 (3%) 2/79 (3%) 5/80 (6%) | 5/80 (6%) 3/80 (4%) 0/78 (0%) 0/80 (0%) | |ADJUSTED (b) | 0.0% 4.0% 4.5% 11.9% | 12.2% 7.3% 0.0% 0.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 0/43 (0%) 1/43 (2%) 2/44 (5%) 5/42 (12%) | 5/41 (12%) 2/38 (5%) 0/42 (0%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | --- 460 (I) 736 (T) 736 (T) | 736 (T) 603 --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.016 * P=0.240 P=0.244 P=0.031 * | P=0.006N** P=0.394N P=0.031N* P=0.026N* | |INCIDENTAL TUMOR | P=0.016 * P=0.240 P=0.244 P=0.031 * | P=0.005N** P=0.323N P=0.031N* P=0.026N* | |LOGISTIC REGRESSION | P=0.017 * P=0.237 P=0.244 P=0.031 * | P=0.007N** P=0.377N P=0.031N* P=0.026N* | |COCHRAN-ARMITAGE | P=0.018 * | P=0.008N** | |FISHER EXACT | P=0.245 P=0.245 P=0.029 * | P=0.360N P=0.031N* P=0.029N* | |=================================================================================================================================| | | |Harderian Gland | | Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 1/80 (1%) 1/79 (1%) 2/79 (3%) 0/80 (0%) | 0/80 (0%) 0/80 (0%) 1/78 (1%) 0/80 (0%) | |ADJUSTED (b) | 2.3% 2.3% 4.5% 0.0% | 0.0% 0.0% 2.3% 0.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 1/43 (2%) 1/43 (2%) 2/44 (5%) 0/42 (0%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 736 (T) --- | --- --- 723 --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.372N P=0.762 P=0.508 P=0.505N | P=0.706 (e) P=0.514 (e) | |INCIDENTAL TUMOR | P=0.372N P=0.762 P=0.508 P=0.505N | P=0.517 (e) P=0.398 (e) | |LOGISTIC REGRESSION | P=0.372N P=0.762 P=0.508 P=0.505N | P=0.696 (e) P=0.501 (e) | |COCHRAN-ARMITAGE | P=0.367N | P=0.690 | |FISHER EXACT | P=0.748 P=0.495 P=0.500N | (e) P=0.494 (e) | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 3 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |Harderian Gland | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 1/80 (1%) 3/79 (4%) 3/79 (4%) 5/80 (6%) | 5/80 (6%) 3/80 (4%) 1/78 (1%) 0/80 (0%) | |ADJUSTED (b) | 2.3% 6.3% 6.8% 11.9% | 12.2% 7.3% 2.3% 0.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 1/43 (2%) 2/43 (5%) 3/44 (7%) 5/42 (12%) | 5/41 (12%) 2/38 (5%) 0/42 (0%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | 736 (T) 460 (I) 736 (T) 736 (T) | 736 (T) 603 723 --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.076 P=0.307 P=0.314 P=0.098 | P=0.010N* P=0.394N P=0.098N P=0.026N* | |INCIDENTAL TUMOR | P=0.076 P=0.307 P=0.314 P=0.098 | P=0.011N* P=0.323N P=0.119N P=0.026N* | |LOGISTIC REGRESSION | P=0.081 P=0.306 P=0.314 P=0.098 | P=0.011N* P=0.377N P=0.098N P=0.026N* | |COCHRAN-ARMITAGE | P=0.084 | P=0.013N* | |FISHER EXACT | P=0.305 P=0.305 P=0.105 | P=0.360N P=0.111N P=0.029N* | |=================================================================================================================================| | | |Intestine Small: Jejunum | | Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 0/80 (0%) 0/79 (0%) 0/79 (0%) 2/80 (3%) | 0/80 (0%) 0/80 (0%) 0/78 (0%) 0/80 (0%) | |ADJUSTED (b) | 0.0% 0.0% 0.0% 4.8% | 0.0% 0.0% 0.0% 0.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 0/43 (0%) 0/43 (0%) 0/44 (0%) 2/42 (5%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | --- --- --- 736 (T) | --- --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.044 * (e) (e) P=0.233 | (e) (e) (e) (e) | |INCIDENTAL TUMOR | P=0.044 * (e) (e) P=0.233 | (e) (e) (e) (e) | |LOGISTIC REGRESSION | P=0.044 * (e) (e) P=0.233 | (e) (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.047 * | (e) | |FISHER EXACT | (e) (e) P=0.248 | (e) (e) (e) | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 4 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |Intestine Small: Site Unspecified | | Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 0/80 (0%) 0/79 (0%) 0/79 (0%) 2/80 (3%) | 0/80 (0%) 0/80 (0%) 0/78 (0%) 0/80 (0%) | |ADJUSTED (b) | 0.0% 0.0% 0.0% 4.8% | 0.0% 0.0% 0.0% 0.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 0/43 (0%) 0/43 (0%) 0/44 (0%) 2/42 (5%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | --- --- --- 736 (T) | --- --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.044 * (e) (e) P=0.233 | (e) (e) (e) (e) | |INCIDENTAL TUMOR | P=0.044 * (e) (e) P=0.233 | (e) (e) (e) (e) | |LOGISTIC REGRESSION | P=0.044 * (e) (e) P=0.233 | (e) (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.047 * | (e) | |FISHER EXACT | (e) (e) P=0.248 | (e) (e) (e) | |=================================================================================================================================| | | |Islets, Pancreatic | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/80 (1%) 0/79 (0%) 3/79 (4%) 2/80 (3%) | 0/80 (0%) 0/80 (0%) 0/78 (0%) 0/80 (0%) | |ADJUSTED (b) | 2.3% 0.0% 6.5% 4.8% | 0.0% 0.0% 0.0% 0.