TDMS Study 05100-03 Pathology Tables
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1330-78-5
Lock Date: 12/30/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 0| 2| 2| 0| 4| 4| 2| 0| 2| 4| 0| 4| 2| 4| 4| 2| 0| 2| 0| 2| 2| 0| 2| 4|
DAY ON TEST | 7| 9| 7| 7| 9| 5| 5| 7| 9| 7| 5| 9| 5| 7| 1| 5| 7| 9| 7| 9| 7| 7| 9| 7| 5|
| 4| 2| 4| 4| 2| 6| 6| 4| 7| 8| 7| 7| 6| 4| 2| 7| 4| 2| 4| 3| 4| 8| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Cyst | X |
Degeneration, Cystic | |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Acinus, Atrophy | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Myocardium, Degeneration | 1 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 0| 2| 2| 0| 4| 4| 2| 0| 2| 4| 0| 4| 2| 4| 4| 2| 0| 2| 0| 2| 2| 0| 2| 4|
DAY ON TEST | 7| 9| 7| 7| 9| 5| 5| 7| 9| 7| 5| 9| 5| 7| 1| 5| 7| 9| 7| 9| 7| 7| 9| 7| 5|
| 4| 2| 4| 4| 2| 6| 6| 4| 7| 8| 7| 7| 6| 4| 2| 7| 4| 2| 4| 3| 4| 8| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + +|
Abscess | |
Hyperplasia | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Prolapse | |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 0| 2| 2| 0| 4| 4| 2| 0| 2| 4| 0| 4| 2| 4| 4| 2| 0| 2| 0| 2| 2| 0| 2| 4|
DAY ON TEST | 7| 9| 7| 7| 9| 5| 5| 7| 9| 7| 5| 9| 5| 7| 1| 5| 7| 9| 7| 9| 7| 7| 9| 7| 5|
| 4| 2| 4| 4| 2| 6| 6| 4| 7| 8| 7| 7| 6| 4| 2| 7| 4| 2| 4| 3| 4| 8| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy | 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 4| 2| 4| 2| 4| 0| 4| 4| 4| 2| 4| 0| 0| 0| 0| 2| 4| 0| 0| 7| 5| 7| 7| 7|
DAY ON TEST | 9| 5| 7| 5| 7| 5| 9| 5| 5| 5| 7| 5| 9| 9| 9| 9| 7| 5| 9| 9| 3| 3| 2| 3| 3|
| 2| 6| 8| 7| 4| 7| 2| 6| 6| 6| 8| 6| 3| 3| 7| 3| 8| 7| 7| 7| 1| 7| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7|
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + +|
Basophilic Focus | X X|
Clear Cell Focus | |
Cyst | |
Degeneration, Cystic | |
Eosinophilic Focus | X X|
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous | |
Mixed Cell Focus | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Acinus, Atrophy | 1 1 1 1 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Degeneration | 1 |
Myocardium, Degeneration | 1 2 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
Vacuolization Cytoplasmic | 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 4| 2| 4| 2| 4| 0| 4| 4| 4| 2| 4| 0| 0| 0| 0| 2| 4| 0| 0| 7| 5| 7| 7| 7|
DAY ON TEST | 9| 5| 7| 5| 7| 5| 9| 5| 5| 5| 7| 5| 9| 9| 9| 9| 7| 5| 9| 9| 3| 3| 2| 3| 3|
| 2| 6| 8| 7| 4| 7| 2| 6| 6| 6| 8| 6| 3| 3| 7| 3| 8| 7| 7| 7| 1| 7| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7|
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + +|
Abscess | |
Hyperplasia | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + +|
Dilatation | |
Prolapse | X |
Endometrium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + M + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 4| 2| 4| 2| 4| 0| 4| 4| 4| 2| 4| 0| 0| 0| 0| 2| 4| 0| 0| 7| 5| 7| 7| 7|
DAY ON TEST | 9| 5| 7| 5| 7| 5| 9| 5| 5| 5| 7| 5| 9| 9| 9| 9| 7| 5| 9| 9| 3| 3| 2| 3| 3|
| 2| 6| 8| 7| 4| 7| 2| 6| 6| 6| 8| 6| 3| 3| 7| 3| 8| 7| 7| 7| 1| 7| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7|
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | X |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy | 1 2 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 6| 5| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 3| 7| 3| 3| 3| 3| 9|
| 2| 2| 7| 3| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | |
Cyst | X |
Degeneration, Cystic | 1 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Granulomatous | 3 |
Mixed Cell Focus | X X X |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 1 2 1 1 3 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Myocardium, Degeneration | 2 1 2 1 1 2 3 1 2 2 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 1 2 1 1 1|
Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 6| 5| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 3| 7| 3| 3| 3| 3| 9|
| 2| 2| 7| 3| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 2 3 2 3 2 2 4 3 2 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Hyperplasia | 2 2 |
Inflammation, Chronic | 2 2 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Prolapse | X |
Endometrium, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 6| 5| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 3| 7| 3| 3| 3| 3| 9|
| 2| 2| 7| 3| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | X X X X X X X X|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Nephropathy | 1 2 1 1 1 1 2 3 3 1 1 1 1 1 1 1 1 1 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 6| 1| 7| 7| 5| 7| 5| 7| 7| 7| | |
DAY ON TEST | 3| 3| 7| 6| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 0| 3| 3| 3| | |
| 2| 2| 8| 4| 2| 2| 2| 2| 2| 2| 8| 4| 2| 2| 7| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 80 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 80 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 80 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 79 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 80 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 80 |
Basophilic Focus | X X X X X X X X X X X | 21 |
Clear Cell Focus | X | 1 |
Cyst | | 2 |
Degeneration, Cystic | | 1 1.0|
Eosinophilic Focus | X | 3 |
Hepatodiaphragmatic Nodule | X | 7 |
Inflammation, Granulomatous | | 2 2.0|
Mixed Cell Focus | X X | 5 |
Serosa, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis | 2 | 4 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic | | 3 1.0|
Acinus, Atrophy | 1 1 1 1 | 17 1.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 80 |
Degeneration | | 1 1.0|
Myocardium, Degeneration | 1 1 1 2 1 1 2 1 2 2 2 1 2 1 | 37 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 6| 1| 7| 7| 5| 7| 5| 7| 7| 7| | |
DAY ON TEST | 3| 3| 7| 6| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 0| 3| 3| 3| | |
| 2| 2| 8| 4| 2| 2| 2| 2| 2| 2| 8| 4| 2| 2| 7| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 1 1 3 1 2 1 1 | 18 1.4|
Vacuolization Cytoplasmic | 1 1 1 1 | 15 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 2 1 2 | 6 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + | 75 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst | X | 1 |
Pars Distalis, Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
C-Cell, Hyperplasia | 3 3 3 1 3 2 3 3 3 2 2 2 2 2 | 37 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
Abscess | | 1 4.0|
Hyperplasia | 2 2 2 | 5 2.0|
Inflammation, Chronic | 2 2 | 5 1.8|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 80 |
Dilatation | | 2 2.5|
Prolapse | | 2 |
Endometrium, Hyperplasia | 2 2 2 1 | 7 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Lymph Node | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 79 |
Fibrosis | 1 | 1 1.0|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 6| 1| 7| 7| 5| 7| 5| 7| 7| 7| | |
DAY ON TEST | 3| 3| 7| 6| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 0| 3| 3| 3| | |
| 2| 2| 8| 4| 2| 2| 2| 2| 2| 2| 8| 4| 2| 2| 7| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + | 77 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + M + + + + + + + + + + + | 77 |
Hyperplasia, Cystic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 80 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 80 |
Osteopetrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 80 |
Hypothalamus, Compression | X X X X | 13 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 95 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 95 |
Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic | 2 | 5 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 80 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 80 |
Infarct | | 1 2.0|
Nephropathy | 2 1 4 1 1 1 1 2 1 1 1 1 3 1 | 46 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 4| 0| 2| 0| 4| 0| 4| 2| 0| 2| 0| 4| 0| 2|
DAY ON TEST | 7| 7| 7| 5| 5| 7| 9| 7| 7| 9| 9| 5| 9| 7| 9| 5| 9| 5| 0| 9| 7| 9| 5| 9| 7|
| 4| 4| 8| 7| 6| 4| 3| 8| 4| 3| 2| 7| 7| 8| 2| 7| 2| 6| 4| 3| 4| 3| 6| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +|
Peyer's Patch, Mineralization | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | |
Fatty Change | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Granulomatous | 1 1 1 1|
Mixed Cell Focus | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + +|
Mucosa, Mineralization | |
__________________________________________________________________________|
Tongue | |
Mucosa, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
Myocardium, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + +|
Infarct | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 4| 0| 2| 0| 4| 0| 4| 2| 0| 2| 0| 4| 0| 2|
DAY ON TEST | 7| 7| 7| 5| 5| 7| 9| 7| 7| 9| 9| 5| 9| 7| 9| 5| 9| 5| 0| 9| 7| 9| 5| 9| 7|
| 4| 4| 8| 7| 6| 4| 3| 8| 4| 3| 2| 7| 7| 8| 2| 7| 2| 6| 4| 3| 4| 3| 6| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + +|
Cervix, Cyst | |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 4| 0| 2| 0| 4| 0| 4| 2| 0| 2| 0| 4| 0| 2|
DAY ON TEST | 7| 7| 7| 5| 5| 7| 9| 7| 7| 9| 9| 5| 9| 7| 9| 5| 9| 5| 0| 9| 7| 9| 5| 9| 7|
| 4| 4| 8| 7| 6| 4| 3| 8| 4| 3| 2| 7| 7| 8| 2| 7| 2| 6| 4| 3| 4| 3| 6| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Hemorrhage | |
Cornea, Inflammation, Chronic | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 2| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 2| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 8| 9| 5| 5| 5| 9| 5| 5| 7| 9| 5| 9| 2| 7| 7| 7| 5| 9| 7| 3| 3| 3| 3| 3|
| 7| 5| 7| 6| 7| 6| 7| 6| 6| 4| 3| 6| 2| 2| 8| 4| 4| 7| 2| 4| 0| 0| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|
75 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Mineralization | 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Eosinophilic Focus | X|
Fatty Change | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | X |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Mucosa, Mineralization | |
__________________________________________________________________________|
Tongue | |
Mucosa, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
