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TDMS Study 05102-05 Pathology Tables

NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  121-54-0

       Lock Date:  01/24/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 5| 4| 6| 4| 5| 7| 7| 4| 7| 7| 1| 7| 6| 4| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 4| 3| 3| 3| 7| 5| 9| 5| 1| 3| 2| 5| 3| 3| 7| 3| 4| 5| 1| 4| 4| 3| 3|             
                                           | 1| 4| 8| 1| 1| 1| 2| 6| 6| 6| 9| 1| 4| 6| 1| 1| 6| 1| 9| 6| 0| 4| 2| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                          |             
      Peyer's Patch, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X     X  X        X        X                          X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                             +                                 |             
      Fat, Liposarcoma                     |                                        X                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +                          +                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +     +  +                          +        +              +   |             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |       +        +                                                         |             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |                X                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X     X     X  X     X     X  X        X           X                  |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Carcinoma             |                                     X                                    |             
      Pars Distalis, Leukemia Mononuclear  |    X  X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                   X              X                                   X   |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                   X                       X              X               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 5| 4| 6| 4| 5| 7| 7| 4| 7| 7| 1| 7| 6| 4| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 4| 3| 3| 3| 7| 5| 9| 5| 1| 3| 2| 5| 3| 3| 7| 3| 4| 5| 1| 4| 4| 3| 3|             
                                           | 1| 4| 8| 1| 1| 1| 2| 6| 6| 6| 9| 1| 4| 6| 1| 1| 6| 1| 9| 6| 0| 4| 2| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |          X                                                               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                             +            |             
      Mediastinal, Leukemia Mononuclear    |                                                             X            |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +                                                     +            |             
      Leukemia Mononuclear                 |    X                                                        X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                             +            |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X        X        X        X                          X            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                                     X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |       X                                                                  |             
      Adenoma, Multiple                    |                                     X                                    |             
      Fibroadenoma                         |             X     X                                   X                  |             
      Fibroadenoma, Multiple               |                                  X                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Benign            |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                        X                                 |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 5| 4| 6| 4| 5| 7| 7| 4| 7| 7| 1| 7| 6| 4| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 4| 3| 3| 3| 7| 5| 9| 5| 1| 3| 2| 5| 3| 3| 7| 3| 4| 5| 1| 4| 4| 3| 3|             
                                           | 1| 4| 8| 1| 1| 1| 2| 6| 6| 6| 9| 1| 4| 6| 1| 1| 6| 1| 9| 6| 0| 4| 2| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |    X  X                                                     X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nares, Squamous Cell Papilloma       |                                                                          |             
      Vomeronasal Organ, Squamous Cell     |                                                                          |             
          Carcinoma                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                       +     +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X     X  X        X        X                          X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 6| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 5| 3| 3| 3| 3| 5| 2| 3| 8| 9| 3| 3| 4| 3| 2| 3| 6| 1| 3| 3| 3| 5| 3| 3|             
                                           | 6| 6| 1| 1| 3| 1| 4| 0| 1| 5| 5| 1| 1| 5| 1| 6| 1| 7| 9| 1| 1| 1| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                       +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +                                                            |             
      Peyer's Patch, Leukemia Mononuclear  |             X                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X        X  X  X                       X  X        X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +        +                                          |             
      Fat, Liposarcoma                     |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                          X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                            +        +                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |             +  +           +                    +     +                  |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |             +                                   +     +  +  +        +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
      Pheochromocytoma Benign              |                                                 X        X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                X  X              X  X  X  X  X  X  X     X  X  X  X  X  X|             
      Pars Distalis, Adenoma, Multiple     |          X                                                               |             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |             X        X                                X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                           X                              |             
      C-Cell, Adenoma                      |                      X                             X  X     X        X  X|             
      C-Cell, Carcinoma                    |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                             X            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 6| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 5| 3| 3| 3| 3| 5| 2| 3| 8| 9| 3| 3| 4| 3| 2| 3| 6| 1| 3| 3| 3| 5| 3| 3|             
                                           | 6| 6| 1| 1| 3| 1| 4| 0| 1| 5| 5| 1| 1| 5| 1| 6| 1| 7| 9| 1| 1| 1| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |                         X  X                                             |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                      X     X                       X                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +  +                          +                  |             
      Mediastinal, Leukemia Mononuclear    |                         X  X                                             |             
      Pancreatic, Leukemia Mononuclear     |                            X                          X                  |             
      Renal, Leukemia Mononuclear          |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +              +                                             |             
      Leukemia Mononuclear                 |             X              X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +              +                                             |             
      Leukemia Mononuclear                 |             X              X                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X        X  X  X                       X  X        X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                 X                        |             
      Adenoma, Multiple                    |                                                                          |             
      Fibroadenoma                         |          X           X           X  X           X     X        X         |             
      Fibroadenoma, Multiple               |                X                                                        X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Benign            |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 6| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 5| 3| 3| 3| 3| 5| 2| 3| 8| 9| 3| 3| 4| 3| 2| 3| 6| 1| 3| 3| 3| 5| 3| 3|             
                                           | 6| 6| 1| 1| 3| 1| 4| 0| 1| 5| 5| 1| 1| 5| 1| 6| 1| 7| 9| 1| 1| 1| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                      X   |             
      Leukemia Mononuclear                 |             X        X  X  X                          X                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nares, Squamous Cell Papilloma       |                                        X                                 |             
      Vomeronasal Organ, Squamous Cell     |                                                                          |             
          Carcinoma                        |                               X                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +     +                                         +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X        X  X  X                       X  X        X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 6| 7| 6| 5| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 1| 5| 3| 0| 2| 4| 1| 5| 0| 1|                                            |            |
                                           | 8| 6| 1| 3| 2| 2| 5| 6| 9| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     A      |
    0 MG/KG                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   1        |
