TDMS Study 05102-05 Pathology Tables
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
Facility: Battelle Columbus Laboratory
Chemical CAS #: 121-54-0
Lock Date: 01/24/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 4| 6| 4| 5| 7| 7| 4| 7| 7| 1| 7| 6| 4| 6| 6| 6| 7| 7|
DAY ON TEST | 3| 2| 4| 3| 3| 3| 7| 5| 9| 5| 1| 3| 2| 5| 3| 3| 7| 3| 4| 5| 1| 4| 4| 3| 3|
| 1| 4| 8| 1| 1| 1| 2| 6| 6| 6| 9| 1| 4| 6| 1| 1| 6| 1| 9| 6| 0| 4| 2| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
Peyer's Patch, Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Fat, Liposarcoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + |
__________________________________________________________________________|
Stomach, Glandular | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + |
Leukemia Mononuclear | |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Adenoma, Multiple | |
Pars Distalis, Carcinoma | X |
Pars Distalis, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 4| 6| 4| 5| 7| 7| 4| 7| 7| 1| 7| 6| 4| 6| 6| 6| 7| 7|
DAY ON TEST | 3| 2| 4| 3| 3| 3| 7| 5| 9| 5| 1| 3| 2| 5| 3| 3| 7| 3| 4| 5| 1| 4| 4| 3| 3|
| 1| 4| 8| 1| 1| 1| 2| 6| 6| 6| 9| 1| 4| 6| 1| 1| 6| 1| 9| 6| 0| 4| 2| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Adenoma, Multiple | X |
Fibroadenoma | X X X |
Fibroadenoma, Multiple | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Benign | |
Subcutaneous Tissue, Lipoma | X |
__________________________________________________________________________|
Skin, Site of Application-No Mass | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 4| 6| 4| 5| 7| 7| 4| 7| 7| 1| 7| 6| 4| 6| 6| 6| 7| 7|
DAY ON TEST | 3| 2| 4| 3| 3| 3| 7| 5| 9| 5| 1| 3| 2| 5| 3| 3| 7| 3| 4| 5| 1| 4| 4| 3| 3|
| 1| 4| 8| 1| 1| 1| 2| 6| 6| 6| 9| 1| 4| 6| 1| 1| 6| 1| 9| 6| 0| 4| 2| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nares, Squamous Cell Papilloma | |
Vomeronasal Organ, Squamous Cell | |
Carcinoma | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + +|
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 6| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 5| 3| 3| 3| 3| 5| 2| 3| 8| 9| 3| 3| 4| 3| 2| 3| 6| 1| 3| 3| 3| 5| 3| 3|
| 6| 6| 1| 1| 3| 1| 4| 0| 1| 5| 5| 1| 1| 5| 1| 6| 1| 7| 9| 1| 1| 1| 6| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
Peyer's Patch, Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Fat, Liposarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + |
__________________________________________________________________________|
Stomach, Glandular | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X|
Pars Distalis, Adenoma, Multiple | X |
Pars Distalis, Carcinoma | |
Pars Distalis, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X X X|
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 6| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 5| 3| 3| 3| 3| 5| 2| 3| 8| 9| 3| 3| 4| 3| 2| 3| 6| 1| 3| 3| 3| 5| 3| 3|
| 6| 6| 1| 1| 3| 1| 4| 0| 1| 5| 5| 1| 1| 5| 1| 6| 1| 7| 9| 1| 1| 1| 6| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + M + + M + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Adenoma, Multiple | |
Fibroadenoma | X X X X X X X |
Fibroadenoma, Multiple | X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Benign | |
Subcutaneous Tissue, Lipoma | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 6| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 5| 3| 3| 3| 3| 5| 2| 3| 8| 9| 3| 3| 4| 3| 2| 3| 6| 1| 3| 3| 3| 5| 3| 3|
| 6| 6| 1| 1| 3| 1| 4| 0| 1| 5| 5| 1| 1| 5| 1| 6| 1| 7| 9| 1| 1| 1| 6| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nares, Squamous Cell Papilloma | X |
Vomeronasal Organ, Squamous Cell | |
Carcinoma | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 6| 5| 4| 7| 6| | |
DAY ON TEST | 1| 5| 3| 0| 2| 4| 1| 5| 0| 1| | |
| 8| 6| 1| 3| 2| 2| 5| 6| 9| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 1 |
Peyer's Patch, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X | 18 |
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Liposarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 6 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 19 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 10 |
Leukemia Mononuclear | X | 2 |
Pheochromocytoma Benign | | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M M | 56 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Adenoma | X X X X | 28 |
Pars Distalis, Adenoma, Multiple | | 1 |
Pars Distalis, Carcinoma | X | 2 |
Pars Distalis, Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | X | 10 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 6| 5| 4| 7| 6| | |
DAY ON TEST | 1| 5| 3| 0| 2| 4| 1| 5| 0| 1| | |
| 8| 6| 1| 3| 2| 2| 5| 6| 9| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + | 59 |
Adenoma | | 4 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Polyp Stromal | | 3 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Femoral, Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
