TDMS Study 05102-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus BENZETHONIUM CHLORIDE DATE: 05/19/95
EXPERIMENT: 05102 TEST: 06 TIME: 18:49:18
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-75177 ROUTE: DERMAL,SOLUTION NTP C#: 61494B
PATHOLOGIST: A. SINGER S. EUSTIS CAS: 121-54-0
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus BENZETHONIUM CHLORIDE DATE: 05/19/95
EXPERIMENT: 05102 TEST: 06 TIME: 18:49:18
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75177 ROUTE: DERMAL,SOLUTION NTP C#: 61494B
PATHOLOGIST: A. SINGER S. EUSTIS CAS: 121-54-0
BENZETHONIUM CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 7 CENSORED DEATHS 10 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 577 603 613 637 655 717 719 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .15MG/KG |
| --------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 12 CENSORED DEATHS 9 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 513 571 621 624 695 701 703 712 712 717 |
| 719 721 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5MG/KG |
| --------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 8 CENSORED DEATHS 9 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 560 635 638 660 663 684 713 727 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
BENZETHONIUM CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.5MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 10 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 518 584 612 659 684 687 695 705 712 719 |
| 725 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
BENZETHONIUM CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 90.0 86.0 |
| | |
| | |
|.15MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 96.0 92.0 76.0 |
| | |
| | |
|0.5MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 90.0 84.0 |
| | |
| | |
|1.5MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 96.0 92.0 78.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0MG/KG .15MG/KG 0.5MG/KG 1.5MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 86.0% 76.0% 84.0% 78.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.671 P=0.320 P=1.000 P=0.449 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 645.9 667.4 660.0 663.6 |
|NATURAL DEATHS (C) | (20.8) (19.9) (18.4) (19.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 673.8 674.8 678.0 671.5 |
|(STANDARD ERROR) | (13.3) (13.2) (13.0) (13.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BENZETHONIUM CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 9 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 317 428 568 632 660 674 677 687 689 691 |
| 698 719 722 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 639 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .15MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 19 CENSORED DEATHS 7 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 268 308 372 459 471 512 518 543 565 583 |
| 596 597 613 626 635 656 699 701 715 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5MG/KG |
| --------------------- |
| |
| TOTAL 58 UNCENSORED DEATHS 17 CENSORED DEATHS 10 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 526 568 591 591 609 621 648 664 674 677 |
| 690 697 698 704 712 717 718 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
BENZETHONIUM CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.5MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 6 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 120 249 316 428 479 485 520 551 589 612 |
| 647 682 689 690 691 695 698 698 698 720 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 |
| |
==================================================================================
BENZETHONIUM CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0MG/KG | 100.0 100.0 100.0 98.3 98.3 96.7 96.7 94.7 90.8 75.0 |
| | |
| | |
|.15MG/KG | 100.0 100.0 98.3 96.7 95.0 91.2 85.5 77.9 70.3 64.6 |
| | |
| | |
|0.5MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 97.9 91.7 83.3 64.6 |
| | |
| | |
|1.5MG/KG | 100.0 98.3 96.7 95.0 95.0 89.6 87.7 84.0 80.3 63.5 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0MG/KG .15MG/KG 0.5MG/KG 1.5MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 75.0% 64.6% 64.6% 63.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.406 P=0.222 P=0.373 P=0.226 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 627.8 549.3 653.2 562.9 |
|NATURAL DEATHS (C) | (33.9) (29.3) (14.2) (38.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 669.2 640.3 659.7 646.3 |
|(STANDARD ERROR) | (14.1) (16.4) (13.7) (18.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BENZETHONIUM CHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
0MG/KG = 1
.15MG/KG = 2
0.5MG/KG = 3
1.5MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
|
| 2 3 214 1 3
|
P 96 + 2 4 112 33
E |
R | 12213 3
C |
E 92 + 21 1 4 4 2
N |
T | 1 3 3422 1
|
S 88 + 344 3
U |
R | 42213 1
V |
I 84 + 44 3 3
V |
A | 22
L |
80 + 44
|
| 4 4
|
76 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 13 obs hidden.
BENZETHONIUM CHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
0MG/KG = 1
.15MG/KG = 2
0.5MG/KG = 3
1.5MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 1 3
| 4 4 2 2 1 1
| 3 3
| 4 2 4 2 1 1 3
95 + 4 2 4 2 1 1
| 4 4
| 2 2 1 1
| 244 2 3 3 1 1
P 90 + 4 4 3 3
E |
R | 2 4 24 3 3 1 1
C | 4 4
E 85 + 2 2 3 3
N | 2 2 4 4 3 3
T | 4 4
| 2 2 11
S 80 + 4 4
U | 3431 1
R | 2 2 33 11
V | 2 2
I 75 + 1 1
V | 22
A | 2 2 433
L | 33
70 + 2 2
| 2233
|
| 2 2
65 + 4 2 2
| 4 4
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.