Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/1707

TDMS Study 05102-05 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                       BENZETHONIUM CHLORIDE


NTP Experiment-Test: 05102-05                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  121-54-0

       Lock Date:  01/24/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                  9            7            9            7                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13           11           13           13                                     
    Natural Death                                     14            9           12           16                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           33           26           24                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (2)                                                                           
      Ulcer                                            2 (100%)                                                                     
   Liver                                              (60)                                   (60)                                   
      Angiectasis                                      2 (3%)                                                                       
      Basophilic Focus                                26 (43%)                               33 (55%)                               
      Clear Cell Focus                                 2 (3%)                                 7 (12%)                               
      Eosinophilic Focus                              13 (22%)                               13 (22%)                               
      Hepatodiaphragmatic Nodule                       9 (15%)                               18 (30%)                               
      Hepatodiaphragmatic Nodule, Multiple             1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (3%)                                 2 (3%)                                
      Inflammation, Granulomatous                      8 (13%)                               11 (18%)                               
      Bile Duct, Hyperplasia                          11 (18%)                               13 (22%)                               
      Hepatocyte, Degeneration, Cystic                                                        2 (3%)                                
      Hepatocyte, Hypertrophy, Focal                                                          1 (2%)                                
      Hepatocyte, Necrosis                             1 (2%)                                                                       
      Hepatocyte, Vacuolization Cytoplasmic            7 (12%)                                8 (13%)                               
   Mesentery                                          (4)                                    (4)                                    
      Fat, Inflammation, Chronic Active                3 (75%)                                4 (100%)                              
   Pancreas                                           (60)                                   (60)                                   
      Inflammation, Chronic Active                                                            1 (2%)                                
      Acinus, Atrophy                                 15 (25%)                               17 (28%)                               
   Stomach, Forestomach                               (6)                                    (8)                                    
      Acanthosis                                                                              3 (38%)                               
      Inflammation, Chronic Active                                                            1 (13%)                               
      Mineralization                                                                          1 (13%)                               
      Ulcer                                            6 (100%)                               5 (63%)                               
   Stomach, Glandular                                 (1)                                                                           
      Necrosis                                         1 (100%)                                                                     
   Tongue                                                                                    (1)                                    
      Cyst                                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)                                   (60)                                   
      Degeneration, Chronic                           29 (48%)                               33 (55%)                               
      Atrium, Thrombosis                               3 (5%)                                 3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (19)                                   (21)                                   
      Degeneration, Cystic                             1 (5%)                                 1 (5%)                                
      Hyperplasia                                      7 (37%)                               12 (57%)                               
      Hypertrophy                                                                             1 (5%)                                
      Necrosis                                         2 (11%)                                2 (10%)                               
      Vacuolization Cytoplasmic                        8 (42%)                                9 (43%)                               
   Adrenal Medulla                                    (10)                                   (2)                                    
      Hyperplasia                                      6 (60%)                                1 (50%)                               
   Parathyroid Gland                                  (56)                                   (53)                                   
      Hyperplasia                                     32 (57%)                               32 (60%)                               
   Pituitary Gland                                    (60)                                   (60)                                   
      Necrosis                                         1 (2%)                                                                       
      Craniopharyngeal Duct, Pars Distalis, Cyst                                              1 (2%)                                
      Pars Distalis, Cyst                             11 (18%)                               12 (20%)                               
      Pars Distalis, Hyperplasia                      17 (28%)                               20 (33%)                               
   Thyroid Gland                                      (60)                                   (60)                                   
      Bilateral, Ultimobranchial Cyst                                                         1 (2%)                                
      C-Cell, Hyperplasia                             24 (40%)                               17 (28%)                               
      Follicular Cell, Hyperplasia                                                            2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)                                   (59)                                   
      Hyperplasia                                      5 (8%)                                 4 (7%)                                
      Inflammation, Chronic Active                     2 (3%)                                 1 (2%)                                
      Duct, Cyst                                       1 (2%)                                                                       
      Duct, Ectasia                                    1 (2%)                                 2 (3%)                                
   Ovary                                              (60)                                   (60)                                   
      Follicle, Cyst                                   4 (7%)                                 7 (12%)                               
      Periovarian Tissue, Cyst                         8 (13%)                               13 (22%)                               
   Uterus                                             (60)                                   (60)                                   
      Endometrium, Hyperplasia, Cystic, Glandular      3 (5%)                                 3 (5%)                                
   Vagina                                             (1)                                                                           
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Lumen, Hemorrhage                                1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)                                                                           
