TDMS Study 05100-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus TRICRESYL PHOSPHATE DATE: 11/10/95
EXPERIMENT: 05100 TEST: 03 TIME: 14:27:13
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45050 ROUTE: DOSED FEED NTP C#: 10277D
PATHOLOGIST: M. RYAN CAS: 1330-78-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus TRICRESYL PHOSPHATE DATE: 11/10/95
EXPERIMENT: 05100 TEST: 03 TIME: 14:27:13
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45050 ROUTE: DOSED FEED NTP C#: 10277D
PATHOLOGIST: M. RYAN CAS: 1330-78-5
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus TRICRESYL PHOSPHATE DATE: 11/10/95
EXPERIMENT: 05100 TEST: 03 TIME: 14:27:13
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45050 ROUTE: DOSED FEED NTP C#: 10277D
PATHOLOGIST: M. RYAN CAS: 1330-78-5
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF TRICRESYL PHOSPHATE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Skin Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal
Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma
Testes Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/79 (1%) 2/79 (3%) 2/80 (3%) 3/79 (4%) 0/30 (0%) |
|ADJUSTED (b) | 3.2% 6.1% 5.3% 11.1% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/31 (3%) 1/29 (3%) 1/35 (3%) 3/27 (11%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 690 701 729 (T) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.272 P=0.478 P=0.534 P=0.256 (e) |
|INCIDENTAL TUMOR | P=0.275 P=0.461 P=0.440 P=0.256 (e) |
|LOGISTIC REGRESSION | P=0.287 P=0.477 P=0.514 P=0.256 (e) |
|COCHRAN-ARMITAGE | P=0.605N |
|FISHER EXACT | P=0.500 P=0.505 P=0.310 P=0.725N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/79 (6%) 7/80 (9%) 9/80 (11%) 5/80 (6%) 0/28 (0%) |
|ADJUSTED (b) | 16.1% 20.6% 24.3% 16.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/31 (16%) 5/30 (17%) 7/35 (20%) 4/28 (14%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 586 722 656 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.584 P=0.357 P=0.263 P=0.568 (e) |
|INCIDENTAL TUMOR | P=0.605 P=0.379 P=0.187 P=0.566 (e) |
|LOGISTIC REGRESSION | P=0.601N P=0.357 P=0.247 P=0.580 (e) |
|COCHRAN-ARMITAGE | P=0.140N |
|FISHER EXACT | P=0.392 P=0.208 P=0.619N P=0.212N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 7/79 (9%) 8/80 (10%) 9/80 (11%) 5/80 (6%) 0/28 (0%) |
|ADJUSTED (b) | 22.6% 22.7% 24.3% 16.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 7/31 (23%) 5/30 (17%) 7/35 (20%) 4/28 (14%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 586 722 656 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.413N P=0.472 P=0.493 P=0.450N (e) |
|INCIDENTAL TUMOR | P=0.394N P=0.486 P=0.400 P=0.451N (e) |
|LOGISTIC REGRESSION | P=0.362N P=0.476 P=0.481 P=0.441N (e) |
|COCHRAN-ARMITAGE | P=0.062N |
|FISHER EXACT | P=0.510 P=0.407 P=0.374N P=0.111N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 4/79 (5%) 3/79 (4%) 3/77 (4%) 3/79 (4%) 0/30 (0%) |
|ADJUSTED (b) | 11.6% 9.1% 8.6% 8.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/9 (11%) 0/10 (0%) |
|TERMINAL (d) | 3/31 (10%) 2/29 (7%) 3/35 (9%) 1/28 (4%) 0/0 |
|FIRST INCIDENCE (DAYS) | 558 614 729 (T) 455 (I) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.455N P=0.529N P=0.448N P=0.550N (e) |
|INCIDENTAL TUMOR | P=0.398N P=0.440N P=0.426N P=0.481N (e) |
|LOGISTIC REGRESSION | P=0.431N P=0.521N P=0.499N P=0.503N P=0.845N |
|COCHRAN-ARMITAGE | P=0.197N |
|FISHER EXACT | P=0.500N P=0.514N P=0.500N P=0.270N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 4/79 (5%) 4/79 (5%) 3/77 (4%) 3/79 (4%) 0/30 (0%) |
|ADJUSTED (b) | 11.6% 12.4% 8.6% 8.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/9 (11%) 0/10 (0%) |
|TERMINAL (d) | 3/31 (10%) 3/29 (10%) 3/35 (9%) 1/28 (4%) 0/0 |
|FIRST INCIDENCE (DAYS) | 558 614 729 (T) 455 (I) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.408N P=0.612 P=0.448N P=0.550N (e) |
|INCIDENTAL TUMOR | P=0.354N P=0.597N P=0.426N P=0.481N (e) |
|LOGISTIC REGRESSION | P=0.386N P=0.621 P=0.499N P=0.503N P=0.845N |
|COCHRAN-ARMITAGE | P=0.164N |
|FISHER EXACT | P=0.640N P=0.514N P=0.500N P=0.270N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/80 (4%) 0/80 (0%) 3/79 (4%) 1/80 (1%) 1/30 (3%) |
|ADJUSTED (b) | 7.5% 0.0% 8.3% 3.6% 10.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 1/32 (3%) 0/30 (0%) 2/35 (6%) 1/28 (4%) 0/0 |
|FIRST INCIDENCE (DAYS) | 455 (I) --- 722 729 (T) 455 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.509 P=0.133N P=0.626N P=0.349N P=0.766 |
|INCIDENTAL TUMOR | P=0.512 P=0.140N P=0.565 P=0.340N P=0.766 |
|LOGISTIC REGRESSION | P=0.442 P=0.125N P=0.657 P=0.312N P=0.572 |
|COCHRAN-ARMITAGE | P=0.607N |
|FISHER EXACT | P=0.123N P=0.653 P=0.310N P=0.701N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/80 (4%) 1/80 (1%) 3/79 (4%) 1/80 (1%) 1/30 (3%) |
|ADJUSTED (b) | 7.5% 3.3% 8.3% 3.6% 10.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 1/32 (3%) 1/30 (3%) 2/35 (6%) 1/28 (4%) 0/0 |
|FIRST INCIDENCE (DAYS) | 455 (I) 729 (T) 722 729 (T) 455 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.560 P=0.328N P=0.626N P=0.349N P=0.766 |
|INCIDENTAL TUMOR | P=0.561 P=0.337N P=0.565 P=0.340N P=0.766 |
