TDMS Study 05102-05 Pathology Tables
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
Facility: Battelle Columbus Laboratory
Chemical CAS #: 121-54-0
Lock Date: 01/24/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 4| 6| 4| 5| 7| 7| 4| 7| 7| 1| 7| 6| 4| 6| 6| 6| 7| 7|
DAY ON TEST | 3| 2| 4| 3| 3| 3| 7| 5| 9| 5| 1| 3| 2| 5| 3| 3| 7| 3| 4| 5| 1| 4| 4| 3| 3|
| 1| 4| 8| 1| 1| 1| 2| 6| 6| 6| 9| 1| 4| 6| 1| 1| 6| 1| 9| 6| 0| 4| 2| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X X X |
Hepatodiaphragmatic Nodule | X X X X X X |
Hepatodiaphragmatic Nodule, Multiple | X |
Inflammation, Chronic Active | |
Inflammation, Granulomatous | 1 |
Bile Duct, Hyperplasia | 3 2 1 2 |
Hepatocyte, Necrosis | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 1 2 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + |
Ulcer | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 2 2 1 2 1 1 1 2 2 1 1 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + |
Degeneration, Cystic | |
Hyperplasia | 2 2 2 2 2 |
Necrosis | |
Vacuolization Cytoplasmic | 3 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | 2 2 3 3 3 3 2 2 2 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 4| 6| 4| 5| 7| 7| 4| 7| 7| 1| 7| 6| 4| 6| 6| 6| 7| 7|
DAY ON TEST | 3| 2| 4| 3| 3| 3| 7| 5| 9| 5| 1| 3| 2| 5| 3| 3| 7| 3| 4| 5| 1| 4| 4| 3| 3|
| 1| 4| 8| 1| 1| 1| 2| 6| 6| 6| 9| 1| 4| 6| 1| 1| 6| 1| 9| 6| 0| 4| 2| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | X X X X X X|
Pars Distalis, Hyperplasia | 3 2 2 2 2 3 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Inflammation, Chronic Active | 2 3 |
Duct, Cyst | X |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X X |
Periovarian Tissue, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 |
__________________________________________________________________________|
Vagina | |
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Erythrocyte, Atypia Cellular | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
Thrombosis | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 3 2 3 3 2 3 3 3 2 2 2 3 2 2 3 2 2 2 2 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | |
Acanthosis | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 4| 6| 4| 5| 7| 7| 4| 7| 7| 1| 7| 6| 4| 6| 6| 6| 7| 7|
DAY ON TEST | 3| 2| 4| 3| 3| 3| 7| 5| 9| 5| 1| 3| 2| 5| 3| 3| 7| 3| 4| 5| 1| 4| 4| 3| 3|
| 1| 4| 8| 1| 1| 1| 2| 6| 6| 6| 9| 1| 4| 6| 1| 1| 6| 1| 9| 6| 0| 4| 2| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Sebaceous Gland, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 2 2 3 2 2 3 3 |
Hemorrhage | |
Hydrocephalus | 2 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Perivascular, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Chronic Active | 3 1 |
Sinus, Foreign Body | 2 |
Submucosa, Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + +|
Phthisis Bulbi | |
Lens, Cataract | 4 3 4|
Retina, Atrophy | 4 4 4|
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Mineralization | 2 2 2 |
Nephropathy, Chronic | 2 4 3 3 2 2 2 3 2 2 3 3 3 3 2 1 1 3 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 6| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 5| 3| 3| 3| 3| 5| 2| 3| 8| 9| 3| 3| 4| 3| 2| 3| 6| 1| 3| 3| 3| 5| 3| 3|
| 6| 6| 1| 1| 3| 1| 4| 0| 1| 5| 5| 1| 1| 5| 1| 6| 1| 7| 9| 1| 1| 1| 6| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3|
Basophilic Focus | X X X X X X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X|
Hepatodiaphragmatic Nodule | X |
Hepatodiaphragmatic Nodule, Multiple | |
Inflammation, Chronic Active | 2 |
Inflammation, Granulomatous | 2 2 2 2 2 2|
Bile Duct, Hyperplasia | 2 1 2 1 2 |
Hepatocyte, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 2 4 4 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + |
Ulcer | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 1 2 1 1 1 1 2 1 1 1|
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + |
Degeneration, Cystic | 2 |
Hyperplasia | 2 |
Necrosis | |
Vacuolization Cytoplasmic | 2 4 2 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + +|
Hyperplasia | 2 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 3 2 3 1 2 2 3 2 3 1 2 2 2 3 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 6| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 5| 3| 3| 3| 3| 5| 2| 3| 8| 9| 3| 3| 4| 3| 2| 3| 6| 1| 3| 3| 3| 5| 3| 3|
| 6| 6| 1| 1| 3| 1| 4| 0| 1| 5| 5| 1| 1| 5| 1| 6| 1| 7| 9| 1| 1| 1| 6| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 3 2 2 3 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 3 2 2 3 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 |
Inflammation, Chronic Active | |
Duct, Cyst | |
Duct, Ectasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X X |
Periovarian Tissue, Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 4 |
__________________________________________________________________________|
Vagina | + |
Lumen, Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Erythrocyte, Atypia Cellular | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + |
Thrombosis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + M + + M + +|
Depletion Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 2 2 3 3 3 3 3 3 2 2 3 2 2 2 4 3 2 3 3 3 3 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + |
Acanthosis | 3 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 6| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 5| 3| 3| 3| 3| 5| 2| 3| 8| 9| 3| 3| 4| 3| 2| 3| 6| 1| 3| 3| 3| 5| 3| 3|
| 6| 6| 1| 1| 3| 1| 4| 0| 1| 5| 5| 1| 1| 5| 1| 6| 1| 7| 9| 1| 1| 1| 6| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Sebaceous Gland, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 3 3 2 2 2 |
Hemorrhage | |
Hydrocephalus | 3 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Chronic Active | 3 3 |
Sinus, Foreign Body | 3 2 |
Submucosa, Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Phthisis Bulbi | X |
Lens, Cataract | 4 4 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Mineralization | 3 2 3 |
Nephropathy, Chronic | 1 4 3 2 3 2 3 1 1 2 3 2 1 2 2 2 3 3 2 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 6| 5| 4| 7| 6| | |
DAY ON TEST | 1| 5| 3| 0| 2| 4| 1| 5| 0| 1| | |
| 8| 6| 1| 3| 2| 2| 5| 6| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 2 |
Ulcer | 2 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.0|
Basophilic Focus | X X X X | 26 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | X X X | 13 |
Hepatodiaphragmatic Nodule | X X | 9 |
Hepatodiaphragmatic Nodule, Multiple | | 1 |
Inflammation, Chronic Active | 2 | 2 2.0|
Inflammation, Granulomatous | 2 | 8 1.9|
Bile Duct, Hyperplasia | 1 2 | 11 1.7|