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 1/43 (2%) 0/43 (0%) 2/44 (5%) 2/42 (5%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | 736 (T) --- 583 736 (T) | --- --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.231 P=0.500N P=0.315 P=0.492 | (e) (e) (e) (e) | |INCIDENTAL TUMOR | P=0.172 P=0.500N P=0.236 P=0.492 | (e) (e) (e) (e) | |LOGISTIC REGRESSION | P=0.238 P=0.500N P=0.312 P=0.492 | (e) (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.240 | (e) | |FISHER EXACT | P=0.503N P=0.305 P=0.500 | (e) (e) (e) | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 5 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |Islets, Pancreatic | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/80 (1%) 0/79 (0%) 3/79 (4%) 2/80 (3%) | 1/80 (1%) 0/80 (0%) 0/78 (0%) 0/80 (0%) | |ADJUSTED (b) | 2.3% 0.0% 6.5% 4.8% | 2.4% 0.0% 0.0% 0.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 1/43 (2%) 0/43 (0%) 2/44 (5%) 2/42 (5%) | 1/41 (2%) 0/38 (0%) 0/42 (0%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | 736 (T) --- 583 736 (T) | 736 (T) --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.231 P=0.500N P=0.315 P=0.492 | P=0.296N P=0.515N P=0.495N P=0.481N | |INCIDENTAL TUMOR | P=0.172 P=0.500N P=0.236 P=0.492 | P=0.296N P=0.515N P=0.495N P=0.481N | |LOGISTIC REGRESSION | P=0.238 P=0.500N P=0.312 P=0.492 | P=0.296N P=0.515N P=0.495N P=0.481N | |COCHRAN-ARMITAGE | P=0.240 | P=0.310N | |FISHER EXACT | P=0.503N P=0.305 P=0.500 | P=0.500N P=0.506N P=0.500N | |=================================================================================================================================| | | |Liver | | Hemangiosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/80 (0%) 0/79 (0%) 3/79 (4%) 0/80 (0%) | 0/80 (0%) 0/80 (0%) 0/78 (0%) 0/80 (0%) | |ADJUSTED (b) | 0.0% 0.0% 6.2% 0.0% | 0.0% 0.0% 0.0% 0.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 0/43 (0%) 0/43 (0%) 2/44 (5%) 0/42 (0%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | --- --- 460 (I) --- | --- --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.531 (e) P=0.126 (e) | (e) (e) (e) (e) | |INCIDENTAL TUMOR | P=0.531 (e) P=0.126 (e) | (e) (e) (e) (e) | |LOGISTIC REGRESSION | P=0.535 (e) P=0.122 (e) | (e) (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.535 | (e) | |FISHER EXACT | (e) P=0.120 (e) | (e) (e) (e) | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 6 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |Liver | | Hepatocellular Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 23/80 (29%) 19/79 (24%) 19/79 (24%) 20/80 (25%) | 13/80 (16%) 13/80 (16%) 13/78 (17%) 16/80 (20%) | |ADJUSTED (b) | 44.6% 42.7% 40.7% 42.7% | 29.6% 30.5% 31.0% 33.8% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 3/10 (30%) 0/10 (0%) 2/10 (20%) 2/10 (20%) | 1/10 (10%) 2/10 (20%) 0/10 (0%) 1/9 (11%) | |TERMINAL (d) | 16/43 (37%) 18/43 (42%) 17/44 (39%) 16/42 (38%) | 11/41 (27%) 10/38 (26%) 13/42 (31%) 14/45 (31%) | |FIRST INCIDENCE (DAYS) | 281 (I) 281 (I) 460 (I) 460 (I) | 461 (I) 461 (I) 736 (T) 461 (I) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.393N P=0.286N P=0.262N P=0.383N | P=0.395 P=0.517 P=0.564N P=0.424 | |INCIDENTAL TUMOR | P=0.405N P=0.423N P=0.317N P=0.359N | P=0.349 P=0.577 P=0.534N P=0.405 | |LOGISTIC REGRESSION | P=0.363N P=0.282N P=0.271N P=0.352N | P=0.306 P=0.563 P=0.587 P=0.356 | |COCHRAN-ARMITAGE | P=0.370N | P=0.279 | |FISHER EXACT | P=0.312N P=0.312N P=0.361N | P=0.585N P=0.557 P=0.341 | |=================================================================================================================================| | | |Liver | | Hepatocellular Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 15/80 (19%) 13/79 (16%) 10/79 (13%) 15/80 (19%) | 10/80 (13%) 3/80 (4%) 1/78 (1%) 6/80 (8%) | |ADJUSTED (b) | 32.5% 27.2% 21.3% 34.0% | 22.9% 7.2% 2.2% 12.7% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 12/43 (28%) 9/43 (21%) 7/44 (16%) 13/42 (31%) | 8/41 (20%) 2/38 (5%) 0/42 (0%) 4/45 (9%) | |FIRST INCIDENCE (DAYS) | 553 460 (I) 667 676 | 538 561 621 555 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.511 