|LOGISTIC REGRESSION | P=0.500 P=0.315N P=0.657 P=0.312N P=0.572 |
|COCHRAN-ARMITAGE | P=0.525N |
|FISHER EXACT | P=0.310N P=0.653 P=0.310N P=0.701N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/80 (1%) 0/80 (0%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 3.1% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/32 (3%) 0/30 (0%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.584N P=0.513N P=0.482N P=0.527N (e) |
|INCIDENTAL TUMOR | P=0.584N P=0.513N P=0.482N P=0.527N (e) |
|LOGISTIC REGRESSION | P=0.584N P=0.513N P=0.482N P=0.527N (e) |
|COCHRAN-ARMITAGE | P=0.449N |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N P=0.727N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 0/80 (0%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/30 (0%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 0/80 (0%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/30 (0%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 3/80 (4%) 2/80 (3%) 2/80 (3%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 7.5% 5.7% 5.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 1/30 (3%) 2/35 (6%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 498 729 (T) 614 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.409 P=0.119 P=0.258 P=0.232 (e) |
|INCIDENTAL TUMOR | P=0.473 P=0.152 P=0.258 P=0.323 (e) |
|LOGISTIC REGRESSION | P=0.532 P=0.119 P=0.258 P=0.234 (e) |
|COCHRAN-ARMITAGE | P=0.567N |
|FISHER EXACT | P=0.123 P=0.248 P=0.248 (e) |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 3/80 (4%) 2/80 (3%) 2/80 (3%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 7.5% 5.7% 5.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 1/30 (3%) 2/35 (6%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 498 729 (T) 614 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.409 P=0.119 P=0.258 P=0.232 (e) |
|INCIDENTAL TUMOR | P=0.473 P=0.152 P=0.258 P=0.323 (e) |
|LOGISTIC REGRESSION | P=0.532 P=0.119 P=0.258 P=0.234 (e) |
|COCHRAN-ARMITAGE | P=0.567N |
|FISHER EXACT | P=0.123 P=0.248 P=0.248 (e) |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 3/80 (4%) 2/80 (3%) 2/80 (3%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 7.5% 5.7% 5.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 1/30 (3%) 2/35 (6%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 498 729 (T) 614 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.409 P=0.119 P=0.258 P=0.232 (e) |
|INCIDENTAL TUMOR | P=0.473 P=0.152 P=0.258 P=0.323 (e) |
|LOGISTIC REGRESSION | P=0.532 P=0.119 P=0.258 P=0.234 (e) |
|COCHRAN-ARMITAGE | P=0.567N |
|FISHER EXACT | P=0.123 P=0.248 P=0.248 (e) |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 9/80 (11%) 12/80 (15%) 16/80 (20%) 5/80 (6%) 0/30 (0%) |
|ADJUSTED (b) | 24.1% 38.1% 36.9% 14.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 1/10 (10%) 0/10 (0%) 2/10 (20%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 6/32 (19%) 11/30 (37%) 10/35 (29%) 3/28 (11%) 0/0 |
|FIRST INCIDENCE (DAYS) | 455 (I) 614 454 455 (I) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.131N P=0.256 P=0.123 P=0.260N P=0.500N |
|INCIDENTAL TUMOR | P=0.126N P=0.270 P=0.089 P=0.276N P=0.500N |
|LOGISTIC REGRESSION | P=0.112N P=0.267 P=0.085 P=0.207N P=0.591N |
|COCHRAN-ARMITAGE | P=0.014N* |
|FISHER EXACT | P=0.320 P=0.095 P=0.201N P=0.050N* |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Adenoma or Basosquamous Tumor Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/80 (3%) 0/80 (0%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 6.3% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/32 (6%) 0/30 (0%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.246N P=0.252N P=0.219N P=0.268N (e) |
|INCIDENTAL TUMOR | P=0.246N P=0.252N P=0.219N P=0.268N (e) |
|LOGISTIC REGRESSION | P=0.246N P=0.252N P=0.219N P=0.268N (e) |
|COCHRAN-ARMITAGE | P=0.209N |
|FISHER EXACT | P=0.248N P=0.248N P=0.248N P=0.527N |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Adenoma, Basosquamous Tumor Benign, or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/80 (3%) 0/80 (0%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 6.3% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/32 (6%) 0/30 (0%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.246N P=0.252N P=0.219N P=0.268N (e) |
|INCIDENTAL TUMOR | P=0.246N P=0.252N P=0.219N P=0.268N (e) |
|LOGISTIC REGRESSION | P=0.246N P=0.252N P=0.219N P=0.268N (e) |
|COCHRAN-ARMITAGE | P=0.209N |
|FISHER EXACT | P=0.248N P=0.248N P=0.248N P=0.527N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, |
| malignant or NOS), or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/80 (3%) 0/80 (0%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 6.3% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/32 (6%) 0/30 (0%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.246N P=0.252N P=0.219N P=0.268N (e) |
|INCIDENTAL TUMOR | P=0.246N P=0.252N P=0.219N P=0.268N (e) |
|LOGISTIC REGRESSION | P=0.246N P=0.252N P=0.219N P=0.268N (e) |
|COCHRAN-ARMITAGE | P=0.209N |