Hepatocyte, Necrosis | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 4 3 | 7 3.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Inflammation, Chronic Active | | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 2 1 1 | 15 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 6 |
Ulcer | 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 1 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Degeneration, Chronic | 2 1 1 2 1 2 | 29 1.3|
Atrium, Thrombosis | X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 19 |
Degeneration, Cystic | | 1 2.0|
Hyperplasia | 2 | 7 2.0|
Necrosis | 3 3 | 2 3.0|
Vacuolization Cytoplasmic | 2 | 8 2.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 10 |
Hyperplasia | | 6 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 6| 5| 4| 7| 6| | |
DAY ON TEST | 1| 5| 3| 0| 2| 4| 1| 5| 0| 1| | |
| 8| 6| 1| 3| 2| 2| 5| 6| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M M | 56 |
Hyperplasia | 3 3 3 | 32 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Necrosis | | 1 2.0|
Pars Distalis, Cyst | X | 11 |
Pars Distalis, Hyperplasia | 2 2 | 17 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | 2 2 2 | 24 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + | 59 |
Hyperplasia | 2 | 5 2.6|
Inflammation, Chronic Active | | 2 2.5|
Duct, Cyst | | 1 |
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Follicle, Cyst | | 4 |
Periovarian Tissue, Cyst | X X | 8 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | | 3 2.7|
__________________________________________________________________________|____________|
Vagina | | 1 |
Lumen, Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 2 |
Erythrocyte, Atypia Cellular | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Femoral, Myelofibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 7 |
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 6| 5| 4| 7| 6| | |
DAY ON TEST | 1| 5| 3| 0| 2| 4| 1| 5| 0| 1| | |
| 8| 6| 1| 3| 2| 2| 5| 6| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + M + | 54 |
Depletion Lymphoid | 2 2 | 8 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia, Cystic | 3 3 3 3 3 3 3 2 3 2 | 58 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + | 2 |
Acanthosis | 1 | 2 2.0|
Sebaceous Gland, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Femur, Hyperostosis | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | 2 3 3 3 2 | 21 2.4|
Hemorrhage | 2 | 1 2.0|
Hydrocephalus | 2 3 | 8 2.3|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 2 | 2 2.0|
Perivascular, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Mucosa, Inflammation, Chronic Active | | 4 2.5|
Sinus, Foreign Body | | 3 2.3|
Submucosa, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 6 |
Phthisis Bulbi | | 1 |
Lens, Cataract | | 5 3.8|
Retina, Atrophy | | 5 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 6| 5| 4| 7| 6| | |
DAY ON TEST | 1| 5| 3| 0| 2| 4| 1| 5| 0| 1| | |
| 8| 6| 1| 3| 2| 2| 5| 6| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 |
Mineralization | 2 3 | 8 2.4|
Nephropathy, Chronic | 2 1 3 1 3 3 1 2 1 | 48 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 7| 5| 6| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 4| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 5| 0| 5| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3|
| 0| 1| 2| 6| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 9| 6| 0| 0| 6| 8| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.15 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
__________________________________________________________________________|
Skin, Control | |
Acanthosis | |
Sebaceous Gland, Hyperplasia | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + |
Acanthosis | 3 4 |
Ulcer | 3 |
Sebaceous Gland, Hyperplasia | 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 7| 7| 3| 7| 7| 4| 7| 3| 6| 6| 7| 6| 5| 7| 4| 6| 7| 7| 4| 6| 4|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 9| 3| 3| 5| 3| 6| 1| 3| 3| 8| 8| 3| 5| 1| 3| 3| 5| 7| 5|
| 8| 0| 6| 0| 0| 0| 3| 0| 0| 6| 0| 6| 2| 3| 0| 0| 2| 0| 6| 2| 0| 1| 6| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.15 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
__________________________________________________________________________|
Skin, Control | + |
Acanthosis | 2 |
Sebaceous Gland, Hyperplasia | 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + |
Acanthosis | 3 |
Ulcer | 2 |
Sebaceous Gland, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 2| 3| 8| 3| 3| 3| 3| 1| | |
| 1| 1| 7| 1| 4| 1| 1| 1| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.15 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Skin, Control | | 1 |
Acanthosis | | 1 2.0|
Sebaceous Gland, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | | 3 |
Acanthosis | | 3 3.3|
Ulcer | | 2 2.5|
Sebaceous Gland, Hyperplasia | | 3 2.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 2| 3| 8| 3| 3| 3| 3| 1| | |
| 1| 1| 7| 1| 4| 1| 1| 1| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.15 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 5| 7| 4| 6| 4| 5| 4| 6| 4| 7| 6| 2| 7| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 7| 4| 2| 2| 7| 2| 5| 8| 5| 3| 5| 7| 5| 2| 3| 9| 0| 1| 2| 2| 2| 3| 0| 1| 3|
| 9| 9| 9| 9| 9| 9| 6| 6| 6| 3| 6| 8| 6| 9| 2| 7| 8| 0| 9| 9| 9| 0| 6| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | 4 |
__________________________________________________________________________|
Skin, Control | |
Acanthosis | |
Sebaceous Gland, Hyperplasia | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + |
Acanthosis | 3 1 2 3 |
Ulcer | 3 3 |
Sebaceous Gland, Hyperplasia | 2 1 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 5| 7| 4| 6| 4| 5| 4| 6| 4| 7| 6| 2| 7| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 7| 4| 2| 2| 7| 2| 5| 8| 5| 3| 5| 7| 5| 2| 3| 9| 0| 1| 2| 2| 2| 3| 0| 1| 3|
| 9| 9| 9| 9| 9| 9| 6| 6| 6| 3| 6| 8| 6| 9| 2| 7| 8| 0| 9| 9| 9| 0| 6| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 7| 4| 4| 4| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 4| 4| 6| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 5| 5| 5| 8| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 9| 6| 8| 3| 3| 3| 7| 2| 0|
| 0| 6| 6| 6| 1| 0| 0| 0| 0| 0| 8| 0| 0| 4| 8| 0| 2| 5| 5| 0| 0| 0| 9| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
__________________________________________________________________________|
Skin, Control | + |
Acanthosis | 2 |
Sebaceous Gland, Hyperplasia | 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + |
Acanthosis | 3 3 4 |
Ulcer | 2 4 |
Sebaceous Gland, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 7| 4| 4| 4| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 4| 4| 6| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 5| 5| 5| 8| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 9| 6| 8| 3| 3| 3| 7| 2| 0|