P=0.413N P=0.174N P=0.559 | P=0.179N P=0.051N P=0.006N** P=0.170N | |INCIDENTAL TUMOR | P=0.463N P=0.336N P=0.093N P=0.574N | P=0.217N P=0.036N* P=0.009N** P=0.267N | |LOGISTIC REGRESSION | P=0.508 P=0.535N P=0.162N P=0.579N | P=0.293N P=0.042N* P=0.006N** P=0.260N | |COCHRAN-ARMITAGE | P=0.533 | P=0.224N | |FISHER EXACT | P=0.432N P=0.201N P=0.580N | P=0.040N* P=0.005N** P=0.215N | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 7 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |Liver | | Hepatocellular Carcinoma or Hepatocellular Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 33/80 (41%) 28/79 (35%) 26/79 (33%) 30/80 (38%) | 22/80 (28%) 16/80 (20%) 14/78 (18%) 19/80 (24%) | |ADJUSTED (b) | 62.7% 57.8% 52.7% 63.4% | 48.3% 36.8% 32.5% 39.3% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 3/10 (30%) 1/10 (10%) 2/10 (20%) 2/10 (20%) | 1/10 (10%) 2/10 (20%) 0/10 (0%) 1/9 (11%) | |TERMINAL (d) | 24/43 (56%) 23/43 (53%) 21/44 (48%) 25/42 (60%) | 18/41 (44%) 12/38 (32%) 13/42 (31%) 16/45 (36%) | |FIRST INCIDENCE (DAYS) | 281 (I) 281 (I) 460 (I) 460 (I) | 461 (I) 461 (I) 621 461 (I) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.413N P=0.244N P=0.131N P=0.402N | P=0.249N P=0.227N P=0.069N P=0.250N | |INCIDENTAL TUMOR | P=0.323N P=0.239N P=0.091N P=0.339N | P=0.290N P=0.160N P=0.076N P=0.300N | |LOGISTIC REGRESSION | P=0.367N P=0.232N P=0.122N P=0.354N | P=0.341N P=0.179N P=0.078N P=0.320N | |COCHRAN-ARMITAGE | P=0.381N | P=0.391N | |FISHER EXACT | P=0.278N P=0.178N P=0.373N | P=0.177N P=0.107N P=0.359N | |=================================================================================================================================| | | |Liver | | Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 33/80 (41%) 28/79 (35%) 26/79 (33%) 30/80 (38%) | 22/80 (28%) 16/80 (20%) 14/78 (18%) 19/80 (24%) | |ADJUSTED (b) | 62.7% 57.8% 52.7% 63.4% | 48.3% 36.8% 32.5% 39.3% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 3/10 (30%) 1/10 (10%) 2/10 (20%) 2/10 (20%) | 1/10 (10%) 2/10 (20%) 0/10 (0%) 1/9 (11%) | |TERMINAL (d) | 24/43 (56%) 23/43 (53%) 21/44 (48%) 25/42 (60%) | 18/41 (44%) 12/38 (32%) 13/42 (31%) 16/45 (36%) | |FIRST INCIDENCE (DAYS) | 281 (I) 281 (I) 460 (I) 460 (I) | 461 (I) 461 (I) 621 461 (I) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.413N P=0.244N P=0.131N P=0.402N | P=0.249N P=0.227N P=0.069N P=0.250N | |INCIDENTAL TUMOR | P=0.323N P=0.239N P=0.091N P=0.339N | P=0.290N P=0.160N P=0.076N P=0.300N | |LOGISTIC REGRESSION | P=0.367N P=0.232N P=0.122N P=0.354N | P=0.341N P=0.179N P=0.078N P=0.320N | |COCHRAN-ARMITAGE | P=0.381N | P=0.391N | |FISHER EXACT | P=0.278N P=0.178N P=0.373N | P=0.177N P=0.107N P=0.359N | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 8 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 8/80 (10%) 7/79 (9%) 12/79 (15%) 12/80 (15%) | 2/80 (3%) 4/80 (5%) 4/78 (5%) 5/80 (6%) | |ADJUSTED (b) | 16.7% 16.3% 25.7% 27.4% | 4.9% 10.5% 8.8% 11.1% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 1/10 (10%) 0/10 (0%) 1/10 (10%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/9 (0%) | |TERMINAL (d) | 5/43 (12%) 7/43 (16%) 10/44 (23%) 11/42 (26%) | 2/41 (5%) 4/38 (11%) 3/42 (7%) 5/45 (11%) | |FIRST INCIDENCE (DAYS) | 460 (I) 736 (T) 460 (I) 460 (I) | 736 (T) 736 (T) 461 (I) 736 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.112 P=0.501N P=0.252 P=0.218 | P=0.249 P=0.302 P=0.348 P=0.256 | |INCIDENTAL TUMOR | P=0.088 P=0.500 P=0.217 P=0.129 | P=0.249 P=0.302 P=0.348 P=0.256 | |LOGISTIC REGRESSION | P=0.121 P=0.494N P=0.242 P=0.232 | P=0.215 P=0.302 P=0.331 P=0.256 | |COCHRAN-ARMITAGE | P=0.130 | P=0.199 | |FISHER EXACT | P=0.510N P=0.228 P=0.237 | P=0.341 P=0.329 P=0.221 | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/80 (1%) 4/79 (5%) 2/79 (3%) 2/80 (3%) | 4/80 (5%) 1/80 (1%) 2/78 (3%) 1/80 (1%) | |ADJUSTED (b) | 2.3% 9.3% 4.4% 4.8% | 9.2% 2.6% 4.6% 2.