      Erythrocyte, Atypia Cellular                     1 (50%)                                                                      
   Bone Marrow                                        (60)                                   (59)                                   
      Femoral, Myelofibrosis                           1 (2%)                                                                       
   Lymph Node, Mandibular                             (7)                                    (3)                                    
      Thrombosis                                       1 (14%)                                                                      
   Lymph Node, Mesenteric                             (5)                                    (3)                                    
      Angiectasis                                                                             2 (67%)                               
   Spleen                                             (60)                                   (60)                                   
      Fibrosis                                         1 (2%)                                 2 (3%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                 2 (3%)                                
   Thymus                                             (54)                                   (56)                                   
      Angiectasis                                                                             1 (2%)                                
      Cyst                                                                                    1 (2%)                                
      Depletion Lymphoid                               8 (15%)                                9 (16%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)                                   (60)                                   
      Hyperplasia, Cystic                             58 (97%)                               56 (93%)                               
   Skin                                               (60)         (60)         (60)         (60)                                   
      Acanthosis                                                    2 (3%)       1 (2%)                                             
      Hyperkeratosis                                                             1 (2%)                                             
   Skin, Control                                                   (1)          (1)                                                 
      Acanthosis                                                    1 (100%)     1 (100%)                                           
      Sebaceous Gland, Hyperplasia                                  1 (100%)     1 (100%)                                           
   Skin, Site of Application-No Mass                  (2)          (3)          (8)          (39)                                   
      Acanthosis                                       2 (100%)     3 (100%)     8 (100%)    38 (97%)                               
      Erosion, Focal                                                                          1 (3%)                                
      Ulcer                                                         2 (67%)      4 (50%)     23 (59%)                               
      Sebaceous Gland, Hyperplasia                     1 (50%)      3 (100%)     7 (88%)     36 (92%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)                                   (60)                                   
      Femur, Hyperostosis                              2 (3%)                                 2 (3%)                                
      Femur, Osteopetrosis                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)                                   (60)                                   
      Compression                                     21 (35%)                               17 (28%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Hydrocephalus                                    8 (13%)                                6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)                                   (60)                                   
      Inflammation, Chronic Active                     2 (3%)                                 2 (3%)                                
      Alveolar Epithelium, Hyperplasia                                                        1 (2%)                                
      Perivascular, Inflammation, Chronic              1 (2%)                                                                       
   Nose                                               (60)                                   (60)                                   
      Mucosa, Inflammation, Chronic Active             4 (7%)                                 5 (8%)                                
      Sinus, Foreign Body                              3 (5%)                                 5 (8%)                                
      Submucosa, Inflammation, Chronic                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (6)                                    (4)                                    
      Phthisis Bulbi                                   1 (17%)                                                                      
      Lens, Cataract                                   5 (83%)                                4 (100%)                              
      Retina, Atrophy                                  5 (83%)                                4 (100%)                              
   Harderian Gland                                    (1)                                    (1)                                    
      Inflammation, Chronic Active                     1 (100%)                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)                                   (60)                                   
      Cyst                                             1 (2%)                                                                       
      Mineralization                                   8 (13%)                                9 (15%)                               
      Nephropathy, Chronic                            48 (80%)                               53 (88%)                               
   Urinary Bladder                                    (60)                                   (60)                                   
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                  8            8            5            4                                     
  Early Deaths                                                                                                                      
    Natural Death                                     12            7           11           15                                     
    Moribund Sacrifice                                25           34           34           25                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Natural Death                                                                1                                                  
    Terminal Sacrifice                                15           11            8           16                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                                                                 (3)                                    
      Dysplasia                                                                               1 (33%)                               
      Ulcer                                                                                   1 (33%)                               
   Intestine Small, Jejunum                           (2)                                    (1)                                    
      Inflammation, Chronic                            1 (50%)                                                                      
   Liver                                              (60)                                   (60)                                   
      Basophilic Focus                                 6 (10%)                                7 (12%)                               
      Clear Cell Focus                                 3 (5%)                                 3 (5%)                                
      Eosinophilic Focus                               4 (7%)                                 3 (5%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       6 (10%)                                4 (7%)                                
      Inflammation, Chronic Active                     3 (5%)                                 3 (5%)                                
      Inflammation, Granulomatous                      2 (3%)                                 3 (5%)                                