| 0| 6| 6| 6| 1| 0| 0| 0| 0| 0| 8| 0| 0| 4| 8| 0| 2| 5| 5| 0| 0| 0| 9| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 5| 7| 4| 7| 7| 6| 7| 4| 7| 7| | |
DAY ON TEST | 6| 3| 5| 3| 3| 6| 2| 5| 3| 3| | |
| 5| 0| 6| 0| 0| 8| 5| 6| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 1 3.0|
Hyperkeratosis | | 1 4.0|
__________________________________________________________________________|____________|
Skin, Control | | 1 |
Acanthosis | | 1 2.0|
Sebaceous Gland, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + | 8 |
Acanthosis | 3 | 8 2.8|
Ulcer | | 4 3.0|
Sebaceous Gland, Hyperplasia | 1 | 7 1.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 5| 7| 4| 7| 7| 6| 7| 4| 7| 7| | |
DAY ON TEST | 6| 3| 5| 3| 3| 6| 2| 5| 3| 3| | |
| 5| 0| 6| 0| 0| 8| 5| 6| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7| 4| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5|
DAY ON TEST | 2| 6| 2| 2| 2| 2| 5| 8| 2| 5| 2| 5| 2| 5| 3| 2| 2| 2| 4| 8| 4| 2| 9| 2| 2|
| 9| 8| 9| 9| 9| 9| 6| 7| 9| 6| 9| 6| 9| 6| 4| 9| 9| 9| 7| 0| 0| 9| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X X X |
Hepatodiaphragmatic Nodule | X X X X X X X X |
Inflammation, Chronic Active | 2 2 |
Inflammation, Granulomatous | 2 2 2 2 |
Bile Duct, Hyperplasia | 2 3 2 3 2 2 |
Hepatocyte, Degeneration, Cystic | |
Hepatocyte, Hypertrophy, Focal | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | 2 2 2 2 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + |
Acanthosis | 3 |
Inflammation, Chronic Active | |
Mineralization | |
Ulcer | 3 2 |
__________________________________________________________________________|
Tongue | +|
Cyst | X|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
Atrium, Thrombosis | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + |
Degeneration, Cystic | 3 |
Hyperplasia | 2 2 2 2 2 2 |
Hypertrophy | 2 |
Necrosis | 3 |
Vacuolization Cytoplasmic | 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + M + + + + + + + + + + M + + M M|
Hyperplasia | 3 3 3 4 2 3 3 3 3 3 2 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7| 4| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5|
DAY ON TEST | 2| 6| 2| 2| 2| 2| 5| 8| 2| 5| 2| 5| 2| 5| 3| 2| 2| 2| 4| 8| 4| 2| 9| 2| 2|
| 9| 8| 9| 9| 9| 9| 6| 7| 9| 6| 9| 6| 9| 6| 4| 9| 9| 9| 7| 0| 0| 9| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Craniopharyngeal Duct, Pars Distalis,| |
Cyst | |
Pars Distalis, Cyst | X X X X X X |
Pars Distalis, Hyperplasia | 4 3 2 3 2 3 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 3 2 2 2 2 2 2 2 2 3 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 2 |
Inflammation, Chronic Active | |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X X |
Periovarian Tissue, Cyst | X X X X X X X X X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | +|
Angiectasis | 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + M + + + + + + + + + + M + +|
Angiectasis | |
Cyst | |
Depletion Lymphoid | 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 2 2 3 2 2 3 3 3 3 3 2 4 3 3 3 4 2 2 3 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + |
Acanthosis | 3 2 4 3 3 3 3 3 2 3 2 3 3 3 3 3 3 1 3 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7| 4| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5|
DAY ON TEST | 2| 6| 2| 2| 2| 2| 5| 8| 2| 5| 2| 5| 2| 5| 3| 2| 2| 2| 4| 8| 4| 2| 9| 2| 2|
| 9| 8| 9| 9| 9| 9| 6| 7| 9| 6| 9| 6| 9| 6| 4| 9| 9| 9| 7| 0| 0| 9| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Erosion, Focal | 2 |
Ulcer | 2 3 1 2 1 2 3 2 2 2 2 |
Sebaceous Gland, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | X X |
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 2 3 2 2 2 2 |
Hydrocephalus | 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Chronic Active | 3 2 |
Sinus, Foreign Body | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 3 4 3 |
Retina, Atrophy | 4 4 4 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 2 2 1 |
Nephropathy, Chronic | 2 2 3 2 3 1 1 1 1 2 2 2 1 2 3 3 2 2 2 4 3 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 5| 6| 7| 4| 6| 6| 3| 7| 7| 7| 6| 4| 4| 7| 3| 5| 5| 6| 5| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 8| 1| 2| 5| 6| 3| 0| 2| 2| 2| 5| 8| 5| 2| 2| 9| 3| 3| 3| 2| 2| 2| 7| 3| 2|
| 7| 9| 9| 6| 7| 2| 3| 9| 9| 9| 8| 6| 6| 9| 2| 4| 3| 4| 7| 3| 9| 9| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.5 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Eosinophilic Focus | X X X X X X |
Hepatodiaphragmatic Nodule | X X X X X X |
Inflammation, Chronic Active | |
Inflammation, Granulomatous | 2 2 2 2 2 |
Bile Duct, Hyperplasia | 2 2 2 1 3 2|
Hepatocyte, Degeneration, Cystic | 2 2 |
Hepatocyte, Hypertrophy, Focal | |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 3 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic Active | 3 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Acinus, Atrophy | 2 2 2 2 2 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + |
Acanthosis | 3 3 |
Inflammation, Chronic Active | 3 |
Mineralization | 2 |
Ulcer | 2 3 3 |
__________________________________________________________________________|
Tongue | |
Cyst | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 1 1 2 1 1 1 2 1 1 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia | 2 2 2 2 2|
Hypertrophy | |
Necrosis | 3 |
Vacuolization Cytoplasmic | 2 2 3 2 2|
__________________________________________________________________________|
Adrenal Medulla | + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + M + + + + + + + + + +|
Hyperplasia | 2 2 2 2 3 4 2 2 3 2 2 3 3 2 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 5| 6| 7| 4| 6| 6| 3| 7| 7| 7| 6| 4| 4| 7| 3| 5| 5| 6| 5| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 8| 1| 2| 5| 6| 3| 0| 2| 2| 2| 5| 8| 5| 2| 2| 9| 3| 3| 3| 2| 2| 2| 7| 3| 2|
| 7| 9| 9| 6| 7| 2| 3| 9| 9| 9| 8| 6| 6| 9| 2| 4| 3| 4| 7| 3| 9| 9| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.5 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Craniopharyngeal Duct, Pars Distalis,| |
Cyst | |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 3 2 4 3 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 2 2|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X X X X|
Periovarian Tissue, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X |
Depletion Lymphoid | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 3 2 3 3 2 2 3 3 3 2 3 3 3 2 2 1 3 2 3 3 2 2 3 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + +|
Acanthosis | 2 3 2 2 3 1 3 3 3 2 2 2 3|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 5| 6| 7| 4| 6| 6| 3| 7| 7| 7| 6| 4| 4| 7| 3| 5| 5| 6| 5| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 8| 1| 2| 5| 6| 3| 0| 2| 2| 2| 5| 8| 5| 2| 2| 9| 3| 3| 3| 2| 2| 2| 7| 3| 2|