      Peyer's Patch, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X                       X  X                                             |         18 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fat, Liposarcoma                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +                                                               |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +        +  +           +  +                                             |  19        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                            +                                             |  10        |
      Leukemia Mononuclear                 |                            X                                             |          2 |
      Pheochromocytoma Benign              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  M                                             |  56        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Adenoma               |             X  X  X     X                                                |         28 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          1 |
      Pars Distalis, Carcinoma             |       X                                                                  |          2 |
      Pars Distalis, Leukemia Mononuclear  | X                          X                                             |          7 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |                   X                                                      |         10 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 6| 7| 6| 5| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 1| 5| 3| 0| 2| 4| 1| 5| 0| 1|                                            |            |
                                           | 8| 6| 1| 3| 2| 2| 5| 6| 9| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     A      |
    0 MG/KG                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +                                             |  59        |
      Adenoma                              |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Polyp Stromal                        |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femoral, Leukemia Mononuclear        | X                          X                                             |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                            +                                             |   5        |
      Mediastinal, Leukemia Mononuclear    |                            X                                             |          4 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                          +                                             |   7        |
      Leukemia Mononuclear                 | X                          X                                             |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                          +                                             |   5        |
      Leukemia Mononuclear                 | X                          X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X                       X  X                                             |         17 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  M  +                                             |  54        |
      Leukemia Mononuclear                 | X                                                                        |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |                                                                          |          2 |
      Adenoma, Multiple                    |                                                                          |          1 |
      Fibroadenoma                         | X     X     X           X                                                |         14 |
      Fibroadenoma, Multiple               |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basosquamous Tumor Benign            |             X                                                            |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |                         +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 6| 7| 6| 5| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 1| 5| 3| 0| 2| 4| 1| 5| 0| 1|                                            |            |
                                           | 8| 6| 1| 3| 2| 2| 5| 6| 9| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     A      |
    0 MG/KG                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Leukemia Mononuclear                 | X                          X                                             |         10 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Nares, Squamous Cell Papilloma       |                                                                          |          1 |
      Vomeronasal Organ, Squamous Cell     |                                                                          |            |
          Carcinoma                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                            X                                             |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X                       X  X                                             |         18 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 5| 0| 5| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3|             
                                           | 0| 1| 2| 6| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 9| 6| 0| 0| 6| 8| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .15                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |             +                                                        +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 4| 7| 7| 7| 3| 7| 7| 4| 7| 3| 6| 6| 7| 6| 5| 7| 4| 6| 7| 7| 4| 6| 4|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 9| 3| 3| 5| 3| 6| 1| 3| 3| 8| 8| 3| 5| 1| 3| 3| 5| 7| 5|             
                                           | 8| 0| 6| 0| 0| 0| 3| 0| 0| 6| 0| 6| 2| 3| 0| 0| 2| 0| 6| 2| 0| 1| 6| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .15                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                             +            |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 8| 3| 3| 3| 3| 1|                                            |            |
                                           | 1| 1| 7| 1| 4| 1| 1| 1| 1| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    .15                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skin, Control                           |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 5| 7| 4| 6| 4| 5| 4| 6| 4| 7| 6| 2| 7| 6| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 7| 4| 2| 2| 7| 2| 5| 8| 5| 3| 5| 7| 5| 2| 3| 9| 0| 1| 2| 2| 2| 3| 0| 1| 3|             
                                           | 9| 9| 9| 9| 9| 9| 6| 6| 6| 3| 6| 8| 6| 9| 2| 7| 8| 0| 9| 9| 9| 0| 6| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Trichoepithelioma                    |                                                                          |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |       +                 +        +              +                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 4| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 4| 4| 6| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 5| 5| 8| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 9| 6| 8| 3| 3| 3| 7| 2| 0|             
                                           | 0| 6| 6| 6| 1| 0| 0| 0| 0| 0| 8| 0| 0| 4| 8| 0| 2| 5| 5| 0| 0| 0| 9| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Trichoepithelioma                    |                                                                          |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                          X               |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                                +         |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +                                         +           +               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 4| 7| 7| 6| 7| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 3| 5| 3| 3| 6| 2| 5| 3| 3|                                            |            |
                                           | 5| 0| 6| 0| 0| 8| 5| 6| 0| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.5                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Trichoepithelioma                    |          X                                                               |          1 |
      Subcutaneous Tissue,                 |                                                                          |            |
          Neurofibrosarcoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin, Control                           |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |                            +                                             |   8        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 4| 7| 7| 6| 7| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 3| 5| 3| 3| 6| 2| 5| 3| 3|                                            |            |
                                           | 5| 0| 6| 0| 0| 8| 5| 6| 0| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.5                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7| 4| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 6| 2| 2| 2| 2| 5| 8| 2| 5| 2| 5| 2| 5| 3| 2| 2| 2| 4| 8| 4| 2| 9| 2| 2|             
                                           | 9| 8| 9| 9| 9| 9| 6| 7| 9| 6| 9| 6| 9| 6| 4| 9| 9| 9| 7| 0| 0| 9| 9| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X     X     X                    X  X              X  X  X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                      +                                +     +            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +     +  +                 +                 +  +         |             
      Adenoma                              |                                           X                              |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |                                           +                              |             
      Bilateral, Pheochromocytoma Benign   |                                           X                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X  X     X  X  X     X                    X        X        X  X  X   |             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                      X                    X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                    X                 X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                X         |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                      X                    X                 X            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +                                                         |             