Mediastinal, Leukemia Mononuclear | X | 4 |
Pancreatic, Leukemia Mononuclear | | 2 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 7 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 5 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X | 17 |
__________________________________________________________________________|____________|
Thymus | + + + + M + + + M + | 54 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Adenoma | | 2 |
Adenoma, Multiple | | 1 |
Fibroadenoma | X X X X | 14 |
Fibroadenoma, Multiple | | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Basosquamous Tumor Benign | X | 1 |
Subcutaneous Tissue, Lipoma | | 1 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 6| 5| 4| 7| 6| | |
DAY ON TEST | 1| 5| 3| 0| 2| 4| 1| 5| 0| 1| | |
| 8| 6| 1| 3| 2| 2| 5| 6| 9| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 2 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X X | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Nares, Squamous Cell Papilloma | | 1 |
Vomeronasal Organ, Squamous Cell | | |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 6 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 7| 5| 6| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 4| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 5| 0| 5| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3|
| 0| 1| 2| 6| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 9| 6| 0| 0| 6| 8| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.15 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Control | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 7| 7| 3| 7| 7| 4| 7| 3| 6| 6| 7| 6| 5| 7| 4| 6| 7| 7| 4| 6| 4|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 9| 3| 3| 5| 3| 6| 1| 3| 3| 8| 8| 3| 5| 1| 3| 3| 5| 7| 5|
| 8| 0| 6| 0| 0| 0| 3| 0| 0| 6| 0| 6| 2| 3| 0| 0| 2| 0| 6| 2| 0| 1| 6| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.15 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Control | + |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 2| 3| 8| 3| 3| 3| 3| 1| | |
| 1| 1| 7| 1| 4| 1| 1| 1| 1| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.15 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin, Control | | 1 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 5| 7| 4| 6| 4| 5| 4| 6| 4| 7| 6| 2| 7| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 7| 4| 2| 2| 7| 2| 5| 8| 5| 3| 5| 7| 5| 2| 3| 9| 0| 1| 2| 2| 2| 3| 0| 1| 3|
| 9| 9| 9| 9| 9| 9| 6| 6| 6| 3| 6| 8| 6| 9| 2| 7| 8| 0| 9| 9| 9| 0| 6| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Trichoepithelioma | |
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
__________________________________________________________________________|
Skin, Control | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 7| 4| 4| 4| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 4| 4| 6| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 5| 5| 5| 8| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 9| 6| 8| 3| 3| 3| 7| 2| 0|
| 0| 6| 6| 6| 1| 0| 0| 0| 0| 0| 8| 0| 0| 4| 8| 0| 2| 5| 5| 0| 0| 0| 9| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Trichoepithelioma | |
Subcutaneous Tissue, | |
Neurofibrosarcoma | X |
__________________________________________________________________________|
Skin, Control | + |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 5| 7| 4| 7| 7| 6| 7| 4| 7| 7| | |
DAY ON TEST | 6| 3| 5| 3| 3| 6| 2| 5| 3| 3| | |
| 5| 0| 6| 0| 0| 8| 5| 6| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Trichoepithelioma | X | 1 |
Subcutaneous Tissue, | | |
Neurofibrosarcoma | | 1 |
__________________________________________________________________________|____________|
Skin, Control | | 1 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 5| 7| 4| 7| 7| 6| 7| 4| 7| 7| | |
DAY ON TEST | 6| 3| 5| 3| 3| 6| 2| 5| 3| 3| | |
| 5| 0| 6| 0| 0| 8| 5| 6| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7| 4| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5|
DAY ON TEST | 2| 6| 2| 2| 2| 2| 5| 8| 2| 5| 2| 5| 2| 5| 3| 2| 2| 2| 4| 8| 4| 2| 9| 2| 2|
| 9| 8| 9| 9| 9| 9| 6| 7| 9| 6| 9| 6| 9| 6| 4| 9| 9| 9| 7| 0| 0| 9| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + |
__________________________________________________________________________|
Tongue | +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + |
Adenoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + M + + + + + + + + + + M + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X |
Pars Distalis, Carcinoma | |
Pars Distalis, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7| 4| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5|
DAY ON TEST | 2| 6| 2| 2| 2| 2| 5| 8| 2| 5| 2| 5| 2| 5| 3| 2| 2| 2| 4| 8| 4| 2| 9| 2| 2|
| 9| 8| 9| 9| 9| 9| 6| 7| 9| 6| 9| 6| 9| 6| 4| 9| 9| 9| 7| 0| 0| 9| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