Myocardium, Degeneration | 2 1 3 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + +|
Infarct | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 2| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 2| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 8| 9| 5| 5| 5| 9| 5| 5| 7| 9| 5| 9| 2| 7| 7| 7| 5| 9| 7| 3| 3| 3| 3| 3|
| 7| 5| 7| 6| 7| 6| 7| 6| 6| 4| 3| 6| 2| 2| 8| 4| 4| 7| 2| 4| 0| 0| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|
75 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 2 2 2 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Cervix, Cyst | X |
Endometrium, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 2| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 2| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 8| 9| 5| 5| 5| 9| 5| 5| 7| 9| 5| 9| 2| 7| 7| 7| 5| 9| 7| 3| 3| 3| 3| 3|
| 7| 5| 7| 6| 7| 6| 7| 6| 6| 4| 3| 6| 2| 2| 8| 4| 4| 7| 2| 4| 0| 0| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|
75 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + M + + + + + + + + + + + +|
Axon, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Hemorrhage | |
Cornea, Inflammation, Chronic | |
Lens, Cataract | 3|
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 3| 6| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 9| 2| 3| 3|
| 7| 1| 1| 1| 1| 1| 9| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 3| 7| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
75 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 3 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Mineralization | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X |
Eosinophilic Focus | |
Fatty Change | |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Granulomatous | 2 |
Mixed Cell Focus | X X |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 2 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Mineralization | 2 |
__________________________________________________________________________|
Tongue | |
Mucosa, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 2 |
Myocardium, Degeneration | 1 2 2 1 3 1 2 2 2 1 1 1 1 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 2 2 1 2 2 |
Vacuolization Cytoplasmic | 1 1 1 3 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 3| 6| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 9| 2| 3| 3|
| 7| 1| 1| 1| 1| 1| 9| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 3| 7| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
75 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 2 3 1 3 2 2 2 4 2 1 2 2 2 2 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | 3 3 2 2|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Cyst | |
Endometrium, Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + M + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 3| 6| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 9| 2| 3| 3|
| 7| 1| 1| 1| 1| 1| 9| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 3| 7| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
75 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | X |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Hemorrhage | 3 |
Cornea, Inflammation, Chronic | 2 |
Lens, Cataract | 3 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 5| 0| 3| 3| 1| 3| | |
| 1| 1| 0| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 1| 8| 1| 1| 1| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
75 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 81 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 81 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 81 |
Inflammation, Necrotizing | | 1 3.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 81 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + M + + + + + + + + + + + | 80 |
Peyer's Patch, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 81 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 81 |
Basophilic Focus | X X X X X X X X | 21 |
Eosinophilic Focus | X X | 3 |
Fatty Change | 2 3 | 2 2.5|
Hepatodiaphragmatic Nodule | X X | 11 |
Inflammation, Granulomatous | | 6 1.2|
Mixed Cell Focus | X | 4 |
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Fat, Necrosis | 3 | 5 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 81 |
Acinus, Atrophy | 1 1 1 1 1 1 | 12 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 81 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 81 |
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 81 |
Mucosa, Mineralization | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Mucosa, Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation, | | |
Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 81 |
Artery, Inflammation, Chronic | | 1 2.0|
Myocardium, Degeneration | 1 1 2 3 2 2 1 1 1 1 1 1 1 | 36 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 81 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 5| 0| 3| 3| 1| 3| | |
| 1| 1| 0| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 1| 8| 1| 1| 1| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
75 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 2 2 1 | 14 1.8|
Vacuolization Cytoplasmic | 1 1 1 1 1 | 13 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 81 |
Infarct | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 81 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + M + + + + + M + M | 76 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 81 |
Cyst | X | 5 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 1 1 3 | 6 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 81 |
C-Cell, Hyperplasia | 2 2 1 2 4 2 2 2 2 2 2 2 1 2 3 3 | 44 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + | 81 |
Hyperplasia | 2 2 | 2 2.0|
Inflammation, Chronic | | 5 2.2|
Inflammation, Chronic Active | | 2 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 81 |
Cyst | X X | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 81 |
Cervix, Cyst | X | 2 |
Endometrium, Hyperplasia | 1 | 6 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 81 |
__________________________________________________________________________|____________|
Lymph Node | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 81 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 81 |
Fibrosis | 2 | 2 2.0|
Inflammation, Granulomatous | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + + + M + M + | 74 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 5| 0| 3| 3| 1| 3| | |
| 1| 1| 0| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 1| 8| 1| 1| 1| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
75 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 81 |
Hyperplasia, Cystic | 3 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 81 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 81 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 81 |
Hypothalamus, Compression | X X X X | 5 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 95 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + M + + + + + + + | 93 |
Axon, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 81 |
Inflammation, Chronic | | 6 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 81 |
Inflammation, Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 81 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 5 |
Hemorrhage | | 1 3.0|
Cornea, Inflammation, Chronic | | 1 2.0|
Lens, Cataract | 3 | 3 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
Inflammation, Chronic Active | | 2 1.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 81 |
Nephropathy | 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 41 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 81 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 4| 2| 4| 4| 2| 0| 4| 0| 0| 2| 0| 0| 0| 2| 4| 0| 4| 4| 0| 2| 0| 4| 2| 0|
DAY ON TEST | 7| 5| 7| 5| 5| 7| 9| 5| 9| 9| 7| 9| 9| 9| 7| 5| 9| 5| 5| 9| 7| 9| 5| 7| 9|
| 4| 7| 8| 6| 6| 4| 7| 6| 3| 7| 4| 3| 3| 2| 4| 6| 7| 6| 7| 2| 8| 3| 7| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + |
Basophilic Focus | X X |
Clear Cell Focus | |
Degeneration, Cystic | |
Eosinophilic Focus | |
Fatty Change | |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + |
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + |
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + |
Ulcer | |
Mucosa, Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + |
Degeneration | |
Myocardium, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + |
Hyperplasia | |
Mineralization | |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 4| 2| 4| 4| 2| 0| 4| 0| 0| 2| 0| 0| 0| 2| 4| 0| 4| 4| 0| 2| 0| 4| 2| 0|
DAY ON TEST | 7| 5| 7| 5| 5| 7| 9| 5| 9| 9| 7| 9| 9| 9| 7| 5| 9| 5| 5| 9| 7| 9| 5| 7| 9|
| 4| 7| 8| 6| 6| 4| 7| 6| 3| 7| 4| 3| 3| 2| 4| 6| 7| 6| 7| 2| 8| 3| 7| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + M M + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + |
Cyst | |
Pigmentation, Hemosiderin | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 2 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + |
Cyst | |
Interstitium, Hyperplasia | 1 1 1 1 1 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + |
Dilatation | |
Endometrium, Hyperplasia | |
Wall, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Anisocytosis | |
Polychromasia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + |
Atrophy | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + |
Congestion | |
Erythrophagocytosis | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + |
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 4| 2| 4| 4| 2| 0| 4| 0| 0| 2| 0| 0| 0| 2| 4| 0| 4| 4| 0| 2| 0| 4| 2| 0|
DAY ON TEST | 7| 5| 7| 5| 5| 7| 9| 5| 9| 9| 7| 9| 9| 9| 7| 5| 9| 5| 5| 9| 7| 9| 5| 7| 9|
| 4| 7| 8| 6| 6| 4| 7| 6| 3| 7| 4| 3| 3| 2| 4| 6| 7| 6| 7| 2| 8| 3| 7| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Abscess | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + |
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + |
Hypothalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Fat, Mediastinum, Necrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + |
Nephropathy | 1 1 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 7| 7| 7| 6| 7|
