TDMS Study 05100-03 Pathology Tables
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95 Route: DOSED FEED Time: 13:07:00 Facility: Battelle Columbus Laboratory Chemical CAS #: 1330-78-5 Lock Date: 12/30/91 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95 Route: DOSED FEED Time: 13:07:00 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM 23 STOP ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 95 95 95 95 95 Scheduled Sacrifice 44 42 45 44 94 Early Deaths Natural Death 3 3 5 5 Moribund Sacrifice 14 12 15 18 1 Accidently Killed 1 Survivors Natural Death 1 Terminal Sacrifice 34 37 30 26 Missing 1 Animals Examined Microscopically 95 95 95 94 45 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (80) (81) (80) (80) (30) Mesentery (4) (7) (4) (4) (1) Histiocytic Sarcoma 1 (14%) Tooth (1) (1) Gingiva, Squamous Cell Carcinoma 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (80) (81) (80) (80) (30) Histiocytic Sarcoma 1 (1%) Rhabdomyoma 1 (1%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (80) (81) (80) (80) (29) Adenoma 1 (1%) 1 (1%) 1 (1%) Adrenal Medulla (80) (81) (80) (80) (29) Pheochromocytoma Malignant 1 (1%) Pheochromocytoma Benign 1 (1%) 2 (2%) 2 (3%) Bilateral, Pheochromocytoma Benign 1 (1%) Islets, Pancreatic (80) (81) (80) (80) (30) Adenoma 1 (1%) Carcinoma 1 (1%) Pituitary Gland (80) (81) (80) (80) (30) Pars Distalis, Adenoma 30 (38%) 26 (32%) 27 (34%) 24 (30%) 3 (10%) Thyroid Gland (80) (81) (80) (80) (30) Page 2 NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95 Route: DOSED FEED Time: 13:07:00 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM 23 STOP ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Bilateral, C-Cell, Adenoma 1 (1%) C-Cell, Adenocarcinoma 1 (1%) C-Cell, Adenoma 9 (11%) 8 (10%) 3 (4%) 11 (14%) Follicle, Adenoma 1 (1%) 2 (3%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (80) (81) (79) (79) (30) Adenoma 1 (1%) 2 (2%) 3 (4%) 3 (4%) Carcinoma 1 (1%) 1 (1%) Bilateral, Adenoma 2 (2%) 1 (1%) Ovary (80) (81) (80) (80) (30) Adenoma 1 (1%) Granulosa Cell Tumor Benign 1 (1%) 1 (1%) Granulosa-Theca Tumor Malignant 1 (1%) Granulosa-Theca Tumor Benign 1 (1%) Uterus (80) (81) (80) (80) (30) Adenocarcinoma 1 (1%) Leiomyosarcoma 1 (1%) Polyp Stromal 7 (9%) 2 (2%) 8 (10%) 9 (11%) 1 (3%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (2) (2) (2) (2) (1) Lymph Node, Mandibular (80) (81) (78) (80) (30) Squamous Cell Carcinoma, Metastatic, Skin 1 (1%) Lymph Node, Mesenteric (79) (80) (80) (78) (30) Spleen (79) (81) (80) (80) (30) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (77) (81) (79) (79) (30) Adenocarcinoma 1 (1%) Adenoma 2 (3%) 1 (1%) 1 (1%) Adenoma, Multiple 1 (1%) Fibroadenoma 13 (17%) 13 (16%) 18 (23%) 14 (18%) Fibroadenoma, Multiple 2 (3%) 3 (4%) 3 (4%) 1 (1%) Skin (80) (81) (80) (80) (30) Fibrosarcoma 2 (3%) Page 3 NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95 Route: DOSED FEED Time: 13:07:00 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM 23 STOP ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont Squamous Cell Carcinoma 1 (1%) 1 (1%) Trichoepithelioma 1 (1%) Subcutaneous Tissue, Fibroma 1 (1%) Subcutaneous Tissue, Fibrous Histiocytoma 1 (1%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (80) (81) (80) (80) (29) Osteosarcoma 1 (1%) Skeletal Muscle (1) Hemangioma 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (80) (81) (80) (80) (30) Astrocytoma Malignant 1 (1%) Spinal Cord (95) (93) (95) (94) (45) Hemangiosarcoma 1 (1%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (80) (81) (80) (80) (30) Alveolar/Bronchiolar Adenoma 1 (1%) 1 (1%) Alveolar/Bronchiolar Carcinoma 1 (1%) 1 (1%) Histiocytic Sarcoma 1 (1%) Pheochromocytoma Malignant, Metastatic, Adrenal Medulla 1 (1%) Nose (80) (81) (80) (80) (30) Chondrosarcoma 1 (1%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Ear (1) Pinna, Fibrosarcoma 1 (100%) Zymbal's Gland (2) Carcinoma 2 (100%) ____________________________________________________________________________________________________________________________________ Page 4 NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95 Route: DOSED FEED Time: 13:07:00 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM 23 STOP ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (80) (81) (80) (80) (30) Urinary Bladder (80) (81) (80) (80) (30) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(95) *(95) *(95) *(94) *(45) Histiocytic Sarcoma 1 (1%) Leukemia Mononuclear 8 (8%) 8 (8%) 13 (14%) 15 (16%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95 Route: DOSED FEED Time: 13:07:00 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM 23 STOP ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 50 44 48 48 4 Total Primary Neoplasms 85 79 89 89 4 Total Animals with Benign Neoplasms 47 36 42 44 4 Total Benign Neoplasms 71 63 71 68 4 Total Animals with Malignant Neoplasms 14 16 18 20 Total Malignant Neoplasms 14 16 18 21 Total Animals with Metastatic Neoplasms 2 Total Metastatic Neoplasm 2 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 6 NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95 Route: DOSED FEED Time: 13:07:00 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM 23 STOP ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 95 95 95 95 95 Scheduled Sacrifice 44 45 45 45 95 Early Deaths Moribund Sacrifice 14 16 11 16 Natural Death 5 4 4 6 Survivors Moribund Sacrifice 1 Terminal Sacrifice 31 30 35 28 Animals Examined Microscopically 95 95 95 95 45 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Small, Jejunum (78) (79) (78) (79) (30) Mast Cell Tumor Benign 1 (1%) 1 (1%) Liver (79) (80) (79) (80) (30) Hepatocellular Adenoma 1 (1%) 1 (1%) 1 (1%) Mesentery (6) (8) (5) (9) (2) Liposarcoma 1 (11%) Schwannoma Malignant 1 (17%) Pancreas (80) (80) (79) (80) (30) Stomach, Forestomach (80) (80) (80) (80) (30) Squamous Cell Papilloma 1 (1%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (80) (80) (80) (80) (30) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (79) (79) (80) (79) (30) Adenoma 1 (1%) 2 (3%) 2 (3%) 3 (4%) Adrenal Medulla (79) (80) (80) (80) (28) Ganglioneuroma 1 (1%) Pheochromocytoma Malignant 1 (1%) 1 (1%) Pheochromocytoma Benign 5 (6%) 7 (9%) 5 (6%) 4 (5%) Bilateral, Pheochromocytoma Complex 1 (1%) Bilateral, Pheochromocytoma Benign 4 (5%) 1 (1%) Islets, Pancreatic (80) (80) (79) (80) (30) Adenoma 3 (4%) 3 (4%) 1 (1%) 1 (3%) Carcinoma 1 (1%) Page 7 NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95 Route: DOSED FEED Time: 13:07:00 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM 23 STOP ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Pituitary Gland (80) (80) (80) (80) (30) Pars Distalis, Adenoma 8 (10%) 11 (14%) 16 (20%) 4 (5%) Pars Distalis, Adenoma, Multiple 1 (1%) 1 (1%) 1 (1%) Pars Intermedia, Adenoma 1 (1%) Thyroid Gland (80) (80) (80) (79) (30) Bilateral, C-Cell, Adenoma 