Leukemia Mononuclear | X X |
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + M + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
Fibroadenoma | X X X X X X X|
Fibroadenoma, Multiple | X X X |
Fibroma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Malignant | X |
Subcutaneous Tissue, Lipoma | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandible, Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7| 4| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5|
DAY ON TEST | 2| 6| 2| 2| 2| 2| 5| 8| 2| 5| 2| 5| 2| 5| 3| 2| 2| 2| 4| 8| 4| 2| 9| 2| 2|
| 9| 8| 9| 9| 9| 9| 6| 7| 9| 6| 9| 6| 9| 6| 4| 9| 9| 9| 7| 0| 0| 9| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 5| 6| 7| 4| 6| 6| 3| 7| 7| 7| 6| 4| 4| 7| 3| 5| 5| 6| 5| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 8| 1| 2| 5| 6| 3| 0| 2| 2| 2| 5| 8| 5| 2| 2| 9| 3| 3| 3| 2| 2| 2| 7| 3| 2|
| 7| 9| 9| 6| 7| 2| 3| 9| 9| 9| 8| 6| 6| 9| 2| 4| 3| 4| 7| 3| 9| 9| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.5 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X |
Pars Distalis, Carcinoma | X |
Pars Distalis, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | |
Mediastinal, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 5| 6| 7| 4| 6| 6| 3| 7| 7| 7| 6| 4| 4| 7| 3| 5| 5| 6| 5| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 8| 1| 2| 5| 6| 3| 0| 2| 2| 2| 5| 8| 5| 2| 2| 9| 3| 3| 3| 2| 2| 2| 7| 3| 2|
| 7| 9| 9| 6| 7| 2| 3| 9| 9| 9| 8| 6| 6| 9| 2| 4| 3| 4| 7| 3| 9| 9| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.5 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Leukemia Mononuclear | |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
Fibroadenoma | X X X |
Fibroadenoma, Multiple | X |
Fibroma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Malignant | |
Subcutaneous Tissue, Lipoma | X|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandible, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 5| 6| 7| 4| 6| 6| 3| 7| 7| 7| 6| 4| 4| 7| 3| 5| 5| 6| 5| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 8| 1| 2| 5| 6| 3| 0| 2| 2| 2| 5| 8| 5| 2| 2| 9| 3| 3| 3| 2| 2| 2| 7| 3| 2|
| 7| 9| 9| 6| 7| 2| 3| 9| 9| 9| 8| 6| 6| 9| 2| 4| 3| 4| 7| 3| 9| 9| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.5 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 6| 4| 5| 3| | |
DAY ON TEST | 2| 0| 7| 0| 2| 2| 1| 5| 6| 5| | |
| 9| 3| 7| 0| 9| 9| 3| 6| 2| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.5 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 17 |
__________________________________________________________________________|____________|
Mesentery | | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 8 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 21 |
Adenoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | | 2 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Adenoma | X X X X | 28 |
Pars Distalis, Carcinoma | X | 2 |
Pars Distalis, Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Adenoma | X | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + + + | 59 |
Adenoma | X | 4 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Polyp Stromal | X | 7 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 6| 4| 5| 3| | |
DAY ON TEST | 2| 0| 7| 0| 2| 2| 1| 5| 6| 5| | |
| 9| 3| 7| 0| 9| 9| 3| 6| 2| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.5 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + M + | 59 |
Femoral, Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Mediastinal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 3 |
Leukemia Mononuclear | | 2 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 3 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 18 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Adenoma | | 2 |
Carcinoma | | 1 |
Fibroadenoma | X X | 12 |
Fibroadenoma, Multiple | X | 5 |
Fibroma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Basosquamous Tumor Malignant | | 1 |
Subcutaneous Tissue, Lipoma | | 1 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + | 39 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Mandible, Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 4 |
__________________________________________________________________________|____________|
Spinal Cord | | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 6| 4| 5| 3| | |
DAY ON TEST | 2| 0| 7| 0| 2| 2| 1| 5| 6| 5| | |
| 9| 3| 7| 0| 9| 9| 3| 6| 2| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.5 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|
DAY ON TEST | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|
| 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
Adenoma | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X|
Mesothelioma Malignant | |
__________________________________________________________________________|
Mesentery | + + + + |
Lipoma | |
Mesothelioma Malignant | |