DAY ON TEST | 5| 9| 5| 9| 5| 5| 5| 9| 7| 5| 7| 7| 5| 9| 7| 7| 7| 7| 7| 9| 2| 2| 2| 7| 2|
| 6| 2| 6| 2| 6| 6| 7| 2| 8| 6| 4| 4| 7| 7| 8| 4| 4| 4| 4| 3| 9| 9| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 8| 8| 8|
150 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X|
Clear Cell Focus | |
Degeneration, Cystic | |
Eosinophilic Focus | X|
Fatty Change | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous | |
Mixed Cell Focus | X X|
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Mucosa, Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
Myocardium, Degeneration | 1 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 |
Mineralization | 2 |
Vacuolization Cytoplasmic | 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 7| 7| 7| 6| 7|
DAY ON TEST | 5| 9| 5| 9| 5| 5| 5| 9| 7| 5| 7| 7| 5| 9| 7| 7| 7| 7| 7| 9| 2| 2| 2| 7| 2|
| 6| 2| 6| 2| 6| 6| 7| 2| 8| 6| 4| 4| 7| 7| 8| 4| 4| 4| 4| 3| 9| 9| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 8| 8| 8|
150 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pigmentation, Hemosiderin | 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 3 3 2 3 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Interstitium, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Endometrium, Hyperplasia | |
Wall, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Anisocytosis | |
Polychromasia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Erythrophagocytosis | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 7| 7| 7| 6| 7|
DAY ON TEST | 5| 9| 5| 9| 5| 5| 5| 9| 7| 5| 7| 7| 5| 9| 7| 7| 7| 7| 7| 9| 2| 2| 2| 7| 2|
| 6| 2| 6| 2| 6| 6| 7| 2| 8| 6| 4| 4| 7| 7| 8| 4| 4| 4| 4| 3| 9| 9| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 8| 8| 8|
150 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Abscess | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | X X |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Fat, Mediastinum, Necrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 4| 1| 7| 3| 3| 3| 6| 0| 1| 1| 3| 3| 0| 0| 3| 3| 3| 3| 3| 5| 3| 3| 3|
| 9| 0| 2| 2| 0| 0| 0| 0| 6| 5| 9| 1| 0| 0| 5| 5| 0| 0| 7| 0| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
150 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + M + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | 1 |
Eosinophilic Focus | X X |
Fatty Change | 3 |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous | |
Mixed Cell Focus | X X |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 1 1 3 1 1 1 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + + + + + +|
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
Mucosa, Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Myocardium, Degeneration | 1 2 1 1 1 3 2 2 1 2 2 2 1 2 1 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 2 2 1 |
Mineralization | |
Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 4| 1| 7| 3| 3| 3| 6| 0| 1| 1| 3| 3| 0| 0| 3| 3| 3| 3| 3| 5| 3| 3| 3|
| 9| 0| 2| 2| 0| 0| 0| 0| 6| 5| 9| 1| 0| 0| 5| 5| 0| 0| 7| 0| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
150 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Pigmentation, Hemosiderin | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 2 2 3 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 2 2 2 3 2 3 1 2 2 2 2 3 3 2 1 3 2 2 3 4|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Interstitium, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Endometrium, Hyperplasia | 2 |
Wall, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Anisocytosis | X |
Polychromasia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Erythrophagocytosis | 3 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 4| 1| 7| 3| 3| 3| 6| 0| 1| 1| 3| 3| 0| 0| 3| 3| 3| 3| 3| 5| 3| 3| 3|
| 9| 0| 2| 2| 0| 0| 0| 0| 6| 5| 9| 1| 0| 0| 5| 5| 0| 0| 7| 0| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
150 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Abscess | 3 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | X X X|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Fat, Mediastinum, Necrosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 6| 5| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 2| 3| 3| 3| 0| 3| 3| 2| 7| 3| 9| 9| 3| 3| 3| 3| 0| 3| | |
| 0| 2| 4| 0| 0| 0| 5| 0| 0| 4| 2| 0| 7| 2| 0| 0| 0| 0| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 79 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + M + + | 78 |
Parasite Metazoan | X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 80 |
Basophilic Focus | X X X X X X X X X | 25 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | | 1 1.0|
Eosinophilic Focus | | 3 |
Fatty Change | 2 | 2 2.5|
Hepatodiaphragmatic Nodule | X X | 4 |
Inflammation, Granulomatous | 2 | 2 1.5|
Mixed Cell Focus | X | 5 |
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Fat, Necrosis | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 80 |
Acinus, Atrophy | 1 2 1 1 1 1 3 | 22 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 79 |
Ulcer | | 1 4.0|
Epithelium, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 |
Ulcer | 2 | 2 2.5|
Mucosa, Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 80 |
Degeneration | | 1 1.0|
Myocardium, Degeneration | 1 1 1 2 1 1 2 1 2 2 3 2 2 | 37 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 1 2 3 1 3 2 2 2 | 18 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 6| 5| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 2| 3| 3| 3| 0| 3| 3| 2| 7| 3| 9| 9| 3| 3| 3| 3| 0| 3| | |
| 0| 2| 4| 0| 0| 0| 5| 0| 0| 4| 2| 0| 7| 2| 0| 0| 0| 0| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Mineralization | | 1 2.0|
Vacuolization Cytoplasmic | 1 1 1 1 1 | 20 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + | 75 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst | X X X | 5 |
Pigmentation, Hemosiderin | | 1 2.0|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | | 7 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
C-Cell, Hyperplasia | 3 3 2 3 3 3 2 3 1 2 1 2 1 3 3 1 3 2 | 52 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + | 79 |
Inflammation, Chronic | 2 2 | 5 1.6|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst | X | 1 |
Interstitium, Hyperplasia | | 10 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 80 |
Dilatation | 2 | 1 2.0|
Endometrium, Hyperplasia | | 1 2.0|
Wall, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Anisocytosis | | 1 |
Polychromasia | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + | 78 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 6| 5| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 2| 3| 3| 3| 0| 3| 3| 2| 7| 3| 9| 9| 3| 3| 3| 3| 0| 3| | |
| 0| 2| 4| 0| 0| 0| 5| 0| 0| 4| 2| 0| 7| 2| 0| 0| 0| 0| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 80 |
Congestion | | 1 3.0|
Erythrophagocytosis | | 1 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + + M + + + + | 77 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 79 |
Hyperplasia, Cystic | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 80 |
Abscess | | 1 3.0|
Inflammation, Chronic | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 80 |
Osteopetrosis | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 80 |
Hypothalamus, Compression | X | 6 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 95 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 95 |
Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic | | 2 2.0|
Fat, Mediastinum, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 80 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 80 |
Nephropathy | 2 2 1 1 2 1 1 1 2 1 | 39 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 2| 4| 2| 4| 0| 0| 2| 0| 2| 4| 0| 2| 0| 0| 4| 2| 2| 0| 0| 2| 0| 0| 4| 2|
DAY ON TEST | 7| 7| 5| 7| 5| 9| 9| 7| 9| 7| 5| 9| 7| 9| 9| 5| 7| 7| 0| 9| 7| 9| 9| 5| 7|
| 4| 4| 6| 4| 6| 3| 2| 4| 3| 4| 6| 7| 4| 3| 2| 6| 8| 4| 2| 2| 8| 7| 3| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + |
Fibrosis | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X |
Degeneration, Cystic | |
Degeneration, Fatty | |
Eosinophilic Focus | |
Fatty Change | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | |
Inflammation, Granulomatous | |
Mixed Cell Focus | |
__________________________________________________________________________|
Mesentery | |
Hemorrhage | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | |
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Degeneration | 1 1 |
Myocardium, Degeneration | 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 1 1 1 1 1 2 1 1 2 1 1 1 2 2 1 1 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 2| 4| 2| 4| 0| 0| 2| 0| 2| 4| 0| 2| 0| 0| 4| 2| 2| 0| 0| 2| 0| 0| 4| 2|
DAY ON TEST | 7| 7| 5| 7| 5| 9| 9| 7| 9| 7| 5| 9| 7| 9| 9| 5| 7| 7| 0| 9| 7| 9| 9| 5| 7|
| 4| 4| 6| 4| 6| 3| 2| 4| 3| 4| 6| 7| 4| 3| 2| 6| 8| 4| 2| 2| 8| 7| 3| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + |
Cyst | |
Inflammation, Chronic | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + |
Cyst | X |
Follicle, Cyst | X |
Interstitium, Hyperplasia | 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + |
Dilatation | |
Cervix, Cyst | |
Endometrium, Hyperplasia | |
Wall, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Depletion Lymphoid | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + |
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Abscess | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 2| 4| 2| 4| 0| 0| 2| 0| 2| 4| 0| 2| 0| 0| 4| 2| 2| 0| 0| 2| 0| 0| 4| 2|
DAY ON TEST | 7| 7| 5| 7| 5| 9| 9| 7| 9| 7| 5| 9| 7| 9| 9| 5| 7| 7| 0| 9| 7| 9| 9| 5| 7|
| 4| 4| 6| 4| 6| 3| 2| 4| 3| 4| 6| 7| 4| 3| 2| 6| 8| 4| 2| 2| 8| 7| 3| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
Gliosis | |
Hypothalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Inflammation, Necrotizing | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Synechia | |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Infarct | |
Nephropathy | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 2| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 0| 0| 2| 4| 2| 4| 0| 4| 6| 6| 6| 7| 7|
DAY ON TEST | 7| 7| 5| 9| 5| 5| 5| 5| 7| 5| 9| 5| 9| 9| 7| 5| 7| 5| 9| 5| 6| 7| 5| 0| 2|
