TDMS Study 05100-04 Pathology Tables
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1330-78-5
Lock Date: 12/13/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 2| 2| 2| 2| 2| 2| 2| 4| 2| 4| 4| 0| 4| 4| 0| 0| 2| 2| 4| 4| 0| 0| 2| 4|
DAY ON TEST | 9| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 6| 9| 6| 6| 9| 9| 8| 8| 6| 6| 9| 9| 8| 6|
| 0| 2| 6| 2| 2| 2| 2| 6| 2| 6| 1| 2| 0| 1| 1| 7| 7| 2| 6| 1| 1| 1| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic Active | 1|
Mixed Cell Focus | |
Necrosis | |
Bile Duct, Cyst | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + +|
Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Infarct | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 1 1 1 1|
Subcapsular, Hyperplasia | 1 1 1 2 1 1 2 1 2 2 1 2 2 1 1 1 2|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 2| 2| 2| 2| 2| 2| 2| 4| 2| 4| 4| 0| 4| 4| 0| 0| 2| 2| 4| 4| 0| 0| 2| 4|
DAY ON TEST | 9| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 6| 9| 6| 6| 9| 9| 8| 8| 6| 6| 9| 9| 8| 6|
| 0| 2| 6| 2| 2| 2| 2| 6| 2| 6| 1| 2| 0| 1| 1| 7| 7| 2| 6| 1| 1| 1| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + M + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
Inflammation | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Cyst | X X X X |
Corpus Luteum, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Cystic | 1 1 2 1 1 3 2 3 2 3 2 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Infarct | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 2| 2| 2| 2| 2| 2| 2| 4| 2| 4| 4| 0| 4| 4| 0| 0| 2| 2| 4| 4| 0| 0| 2| 4|
DAY ON TEST | 9| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 6| 9| 6| 6| 9| 9| 8| 8| 6| 6| 9| 9| 8| 6|
| 0| 2| 6| 2| 2| 2| 2| 6| 2| 6| 1| 2| 0| 1| 1| 7| 7| 2| 6| 1| 1| 1| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
Joint, Inflammation, Chronic Active | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | |
Respiratory Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation | |
__________________________________________________________________________|
Harderian Gland | + M + + + + + + M + M + + M + + +|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 2| 2| 2| 2| 2| 2| 2| 4| 2| 4| 4| 0| 4| 4| 0| 0| 2| 2| 4| 4| 0| 0| 2| 4|
DAY ON TEST | 9| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 6| 9| 6| 6| 9| 9| 8| 8| 6| 6| 9| 9| 8| 6|
| 0| 2| 6| 2| 2| 2| 2| 6| 2| 6| 1| 2| 0| 1| 1| 7| 7| 2| 6| 1| 1| 1| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infarct | |
Nephropathy | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 4| 4| 2| 0| 2| 0| 0| 0| 0| 2| 0| 2| 4| 4| 0| 4| 4| 4| 0| 7| 7| 7| 6| 7|
DAY ON TEST | 9| 6| 6| 8| 9| 8| 9| 9| 9| 9| 8| 9| 8| 6| 6| 9| 6| 6| 6| 9| 3| 3| 1| 9| 3|
| 7| 1| 2| 2| 0| 6| 1| 1| 7| 7| 2| 1| 2| 1| 2| 1| 1| 2| 1| 0| 9| 9| 2| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5|
0 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 9| 9| 9| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + +|
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Chronic Active | |
Mixed Cell Focus | |
Necrosis | 1 1 |
Bile Duct, Cyst | X |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Infarct | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | |
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 1 1 1|
Subcapsular, Hyperplasia | 2 1 1 1 1 2 1 1 2 1 1 2 1 1 2 1 2 2|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 4| 4| 2| 0| 2| 0| 0| 0| 0| 2| 0| 2| 4| 4| 0| 4| 4| 4| 0| 7| 7| 7| 6| 7|
DAY ON TEST | 9| 6| 6| 8| 9| 8| 9| 9| 9| 9| 8| 9| 8| 6| 6| 9| 6| 6| 6| 9| 3| 3| 1| 9| 3|
| 7| 1| 2| 2| 0| 6| 1| 1| 7| 7| 2| 1| 2| 1| 2| 1| 1| 2| 1| 0| 9| 9| 2| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5|
0 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 9| 9| 9| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M M + + + + + + M + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M|
Cyst | |
Pars Distalis, Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
Inflammation | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 4 4 |
Cyst | X X X|
Corpus Luteum, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Cystic | 3 2 1 2 3 3 3 2 4 1 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Infarct | |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + M + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + M + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 4| 4| 2| 0| 2| 0| 0| 0| 0| 2| 0| 2| 4| 4| 0| 4| 4| 4| 0| 7| 7| 7| 6| 7|
DAY ON TEST | 9| 6| 6| 8| 9| 8| 9| 9| 9| 9| 8| 9| 8| 6| 6| 9| 6| 6| 6| 9| 3| 3| 1| 9| 3|
| 7| 1| 2| 2| 0| 6| 1| 1| 7| 7| 2| 1| 2| 1| 2| 1| 1| 2| 1| 0| 9| 9| 2| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5|
0 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 9| 9| 9| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 4 4 1|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + M|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Joint, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | |
Respiratory Epithelium, Inflammation | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation | 3 |
__________________________________________________________________________|
Harderian Gland | + + M + + + + + + + M M + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 4| 4| 2| 0| 2| 0| 0| 0| 0| 2| 0| 2| 4| 4| 0| 4| 4| 4| 0| 7| 7| 7| 6| 7|
DAY ON TEST | 9| 6| 6| 8| 9| 8| 9| 9| 9| 9| 8| 9| 8| 6| 6| 9| 6| 6| 6| 9| 3| 3| 1| 9| 3|
| 7| 1| 2| 2| 0| 6| 1| 1| 7| 7| 2| 1| 2| 1| 2| 1| 1| 2| 1| 0| 9| 9| 2| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5|
0 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 9| 9| 9| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infarct | 1 |
Nephropathy | 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4|
| 9| 9| 9| 9| 9| 7| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Eosinophilic Focus | X X X X|
Hematopoietic Cell Proliferation | |
Inflammation, Chronic Active | |
Mixed Cell Focus | |
Necrosis | 1 |
Bile Duct, Cyst | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 2 3|
Duct, Cyst | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
Pigmentation, Ceroid | 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 2 1 1 1 2 1 2 2 2|
Subcapsular, Hyperplasia | 2 2 1 2 4 2 2 2 2 2 2 2 2 2 3 2 2 2 2 1 1 1 2 2 2|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4|
| 9| 9| 9| 9| 9| 7| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M + + M + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + M + M + + + + + + +|
Cyst | X X |
Pars Distalis, Hyperplasia | 1 3 1 1 1 1 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 4 |
Cyst | X X X |
Corpus Luteum, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Cystic | 1 1 2 1 2 2 1 1 3 2 2 2 3 2 2 2 2 2 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 2 |
Infarct | 4 |
Myelofibrosis | 2 1 2 1 2 2 1 1 2 1 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 3|
Fibrosis | 3|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4|
| 9| 9| 9| 9| 9| 7| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 1 2 1 3 4 2 1 3 1 1 3 |
Hyperplasia, Lymphoid | 2 2 1 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + M + + +|
Depletion Lymphoid | 4 3 |
Hyperplasia, Lymphoid | 2 |
Artery, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Inflammation, Chronic Active | |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | 2 |
Respiratory Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4|
| 9| 9| 9| 9| 9| 7| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infarct | 2 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| | |
DAY ON TEST | 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 2| 4| 4| 4| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 8| 3| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 79 |
Lymphoid Tissue, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 80 |
Basophilic Focus | X X X | 4 |
Eosinophilic Focus | X X X | 8 |
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
Mixed Cell Focus | X | 1 |
Necrosis | | 3 1.0|
Bile Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Fat, Necrosis | 4 4 | 4 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 80 |
Atrophy | | 4 2.3|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 79 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 |
Erosion | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 80 |
Infarct | | 1 3.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| | |
DAY ON TEST | 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 2| 4| 4| 4| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 8| 3| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Accessory Adrenal Cortical Nodule | X | 5 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 2 1 1 1 | 4 1.3|
Pigmentation, Ceroid | 1 2 1 1 1 1 1 1 1 2 2 2 1 1 1 1 1 1 1 1 | 68 1.2|
Subcapsular, Hyperplasia | 2 2 1 2 1 1 2 2 2 2 1 1 2 1 2 1 1 1 2 2 | 80 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + | 71 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 76 |
Cyst | | 2 |
Pars Distalis, Hyperplasia | 2 2 1 1 1 2 1 1 1 | 21 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 79 |
Inflammation | 1 | 1 1.0|
Follicle, Cyst | X | 3 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 | 7 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 2 |
Duct, Dilatation | | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + M + + + + + + + | 78 |
Angiectasis | 3 | 1 3.0|
Atrophy | 4 4 | 5 4.0|
Cyst | X X X X X X | 16 |
Corpus Luteum, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 80 |
Angiectasis | 4 | 1 4.0|
Hyperplasia, Cystic | 3 2 2 4 1 3 3 2 1 1 1 3 1 1 2 4 4 | 61 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 2 2 2 2 4 | 10 2.7|
Infarct | | 1 4.0|
Myelofibrosis | 1 1 1 1 1 2 2 | 18 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| | |
DAY ON TEST | 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 2| 4| 4| 4| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 8| 3| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + | 75 |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 78 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 80 |
Depletion Lymphoid | | 2 2.5|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 3 3 2 4 2 4 2 | 23 2.4|
Hyperplasia, Lymphoid | 2 1 | 5 1.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + + + + + + + | 75 |
Depletion Lymphoid | 4 | 3 3.7|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 79 |
Hyperplasia, Cystic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic Active | | 1 1.0|
Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 80 |
