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https://ntp.niehs.nih.gov/go/1695

TDMS Study 05102-06 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                       BENZETHONIUM CHLORIDE


NTP Experiment-Test: 05102-06                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:18




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  121-54-0

       Lock Date:  01/22/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05102-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                         0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                  8            7           10            6                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10            4            8           13                                     
    Natural Death                                      3           15            9            7                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           34           31           34                                     
  Other                                                                          2                                                  
  Animals Examined Microscopically                    60           60           58           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (60)                                   (59)                                   
      Ulcer                                                                                   1 (2%)                                
   Intestine Large, Rectum                            (60)                                   (59)                                   
      Artery, Inflammation, Chronic Active                                                    1 (2%)                                
   Intestine Small, Duodenum                          (59)                                   (59)                                   
      Erosion                                          2 (3%)                                                                       
   Intestine Small, Ileum                             (60)                                   (58)                                   
      Inflammation, Acute                                                                     1 (2%)                                
   Liver                                              (60)                                   (60)                                   
      Angiectasis                                      2 (3%)                                 1 (2%)                                
      Basophilic Focus                                 1 (2%)                                 3 (5%)                                
      Clear Cell Focus                                 1 (2%)                                 1 (2%)                                
      Developmental Malformation                       1 (2%)                                                                       
      Eosinophilic Focus                              12 (20%)                               17 (28%)                               
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 2 (3%)                                 1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic Active                     3 (5%)                                                                       
      Mixed Cell Focus                                 2 (3%)                                 3 (5%)                                
      Necrosis                                         5 (8%)                                                                       
      Bile Duct, Cyst                                                                         1 (2%)                                
      Centrilobular, Fatty Change                      1 (2%)                                                                       
      Hepatocyte, Hyperplasia                          1 (2%)                                 1 (2%)                                
   Mesentery                                          (10)                                   (9)                                    
      Inflammation, Chronic Active                                                            1 (11%)                               
      Inflammation, Suppurative                        2 (20%)                                1 (11%)                               
      Fat, Necrosis                                    6 (60%)                                5 (56%)                               
   Pancreas                                           (60)                                   (59)                                   
      Atrophy                                          2 (3%)                                 5 (8%)                                
      Atypia Cellular                                  1 (2%)                                 2 (3%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05102-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                         0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic Active                                                            1 (2%)                                
      Duct, Cyst                                                                              3 (5%)                                
   Stomach, Forestomach                               (59)                                   (59)                                   
      Erosion                                          1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                 2 (3%)                                
   Stomach, Glandular                                 (59)                                   (59)                                   
      Erosion                                          1 (2%)                                                                       
      Inflammation, Acute                                                                     1 (2%)                                
      Mineralization                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)                                   (60)                                   
      Degeneration                                                                            1 (2%)                                
      Inflammation, Chronic Active                     3 (5%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)                                   (60)                                   
      Accessory Adrenal Cortical Nodule                4 (7%)                                 3 (5%)                                
      Hyperplasia                                      3 (5%)                                 1 (2%)                                
      Capsule, Hyperplasia, Adenomatous                1 (2%)                                                                       
   Adrenal Medulla                                    (59)                                   (60)                                   
      Hyperplasia                                      4 (7%)                                 2 (3%)                                
   Islets, Pancreatic                                 (60)                                   (58)                                   
      Hyperplasia                                      2 (3%)                                 3 (5%)                                
   Pituitary Gland                                    (60)                                   (55)                                   
      Angiectasis                                      2 (3%)                                                                       
      Pars Distalis, Hyperplasia                      27 (45%)                               30 (55%)                               
   Thyroid Gland                                      (60)                                   (60)                                   
      Follicle, Cyst                                   3 (5%)                                                                       
      Follicular Cell, Hyperplasia                    20 (33%)                               21 (35%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05102-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                         0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                                            (1)                                    
      Duct, Ectasia                                                                           1 (100%)                              
   Ovary                                              (60)                                   (58)                                   
      Angiectasis                                                                             1 (2%)                                
      Cyst                                            27 (45%)                               17 (29%)                               
      Cyst Dermoid                                                                            1 (2%)                                
      Inflammation, Suppurative                        2 (3%)                                 1 (2%)                                
      Interstitium, Hyperplasia                        1 (2%)                                 2 (3%)                                
   Uterus                                             (60)                                   (59)                                   
      Angiectasis                                      1 (2%)                                 1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Hyperplasia, Cystic                             39 (65%)                               43 (73%)                               
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)                                   (59)                                   
      Myelofibrosis                                   13 (22%)                               13 (22%)                               
      Erythroid Cell, Hyperplasia                      9 (15%)                                3 (5%)                                
      Myeloid Cell, Hyperplasia                        6 (10%)                                4 (7%)                                