| 8| 8| 7| 7| 6| 6| 6| 7| 4| 6| 3| 7| 7| 2| 4| 6| 4| 6| 2| 7| 7| 0| 3| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 8| 8| 8| 8| 8|
300 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X|
Degeneration, Cystic | |
Degeneration, Fatty | |
Eosinophilic Focus | X|
Fatty Change | |
Hepatodiaphragmatic Nodule | X|
Hyperplasia | |
Inflammation, Granulomatous | 1 1 |
Mixed Cell Focus | X |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 2 1 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
Myocardium, Degeneration | 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Vacuolization Cytoplasmic | 1 1 1 1 1 2 2 1 2 1 1 2 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 2| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 0| 0| 2| 4| 2| 4| 0| 4| 6| 6| 6| 7| 7|
DAY ON TEST | 7| 7| 5| 9| 5| 5| 5| 5| 7| 5| 9| 5| 9| 9| 7| 5| 7| 5| 9| 5| 6| 7| 5| 0| 2|
| 8| 8| 7| 7| 6| 6| 6| 7| 4| 6| 3| 7| 7| 2| 4| 6| 4| 6| 2| 7| 7| 0| 3| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 8| 8| 8| 8| 8|
300 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 1 2 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 2 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + +|
Cyst | X X |
Follicle, Cyst | |
Interstitium, Hyperplasia | 1 1 1 1 1 2 2 1 1 1 3 1 1|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + +|
Dilatation | 1 2 2 |
Cervix, Cyst | X |
Endometrium, Hyperplasia | |
Wall, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Abscess | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 2| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 0| 0| 2| 4| 2| 4| 0| 4| 6| 6| 6| 7| 7|
DAY ON TEST | 7| 7| 5| 9| 5| 5| 5| 5| 7| 5| 9| 5| 9| 9| 7| 5| 7| 5| 9| 5| 6| 7| 5| 0| 2|
| 8| 8| 7| 7| 6| 6| 6| 7| 4| 6| 3| 7| 7| 2| 4| 6| 4| 6| 2| 7| 7| 0| 3| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 8| 8| 8| 8| 8|
300 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
Gliosis | |
Hypothalamus, Compression | X|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Necrotizing | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Synechia | |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy | 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 7| 5| 7|
DAY ON TEST | 2| 5| 9| 8| 0| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 9| 2|
| 0| 8| 9| 7| 3| 9| 9| 9| 7| 4| 9| 9| 9| 9| 9| 9| 2| 5| 9| 9| 9| 4| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
300 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + M + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + M + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X|
Degeneration, Cystic | |
Degeneration, Fatty | |
Eosinophilic Focus | X X X |
Fatty Change | 2 |
Hepatodiaphragmatic Nodule | X X X X X |
Hyperplasia | |
Inflammation, Granulomatous | 2|
Mixed Cell Focus | X X |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 1 1 2 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Ulcer | |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Myocardium, Degeneration | 1 2 1 1 3 1 2 2 2 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 1 1 2 3 1 1 1 3 |
Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 7| 5| 7|
DAY ON TEST | 2| 5| 9| 8| 0| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 9| 2|
| 0| 8| 9| 7| 3| 9| 9| 9| 7| 4| 9| 9| 9| 9| 9| 9| 2| 5| 9| 9| 9| 4| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
300 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Inflammation, Chronic | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 4 2 2 3 2 2 3 3 2 2 1 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Follicle, Cyst | |
Interstitium, Hyperplasia | 1 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Cervix, Cyst | |
Endometrium, Hyperplasia | |
Wall, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Inflammation, Granulomatous | 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Cystic | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Subcutaneous Tissue, Edema | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 7| 5| 7|
DAY ON TEST | 2| 5| 9| 8| 0| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 9| 2|
| 0| 8| 9| 7| 3| 9| 9| 9| 7| 4| 9| 9| 9| 9| 9| 9| 2| 5| 9| 9| 9| 4| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
300 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | 2 |
Hypothalamus, Compression | X X X X X X X |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Necrotizing | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Synechia | 3 |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy | 3 1 2 2 1 1 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 5| 9| 5| 2| 9| 1| 2| 4| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| | |
| 9| 0| 1| 9| 9| 8| 2| 9| 6| 9| 9| 9| 9| 9| 3| 9| 9| 9| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
300 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 80 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 80 |
Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + | 77 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 80 |
Basophilic Focus | X X X X X X X X | 23 |
Degeneration, Cystic | 1 | 1 1.0|
Degeneration, Fatty | 1 | 1 1.0|
Eosinophilic Focus | X X X | 7 |
Fatty Change | 2 | 2 2.0|
Hepatodiaphragmatic Nodule | | 7 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Granulomatous | | 3 1.3|
Mixed Cell Focus | X | 4 |
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Hemorrhage | 2 | 1 2.0|
Fat, Necrosis | 2 | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic | | 1 1.0|
Acinus, Atrophy | 1 2 1 1 1 2 2 | 14 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst Epithelial Inclusion | X | 1 |
Ulcer | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 |
Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 80 |
Degeneration | | 3 1.0|
Myocardium, Degeneration | 1 1 2 1 2 1 2 1 2 1 2 1 | 33 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 5| 9| 5| 2| 9| 1| 2| 4| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| | |
| 9| 0| 1| 9| 9| 8| 2| 9| 6| 9| 9| 9| 9| 9| 3| 9| 9| 9| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
300 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 2 2 2 1 3 2 2 2 2 | 22 1.9|
Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1 1 | 66 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + M + + + M + + | 73 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst | X X X | 5 |
Inflammation, Chronic | 2 | 1 2.0|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
C-Cell, Hyperplasia | 2 3 2 3 3 2 3 2 2 2 1 | 39 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + | 79 |
Inflammation, Chronic | 2 1 | 3 2.0|
Inflammation, Chronic Active | | 4 1.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst | X | 5 |
Follicle, Cyst | | 1 |
Interstitium, Hyperplasia | 1 1 1 1 1 | 44 1.2|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 80 |
Dilatation | 2 | 5 1.8|
Cervix, Cyst | | 1 |
Endometrium, Hyperplasia | 2 | 1 2.0|
Wall, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 80 |
Depletion Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 5| 9| 5| 2| 9| 1| 2| 4| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| | |
| 9| 0| 1| 9| 9| 8| 2| 9| 6| 9| 9| 9| 9| 9| 3| 9| 9| 9| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
300 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + + + + | 78 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 79 |
Hyperplasia, Cystic | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 80 |
Abscess | 4 | 1 4.0|
Subcutaneous Tissue, Edema | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 80 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 80 |
Gliosis | | 1 2.0|
Hypothalamus, Compression | X X X X | 12 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 94 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 94 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 80 |
Hemorrhage | | 1 3.0|
Inflammation, Necrotizing | | 1 2.0|
Inflammation, Suppurative | 1 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 80 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 2 |
Synechia | | 1 3.0|
Lens, Cataract | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 80 |
Infarct | 2 | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 1 | 34 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 5| 9| 5| 2| 9| 1| 2| 4| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| | |
| 9| 0| 1| 9| 9| 8| 2| 9| 6| 9| 9| 9| 9| 9| 3| 9| 9| 9| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
300 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 4| 2| 4| 4| 2| 0| 4| 0| 0| 2| 0| 0| 0| 2| 4| 0| 4| 4| 0| 2| 0| 4| 2| 0|
DAY ON TEST | 7| 5| 7| 5| 5| 7| 9| 5| 9| 9| 7| 9| 9| 9| 7| 5| 9| 5| 5| 9| 7| 9| 5| 7| 9|
| 4| 7| 8| 6| 6| 4| 7| 6| 3| 7| 4| 3| 3| 2| 4| 6| 7| 6| 7| 2| 8| 3| 7| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
23 STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + |
Basophilic Focus | |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + |
Myocardium, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 2 2 1 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 2 2 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 4| 2| 4| 4| 2| 0| 4| 0| 0| 2| 0| 0| 0| 2| 4| 0| 4| 4| 0| 2| 0| 4| 2| 0|
DAY ON TEST | 7| 5| 7| 5| 5| 7| 9| 5| 9| 9| 7| 9| 9| 9| 7| 5| 9| 5| 5| 9| 7| 9| 5| 7| 9|
| 4| 7| 8| 6| 6| 4| 7| 6| 3| 7| 4| 3| 3| 2| 4| 6| 7| 6| 7| 2| 8| 3| 7| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
23 STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitium, Hyperplasia | 1 4 1 3 2 2 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + |
Dilatation | |
__________________________________________________________________________|
Vagina | |
Inflammation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + |
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + |
Nephropathy | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 1| 1| 1| 1| 1|
DAY ON TEST | 5| 9| 2| 9| 5| 5| 5| 9| 7| 5| 7| 7| 5| 9| 7| 7| 7| 7| 7| 9| 6| 6| 6| 6| 6|
| 6| 2| 2| 2| 6| 6| 7| 2| 8| 6| 4| 4| 7| 7| 8| 4| 4| 4| 4| 3| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 9| 9| 9| 9|
600 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 3| 3| 3| 3| 3|