Joint, Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 95 |
Axon, Degeneration | 2 2 1 | 5 1.4|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 95 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia, Lymphoid | | 1 2.0|
Thrombosis | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| | |
DAY ON TEST | 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 2| 4| 4| 4| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 8| 3| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 80 |
Nasolacrimal Duct, Inflammation | | 1 2.0|
Respiratory Epithelium, Inflammation | 1 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 79 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + M + M + + + | 70 |
Hyperplasia | 3 | 3 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 80 |
Hydronephrosis | | 1 2.0|
Infarct | | 2 1.5|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 | 31 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + | 79 |
Artery, Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 0| 0| 4| 0| 2| 4| 0| 4| 0| 2| 0| 2| 4| 0|
DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 9| 9| 6| 9| 8| 6| 9| 6| 9| 8| 9| 8| 6| 9|
| 2| 2| 6| 2| 1| 2| 1| 6| 2| 1| 7| 1| 0| 2| 1| 6| 2| 7| 1| 7| 6| 1| 2| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
60 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Eosinophilic Focus | |
Fatty Change | |
Hematopoietic Cell Proliferation | |
Infarct | |
Inflammation, Chronic Active | |
Necrosis | |
Centrilobular, Degeneration | |
Serosa, Inflammation | |
__________________________________________________________________________|
Mesentery | |
Hemorrhage | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
Duct, Hyperplasia | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Degeneration | |
Inflammation, Chronic Active | |
Atrium, Thrombosis | |
Pericardium, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 0| 0| 4| 0| 2| 4| 0| 4| 0| 2| 0| 2| 4| 0|
DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 9| 9| 6| 9| 8| 6| 9| 6| 9| 8| 9| 8| 6| 9|
| 2| 2| 6| 2| 1| 2| 1| 6| 2| 1| 7| 1| 0| 2| 1| 6| 2| 7| 1| 7| 6| 1| 2| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
60 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Accessory Adrenal Cortical Nodule | |
Hyperplasia | |
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 |
Subcapsular, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 2 1 1 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
Inflammation, Suppurative | |
Thrombosis | |
Corpus Luteum, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Cystic | 1 1 2 1 2 2 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 0| 0| 4| 0| 2| 4| 0| 4| 0| 2| 0| 2| 4| 0|
DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 9| 9| 6| 9| 8| 6| 9| 6| 9| 8| 9| 8| 6| 9|
| 2| 2| 6| 2| 1| 2| 1| 6| 2| 1| 7| 1| 0| 2| 1| 6| 2| 7| 1| 7| 6| 1| 2| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
60 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
Capsule, Inflammation, Chronic | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | |
Pleura, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + M + + + + M + + + + + + M +|
Hemorrhage | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infarct | |
Nephropathy | 1 |
Renal Tubule, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 0| 0| 4| 4| 4| 0| 4| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 2| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 9| 6| 6| 6| 9| 6| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 8| 5| 3| 3| 3| 3|
| 2| 7| 0| 1| 1| 2| 7| 1| 1| 1| 2| 0| 1| 0| 1| 6| 2| 2| 2| 2| 4| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 6|
60 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Eosinophilic Focus | |
Fatty Change | |
Hematopoietic Cell Proliferation | |
Infarct | |
Inflammation, Chronic Active | |
Necrosis | 1 |
Centrilobular, Degeneration | |
Serosa, Inflammation | |
__________________________________________________________________________|
Mesentery | |
Hemorrhage | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Inflammation, Chronic Active | |
Atrium, Thrombosis | |
Pericardium, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 0| 0| 4| 4| 4| 0| 4| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 2| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 9| 6| 6| 6| 9| 6| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 8| 5| 3| 3| 3| 3|
| 2| 7| 0| 1| 1| 2| 7| 1| 1| 1| 2| 0| 1| 0| 1| 6| 2| 2| 2| 2| 4| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 6|
60 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Accessory Adrenal Cortical Nodule | X X |
Hyperplasia | |
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1|
Subcapsular, Hyperplasia | 1 1 2 2 2 1 1 2 1 2 1 1 1 1 1 1 1 2 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + + + M M + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X X |
Inflammation, Suppurative | |
Thrombosis | |
Corpus Luteum, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Cystic | 2 3 2 4 3 2 1 2 3 1 1 3 4 1 2 1|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 0| 0| 4| 4| 4| 0| 4| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 2| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 9| 6| 6| 6| 9| 6| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 8| 5| 3| 3| 3| 3|
| 2| 7| 0| 1| 1| 2| 7| 1| 1| 1| 2| 0| 1| 0| 1| 6| 2| 2| 2| 2| 4| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 6|
60 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
Capsule, Inflammation, Chronic | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | 1 2 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | |
Pleura, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + M M + M M + + M + + + + + + M + + +|
Hemorrhage | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infarct | |
Nephropathy | 1 1 1 1|
Renal Tubule, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|
| 8| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | |
Eosinophilic Focus | X X |
Fatty Change | 1 1 1 |
Hematopoietic Cell Proliferation | |
Infarct | 2 |
Inflammation, Chronic Active | 1 |
Necrosis | |
Centrilobular, Degeneration | |
Serosa, Inflammation | |
__________________________________________________________________________|
Mesentery | + + + |
Hemorrhage | 2 |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Hyperplasia | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Inflammation, Chronic Active | 1 |
Atrium, Thrombosis | |
Pericardium, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|
| 8| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Accessory Adrenal Cortical Nodule | X X |
Hyperplasia | 2 |
Pigmentation, Ceroid | 1 1 1 1 1 2 2 2 2 1 2 1 2 2 2 2 2 2 2 1 2 2 2 1 2|
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 4 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + M M + M M + M + + + + + + M M +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 1 1 3 2 1 1 2 1 4 1 2 2 1 1 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 3 4 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | X X X X X |
Inflammation, Suppurative | |
Thrombosis | |
Corpus Luteum, Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Cystic | 2 1 4 4 4 1 1 2 1 2 2 2 3 4 1 2 2 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 |
Myelofibrosis | 2 1 2 1 1 2 1 1 2 1 1 1 1|
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 2 2 1 1 1 1 1 1 2 2 1 4 |
Hyperplasia, Lymphoid | 2 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|
| 8| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + M + + + + + M + + + + M M + + + + + + + + + + +|
Depletion Lymphoid | 3 2 4 |
Hyperplasia, Lymphoid | 4 |
Capsule, Inflammation, Chronic | |
Epithelial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | 2 1 2 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 3 |
Pleura, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + M M + + M M + M M + + M + + + + + + + +|
Hemorrhage | |
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infarct | 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Dilatation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 6| | |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 9| 5| 3| 4| 3| 3| 3| 0| | |
| 0| 9| 9| 9| 9| 9| 9| 9| 3| 9| 1| 9| 6| 2| 9| 5| 9| 9| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + + + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + | 78 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 80 |
Angiectasis | | 1 1.0|
Basophilic Focus | X | 3 |
Eosinophilic Focus | X X | 4 |
Fatty Change | | 3 1.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Infarct | | 1 2.0|
Inflammation, Chronic Active | | 1 1.0|
Necrosis | 4 | 2 2.5|
Centrilobular, Degeneration | 3 | 1 3.0|
Serosa, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 80 |
Atrophy | 3 3 1 1 4 | 6 2.2|
Duct, Cyst | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 80 |
Duct, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 |
Erosion | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 80 |
Degeneration | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 1.0|
Atrium, Thrombosis | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 6| | |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 9| 5| 3| 4| 3| 3| 3| 0| | |
| 0| 9| 9| 9| 9| 9| 9| 9| 3| 9| 1| 9| 6| 2| 9| 5| 9| 9| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Pericardium, Inflammation, Chronic | | |
Active | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + M + + + + + + | 79 |
Accessory Adrenal Cortical Nodule | X X | 6 |
Hyperplasia | | 1 2.0|
Pigmentation, Ceroid | 1 2 2 1 1 1 2 1 1 2 2 1 1 2 2 1 2 2 2 | 69 1.4|
Subcapsular, Hyperplasia | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 | 79 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + M + + + + + + | 79 |
Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 2 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 67 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M M M + + + + + + + M + + + + + | 76 |
Cyst | X | 1 |
Pars Distalis, Hyperplasia | 1 1 2 1 2 2 | 23 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
Follicular Cell, Hyperplasia | 1 | 9 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 80 |
Atrophy | | 1 4.0|
Cyst | X X X X X X | 13 |
Inflammation, Suppurative | 4 | 1 4.0|
Thrombosis | X | 1 |
Corpus Luteum, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 80 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Cystic | 3 2 1 2 1 2 4 1 2 2 4 1 1 2 | 53 2.1|
