TDMS Study 05100-03 Pathology Tables
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:07:00
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1330-78-5
Lock Date: 12/30/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:07:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 95 95 95 95 95
Scheduled Sacrifice 44 42 45 44 94
Early Deaths
Natural Death 3 3 5 5
Moribund Sacrifice 14 12 15 18 1
Accidently Killed 1
Survivors
Natural Death 1
Terminal Sacrifice 34 37 30 26
Missing 1
Animals Examined Microscopically 95 95 95 94 45
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (80) (81) (80) (80) (30)
Mesentery (4) (7) (4) (4) (1)
Histiocytic Sarcoma 1 (14%)
Tooth (1) (1)
Gingiva, Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (80) (81) (80) (80) (30)
Histiocytic Sarcoma 1 (1%)
Rhabdomyoma 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (80) (81) (80) (80) (29)
Adenoma 1 (1%) 1 (1%) 1 (1%)
Adrenal Medulla (80) (81) (80) (80) (29)
Pheochromocytoma Malignant 1 (1%)
Pheochromocytoma Benign 1 (1%) 2 (2%) 2 (3%)
Bilateral, Pheochromocytoma Benign 1 (1%)
Islets, Pancreatic (80) (81) (80) (80) (30)
Adenoma 1 (1%)
Carcinoma 1 (1%)
Pituitary Gland (80) (81) (80) (80) (30)
Pars Distalis, Adenoma 30 (38%) 26 (32%) 27 (34%) 24 (30%) 3 (10%)
Thyroid Gland (80) (81) (80) (80) (30)
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NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:07:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Bilateral, C-Cell, Adenoma 1 (1%)
C-Cell, Adenocarcinoma 1 (1%)
C-Cell, Adenoma 9 (11%) 8 (10%) 3 (4%) 11 (14%)
Follicle, Adenoma 1 (1%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (80) (81) (79) (79) (30)
Adenoma 1 (1%) 2 (2%) 3 (4%) 3 (4%)
Carcinoma 1 (1%) 1 (1%)
Bilateral, Adenoma 2 (2%) 1 (1%)
Ovary (80) (81) (80) (80) (30)
Adenoma 1 (1%)
Granulosa Cell Tumor Benign 1 (1%) 1 (1%)
Granulosa-Theca Tumor Malignant 1 (1%)
Granulosa-Theca Tumor Benign 1 (1%)
Uterus (80) (81) (80) (80) (30)
Adenocarcinoma 1 (1%)
Leiomyosarcoma 1 (1%)
Polyp Stromal 7 (9%) 2 (2%) 8 (10%) 9 (11%) 1 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (2) (2) (2) (2) (1)
Lymph Node, Mandibular (80) (81) (78) (80) (30)
Squamous Cell Carcinoma, Metastatic, Skin 1 (1%)
Lymph Node, Mesenteric (79) (80) (80) (78) (30)
Spleen (79) (81) (80) (80) (30)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (77) (81) (79) (79) (30)
Adenocarcinoma 1 (1%)
Adenoma 2 (3%) 1 (1%) 1 (1%)
Adenoma, Multiple 1 (1%)
Fibroadenoma 13 (17%) 13 (16%) 18 (23%) 14 (18%)
Fibroadenoma, Multiple 2 (3%) 3 (4%) 3 (4%) 1 (1%)
Skin (80) (81) (80) (80) (30)
Fibrosarcoma 2 (3%)
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NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:07:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Squamous Cell Carcinoma 1 (1%) 1 (1%)
Trichoepithelioma 1 (1%)
Subcutaneous Tissue, Fibroma 1 (1%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (80) (81) (80) (80) (29)
Osteosarcoma 1 (1%)
Skeletal Muscle (1)
Hemangioma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (80) (81) (80) (80) (30)
Astrocytoma Malignant 1 (1%)
Spinal Cord (95) (93) (95) (94) (45)
Hemangiosarcoma 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (80) (81) (80) (80) (30)
Alveolar/Bronchiolar Adenoma 1 (1%) 1 (1%)
Alveolar/Bronchiolar Carcinoma 1 (1%) 1 (1%)
Histiocytic Sarcoma 1 (1%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (1%)
Nose (80) (81) (80) (80) (30)
Chondrosarcoma 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Pinna, Fibrosarcoma 1 (100%)
Zymbal's Gland (2)
Carcinoma 2 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:07:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (80) (81) (80) (80) (30)
Urinary Bladder (80) (81) (80) (80) (30)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(95) *(95) *(95) *(94) *(45)
Histiocytic Sarcoma 1 (1%)
Leukemia Mononuclear 8 (8%) 8 (8%) 13 (14%) 15 (16%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:07:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 44 48 48 4
Total Primary Neoplasms 85 79 89 89 4
Total Animals with Benign Neoplasms 47 36 42 44 4
Total Benign Neoplasms 71 63 71 68 4
Total Animals with Malignant Neoplasms 14 16 18 20
Total Malignant Neoplasms 14 16 18 21
Total Animals with Metastatic Neoplasms 2
Total Metastatic Neoplasm 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:07:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 95 95 95 95 95
Scheduled Sacrifice 44 45 45 45 95
Early Deaths