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 1/43 (2%) 4/43 (9%) 1/44 (2%) 2/42 (5%) | 3/41 (7%) 1/38 (3%) 1/42 (2%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 718 736 (T) | 538 736 (T) 723 551 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.567 P=0.180 P=0.511 P=0.492 | P=0.148N P=0.200N P=0.329N P=0.164N | |INCIDENTAL TUMOR | P=0.579N P=0.180 P=0.624 P=0.492 | P=0.213N P=0.226N P=0.537N P=0.155N | |LOGISTIC REGRESSION | P=0.578 P=0.178 P=0.512 P=0.492 | P=0.165N P=0.187N P=0.342N P=0.211N | |COCHRAN-ARMITAGE | P=0.575 | P=0.171N | |FISHER EXACT | P=0.180 P=0.495 P=0.500 | P=0.184N P=0.353N P=0.184N | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 9 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 9/80 (11%) 11/79 (14%) 14/79 (18%) 13/80 (16%) | 5/80 (6%) 5/80 (6%) 6/78 (8%) 6/80 (8%) | |ADJUSTED (b) | 18.9% 25.6% 29.5% 29.8% | 11.6% 13.2% 13.1% 12.9% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 1/10 (10%) 0/10 (0%) 1/10 (10%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/9 (0%) | |TERMINAL (d) | 6/43 (14%) 11/43 (26%) 11/44 (25%) 12/42 (29%) | 4/41 (10%) 5/38 (13%) 4/42 (10%) 5/45 (11%) | |FIRST INCIDENCE (DAYS) | 460 (I) 736 (T) 460 (I) 460 (I) | 538 736 (T) 461 (I) 551 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.181 P=0.403 P=0.199 P=0.225 | P=0.487 P=0.587 P=0.515 P=0.556 | |INCIDENTAL TUMOR | P=0.161 P=0.218 P=0.195 P=0.136 | P=0.416 P=0.561 P=0.352 P=0.554 | |LOGISTIC REGRESSION | P=0.195 P=0.411 P=0.187 P=0.240 | P=0.431 P=0.609 P=0.491 P=0.513 | |COCHRAN-ARMITAGE | P=0.207 | P=0.409 | |FISHER EXACT | P=0.394 P=0.175 P=0.246 | P=0.627N P=0.482 P=0.500 | |=================================================================================================================================| | | |Ovary | | Cystadenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 0/78 (0%) 0/80 (0%) 1/77 (1%) 2/79 (3%) | |ADJUSTED (b) | | 0.0% 0.0% 2.4% 4.5% | |INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | | 0/40 (0%) 0/38 (0%) 1/41 (2%) 2/44 (5%) | |FIRST INCIDENCE (DAYS) | | --- --- 736 (T) 736 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | | P=0.084 (e) P=0.505 P=0.260 | |INCIDENTAL TUMOR | | P=0.084 (e) P=0.505 P=0.260 | |LOGISTIC REGRESSION | | P=0.084 (e) P=0.505 P=0.260 | |COCHRAN-ARMITAGE | | P=0.070 | |FISHER EXACT | | (e) P=0.497 P=0.252 | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 10 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis or Unspecified Site | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/78 (0%) 0/79 (0%) 0/74 (0%) 0/74 (0%) | 6/76 (8%) 8/76 (11%) 6/76 (8%) 9/79 (11%) | |ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 15.4% 21.2% 15.0% 20.5% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 0/41 (0%) 0/43 (0%) 0/41 (0%) 0/39 (0%) | 5/37 (14%) 6/34 (18%) 6/40 (15%) 9/44 (20%) | |FIRST INCIDENCE (DAYS) | --- --- --- --- | 677 561 736 (T) 736 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | (e) (e) (e) (e) | P=0.447 P=0.336 P=0.571N P=0.413 | |INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.389 P=0.427 P=0.600N P=0.338 | |LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.388 P=0.358 P=0.578N P=0.377 | |COCHRAN-ARMITAGE | (e) | P=0.320 | |FISHER EXACT | (e) (e) (e) | P=0.390 P=0.618N P=0.322 | |=================================================================================================================================| | | |Pituitary Gland: Pars Intermedia | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/78 (0%) 0/79 (0%) 0/74 (0%) 0/74 (0%) | 0/76 (0%) 1/76 (1%) 0/76 (0%) 2/79 (3%) | |ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 2.2% 0.0% 4.5% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 0/41 (0%) 0/43 (0%) 0/41 (0%) 0/39 (0%) | 0/37 (0%) 0/34 (0%) 0/40 (0%) 2/44 (5%) | |FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 645 --- 736 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | (e) (e) (e) (e) | P=0.170 P=0.496 (e) P=0.277 | |INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.090 P=0.567 (e) P=0.277 | |LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.160 P=0.497 (e) P=0.277 | |COCHRAN-ARMITAGE | (e) | P=0.149 | |FISHER EXACT | (e) (e) (e) | P=0.500 (e) P=0.258 | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 11 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |Skin | | Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 0/80 (0%) 1/79 (1%) 0/79 (0%) 0/80 (0%) | 2/80 (3%) 2/80 (3%) 1/78 (1%) 1/80 (1%) | |ADJUSTED (b) | 0.0% 2.3% 0.0% 0.0% | 4.6% 4.9% 2.4% 2.2% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 0/43 (0%) 1/43 (2%) 0/44 (0%) 0/42 (0%) | 1/41 (2%) 1/38 (3%) 1/42 (2%) 1/45 (2%) | |FIRST INCIDENCE (DAYS) | --- 736 (T) --- --- | 677 677 736 (T) 736 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.562N P=0.500 (e) (e) | P=0.307N P=0.667 P=0.497N P=0.476N | |INCIDENTAL TUMOR | P=0.562N P=0.500 (e) (e) | P=0.451N P=0.650N P=0.553N P=0.641N | |LOGISTIC REGRESSION | P=0.562N P=0.500 (e) (e) | P=0.323N P=0.685 P=0.501N P=0.491N | |COCHRAN-ARMITAGE | P=0.558N | P=0.338N | |FISHER EXACT | P=0.497 (e) (e) | P=0.690N P=0.510N P=0.500N | |=================================================================================================================================| | | |Skin | | Fibrosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 0/80 (0%) 1/79 (1%) 0/79 (0%) 0/80 (0%) | 2/80 (3%) 1/80 (1%) 1/78 (1%) 0/80 (0%) | |ADJUSTED (b) | 0.0% 2.3% 0.0% 0.0% | 4.6% 2.4% 2.4% 0.