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 6| | |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 9| 5| 3| 4| 3| 3| 3| 0| | |
| 0| 9| 9| 9| 9| 9| 9| 9| 3| 9| 1| 9| 6| 2| 9| 5| 9| 9| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 2 4 | 6 2.2|
Myelofibrosis | 2 1 1 1 1 1 1 1 1 1 | 23 1.2|
__________________________________________________________________________|____________|
Lymph Node | + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 77 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + M + + + + + + + + + + + + | 75 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 80 |
Depletion Lymphoid | | 1 2.0|
Hematopoietic Cell Proliferation | 4 2 1 3 4 3 4 | 20 2.1|
Hyperplasia, Lymphoid | 1 2 | 7 2.0|
__________________________________________________________________________|____________|
Thymus | M + + M + + + + + + + + + + + + + + + + | 74 |
Depletion Lymphoid | 1 3 3 2 3 4 | 9 2.8|
Hyperplasia, Lymphoid | 2 | 2 3.0|
Capsule, Inflammation, Chronic | 4 | 1 4.0|
Epithelial Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 80 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 80 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 80 |
Necrosis | 3 2 | 3 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 95 |
Axon, Degeneration | 2 | 6 1.7|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 95 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic Active | 2 3 | 3 2.0|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
Pleura, Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 79 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 6| | |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 9| 5| 3| 4| 3| 3| 3| 0| | |
| 0| 9| 9| 9| 9| 9| 9| 9| 3| 9| 1| 9| 6| 2| 9| 5| 9| 9| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + M + + + + M + M M + + + | 60 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 80 |
Hydronephrosis | 1 | 1 1.0|
Infarct | | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 31 1.0|
Renal Tubule, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 80 |
Serosa, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 0| 0| 4| 0| 2| 4| 0| 4| 0| 2| 0| 2| 4| 0|
DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 9| 9| 6| 9| 8| 6| 9| 6| 9| 8| 9| 8| 6| 9|
| 2| 2| 6| 2| 1| 2| 1| 6| 2| 1| 7| 1| 0| 2| 1| 6| 2| 7| 1| 7| 6| 1| 2| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
Ulcer, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | |
Fatty Change | |
Inflammation, Chronic Active | 2 |
Mixed Cell Focus | |
Necrosis | 1 |
Pigmentation, Ceroid | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Atrophy | 1 |
Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Polyarteritis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia | |
Pigmentation, Ceroid | 2 2 2 2 1 2 1 2 |
Subcapsular, Hyperplasia | 1 1 2 1 1 1 1 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 0| 0| 4| 0| 2| 4| 0| 4| 0| 2| 0| 2| 4| 0|
DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 9| 9| 6| 9| 8| 6| 9| 6| 9| 8| 9| 8| 6| 9|
| 2| 2| 6| 2| 1| 2| 1| 6| 2| 1| 7| 1| 0| 2| 1| 6| 2| 7| 1| 7| 6| 1| 2| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + + + M + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
Inflammation | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Cyst | |
Hyperplasia, Cystic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Cystic | 1 2 3 2 2 3 3 |
Lymphatic, Angiectasis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | |
Mediastinal, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 0| 0| 4| 0| 2| 4| 0| 4| 0| 2| 0| 2| 4| 0|
DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 9| 9| 6| 9| 8| 6| 9| 6| 9| 8| 9| 8| 6| 9|
| 2| 2| 6| 2| 1| 2| 1| 6| 2| 1| 7| 1| 0| 2| 1| 6| 2| 7| 1| 7| 6| 1| 2| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + +|
Cyst | |
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + M M + + + + + + + + + + M +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Hydronephrosis | 2|
Infarct | |
Nephropathy | 1 1 1 |
Pigmentation, Hemosiderin | |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 0| 0| 4| 4| 4| 0| 4| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 9| 6| 6| 6| 9| 6| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 8| 3| 3| 3| 3| 3|
| 2| 7| 0| 1| 1| 2| 7| 1| 1| 1| 2| 0| 1| 0| 1| 6| 2| 2| 2| 2| 7| 7| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6|
125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 9| 9| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Ulcer, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | |
Fatty Change | |
Inflammation, Chronic Active | |
Mixed Cell Focus | X |
Necrosis | 1 |
Pigmentation, Ceroid | |
Pigmentation, Hemosiderin | 2|
__________________________________________________________________________|
Mesentery | +|
Inflammation, Chronic Active | 2|
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Polyarteritis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia | |
Pigmentation, Ceroid | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 3 3 3|
Subcapsular, Hyperplasia | 1 2 2 1 2 2 2 1 2 1 2 1 1 1 1 1 2 2 2|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 0| 0| 4| 4| 4| 0| 4| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 9| 6| 6| 6| 9| 6| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 8| 3| 3| 3| 3| 3|
| 2| 7| 0| 1| 1| 2| 7| 1| 1| 1| 2| 0| 1| 0| 1| 6| 2| 2| 2| 2| 7| 7| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6|
125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 9| 9| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + M + + + + M + + M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 4 2 1|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Cyst | X X X|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Cystic | 1 2 2 2 4 2 1 2 3 2 2 2 2 2 2 2|
Lymphatic, Angiectasis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
Myelofibrosis | 1 1 2 |
__________________________________________________________________________|
Lymph Node | +|
Mediastinal, Pigmentation, | |
Hemosiderin | 4|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2|
Hematopoietic Cell Proliferation | 1|
Hyperplasia, Lymphoid | 1 1 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 0| 0| 4| 4| 4| 0| 4| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 9| 6| 6| 6| 9| 6| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 8| 3| 3| 3| 3| 3|
| 2| 7| 0| 1| 1| 2| 7| 1| 1| 1| 2| 0| 1| 0| 1| 6| 2| 2| 2| 2| 7| 7| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6|
125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 9| 9| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | M + + + M + + + + M + M M + + M + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infarct | |
Nephropathy | 1 1 1 1 1 1|
Pigmentation, Hemosiderin | 3|
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | X X X |
Fatty Change | |
Inflammation, Chronic Active | |
Mixed Cell Focus | |
Necrosis | |
Pigmentation, Ceroid | 1 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic Active | |
Fat, Necrosis | 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Polyarteritis | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Artery, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X|
Hyperplasia | 1 1 1 |
Pigmentation, Ceroid | 3 4 2 3 2 2 2 2 2 3 2 4 1 2 3 2 3 2 1 2 3 2 4 4|
Subcapsular, Hyperplasia | 1 1 2 2 2 2 2 2 2 2 2 2 1 1 2 2 2 1 1 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + M + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 1 1 2 2 2 1 3 4 1 3 1 1|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 3 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + M + + + + + + + +|
Angiectasis | |
Atrophy | 4 |
Cyst | X X X X X X X X|
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Cystic | 4 2 4 2 2 2 2 2 1 1 2 2 2 1 4 2 2 2 2|
Lymphatic, Angiectasis | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 4 |
Myelofibrosis | 1 2 2 2 1 2 1 2 1 2 2 1 |
__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Lymphoid | 2 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 1 1 1 1 1 1 1 1 |
Hyperplasia, Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Depletion Lymphoid | |
Hyperplasia, Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Harderian Gland | M + + + + + + M M M M M + M + + M + + M M M M +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infarct | 1 |
Nephropathy | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation, Hemosiderin | |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 7| 3| | |
| 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 1| 3| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + | 77 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + | 77 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + | 77 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + | 78 |
Ulcer, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + | 78 |
Lymphoid Tissue, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + | 77 |
Amyloid Deposition | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + | 78 |
Basophilic Focus | X | 1 |
Eosinophilic Focus | X X | 5 |
Fatty Change | 1 | 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
Mixed Cell Focus | X | 2 |
Necrosis | | 2 1.0|
Pigmentation, Ceroid | | 1 1.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Inflammation, Chronic Active | | 1 2.0|
Fat, Necrosis | 4 | 5 2.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + | 78 |
Atrophy | | 4 1.0|
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + | 78 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + | 78 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Polyarteritis | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + | 78 |
Inflammation, Chronic Active | 2 | 1 2.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 7| 3| | |
| 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 1| 3| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + | 78 |
Accessory Adrenal Cortical Nodule | X | 4 |
Hyperplasia | 1 1 1 1 | 7 1.0|
Pigmentation, Ceroid | 3 2 2 3 2 2 2 2 3 2 2 2 4 2 2 3 2 4 | 67 2.3|
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 | 74 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + | 78 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + | 78 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + + M + + + + + | 76 |
Pars Distalis, Hyperplasia | 1 1 1 1 | 21 1.8|
Pars Intermedia, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + | 78 |
Inflammation | | 1 1.0|
Follicle, Cyst | X | 2 |
