TDMS Study 05100-03 Pathology Tables
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:06:56
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1330-78-5
Lock Date: 12/30/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:06:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 95 95 95 95 95
Scheduled Sacrifice 44 42 45 44 94
Early Deaths
Natural Death 3 3 5 5
Moribund Sacrifice 14 12 15 18 1
Accidently Killed 1
Survivors
Natural Death 1
Terminal Sacrifice 34 37 30 26
Missing 1
Animals Examined Microscopically 95 95 95 94 45
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (80) (81) (79) (80) (30)
Parasite Metazoan 3 (4%) 1 (1%) 1 (3%)
Ulcer 1 (1%)
Intestine Large, Rectum (80) (81) (78) (80) (30)
Fibrosis 1 (1%)
Inflammation, Necrotizing 1 (1%)
Parasite Metazoan 2 (3%) 1 (1%) 6 (8%)
Intestine Large, Cecum (80) (81) (80) (80) (30)
Ulcer 1 (1%)
Intestine Small, Jejunum (79) (80) (78) (77) (30)
Ulcer 1 (1%)
Peyer's Patch, Mineralization 1 (1%)
Intestine Small, Ileum (80) (81) (78) (78) (30)
Ulcer 1 (1%)
Liver (80) (81) (80) (80) (30)
Basophilic Focus 21 (26%) 21 (26%) 25 (31%) 23 (29%) 1 (3%)
Clear Cell Focus 1 (1%) 1 (1%)
Cyst 2 (3%)
Degeneration, Cystic 1 (1%) 1 (1%) 1 (1%)
Degeneration, Fatty 1 (1%)
Eosinophilic Focus 3 (4%) 3 (4%) 3 (4%) 7 (9%)
Fatty Change 2 (2%) 2 (3%) 2 (3%)
Hepatodiaphragmatic Nodule 7 (9%) 11 (14%) 4 (5%) 7 (9%) 3 (10%)
Hyperplasia 1 (1%)
Inflammation, Granulomatous 2 (3%) 6 (7%) 2 (3%) 3 (4%) 1 (3%)
Mixed Cell Focus 5 (6%) 4 (5%) 5 (6%) 4 (5%)
Pigmentation, Hemosiderin 1 (1%)
Serosa, Inflammation, Chronic 1 (1%)
Mesentery (4) (7) (4) (4) (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:06:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hemorrhage 1 (25%)
Fat, Necrosis 4 (100%) 5 (71%) 4 (100%) 3 (75%) 1 (100%)
Pancreas (80) (81) (80) (80) (30)
Inflammation, Chronic 3 (4%) 1 (1%)
Acinus, Atrophy 17 (21%) 12 (15%) 22 (28%) 14 (18%)
Salivary Glands (80) (81) (79) (80) (30)
Inflammation, Chronic 1 (1%)
Stomach, Forestomach (80) (81) (79) (80) (30)
Cyst Epithelial Inclusion 1 (1%)
Ulcer 1 (1%) 1 (1%)
Epithelium, Hyperplasia 1 (1%) 2 (3%) 4 (5%)
Stomach, Glandular (80) (81) (80) (80) (30)
Ulcer 1 (1%) 2 (3%) 1 (1%)
Mucosa, Mineralization 2 (2%) 1 (1%)
Tongue (1)
Mucosa, Epithelium, Hyperplasia 1 (100%)
Tooth (1) (1)
Peridontal Tissue, Inflammation, Chronic
Active 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (80) (81) (80) (80) (30)
Degeneration 1 (1%) 1 (1%) 3 (4%)
Artery, Inflammation, Chronic 1 (1%)
Myocardium, Degeneration 37 (46%) 36 (44%) 37 (46%) 33 (41%) 1 (3%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (80) (81) (80) (80) (29)
Hyperplasia 18 (23%) 14 (17%) 18 (23%) 22 (28%) 3 (10%)
Mineralization 1 (1%)
Vacuolization Cytoplasmic 15 (19%) 12 (15%) 20 (25%) 66 (83%) 9 (31%)
Adrenal Medulla (80) (81) (80) (80) (29)
Hyperplasia 6 (8%) 1 (1%) 2 (3%)
Infarct 1 (1%)
Pituitary Gland (80) (81) (80) (80) (30)