|FISHER EXACT | P=0.248N P=0.248N P=0.248N P=0.527N |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 4/80 (5%) 1/80 (1%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 11.8% 1.7% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/32 (9%) 0/30 (0%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 701 455 (I) --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.046N* P=0.202N P=0.055N P=0.083N (e) |
|INCIDENTAL TUMOR | P=0.049N* P=0.207N P=0.077N P=0.081N (e) |
|LOGISTIC REGRESSION | P=0.044N* P=0.189N P=0.059N P=0.076N (e) |
|COCHRAN-ARMITAGE | P=0.046N* |
|FISHER EXACT | P=0.184N P=0.060N P=0.060N P=0.274N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 3/80 (4%) 1/80 (1%) 1/80 (1%) 1/80 (1%) 0/30 (0%) |
|ADJUSTED (b) | 8.8% 3.0% 2.4% 3.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/32 (6%) 0/30 (0%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 701 701 624 711 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.365N P=0.339N P=0.292N P=0.356N (e) |
|INCIDENTAL TUMOR | P=0.329N P=0.354N P=0.336N P=0.347N (e) |
|LOGISTIC REGRESSION | P=0.323N P=0.326N P=0.306N P=0.336N (e) |
|COCHRAN-ARMITAGE | P=0.194N |
|FISHER EXACT | P=0.310N P=0.310N P=0.310N P=0.381N |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/80 (1%) 0/80 (0%) 0/80 (0%) 1/80 (1%) 0/30 (0%) |
|ADJUSTED (b) | 3.1% 0.0% 0.0% 3.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/32 (3%) 0/30 (0%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- 711 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.755 P=0.513N P=0.482N P=0.731 (e) |
|INCIDENTAL TUMOR | P=0.740 P=0.513N P=0.482N P=0.735 (e) |
|LOGISTIC REGRESSION | P=0.757 P=0.513N P=0.482N P=0.742 (e) |
|COCHRAN-ARMITAGE | P=0.674N |
|FISHER EXACT | P=0.500N P=0.500N P=0.752N P=0.727N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/80 (3%) 0/80 (0%) 1/80 (1%) 1/80 (1%) 0/30 (0%) |
|ADJUSTED (b) | 5.7% 0.0% 2.4% 3.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/32 (3%) 0/30 (0%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 701 --- 624 711 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.656N P=0.260N P=0.489N P=0.546N (e) |
|INCIDENTAL TUMOR | P=0.595N P=0.269N P=0.552N P=0.538N (e) |
|LOGISTIC REGRESSION | P=0.593N P=0.251N P=0.502N P=0.526N (e) |
|COCHRAN-ARMITAGE | P=0.399N |
|FISHER EXACT | P=0.248N P=0.500N P=0.500N P=0.527N |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/80 (3%) 0/80 (0%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 5.7% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/32 (3%) 0/30 (0%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 701 --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.248N P=0.260N P=0.224N P=0.271N (e) |
|INCIDENTAL TUMOR | P=0.260N P=0.269N P=0.312N P=0.265N (e) |
|LOGISTIC REGRESSION | P=0.241N P=0.251N P=0.236N P=0.254N (e) |
|COCHRAN-ARMITAGE | P=0.209N |
|FISHER EXACT | P=0.248N P=0.248N P=0.248N P=0.527N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 3/80 (4%) 1/80 (1%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 8.8% 1.7% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/32 (6%) 0/30 (0%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 701 455 (I) --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.089N P=0.329N P=0.110N P=0.148N (e) |
|INCIDENTAL TUMOR | P=0.092N P=0.337N P=0.154N P=0.145N (e) |
|LOGISTIC REGRESSION | P=0.088N P=0.314N P=0.117N P=0.137N (e) |
|COCHRAN-ARMITAGE | P=0.085N |
|FISHER EXACT | P=0.310N P=0.123N P=0.123N P=0.381N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/80 (3%) 1/80 (1%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 5.7% 1.7% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/32 (3%) 0/30 (0%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 701 455 (I) --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.165N P=0.521N P=0.224N P=0.271N (e) |
|INCIDENTAL TUMOR | P=0.171N P=0.530N P=0.312N P=0.265N (e) |
|LOGISTIC REGRESSION | P=0.174N P=0.506N P=0.236N P=0.254N (e) |
|COCHRAN-ARMITAGE | P=0.160N |
|FISHER EXACT | P=0.500N P=0.248N P=0.248N P=0.527N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 58/80 (73%) 55/80 (69%) 55/80 (69%) 58/80 (73%) 10/30 (33%) |
|ADJUSTED (b) | 100.0% 94.8% 100.0% 100.0% 100.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 10/10 (100%) 10/10 (100%) 9/10 (90%) 9/10 (90%) 10/10 (100%) |
|TERMINAL (d) | 32/32 (100%) 27/30 (90%) 35/35 (100%) 28/28 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 455 (I) 455 (I) 455 (I) 455 (I) 455 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.217 P=0.561N P=0.168N P=0.240 (e) |
|INCIDENTAL TUMOR | P=0.443 P=0.362N P=0.437N P=0.705 (e) |
|LOGISTIC REGRESSION | P=0.188 P=0.326N P=0.352N P=0.640N P=0.326 |
|COCHRAN-ARMITAGE | P=0.001N** |
|FISHER EXACT | P=0.364N P=0.364N P=0.570N P<0.001N** |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 12/80 (15%) 9/80 (11%) 6/80 (8%) 8/79 (10%) 0/30 (0%) |
|ADJUSTED (b) | 32.8% 23.0% 17.1% 23.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 8/32 (25%) 4/30 (13%) 6/35 (17%) 5/28 (18%) 0/0 |
|FIRST INCIDENCE (DAYS) | 647 586 729 (T) 589 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.276N P=0.374N P=0.073N P=0.329N (e) |