Follicular Cell, Hyperplasia | 1 1 1 1 2 2 | 13 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Duct, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + | 77 |
Angiectasis | 2 | 1 2.0|
Atrophy | 4 | 2 4.0|
Cyst | X X X X X | 16 |
Hyperplasia, Cystic | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + | 78 |
Angiectasis | 3 | 2 2.5|
Hyperplasia, Cystic | 2 2 1 2 2 4 2 2 1 3 1 | 53 2.1|
Lymphatic, Angiectasis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + | 78 |
Hyperplasia | 2 | 5 2.8|
Myelofibrosis | 2 2 2 2 1 2 1 2 4 4 1 1 | 27 1.7|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 7| 3| | |
| 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 1| 3| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + | 78 |
Hyperplasia, Lymphoid | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + M + | 75 |
Hyperplasia, Lymphoid | | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + | 78 |
Depletion Lymphoid | | 1 2.0|
Hematopoietic Cell Proliferation | 1 3 1 3 2 1 1 1 | 18 1.3|
Hyperplasia, Lymphoid | | 4 1.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + + + + | 77 |
Cyst | | 1 |
Depletion Lymphoid | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + | 75 |
Hyperplasia, Cystic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + | 78 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + | 78 |
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + | 93 |
Axon, Degeneration | 2 1 | 4 1.3|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + | 93 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + | 78 |
Alveolar Epithelium, Hyperplasia | | 2 1.0|
Artery, Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + | 78 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 7| 3| | |
| 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 1| 3| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + M M + + + + M + M + + + M + + + M | 51 |
Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + | 78 |
Hydronephrosis | | 1 2.0|
Infarct | | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 | 42 1.1|
Pigmentation, Hemosiderin | | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + | 77 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 4| 2| 4| 4| 2| 0| 4| 2| 0| 0| 0| 2| 0| 0| 0| 4| 0| 4| 0| 2| 4| 0| 2| 0|
DAY ON TEST | 8| 6| 8| 6| 6| 8| 9| 6| 8| 9| 9| 9| 8| 9| 9| 7| 6| 9| 6| 9| 8| 6| 9| 8| 9|
| 2| 2| 6| 1| 1| 2| 0| 1| 2| 7| 7| 1| 2| 1| 1| 9| 1| 1| 2| 0| 6| 2| 0| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
Ulcer, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
Lymphoid Tissue, Hyperplasia | |
Lymphoid Tissue, Ulcer, Chronic | |
Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Angiectasis | |
Clear Cell Focus | |
Eosinophilic Focus | |
Fatty Change | |
Mixed Cell Focus | |
Necrosis | 1 |
Pigmentation, Ceroid | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + |
Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + |
Cyst | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + |
Accessory Adrenal Cortical Nodule | |
Hyperplasia | |
Pigmentation, Ceroid | 3 4 4 3 4 3 3 1 4 1 |
Subcapsular, Hyperplasia | 1 2 2 1 1 1 1 1 1 1 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 4| 2| 4| 4| 2| 0| 4| 2| 0| 0| 0| 2| 0| 0| 0| 4| 0| 4| 0| 2| 4| 0| 2| 0|
DAY ON TEST | 8| 6| 8| 6| 6| 8| 9| 6| 8| 9| 9| 9| 8| 9| 9| 7| 6| 9| 6| 9| 8| 6| 9| 8| 9|
| 2| 2| 6| 1| 1| 2| 0| 1| 2| 7| 7| 1| 2| 1| 1| 9| 1| 1| 2| 0| 6| 2| 0| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + M + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + M M + |
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + |
Angiectasis | |
Pars Distalis, Hyperplasia | 2 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
Inflammation | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + |
Angiectasis | |
Atrophy | |
Cyst | X X X |
Periovarian Tissue, Inflammation, | |
Granulomatous | |
Rete Ovarii, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + |
Angiectasis | |
Hyperplasia, Cystic | 3 2 2 3 1 3 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + |
Hyperplasia | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + |
Cyst | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 4| 2| 4| 4| 2| 0| 4| 2| 0| 0| 0| 2| 0| 0| 0| 4| 0| 4| 0| 2| 4| 0| 2| 0|
DAY ON TEST | 8| 6| 8| 6| 6| 8| 9| 6| 8| 9| 9| 9| 8| 9| 9| 7| 6| 9| 6| 9| 8| 6| 9| 8| 9|
| 2| 2| 6| 1| 1| 2| 0| 1| 2| 7| 7| 1| 2| 1| 1| 9| 1| 1| 2| 0| 6| 2| 0| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + |
Cyst | X |
Depletion Lymphoid | 2 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + |
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + |
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + |
Respiratory Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + M + + + + + + M + + + + + M |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Hydronephrosis | |
Infarct | |
Mineralization | |
Nephropathy | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 7| 4| 7| 7| 7|
DAY ON TEST | 6| 9| 6| 9| 6| 6| 6| 9| 8| 6| 8| 8| 6| 9| 8| 8| 8| 8| 8| 9| 3| 7| 3| 3| 3|
| 1| 0| 1| 0| 1| 1| 2| 7| 6| 1| 2| 2| 2| 7| 6| 2| 2| 2| 2| 1| 6| 1| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Ulcer, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia | |
Lymphoid Tissue, Ulcer, Chronic | |
Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | X X|
Eosinophilic Focus | X |
Fatty Change | |
Mixed Cell Focus | |
Necrosis | |
Pigmentation, Ceroid | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia | |
Pigmentation, Ceroid | 4 4 3 3 4 3 3 4 3 3 3 4 4 4 4 4|
Subcapsular, Hyperplasia | 2 1 1 1 2 2 2 2 2 1 1 1 1 1 2 1 1 2 1|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 7| 4| 7| 7| 7|
DAY ON TEST | 6| 9| 6| 9| 6| 6| 6| 9| 8| 6| 8| 8| 6| 9| 8| 8| 8| 8| 8| 9| 3| 7| 3| 3| 3|
| 1| 0| 1| 0| 1| 1| 2| 7| 6| 1| 2| 2| 2| 7| 6| 2| 2| 2| 2| 1| 6| 1| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + + + + M + + + + + + M +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Hyperplasia | 4 1|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Cyst | X X X |
Periovarian Tissue, Inflammation, | |
Granulomatous | |
Rete Ovarii, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Cystic | 2 3 1 2 2 1 1 1 2 1 3 3 4 2|
Thrombosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Lymphoid | 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 7| 4| 7| 7| 7|
DAY ON TEST | 6| 9| 6| 9| 6| 6| 6| 9| 8| 6| 8| 8| 6| 9| 8| 8| 8| 8| 8| 9| 3| 7| 3| 3| 3|
| 1| 0| 1| 0| 1| 1| 2| 7| 6| 1| 2| 2| 2| 7| 6| 2| 2| 2| 2| 1| 6| 1| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 2 1|
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + M + + + +|
Cyst | |
Depletion Lymphoid | 4 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | 1 3 1|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Respiratory Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + M + M + + + M + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 1 |
Infarct | |
Mineralization | 2 |
Nephropathy | 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
250 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Ulcer, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia | |
Lymphoid Tissue, Ulcer, Chronic | |
Active | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Lymphoid Tissue, Hyperplasia | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Clear Cell Focus | X |
Eosinophilic Focus | X X X |
Fatty Change | 1 |
Mixed Cell Focus | X X |
Necrosis | |
Pigmentation, Ceroid | 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic Active | 2 |
Fat, Necrosis | 4 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia | 1 |
Pigmentation, Ceroid | 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Subcapsular, Hyperplasia | 2 2 1 2 1 1 1 1 2 2 1 2 1 2 1 2 1 1 1 2 1 2 2 1 2|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
250 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + M + + M M + + + M + + + M + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 1 |
Pars Distalis, Hyperplasia | 1 2 1 1 4 1 1 2|
Pars Intermedia, Hyperplasia | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Follicle, Cyst | X X X |
Follicular Cell, Hyperplasia | 2 1 2 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Cyst | X X X X X X X X X X |
Periovarian Tissue, Inflammation, | |
Granulomatous | |
Rete Ovarii, Hyperplasia | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Hyperplasia, Cystic | 2 2 2 3 1 2 1 1 3 2 2 1 3 3 2 4 2 1|
Thrombosis | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Myelofibrosis | 1 1 2 1 2 1 1 1 2 1 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + M + + + M + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | 2 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
250 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 3 2 1 1 2 4 1 2 2 1 2 1 1 1|
Hyperplasia, Lymphoid | 1 4 1 1 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + M + + + + + + + +|
Cyst | |
Depletion Lymphoid | 4 |
Hyperplasia, Lymphoid | 4 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | 2 1 1 1 1 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Respiratory Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | M + + + + M + M + M + + + + M M M + + + M + + + M|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infarct | |
Mineralization | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 79 |
Ulcer, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 80 |
Lymphoid Tissue, Hyperplasia | 2 | 1 2.0|
Lymphoid Tissue, Ulcer, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 80 |
Amyloid Deposition | | 1 4.0|
Lymphoid Tissue, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 80 |
Angiectasis | | 1 3.0|
Clear Cell Focus | X | 4 |
Eosinophilic Focus | X X X | 7 |
Fatty Change | | 1 1.0|
Mixed Cell Focus | | 2 |
Necrosis | 2 | 2 1.5|
Pigmentation, Ceroid | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Inflammation, Chronic Active | | 1 2.0|
Fat, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 80 |
Atrophy | 1 | 1 1.0|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 80 |
Accessory Adrenal Cortical Nodule | | 1 |
Hyperplasia | 1 | 2 1.0|
Pigmentation, Ceroid | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 | 71 3.7|
Subcapsular, Hyperplasia | 1 2 1 2 1 2 2 1 2 2 2 1 2 1 1 2 2 2 2 2 | 80 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 78 |
Hyperplasia | | 4 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 67 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 79 |
Angiectasis | | 2 2.5|
Pars Distalis, Hyperplasia | 4 1 4 4 1 1 1 1 | 19 1.9|
Pars Intermedia, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation | 1 | 3 1.3|