Cyst 1 (1%) 5 (6%) 5 (6%) 5 (6%)
Inflammation, Chronic 1 (1%)
Pigmentation, Hemosiderin 1 (1%)
Pars Distalis, Cyst 1 (1%) 2 (3%) 1 (1%) 1 (3%)
Pars Distalis, Hyperplasia 3 (4%) 6 (7%) 7 (9%) 4 (5%) 2 (7%)
Thyroid Gland (80) (81) (80) (80) (30)
C-Cell, Hyperplasia 37 (46%) 44 (54%) 52 (65%) 39 (49%) 8 (27%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:06:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (80) (81) (79) (79) (30)
Abscess 1 (1%)
Hyperplasia 5 (6%) 2 (2%)
Inflammation, Chronic 5 (6%) 5 (6%) 5 (6%) 3 (4%) 1 (3%)
Inflammation, Chronic Active 1 (1%) 2 (2%) 1 (1%) 4 (5%) 2 (7%)
Ovary (80) (81) (80) (80) (30)
Cyst 3 (4%) 6 (7%) 1 (1%) 5 (6%)
Follicle, Cyst 1 (1%)
Interstitium, Hyperplasia 10 (13%) 44 (55%) 14 (47%)
Uterus (80) (81) (80) (80) (30)
Dilatation 2 (3%) 1 (1%) 5 (6%) 1 (3%)
Prolapse 2 (3%)
Cervix, Cyst 2 (2%) 1 (1%)
Endometrium, Hyperplasia 7 (9%) 6 (7%) 1 (1%) 1 (1%)
Wall, Hyperplasia 1 (1%) 1 (1%)
Vagina (1)
Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (1) (1)
Anisocytosis 1 (100%)
Polychromasia 1 (100%)
Bone Marrow (80) (81) (80) (80) (30)
Atrophy 1 (1%)
Lymph Node, Mandibular (80) (81) (78) (80) (30)
Hyperplasia, Lymphoid 1 (1%)
Spleen (79) (81) (80) (80) (30)
Congestion 1 (1%)
Depletion Lymphoid 1 (1%)
Erythrophagocytosis 1 (1%)
Fibrosis 1 (1%) 2 (2%)
Inflammation, Granulomatous 1 (1%) 3 (4%) 1 (1%)
Pigmentation, Hemosiderin 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:06:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (77) (81) (79) (79) (30)
Hyperplasia, Cystic 1 (1%) 3 (4%) 1 (1%) 1 (1%) 1 (3%)
Skin (80) (81) (80) (80) (30)
Abscess 1 (1%) 1 (1%)
Inflammation, Chronic 1 (1%) 2 (3%) 1 (3%)
Ulcer 1 (3%)
Subcutaneous Tissue, Edema 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (80) (81) (80) (80) (29)
Osteopetrosis 1 (1%) 2 (3%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (80) (81) (80) (80) (30)
Gliosis 1 (1%)
Hypothalamus, Compression 13 (16%) 5 (6%) 6 (8%) 12 (15%)
Spinal Cord (95) (93) (95) (94) (45)
Cyst 2 (2%) 2 (2%)
Axon, Degeneration 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (80) (81) (80) (80) (30)
Inflammation, Chronic 5 (6%) 6 (7%) 2 (3%) 1 (1%)
Fat, Mediastinum, Necrosis 1 (1%)
Nose (80) (81) (80) (80) (30)
Hemorrhage 1 (1%)
Inflammation, Necrotizing 1 (1%)
Inflammation, Suppurative 2 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (5) (2)
Hemorrhage 1 (20%)
Synechia 1 (50%)
Cornea, Inflammation, Chronic 1 (20%)
Lens, Cataract 1 (100%) 3 (60%) 1 (50%)
Harderian Gland (1) (3) (1)
Inflammation, Chronic Active 1 (100%) 2 (67%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:06:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (80) (81) (80) (80) (30)
Infarct 1 (1%) 1 (1%)
Nephropathy 46 (58%) 41 (51%) 39 (49%) 34 (43%) 6 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:06:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 95 95 95 95 95
Scheduled Sacrifice 44 45 45 45 95