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 0/43 (0%) 1/43 (2%) 0/44 (0%) 0/42 (0%) | 1/41 (2%) 0/38 (0%) 1/42 (2%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | --- 736 (T) --- --- | 677 677 736 (T) --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.562N P=0.500 (e) (e) | P=0.144N P=0.525N P=0.497N P=0.227N | |INCIDENTAL TUMOR | P=0.562N P=0.500 (e) (e) | P=0.247N P=0.430N P=0.553N P=0.380N | |LOGISTIC REGRESSION | P=0.562N P=0.500 (e) (e) | P=0.150N P=0.509N P=0.501N P=0.233N | |COCHRAN-ARMITAGE | P=0.558N | P=0.156N | |FISHER EXACT | P=0.497 (e) (e) | P=0.500N P=0.510N P=0.248N | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 12 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |Skin | | Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 0/80 (0%) 1/79 (1%) 0/79 (0%) 0/80 (0%) | 2/80 (3%) 2/80 (3%) 1/78 (1%) 1/80 (1%) | |ADJUSTED (b) | 0.0% 2.3% 0.0% 0.0% | 4.6% 4.9% 2.4% 2.2% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 0/43 (0%) 1/43 (2%) 0/44 (0%) 0/42 (0%) | 1/41 (2%) 1/38 (3%) 1/42 (2%) 1/45 (2%) | |FIRST INCIDENCE (DAYS) | --- 736 (T) --- --- | 677 677 736 (T) 736 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.562N P=0.500 (e) (e) | P=0.307N P=0.667 P=0.497N P=0.476N | |INCIDENTAL TUMOR | P=0.562N P=0.500 (e) (e) | P=0.451N P=0.650N P=0.553N P=0.641N | |LOGISTIC REGRESSION | P=0.562N P=0.500 (e) (e) | P=0.323N P=0.685 P=0.501N P=0.491N | |COCHRAN-ARMITAGE | P=0.558N | P=0.338N | |FISHER EXACT | P=0.497 (e) (e) | P=0.690N P=0.510N P=0.500N | |=================================================================================================================================| | | |Spleen | | Hemangiosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/80 (5%) 1/79 (1%) 1/79 (1%) 1/79 (1%) | 3/80 (4%) 1/80 (1%) 1/78 (1%) 1/80 (1%) | |ADJUSTED (b) | 9.3% 2.3% 2.3% 2.4% | 7.3% 2.3% 2.4% 2.2% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 4/43 (9%) 1/43 (2%) 1/44 (2%) 1/42 (2%) | 3/41 (7%) 0/38 (0%) 1/42 (2%) 1/45 (2%) | |FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 736 (T) 736 (T) | 736 (T) 652 736 (T) 736 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.140N P=0.180N P=0.173N P=0.187N | P=0.218N P=0.329N P=0.297N P=0.273N | |INCIDENTAL TUMOR | P=0.140N P=0.180N P=0.173N P=0.187N | P=0.270N P=0.297N P=0.297N P=0.273N | |LOGISTIC REGRESSION | P=0.140N P=0.178N P=0.173N P=0.185N | P=0.232N P=0.317N P=0.297N P=0.273N | |COCHRAN-ARMITAGE | P=0.141N | P=0.247N | |FISHER EXACT | P=0.187N P=0.187N P=0.187N | P=0.310N P=0.320N P=0.310N | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 13 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |Stomach, Forestomach | | Squamous Cell Carcinoma or Papilloma Squamous | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 1/80 (1%) 0/79 (0%) 2/79 (3%) 0/80 (0%) | 0/80 (0%) 1/80 (1%) 0/78 (0%) 0/80 (0%) | |ADJUSTED (b) | 2.3% 0.0% 4.5% 0.0% | 0.0% 2.4% 0.0% 0.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 1/43 (2%) 0/43 (0%) 2/44 (5%) 0/42 (0%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | 736 (T) --- 736 (T) --- | --- 677 --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.471N P=0.500N P=0.508 P=0.505N | P=0.552N P=0.486 (e) (e) | |INCIDENTAL TUMOR | P=0.471N P=0.500N P=0.508 P=0.505N | P=0.813N P=0.567 (e) (e) | |LOGISTIC REGRESSION | P=0.471N P=0.500N P=0.508 P=0.505N | P=0.556N P=0.496 (e) (e) | |COCHRAN-ARMITAGE | P=0.465N | P=0.559N | |FISHER EXACT | P=0.503N P=0.495 P=0.500N | P=0.500 (e) (e) | |=================================================================================================================================| | | |Stomach, Forestomach | | Squamous Cell Papilloma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 0/80 (0%) 0/79 (0%) 2/79 (3%) 0/80 (0%) | 0/80 (0%) 1/80 (1%) 0/78 (0%) 0/80 (0%) | |ADJUSTED (b) | 0.0% 0.0% 4.5% 0.0% | 0.0% 2.4% 0.0% 0.