Follicle, Cyst | X | 4 |
Follicular Cell, Hyperplasia | 1 2 2 1 3 | 15 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Duct, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + M + + + + + + + + + + + + + + + + + + | 79 |
Angiectasis | 2 | 1 2.0|
Atrophy | 4 | 1 4.0|
Cyst | X X X X X X | 22 |
Periovarian Tissue, Inflammation, | | |
Granulomatous | 4 | 1 4.0|
Rete Ovarii, Hyperplasia | 1 | 2 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 80 |
Angiectasis | 2 | 2 3.0|
Hyperplasia, Cystic | 1 4 1 2 2 4 1 1 1 1 4 1 2 2 2 2 1 4 2 | 57 2.1|
Thrombosis | X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 4 2 4 2 2 | 6 2.7|
Myelofibrosis | 1 1 1 1 1 3 2 1 1 1 2 2 2 1 2 | 26 1.4|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 76 |
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + | 78 |
Cyst | X | 1 |
Hyperplasia, Lymphoid | 2 | 6 2.2|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 80 |
Depletion Lymphoid | | 1 2.0|
Hematopoietic Cell Proliferation | 4 1 2 1 3 1 3 1 2 | 26 1.8|
Hyperplasia, Lymphoid | 3 3 | 8 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + M + + + + + + + + | 74 |
Cyst | | 1 |
Depletion Lymphoid | 2 | 4 3.0|
Hyperplasia, Lymphoid | 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia, Cystic | | 2 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic Active | | 1 1.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 80 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 80 |
Necrosis | 1 1 | 3 1.7|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 95 |
Axon, Degeneration | 1 1 1 | 12 1.3|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 95 |
Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic Active | 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 80 |
Respiratory Epithelium, Inflammation | 2 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 80 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + M + + M M + M + + + + + M + + | 60 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 80 |
Hydronephrosis | | 1 1.0|
Infarct | 1 | 1 1.0|
Mineralization | | 1 2.0|
Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 | 38 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 80 |
Artery, Inflammation, Chronic Active | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 0| 4| 4| 4| 2| 0| 4| 0| 0| 4| 4| 0| 0| 4| 2| 0| 0| 2| 2| 0| 0| 4|
DAY ON TEST | 8| 8| 8| 9| 6| 6| 6| 8| 9| 6| 9| 9| 6| 6| 9| 9| 6| 8| 9| 9| 8| 8| 9| 9| 6|
| 6| 1| 1| 6| 0| 2| 0| 1| 6| 0| 1| 6| 2| 0| 0| 0| 0| 1| 1| 0| 6| 1| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | |
Fatty Change | |
Mixed Cell Focus | |
Necrosis | |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | |
Serosa, Inflammation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
Duct, Hyperplasia | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Polyarteritis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 0| 4| 4| 4| 2| 0| 4| 0| 0| 4| 4| 0| 0| 4| 2| 0| 0| 2| 2| 0| 0| 4|
DAY ON TEST | 8| 8| 8| 9| 6| 6| 6| 8| 9| 6| 9| 9| 6| 6| 9| 9| 6| 8| 9| 9| 8| 8| 9| 9| 6|
| 6| 1| 1| 6| 0| 2| 0| 1| 6| 0| 1| 6| 2| 0| 0| 0| 0| 1| 1| 0| 6| 1| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 1 1 1|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + M + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + |
Inflammation, Suppurative | |
Duct, Dilatation | 3 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
Granuloma | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | |
Inguinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + M + + + + +|
Cyst | |
Hematopoietic Cell Proliferation | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 0| 4| 4| 4| 2| 0| 4| 0| 0| 4| 4| 0| 0| 4| 2| 0| 0| 2| 2| 0| 0| 4|
DAY ON TEST | 8| 8| 8| 9| 6| 6| 6| 8| 9| 6| 9| 9| 6| 6| 9| 9| 6| 8| 9| 9| 8| 8| 9| 9| 6|
| 6| 1| 1| 6| 0| 2| 0| 1| 6| 0| 1| 6| 2| 0| 0| 0| 0| 1| 1| 0| 6| 1| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + +|
Cyst | |
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Abscess | |
Granuloma | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | 3 |
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
Proliferation Connective Tissue | |
Respiratory Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 0| 4| 4| 4| 2| 0| 4| 0| 0| 4| 4| 0| 0| 4| 2| 0| 0| 2| 2| 0| 0| 4|
DAY ON TEST | 8| 8| 8| 9| 6| 6| 6| 8| 9| 6| 9| 9| 6| 6| 9| 9| 6| 8| 9| 9| 8| 8| 9| 9| 6|
| 6| 1| 1| 6| 0| 2| 0| 1| 6| 0| 1| 6| 2| 0| 0| 0| 0| 1| 1| 0| 6| 1| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
Inflammation, Suppurative | |
Nephropathy | 1 1 1 1 2 1 1 1 1|
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 4| 0| 2| 4| 0| 0| 4| 4| 2| 4| 4| 2| 2| 2| 2| 4| 2| 2| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 6| 9| 8| 6| 4| 9| 6| 6| 8| 6| 6| 8| 8| 8| 8| 6| 8| 8| 9| 3| 3| 3| 3| 3|
| 1| 0| 1| 1| 2| 0| 1| 0| 0| 1| 2| 0| 1| 1| 6| 6| 2| 1| 6| 6| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 9| 9| 9| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | X X|
Fatty Change | 2 |
Mixed Cell Focus | |
Necrosis | |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | |
Serosa, Inflammation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
Duct, Hyperplasia | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Polyarteritis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 4| 0| 2| 4| 0| 0| 4| 4| 2| 4| 4| 2| 2| 2| 2| 4| 2| 2| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 6| 9| 8| 6| 4| 9| 6| 6| 8| 6| 6| 8| 8| 8| 8| 6| 8| 8| 9| 3| 3| 3| 3| 3|
| 1| 0| 1| 1| 2| 0| 1| 0| 0| 1| 2| 0| 1| 1| 6| 6| 2| 1| 6| 6| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 9| 9| 9| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 1 1|
Pigmentation, Ceroid | 1 1 2 2 1 1 1 1 1 1 1 1 1 1|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M M + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Cyst | X |
Pars Distalis, Hyperplasia | 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + +|
Inflammation, Suppurative | 2|
Duct, Dilatation | 4 4 4 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
Granuloma | |
Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | |
Inguinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + M + + + +|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + M|
Cyst | |
Hematopoietic Cell Proliferation | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 4| 0| 2| 4| 0| 0| 4| 4| 2| 4| 4| 2| 2| 2| 2| 4| 2| 2| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 6| 9| 8| 6| 4| 9| 6| 6| 8| 6| 6| 8| 8| 8| 8| 6| 8| 8| 9| 3| 3| 3| 3| 3|
| 1| 0| 1| 1| 2| 0| 1| 0| 0| 1| 2| 0| 1| 1| 6| 6| 2| 1| 6| 6| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 9| 9| 9| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M +|
Cyst | X |
Depletion Lymphoid | 4 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M + + + M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Abscess | |
Granuloma | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | |
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Pigmentation, Hemosiderin | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Proliferation Connective Tissue | |
Respiratory Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 4| 0| 2| 4| 0| 0| 4| 4| 2| 4| 4| 2| 2| 2| 2| 4| 2| 2| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 6| 9| 8| 6| 4| 9| 6| 6| 8| 6| 6| 8| 8| 8| 8| 6| 8| 8| 9| 3| 3| 3| 3| 3|
| 1| 0| 1| 1| 2| 0| 1| 0| 0| 1| 2| 0| 1| 1| 6| 6| 2| 1| 6| 6| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 9| 9| 9| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
Inflammation, Suppurative | |
Nephropathy | 1 1 1 1 1 1 1 1 3 2|
Artery, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 4| 6| 2| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 2| 4|
| 9| 9| 9| 3| 0| 0| 0| 0| 0| 0| 0| 8| 5| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | |
Clear Cell Focus | X X |
Eosinophilic Focus | X X X X |
Fatty Change | 2|
Mixed Cell Focus | X |
Necrosis | 2 |
Vacuolization Cytoplasmic, Focal | 2 |
Bile Duct, Hyperplasia | 2 |
Serosa, Inflammation | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Hyperplasia | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Hyperplasia | |
__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Polyarteritis | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 4| 6| 2| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 2| 4|
| 9| 9| 9| 3| 0| 0| 0| 0| 0| 0| 0| 8| 5| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 1 2 1 1 1 1 1 1 1 2 3 1|
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Duct, Dilatation | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node | |
Inguinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 1 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hematopoietic Cell Proliferation | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 4| 6| 2| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 2| 4|
| 9| 9| 9| 3| 0| 0| 0| 0| 0| 0| 0| 8| 5| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 1 2 3 |
Hematopoietic Cell Proliferation | 2 1 1 3 3 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + M + + + + + + + + M + M +|
Cyst | |
Depletion Lymphoid | 2 4 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M + M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Granuloma | |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | |
Necrosis | 1 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | 1 3 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Proliferation Connective Tissue | |
Respiratory Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation | |
__________________________________________________________________________|
Harderian Gland | + M + M + M + + + + M + M + + + + + + + + + + M +|
Hyperplasia | 1 3 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 4| 6| 2| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 2| 4|
| 9| 9| 9| 3| 0| 0| 0| 0| 0| 0| 0| 8| 5| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | 1 |
Inflammation, Suppurative | 1 2 |
Nephropathy | 2 2 1 1 2 1 1 1 1 1 1 1 1 4 1 1 1 1 1 2 4 1|
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| | |
| 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + | 78 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 80 |
Angiectasis | | 1 1.0|
Basophilic Focus | X | 1 |
Clear Cell Focus | X X X | 5 |
Eosinophilic Focus | X | 7 |
Fatty Change | 1 1 1 2 1 | 7 1.4|
Mixed Cell Focus | | 1 |
Necrosis | 2 | 2 2.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Bile Duct, Hyperplasia | | 1 2.0|
Serosa, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 80 |