      Bile Duct, Cyst                                                                         1 (2%)                                
      Bile Duct, Hyperplasia                          37 (62%)                               38 (63%)                               
      Hepatocyte, Degeneration, Cystic                 4 (7%)                                 9 (15%)                               
      Hepatocyte, Hyperplasia                                                                 1 (2%)                                
      Hepatocyte, Vacuolization Cytoplasmic           22 (37%)                               21 (35%)                               
   Mesentery                                          (8)                                    (8)                                    
      Artery, Inflammation, Chronic Active             1 (13%)                                1 (13%)                               
      Fat, Hemorrhage                                  1 (13%)                                                                      
      Fat, Inflammation, Chronic Active                3 (38%)                                6 (75%)                               
   Pancreas                                           (60)                                   (60)                                   
      Acinus, Atrophy                                 23 (38%)                               26 (43%)                               
      Artery, Inflammation, Chronic Active             1 (2%)                                 1 (2%)                                
   Stomach, Forestomach                               (10)                                   (13)                                   
      Acanthosis                                       4 (40%)                                2 (15%)                               
      Inflammation, Chronic Active                     1 (10%)                                2 (15%)                               
      Mineralization                                   1 (10%)                                2 (15%)                               
      Ulcer                                            5 (50%)                                8 (62%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Glandular                                 (13)                                   (11)                                   
      Dysplasia                                        2 (15%)                                                                      
      Hyperplasia                                                                             1 (9%)                                
      Mineralization                                   5 (38%)                                3 (27%)                               
      Necrosis                                         1 (8%)                                 2 (18%)                               
      Pigmentation, Hemosiderin                        1 (8%)                                                                       
      Ulcer                                            4 (31%)                                5 (45%)                               
   Tongue                                             (1)                                                                           
      Inflammation, Chronic Active                     1 (100%)                                                                     
   Tooth                                              (2)                                                                           
      Peridontal Tissue, Inflammation, Chronic                                                                                      
          Active                                       1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                    (1)                                    
      Aorta, Mineralization                            1 (100%)                               1 (100%)                              
   Heart                                              (59)                                   (60)                                   
      Degeneration, Chronic                           51 (86%)                               50 (83%)                               
      Mineralization                                   1 (2%)                                 2 (3%)                                
      Atrium, Thrombosis                               6 (10%)                                4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (29)                                   (24)                                   
      Hyperplasia                                     13 (45%)                                6 (25%)                               
      Hypertrophy                                      2 (7%)                                                                       
      Vacuolization Cytoplasmic                       22 (76%)                               20 (83%)                               
   Adrenal Medulla                                    (27)                                   (29)                                   
      Hyperplasia                                     24 (89%)                               21 (72%)                               
   Islets, Pancreatic                                 (60)                                   (60)                                   
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
   Parathyroid Gland                                  (58)                                   (58)                                   
      Hyperplasia                                     37 (64%)                               39 (67%)                               
   Pituitary Gland                                    (60)                                   (60)                                   
      Pars Distalis, Cyst                              7 (12%)                                                                      
      Pars Distalis, Hemorrhage                                                               2 (3%)                                
      Pars Distalis, Hyperplasia                      13 (22%)                               11 (18%)                               
      Pars Distalis, Vacuolization Cytoplasmic                                                2 (3%)                                
   Thyroid Gland                                      (59)                                   (60)                                   
      Ultimobranchial Cyst                                                                    1 (2%)                                
      C-Cell, Hyperplasia                             12 (20%)                               11 (18%)                               
      Follicle, Cyst                                                                          1 (2%)                                
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)                                   (60)                                   
      Aspermia                                                                                2 (3%)                                
      Inflammation, Granulomatous                                                             1 (2%)                                
   Preputial Gland                                    (60)                                   (60)                                   
      Inflammation, Chronic Active                    46 (77%)                               38 (63%)                               
      Duct, Ectasia                                    1 (2%)                                 2 (3%)                                
   Prostate                                           (60)                                   (60)                                   
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Chronic Active                    30 (50%)                               26 (43%)                               
      Inflammation, Granulomatous                                                             1 (2%)                                
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Seminal Vesicle                                    (60)                                   (60)                                   
      Atrophy                                                                                 1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                 2 (3%)                                
      Mineralization                                   1 (2%)                                                                       
   Testes                                             (60)                                   (60)                                   
      Cyst                                                                                    1 (2%)                                
      Germinal Epithelium, Degeneration               16 (27%)                               17 (28%)                               