|INCIDENTAL TUMOR | P=0.195N P=0.293N P=0.135N P=0.252N (e) |
|LOGISTIC REGRESSION | P=0.176N P=0.269N P=0.088N P=0.271N P=0.957N |
|COCHRAN-ARMITAGE | P=0.025N* |
|FISHER EXACT | P=0.320N P=0.105N P=0.246N P=0.017N* |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 12/80 (15%) 10/80 (13%) 6/80 (8%) 8/79 (10%) 0/30 (0%) |
|ADJUSTED (b) | 32.8% 26.0% 17.1% 23.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 8/32 (25%) 5/30 (17%) 6/35 (17%) 5/28 (18%) 0/0 |
|FIRST INCIDENCE (DAYS) | 647 586 729 (T) 589 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.250N P=0.467N P=0.073N P=0.329N (e) |
|INCIDENTAL TUMOR | P=0.174N P=0.388N P=0.135N P=0.252N (e) |
|LOGISTIC REGRESSION | P=0.157N P=0.366N P=0.088N P=0.271N P=0.957N |
|COCHRAN-ARMITAGE | P=0.021N* |
|FISHER EXACT | P=0.409N P=0.105N P=0.246N P=0.017N* |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/80 (0%) 0/80 (0%) 0/80 (0%) 0/79 (0%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/30 (0%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|ADJUSTED (b) | |
|INTERIM SACRIFICE 1 (c)| |
|INTERIM SACRIFICE 2 (c)| |
|INTERIM SACRIFICE 3 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE (DAYS) | |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | |
|INCIDENTAL TUMOR | |
|LOGISTIC REGRESSION | |
|COCHRAN-ARMITAGE | |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/80 (1%) 1/80 (1%) 1/80 (1%) 1/80 (1%) 0/30 (0%) |
|ADJUSTED (b) | 2.0% 3.3% 2.1% 3.1% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 1/30 (3%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 478 729 (T) 488 702 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.746 P=0.749 P=0.756 P=0.750 (e) |
|INCIDENTAL TUMOR | P=0.710 P=0.753 P=0.712N P=0.705 (e) |
|LOGISTIC REGRESSION | P=0.574N P=0.760 P=0.761N P=0.761 P=0.737N |
|COCHRAN-ARMITAGE | P=0.487N |
|FISHER EXACT | P=0.752N P=0.752N P=0.752N P=0.727N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 0/80 (0%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/30 (0%) 0/35 (0%) 0/28 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 20/80 (25%) 18/80 (23%) 16/80 (20%) 20/80 (25%) 2/30 (7%) |
|ADJUSTED (b) | 44.3% 39.5% 37.7% 44.9% 14.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 8/32 (25%) 4/30 (13%) 9/35 (26%) 5/28 (18%) 0/0 |
|FIRST INCIDENCE (DAYS) | 486 455 (I) 553 578 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.197 P=0.514N P=0.250N P=0.441 P=0.251 |
|INCIDENTAL TUMOR | P=0.352 P=0.405N P=0.447N P=0.382N P=0.251 |
|LOGISTIC REGRESSION | P=0.503 P=0.285N P=0.415N P=0.239N P=0.682N |
|COCHRAN-ARMITAGE | P=0.069N |
|FISHER EXACT | P=0.426N P=0.285N P=0.572N P=0.025N* |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 59/80 (74%) 58/80 (73%) 57/80 (71%) 59/80 (74%) 10/30 (33%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% 100.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 10/10 (100%) 10/10 (100%) 9/10 (90%) 9/10 (90%) 10/10 (100%) |
|TERMINAL (d) | 32/32 (100%) 30/30 (100%) 35/35 (100%) 28/28 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 455 (I) 455 (I) 454 455 (I) 455 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.253 P=0.431 P=0.234N P=0.247 (e) |
|INCIDENTAL TUMOR | P=0.522 P=0.785 P=0.570N P=0.716N (e) |
|LOGISTIC REGRESSION | P=0.316 P=0.717N P=0.515N P=0.739N P=0.520 |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.500N P=0.430N P=0.571N P<0.001N** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 29/80 (36%) 24/80 (30%) 19/80 (24%) 24/80 (30%) 2/30 (7%) |
|ADJUSTED (b) | 59.6% 51.0% 42.7% 51.1% 14.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|INTERIM SACRIFICE 3 (c)| 1/10 (10%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 13/32 (41%) 8/30 (27%) 10/35 (29%) 6/28 (21%) 0/0 |
|FIRST INCIDENCE (DAYS) | 455 (I) 455 (I) 488 542 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.541 P=0.360N P=0.057N P=0.404N P=0.512 |
|INCIDENTAL TUMOR | P=0.309N P=0.208N P=0.068N P=0.081N P=0.512 |
|LOGISTIC REGRESSION | P=0.189N P=0.152N P=0.081N P=0.040N* P=0.393N |
|COCHRAN-ARMITAGE | P=0.006N** |
|FISHER EXACT | P=0.251N P=0.060N P=0.251N P=0.001N** |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 60/80 (75%) 59/80 (74%) 58/80 (73%) 59/80 (74%) 11/30 (37%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% 100.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|INTERIM SACRIFICE 3 (c)| 10/10 (100%) 10/10 (100%) 9/10 (90%) 9/10 (90%) 10/10 (100%) |
|TERMINAL (d) | 32/32 (100%) 30/30 (100%) 35/35 (100%) 28/28 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 455 (I) 455 (I) 454 455 (I) 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.203 P=0.432 P=0.242N P=0.303 P=0.521 |
|INCIDENTAL TUMOR | P=0.273 (e) P=0.500N P=0.500N P=0.521 |
|LOGISTIC REGRESSION | P=0.280 (e) P=0.522N P=0.500N P=0.521 |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.500N P=0.429N P=0.500N P<0.001N** |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/80 (1%) 1/81 (1%) 0/80 (0%) 1/80 (1%) 0/29 (0%) |
|ADJUSTED (b) | 2.9% 2.6% 0.0% 3.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 1/34 (3%) 1/38 (3%) 0/30 (0%) 1/26 (4%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- 729 (T) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.763 P=0.737N P=0.525N P=0.701 (e) |