Fat, Histiocytic Sarcoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Pharynx | + |
Palate, Squamous Cell Papilloma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + +|
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
Gingiva, Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + +|
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|
DAY ON TEST | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|
| 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Leukemia Mononuclear | X X X|
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Adenoma, Multiple | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Bilateral, Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Histiocytic Sarcoma | X |
Femoral, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Histiocytic Sarcoma | X |
Mediastinal, Leukemia Mononuclear | X X |
Renal, Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + |
Hemangiosarcoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + M M + + M + + + + + + + M|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|
DAY ON TEST | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|
| 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + M + + + M + + + + + + + + + +|
Adenoma | X |
Fibroadenoma | X |
Fibroma | X |
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Keratoacanthoma | |
Squamous Cell Papilloma | |
Sebaceous Gland, Lip, Carcinoma | |
Subcutaneous Tissue, Neurofibroma | |
__________________________________________________________________________|
Skin, Control | + |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + |
__________________________________________________________________________|
Skin, Site of Application-Mass | + |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
__________________________________________________________________________|
Skin, Site of Application-Mass | + |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|
DAY ON TEST | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|
| 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|
DAY ON TEST | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|
| 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
Adenoma | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Mesentery | + + |
Lipoma | |
Mesothelioma Malignant | X |
Fat, Histiocytic Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pharynx | |
Palate, Squamous Cell Papilloma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
Gingiva, Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + +|
Pheochromocytoma Benign | |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + M +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|
DAY ON TEST | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|
| 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Leukemia Mononuclear | X X|
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
C-Cell, Adenoma | X X X |
C-Cell, Adenoma, Multiple | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Bilateral, Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Histiocytic Sarcoma | |
Femoral, Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Lymph Node | + + +|
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Leukemia Mononuclear | X X X|
Renal, Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + +|
Hemangiosarcoma | |
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + M + + + + + + + M +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|
DAY ON TEST | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|
| 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Fibroadenoma | |
Fibroma | |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Keratoacanthoma | X |
Squamous Cell Papilloma | X |
Sebaceous Gland, Lip, Carcinoma | |
Subcutaneous Tissue, Neurofibroma | X |
__________________________________________________________________________|
Skin, Control | + + |
__________________________________________________________________________|
Skin, Site of Application-No Mass | +|
__________________________________________________________________________|
Skin, Site of Application-Mass | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | +|
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
__________________________________________________________________________|
Skin, Site of Application-Mass | |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + |
__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + M +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
Squamous Cell Papilloma | X X |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|
DAY ON TEST | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|
| 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 5| 4| 6| 7| 5| | |
DAY ON TEST | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6| | |
| 1| 1| 4| 5| 8| 3| 6| 7| 6| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 2 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X | 22 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Lipoma | X | 1 |