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 0/43 (0%) 0/43 (0%) 2/44 (5%) 0/42 (0%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | --- --- 736 (T) --- | --- 677 --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.587 (e) P=0.244 (e) | P=0.552N P=0.486 (e) (e) | |INCIDENTAL TUMOR | P=0.587 (e) P=0.244 (e) | P=0.813N P=0.567 (e) (e) | |LOGISTIC REGRESSION | P=0.587 (e) P=0.244 (e) | P=0.556N P=0.496 (e) (e) | |COCHRAN-ARMITAGE | P=0.591 | P=0.559N | |FISHER EXACT | (e) P=0.245 (e) | P=0.500 (e) (e) | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 14 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |Thyroid Gland: Follicular Cell | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/80 (0%) 0/79 (0%) 2/79 (3%) 1/80 (1%) | 1/79 (1%) 0/80 (0%) 1/78 (1%) 0/80 (0%) | |ADJUSTED (b) | 0.0% 0.0% 4.5% 2.4% | 2.0% 0.0% 2.4% 0.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 0/43 (0%) 0/43 (0%) 2/44 (5%) 1/42 (2%) | 0/41 (0%) 0/38 (0%) 1/42 (2%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | --- --- 736 (T) 736 (T) | 523 --- 736 (T) --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.237 (e) P=0.244 P=0.495 | P=0.398N P=0.504N P=0.758 P=0.500N | |INCIDENTAL TUMOR | P=0.237 (e) P=0.244 P=0.495 | P=0.539N P=0.581N P=0.505 P=0.718N | |LOGISTIC REGRESSION | P=0.237 (e) P=0.244 P=0.495 | P=0.406N P=0.497N P=0.760 P=0.498N | |COCHRAN-ARMITAGE | P=0.244 | P=0.408N | |FISHER EXACT | (e) P=0.245 P=0.500 | P=0.497N P=0.748 P=0.497N | |=================================================================================================================================| | | |Tooth | | Odontoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 2/80 (3%) 2/79 (3%) 2/79 (3%) 1/80 (1%) | 0/80 (0%) 0/80 (0%) 0/78 (0%) 0/80 (0%) | |ADJUSTED (b) | 4.7% 4.7% 4.5% 2.4% | 0.0% 0.0% 0.0% 0.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 2/43 (5%) 2/43 (5%) 2/44 (5%) 1/42 (2%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 736 (T) 736 (T) | --- --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.379N P=0.695 P=0.686N P=0.508N | (e) (e) (e) (e) | |INCIDENTAL TUMOR | P=0.379N P=0.695 P=0.686N P=0.508N | (e) (e) (e) (e) | |LOGISTIC REGRESSION | P=0.379N P=0.695 P=0.686N P=0.508N | (e) (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.372N | (e) | |FISHER EXACT | P=0.685 P=0.685 P=0.500N | (e) (e) (e) | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 15 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |Uterus | | Polyp Stromal | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | # # # # | |----------- | | | |OVERALL (a) | | 2/80 (3%) 1/80 (1%) 3/78 (4%) 0/80 (0%) | |ADJUSTED (b) | | 4.9% 2.6% 7.1% 0.0% | |INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | | 2/41 (5%) 1/38 (3%) 3/42 (7%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | | 736 (T) 736 (T) 736 (T) --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | | P=0.213N P=0.527N P=0.511 P=0.218N | |INCIDENTAL TUMOR | | P=0.213N P=0.527N P=0.511 P=0.218N | |LOGISTIC REGRESSION | | P=0.213N P=0.527N P=0.511 P=0.218N | |COCHRAN-ARMITAGE | | P=0.247N | |FISHER EXACT | | P=0.500N P=0.488 P=0.248N | |=================================================================================================================================| | | |All Organs | | Hemangioma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 1/80 (1%) 0/79 (0%) 0/79 (0%) 0/80 (0%) | 0/80 (0%) 0/80 (0%) 4/78 (5%) 0/80 (0%) | |ADJUSTED (b) | 2.3% 0.0% 0.0% 0.0% | 0.0% 0.0% 9.5% 0.0% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 1/43 (2%) 0/43 (0%) 0/44 (0%) 0/42 (0%) | 0/41 (0%) 0/38 (0%) 4/42 (10%) 0/45 (0%) | |FIRST INCIDENCE (DAYS) | 736 (T) --- --- --- | --- --- 736 (T) --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.311N P=0.500N P=0.495N P=0.505N | P=0.532 (e) P=0.066 (e) | |INCIDENTAL TUMOR | P=0.311N P=0.500N P=0.495N P=0.505N | P=0.532 (e) P=0.066 (e) | |LOGISTIC REGRESSION | P=0.311N P=0.500N P=0.495N P=0.505N | P=0.532 (e) P=0.066 (e) | |COCHRAN-ARMITAGE | P=0.309N | P=0.494 | |FISHER EXACT | P=0.503N P=0.503N P=0.500N | (e) P=0.057 (e) | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 16 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |All Organs | | Hemangiosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 5/80 (6%) 2/79 (3%) 4/79 (5%) 2/80 (3%) | 4/80 (5%) 1/80 (1%) 1/78 (1%) 1/80 (1%) | |ADJUSTED (b) | 11.6% 4.7% 8.4% 4.7% | 9.8% 2.3% 2.4% 2.2% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 