      Mediastinal, Leukemia Mononuclear    |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7| 4| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 6| 2| 2| 2| 2| 5| 8| 2| 5| 2| 5| 2| 5| 3| 2| 2| 2| 4| 8| 4| 2| 9| 2| 2|             
                                           | 9| 8| 9| 9| 9| 9| 6| 7| 9| 6| 9| 6| 9| 6| 4| 9| 9| 9| 7| 0| 0| 9| 9| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +     +                                   +               |             
      Leukemia Mononuclear                 |                X     X                                                   |             
      Osteosarcoma, Metastatic, Bone       |                                                          X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                         +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X     X     X                    X  X  X           X  X  X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                              X                           |             
      Fibroadenoma                         |          X  X  X                                X     X        X        X|             
      Fibroadenoma, Multiple               |       X                 X                                            X   |             
      Fibroma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Malignant         |                                     X                                    |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +     +  +  +  +  +  +  +  +     +     +  +  +     +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandible, Osteosarcoma               |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                      +                    +                              |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                    +                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X     X                                            X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +  +                                         +      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7| 4| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 6| 2| 2| 2| 2| 5| 8| 2| 5| 2| 5| 2| 5| 3| 2| 2| 2| 4| 8| 4| 2| 9| 2| 2|             
                                           | 9| 8| 9| 9| 9| 9| 6| 7| 9| 6| 9| 6| 9| 6| 4| 9| 9| 9| 7| 0| 0| 9| 9| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X     X     X                    X  X  X           X  X  X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 4| 6| 6| 3| 7| 7| 7| 6| 4| 4| 7| 3| 5| 5| 6| 5| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 8| 1| 2| 5| 6| 3| 0| 2| 2| 2| 5| 8| 5| 2| 2| 9| 3| 3| 3| 2| 2| 2| 7| 3| 2|             
                                           | 7| 9| 9| 6| 7| 2| 3| 9| 9| 9| 8| 6| 6| 9| 2| 4| 3| 4| 7| 3| 9| 9| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.5                                    | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X           X     X     X        X                 X     X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                  +  +            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +              +                                         +        +  +   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +     +              +  +  +                    +  +     +  +           +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |                         +                                                |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X        X  X     X     X  X  X                 X  X           X  X   |             
      Pars Distalis, Carcinoma             |                                                          X               |             
      Pars Distalis, Leukemia Mononuclear  |                   X     X                                      X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                            X                                X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                 X                                 |             
      Carcinoma                            |                         X                                      X         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        | X                    X                 X        X     X                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                                                          X               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 4| 6| 6| 3| 7| 7| 7| 6| 4| 4| 7| 3| 5| 5| 6| 5| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 8| 1| 2| 5| 6| 3| 0| 2| 2| 2| 5| 8| 5| 2| 2| 9| 3| 3| 3| 2| 2| 2| 7| 3| 2|             
                                           | 7| 9| 9| 6| 7| 2| 3| 9| 9| 9| 8| 6| 6| 9| 2| 4| 3| 4| 7| 3| 9| 9| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.5                                    | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +                                          |             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X           X     X     X        X                 X     X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                         X     X                                          |             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         |    X                    X                       X                        |             
      Fibroadenoma, Multiple               |       X                                                                  |             
      Fibroma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Malignant         |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                         X|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +     +     +  +           +  +        +  +     +  +  +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandible, Osteosarcoma               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                          X               |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +              +                                                         |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +              +                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                 X           X                          X               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 4| 6| 6| 3| 7| 7| 7| 6| 4| 4| 7| 3| 5| 5| 6| 5| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 8| 1| 2| 5| 6| 3| 0| 2| 2| 2| 5| 8| 5| 2| 2| 9| 3| 3| 3| 2| 2| 2| 7| 3| 2|             
                                           | 7| 9| 9| 6| 7| 2| 3| 9| 9| 9| 8| 6| 6| 9| 2| 4| 3| 4| 7| 3| 9| 9| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.5                                    | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X           X     X     X        X                 X     X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 6| 4| 5| 3|                                            |            |
                             DAY ON TEST   | 2| 0| 7| 0| 2| 2| 1| 5| 6| 5|                                            |            |
                                           | 9| 3| 7| 0| 9| 9| 3| 6| 2| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    1.5                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |         17 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |   8        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |             +                                                            |  21        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                                                                          |   2        |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Adenoma               | X  X     X        X                                                      |         28 |
      Pars Distalis, Carcinoma             |                         X                                                |          2 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Adenoma                      |                   X                                                      |          5 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  +                                             |  59        |
      Adenoma                              | X                                                                        |          4 |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Polyp Stromal                        | X                                                                        |          7 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 6| 4| 5| 3|                                            |            |
                             DAY ON TEST   | 2| 0| 7| 0| 2| 2| 1| 5| 6| 5|                                            |            |
                                           | 9| 3| 7| 0| 9| 9| 3| 6| 2| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    1.5                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  M  +                                             |  59        |
      Femoral, Leukemia Mononuclear        |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |   3        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                                      |   3        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |         18 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          1 |
      Fibroadenoma                         |       X        X                                                         |         12 |
      Fibroadenoma, Multiple               | X                                                                        |          5 |
      Fibroma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basosquamous Tumor Malignant         |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |    +     +     +  +  +  +                                                |  39        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mandible, Osteosarcoma               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                         X                                                |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 6| 4| 5| 3|                                            |            |
                             DAY ON TEST   | 2| 0| 7| 0| 2| 2| 1| 5| 6| 5|                                            |            |