Early Deaths
Moribund Sacrifice 14 16 11 16
Natural Death 5 4 4 6
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 31 30 35 28
Animals Examined Microscopically 95 95 95 95 45
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (79) (79) (79) (79) (30)
Parasite Metazoan 2 (3%) 2 (3%) 3 (4%) 5 (6%) 2 (7%)
Intestine Large, Rectum (80) (79) (78) (79) (30)
Parasite Metazoan 7 (9%) 1 (1%) 8 (10%) 8 (10%) 1 (3%)
Intestine Small, Jejunum (78) (79) (78) (79) (30)
Ulcer 1 (1%) 1 (1%)
Intestine Small, Ileum (78) (79) (78) (79) (30)
Ulcer 1 (1%)
Venule, Parasite Metazoan 1 (1%)
Liver (79) (80) (79) (80) (30)
Angiectasis 1 (1%)
Basophilic Focus 3 (4%) 8 (10%) 6 (8%) 7 (9%)
Clear Cell Focus 1 (1%) 1 (1%) 2 (3%) 1 (1%)
Degeneration, Cystic 7 (9%) 1 (1%) 7 (9%) 5 (6%)
Eosinophilic Focus 9 (11%) 4 (5%) 7 (9%) 6 (8%)
Fatty Change 1 (1%) 1 (1%) 1 (1%)
Hepatodiaphragmatic Nodule 5 (6%) 5 (6%) 5 (6%) 6 (8%) 1 (3%)
Hyperplasia 2 (3%) 2 (3%)
Inflammation, Chronic 1 (1%)
Inflammation, Granulomatous 1 (1%)
Mixed Cell Focus 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Necrosis 1 (1%) 2 (3%) 2 (3%)
Mesentery (6) (8) (5) (9) (2)
Inflammation, Chronic 1 (17%) 1 (13%)
Artery, Inflammation, Chronic 1 (11%)
Fat, Necrosis 4 (67%) 7 (88%) 4 (80%) 6 (67%) 2 (100%)
Pancreas (80) (80) (79) (80) (30)
Inflammation, Chronic 2 (3%) 1 (1%) 2 (3%) 2 (3%) 1 (3%)
Acinus, Atrophy 26 (33%) 28 (35%) 24 (30%) 20 (25%) 4 (13%)
Acinus, Hyperplasia 2 (3%)
Stomach, Forestomach (80) (80) (80) (80) (30)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:06:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Cyst Epithelial Inclusion 1 (1%)
Ulcer 2 (3%) 1 (1%)
Stomach, Glandular (80) (80) (80) (80) (30)
Ulcer 2 (3%) 2 (3%) 3 (4%) 3 (4%)
Tongue (1) (2)
Epithelium, Hyperplasia 1 (100%)
Mucosa, Epithelium, Hyperplasia 2 (100%)
Tooth (1)
Cyst 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (80) (80) (80) (80) (30)
Degeneration 7 (9%) 10 (13%) 8 (10%) 6 (8%) 8 (27%)
Artery, Inflammation, Chronic 1 (1%)
Atrium, Dilatation 1 (1%) 1 (1%)
Atrium, Thrombosis 2 (3%) 1 (1%) 2 (3%)
Intima, Hyperplasia 1 (1%)
Myocardium, Degeneration 48 (60%) 55 (69%) 54 (68%) 50 (63%) 12 (40%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (79) (79) (80) (79) (30)
Hyperplasia 9 (11%) 17 (22%) 10 (13%) 13 (16%) 1 (3%)
Vacuolization Cytoplasmic 10 (33%)
Adrenal Medulla (79) (80) (80) (80) (28)
Hyperplasia 11 (14%) 4 (5%) 6 (8%) 10 (13%) 1 (4%)
Islets, Pancreatic (80) (80) (79) (80) (30)
Hyperplasia 1 (1%) 2 (3%) 3 (4%)
Pituitary Gland (80) (80) (80) (80) (30)
Cyst 1 (1%) 2 (3%) 1 (1%)
Pars Distalis, Cyst 1 (3%)
Pars Distalis, Degeneration, Focal 1 (1%)
Pars Distalis, Hyperplasia 3 (4%) 6 (8%) 10 (13%) 11 (14%) 2 (7%)
Pars Distalis, Inflammation, Chronic 1 (1%)
Pars Distalis, Mineralization 1 (1%)
Pars Intermedia, Hyperplasia 1 (3%)
Thyroid Gland (80) (80) (80) (79) (30)
C-Cell, Hyperplasia 32 (40%) 42 (53%) 48 (60%) 43 (54%) 10 (33%)