| 7| 9| 9| 6| 7| 2| 3| 9| 9| 9| 8| 6| 6| 9| 2| 4| 3| 4| 7| 3| 9| 9| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.5 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Erosion, Focal | |
Ulcer | 2 2 2 2 1 2 1 2|
Sebaceous Gland, Hyperplasia | 2 2 2 1 2 2 1 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | |
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 3 2 3 2 2 |
Hydrocephalus | 2 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Chronic Active | 2 2 |
Sinus, Foreign Body | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 1 |
Nephropathy, Chronic | 2 2 1 1 2 4 3 4 2 2 2 1 1 2 2 4 2 1 1 2 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 6| 4| 5| 3| | |
DAY ON TEST | 2| 0| 7| 0| 2| 2| 1| 5| 6| 5| | |
| 9| 3| 7| 0| 9| 9| 3| 6| 2| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.5 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X X X | 33 |
Clear Cell Focus | X | 7 |
Eosinophilic Focus | X X X | 13 |
Hepatodiaphragmatic Nodule | X X X X | 18 |
Inflammation, Chronic Active | | 2 2.0|
Inflammation, Granulomatous | 2 1 | 11 1.9|
Bile Duct, Hyperplasia | 1 | 13 2.1|
Hepatocyte, Degeneration, Cystic | | 2 2.0|
Hepatocyte, Hypertrophy, Focal | | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| | 8 2.1|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Inflammation, Chronic Active | | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 4.0|
Acinus, Atrophy | 1 1 1 | 17 1.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 8 |
Acanthosis | | 3 3.0|
Inflammation, Chronic Active | | 1 3.0|
Mineralization | | 1 2.0|
Ulcer | | 5 2.6|
__________________________________________________________________________|____________|
Tongue | | 1 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Degeneration, Chronic | 2 1 1 1 1 | 33 1.2|
Atrium, Thrombosis | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 21 |
Degeneration, Cystic | | 1 3.0|
Hyperplasia | 2 | 12 2.0|
Hypertrophy | | 1 2.0|
Necrosis | | 2 3.0|
Vacuolization Cytoplasmic | 2 | 9 2.1|
__________________________________________________________________________|____________|
Adrenal Medulla | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 6| 4| 5| 3| | |
DAY ON TEST | 2| 0| 7| 0| 2| 2| 1| 5| 6| 5| | |
| 9| 3| 7| 0| 9| 9| 3| 6| 2| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.5 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 53 |
Hyperplasia | 2 2 2 | 32 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Craniopharyngeal Duct, Pars Distalis,| | |
Cyst | X | 1 |
Pars Distalis, Cyst | X X | 12 |
Pars Distalis, Hyperplasia | 3 2 2 3 | 20 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Bilateral, Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 2 2 2 2 | 17 2.1|
Follicular Cell, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + + + | 59 |
Hyperplasia | | 4 2.5|
Inflammation, Chronic Active | 4 | 1 4.0|
Duct, Ectasia | | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Follicle, Cyst | X | 7 |
Periovarian Tissue, Cyst | X | 13 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | | 3 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + M + | 59 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 3 |
Angiectasis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 2 3.0|
Hematopoietic Cell Proliferation | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 6| 4| 5| 3| | |
DAY ON TEST | 2| 0| 7| 0| 2| 2| 1| 5| 6| 5| | |
| 9| 3| 7| 0| 9| 9| 3| 6| 2| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.5 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | 2 | 1 2.0|
Cyst | | 1 |
Depletion Lymphoid | X 3 | 9 2.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia, Cystic | 3 2 2 3 3 3 2 3 2 | 56 2.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + | 39 |
Acanthosis | 3 3 3 2 3 3 | 38 2.7|
Erosion, Focal | | 1 2.0|
Ulcer | 2 2 2 1 | 23 1.9|
Sebaceous Gland, Hyperplasia | 2 2 1 1 2 2 | 36 1.9|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Femur, Hyperostosis | | 2 |
Femur, Osteopetrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | 2 3 | 17 2.2|
Hydrocephalus | | 6 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 4 |
__________________________________________________________________________|____________|
Spinal Cord | | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 1 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Mucosa, Inflammation, Chronic Active | 3 | 5 2.4|
Sinus, Foreign Body | 3 | 5 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Lens, Cataract | | 4 3.3|
Retina, Atrophy | | 4 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 6| 4| 5| 3| | |
DAY ON TEST | 2| 0| 7| 0| 2| 2| 1| 5| 6| 5| | |
| 9| 3| 7| 0| 9| 9| 3| 6| 2| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.5 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Mineralization | 2 | 9 1.9|
Nephropathy, Chronic | 2 3 1 3 4 1 2 1 1 | 53 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|
DAY ON TEST | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|
| 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
Inflammation, Chronic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic Active | 1 |
Inflammation, Granulomatous | 2 |
Bile Duct, Hyperplasia | 2 1 4 2 2 2 3 2 2 2 2 3 2 3 2|
Hepatocyte, Degeneration, Cystic | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 4 3 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Artery, Inflammation, Chronic Active | |
Fat, Hemorrhage | 2 |
Fat, Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 3 1 1 2 2 2 2 2|
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
Acanthosis | 3 3 3 |
Inflammation, Chronic Active | 3 |
Mineralization | |
Ulcer | 3 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + +|
Dysplasia | |
Mineralization | 3|
Necrosis | |
Pigmentation, Hemosiderin | 1 |
Ulcer | 2 3 |
__________________________________________________________________________|
Tongue | + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|
DAY ON TEST | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|
| 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 3 1 2 2 2 2 2 3 2 2 1 1 2 3 2 1 1 3 1 2|
Mineralization | |
Atrium, Thrombosis | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2|
Hypertrophy | 1 |
Vacuolization Cytoplasmic | 1 1 1 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + +|
Hyperplasia | 1 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 3 3 3 3 2 2 3 3 4 2 2 2 4 4|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 3 3 3 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 1 2 3 2 2|