Atrophy | 1 3 | 3 2.7|
Cyst | | 1 |
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 80 |
Duct, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 |
Erosion | | 1 1.0|
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + | 3 |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Polyarteritis | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| | |
| 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 80 |
Accessory Adrenal Cortical Nodule | | 2 |
Hyperplasia | 1 1 1 1 1 2 1 1 2 1 | 26 1.2|
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 68 1.0|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 62 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 79 |
Hyperplasia | 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 1 2 1 | 9 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 74 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + | 78 |
Cyst | X X X | 4 |
Pars Distalis, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 80 |
Atrophy | 3 | 1 3.0|
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + | 45 |
Inflammation, Suppurative | 2 3 3 2 | 6 2.5|
Duct, Dilatation | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 | 44 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 80 |
Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| | |
| 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Granuloma | 1 | 1 1.0|
Hyperplasia | 2 2 2 3 | 7 2.4|
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Inguinal, Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 78 |
Depletion Lymphoid | | 1 1.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 76 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 80 |
Depletion Lymphoid | 1 | 5 1.8|
Hematopoietic Cell Proliferation | 3 3 1 1 4 2 1 4 | 15 2.3|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M + + M + + | 73 |
Cyst | | 1 |
Depletion Lymphoid | 2 | 4 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M + M M M M M M M M M M M M M M | 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 80 |
Abscess | | 1 3.0|
Granuloma | 3 | 1 3.0|
Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 80 |
Infiltration Cellular, Lipocyte | | 1 3.0|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 95 |
Axon, Degeneration | 1 1 | 4 1.5|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 95 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| | |
| 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic Active | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 1 1 | 3 1.7|
Alveolus, Pigmentation, Hemosiderin | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 80 |
Proliferation Connective Tissue | 3 | 1 3.0|
Respiratory Epithelium, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 80 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + M M + + + + + + + M + | 71 |
Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst | X X | 2 |
Infarct | 1 | 2 1.0|
Inflammation, Suppurative | | 2 1.5|
Nephropathy | 1 1 1 3 1 1 1 1 1 1 2 1 1 1 4 2 2 2 1 1 | 61 1.4|
Artery, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Suppurative | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 4| 0| 2| 0| 4| 0| 4| 2| 0| 2| 0| 4| 0| 2|
DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 6| 9| 8| 9| 6| 9| 6| 8| 9| 8| 9| 6| 9| 8|
| 1| 1| 6| 2| 0| 1| 1| 6| 1| 1| 0| 2| 6| 6| 0| 2| 0| 0| 6| 1| 1| 1| 0| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + +|
Thrombosis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | X |
Fatty Change | 1 |
Hematopoietic Cell Proliferation | |
Necrosis | |
Bile Duct, Cyst | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia | |
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 1 1 1|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 4| 0| 2| 0| 4| 0| 4| 2| 0| 2| 0| 4| 0| 2|
DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 6| 9| 8| 9| 6| 9| 6| 8| 9| 8| 9| 6| 9| 8|
| 1| 1| 6| 2| 0| 1| 1| 6| 1| 1| 0| 2| 6| 6| 0| 2| 0| 0| 6| 1| 1| 1| 0| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + |
Inflammation, Suppurative | |
Duct, Dilatation | 4 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Hematocyst | |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M + M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 4| 0| 2| 0| 4| 0| 4| 2| 0| 2| 0| 4| 0| 2|
DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 8| 9| 9| 6| 9| 8| 9| 6| 9| 6| 8| 9| 8| 9| 6| 9| 8|
| 1| 1| 6| 2| 0| 1| 1| 6| 1| 1| 0| 2| 6| 6| 0| 2| 0| 0| 6| 1| 1| 1| 0| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 4| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 6| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 9| 8| 3| 3| 3| 3| 3|
| 6| 0| 6| 0| 2| 0| 6| 0| 0| 1| 1| 0| 0| 0| 6| 1| 1| 2| 0| 1| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 4| 4| 4|
60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + M M +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X |
Eosinophilic Focus | X |
Fatty Change | 2 2 1 |
Hematopoietic Cell Proliferation | |
Necrosis | |
Bile Duct, Cyst | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia | 1 1 |
Pigmentation, Ceroid | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + M + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 4| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 6| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 9| 8| 3| 3| 3| 3| 3|
| 6| 0| 6| 0| 2| 0| 6| 0| 0| 1| 1| 0| 0| 0| 6| 1| 1| 2| 0| 1| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 4| 4| 4|
60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Inflammation, Suppurative | |
Duct, Dilatation | 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Hematocyst | |
Hematopoietic Cell Proliferation | 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M + M M M M M M M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 4| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 6| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 9| 8| 3| 3| 3| 3| 3|
| 6| 0| 6| 0| 2| 0| 6| 0| 0| 1| 1| 0| 0| 0| 6| 1| 1| 2| 0| 1| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 4| 4| 4|
60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation | |
__________________________________________________________________________|
Harderian Gland | + M + M M + + M M M + + + M + + M + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 2 1 1 1 1 1 1 1 1 1 2 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 7| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X |
Eosinophilic Focus | X |
Fatty Change | 1 1 1 1 1 1 |
Hematopoietic Cell Proliferation | |
Necrosis | |
Bile Duct, Cyst | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Tooth | + + |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia | 1 1 1 3 1 1 2 1 2 1 1 1 |
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Subcapsular, Hyperplasia | 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 1 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + M + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 7| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | 2 2 |
Duct, Dilatation | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 4 2 2 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematocyst | X |
Hematopoietic Cell Proliferation | 1 1 2 3 3 1 4 3 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + M + + M + + + + + + + M +|
Depletion Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M + M M + + + M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 7| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
60 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Axon, Degeneration | 2 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 4 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + M + + + + + + + + + + + + + + + + M + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Nephropathy | 2 1 1 2 1 1 2 3 1 1 2 1 1 1 1 1 1 2 1 1 2 2 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 8| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| | |
| 9| 7| 1| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Gallbladder | M M + + + + + + + + + + + + + + + + + + | 77 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 77 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 79 |
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 79 |
Basophilic Focus | X | 3 |
Clear Cell Focus | X X X | 9 |
Eosinophilic Focus | X | 4 |
Fatty Change | 2 1 1 | 13 1.2|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Necrosis | 1 2 | 2 1.5|
Bile Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 79 |
Atrophy | | 5 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 79 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 79 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 3 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 79 |
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 79 |
Accessory Adrenal Cortical Nodule | | 2 |
Hyperplasia | 2 1 2 3 1 1 1 1 2 | 23 1.4|
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 70 1.0|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 | 64 1.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 79 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 8| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| | |
| 9| 7| 1| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 79 |
Hyperplasia | 4 1 2 1 | 11 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + M + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 79 |
Cyst | X X | 2 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 79 |
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + | 39 |
Inflammation, Suppurative | 3 3 | 4 2.5|
Duct, Dilatation | 4 4 4 4 4 4 4 3 4 4 4 4 | 38 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 79 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 79 |
Hyperplasia | 2 2 2 2 | 10 2.4|
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + M + + + + + | 75 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + M + + + + | 76 |
Hematopoietic Cell Proliferation | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 79 |
Hematocyst | | 1 |
Hematopoietic Cell Proliferation | 3 2 2 4 3 4 2 | 19 2.4|
__________________________________________________________________________|____________|
Thymus | + + M M + + + + + + + + + + + M + + + + | 72 |
Depletion Lymphoid | 3 | 3 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M + M M M M M M M + M M | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 79 |
Cyst Epithelial Inclusion | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 8| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| | |