   Lymph Node                                         (7)                                    (3)                                    
      Mediastinal, Necrosis                            1 (14%)                                                                      
      Pancreatic, Hyperplasia                                                                 1 (33%)                               
   Lymph Node, Mandibular                             (60)                                   (60)                                   
      Atrophy                                          1 (2%)                                                                       
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
      Hyperplasia, Lymphoid                            2 (3%)                                 1 (2%)                                
   Lymph Node, Mesenteric                             (57)                                   (54)                                   
      Atrophy                                          1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                 2 (4%)                                
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
   Spleen                                             (60)                                   (59)                                   
      Angiectasis                                      1 (2%)                                                                       
      Depletion Lymphoid                               2 (3%)                                                                       
      Hematopoietic Cell Proliferation                16 (27%)                               24 (41%)                               
      Hyperplasia, Lymphoid                            1 (2%)                                 1 (2%)                                
      Hyperplasia, Macrophage                                                                 1 (2%)                                
   Thymus                                             (49)                                   (51)                                   
      Depletion Lymphoid                               5 (10%)                                7 (14%)                               
      Hyperplasia, Lymphoid                            3 (6%)                                 4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05102-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                         0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)                                   (58)                                   
      Hyperplasia                                      3 (5%)                                 2 (3%)                                
   Skin, Inguinal                                                  (2)          (1)          (1)                                    
      Acanthosis                                                                 1 (100%)                                           
      Inflammation, Chronic Active                                  1 (50%)                                                         
   Skin, Site of Application-No Mass                  (5)          (10)         (9)          (27)                                   
      Acanthosis                                       3 (60%)      7 (70%)      9 (100%)    26 (96%)                               
      Inflammation, Chronic Active                     1 (20%)      2 (20%)                                                         
      Ulcer                                                                      2 (22%)                                            
      Sebaceous Gland, Hyperplasia                                               1 (11%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)                                   (59)                                   
      Osteopetrosis                                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)                                   (59)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Hydrocephalus                                                                           1 (2%)                                
      Neuron, Necrosis                                 1 (2%)                                 1 (2%)                                
   Peripheral Nerve                                                                          (2)                                    
      Degeneration                                                                            2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)                                   (60)                                   
      Hemorrhage                                                                              1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 3 (5%)                                 3 (5%)                                
      Alveolus, Pigmentation, Hemosiderin              2 (3%)                                 2 (3%)                                
      Pleura, Infiltration Cellular, Lymphocyte        1 (2%)                                                                       
      Pleura, Inflammation                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)                                    (2)                                    
      Degeneration                                     3 (75%)                                                                      
      Cornea, Inflammation                             1 (25%)                                1 (50%)                               
   Harderian Gland                                    (44)                                   (35)                                   
      Hyperplasia                                      1 (2%)                                 2 (6%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05102-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                         0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)                                   (60)                                   
      Glomerulosclerosis                               1 (2%)                                 1 (2%)                                
      Nephropathy                                     33 (55%)                               39 (65%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05102-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                           0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            9            9           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 3            8            4            9                                     
    Natural Death                                      4            4            4            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           38           42           39                                     
  Other                                                             1            1                                                  
  Animals Examined Microscopically                    60           59           59           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (60)                                   (60)                                   
      Erosion                                          1 (2%)                                                                       
   Intestine Small, Jejunum                           (60)                                   (60)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                 1 (2%)                                
      Inflammation, Chronic Active                                                            1 (2%)                                
   Liver                                              (60)                                   (60)                                   
      Basophilic Focus                                 2 (3%)                                 5 (8%)                                
      Clear Cell Focus                                13 (22%)                               12 (20%)                               
      Eosinophilic Focus                              14 (23%)                               16 (27%)                               
      Fatty Change, Focal                                                                     1 (2%)                                
      Hematopoietic Cell Proliferation                 2 (3%)                                                                       
      Infarct                                          1 (2%)                                                                       
      Mixed Cell Focus                                 5 (8%)                                 4 (7%)                                
      Necrosis                                         1 (2%)                                 2 (3%)                                
   Mesentery                                          (5)                                    (5)                                    
      Inflammation, Chronic Active                                                            1 (20%)                               
      Fat, Necrosis                                    4 (80%)                                1 (20%)                               
      Vein, Thrombosis                                                                        1 (20%)                               
   Pancreas                                           (60)                                   (60)                                   
      Atrophy                                          3 (5%)                                 4 (7%)                                
      Atypia Cellular                                  4 (7%)                                 2 (3%)                                
      Concretion                                                                              1 (2%)                                
      Cytoplasmic Alteration                           1 (2%)                                                                       
      Necrosis                                                                                1 (2%)                                