      Interstitial Cell, Hyperplasia                  17 (28%)                               13 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)                                   (60)                                   
      Femoral, Myelofibrosis                           4 (7%)                                 4 (7%)                                
   Lymph Node                                         (8)                                    (14)                                   
      Mediastinal, Congestion                                                                 1 (7%)                                
      Mediastinal, Inflammation, Chronic Active                                               1 (7%)                                
      Pancreatic, Angiectasis                          1 (13%)                                                                      
   Lymph Node, Mandibular                             (13)                                   (17)                                   
      Hyperplasia, Lymphoid                            1 (8%)                                                                       
      Infiltration Cellular, Plasma Cell                                                      1 (6%)                                
   Lymph Node, Mesenteric                             (9)                                    (14)                                   
      Angiectasis                                      1 (11%)                                                                      
      Hyperplasia, Lymphoid                                                                   1 (7%)                                
      Inflammation, Chronic Active                                                            1 (7%)                                
   Spleen                                             (60)                                   (60)                                   
      Fibrosis                                        14 (23%)                                7 (12%)                               
      Infarct                                                                                 1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Capsule, Thrombosis                                                                     1 (2%)                                
   Thymus                                             (52)                                   (51)                                   
      Depletion Lymphoid                               9 (17%)                                7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (55)                                   (53)                                   
      Hyperplasia, Cystic                             50 (91%)                               49 (92%)                               
      Duct, Cyst                                                                              1 (2%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Acanthosis                                       3 (5%)       2 (3%)                    1 (2%)                                
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Hyperkeratosis                                   1 (2%)                    1 (2%)       1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
   Skin, Control                                      (3)          (3)          (2)          (1)                                    
      Acanthosis                                       3 (100%)     3 (100%)     1 (50%)      1 (100%)                              
      Hyperplasia, Basal Cell                                                    1 (50%)                                            
      Dermis, Inflammation, Chronic                                 1 (33%)                                                         
   Skin, Site of Application-No Mass                  (2)          (1)          (8)          (16)                                   
      Acanthosis                                       1 (50%)                   6 (75%)     14 (88%)                               
      Acanthosis, Multifocal                                                     1 (13%)                                            
      Cyst                                                                                    1 (6%)                                
   Skin, Site of Application-Mass                     (5)                       (3)          (4)                                    
      Cyst Epithelial Inclusion                        1 (20%)                                2 (50%)                               
   Skin, Site of Application-No Mass                  (2)          (1)          (8)          (16)                                   
      Hyperkeratosis                                                                          2 (13%)                               
      Ulcer                                                                                   1 (6%)                                
   Skin, Site of Application-Mass                     (5)                       (3)          (4)                                    
      Dermis, Fibrosis                                 3 (60%)                                1 (25%)                               
      Dermis, Mineralization                           2 (40%)                                                                      
   Skin, Site of Application-No Mass                  (2)          (1)          (8)          (16)                                   
      Sebaceous Gland, Hyperplasia                                               4 (50%)      4 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)                                   (60)                                   
      Tarsal, Fracture                                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)                                   (60)                                   
      Compression                                     14 (23%)                               13 (22%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Hydrocephalus                                   10 (17%)                                6 (10%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)                                   (60)                                   
      Inflammation, Chronic Active                     3 (5%)                                 2 (3%)                                
      Inflammation, Granulomatous                                                             1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                   1 (2%)                                 2 (3%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)                                                                       
   Nose                                               (60)                                   (59)                                   
      Lumen, Hemorrhage                                                                       1 (2%)                                
      Mucosa, Inflammation, Chronic Active             6 (10%)                                6 (10%)                               
      Mucosa, Ulcer                                                                           1 (2%)                                
      Sinus, Foreign Body                              6 (10%)                                2 (3%)                                
      Submucosa, Inflammation, Acute                   1 (2%)                                                                       
   Trachea                                            (59)                                   (60)                                   
      Submucosa, Inflammation, Chronic                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                                    (3)                                    
      Lens, Cataract                                   2 (100%)                               2 (67%)                               
      Retina, Atrophy                                  2 (100%)                               2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)                                   (60)                                   
      Cyst                                                                                    1 (2%)                                
      Nephropathy, Chronic                            60 (100%)                              60 (100%)                              
      Cortex, Cyst                                     1 (2%)                                                                       
      Cortex, Renal Tubule, Mineralization             1 (2%)                                                                       
   Urinary Bladder                                    (60)                                   (60)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------