Mesothelioma Malignant | | 1 |
Fat, Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 10 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 13 |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
Gingiva, Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 29 |
Adenoma | X | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 27 |
Pheochromocytoma Benign | X X | 3 |
Bilateral, Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 5| 4| 6| 7| 5| | |
DAY ON TEST | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6| | |
| 1| 1| 4| 5| 8| 3| 6| 7| 6| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 58 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Adenoma | X X X X | 34 |
Pars Distalis, Leukemia Mononuclear | X X | 7 |
Pars Intermedia, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Adenoma | X | 6 |
C-Cell, Adenoma, Multiple | X | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Serosa, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Carcinoma | | 1 |
Bilateral, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Bilateral, Interstitial Cell, Adenoma| X X X X X | 24 |
Interstitial Cell, Adenoma | X X X | 21 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Femoral, Histiocytic Sarcoma | | 1 |
Femoral, Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Lymph Node | + | 8 |
Mediastinal, Histiocytic Sarcoma | | 1 |
Mediastinal, Leukemia Mononuclear | X | 6 |
Renal, Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 13 |
Hemangiosarcoma | | 1 |
Leukemia Mononuclear | X X X | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 5| 4| 6| 7| 5| | |
DAY ON TEST | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6| | |
| 1| 1| 4| 5| 8| 3| 6| 7| 6| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 9 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | X | 2 |
Leukemia Mononuclear | X X X X | 23 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 52 |
Leukemia Mononuclear | | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + | 55 |
Adenoma | | 1 |
Fibroadenoma | | 1 |
Fibroma | X X | 3 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Keratoacanthoma | | 1 |
Squamous Cell Papilloma | | 1 |
Sebaceous Gland, Lip, Carcinoma | X | 1 |
Subcutaneous Tissue, Neurofibroma | | 1 |
__________________________________________________________________________|____________|
Skin, Control | | 3 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | | 2 |
__________________________________________________________________________|____________|
Skin, Site of Application-Mass | + + + | 5 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | | 2 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Skin, Site of Application-Mass | + + + | 5 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Maxilla, Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 5 |
__________________________________________________________________________|____________|
Spinal Cord | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 5| 4| 6| 7| 5| | |
DAY ON TEST | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6| | |
| 1| 1| 4| 5| 8| 3| 6| 7| 6| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
Squamous Cell Papilloma | | 3 |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Transitional Epithelium, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | X | 3 |
Leukemia Mononuclear | X X X X | 23 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 5| 4| 5| 7| 3| 5| 2| 7| 6| 4| 7| 7| 6| 4| 6| 4| 6| 6| 4| 6| 7| 5| 6| 5| 4|
DAY ON TEST | 6| 6| 7| 3| 7| 4| 6| 1| 9| 5| 3| 3| 9| 5| 3| 5| 1| 3| 5| 3| 3| 9| 7| 4| 5|
| 4| 1| 9| 0| 9| 1| 4| 0| 1| 7| 0| 0| 8| 6| 8| 6| 2| 2| 6| 9| 0| 1| 0| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
.15 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | X |
__________________________________________________________________________|
Skin, Control | + + |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 5| 4| 5| 7| 3| 5| 2| 7| 6| 4| 7| 7| 6| 4| 6| 4| 6| 6| 4| 6| 7| 5| 6| 5| 4|
DAY ON TEST | 6| 6| 7| 3| 7| 4| 6| 1| 9| 5| 3| 3| 9| 5| 3| 5| 1| 3| 5| 3| 3| 9| 7| 4| 5|
| 4| 1| 9| 0| 9| 1| 4| 0| 1| 7| 0| 0| 8| 6| 8| 6| 2| 2| 6| 9| 0| 1| 0| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
.15 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 7| 4| 4| 6| 6| 5| 4| 4| 5| 7| 5| 6| 7| 6| 4| 7| 6| 7| 6| 7| 6| 7| 6| 5| 6|
DAY ON TEST | 2| 5| 7| 7| 2| 9| 5| 9| 7| 2| 7| 0| 3| 6| 5| 3| 9| 3| 7| 3| 5| 3| 5| 5| 2|
| 3| 6| 9| 5| 6| 3| 6| 9| 8| 2| 6| 6| 0| 8| 6| 0| 8| 1| 1| 1| 9| 1| 9| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.15 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
__________________________________________________________________________|
Skin, Control | + |