|INCIDENTAL TUMOR | P=0.763 P=0.737N P=0.525N P=0.701 (e) |
|LOGISTIC REGRESSION | P=0.763 P=0.737N P=0.525N P=0.701 (e) |
|COCHRAN-ARMITAGE | P=0.521N |
|FISHER EXACT | P=0.748N P=0.500N P=0.752N P=0.734N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/80 (1%) 2/81 (2%) 3/80 (4%) 0/80 (0%) 0/29 (0%) |
|ADJUSTED (b) | 2.9% 4.7% 10.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 1/34 (3%) 1/38 (3%) 3/30 (10%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 620 729 (T) --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.541N P=0.544 P=0.261 P=0.553N (e) |
|INCIDENTAL TUMOR | P=0.539N P=0.432 P=0.261 P=0.554N (e) |
|LOGISTIC REGRESSION | P=0.455N P=0.526 P=0.261 P=0.554N (e) |
|COCHRAN-ARMITAGE | P=0.253N |
|FISHER EXACT | P=0.505 P=0.310 P=0.500N P=0.734N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/80 (1%) 2/81 (2%) 3/80 (4%) 1/80 (1%) 0/29 (0%) |
|ADJUSTED (b) | 2.9% 4.7% 10.0% 2.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 1/34 (3%) 1/38 (3%) 3/30 (10%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 620 729 (T) 625 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.646 P=0.544 P=0.261 P=0.734 (e) |
|INCIDENTAL TUMOR | P=0.648 P=0.432 P=0.261 P=0.713 (e) |
|LOGISTIC REGRESSION | P=0.652N P=0.526 P=0.261 P=0.756 (e) |
|COCHRAN-ARMITAGE | P=0.375N |
|FISHER EXACT | P=0.505 P=0.310 P=0.752N P=0.734N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/80 (1%) 4/81 (5%) 4/79 (5%) 3/79 (4%) 0/30 (0%) |
|ADJUSTED (b) | 2.9% 10.5% 12.8% 11.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/34 (3%) 4/38 (11%) 3/29 (10%) 3/26 (12%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 705 729 (T) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.258 P=0.214 P=0.146 P=0.214 (e) |
|INCIDENTAL TUMOR | P=0.303 P=0.214 P=0.191 P=0.214 (e) |
|LOGISTIC REGRESSION | P=0.304 P=0.214 P=0.175 P=0.214 (e) |
|COCHRAN-ARMITAGE | P=0.431N |
|FISHER EXACT | P=0.187 P=0.180 P=0.305 P=0.727N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/80 (3%) 5/81 (6%) 4/79 (5%) 3/79 (4%) 0/30 (0%) |
|ADJUSTED (b) | 5.9% 13.2% 12.8% 11.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 2/34 (6%) 5/38 (13%) 3/29 (10%) 3/26 (12%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 705 729 (T) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.428 P=0.262 P=0.280 P=0.378 (e) |
|INCIDENTAL TUMOR | P=0.477 P=0.262 P=0.342 P=0.378 (e) |
|LOGISTIC REGRESSION | P=0.482 P=0.262 P=0.328 P=0.378 (e) |
|COCHRAN-ARMITAGE | P=0.277N |
|FISHER EXACT | P=0.226 P=0.335 P=0.494 P=0.527N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/80 (0%) 0/81 (0%) 1/80 (1%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 3.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/38 (0%) 1/30 (3%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.868 (e) P=0.475 (e) (e) |
|INCIDENTAL TUMOR | P=0.868 (e) P=0.475 (e) (e) |
|LOGISTIC REGRESSION | P=0.868 (e) P=0.475 (e) (e) |
|COCHRAN-ARMITAGE | P=0.778N |
|FISHER EXACT | (e) P=0.500 (e) (e) |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/80 (0%) 1/81 (1%) 1/80 (1%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 2.6% 3.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/38 (0%) 1/30 (3%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 712 729 (T) --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.816N P=0.516 P=0.475 (e) (e) |
|INCIDENTAL TUMOR | P=0.715N P=0.567 P=0.475 (e) (e) |
|LOGISTIC REGRESSION | P=0.787N P=0.520 P=0.475 (e) (e) |
|COCHRAN-ARMITAGE | P=0.555N |
|FISHER EXACT | P=0.503 P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/80 (1%) 0/81 (0%) 1/80 (1%) 2/80 (3%) 0/30 (0%) |
|ADJUSTED (b) | 2.9% 0.0% 2.3% 7.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/34 (3%) 0/38 (0%) 0/30 (0%) 2/26 (8%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 642 729 (T) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.295 P=0.478N P=0.760 P=0.406 (e) |
|INCIDENTAL TUMOR | P=0.303 P=0.478N P=0.729 P=0.406 (e) |
|LOGISTIC REGRESSION | P=0.369 P=0.478N P=0.752N P=0.406 (e) |
|COCHRAN-ARMITAGE | P=0.600 |
|FISHER EXACT | P=0.497N P=0.752N P=0.500 P=0.727N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 3/80 (4%) 1/81 (1%) 0/80 (0%) 1/80 (1%) 0/30 (0%) |
|ADJUSTED (b) | 8.8% 1.2% 0.0% 3.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 3/34 (9%) 0/38 (0%) 0/30 (0%) 1/26 (4%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 92 (I) --- 729 (T) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.280N P=0.277N P=0.143N P=0.405N (e) |
|INCIDENTAL TUMOR | P=0.280N P=0.278N P=0.143N P=0.405N (e) |
|LOGISTIC REGRESSION | P=0.221N P=0.300N P=0.143N P=0.405N (e) |
|COCHRAN-ARMITAGE | P=0.188N |
|FISHER EXACT | P=0.305N P=0.123N P=0.310N P=0.381N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 3/80 (4%) 2/81 (2%) 0/80 (0%) 1/80 (1%) 0/30 (0%) |
|ADJUSTED (b) | 8.8% 2.7% 0.0% 3.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 3/34 (9%) 0/38 (0%) 0/30 (0%) 1/26 (4%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 92 (I) --- 729 (T) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.188N P=0.470N P=0.143N P=0.405N (e) |