23 STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + |
Basophilic Focus | X |
Hepatodiaphragmatic Nodule | 3 X X |
Inflammation, Granulomatous | 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + |
Myocardium, Degeneration | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | M + + + + + + + + + + + + + + |
Hyperplasia | 2 1 |
Vacuolization Cytoplasmic | 2 1 2 2 |
__________________________________________________________________________|
Adrenal Medulla | M + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + M M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 1| 1| 1| 1| 1|
DAY ON TEST | 5| 9| 2| 9| 5| 5| 5| 9| 7| 5| 7| 7| 5| 9| 7| 7| 7| 7| 7| 9| 6| 6| 6| 6| 6|
| 6| 2| 2| 2| 6| 6| 7| 2| 8| 6| 4| 4| 7| 7| 8| 4| 4| 4| 4| 3| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 9| 9| 9| 9|
600 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 3| 3| 3| 3| 3|
23 STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitium, Hyperplasia | 2 3 2 1 1 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + |
Dilatation | 1 |
__________________________________________________________________________|
Vagina | + |
Inflammation | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + |
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
Inflammation, Chronic | 3 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + M + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + |
Nephropathy | 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
600 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
23 STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Intestine Large, Colon | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Liver | |
Basophilic Focus | |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | |
__________________________________________________________________________|
Salivary Glands | |
__________________________________________________________________________|
Stomach, Forestomach | |
__________________________________________________________________________|
Stomach, Glandular | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
Myocardium, Degeneration | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | |
Hyperplasia | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
600 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
23 STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitium, Hyperplasia | |
__________________________________________________________________________|
Uterus | |
Dilatation | |
__________________________________________________________________________|
Vagina | |
Inflammation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
__________________________________________________________________________|
Spleen | |
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | |
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
__________________________________________________________________________|
Nose | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | |
Nephropathy | |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
600 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
23 STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 30 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 30 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 30 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 30 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 30 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 30 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 30 |
__________________________________________________________________________|____________|
Liver | | 30 |
Basophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | | 4 3.0|
Inflammation, Granulomatous | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | | 30 |
__________________________________________________________________________|____________|
Salivary Glands | | 30 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 30 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 30 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 30 |
Myocardium, Degeneration | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 29 |
Hyperplasia | | 3 1.3|
Vacuolization Cytoplasmic | | 9 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | | 29 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 30 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 26 |
__________________________________________________________________________|____________|
Pituitary Gland | | 30 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 30 |
C-Cell, Hyperplasia | | 8 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
600 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
23 STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 30 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 2 1.0|
__________________________________________________________________________|____________|
Ovary | | 30 |
Interstitium, Hyperplasia | | 14 2.1|
__________________________________________________________________________|____________|
Uterus | | 30 |
Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 30 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 30 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 30 |
__________________________________________________________________________|____________|
Spleen | | 30 |
__________________________________________________________________________|____________|
Thymus | | 30 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 30 |
Hyperplasia, Cystic | | 1 2.0|
__________________________________________________________________________|____________|
Skin | | 30 |
Inflammation, Chronic | | 1 3.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 29 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 30 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 45 |
__________________________________________________________________________|____________|
Spinal Cord | | 45 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 30 |
__________________________________________________________________________|____________|
Nose | | 30 |
__________________________________________________________________________|____________|
Trachea | | 30 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
600 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
23 STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 30 |
Nephropathy | | 6 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 30 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 2| 0| 4| 4| 0| 4| 2| 0| 4| 4| 4| 0| 4| 2| 2| 2| 2| 4| 0| 0| 0| 2| 2| 0|
DAY ON TEST | 7| 7| 9| 5| 5| 9| 5| 7| 8| 5| 5| 5| 9| 5| 7| 7| 7| 7| 5| 9| 9| 9| 7| 7| 9|
| 3| 3| 2| 5| 5| 6| 7| 8| 7| 5| 5| 7| 3| 5| 8| 3| 3| 8| 5| 6| 2| 3| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + |
Venule, Parasite Metazoan | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + |
Basophilic Focus | X |
Clear Cell Focus | |
Degeneration, Cystic | 1 |
Eosinophilic Focus | X X |
Fatty Change | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | |
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 1 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 2 |
Acinus, Atrophy | 2 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + |
Degeneration | 2 1 2 2 |
Atrium, Dilatation | |
Atrium, Thrombosis | |
Intima, Hyperplasia | |
Myocardium, Degeneration | 1 1 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 2| 0| 4| 4| 0| 4| 2| 0| 4| 4| 4| 0| 4| 2| 2| 2| 2| 4| 0| 0| 0| 2| 2| 0|
DAY ON TEST | 7| 7| 9| 5| 5| 9| 5| 7| 8| 5| 5| 5| 9| 5| 7| 7| 7| 7| 5| 9| 9| 9| 7| 7| 9|
| 3| 3| 2| 5| 5| 6| 7| 8| 7| 5| 5| 7| 3| 5| 8| 3| 3| 8| 5| 6| 2| 3| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + |
Cyst | |
Pars Distalis, Hyperplasia | 2 |
Pars Distalis, Mineralization | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 2 2 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + |
Hyperplasia | |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 1 2 2 1 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + |
Atrophy | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + |
Congestion | |
Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + |
Dermis, Mineralization | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 2| 0| 4| 4| 0| 4| 2| 0| 4| 4| 4| 0| 4| 2| 2| 2| 2| 4| 0| 0| 0| 2| 2| 0|
DAY ON TEST | 7| 7| 9| 5| 5| 9| 5| 7| 8| 5| 5| 5| 9| 5| 7| 7| 7| 7| 5| 9| 9| 9| 7| 7| 9|
| 3| 3| 2| 5| 5| 6| 7| 8| 7| 5| 5| 7| 3| 5| 8| 3| 3| 8| 5| 6| 2| 3| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + |
Hypothalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | 3 |
Nares, Hemorrhage | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Inflammation, Chronic | |
Lens, Cataract | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + |
Nephropathy | 1 1 1 2 1 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 4| 4| 2| 0| 4| 0| 0| 0| 4| 0| 0| 4| 2| 2| 2| 0| 4| 2| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 9| 5| 5| 7| 9| 5| 9| 9| 9| 5| 9| 9| 5| 7| 7| 7| 9| 5| 7| 5| 7| 3| 3| 3| 3|
| 3| 5| 7| 3| 6| 7| 3| 2| 3| 7| 6| 2| 5| 8| 3| 8| 2| 5| 3| 5| 8| 1| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 4| 4| 4|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +|
Venule, Parasite Metazoan | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + M|
Basophilic Focus | |
Clear Cell Focus | |
Degeneration, Cystic | 1 |
Eosinophilic Focus | X |
Fatty Change | |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic | 2 |
Inflammation, Granulomatous | |
Mixed Cell Focus | |
Necrosis | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 1 1 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 |
Atrium, Dilatation | |
Atrium, Thrombosis | X |
Intima, Hyperplasia | |
Myocardium, Degeneration | 1 2 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + M|
Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 4| 4| 2| 0| 4| 0| 0| 0| 4| 0| 0| 4| 2| 2| 2| 0| 4| 2| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 9| 5| 5| 7| 9| 5| 9| 9| 9| 5| 9| 9| 5| 7| 7| 7| 9| 5| 7| 5| 7| 3| 3| 3| 3|