5/43 (12%) 2/43 (5%) 3/44 (7%) 1/42 (2%) | 4/41 (10%) 0/38 (0%) 1/42 (2%) 1/45 (2%) | |FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 460 (I) 731 | 736 (T) 652 736 (T) 736 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.245N P=0.216N P=0.487N P=0.227N | P=0.119N P=0.202N P=0.172N P=0.153N | |INCIDENTAL TUMOR | P=0.220N P=0.216N P=0.487N P=0.156N | P=0.149N P=0.179N P=0.172N P=0.153N | |LOGISTIC REGRESSION | P=0.236N P=0.216N P=0.488N P=0.212N | P=0.128N P=0.191N P=0.172N P=0.153N | |COCHRAN-ARMITAGE | P=0.239N | P=0.140N | |FISHER EXACT | P=0.226N P=0.508N P=0.221N | P=0.184N P=0.191N P=0.184N | |=================================================================================================================================| | | |All Organs | | Hemangiosarcoma or Hemangioma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 6/80 (8%) 2/79 (3%) 4/79 (5%) 2/80 (3%) | 4/80 (5%) 1/80 (1%) 5/78 (6%) 1/80 (1%) | |ADJUSTED (b) | 14.0% 4.7% 8.4% 4.7% | 9.8% 2.3% 11.9% 2.2% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 6/43 (14%) 2/43 (5%) 3/44 (7%) 1/42 (2%) | 4/41 (10%) 0/38 (0%) 5/42 (12%) 1/45 (2%) | |FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 460 (I) 731 | 736 (T) 652 736 (T) 736 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.162N P=0.134N P=0.358N P=0.143N | P=0.212N P=0.202N P=0.515 P=0.153N | |INCIDENTAL TUMOR | P=0.143N P=0.134N P=0.358N P=0.094N | P=0.252N P=0.179N P=0.515 P=0.153N | |LOGISTIC REGRESSION | P=0.153N P=0.134N P=0.357N P=0.130N | P=0.231N P=0.191N P=0.515 P=0.153N | |COCHRAN-ARMITAGE | P=0.158N | P=0.257N | |FISHER EXACT | P=0.142N P=0.381N P=0.138N | P=0.184N P=0.484 P=0.184N | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 17 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |All Organs | | Histiocytic Sarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 0/80 (0%) 2/79 (3%) 0/79 (0%) 2/80 (3%) | 1/80 (1%) 3/80 (4%) 2/78 (3%) 1/80 (1%) | |ADJUSTED (b) | 0.0% 3.9% 0.0% 4.4% | 2.4% 6.6% 4.6% 2.2% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 0/43 (0%) 0/43 (0%) 0/44 (0%) 0/42 (0%) | 1/41 (2%) 0/38 (0%) 1/42 (2%) 1/45 (2%) | |FIRST INCIDENCE (DAYS) | --- 397 --- 682 | 736 (T) 571 653 736 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.257 P=0.242 (e) P=0.245 | P=0.441N P=0.296 P=0.506 P=0.741N | |INCIDENTAL TUMOR | P=0.503 P=0.773 (e) P=0.581 | P=0.591 P=0.457 P=0.447 P=0.741N | |LOGISTIC REGRESSION | P=0.254 P=0.236 (e) P=0.239 | P=0.580 P=0.301 P=0.498 P=0.741N | |COCHRAN-ARMITAGE | P=0.254 | P=0.470N | |FISHER EXACT | P=0.245 (e) P=0.248 | P=0.310 P=0.490 P=0.752N | |=================================================================================================================================| | | |All Organs | | Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated | | Cell Type | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 3/80 (4%) 3/79 (4%) 2/79 (3%) 2/80 (3%) | 4/80 (5%) 6/80 (8%) 6/78 (8%) 6/80 (8%) | |ADJUSTED (b) | 6.7% 7.0% 4.5% 4.8% | 9.5% 15.4% 13.8% 13.3% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 2/43 (5%) 3/43 (7%) 2/44 (5%) 2/42 (5%) | 3/41 (7%) 5/38 (13%) 5/42 (12%) 6/45 (13%) | |FIRST INCIDENCE (DAYS) | 603 736 (T) 736 (T) 736 (T) | 698 700 607 736 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.379N P=0.661 P=0.492N P=0.510N | P=0.440 P=0.324 P=0.386 P=0.428 | |INCIDENTAL TUMOR | P=0.441N P=0.500 P=0.570N P=0.633N | P=0.369 P=0.373 P=0.393 P=0.336 | |LOGISTIC REGRESSION | P=0.368N P=0.657N P=0.490N P=0.498N | P=0.392 P=0.338 P=0.369 P=0.399 | |COCHRAN-ARMITAGE | P=0.370N | P=0.354 | |FISHER EXACT | P=0.653 P=0.506N P=0.500N | P=0.373 P=0.357 P=0.373 | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 18 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |All Organs | | Benign Tumors | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 33/80 (41%) 24/79 (30%) 35/79 (44%) 35/80 (44%) | 28/80 (35%) 31/80 (39%) 25/78 (32%) 32/80 (40%) | |ADJUSTED (b) | 61.3% 52.7% 71.1% 72.4% | 61.8% 68.2% 56.5% 66.5% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 5/10 (50%) 1/10 (10%) 3/10 (30%) 3/10 (30%) | 1/10 (10%) 2/10 (20%) 1/10 (10%) 1/9 (11%) | |TERMINAL (d) | 23/43 (53%) 22/43 (51%) 30/44 (68%) 29/42 (69%) | 24/41 (59%) 24/38 (63%) 23/42 (55%) 29/45 (64%) | |FIRST INCIDENCE (DAYS) | 281 (I) 281 (I) 460 (I) 460 (I) | 461 (I) 461 (I) 461 (I) 461 (I) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.143 P=0.078N