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 3 3 2 1 2 2 2 2 2 3 1 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 2 3 2 3 3 3 2 3|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 2|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|
DAY ON TEST | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|
| 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + |
Pancreatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Angiectasis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 3 3 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + M M + + M + + + + + + + M|
Depletion Lymphoid | 3 3 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + M + + + M + + + + + + + + + +|
Hyperplasia, Cystic | 3 2 1 2 2 1 2 1 2 3 3 3 2 3 3 1 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | 4 |
__________________________________________________________________________|
Skin, Control | + |
Acanthosis | 3 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + |
Acanthosis | |
__________________________________________________________________________|
Skin, Site of Application-Mass | + |
Cyst Epithelial Inclusion | X |
Dermis, Fibrosis | |
Dermis, Mineralization | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + |
__________________________________________________________________________|
Skin, Site of Application-Mass | + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 2 2 2 2 3 |
Hemorrhage | |
Hydrocephalus | 2 2 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
Inflammation, Suppurative | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|
DAY ON TEST | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|
| 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Chronic Active | 3 3 |
Sinus, Foreign Body | 3 2 |
Submucosa, Inflammation, Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 3 2 3 4 3 3 4 3 4 4 4 4 4 2 4 4 3 4 4 3 4 4 2 4|
Cortex, Cyst | |
Cortex, Renal Tubule, Mineralization | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|
DAY ON TEST | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|
| 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X|
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X|
Inflammation, Chronic Active | 1 2 |
Inflammation, Granulomatous | 2 |
Bile Duct, Hyperplasia | 2 1 2 3 2 2 4 1 1 2 2 2 3|
Hepatocyte, Degeneration, Cystic | 2 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 1 2 1 3 3 2 2 4 2 |
__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation, Chronic Active | |
Fat, Hemorrhage | |
Fat, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 3 3 1 2 2 2 2|
Artery, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + |
Acanthosis | 3 |
Inflammation, Chronic Active | |
Mineralization | 2 |
Ulcer | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + |
Dysplasia | 2 2 |
Mineralization | 3 2 1 3 |
Necrosis | 2 |
Pigmentation, Hemosiderin | |
Ulcer | 3 |
__________________________________________________________________________|
Tongue | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 4 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|
DAY ON TEST | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|
| 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + M +|
Degeneration, Chronic | 3 3 1 3 2 2 1 2 1 3 2 2 2 2 2 2 2 2 2 2 2|
Mineralization | 3 |
Atrium, Thrombosis | X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 |
Hypertrophy | |
Vacuolization Cytoplasmic | 3 2 2 1 1 2 2 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2 1 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + M +|
Hyperplasia | 3 4 3 3 4 2 4 3 3 3 2 3 3 4 4 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
C-Cell, Hyperplasia | 2 2 2 2 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 2 2 2 2 2 2 2 2 2 1 2 2 1 2 3 2 2 2 2|
Duct, Ectasia | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 1 2 2 2 2 1 2 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 2 3 3 3 3 3 3 2|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 4 3 3 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|
DAY ON TEST | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|
| 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + +|
Pancreatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + +|
Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 1 2 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + M + + + + + + + M +|
Depletion Lymphoid | 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 3 3 3 3 3 3 1 2 3 2 3 1 2 2 3 3 2 3 3 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | |
__________________________________________________________________________|
Skin, Control | + + |
Acanthosis | 3 1 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | +|
Acanthosis | 1|
__________________________________________________________________________|
Skin, Site of Application-Mass | |
Cyst Epithelial Inclusion | |
Dermis, Fibrosis | |
Dermis, Mineralization | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | +|
__________________________________________________________________________|
Skin, Site of Application-Mass | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 3 2 2 |
Hemorrhage | 3 |
Hydrocephalus | 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + |
__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + M +|
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | 2 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|
DAY ON TEST | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|
| 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Chronic Active | 3 3 2 2 |
Sinus, Foreign Body | 3 2 2 2 |
Submucosa, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 4 4 2 4 4 2 4 4 4 4 4 4 2 4 3 4 4 4 4 2 4 4 4 3|
Cortex, Cyst | |
Cortex, Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 5| 4| 6| 7| 5| | |
DAY ON TEST | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6| | |
| 1| 1| 4| 5| 8| 3| 6| 7| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 2 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 6 |
Clear Cell Focus | X | 3 |
Eosinophilic Focus | | 4 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | | 6 |
Inflammation, Chronic Active | | 3 1.3|
Inflammation, Granulomatous | | 2 2.0|
Bile Duct, Hyperplasia | 2 3 3 2 1 2 1 2 2 | 37 2.1|
Hepatocyte, Degeneration, Cystic | | 4 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 | 22 2.2|
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Artery, Inflammation, Chronic Active | 4 | 1 4.0|
Fat, Hemorrhage | | 1 2.0|
Fat, Inflammation, Chronic Active | | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 2 2 3 | 23 2.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 10 |
Acanthosis | | 4 3.0|
Inflammation, Chronic Active | | 1 3.0|