__________________________________________________________________________|
Skin, Site of Application-No Mass | |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 7| 4| 4| 6| 6| 5| 4| 4| 5| 7| 5| 6| 7| 6| 4| 7| 6| 7| 6| 7| 6| 7| 6| 5| 6|
DAY ON TEST | 2| 5| 7| 7| 2| 9| 5| 9| 7| 2| 7| 0| 3| 6| 5| 3| 9| 3| 7| 3| 5| 3| 5| 5| 2|
| 3| 6| 9| 5| 6| 3| 6| 9| 8| 2| 6| 6| 0| 8| 6| 0| 8| 1| 1| 1| 9| 1| 9| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.15 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 5| 6| 4| 6| | |
DAY ON TEST | 3| 2| 3| 1| 1| 1| 5| 1| 5| 2| | |
| 1| 1| 1| 2| 0| 2| 6| 6| 6| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
.15 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | | 1 |
__________________________________________________________________________|____________|
Skin, Control | | 3 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | | 1 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 5| 6| 4| 6| | |
DAY ON TEST | 3| 2| 3| 1| 1| 1| 5| 1| 5| 2| | |
| 1| 1| 1| 2| 0| 2| 6| 6| 6| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
.15 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 6| 4| 6| 7| 5| 5| 6| 4| 4| 6| 7| 6| 6| 5| 3| 7| 4| 6| 6| 4|
DAY ON TEST | 5| 0| 6| 8| 0| 4| 1| 7| 2| 2| 9| 6| 3| 5| 4| 1| 3| 9| 1| 6| 2| 5| 5| 4| 8|
| 6| 0| 4| 2| 7| 3| 6| 6| 9| 3| 9| 6| 7| 6| 8| 8| 2| 6| 1| 7| 9| 6| 5| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
Basosquamous Tumor Benign | |
Keratoacanthoma | X |
Subcutaneous Tissue, Fibroma | X |
__________________________________________________________________________|
Skin, Control | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + |
__________________________________________________________________________|
Skin, Site of Application-Mass | + |
Keratoacanthoma | |
Sebaceous Gland, Carcinoma | X |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + |
__________________________________________________________________________|
Skin, Site of Application-Mass | + |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 6| 4| 6| 7| 5| 5| 6| 4| 4| 6| 7| 6| 6| 5| 3| 7| 4| 6| 6| 4|
DAY ON TEST | 5| 0| 6| 8| 0| 4| 1| 7| 2| 2| 9| 6| 3| 5| 4| 1| 3| 9| 1| 6| 2| 5| 5| 4| 8|
| 6| 0| 4| 2| 7| 3| 6| 6| 9| 3| 9| 6| 7| 6| 8| 8| 2| 6| 1| 7| 9| 6| 5| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 5| 4| 4| 5| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6| 0| 5| 7| 5| 6| 1| 6| 6| 6| 7| 7|
DAY ON TEST | 8| 5| 5| 8| 2| 2| 3| 3| 6| 7| 0| 2| 2| 1| 2| 3| 2| 2| 8| 9| 2| 0| 9| 2| 1|
| 7| 6| 6| 9| 9| 9| 5| 5| 2| 1| 5| 6| 7| 3| 5| 7| 9| 6| 3| 9| 1| 1| 8| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Basosquamous Tumor Benign | X |
Keratoacanthoma | |
Subcutaneous Tissue, Fibroma | |
__________________________________________________________________________|
Skin, Control | + |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + |
__________________________________________________________________________|
Skin, Site of Application-Mass | |
Keratoacanthoma | |
Sebaceous Gland, Carcinoma | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + |
__________________________________________________________________________|
Skin, Site of Application-Mass | |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 5| 4| 4| 5| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6| 0| 5| 7| 5| 6| 1| 6| 6| 6| 7| 7|
DAY ON TEST | 8| 5| 5| 8| 2| 2| 3| 3| 6| 7| 0| 2| 2| 1| 2| 3| 2| 2| 8| 9| 2| 0| 9| 2| 1|
| 7| 6| 6| 9| 9| 9| 5| 5| 2| 1| 5| 6| 7| 3| 5| 7| 9| 6| 3| 9| 1| 1| 8| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 6| 7| 5| 7| 7| 6| 6| | |
DAY ON TEST | 5| 3| 5| 6| 3| 7| 3| 3| 5| 1| | |
| 8| 2| 6| 3| 0| 5| 0| 0| 8| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.5 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Basal Cell Adenoma | | 1 |
Basosquamous Tumor Benign | | 1 |
Keratoacanthoma | X X | 3 |
Subcutaneous Tissue, Fibroma | | 1 |
__________________________________________________________________________|____________|
Skin, Control | + | 2 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + | 8 |
__________________________________________________________________________|____________|
Skin, Site of Application-Mass | + | 3 |
Keratoacanthoma | X | 1 |
Sebaceous Gland, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + | 8 |
__________________________________________________________________________|____________|
Skin, Site of Application-Mass | + | 3 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 6| 7| 5| 7| 7| 6| 6| | |
DAY ON TEST | 5| 3| 5| 6| 3| 7| 3| 3| 5| 1| | |
| 8| 2| 6| 3| 0| 5| 0| 0| 8| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.5 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|
DAY ON TEST | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|
| 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + |
Adenoma | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
Adenocarcinoma | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + |
Squamous Cell Carcinoma, Metastatic, | |
Lung | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
Bilateral, Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X|
Pars Distalis, Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X X X X X|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|
DAY ON TEST | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|
| 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Mesothelioma Benign | X |
Serosa, Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Axillary, Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | X X |
Inguinal, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X X X X X X X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
Thoracic, Squamous Cell Carcinoma, | |
Metastatic, Lung | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + M + + + M + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Lung | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + M + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|
DAY ON TEST | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|
| 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibroadenoma | X X |
Fibroma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
__________________________________________________________________________|
Skin, Control | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + |
__________________________________________________________________________|
Skin, Site of Application-Mass | + |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + |
__________________________________________________________________________|
Skin, Site of Application-Mass | + |
Keratoacanthoma | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + |
__________________________________________________________________________|
Skin, Site of Application-Mass | + |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | |
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Transitional Epithelium, Papilloma | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|
DAY ON TEST | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|
| 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X|
Mesothelioma Benign | X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|
DAY ON TEST | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|
| 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.5 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | |
Adenoma | |
__________________________________________________________________________|
Intestine Small, Duodenum | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
Adenocarcinoma | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + |
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + |
Squamous Cell Carcinoma, Metastatic, | |
Lung | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X |
Bilateral, Pheochromocytoma Benign | X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X |
Pars Distalis, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X X X |
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|
DAY ON TEST | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|
| 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.5 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Mesothelioma Benign | |
Serosa, Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + + |
Axillary, Leukemia Mononuclear | X |
Deep Cervical, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X |
Thoracic, Squamous Cell Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + M|
Leukemia Mononuclear | |
Squamous Cell Carcinoma, Metastatic, | |
Lung | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + M + + M + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|
DAY ON TEST | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|
| 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.5 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibroadenoma | X |
Fibroma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
__________________________________________________________________________|
Skin, Control | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + |
__________________________________________________________________________|
Skin, Site of Application-Mass | + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + |
__________________________________________________________________________|
Skin, Site of Application-Mass | + +|
Keratoacanthoma | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + |
__________________________________________________________________________|
Skin, Site of Application-Mass | + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Transitional Epithelium, Papilloma | X |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
_____________________________________________________________________________________________________________________
| 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|