|INCIDENTAL TUMOR | P=0.188N P=0.470N P=0.143N P=0.405N (e) |
|LOGISTIC REGRESSION | P=0.154N P=0.495N P=0.143N P=0.405N (e) |
|COCHRAN-ARMITAGE | P=0.148N |
|FISHER EXACT | P=0.494N P=0.123N P=0.310N P=0.381N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 15/80 (19%) 16/81 (20%) 21/80 (26%) 15/80 (19%) 0/30 (0%) |
|ADJUSTED (b) | 36.0% 37.9% 52.1% 42.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 8/34 (24%) 12/38 (32%) 11/30 (37%) 8/26 (31%) 0/0 |
|FIRST INCIDENCE (DAYS) | 557 653 592 564 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.238 P=0.522N P=0.141 P=0.391 (e) |
|INCIDENTAL TUMOR | P=0.420N P=0.560 P=0.391 P=0.482N (e) |
|LOGISTIC REGRESSION | P=0.522N P=0.535 P=0.276 P=0.479N P=0.398N |
|COCHRAN-ARMITAGE | P=0.023N* |
|FISHER EXACT | P=0.515 P=0.172 P=0.580N P=0.006N** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 18/80 (23%) 17/81 (21%) 21/80 (26%) 16/80 (20%) 0/30 (0%) |
|ADJUSTED (b) | 43.4% 38.7% 52.1% 46.1% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 11/34 (32%) 12/38 (32%) 11/30 (37%) 9/26 (35%) 0/0 |
|FIRST INCIDENCE (DAYS) | 557 92 (I) 592 564 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.387 P=0.360N P=0.290 P=0.505 (e) |
|INCIDENTAL TUMOR | P=0.266N P=0.429N P=0.537N P=0.357N (e) |
|LOGISTIC REGRESSION | P=0.359N P=0.409N P=0.523 P=0.328N P=0.415N |
|COCHRAN-ARMITAGE | P=0.010N* |
|FISHER EXACT | P=0.483N P=0.356 P=0.423N P=0.002N** |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 18/80 (23%) 18/81 (22%) 21/80 (26%) 16/80 (20%) 0/30 (0%) |
|ADJUSTED (b) | 43.4% 39.6% 52.1% 46.1% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 11/34 (32%) 12/38 (32%) 11/30 (37%) 9/26 (35%) 0/0 |
|FIRST INCIDENCE (DAYS) | 557 92 (I) 592 564 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.459 P=0.434N P=0.290 P=0.505 (e) |
|INCIDENTAL TUMOR | P=0.213N P=0.513N P=0.537N P=0.357N (e) |
|LOGISTIC REGRESSION | P=0.294N P=0.501N P=0.523 P=0.328N P=0.415N |
|COCHRAN-ARMITAGE | P=0.009N** |
|FISHER EXACT | P=0.558N P=0.356 P=0.423N P=0.002N** |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 30/80 (38%) 26/81 (32%) 27/80 (34%) 24/80 (30%) 3/30 (10%) |
|ADJUSTED (b) | 66.7% 56.2% 63.0% 58.7% 33.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 1/8 (13%) 2/10 (20%) 1/10 (10%) 3/9 (33%) |
|TERMINAL (d) | 19/34 (56%) 18/38 (47%) 15/30 (50%) 11/26 (42%) 0/0 |
|FIRST INCIDENCE (DAYS) | 553 456 (I) 456 (I) 353 456 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.256 P=0.160N P=0.465N P=0.454N P=0.109 |
|INCIDENTAL TUMOR | P=0.394N P=0.232N P=0.124N P=0.088N P=0.109 |
|LOGISTIC REGRESSION | P=0.460N P=0.287N P=0.223N P=0.153N P=0.285 |
|COCHRAN-ARMITAGE | P=0.006N** |
|FISHER EXACT | P=0.290N P=0.371N P=0.202N P=0.003N** |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 26
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Adenoma or Basosquamous Tumor Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 0/81 (0%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/38 (0%) 0/30 (0%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Adenoma, Basosquamous Tumor Benign, or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 0/81 (0%) 0/80 (0%) 1/80 (1%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 1.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 1/10 (10%) 0/9 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/38 (0%) 0/30 (0%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 456 (I) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.646 (e) (e) P=0.521 (e) |
|INCIDENTAL TUMOR | P=0.646 (e) (e) P=0.521 (e) |
|LOGISTIC REGRESSION | P=0.569 (e) (e) P=0.503 (e) |
|COCHRAN-ARMITAGE | P=0.550 |
|FISHER EXACT | (e) (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 27
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, |
| malignant or NOS), or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 0/81 (0%) 0/80 (0%) 1/80 (1%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 1.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 1/10 (10%) 0/9 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/38 (0%) 0/30 (0%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 456 (I) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.646 (e) (e) P=0.521 (e) |
|INCIDENTAL TUMOR | P=0.646 (e) (e) P=0.521 (e) |
|LOGISTIC REGRESSION | P=0.569 (e) (e) P=0.503 (e) |
|COCHRAN-ARMITAGE | P=0.550 |
|FISHER EXACT | (e) (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/80 (1%) 0/81 (0%) 0/80 (0%) 2/80 (3%) 0/30 (0%) |
|ADJUSTED (b) | 2.9% 0.0% 0.0% 5.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 1/10 (10%) 0/9 (0%) |
|TERMINAL (d) | 1/34 (3%) 0/38 (0%) 0/30 (0%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- 456 (I) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.527 P=0.478N P=0.525N P=0.456 (e) |
|INCIDENTAL TUMOR | P=0.604 P=0.478N P=0.525N P=0.594 (e) |
|LOGISTIC REGRESSION | P=0.487 P=0.478N P=0.525N P=0.493 (e) |
|COCHRAN-ARMITAGE | P=0.586 |
|FISHER EXACT | P=0.497N P=0.500N P=0.500 P=0.727N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 28