P=0.477 P=0.390 | P=0.501N P=0.237 P=0.311N P=0.456 | |INCIDENTAL TUMOR | P=0.099 P=0.176N P=0.385 P=0.309 | P=0.476 P=0.359 P=0.344N P=0.384 | |LOGISTIC REGRESSION | P=0.167 P=0.074N P=0.453 P=0.429 | P=0.382 P=0.303 P=0.362N P=0.316 | |COCHRAN-ARMITAGE | P=0.202 | P=0.345 | |FISHER EXACT | P=0.103N P=0.410 P=0.437 | P=0.372 P=0.412N P=0.312 | |=================================================================================================================================| | | |All Organs | | Malignant Tumors | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 22/80 (28%) 23/79 (29%) 17/79 (22%) 21/80 (26%) | 22/80 (28%) 16/80 (20%) 15/78 (19%) 19/80 (24%) | |ADJUSTED (b) | 47.7% 46.5% 35.2% 45.7% | 47.7% 35.1% 32.5% 38.7% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 0/10 (0%) 1/10 (10%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |TERMINAL (d) | 19/43 (44%) 17/43 (40%) 13/44 (30%) 17/42 (40%) | 17/41 (41%) 9/38 (24%) 11/42 (26%) 15/45 (33%) | |FIRST INCIDENCE (DAYS) | 553 397 460 (I) 676 | 538 561 607 471 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.409N P=0.505 P=0.198N P=0.531N | P=0.264N P=0.244N P=0.114N P=0.250N | |INCIDENTAL TUMOR | P=0.240N P=0.467N P=0.124N P=0.395N | P=0.536 P=0.089N P=0.164N P=0.487N | |LOGISTIC REGRESSION | P=0.371N P=0.512 P=0.183N P=0.489N | P=0.533 P=0.072N P=0.145N P=0.412N | |COCHRAN-ARMITAGE | P=0.383N | P=0.400N | |FISHER EXACT | P=0.480 P=0.245N P=0.500N | P=0.177N P=0.149N P=0.359N | |=================================================================================================================================| DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 19 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM | | | | | |=================================================================================================================================| | | |All Organs | | Malignant and Benign Tumors | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # | # # # # | |----------- | | | |OVERALL (a) | 44/80 (55%) 38/79 (48%) 42/79 (53%) 42/80 (53%) | 41/80 (51%) 41/80 (51%) 33/78 (42%) 42/80 (53%) | |ADJUSTED (b) | 79.6% 74.1% 82.2% 82.2% | 81.8% 83.5% 70.0% 83.9% | |INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 2 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |INTERIM SACRIFICE 3 (c)| 5/10 (50%) 2/10 (20%) 3/10 (30%) 3/10 (30%) | 1/10 (10%) 2/10 (20%) 1/10 (10%) 1/9 (11%) | |TERMINAL (d) | 32/43 (74%) 30/43 (70%) 35/44 (80%) 33/42 (79%) | 32/41 (78%) 30/38 (79%) 28/42 (67%) 37/45 (82%) | |FIRST INCIDENCE (DAYS) | 281 (I) 281 (I) 460 (I) 460 (I) | 425 461 (I) 461 (I) 461 (I) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.495 P=0.194N P=0.367N P=0.483N | P=0.245N P=0.389 P=0.082N P=0.405N | |INCIDENTAL TUMOR | P=0.493N P=0.143N P=0.370N P=0.425N | P=0.511 P=0.526N P=0.174N P=0.430 | |LOGISTIC REGRESSION | P=0.520N P=0.170N P=0.384N P=0.420N | P=0.490 P=0.589 P=0.132N P=0.542 | |COCHRAN-ARMITAGE | P=0.511N | P=0.517 | |FISHER EXACT | P=0.238N P=0.471N P=0.437N | P=0.563N P=0.167N P=0.500 | |=================================================================================================================================| (a) Number of tumor-bearing animals / number of animals examined at site. (b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for intercurrent mortality. (c) Observed incidence at interim kill. Male interim sacrifices(days): 90 281 460 Female interim sacrifices(days): 90 282 461 (d) Observed incidence at terminal kill. (f) Beneath the control incidence are the P-values associated with the trend test. Beneath the dosed group incidence are the P-values corresponding to pairwise comparisons between the controls and that dosed group. The life table analysis regards tumors in animals dying prior to terminal kill as being (directly or indirectly) the cause of death. The incidental tumor test regards these lesions as non-fatal. Logistic regression is an alternative method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage and Fisher's exact tests compare directly the overall incidence rates. For all tests, a negative trend is indicated by "N". (e) Value of Statistic cannot be computed. (I) Interim sacrifice (T) Terminal sacrifice # Tumor rates based on number of animals necropsied. * To the right of any statistical result, indicates significance at (P<=0.05). ** To the right of any statistical result, indicates significance at (P<=0.01).