1 (1%) 2 (3%) 2 (3%) C-Cell, Adenoma 11 (14%) 7 (9%) 6 (8%) 6 (8%) C-Cell, Carcinoma 1 (1%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (80) (80) (80) (80) (30) Preputial Gland (79) (79) (77) (79) (30) Adenoma 4 (5%) 3 (4%) 3 (4%) 3 (4%) Carcinoma 1 (1%) Seminal Vesicle (80) (80) (80) (80) (30) Testes (80) (80) (80) (80) (30) Adenoma 1 (1%) Bilateral, Interstitial Cell, Adenoma 48 (60%) 48 (60%) 47 (59%) 47 (59%) 9 (30%) Interstitial Cell, Adenoma 10 (13%) 6 (8%) 8 (10%) 11 (14%) 1 (3%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (4) (6) (5) (5) Lymph Node, Mandibular (78) (80) (80) (79) (29) Lymph Node, Mesenteric (80) (79) (80) (80) (29) Spleen (79) (80) (80) (80) (30) Sarcoma 1 (1%) 1 (1%) Thymus (79) (77) (77) (79) (30) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (75) (75) (75) (74) (29) Fibroadenoma 3 (4%) 2 (3%) 2 (3%) Skin (80) (79) (80) (80) (29) Basal Cell Adenoma 1 (1%) Basosquamous Tumor Benign 1 (1%) Fibroma 1 (1%) Keratoacanthoma 2 (3%) Page 8 NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95 Route: DOSED FEED Time: 13:07:00 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM 23 STOP ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont Squamous Cell Carcinoma 1 (1%) Squamous Cell Papilloma 1 (1%) Subcutaneous Tissue, Fibroma 1 (1%) Subcutaneous Tissue, Fibrosarcoma 1 (1%) 1 (1%) Subcutaneous Tissue, Fibrous Histiocytoma 1 (1%) Subcutaneous Tissue, Lipoma 1 (1%) Subcutaneous Tissue, Sarcoma 1 (1%) Subcutaneous Tissue, Schwannoma Malignant 1 (1%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Skeletal Muscle (1) (2) (1) Sarcoma 1 (50%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (80) (79) (80) (80) (30) Astrocytoma Benign 1 (1%) Granular Cell Tumor Benign 1 (1%) Oligodendroglioma Benign 1 (1%) Peripheral Nerve (95) (95) (93) (95) (45) Spinal Cord (95) (95) (95) (94) (45) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (80) (80) (80) (80) (30) Alveolar/Bronchiolar Carcinoma 1 (1%) Nose (80) (80) (80) (80) (30) Squamous Cell Carcinoma 1 (1%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Ear (1) (1) Pinna, Fibrosarcoma 1 (100%) Zymbal's Gland (1) (1) (1) (1) Carcinoma 1 (100%) 1 (100%) 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ Page 9 NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95 Route: DOSED FEED Time: 13:07:00 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM 23 STOP ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (80) (80) (80) (80) (30) Urinary Bladder (80) (79) (80) (80) (30) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(95) *(95) *(95) *(95) *(45) Leukemia Mononuclear 20 (21%) 18 (19%) 16 (17%) 20 (21%) 2 (4%) Mesothelioma Benign 1 (1%) Mesothelioma Malignant 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 10 NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95 Route: DOSED FEED Time: 13:07:00 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM 23 STOP ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 60 59 58 59 11 Total Primary Neoplasms 133 118 118 115 14 Total Animals with Benign Neoplasms 59 58 57 59 10 Total Benign Neoplasms 102 94 99 89 12 Total Animals with Malignant Neoplasms 29 24 19 24 2 Total Malignant Neoplasms 31 24 19 26 2 Total Animals with Metastatic Neoplasms 1 Total Metastatic Neoplasm 2 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 11 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------