                                           | 9| 3| 7| 0| 9| 9| 3| 6| 2| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    1.5                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |         18 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|             
                                           | 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                        +                                 |             
      Adenoma                              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                X                                                         |             
      Leukemia Mononuclear                 |    X        X              X  X     X  X           X  X  X        X     X|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +           +                       +  +                  |             
      Lipoma                               |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Fat, Histiocytic Sarcoma             |                X                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                          +               |             
      Palate, Squamous Cell Papilloma      |                                                          X               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +                 +              +  +              +     +   |             
      Squamous Cell Papilloma              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +                                      +              +     +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                               +                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                               +                                          |             
      Gingiva, Squamous Cell Carcinoma     |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +                 +     +        +  +  +     +  +  +     +     +  +     +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +        +        +  +  +     +           +     +     +              +|             
      Pheochromocytoma Benign              |                                  X                                       |             
      Bilateral, Pheochromocytoma Benign   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X  X  X        X  X           X  X        X  X  X  X     X  X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|             
                                           | 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |             X                          X                                X|             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                 X                 X      |             
      C-Cell, Adenoma, Multiple            |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Mesothelioma Malignant       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Bilateral, Carcinoma                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|    X                 X  X  X  X  X                                X  X   |             
      Interstitial Cell, Adenoma           | X           X  X                       X        X  X  X  X  X  X        X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Femoral, Histiocytic Sarcoma         |                X                                                         |             
      Femoral, Leukemia Mononuclear        |             X              X  X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +                                   +        +            |             
      Mediastinal, Histiocytic Sarcoma     |                X                                                         |             
      Mediastinal, Leukemia Mononuclear    |    X                                               X                     |             
      Renal, Histiocytic Sarcoma           |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +                    +     +        +           +     +               |             
      Hemangiosarcoma                      |                                                          X               |             
      Leukemia Mononuclear                 |    X                          X        X           X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +                    +                             +               |             
      Leukemia Mononuclear                 |    X                       X                             X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |    X        X              X  X     X  X           X  X  X        X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |             X                                      X     X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|             
                                           | 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                 X                        |             
      Fibroadenoma                         |                                     X                                    |             
      Fibroma                              |                                                                   X      |             
      Histiocytic Sarcoma                  |                X                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                X                                                         |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Sebaceous Gland, Lip, Carcinoma      |                                                                          |             
      Subcutaneous Tissue, Neurofibroma    |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                                   +      |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                +                                                         |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                            +                                             |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                +                                                         |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                X                                                         |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                            +                                             |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Maxilla, Osteosarcoma                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |             +                                +                           |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                X                                                         |             
      Leukemia Mononuclear                 |    X        X                                                           X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +      |             
      Squamous Cell Papilloma              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
      Carcinoma                            |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|             
                                           | 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Carcinoma   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                X                                                         |             
      Leukemia Mononuclear                 |    X        X              X  X     X  X           X  X  X        X     X|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|             
                             DAY ON TEST   | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|             
                                           | 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +                                          |             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                        +                                 |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                      X        X  X           X           X        X     X|             
      Mesothelioma Malignant               |                                                                X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                +         |             
      Lipoma                               |                                                                          |             
      Mesothelioma Malignant               |                                                                X         |             
      Fat, Histiocytic Sarcoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Squamous Cell Papilloma      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +                                +                    +               |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +        +           +     +           +           +     +         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Gingiva, Squamous Cell Carcinoma     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                +         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +     +           +  +  +  +  +           +              +  +     +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |       +        +     +  +  +     +  +           +        +           +  +|             
      Pheochromocytoma Benign              |                                                                          |             
      Bilateral, Pheochromocytoma Benign   |                      X                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X     X     X  X  X  X  X  X     X  X     X     X  X  X     X     X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|             
                             DAY ON TEST   | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|             
                                           | 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                               X                                         X|             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      C-Cell, Adenoma                      | X                                               X  X                     |             
      C-Cell, Adenoma, Multiple            |                                                                          |             
      Follicular Cell, Adenoma             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Mesothelioma Malignant       |                                                                X         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                             X            |             