| 3| 5| 7| 3| 6| 7| 3| 2| 3| 7| 6| 2| 5| 8| 3| 8| 2| 5| 3| 5| 8| 1| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 4| 4| 4|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + M|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | |
Pars Distalis, Mineralization | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + M + +|
Hyperplasia | |
Inflammation, Chronic | 1 1 2|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + M|
Congestion | |
Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Dermis, Mineralization | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 4| 4| 2| 0| 4| 0| 0| 0| 4| 0| 0| 4| 2| 2| 2| 0| 4| 2| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 9| 5| 5| 7| 9| 5| 9| 9| 9| 5| 9| 9| 5| 7| 7| 7| 9| 5| 7| 5| 7| 3| 3| 3| 3|
| 3| 5| 7| 3| 6| 7| 3| 2| 3| 7| 6| 2| 5| 8| 3| 8| 2| 5| 3| 5| 8| 1| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 4| 4| 4|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Nares, Hemorrhage | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Inflammation, Chronic | |
Lens, Cataract | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 2 3 2 2 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 4| 3| 2| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 0| 3|
| 2| 2| 7| 2| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 1| 2| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Venule, Parasite Metazoan | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Degeneration, Cystic | 1 1 1 2 |
Eosinophilic Focus | X X X X X X|
Fatty Change | 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | |
Inflammation, Granulomatous | |
Mixed Cell Focus | |
Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 1 1 2 2 1 1 2 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Atrium, Dilatation | 4 |
Atrium, Thrombosis | X |
Intima, Hyperplasia | 3 |
Myocardium, Degeneration | 2 2 2 3 3 3 2 2 2 2 2 3 2 3 1 1 2 3 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 4| 3| 2| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 0| 3|
| 2| 2| 7| 2| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 1| 2| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 3 2 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Pars Distalis, Hyperplasia | 1 1 |
Pars Distalis, Mineralization | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 2 2 1 3 2 2 2 3 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic | 3 2 2 2 2 3 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis | 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 4| 3| 2| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 0| 3|
| 2| 2| 7| 2| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 1| 2| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | X |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Nares, Hemorrhage | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Inflammation, Chronic | 3 |
Lens, Cataract | 4 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 1 3 2 1 3 1 1 1 3 1 2 2 2 2 4 2 1 1 2 2 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 5| | |
DAY ON TEST | 2| 2| 8| 3| 3| 3| 4| 3| 3| 3| 0| 8| 8| 3| 3| 3| 7| 3| 0| 5| | |
| 2| 5| 6| 2| 2| 2| 7| 2| 2| 2| 0| 3| 0| 2| 2| 2| 3| 2| 2| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + | 79 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 80 |
Parasite Metazoan | X X X | 7 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + | 78 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + | 78 |
Venule, Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 79 |
Basophilic Focus | X X | 3 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | 1 | 7 1.1|
Eosinophilic Focus | | 9 |
Fatty Change | | 1 2.0|
Hepatodiaphragmatic Nodule | X X X | 5 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Granulomatous | | 1 1.0|
Mixed Cell Focus | X | 1 |
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Inflammation, Chronic | | 1 1.0|
Fat, Necrosis | 2 | 4 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic | | 2 1.5|
Acinus, Atrophy | 2 3 1 1 1 2 2 2 | 26 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 80 |
Ulcer | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 |
Ulcer | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 80 |
Degeneration | | 7 1.4|
Atrium, Dilatation | | 1 4.0|
Atrium, Thrombosis | | 2 |
Intima, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 5| | |
DAY ON TEST | 2| 2| 8| 3| 3| 3| 4| 3| 3| 3| 0| 8| 8| 3| 3| 3| 7| 3| 0| 5| | |
| 2| 5| 6| 2| 2| 2| 7| 2| 2| 2| 0| 3| 0| 2| 2| 2| 3| 2| 2| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Myocardium, Degeneration | 1 3 2 3 2 1 2 2 1 2 1 2 3 | 48 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 79 |
Hyperplasia | 2 3 2 2 1 | 9 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 79 |
Hyperplasia | 1 2 | 11 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + M M + + M + M + + + + + + + | 73 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst | | 1 |
Pars Distalis, Hyperplasia | | 3 1.3|
Pars Distalis, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
C-Cell, Hyperplasia | 3 2 1 2 3 3 2 2 2 2 | 32 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 79 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 2 | 14 1.8|
Inflammation, Chronic Active | | 7 1.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic Active | | 2 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 80 |
Atrophy | | 1 4.0|
Interstitial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 5| | |
DAY ON TEST | 2| 2| 8| 3| 3| 3| 4| 3| 3| 3| 0| 8| 8| 3| 3| 3| 7| 3| 0| 5| | |
| 2| 5| 6| 2| 2| 2| 7| 2| 2| 2| 0| 3| 0| 2| 2| 2| 3| 2| 2| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Congestion | | 1 3.0|
Fibrosis | | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + | 79 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + + + M + + + + + + + | 75 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 80 |
Dermis, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 80 |
Hypothalamus, Compression | | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 95 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 95 |
Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Suppurative | 2 | 2 2.5|
Nares, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 80 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 8 |
Inflammation, Chronic | | 1 3.0|
Lens, Cataract | 4 | 4 3.5|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 80 |
Nephropathy | 1 1 1 2 1 2 1 2 1 1 3 1 2 1 2 1 2 3 | 62 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 0| 0| 2| 0| 4| 2| 4| 4| 0| 4| 4| 2| 4| 2| 2| 0| 2| 2| 0| 0| 0| 2| 4| 0|
DAY ON TEST | 9| 9| 9| 7| 9| 5| 7| 5| 5| 9| 5| 5| 7| 5| 7| 7| 9| 7| 7| 9| 9| 9| 7| 5| 9|
| 3| 6| 6| 3| 2| 5| 3| 7| 5| 2| 5| 7| 8| 7| 8| 3| 3| 8| 3| 6| 3| 3| 3| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
75 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Degeneration, Cystic | |
Eosinophilic Focus | |
Fatty Change | |
Hepatodiaphragmatic Nodule | |
Hyperplasia | |
Mixed Cell Focus | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 1 1 1 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 1 1 |
Artery, Inflammation, Chronic | |
Atrium, Thrombosis | |
Myocardium, Degeneration | 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 0| 0| 2| 0| 4| 2| 4| 4| 0| 4| 4| 2| 4| 2| 2| 0| 2| 2| 0| 0| 0| 2| 4| 0|
DAY ON TEST | 9| 9| 9| 7| 9| 5| 7| 5| 5| 9| 5| 5| 7| 5| 7| 7| 9| 7| 7| 9| 9| 9| 7| 5| 9|
| 3| 6| 6| 3| 2| 5| 3| 7| 5| 2| 5| 7| 8| 7| 8| 3| 3| 8| 3| 6| 3| 3| 3| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
75 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Degeneration, Focal | |
Pars Distalis, Hyperplasia | |
Pars Distalis, Inflammation, Chronic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 |
Follicle, Dilatation | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | 1 1 1 1 1 1 |
Inflammation, Chronic Active | 3 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic Active | 1 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Infarct | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 0| 0| 2| 0| 4| 2| 4| 4| 0| 4| 4| 2| 4| 2| 2| 0| 2| 2| 0| 0| 0| 2| 4| 0|
DAY ON TEST | 9| 9| 9| 7| 9| 5| 7| 5| 5| 9| 5| 5| 7| 5| 7| 7| 9| 7| 7| 9| 9| 9| 7| 5| 9|
| 3| 6| 6| 3| 2| 5| 3| 7| 5| 2| 5| 7| 8| 7| 8| 3| 3| 8| 3| 6| 3| 3| 3| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
75 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Infarct | |
Hypothalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy | 1 2 1 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + M + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 0| 2| 2| 4| 2| 0| 4| 0| 0| 2| 4| 2| 4| 4| 4| 0| 2| 4| 4| 5| 5| 6| 7| 6|
DAY ON TEST | 7| 9| 7| 7| 5| 7| 9| 5| 9| 9| 7| 5| 7| 5| 5| 5| 9| 7| 5| 5| 9| 3| 1| 3| 9|
| 8| 3| 8| 3| 5| 3| 6| 5| 6| 2| 3| 7| 3| 5| 5| 5| 2| 3| 5| 7| 0| 7| 4| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 5| 5| 5| 5|
75 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Degeneration, Cystic | |
Eosinophilic Focus | X |
Fatty Change | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | |
Mixed Cell Focus | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Acinus, Atrophy | 1 1 2 1 2|
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 2 1 1 |
Artery, Inflammation, Chronic | |
Atrium, Thrombosis | |
Myocardium, Degeneration | 2 2 1 1 1 1 1 1 1 2 3 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 0| 2| 2| 4| 2| 0| 4| 0| 0| 2| 4| 2| 4| 4| 4| 0| 2| 4| 4| 5| 5| 6| 7| 6|
DAY ON TEST | 7| 9| 7| 7| 5| 7| 9| 5| 9| 9| 7| 5| 7| 5| 5| 5| 9| 7| 5| 5| 9| 3| 1| 3| 9|
| 8| 3| 8| 3| 5| 3| 6| 5| 6| 2| 3| 7| 3| 5| 5| 5| 2| 3| 5| 7| 0| 7| 4| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 5| 5| 5| 5|
75 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Degeneration, Focal | |
Pars Distalis, Hyperplasia | 1 1 |
Pars Distalis, Inflammation, Chronic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2|
Follicle, Dilatation | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic | 1 1 1 3 |
Inflammation, Chronic Active | 2 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Infarct | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 0| 2| 2| 4| 2| 0| 4| 0| 0| 2| 4| 2| 4| 4| 4| 0| 2| 4| 4| 5| 5| 6| 7| 6|