| 9| 7| 1| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
60 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 1 | 1 1.0|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 79 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 79 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 94 |
Axon, Degeneration | | 2 1.5|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 94 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 79 |
Alveolar Epithelium, Hyperplasia | 1 1 | 5 2.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 79 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | M + + + M + + + M + M + + + M + + + M + | 63 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 79 |
Cyst | X | 5 |
Nephropathy | 2 3 1 2 2 1 2 1 1 1 1 1 2 1 1 2 2 1 | 62 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 4| 4| 0| 2| 2| 0| 4| 0| 2| 0| 4| 2| 2| 2| 0| 0| 2| 0| 4| 0| 2|
DAY ON TEST | 8| 8| 8| 8| 6| 6| 9| 8| 8| 9| 6| 9| 8| 9| 6| 8| 8| 8| 9| 9| 8| 9| 6| 9| 8|
| 1| 1| 1| 6| 0| 0| 0| 1| 1| 1| 0| 1| 1| 6| 0| 6| 1| 6| 1| 6| 1| 6| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
125 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Fatty Change | 1 2 |
Mixed Cell Focus | |
Necrosis | 1 |
Pigmentation, Ceroid | 1 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + |
Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + |
Accessory Adrenal Cortical Nodule | X |
Hyperplasia | 1 2 |
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + |
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 4| 4| 0| 2| 2| 0| 4| 0| 2| 0| 4| 2| 2| 2| 0| 0| 2| 0| 4| 0| 2|
DAY ON TEST | 8| 8| 8| 8| 6| 6| 9| 8| 8| 9| 6| 9| 8| 9| 6| 8| 8| 8| 9| 9| 8| 9| 6| 9| 8|
| 1| 1| 1| 6| 0| 0| 0| 1| 1| 1| 0| 1| 1| 6| 0| 6| 1| 6| 1| 6| 1| 6| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
125 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + |
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + |
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
Duct, Dilatation | 4 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + |
Dilatation | |
Hemorrhage, Acute | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + |
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + |
Hyperplasia | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Angiectasis | |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + |
Depletion Lymphoid | |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M + M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 4| 4| 0| 2| 2| 0| 4| 0| 2| 0| 4| 2| 2| 2| 0| 0| 2| 0| 4| 0| 2|
DAY ON TEST | 8| 8| 8| 8| 6| 6| 9| 8| 8| 9| 6| 9| 8| 9| 6| 8| 8| 8| 9| 9| 8| 9| 6| 9| 8|
| 1| 1| 1| 6| 0| 0| 0| 1| 1| 1| 0| 1| 1| 6| 0| 6| 1| 6| 1| 6| 1| 6| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
125 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + |
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + |
Nasolacrimal Duct, Inflammation | |
Respiratory Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Cyst | |
Hydronephrosis | |
Infarct | |
Nephropathy | 2 2 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 0| 2| 4| 2| 4| 0| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 9| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 9| 8| 6| 8| 6| 9| 6| 3| 3| 3| 3| 6|
| 0| 1| 2| 0| 0| 6| 0| 2| 1| 0| 0| 1| 2| 0| 1| 0| 6| 0| 0| 2| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4|
125 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 9| 9| 9| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X |
Eosinophilic Focus | |
Fatty Change | 2 2 2 1 1 |
Mixed Cell Focus | |
Necrosis | |
Pigmentation, Ceroid | 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia | 1 2 1 1 |
Pigmentation, Ceroid | 1 1 1 1 2 1 1 1 1 1 2 1 1 1 2|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + M + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 0| 2| 4| 2| 4| 0| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 9| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 9| 8| 6| 8| 6| 9| 6| 3| 3| 3| 3| 6|
| 0| 1| 2| 0| 0| 6| 0| 2| 1| 0| 0| 1| 2| 0| 1| 0| 6| 0| 0| 2| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4|
125 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 9| 9| 9| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + +|
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
Duct, Dilatation | 4 4 4 4 4 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage, Acute | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 1 |
Hyperplasia, Lymphoid | 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + I + + + + + + +|
Depletion Lymphoid | 4|
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M M M + M M + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 0| 2| 4| 2| 4| 0| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 9| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 9| 8| 6| 8| 6| 9| 6| 3| 3| 3| 3| 6|
| 0| 1| 2| 0| 0| 6| 0| 2| 1| 0| 0| 1| 2| 0| 1| 0| 6| 0| 0| 2| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4|
125 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 9| 9| 9| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | |
Bronchiole, Hyperplasia | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | |
Respiratory Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + I + + M + + M +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | |
Infarct | |
Nephropathy | 1 1 1 1 1 1 2 1 1 2 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 7| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X X X X X X X|
Eosinophilic Focus | X X X|
Fatty Change | 1 2 1 1 1 2 1 1 1 1 1 2|
Mixed Cell Focus | X |
Necrosis | 2 4 |
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | +|
Inflammation, Chronic Active | 1|
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 4 |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 |
Mineralization | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia | 1 1 1 1 2 1 2 1 1 4 1 1 1 1 |
Pigmentation, Ceroid | 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Subcapsular, Hyperplasia | 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 3 1 2 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + + + M + + + + + + + + M + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + M + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 7| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Inflammation, Suppurative | 4 4|
Duct, Dilatation | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage, Acute | |
Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 2 |
Myelofibrosis | 1|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + M + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Depletion Lymphoid | 2 1 3 |
Hematopoietic Cell Proliferation | 2 4 1 2 1 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + M + + + M + + + + + + + M + + + + + + + + + +|
Depletion Lymphoid | 2 4 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M + M M M M M + M M + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 7| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
125 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | 1 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | 2 |
Respiratory Epithelium, Inflammation | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + M M + M + M + + + M M + + + M + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hydronephrosis | |
Infarct | |
Nephropathy | 1 2 2 2 2 2 1 2 1 2 2 2 1 1 1 1 1 1 1 2 2 1 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 8| 8| 8| 8| 4| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + | 76 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + | 79 |
Basophilic Focus | X | 5 |
Clear Cell Focus | X X X X X X X | 18 |
Eosinophilic Focus | X X X X X X | 10 |
Fatty Change | 1 1 1 2 2 1 1 1 2 | 28 1.4|
Mixed Cell Focus | X | 2 |
Necrosis | | 3 2.3|
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 2 1 1 1 1 | 34 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Chronic Active | | 1 1.0|
Fat, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + | 79 |
Atrophy | | 3 2.0|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + | 79 |
Inflammation, Chronic Active | 1 | 3 1.3|
Mineralization | | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + | 79 |
Accessory Adrenal Cortical Nodule | X | 3 |
Hyperplasia | 1 1 1 1 1 1 3 1 1 1 1 | 31 1.3|
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 | 72 1.1|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 | 64 1.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 8| 8| 8| 8| 4| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + | 79 |
Hyperplasia | 1 1 2 3 | 10 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + M + + + | 71 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + | 74 |
Pars Distalis, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + | 79 |
Follicle, Cyst | X | 1 |
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + | 79 |
Granuloma Sperm | 2 3 2 | 4 2.3|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + | 46 |
Inflammation, Granulomatous | 3 | 1 3.0|
Inflammation, Suppurative | 2 | 3 3.3|
Duct, Dilatation | 4 4 4 4 3 4 4 4 4 2 4 4 4 4 4 4 | 45 3.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + | 79 |
Dilatation | 4 | 1 4.0|
Hemorrhage, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + | 79 |
Atrophy | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + | 79 |
Hyperplasia | 2 1 2 | 9 1.6|
Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M M + + + M + + + + + + + + | 73 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + | 76 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + | 79 |
Angiectasis | | 2 2.5|
Depletion Lymphoid | 3 | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 8| 8| 8| 8| 4| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 2 1 1 1 1 3 | 15 1.8|
Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + + + + + + | 74 |
Depletion Lymphoid | | 3 3.3|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M + M M M M + M M M M M M | 9 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + | 79 |
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + | 79 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + | 79 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + | 94 |
Axon, Degeneration | 1 | 3 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + | 94 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + | 79 |
Inflammation, Chronic Active | 1 | 6 1.2|
Thrombosis | | 1 |
Alveolar Epithelium, Hyperplasia | 3 2 | 2 2.5|
Bronchiole, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + | 79 |