      Bilateral, Carcinoma                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|    X  X                    X              X     X  X  X  X     X  X  X   |             
      Interstitial Cell, Adenoma           | X           X  X     X           X  X                                   X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Histiocytic Sarcoma         |                                                                          |             
      Femoral, Leukemia Mononuclear        |                               X              X                          X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +              +                          +|             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                               X              X                          X|             
      Renal, Histiocytic Sarcoma           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                               +  +                                   +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia Mononuclear                 |                               X  X                                   X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +  +                                      +|             
      Leukemia Mononuclear                 |                               X  X                                      X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                         X|             
      Histiocytic Sarcoma                  |                                              X                           |             
      Leukemia Mononuclear                 |                      X        X  X           X           X        X  X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                               X                          X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|             
                             DAY ON TEST   | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|             
                                           | 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |                                                                          |             
      Fibroma                              |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Keratoacanthoma                      |                            X                                             |             
      Squamous Cell Papilloma              |                                     X                                    |             
      Sebaceous Gland, Lip, Carcinoma      |                                                                          |             
      Subcutaneous Tissue, Neurofibroma    |                            X                                             |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +                                +                                       |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                                                                         +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                                                                         +|             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                                          |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Maxilla, Osteosarcoma                |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |       +                       +                          +               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                       +                          +               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                               X  X           X                          X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +        +                     |             
      Squamous Cell Papilloma              |                                           X        X                     |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +                                             |             
      Carcinoma                            |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|             
                             DAY ON TEST   | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|             
                                           | 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Carcinoma   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                              X                           |             
      Leukemia Mononuclear                 |                      X        X  X           X           X        X  X  X|             
      Mesothelioma Malignant               |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 6| 5| 4| 6| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6|                                            |            |
                                           | 1| 1| 4| 5| 8| 3| 6| 7| 6| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   2        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X     X        X                                                |         22 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                 +                                                   |   8        |
      Lipoma                               |                      X                                                   |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Fat, Histiocytic Sarcoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Squamous Cell Papilloma      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  10        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                         +                                                |  13        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   2        |
      Gingiva, Squamous Cell Carcinoma     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +     +        +        +                                                |  29        |
      Adenoma                              |                         X                                                |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +     +     +  +        +  +                                             |  27        |
      Pheochromocytoma Benign              |       X     X                                                            |          3 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 6| 5| 4| 6| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6|                                            |            |
                                           | 1| 1| 4| 5| 8| 3| 6| 7| 6| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Adenoma                              | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Adenoma               |    X        X        X  X                                                |         34 |
      Pars Distalis, Leukemia Mononuclear  |       X                 X                                                |          7 |
      Pars Intermedia, Adenoma             |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      C-Cell, Adenoma                      |          X                                                               |          6 |
      C-Cell, Adenoma, Multiple            |             X                                                            |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                                                                          |          1 |
      Bilateral, Carcinoma                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bilateral, Interstitial Cell, Adenoma| X  X        X  X           X                                             |         24 |
      Interstitial Cell, Adenoma           |       X  X        X                                                      |         21 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Femoral, Histiocytic Sarcoma         |                                                                          |          1 |
      Femoral, Leukemia Mononuclear        |       X  X                                                               |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |   8        |
      Mediastinal, Histiocytic Sarcoma     |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |          X                                                               |          6 |
      Renal, Histiocytic Sarcoma           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +  +              +                                                |  13        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X              X                                                |         11 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 6| 5| 4| 6| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6|                                            |            |
                                           | 1| 1| 4| 5| 8| 3| 6| 7| 6| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +              +                                                |   9        |
      Leukemia Mononuclear                 |          X              X                                                |          8 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma                  |                X                                                         |          2 |
      Leukemia Mononuclear                 |       X  X     X        X                                                |         23 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Leukemia Mononuclear                 |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +                                             |  55        |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |                                                                          |          1 |
      Fibroma                              | X           X                                                            |          3 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Sebaceous Gland, Lip, Carcinoma      |                X                                                         |          1 |
      Subcutaneous Tissue, Neurofibroma    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin, Control                           |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-Mass          |    +  +        +                                                         |   5        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |                                                                          |   2        |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-Mass          |    +  +        +                                                         |   5        |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Maxilla, Osteosarcoma                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   5        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 6| 5| 4| 6| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6|                                            |            |