DAY ON TEST | 7| 9| 7| 7| 5| 7| 9| 5| 9| 9| 7| 5| 7| 5| 5| 5| 9| 7| 5| 5| 9| 3| 1| 3| 9|
| 8| 3| 8| 3| 5| 3| 6| 5| 6| 2| 3| 7| 3| 5| 5| 5| 2| 3| 5| 7| 0| 7| 4| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 5| 5| 5| 5|
75 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + M + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + M + + + + + +|
Hydrocephalus | |
Infarct | |
Hypothalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Nephropathy | 1 1 2 1 2 1 1 2 1 1 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 2| 0| 3| 3| 3| 3|
| 0| 6| 2| 5| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 0| 5| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
75 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | 1 |
Eosinophilic Focus | X X |
Fatty Change | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | 3 |
Mixed Cell Focus | X |
__________________________________________________________________________|
Mesentery | + + + +|
Inflammation, Chronic | |
Fat, Necrosis | 3 2 3 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 1 1 2 2 1 2 1 1 2 1 2 1 1 2 1|
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Artery, Inflammation, Chronic | 3 |
Atrium, Thrombosis | |
Myocardium, Degeneration | 2 2 1 3 2 3 3 3 3 2 2 3 1 2 1 2 3 2 3 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 2 2 2 2 2 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 2| 0| 3| 3| 3| 3|
| 0| 6| 2| 5| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 0| 5| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
75 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + M M + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Pars Distalis, Degeneration, Focal | 2 |
Pars Distalis, Hyperplasia | 1 1 1 |
Pars Distalis, Inflammation, Chronic | 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 4 3 2 3 2 3 2 2 3 2 2 2 2 3 2 2 2 3|
Follicle, Dilatation | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | 3 3 1 2 2 2 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
Infarct | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 2| 0| 3| 3| 3| 3|
| 0| 6| 2| 5| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 0| 5| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
75 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic | 3 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 |
Infarct | |
Hypothalamus, Compression | X |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy | 3 1 1 1 1 4 1 2 2 2 2 2 2 2 2 1 3 1 2 2 1 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 2| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 0| 3| 3| 4| 3| 5| 6| 3| 1| 1| 9| 9| 3| 3| 3| 3| 3| 3| 5| 3| | |
| 1| 1| 1| 8| 1| 5| 3| 1| 1| 4| 9| 8| 1| 1| 1| 1| 1| 1| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
75 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + M + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + M + + + + + + + + + + + + + | 79 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + M + + + + + + + + | 79 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + | 79 |
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 80 |
Basophilic Focus | X X X | 8 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | | 1 1.0|
Eosinophilic Focus | X | 4 |
Fatty Change | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X X | 5 |
Hyperplasia | 2 | 2 2.5|
Mixed Cell Focus | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + | 8 |
Inflammation, Chronic | 2 | 1 2.0|
Fat, Necrosis | 3 2 | 7 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic | | 1 1.0|
Acinus, Atrophy | 3 1 1 1 2 | 28 1.4|
Acinus, Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 |
Ulcer | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 80 |
Degeneration | | 10 1.1|
Artery, Inflammation, Chronic | | 1 3.0|
Atrium, Thrombosis | X | 1 |
Myocardium, Degeneration | 1 2 3 2 2 1 2 1 1 1 2 2 2 2 1 2 | 55 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 2| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 0| 3| 3| 4| 3| 5| 6| 3| 1| 1| 9| 9| 3| 3| 3| 3| 3| 3| 5| 3| | |
| 1| 1| 1| 8| 1| 5| 3| 1| 1| 4| 9| 8| 1| 1| 1| 1| 1| 1| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
75 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 79 |
Hyperplasia | 2 1 1 1 2 | 17 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | | 4 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + | 72 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst | | 2 |
Pars Distalis, Degeneration, Focal | | 1 2.0|
Pars Distalis, Hyperplasia | 2 | 6 1.2|
Pars Distalis, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
C-Cell, Hyperplasia | 3 2 2 2 2 2 2 3 3 3 3 2 | 42 2.3|
Follicle, Dilatation | 3 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + M | 79 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 2 1 2 2 2 2 | 23 1.7|
Inflammation, Chronic Active | | 5 1.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 80 |
Abscess | 4 | 1 4.0|
Inflammation, Chronic Active | | 4 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 80 |
Seminiferous Tubule, Atrophy | | 2 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + | 79 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 2| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 0| 3| 3| 4| 3| 5| 6| 3| 1| 1| 9| 9| 3| 3| 3| 3| 3| 3| 5| 3| | |
| 1| 1| 1| 8| 1| 5| 3| 1| 1| 4| 9| 8| 1| 1| 1| 1| 1| 1| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
75 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 80 |
Fibrosis | | 2 3.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infarct | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + M M M | 77 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 75 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 79 |
Abscess | 3 | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 79 |
Hydrocephalus | | 1 3.0|
Infarct | 3 | 1 3.0|
Hypothalamus, Compression | | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 95 |
Axon, Degeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 95 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic | 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Suppurative | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + M + + + + + + + + + | 79 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
Lens, Cataract | 2 | 3 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 2| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 0| 3| 3| 4| 3| 5| 6| 3| 1| 1| 9| 9| 3| 3| 3| 3| 3| 3| 5| 3| | |
| 1| 1| 1| 8| 1| 5| 3| 1| 1| 4| 9| 8| 1| 1| 1| 1| 1| 1| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
75 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 80 |
Infarct | | 1 2.0|
Nephropathy | 2 1 1 2 1 1 3 2 2 3 1 2 3 3 2 1 4 1 3 | 61 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 79 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 0| 2| 2| 4| 4| 4| 0| 4| 2| 0| 0| 2| 4| 4| 0| 4| 0| 0| 2| 0| 2| 2| 0| 0|
DAY ON TEST | 7| 9| 7| 7| 5| 5| 5| 9| 5| 7| 9| 9| 7| 5| 5| 9| 5| 9| 9| 7| 9| 7| 7| 9| 9|
| 3| 3| 8| 3| 7| 5| 5| 2| 5| 3| 6| 6| 8| 7| 7| 3| 5| 6| 3| 8| 3| 3| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Degeneration, Cystic | |
Eosinophilic Focus | |
Fatty Change | |
Hepatodiaphragmatic Nodule | |
Hyperplasia | |
Mixed Cell Focus | |
Necrosis | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 2 1 |
Atrium, Thrombosis | |
Myocardium, Degeneration | 1 2 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 0| 2| 2| 4| 4| 4| 0| 4| 2| 0| 0| 2| 4| 4| 0| 4| 0| 0| 2| 0| 2| 2| 0| 0|
DAY ON TEST | 7| 9| 7| 7| 5| 5| 5| 9| 5| 7| 9| 9| 7| 5| 5| 9| 5| 9| 9| 7| 9| 7| 7| 9| 9|
| 3| 3| 8| 3| 7| 5| 5| 2| 5| 3| 6| 6| 8| 7| 7| 3| 5| 6| 3| 8| 3| 3| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + +|
Hypospermia | X|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + +|
Hypospermia | X|
Seminiferous Tubule, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 2| 0| 2| 2| 4| 4| 4| 0| 4| 2| 0| 0| 2| 4| 4| 0| 4| 0| 0| 2| 0| 2| 2| 0| 0|
DAY ON TEST | 7| 9| 7| 7| 5| 5| 5| 9| 5| 7| 9| 9| 7| 5| 5| 9| 5| 9| 9| 7| 9| 7| 7| 9| 9|
| 3| 3| 8| 3| 7| 5| 5| 2| 5| 3| 6| 6| 8| 7| 7| 3| 5| 6| 3| 8| 3| 3| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Erythrophagocytosis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Ulcer | |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 4| 2| 4| 4| 0| 2| 2| 4| 4| 4| 4| 2| 0| 0| 0| 2| 2| 0| 4| 2| 7| 5| 7| 6| 7|
DAY ON TEST | 5| 7| 5| 5| 9| 7| 7| 5| 5| 5| 5| 7| 9| 9| 9| 7| 7| 9| 5| 7| 0| 5| 2| 2| 2|
| 5| 8| 5| 7| 2| 8| 3| 5| 5| 5| 7| 3| 6| 2| 3| 3| 3| 6| 5| 3| 1| 3| 9| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5|
150 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Degeneration, Cystic | 1 |
Eosinophilic Focus | |
Fatty Change | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | |
Mixed Cell Focus | |
Necrosis | 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 |
Acinus, Atrophy | 1 1 2 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 2 1 |
Atrium, Thrombosis | X |
Myocardium, Degeneration | 3 1 1 1 2 1 2 3 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 4| 2| 4| 4| 0| 2| 2| 4| 4| 4| 4| 2| 0| 0| 0| 2| 2| 0| 4| 2| 7| 5| 7| 6| 7|
DAY ON TEST | 5| 7| 5| 5| 9| 7| 7| 5| 5| 5| 5| 7| 9| 9| 9| 7| 7| 9| 5| 7| 0| 5| 2| 2| 2|
| 5| 8| 5| 7| 2| 8| 3| 5| 5| 5| 7| 3| 6| 2| 3| 3| 3| 6| 5| 3| 1| 3| 9| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5|
150 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 3 3 2 1 3 3 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
Hypospermia | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + M + + + + M + + + +|
Inflammation, Chronic | 1 1 3|
Inflammation, Chronic Active | 1 2 1 1 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Hypospermia | |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 4 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 4| 2| 4| 4| 0| 2| 2| 4| 4| 4| 4| 2| 0| 0| 0| 2| 2| 0| 4| 2| 7| 5| 7| 6| 7|
DAY ON TEST | 5| 7| 5| 5| 9| 7| 7| 5| 5| 5| 5| 7| 9| 9| 9| 7| 7| 9| 5| 7| 0| 5| 2| 2| 2|
| 5| 8| 5| 7| 2| 8| 3| 5| 5| 5| 7| 3| 6| 2| 3| 3| 3| 6| 5| 3| 1| 3| 9| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5|