Mineralization | | 1 2.0|
Ulcer | | 5 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 13 |
Dysplasia | | 2 2.0|
Mineralization | | 5 2.4|
Necrosis | | 1 2.0|
Pigmentation, Hemosiderin | | 1 1.0|
Ulcer | 2 | 4 2.5|
__________________________________________________________________________|____________|
Tongue | | 1 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Peridontal Tissue, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 5| 4| 6| 7| 5| | |
DAY ON TEST | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6| | |
| 1| 1| 4| 5| 8| 3| 6| 7| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Degeneration, Chronic | 2 1 2 1 2 1 2 2 2 1 | 51 1.9|
Mineralization | | 1 3.0|
Atrium, Thrombosis | X X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 29 |
Hyperplasia | 2 | 13 2.0|
Hypertrophy | 2 | 2 1.5|
Vacuolization Cytoplasmic | 2 3 | 22 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 27 |
Hyperplasia | 2 2 2 2 2 | 24 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 58 |
Hyperplasia | 3 3 2 3 | 37 2.9|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Cyst | X X | 7 |
Pars Distalis, Hyperplasia | 3 3 3 2 | 13 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | 2 2 2 | 12 2.0|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 2 3 2 1 2 2 2 | 46 2.0|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 1 2 2 4 4 2 | 30 2.1|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 5| 4| 6| 7| 5| | |
DAY ON TEST | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6| | |
| 1| 1| 4| 5| 8| 3| 6| 7| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Germinal Epithelium, Degeneration | | 16 2.7|
Interstitial Cell, Hyperplasia | 2 2 | 17 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Femoral, Myelofibrosis | | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 8 |
Pancreatic, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 13 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 9 |
Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 1 2 | 14 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 52 |
Depletion Lymphoid | 2 | 9 2.9|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + | 55 |
Hyperplasia, Cystic | 3 4 1 2 1 1 2 3 2 | 50 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | 3 | 3 3.0|
Hyperkeratosis | | 1 4.0|
__________________________________________________________________________|____________|
Skin, Control | | 3 |
Acanthosis | | 3 2.3|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | | 2 |
Acanthosis | | 1 1.0|
__________________________________________________________________________|____________|
Skin, Site of Application-Mass | + + + | 5 |
Cyst Epithelial Inclusion | | 1 |
Dermis, Fibrosis | 2 4 3 | 3 3.0|
Dermis, Mineralization | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | | 2 |
__________________________________________________________________________|____________|
Skin, Site of Application-Mass | + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 5| 4| 6| 7| 5| | |
DAY ON TEST | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6| | |
| 1| 1| 4| 5| 8| 3| 6| 7| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | 2 4 | 14 2.4|
Hemorrhage | | 1 3.0|
Hydrocephalus | 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 5 |
__________________________________________________________________________|____________|
Spinal Cord | | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Inflammation, Chronic Active | | 3 2.0|
Inflammation, Suppurative | | 1 2.0|
Mineralization | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Mucosa, Inflammation, Chronic Active | | 6 2.7|
Sinus, Foreign Body | | 6 2.3|
Submucosa, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 2 3.0|
Retina, Atrophy | | 2 3.5|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy, Chronic | 4 4 4 3 3 3 2 4 4 3 | 60 3.5|
Cortex, Cyst | X | 1 |
Cortex, Renal Tubule, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 5| 4| 5| 7| 3| 5| 2| 7| 6| 4| 7| 7| 6| 4| 6| 4| 6| 6| 4| 6| 7| 5| 6| 5| 4|
DAY ON TEST | 6| 6| 7| 3| 7| 4| 6| 1| 9| 5| 3| 3| 9| 5| 3| 5| 1| 3| 5| 3| 3| 9| 7| 4| 5|
| 4| 1| 9| 0| 9| 1| 4| 0| 1| 7| 0| 0| 8| 6| 8| 6| 2| 2| 6| 9| 0| 1| 0| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
.15 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 4 |
__________________________________________________________________________|
Skin, Control | + + |
Acanthosis | 2 1 |
Dermis, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 7| 4| 4| 6| 6| 5| 4| 4| 5| 7| 5| 6| 7| 6| 4| 7| 6| 7| 6| 7| 6| 7| 6| 5| 6|
DAY ON TEST | 2| 5| 7| 7| 2| 9| 5| 9| 7| 2| 7| 0| 3| 6| 5| 3| 9| 3| 7| 3| 5| 3| 5| 5| 2|
| 3| 6| 9| 5| 6| 3| 6| 9| 8| 2| 6| 6| 0| 8| 6| 0| 8| 1| 1| 1| 9| 1| 9| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.15 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
__________________________________________________________________________|
Skin, Control | + |
Acanthosis | 2 |
Dermis, Inflammation, Chronic | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 5| 6| 4| 6| | |
DAY ON TEST | 3| 2| 3| 1| 1| 1| 5| 1| 5| 2| | |
| 1| 1| 1| 2| 0| 2| 6| 6| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
.15 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 2 4.0|
__________________________________________________________________________|____________|
Skin, Control | | 3 |
Acanthosis | | 3 1.7|
Dermis, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 5| 6| 4| 6| | |
DAY ON TEST | 3| 2| 3| 1| 1| 1| 5| 1| 5| 2| | |
| 1| 1| 1| 2| 0| 2| 6| 6| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
.15 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 6| 4| 6| 7| 5| 5| 6| 4| 4| 6| 7| 6| 6| 5| 3| 7| 4| 6| 6| 4|
DAY ON TEST | 5| 0| 6| 8| 0| 4| 1| 7| 2| 2| 9| 6| 3| 5| 4| 1| 3| 9| 1| 6| 2| 5| 5| 4| 8|
| 6| 0| 4| 2| 7| 3| 6| 6| 9| 3| 9| 6| 7| 6| 8| 8| 2| 6| 1| 7| 9| 6| 5| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Skin, Control | |
Acanthosis | |
Hyperplasia, Basal Cell | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + |
Acanthosis | 1 1 1 1 |
Acanthosis, Multifocal | 1 |
__________________________________________________________________________|
Skin, Site of Application-Mass | + |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + |
Sebaceous Gland, Hyperplasia | 2 2 |
__________________________________________________________________________|
Skin, Site of Application-Mass | + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 6| 4| 6| 7| 5| 5| 6| 4| 4| 6| 7| 6| 6| 5| 3| 7| 4| 6| 6| 4|
DAY ON TEST | 5| 0| 6| 8| 0| 4| 1| 7| 2| 2| 9| 6| 3| 5| 4| 1| 3| 9| 1| 6| 2| 5| 5| 4| 8|
| 6| 0| 4| 2| 7| 3| 6| 6| 9| 3| 9| 6| 7| 6| 8| 8| 2| 6| 1| 7| 9| 6| 5| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 5| 4| 4| 5| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6| 0| 5| 7| 5| 6| 1| 6| 6| 6| 7| 7|