Follicle, Dilatation 3 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:06:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (80) (80) (80) (80) (30)
Aspermia 1 (3%)
Hypospermia 1 (1%)
Inflammation, Chronic Active 1 (1%)
Preputial Gland (79) (79) (77) (79) (30)
Hyperplasia 1 (1%) 1 (1%)
Inflammation, Chronic 14 (18%) 23 (29%) 14 (18%) 11 (14%) 6 (20%)
Inflammation, Chronic Active 7 (9%) 5 (6%) 8 (10%) 6 (8%) 9 (30%)
Prostate (80) (80) (80) (80) (30)
Abscess 1 (1%)
Inflammation, Chronic 1 (1%) 2 (3%)
Inflammation, Chronic Active 2 (3%) 4 (5%) 4 (5%) 6 (8%) 6 (20%)
Seminal Vesicle (80) (80) (80) (80) (30)
Inflammation, Chronic 1 (1%) 1 (1%)
Testes (80) (80) (80) (80) (30)
Atrophy 1 (1%)
Hypospermia 1 (1%)
Interstitial Cell, Hyperplasia 1 (1%)
Seminiferous Tubule, Atrophy 2 (3%) 2 (3%) 3 (4%) 1 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (78) (80) (80) (79) (29)
Hyperplasia, Lymphoid 1 (1%)
Lymph Node, Mesenteric (80) (79) (80) (80) (29)
Cyst 1 (1%)
Inflammation, Granulomatous 1 (1%)
Spleen (79) (80) (80) (80) (30)
Congestion 1 (1%)
Fibrosis 3 (4%) 2 (3%) 2 (3%) 6 (8%)
Hematopoietic Cell Proliferation 1 (1%) 2 (3%)
Hyperplasia, Lymphoid 1 (1%)
Infarct 2 (3%)
Capsule, Inflammation, Chronic 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:06:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (75) (75) (75) (74) (29)
Hyperplasia, Cystic 2 (3%)
Skin (80) (79) (80) (80) (29)
Abscess 1 (1%) 1 (1%)
Acanthosis 1 (1%)
Cyst Epithelial Inclusion 1 (1%)
Hyperkeratosis 1 (1%)
Inflammation, Chronic 1 (1%)
Ulcer 1 (1%) 1 (1%) 2 (3%)
Dermis, Mineralization 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (80) (80) (80) (80) (30)
Inflammation, Chronic 1 (1%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (80) (79) (80) (80) (30)
Hydrocephalus 1 (1%)
Infarct 1 (1%)
Hypothalamus, Compression 1 (1%) 1 (1%) 2 (3%) 2 (3%)
Peripheral Nerve (95) (95) (93) (95) (45)
Axon, Degeneration 1 (1%)
Spinal Cord (95) (95) (95) (94) (45)
Cyst 2 (2%) 1 (1%) 1 (1%) 1 (2%)
Nerve, Degeneration 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (80) (80) (80) (80) (30)
Erythrophagocytosis 1 (1%)
Hemorrhage 1 (1%)
Inflammation, Chronic 3 (4%) 4 (5%) 1 (1%) 3 (4%)
Nose (80) (80) (80) (80) (30)
Inflammation, Suppurative 2 (3%) 2 (3%) 4 (5%) 2 (3%)
Nares, Hemorrhage 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:06:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1)
Pinna, Ulcer 1 (100%)
Eye (8) (4) (1) (1)
Inflammation, Chronic 1 (13%)
Phthisis Bulbi 1 (100%)
Lens, Cataract 4 (50%) 3 (75%)
Lens, Cataract, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (80) (80) (80) (80) (30)
Hydronephrosis 1 (1%)
Infarct 1 (1%)
Nephropathy 61 (76%) 61 (76%) 60 (75%) 56 (70%) 15 (50%)
Urinary Bladder (80) (79) (80) (80) (30)
Inflammation, Chronic 1 (1%)
Mucosa, Ulcer 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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