150 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Ulcer | |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 2 1 1 1 1 1 2 2 1 3 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 1| 2| 3|
| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 0| 4| 0| 0| 0| 0| 9| 0| 0| 0| 8| 2| 4| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
150 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | 1 |
Eosinophilic Focus | X X X X |
Fatty Change | 3 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | 2 4|
Mixed Cell Focus | |
Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 2 2 2 1 1 2 2 1 2 2 2 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Atrium, Thrombosis | X |
Myocardium, Degeneration | 1 2 3 2 4 2 3 1 1 2 2 2 3 2 1 2 1 1 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 1| 2| 3|
| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 0| 4| 0| 0| 0| 0| 9| 0| 0| 0| 8| 2| 4| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
150 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 4 4 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 1 2 2 2 1 2 1 2 2 2 2 3 2 2 2 2 2 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 2 3 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + M + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 1| 2| 3|
| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 0| 4| 0| 0| 0| 0| 9| 0| 0| 0| 8| 2| 4| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
150 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | X X |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Ulcer | |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 2 2 2 1 2 2 1 1 1 1 1 2 2 3 2 2 2 2 1 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 6| 8| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| | |
| 0| 0| 0| 0| 0| 0| 1| 9| 2| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
150 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + | 79 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + | 78 |
Parasite Metazoan | X X X X | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + | 78 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + | 78 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 79 |
Basophilic Focus | X | 6 |
Clear Cell Focus | X | 2 |
Degeneration, Cystic | 2 3 1 1 1 | 7 1.4|
Eosinophilic Focus | X X X | 7 |
Fatty Change | | 1 3.0|
Hepatodiaphragmatic Nodule | X X X | 5 |
Hyperplasia | | 2 3.0|
Mixed Cell Focus | X | 1 |
Necrosis | | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fat, Necrosis | 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + + + + + + | 79 |
Inflammation, Chronic | | 2 1.5|
Acinus, Atrophy | 1 1 1 2 2 3 1 2 | 24 1.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst Epithelial Inclusion | | 1 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 80 |
Ulcer | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 80 |
Degeneration | | 8 1.3|
Atrium, Thrombosis | | 2 |
Myocardium, Degeneration | 2 1 3 3 2 2 2 4 3 2 3 2 2 2 2 2 | 54 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 6| 8| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| | |
| 0| 0| 0| 0| 0| 0| 1| 9| 2| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
150 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 3 4 2 1 | 10 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 80 |
Hyperplasia | 3 2 2 2 1 3 | 6 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + | 76 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
Pars Distalis, Hyperplasia | 2 | 10 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 80 |
C-Cell, Hyperplasia | 3 2 2 2 2 2 2 3 2 2 3 2 2 2 2 1 | 48 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 80 |
Hypospermia | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 77 |
Inflammation, Chronic | 3 2 3 | 14 2.1|
Inflammation, Chronic Active | | 8 1.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 4 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 80 |
Hypospermia | | 1 |
Seminiferous Tubule, Atrophy | | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 80 |
Fibrosis | 2 2 | 2 2.0|
Hematopoietic Cell Proliferation | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 6| 8| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| | |
| 0| 0| 0| 0| 0| 0| 1| 9| 2| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
150 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + | 77 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + M + + + + M + + + + + + | 75 |
Hyperplasia, Cystic | | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 80 |
Cyst Epithelial Inclusion | X | 1 |
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 80 |
Hypothalamus, Compression | | 2 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 93 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 95 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 80 |
Erythrophagocytosis | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 80 |
Inflammation, Suppurative | 2 | 4 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 79 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Pinna, Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Eye | + | 1 |
Phthisis Bulbi | X | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 80 |
Nephropathy | 2 2 2 2 1 2 4 2 3 1 1 2 3 1 2 1 1 | 60 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 2| 4| 0| 2| 4| 2| 4| 4| 2| 2| 2| 0| 4| 0| 0| 2| 2| 4| 4| 2| 0| 4| 2| 2|
DAY ON TEST | 9| 7| 5| 9| 7| 5| 7| 5| 5| 7| 7| 7| 9| 5| 9| 9| 7| 7| 5| 5| 7| 9| 5| 7| 7|
| 3| 3| 7| 3| 3| 5| 3| 5| 7| 3| 3| 8| 2| 5| 6| 6| 3| 3| 5| 5| 3| 3| 5| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
300 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | |
Degeneration, Cystic | |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation, Chronic | |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 |
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
Ulcer | |
__________________________________________________________________________|
Tongue | |
Mucosa, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Tooth | |
Cyst | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Degeneration | 1 1 1 1 1 2 |
Atrium, Dilatation | |
Myocardium, Degeneration | 1 3 3 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 2| 4| 0| 2| 4| 2| 4| 4| 2| 2| 2| 0| 4| 0| 0| 2| 2| 4| 4| 2| 0| 4| 2| 2|
DAY ON TEST | 9| 7| 5| 9| 7| 5| 7| 5| 5| 7| 7| 7| 9| 5| 9| 9| 7| 7| 5| 5| 7| 9| 5| 7| 7|
| 3| 3| 7| 3| 3| 5| 3| 5| 7| 3| 3| 8| 2| 5| 6| 6| 3| 3| 5| 5| 3| 3| 5| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
300 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + |
Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 2 1 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Fibrosis | |
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Abscess | 3 |
Acanthosis | |
Hyperkeratosis | |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 2| 4| 0| 2| 4| 2| 4| 4| 2| 2| 2| 0| 4| 0| 0| 2| 2| 4| 4| 2| 0| 4| 2| 2|
DAY ON TEST | 9| 7| 5| 9| 7| 5| 7| 5| 5| 7| 7| 7| 9| 5| 9| 9| 7| 7| 5| 5| 7| 9| 5| 7| 7|
| 3| 3| 7| 3| 3| 5| 3| 5| 7| 3| 3| 8| 2| 5| 6| 6| 3| 3| 5| 5| 3| 3| 5| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
300 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Hypothalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nerve, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Lens, Cataract, Focal | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Hydronephrosis | |
Nephropathy | 1 1 2 2 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + |
Mucosa, Ulcer | |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 0| 2| 4| 2| 0| 0| 0| 0| 0| 4| 0| 0| 4| 4| 2| 2| 4| 4| 4| 5| 7| 7| 7| 6|
DAY ON TEST | 9| 9| 7| 5| 7| 9| 9| 9| 9| 9| 5| 9| 9| 5| 5| 7| 7| 5| 5| 5| 8| 2| 2| 2| 9|
| 2| 3| 8| 5| 8| 6| 6| 2| 3| 6| 7| 2| 2| 7| 7| 8| 3| 5| 5| 5| 9| 9| 9| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 6| 6| 6| 6|
300 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | |
Degeneration, Cystic | 2 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | |
Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Artery, Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
Ulcer | 2|
__________________________________________________________________________|
Tongue | |
Mucosa, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Tooth | + |
Cyst | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Degeneration | |
Atrium, Dilatation | |
Myocardium, Degeneration | 1 2 1 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 0| 2| 4| 2| 0| 0| 0| 0| 0| 4| 0| 0| 4| 4| 2| 2| 4| 4| 4| 5| 7| 7| 7| 6|
DAY ON TEST | 9| 9| 7| 5| 7| 9| 9| 9| 9| 9| 5| 9| 9| 5| 5| 7| 7| 5| 5| 5| 8| 2| 2| 2| 9|
| 2| 3| 8| 5| 8| 6| 6| 2| 3| 6| 7| 2| 2| 7| 7| 8| 3| 5| 5| 5| 9| 9| 9| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 6| 6| 6| 6|
300 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 2 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 2 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M M + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
Abscess | |
Acanthosis | |
Hyperkeratosis | |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05100-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICRESYL PHOSPHATE Date: 04/24/97
Route: DOSED FEED Time: 12:16:39
_____________________________________________________________________________________________________________________
| 0| 0| 2| 4| 2| 0| 0| 0| 0| 0| 4| 0| 0| 4| 4| 2| 2| 4| 4| 4| 5| 7| 7| 7| 6|
DAY ON TEST | 9| 9| 7| 5| 7| 9| 9| 9| 9| 9| 5| 9| 9| 5| 5| 7| 7| 5| 5| 5| 8| 2| 2| 2| 9|
| 2| 3| 8| 5| 8| 6| 6| 2| 3| 6| 7| 2| 2| 7| 7| 8| 3| 5| 5| 5| 9| 9| 9| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 6| 6| 6| 6|
300 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | X |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nerve, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 4 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Lens, Cataract, Focal | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy | 1 1 1 1 1 1 4 3 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + +|
Mucosa, Ulcer | |
_________________________________________________________