                                           | 1| 1| 4| 5| 8| 3| 6| 7| 6| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X              X                                                |         10 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
      Squamous Cell Papilloma              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Carcinoma                            |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Transitional Epithelium, Carcinoma   |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                X                                                         |          3 |
      Leukemia Mononuclear                 |       X  X     X        X                                                |         23 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 7| 3| 5| 2| 7| 6| 4| 7| 7| 6| 4| 6| 4| 6| 6| 4| 6| 7| 5| 6| 5| 4|             
                             DAY ON TEST   | 6| 6| 7| 3| 7| 4| 6| 1| 9| 5| 3| 3| 9| 5| 3| 5| 1| 3| 5| 3| 3| 9| 7| 4| 5|             
                                           | 4| 1| 9| 0| 9| 1| 4| 0| 1| 7| 0| 0| 8| 6| 8| 6| 2| 2| 6| 9| 0| 1| 0| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    .15                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                            X                                             |             
                                            __________________________________________________________________________|             
   Skin, Control                           |          +                                                  +            |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |       +                                                                  |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 7| 3| 5| 2| 7| 6| 4| 7| 7| 6| 4| 6| 4| 6| 6| 4| 6| 7| 5| 6| 5| 4|             
                             DAY ON TEST   | 6| 6| 7| 3| 7| 4| 6| 1| 9| 5| 3| 3| 9| 5| 3| 5| 1| 3| 5| 3| 3| 9| 7| 4| 5|             
                                           | 4| 1| 9| 0| 9| 1| 4| 0| 1| 7| 0| 0| 8| 6| 8| 6| 2| 2| 6| 9| 0| 1| 0| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    .15                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 6| 6| 5| 4| 4| 5| 7| 5| 6| 7| 6| 4| 7| 6| 7| 6| 7| 6| 7| 6| 5| 6|             
                             DAY ON TEST   | 2| 5| 7| 7| 2| 9| 5| 9| 7| 2| 7| 0| 3| 6| 5| 3| 9| 3| 7| 3| 5| 3| 5| 5| 2|             
                                           | 3| 6| 9| 5| 6| 3| 6| 9| 8| 2| 6| 6| 0| 8| 6| 0| 8| 1| 1| 1| 9| 1| 9| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .15                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                          +               |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                                                                          |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 6| 6| 5| 4| 4| 5| 7| 5| 6| 7| 6| 4| 7| 6| 7| 6| 7| 6| 7| 6| 5| 6|             
                             DAY ON TEST   | 2| 5| 7| 7| 2| 9| 5| 9| 7| 2| 7| 0| 3| 6| 5| 3| 9| 3| 7| 3| 5| 3| 5| 5| 2|             
                                           | 3| 6| 9| 5| 6| 3| 6| 9| 8| 2| 6| 6| 0| 8| 6| 0| 8| 1| 1| 1| 9| 1| 9| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .15                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 6| 7| 5| 6| 4| 6|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 1| 1| 1| 5| 1| 5| 2|                                            |            |
                                           | 1| 1| 1| 2| 0| 2| 6| 6| 6| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    .15                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Subcutaneous Tissue, Fibrosarcoma    |       X                                                                  |          1 |
      Subcutaneous Tissue, Fibrous         |                                                                          |            |
          Histiocytoma                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin, Control                           |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |                                                                          |   1        |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 6| 7| 5| 6| 4| 6|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 1| 1| 1| 5| 1| 5| 2|                                            |            |
                                           | 1| 1| 1| 2| 0| 2| 6| 6| 6| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    .15                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 7| 6| 4| 6| 7| 5| 5| 6| 4| 4| 6| 7| 6| 6| 5| 3| 7| 4| 6| 6| 4|             
                             DAY ON TEST   | 5| 0| 6| 8| 0| 4| 1| 7| 2| 2| 9| 6| 3| 5| 4| 1| 3| 9| 1| 6| 2| 5| 5| 4| 8|             
                                           | 6| 0| 4| 2| 7| 3| 6| 6| 9| 3| 9| 6| 7| 6| 8| 8| 2| 6| 1| 7| 9| 6| 5| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                    X                     |             
      Basosquamous Tumor Benign            |                                                                          |             
      Keratoacanthoma                      |                      X                                                   |             
      Subcutaneous Tissue, Fibroma         | X                                                                        |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |             +  +                       +              +        +         |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                             +            |             
      Keratoacanthoma                      |                                                                          |             
      Sebaceous Gland, Carcinoma           |                                                             X            |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |             +  +                       +              +        +         |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                             +            |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 7| 6| 4| 6| 7| 5| 5| 6| 4| 4| 6| 7| 6| 6| 5| 3| 7| 4| 6| 6| 4|             
                             DAY ON TEST   | 5| 0| 6| 8| 0| 4| 1| 7| 2| 2| 9| 6| 3| 5| 4| 1| 3| 9| 1| 6| 2| 5| 5| 4| 8|             
                                           | 6| 0| 4| 2| 7| 3| 6| 6| 9| 3| 9| 6| 7| 6| 8| 8| 2| 6| 1| 7| 9| 6| 5| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 5| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6| 0| 5| 7| 5| 6| 1| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 5| 5| 8| 2| 2| 3| 3| 6| 7| 0| 2| 2| 1| 2| 3| 2| 2| 8| 9| 2| 0| 9| 2| 1|             
                                           | 7| 6| 6| 9| 9| 9| 5| 5| 2| 1| 5| 6| 7| 3| 5| 7| 9| 6| 3| 9| 1| 1| 8| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5                                    | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Basosquamous Tumor Benign            |                      X                                                   |             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                       +                  |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +                                                                     |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Sebaceous Gland, Carcinoma           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +                                                                     |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                                          |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 5| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6| 0| 5| 7| 5| 6| 1| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 5| 5| 8| 2| 2| 3| 3| 6| 7| 0| 2| 2| 1| 2| 3| 2| 2| 8| 9| 2| 0| 9| 2| 1|             
                                           | 7| 6| 6| 9| 9| 9| 5| 5| 2| 1| 5| 6| 7| 3| 5| 7| 9| 6| 3| 9| 1| 1| 8| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5                                    | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 4| 6| 7| 5| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 5| 6| 3| 7| 3| 3| 5| 1|                                            |            |
                                           | 8| 2| 6| 3| 0| 5| 0| 0| 8| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.5                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Basosquamous Tumor Benign            |                                                                          |          1 |
      Keratoacanthoma                      |             X        X                                                   |          3 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin, Control                           |             +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |       +        +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-Mass          |          +                                                               |   3        |
      Keratoacanthoma                      |          X                                                               |          1 |
      Sebaceous Gland, Carcinoma           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |       +        +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-Mass          |          +                                                               |   3        |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  49                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 4| 6| 7| 5| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 5| 6| 3| 7| 3| 3| 5| 1|                                            |            |
                                           | 8| 2| 6| 3| 0| 5| 0| 0| 8| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.5                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |             X                                                            |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  50                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|             
                             DAY ON TEST   | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|             
                                           | 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +                                                                     |             