DAY ON TEST | 8| 5| 5| 8| 2| 2| 3| 3| 6| 7| 0| 2| 2| 1| 2| 3| 2| 2| 8| 9| 2| 0| 9| 2| 1|
| 7| 6| 6| 9| 9| 9| 5| 5| 2| 1| 5| 6| 7| 3| 5| 7| 9| 6| 3| 9| 1| 1| 8| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Skin, Control | + |
Acanthosis | 2 |
Hyperplasia, Basal Cell | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + |
Acanthosis | |
Acanthosis, Multifocal | |
__________________________________________________________________________|
Skin, Site of Application-Mass | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + |
Sebaceous Gland, Hyperplasia | 2 |
__________________________________________________________________________|
Skin, Site of Application-Mass | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 5| 4| 4| 5| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6| 0| 5| 7| 5| 6| 1| 6| 6| 6| 7| 7|
DAY ON TEST | 8| 5| 5| 8| 2| 2| 3| 3| 6| 7| 0| 2| 2| 1| 2| 3| 2| 2| 8| 9| 2| 0| 9| 2| 1|
| 7| 6| 6| 9| 9| 9| 5| 5| 2| 1| 5| 6| 7| 3| 5| 7| 9| 6| 3| 9| 1| 1| 8| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 6| 7| 5| 7| 7| 6| 6| | |
DAY ON TEST | 5| 3| 5| 6| 3| 7| 3| 3| 5| 1| | |
| 8| 2| 6| 3| 0| 5| 0| 0| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.5 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Hyperkeratosis | | 1 2.0|
__________________________________________________________________________|____________|
Skin, Control | + | 2 |
Acanthosis | | 1 2.0|
Hyperplasia, Basal Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + | 8 |
Acanthosis | 2 1 | 6 1.2|
Acanthosis, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Skin, Site of Application-Mass | + | 3 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + | 8 |
Sebaceous Gland, Hyperplasia | 1 | 4 1.8|
__________________________________________________________________________|____________|
Skin, Site of Application-Mass | + | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 6| 7| 5| 7| 7| 6| 6| | |
DAY ON TEST | 5| 3| 5| 6| 3| 7| 3| 3| 5| 1| | |
| 8| 2| 6| 3| 0| 5| 0| 0| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.5 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|
DAY ON TEST | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|
| 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + |
Dysplasia | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic Active | 1 |
Inflammation, Granulomatous | |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 3 2 4 1 4 2 2 2 2 2 2 2 3 2 2|
Hepatocyte, Degeneration, Cystic | 2 2 |
Hepatocyte, Hyperplasia | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 3 3 2 3 1 2 2 2 3|
__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation, Chronic Active | |
Fat, Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 3 2 2 1 2 2 2 2 3 2 2|
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + +|
Acanthosis | 3 |
Inflammation, Chronic Active | |
Mineralization | 4 |
Ulcer | 3 3 3 3 3 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
Hyperplasia | |
Mineralization | 4 2 |
Necrosis | 2 |
Ulcer | 3 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 3 2 3 2 2 2 1 3 2 1 3 2 1 1 2 2 1 2 1 1 2 |
Mineralization | 4 |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|
DAY ON TEST | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|
| 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + |
Hyperplasia | 2 |
Vacuolization Cytoplasmic | 2 2 2 2 2 3 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 3 2 2 2 4 2 3 4 3 4 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hemorrhage | 3 4 |
Pars Distalis, Hyperplasia | 2 2 3 |
Pars Distalis, Vacuolization | |
Cytoplasmic | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 2 2 2 2 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aspermia | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 2 4 3 2 2 1 2 1 2 3 2 2 2 |
Duct, Ectasia | 3 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 3 3 2 3 2 2 2 2 2 2 2 2 2 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Germinal Epithelium, Degeneration | 3 2 3 3 2 3 2 |
Interstitial Cell, Hyperplasia | 2 3 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|
DAY ON TEST | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|
| 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Myelofibrosis | 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Mediastinal, Congestion | |
Mediastinal, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 1 4 |
Infarct | |
Thrombosis | X |
Capsule, Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + M + + + M + + M + + + + + + + + + + + + +|
Depletion Lymphoid | 2 4 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + M + + + + + + + + + + + M +|
Hyperplasia, Cystic | 2 3 3 1 2 2 2 2 3 2 1 2 2 2 2 2 2 1 2 2|
Duct, Cyst | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | |
Hyperkeratosis | 4 |
Ulcer | 3 |
__________________________________________________________________________|
Skin, Control | |
Acanthosis | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + |
Acanthosis | 1 1 3 2 1 |
Cyst | |
__________________________________________________________________________|
Skin, Site of Application-Mass | + |
Cyst Epithelial Inclusion | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + |
Hyperkeratosis | 2 |
__________________________________________________________________________|
Skin, Site of Application-Mass | + |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + |
Ulcer | 1 |
__________________________________________________________________________|
Skin, Site of Application-Mass | + |
Dermis, Fibrosis | 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + |
Sebaceous Gland, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|
DAY ON TEST | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|
| 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Fracture | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 2 |
Hydrocephalus | 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Inflammation, Granulomatous | 2 |
Mineralization | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 3 |
Mucosa, Inflammation, Chronic Active | 3 3 2 3 3 |
Mucosa, Ulcer | 3 |
Sinus, Foreign Body | 1 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submucosa, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy, Chronic | 4 4 4 3 3 3 3 3 4 4 1 4 3 4 2 4 3 4 3 3 2 4 2 3 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|
DAY ON TEST | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|
| 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.5 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Small, Duodenum | |