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 0/81 (0%) 3/80 (4%) 1/80 (1%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.3% 2.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 1/10 (10%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/38 (0%) 0/30 (0%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 372 691 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.534 (e) P=0.126 P=0.489 (e) |
|INCIDENTAL TUMOR | P=0.627 (e) P=0.089 P=0.705 (e) |
|LOGISTIC REGRESSION | P=0.564 (e) P=0.121 P=0.493 (e) |
|COCHRAN-ARMITAGE | P=0.600 |
|FISHER EXACT | (e) P=0.123 P=0.500 (e) |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 0/81 (0%) 2/80 (3%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 3.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 1/10 (10%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/38 (0%) 0/30 (0%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 372 --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.612N (e) P=0.253 (e) (e) |
|INCIDENTAL TUMOR | P=0.623N (e) P=0.113 (e) (e) |
|LOGISTIC REGRESSION | P=0.620N (e) P=0.232 (e) (e) |
|COCHRAN-ARMITAGE | P=0.675N |
|FISHER EXACT | (e) P=0.248 (e) (e) |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 29
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 0/81 (0%) 3/80 (4%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 1/10 (10%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/38 (0%) 0/30 (0%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 372 --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.644N (e) P=0.126 (e) (e) |
|INCIDENTAL TUMOR | P=0.588N (e) P=0.089 (e) (e) |
|LOGISTIC REGRESSION | P=0.625N (e) P=0.121 (e) (e) |
|COCHRAN-ARMITAGE | P=0.617N |
|FISHER EXACT | (e) P=0.123 (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 0/81 (0%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/38 (0%) 0/30 (0%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 30
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/80 (1%) 0/81 (0%) 0/80 (0%) 1/80 (1%) 0/30 (0%) |
|ADJUSTED (b) | 2.9% 0.0% 0.0% 3.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/34 (3%) 0/38 (0%) 0/30 (0%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- 722 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.723 P=0.478N P=0.525N P=0.705 (e) |
|INCIDENTAL TUMOR | P=0.823 P=0.478N P=0.525N P=0.691N (e) |
|LOGISTIC REGRESSION | P=0.745 P=0.478N P=0.525N P=0.736 (e) |
|COCHRAN-ARMITAGE | P=0.675N |
|FISHER EXACT | P=0.497N P=0.500N P=0.752N P=0.727N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 0/81 (0%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/38 (0%) 0/30 (0%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 31
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|ADJUSTED (b) | |
|INTERIM SACRIFICE 1 (c)| |
|INTERIM SACRIFICE 2 (c)| |
|INTERIM SACRIFICE 3 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE (DAYS) | |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | |
|INCIDENTAL TUMOR | |
|LOGISTIC REGRESSION | |
|COCHRAN-ARMITAGE | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 10/80 (13%) 8/81 (10%) 3/80 (4%) 11/80 (14%) 0/30 (0%) |
|ADJUSTED (b) | 23.7% 19.9% 7.5% 34.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 1/9 (11%) 1/8 (13%) 1/10 (10%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 5/34 (15%) 7/38 (18%) 1/30 (3%) 6/26 (23%) 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 456 (I) 670 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.499 P=0.335N P=0.047N* P=0.345 P=0.500N |
|INCIDENTAL TUMOR | P=0.481N P=0.434N P=0.052N P=0.515 P=0.284N |
|LOGISTIC REGRESSION | P=0.547N P=0.354N P=0.035N* P=0.472 P=0.280N |
|COCHRAN-ARMITAGE | P=0.141N |
|FISHER EXACT | P=0.391N P=0.040N* P=0.500 P=0.035N* |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 32
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 10/80 (13%) 8/81 (10%) 3/80 (4%) 12/80 (15%) 0/30 (0%) |
|ADJUSTED (b) | 23.7% 19.9% 7.5% 37.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 1/9 (11%) 1/8 (13%) 1/10 (10%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 5/34 (15%) 7/38 (18%) 1/30 (3%) 7/26 (27%) 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 456 (I) 670 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.391 P=0.335N P=0.047N* P=0.258 P=0.500N |
|INCIDENTAL TUMOR | P=0.587 P=0.434N P=0.052N P=0.403 P=0.284N |
|LOGISTIC REGRESSION | P=0.530 P=0.354N P=0.035N* P=0.377 P=0.280N |
|COCHRAN-ARMITAGE | P=0.179N |
|FISHER EXACT | P=0.391N P=0.040N* P=0.409 P=0.035N* |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/80 (0%) 1/81 (1%) 2/80 (3%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 2.6% 5.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 1/10 (10%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/34 (0%) 1/38 (3%) 1/30 (3%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 456 (I) --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.592N P=0.522 P=0.237 (e) (e) |
|INCIDENTAL TUMOR | P=0.592N P=0.522 P=0.237 (e) (e) |
|LOGISTIC REGRESSION | P=0.641N P=0.522 P=0.242 (e) (e) |
|COCHRAN-ARMITAGE | P=0.516N |
|FISHER EXACT | P=0.503 P=0.248 (e) (e) |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 33