      Adenoma                              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                         +              +           +                     |             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                        +                                 |             
      Adenocarcinoma                       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X  X              X     X  X     X     X  X  X     X        X|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                               +                     |             
      Leukemia Mononuclear                 |                                                    X                     |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +        +  +              +  +                             +        +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +           +     +           +                    +           +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                            X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +           +  +  +  +  +  +           +     +                     |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Lung                            |                   X                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +        +           +     +  +  +     +     +     +  +        +     +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
      Bilateral, Pheochromocytoma Benign   |                                                    X           X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |       X                 X  X     X     X  X              X              X|             
      Pars Distalis, Leukemia Mononuclear  |          X  X                 X                       X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      C-Cell, Adenoma                      |       X                 X                    X     X                    X|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|             
                             DAY ON TEST   | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|             
                                           | 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Mesothelioma Benign          |                                                             X            |             
      Serosa, Mesothelioma Malignant       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                X                                                         |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                         X                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X           X              X        X                 X     X  X|             
      Interstitial Cell, Adenoma           |                X  X     X     X        X           X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |          X  X  X              X                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +  +  +           +              +     +  +  +     +         |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |          X                                            X                  |             
      Inguinal, Leukemia Mononuclear       |                                                       X                  |             
      Lumbar, Leukemia Mononuclear         |          X                                                               |             
      Mediastinal, Leukemia Mononuclear    |          X  X  X              X              X     X  X  X               |             
      Pancreatic, Leukemia Mononuclear     |                                                       X                  |             
      Renal, Leukemia Mononuclear          |          X                                                               |             
      Thoracic, Squamous Cell Carcinoma,   |                                                                          |             
           Metastatic, Lung                |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +  +  +     +        +              +     +  +                 +|             
      Leukemia Mononuclear                 |          X  X  X              X              X     X  X                 X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +  +  +           +  +              +     +  +        +        +|             
      Leukemia Mononuclear                 |          X  X  X              X              X     X  X                 X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                     X                                    |             
      Leukemia Mononuclear                 |    X     X  X  X              X     X  X     X     X  X  X              X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X              X              X     X  X  X               |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Lung                            |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|             
                             DAY ON TEST   | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|             
                                           | 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibroadenoma                         |    X                                   X                                 |             
      Fibroma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |       X                                                                  |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                   +                 +     +     +                 +      |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                              +                           |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                   +                 +     +     +                 +      |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                              +                           |             
      Keratoacanthoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                   +                 +     +     +                 +      |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                              +                           |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                   +                 +     +     +                 +      |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma NOS                      |                                                                          |             
      Leukemia Mononuclear                 |                                                          X              X|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                    +                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X  X              X              X     X  X  X              X|             
      Squamous Cell Carcinoma              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                       +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                       X                 X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                         X                     |             
      Transitional Epithelium, Papilloma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|             
                             DAY ON TEST   | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|             
                                           | 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                     X                                    |             
      Leukemia Mononuclear                 |    X     X  X  X              X     X  X     X     X  X  X     X        X|             
      Mesothelioma Benign                  |                                                             X            |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|             
                                           | 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                          |             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X  X  X     X     X  X     X  X                       X   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                  +        +     +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               | X                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +        +                    +        +     +                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +                    +     +     +                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                 +                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |       +     +  +     +           +  +  +     +  +  +  +     +     +      |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Lung                            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |       +        +     +           +        +  +  +        +           +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Pheochromocytoma Malignant           |                                                          X               |             
      Pheochromocytoma Benign              |                X                 X           X                           |             
      Bilateral, Pheochromocytoma Benign   |                                                                         X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Pars Distalis, Adenoma               | X     X  X  X  X  X  X                 X     X  X  X  X     X  X  X      |             
      Pars Distalis, Leukemia Mononuclear  |                                           X                          X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                      X                                         X  X      |             
      Follicular Cell, Adenoma             |                                        X           X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|             
                                           | 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Mesothelioma Benign          |                                                                          |             
      Serosa, Mesothelioma Malignant       | X                                                                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X     X     X              X     X  X     X  X  X  X  X  X        X     X|             
      Interstitial Cell, Adenoma           |                   X     X     X                                      X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                      X     X                                         X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +                 +              +                          +   |             