      Duct, Cyst                                                                              1 (2%)                                
   Salivary Glands                                    (60)                                   (60)                                   
      Atrophy                                          1 (2%)                                                                       
   Stomach, Forestomach                               (60)                                   (60)                                   
      Erosion                                                                                 2 (3%)                                
      Hyperplasia                                      1 (2%)                                 4 (7%)                                
   Stomach, Glandular                                 (60)                                   (60)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05102-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                           0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Erosion                                          1 (2%)                                                                       
   Tooth                                              (1)                                    (2)                                    
      Inflammation, Chronic Active                                                            1 (50%)                               
      Inflammation, Suppurative                        1 (100%)                               1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)                                   (60)                                   
      Inflammation, Chronic Active                     2 (3%)                                 2 (3%)                                
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
      Valve, Inflammation, Chronic Active                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)                                   (60)                                   
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
      Hyperplasia                                     40 (67%)                               33 (55%)                               
      Capsule, Hyperplasia, Adenomatous                5 (8%)                                 9 (15%)                               
   Islets, Pancreatic                                 (59)                                   (60)                                   
      Hyperplasia                                     22 (37%)                               19 (32%)                               
   Parathyroid Gland                                  (56)                                   (55)                                   
      Cyst                                             1 (2%)                                                                       
   Pituitary Gland                                    (58)                                   (58)                                   
      Cyst                                             2 (3%)                                 2 (3%)                                
      Pars Distalis, Hyperplasia                                                              2 (3%)                                
      Pars Intermedia, Hyperplasia                     3 (5%)                                 1 (2%)                                
   Thyroid Gland                                      (60)                                   (60)                                   
      Inflammation                                                                            1 (2%)                                
      Ultimobranchial Cyst                             1 (2%)                                                                       
      Follicle, Cyst                                   3 (5%)                                 1 (2%)                                
      Follicular Cell, Hyperplasia                    10 (17%)                                7 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                (1)                                    
      Hemorrhage                                                                              1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)                                   (59)                                   
      Inflammation                                     3 (5%)                                 5 (8%)                                
   Preputial Gland                                    (19)                                   (18)                                   
      Inflammation, Chronic Active                     6 (32%)                                3 (17%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05102-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                           0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Duct, Ectasia                                   19 (100%)                              17 (94%)                               
   Prostate                                           (59)                                   (60)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
      Artery, Inflammation, Chronic Active                                                    1 (2%)                                
   Seminal Vesicle                                    (60)                                   (60)                                   
      Inflammation                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)                                   (60)                                   
      Erythroid Cell, Hyperplasia                      4 (7%)                                12 (20%)                               
      Myeloid Cell, Hyperplasia                        3 (5%)                                 4 (7%)                                
   Lymph Node, Mandibular                             (59)                                   (58)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
   Lymph Node, Mesenteric                             (57)                                   (57)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Inflammation, Granulomatous                                                             1 (2%)                                
   Spleen                                             (60)                                   (60)                                   
      Depletion Lymphoid                               3 (5%)                                                                       
      Hematopoietic Cell Proliferation                12 (20%)                               22 (37%)                               
      Hyperplasia, Lymphoid                            1 (2%)                                 1 (2%)                                
      Inflammation, Granulomatous                                                             1 (2%)                                
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Thymus                                             (41)                                   (49)                                   
      Depletion Lymphoid                               4 (10%)                                3 (6%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin, Site of Application-No Mass                  (2)          (7)          (18)         (34)                                   
      Acanthosis                                       2 (100%)     7 (100%)    18 (100%)    33 (97%)                               
      Inflammation, Chronic Active                                                            2 (6%)                                
      Ulcer                                            1 (50%)      1 (14%)      4 (22%)      2 (6%)                                
      Sebaceous Gland, Hyperplasia                                               1 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05102-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                           0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)                                   (60)                                   
      Neuron, Necrosis                                 2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)                                   (60)                                   
      Thrombosis                                                                              2 (3%)                                
      Alveolar Epithelium, Hyperplasia                 6 (10%)                                3 (5%)                                
      Bronchiole, Hyperplasia                                                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                    (2)                                    
      Necrosis                                                                                1 (50%)                               
   Eye                                                (1)                                    (1)                                    
      Cornea, Inflammation                             1 (100%)                               1 (100%)                              
   Harderian Gland                                    (43)                                   (38)                                   
      Hyperplasia                                      2 (5%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)                                   (60)                                   
      Cyst                                                                                    1 (2%)                                
      Hydronephrosis                                   2 (3%)                                 1 (2%)                                
      Nephropathy                                     58 (97%)                               58 (97%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
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                             ----------              END OF REPORT             ----------                                           
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