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 7/80 (9%) 2/81 (2%) 8/80 (10%) 9/80 (11%) 1/30 (3%) |
|ADJUSTED (b) | 18.4% 4.3% 23.8% 30.4% 11.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 1/9 (11%) 1/8 (13%) 0/10 (0%) 0/10 (0%) 1/9 (11%) |
|TERMINAL (d) | 5/34 (15%) 1/38 (3%) 6/30 (20%) 7/26 (27%) 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 619 550 456 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.063 P=0.070N P=0.444 P=0.245 P=0.767 |
|INCIDENTAL TUMOR | P=0.097 P=0.065N P=0.520 P=0.321 P=0.767 |
|LOGISTIC REGRESSION | P=0.095 P=0.072N P=0.544 P=0.366 P=0.594 |
|COCHRAN-ARMITAGE | P=0.557 |
|FISHER EXACT | P=0.081N P=0.500 P=0.397 P=0.303N |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 2/81 (2%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 4.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/38 (0%) 0/30 (0%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 397 --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.549N P=0.260 (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.492N P=0.196 (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.446N P=0.241 (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.429N |
|FISHER EXACT | P=0.252 (e) (e) (e) |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 34
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/80 (0%) 2/81 (2%) 0/80 (0%) 0/80 (0%) 0/30 (0%) |
|ADJUSTED (b) | 0.0% 4.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/34 (0%) 1/38 (3%) 0/30 (0%) 0/26 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 222 --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.541N P=0.254 (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.551N P=0.368 (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.412N P=0.240 (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.429N |
|FISHER EXACT | P=0.252 (e) (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 8/80 (10%) 8/81 (10%) 13/80 (16%) 15/80 (19%) 0/30 (0%) |
|ADJUSTED (b) | 22.7% 18.9% 29.6% 39.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 7/34 (21%) 5/38 (13%) 3/30 (10%) 5/26 (19%) 0/0 |
|FIRST INCIDENCE (DAYS) | 675 464 592 546 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.016 * P=0.512N P=0.174 P=0.041 * (e) |
|INCIDENTAL TUMOR | P=0.144 P=0.518N P=0.320 P=0.151 (e) |
|LOGISTIC REGRESSION | P=0.093 P=0.535N P=0.434 P=0.064 P=1.000N |
|COCHRAN-ARMITAGE | P=0.376N |
|FISHER EXACT | P=0.593N P=0.175 P=0.088 P=0.071N |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 35
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 47/80 (59%) 36/81 (44%) 42/80 (53%) 44/80 (55%) 4/30 (13%) |
|ADJUSTED (b) | 94.0% 71.4% 85.5% 93.4% 44.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 2/9 (22%) 3/8 (38%) 4/10 (40%) 2/10 (20%) 4/9 (44%) |
|TERMINAL (d) | 31/34 (91%) 24/38 (63%) 23/30 (77%) 23/26 (88%) 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) 92 (I) 456 (I) 353 456 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.074 P=0.013N* P=0.394N P=0.291 P=0.314 |
|INCIDENTAL TUMOR | P=0.501 P=0.012N* P=0.043N* P=0.346N P=0.465 |
|LOGISTIC REGRESSION | P=0.419 P=0.007N** P=0.068N P=0.365N P=0.475 |
|COCHRAN-ARMITAGE | P=0.001N** |
|FISHER EXACT | P=0.048N* P=0.262N P=0.375N P<0.001N** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 14/80 (18%) 16/81 (20%) 18/80 (23%) 20/80 (25%) 0/30 (0%) |
|ADJUSTED (b) | 34.8% 32.4% 37.9% 49.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/8 (0%) 1/10 (10%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 10/34 (29%) 7/38 (18%) 4/30 (13%) 7/26 (27%) 0/0 |
|FIRST INCIDENCE (DAYS) | 274 (I) 222 372 546 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.152 P=0.530 P=0.269 P=0.077 P=0.406N |
|INCIDENTAL TUMOR | P=0.535 P=0.510 P=0.297 P=0.183 P=0.284N |
|LOGISTIC REGRESSION | P=0.541N P=0.461 P=0.309 P=0.133 P=0.218N |
|COCHRAN-ARMITAGE | P=0.102N |
|FISHER EXACT | P=0.435 P=0.277 P=0.167 P=0.008N** |
|=================================================================================================================================|
DATE: 11/10/95 EXPERIMENT: 05100 TEST: 03 PAGE 36
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | 0 PPM 75 PPM 150 PPM 300 PPM 600 PPM |
| | 23 STOP |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 50/80 (63%) 44/81 (54%) 48/80 (60%) 48/80 (60%) 4/30 (13%) |
|ADJUSTED (b) | 96.1% 79.5% 88.7% 96.0% 44.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 2/9 (22%) 3/8 (38%) 5/10 (50%) 2/10 (20%) 4/9 (44%) |
|TERMINAL (d) | 32/34 (94%) 27/38 (71%) 24/30 (80%) 24/26 (92%) 0/0 |
|FIRST INCIDENCE (DAYS) | 274 (I) 92 (I) 372 353 456 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.139 P=0.082N P=0.550 P=0.227 P=0.548 |
|INCIDENTAL TUMOR | P=0.446N P=0.121N P=0.251N P=0.520N P=0.626N |
|LOGISTIC REGRESSION | P=0.376N P=0.094N P=0.239N P=0.477N P=0.507N |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.186N P=0.436N P=0.436N P<0.001N** |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 92 273 455
Female interim sacrifices(days): 92 274 456
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).