      Axillary, Leukemia Mononuclear       |                                                                      X   |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                            X              X                          X   |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                           X                              |             
      Thoracic, Squamous Cell Carcinoma,   |                                                                          |             
           Metastatic, Lung                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                      +     +     +        +  +                       +   |             
      Leukemia Mononuclear                 |                      X     X     X        X  X                       X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                      +                    +                          +   |             
      Leukemia Mononuclear                 |                      X                    X                          X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X        X  X  X     X     X  X     X  X                       X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Lung                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|             
                                           | 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibroadenoma                         |       X                                                                  |             
      Fibroma                              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                   X      |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                  X                                       |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +              +              +     +                    +  +         |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                                      +  +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +              +              +     +                    +  +         |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                                      +  +|             
      Keratoacanthoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +              +              +     +                    +  +         |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                                      +  +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +              +              +     +                    +  +         |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma NOS                      |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                     +                                    |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X     X        X                              |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Transitional Epithelium, Papilloma   |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|             
                                           | 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                      X           X                                       |             
      Leukemia Mononuclear                 |       X        X  X  X     X     X  X     X  X                       X   |             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 4| 3| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2|                                            |            |
                                           | 9| 9| 5| 4| 9| 6| 6| 0| 9| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    1.5                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |   3        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   1        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X  X  X     X     X  X  X                                                |         30 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +        +                                                            |   8        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  11        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |             +                                                            |  24        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Lung                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +           +                                                |  29        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |          X                                                               |          4 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |                         X                                                |          3 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               |          X                 X                                             |         25 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 4| 3| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2|                                            |            |
                                           | 9| 9| 5| 4| 9| 6| 6| 0| 9| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    1.5                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Leukemia Mononuclear  |                         X                                                |          7 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                X                                                         |          9 |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Serosa, Mesothelioma Benign          |                                                                          |          1 |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X     X        X  X                                                |         30 |
      Interstitial Cell, Adenoma           |                                                                          |         10 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femoral, Leukemia Mononuclear        | X           X                                                            |         10 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  14        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          2 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Lumbar, Leukemia Mononuclear         |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |         11 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          2 |
      Thoracic, Squamous Cell Carcinoma,   |                                                                          |            |
           Metastatic, Lung                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                   +     +                                                |  17        |
      Leukemia Mononuclear                 |                   X     X                                                |         16 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 4| 3| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2|                                            |            |
                                           | 9| 9| 5| 4| 9| 6| 6| 0| 9| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    1.5                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                                      |  14        |
      Leukemia Mononuclear                 |                   X                                                      |         12 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 | X  X  X     X     X  X  X                                                |         29 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  M  +  M  +  M  +                                             |  51        |
      Leukemia Mononuclear                 |                                                                          |          7 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Lung                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Fibroadenoma                         |                                                                          |          3 |
      Fibroma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |          +     +  +        +                                             |  16        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-Mass          |                      +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |          +     +  +        +                                             |  16        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-Mass          |                      +                                                   |   4        |
      Keratoacanthoma                      |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |          +     +  +        +                                             |  16        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-Mass          |                      +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |          +     +  +        +                                             |  16        |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Astrocytoma NOS                      |          X                                                               |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05102-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/01/97  
Route: DERMAL,SOLUTION                                                                                            Time: 16:16:55  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 4| 3| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2|                                            |            |
                                           | 9| 9| 5| 4| 9| 6| 6| 0| 9| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    1.5                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |    X        X     X                                                      |         15 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  M                                             |  59        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Transitional Epithelium, Papilloma   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                                                                          |          3 |
      Leukemia Mononuclear                 | X  X  X     X     X  X  X                                                |         30 |
      Mesothelioma Benign                  |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
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