Moribund Sacrifice 14 16 11 16
Natural Death 5 4 4 6
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 31 30 35 28
Animals Examined Microscopically 95 95 95 95 45
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (78) (79) (78) (79) (30)
Mast Cell Tumor Benign 1 (1%) 1 (1%)
Liver (79) (80) (79) (80) (30)
Hepatocellular Adenoma 1 (1%) 1 (1%) 1 (1%)
Mesentery (6) (8) (5) (9) (2)
Liposarcoma 1 (11%)
Schwannoma Malignant 1 (17%)
Pancreas (80) (80) (79) (80) (30)
Stomach, Forestomach (80) (80) (80) (80) (30)
Squamous Cell Papilloma 1 (1%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (80) (80) (80) (80) (30)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (79) (79) (80) (79) (30)
Adenoma 1 (1%) 2 (3%) 2 (3%) 3 (4%)
Adrenal Medulla (79) (80) (80) (80) (28)
Ganglioneuroma 1 (1%)
Pheochromocytoma Malignant 1 (1%) 1 (1%)
Pheochromocytoma Benign 5 (6%) 7 (9%) 5 (6%) 4 (5%)
Bilateral, Pheochromocytoma Complex 1 (1%)
Bilateral, Pheochromocytoma Benign 4 (5%) 1 (1%)
Islets, Pancreatic (80) (80) (79) (80) (30)
Adenoma 3 (4%) 3 (4%) 1 (1%) 1 (3%)
Carcinoma 1 (1%)
Page 7
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:07:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pituitary Gland (80) (80) (80) (80) (30)
Pars Distalis, Adenoma 8 (10%) 11 (14%) 16 (20%) 4 (5%)
Pars Distalis, Adenoma, Multiple 1 (1%) 1 (1%) 1 (1%)
Pars Intermedia, Adenoma 1 (1%)
Thyroid Gland (80) (80) (80) (79) (30)
Bilateral, C-Cell, Adenoma 1 (1%) 2 (3%) 2 (3%)
C-Cell, Adenoma 11 (14%) 7 (9%) 6 (8%) 6 (8%)
C-Cell, Carcinoma 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (80) (80) (80) (80) (30)
Preputial Gland (79) (79) (77) (79) (30)
Adenoma 4 (5%) 3 (4%) 3 (4%) 3 (4%)
Carcinoma 1 (1%)
Seminal Vesicle (80) (80) (80) (80) (30)
Testes (80) (80) (80) (80) (30)
Adenoma 1 (1%)
Bilateral, Interstitial Cell, Adenoma 48 (60%) 48 (60%) 47 (59%) 47 (59%) 9 (30%)
Interstitial Cell, Adenoma 10 (13%) 6 (8%) 8 (10%) 11 (14%) 1 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (4) (6) (5) (5)
Lymph Node, Mandibular (78) (80) (80) (79) (29)
Lymph Node, Mesenteric (80) (79) (80) (80) (29)
Spleen (79) (80) (80) (80) (30)
Sarcoma 1 (1%) 1 (1%)
Thymus (79) (77) (77) (79) (30)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (75) (75) (75) (74) (29)
Fibroadenoma 3 (4%) 2 (3%) 2 (3%)
Skin (80) (79) (80) (80) (29)
Basal Cell Adenoma 1 (1%)
Basosquamous Tumor Benign 1 (1%)
Fibroma 1 (1%)
Keratoacanthoma 2 (3%)
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NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:07:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Squamous Cell Carcinoma 1 (1%)
Squamous Cell Papilloma 1 (1%)
Subcutaneous Tissue, Fibroma 1 (1%)
Subcutaneous Tissue, Fibrosarcoma 1 (1%) 1 (1%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (1%)
Subcutaneous Tissue, Lipoma 1 (1%)
Subcutaneous Tissue, Sarcoma 1 (1%)
Subcutaneous Tissue, Schwannoma Malignant 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (2) (1)
Sarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (80) (79) (80) (80) (30)
Astrocytoma Benign 1 (1%)
Granular Cell Tumor Benign 1 (1%)
Oligodendroglioma Benign 1 (1%)
Peripheral Nerve (95) (95) (93) (95) (45)
Spinal Cord (95) (95) (95) (94) (45)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (80) (80) (80) (80) (30)
Alveolar/Bronchiolar Carcinoma 1 (1%)
Nose (80) (80) (80) (80) (30)
Squamous Cell Carcinoma 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1)
Pinna, Fibrosarcoma 1 (100%)
Zymbal's Gland (1) (1) (1) (1)
Carcinoma 1 (100%) 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:07:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (80) (80) (80) (80) (30)
Urinary Bladder (80) (79) (80) (80) (30)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(95) *(95) *(95) *(95) *(45)
Leukemia Mononuclear 20 (21%) 18 (19%) 16 (17%) 20 (21%) 2 (4%)
Mesothelioma Benign 1 (1%)
Mesothelioma Malignant 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05100-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 11/09/95
Route: DOSED FEED Time: 13:07:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM
23 STOP
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 60 59 58 59 11
Total Primary Neoplasms 133 118 118 115 14
Total Animals with Benign Neoplasms 59 58 57 59 10
Total Benign Neoplasms 102 94 99 89 12
Total Animals with Malignant Neoplasms 29 24 19 24 2
Total Malignant Neoplasms 31 24 19 26 2
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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