DAY ON TEST | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|
| 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.5 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Leukemia Mononuclear | X X X X X X X X X X |
Mesothelioma Benign | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 4| 3| 6| 7| 4| | |
DAY ON TEST | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2| | |
| 9| 9| 5| 4| 9| 6| 6| 0| 9| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.5 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 1 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 3 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 1 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X X X X X | 30 |
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 13 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 11 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 24 |
Squamous Cell Carcinoma, Metastatic, | | |
Lung | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 29 |
Leukemia Mononuclear | | 2 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X | 4 |
Bilateral, Pheochromocytoma Benign | | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Adenoma | X | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + | 58 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X | 25 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 4| 3| 6| 7| 4| | |
DAY ON TEST | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2| | |
| 9| 9| 5| 4| 9| 6| 6| 0| 9| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.5 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Leukemia Mononuclear | X | 7 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | X | 9 |
Follicular Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Serosa, Mesothelioma Benign | | 1 |
Serosa, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Adenoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X | 30 |
Interstitial Cell, Adenoma | | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Femoral, Leukemia Mononuclear | X X | 10 |
__________________________________________________________________________|____________|
Lymph Node | | 14 |
Axillary, Leukemia Mononuclear | | 1 |
Deep Cervical, Leukemia Mononuclear | | 2 |
Inguinal, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 11 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 2 |
Thoracic, Squamous Cell Carcinoma, | | |
Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 17 |
Leukemia Mononuclear | X X | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 4| 3| 6| 7| 4| | |
DAY ON TEST | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2| | |
| 9| 9| 5| 4| 9| 6| 6| 0| 9| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.5 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 14 |
Leukemia Mononuclear | X | 12 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X | 29 |
__________________________________________________________________________|____________|
Thymus | + M + + M + M + M + | 51 |
Leukemia Mononuclear | | 7 |
Squamous Cell Carcinoma, Metastatic, | | |
Lung | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 53 |
Fibroadenoma | | 3 |
Fibroma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Skin, Control | + | 1 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + | 16 |
__________________________________________________________________________|____________|
Skin, Site of Application-Mass | + | 4 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + | 16 |
__________________________________________________________________________|____________|
Skin, Site of Application-Mass | + | 4 |
Keratoacanthoma | X | 1 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + | 16 |
__________________________________________________________________________|____________|
Skin, Site of Application-Mass | + | 4 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + | 16 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Astrocytoma NOS | X | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05102-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/01/97
Route: DERMAL,SOLUTION Time: 16:16:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 4| 3| 6| 7| 4| | |
DAY ON TEST | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2| | |
| 9| 9| 5| 4| 9| 6| 6| 0| 9| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.5 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X | 15 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + M | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 2 |
Transitional Epithelium, Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 3 |
Leukemia Mononuclear | X X X X X X X | 30 |
Mesothelioma Benign | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
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---------- END OF REPORT ----------
------------------------------------------------------------