Nasolacrimal Duct, Inflammation | | 1 2.0|
Respiratory Epithelium, Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + | 79 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | M + + M + + + + + + + M + + + + + + + | 66 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + | 79 |
Cyst | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 8| 8| 8| 8| 4| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hydronephrosis | 1 | 1 1.0|
Infarct | 1 | 1 1.0|
Nephropathy | 1 1 1 1 2 1 1 1 1 2 2 2 2 1 1 1 2 2 1 | 62 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| 2| 0| 2| 0| 2| 0| 4| 0| 0| 2| 4| 4| 2| 0| 0| 2| 0| 4| 2| 0|
DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 9| 8| 9| 6| 9| 9| 8| 6| 6| 8| 9| 9| 8| 9| 6| 8| 9|
| 1| 1| 6| 2| 0| 1| 1| 6| 0| 1| 0| 2| 6| 0| 6| 2| 0| 6| 0| 1| 1| 1| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
Serosa, Fibrosis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Clear Cell Focus | |
Eosinophilic Focus | |
Erythrophagocytosis | |
Fatty Change | 2 2 1 |
Necrosis | 1 2 |
Pigmentation, Ceroid | 1 1 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + |
Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + |
Erosion | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + |
Accessory Adrenal Cortical Nodule | |
Hyperplasia | |
Pigmentation, Ceroid | 2 2 1 2 1 1 1 1 1 1 2 1 1 2 |
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| 2| 0| 2| 0| 2| 0| 4| 0| 0| 2| 4| 4| 2| 0| 0| 2| 0| 4| 2| 0|
DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 9| 8| 9| 6| 9| 9| 8| 6| 6| 8| 9| 9| 8| 9| 6| 8| 9|
| 1| 1| 6| 2| 0| 1| 1| 6| 0| 1| 0| 2| 6| 0| 6| 2| 0| 6| 0| 1| 1| 1| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Preputial Gland | |
Atrophy | |
Inflammation, Suppurative | |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + |
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + |
Granuloma | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Angiectasis | |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + |
Atrophy | |
Depletion Lymphoid | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| 2| 0| 2| 0| 2| 0| 4| 0| 0| 2| 4| 4| 2| 0| 0| 2| 0| 4| 2| 0|
DAY ON TEST | 8| 8| 8| 6| 6| 8| 9| 8| 9| 8| 9| 6| 9| 9| 8| 6| 6| 8| 9| 9| 8| 9| 6| 8| 9|
| 1| 1| 6| 2| 0| 1| 1| 6| 0| 1| 0| 2| 6| 0| 6| 2| 0| 6| 0| 1| 1| 1| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Alveolar Epithelium, Hyperplasia | |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + |
Developmental Malformation | |
Nasolacrimal Duct, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | M + + + + + + + M M + + + + + + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Cyst | |
Hydronephrosis | |
Infarct | |
Nephropathy | 1 1 1 1 |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 4| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 6| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 9| 8| 3| 3| 3| 3| 3|
| 6| 0| 6| 0| 2| 0| 6| 0| 0| 1| 0| 0| 1| 0| 6| 1| 1| 2| 1| 1| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5|
250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Serosa, Fibrosis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Eosinophilic Focus | |
Erythrophagocytosis | |
Fatty Change | 2 2 1 1|
Necrosis | |
Pigmentation, Ceroid | 1 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X |
Hyperplasia | 2 2 |
Pigmentation, Ceroid | 2 1 2 1 2 1 1 1 2 1 1 1 1 1 1 2 2|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 4| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 6| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 9| 8| 3| 3| 3| 3| 3|
| 6| 0| 6| 0| 2| 0| 6| 0| 0| 1| 0| 0| 1| 0| 6| 1| 1| 2| 1| 1| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5|
250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Atrophy | |
Inflammation, Suppurative | |
Duct, Dilatation | 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Hyperplasia | 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 3 4|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Depletion Lymphoid | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + M M M + M + M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 0| 4| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 4| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 6| 9| 6| 6| 6| 9| 6| 6| 8| 9| 6| 9| 6| 8| 8| 8| 6| 9| 8| 3| 3| 3| 3| 3|
| 6| 0| 6| 0| 2| 0| 6| 0| 0| 1| 0| 0| 1| 0| 6| 1| 1| 2| 1| 1| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5|
250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Bronchiole, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Nasolacrimal Duct, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | M + + M + M + + + M + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | |
Infarct | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3|
| 6| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
250 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X X X |
Eosinophilic Focus | X |
Erythrophagocytosis | |
Fatty Change | 1 1 2 2 2 3 3 3 1|
Necrosis | 2 |
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 1 1 1 2 2 1|
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 2 1 1 1|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + M + M + + + +|
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3|
| 6| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
250 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst | X X|
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 2 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Suppurative | 2 2 |
Duct, Dilatation | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | 2|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M M + + + + M + + + +|
Hematopoietic Cell Proliferation | 1 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + M + + + + + + + + + + + + + + + M + + + +|
Hematopoietic Cell Proliferation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + M + + + +|
Angiectasis | |
Depletion Lymphoid | 4 |
Hematopoietic Cell Proliferation | 1 1 3 3 2 3 2 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + M + +|
Atrophy | 4 |
Depletion Lymphoid | 4 4 2 3 2 |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M + M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3|
| 6| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
250 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 1 |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Nasolacrimal Duct, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + M + + + + + + + + M + + + + M + M + M +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | |
Infarct | 3 |
Nephropathy | 1 1 1 1 1 1 1 1 2 2 1 2 1 1 1 1 1 1 1 1 1 3 1|
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 6| 8| 6| 7| 6| 6| 6| 6| 6| 6| 7| 2| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + | 75 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 80 |
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 80 |
Clear Cell Focus | X X X X X X X | 12 |
Eosinophilic Focus | X X X X | 5 |
Erythrophagocytosis | 2 | 1 2.0|
Fatty Change | 3 2 2 3 2 2 2 2 1 2 2 | 27 1.9|
Necrosis | 1 | 4 1.5|
Pigmentation, Ceroid | 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.1|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | 1 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 80 |
Atrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 |
Erosion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 80 |
Accessory Adrenal Cortical Nodule | X | 4 |
Hyperplasia | 1 3 1 1 1 1 1 1 1 1 1 | 26 1.2|
Pigmentation, Ceroid | 1 1 1 2 1 1 1 1 2 1 1 1 2 1 1 1 1 1 2 1 | 75 1.2|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 | 61 1.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 78 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 6| 8| 6| 7| 6| 6| 6| 6| 6| 6| 7| 2| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 2 2 1 1 1 1 4 | 15 1.4|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + M + M + + M + + + + | 72 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + | 74 |
Cyst | X X | 4 |
Pars Distalis, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Granulomatous | | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + | 45 |
Atrophy | 4 | 1 4.0|
Inflammation, Suppurative | 2 | 3 2.0|
Duct, Dilatation | 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 | 44 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 80 |
Atrophy | 2 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 |
Granuloma | | 1 2.0|
Hyperplasia | 4 3 2 2 | 8 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + | 75 |
Hematopoietic Cell Proliferation | | 2 1.5|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 76 |
Hematopoietic Cell Proliferation | 1 | 2 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 79 |
Angiectasis | 2 | 1 2.0|
Depletion Lymphoid | 3 | 2 3.5|
Hematopoietic Cell Proliferation | 4 4 1 1 3 2 3 2 | 18 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 6| 8| 6| 7| 6| 6| 6| 6| 6| 6| 7| 2| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + M + + + + + + + M + + + | 75 |
Atrophy | 4 | 2 4.0|
Depletion Lymphoid | 4 3 4 2 | 9 3.1|
Epithelial Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M M M M + M M M M M M M M M M M M | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst Epithelial Inclusion | X | 1 |
Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 95 |
Axon, Degeneration | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 95 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 80 |
Alveolar Epithelium, Hyperplasia | 1 | 2 1.0|
Bronchiole, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 80 |
Developmental Malformation | | 1 |
Nasolacrimal Duct, Inflammation | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 80 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + M + + + + + + M + + M M + + M M + M M | 60 |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05100-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/23/97
Route: DOSED FEED Time: 14:54:11
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 6| 8| 6| 7| 6| 6| 6| 6| 6| 6| 7| 2| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
250 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst | X | 1 |
Hydronephrosis | 2 | 1 2.0|
Infarct | | 1 3.0|
Nephropathy | 2 3 1 1 1 1 1 1 1 1 4 1 1 1 1 2 1 | 59 1.2|
Renal Tubule, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + | 79 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
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---------- END OF REPORT ----------
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