Dysplasia | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X|
Clear Cell Focus | X X|
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic Active | |
Inflammation, Granulomatous | 2 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 3 2 2 3 2 2 3 2 3 2 1 2 2 3 2|
Hepatocyte, Degeneration, Cystic | 2 2 2 2 3 2|
Hepatocyte, Hyperplasia | |
Hepatocyte, Vacuolization Cytoplasmic| 2 3 2 3 4 2 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Artery, Inflammation, Chronic Active | |
Fat, Inflammation, Chronic Active | 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 1 2 2 2 1 2 2 1 1 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + |
Acanthosis | 3 |
Inflammation, Chronic Active | 2 3 |
Mineralization | 3 |
Ulcer | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + |
Hyperplasia | |
Mineralization | 3 |
Necrosis | 2 |
Ulcer | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 2 2 1 3 1 2 2 2 3 2 3 2 2 3 2 2 2 2|
Mineralization | 4 |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|
DAY ON TEST | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|
| 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.5 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + |
Hyperplasia | 2 2 2 2 |
Vacuolization Cytoplasmic | 2 2 2 2 2 2 2 1 4 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + +|
Hyperplasia | 4 3 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 4 2 3 3 2 2 3 4 3 4 2 3 3 2 3 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 3 3 3 2 |
Pars Distalis, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 2 2 2|
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aspermia | |
Inflammation, Granulomatous | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 2 4 2 2 3 4 2 2 2 2 2 2 2 2|
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Chronic Active | 2 2 2 1 2 4 2 1 3 |
Inflammation, Granulomatous | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Germinal Epithelium, Degeneration | 3 3 3 3 3 3 3 |
Interstitial Cell, Hyperplasia | 2 1 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|
DAY ON TEST | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|
| 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.5 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Myelofibrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Congestion | 3 |
Mediastinal, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Infarct | 4 |
Thrombosis | |
Capsule, Thrombosis | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + M|
Depletion Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + M + + M + + + M + + +|
Hyperplasia, Cystic | 2 2 3 3 3 3 3 2 3 2 2 2 2 3 2 2 3 2 2 2|
Duct, Cyst | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Cyst Epithelial Inclusion | |
Hyperkeratosis | |
Ulcer | |
__________________________________________________________________________|
Skin, Control | |
Acanthosis | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + |
Acanthosis | 1 1 1 3 2 |
Cyst | 1 |
__________________________________________________________________________|
Skin, Site of Application-Mass | + +|
Cyst Epithelial Inclusion | 2 X|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + |
Hyperkeratosis | |
__________________________________________________________________________|
Skin, Site of Application-Mass | + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + |
Ulcer | |
__________________________________________________________________________|
Skin, Site of Application-Mass | + +|
Dermis, Fibrosis | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + |
Sebaceous Gland, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
_____________________________________________________________________________________________________________________
| 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|
DAY ON TEST | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|
| 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.5 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Fracture | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 2 2 1 2 3 2 |
Hydrocephalus | 3 3 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Inflammation, Granulomatous | |
Mineralization | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | |
Mucosa, Inflammation, Chronic Active | 2 |
Mucosa, Ulcer | |
Sinus, Foreign Body | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submucosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Nephropathy, Chronic | 4 1 3 4 3 2 4 4 4 4 3 4 3 4 3 4 4 4 4 4 3 3 4 4 4|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 4| 3| 6| 7| 4| | |
DAY ON TEST | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2| | |
| 9| 9| 5| 4| 9| 6| 6| 0| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.5 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 3 |
Dysplasia | | 1 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X | 7 |
Clear Cell Focus | X | 3 |
Eosinophilic Focus | | 3 |
Hepatodiaphragmatic Nodule | X | 4 |
Inflammation, Chronic Active | 2 2 | 3 1.7|
Inflammation, Granulomatous | 1 2 | 3 1.7|
Bile Duct, Cyst | | 1 |
Bile Duct, Hyperplasia | 3 2 2 2 4 4 2 | 38 2.3|
Hepatocyte, Degeneration, Cystic | 2 | 9 2.1|
Hepatocyte, Hyperplasia | | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 | 21 2.3|
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Artery, Inflammation, Chronic Active | 4 | 1 4.0|
Fat, Inflammation, Chronic Active | 3 | 6 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 2 1 3 | 26 1.8|
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 13 |
Acanthosis | | 2 3.0|
Inflammation, Chronic Active | | 2 2.5|
Mineralization | | 2 3.5|
Ulcer | | 8 2.9|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 11 |
Hyperplasia | 2 | 1 2.0|
Mineralization | | 3 3.0|
Necrosis | | 2 2.0|
Ulcer | | 5 2.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 4| 3| 6| 7| 4| | |
DAY ON TEST | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2| | |
| 9| 9| 5| 4| 9| 6| 6| 0| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.5 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Degeneration, Chronic | 2 2 2 1 1 2 2 1 2 2 | 50 1.9|
Mineralization | | 2 4.0|
Atrium, Thrombosis | | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 24 |
Hyperplasia | 2 | 6 2.0|
Vacuolization Cytoplasmic | | 20 2.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 29 |
Hyperplasia | 2 2 2 2 2 | 21 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + | 58 |
Hyperplasia | 2 3 4 2 3 2 | 39 2.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Hemorrhage | | 2 3.5|
Pars Distalis, Hyperplasia | 2 3 2 4 | 11 2.6|
Pars Distalis, Vacuolization | | |
Cytoplasmic | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia | 2 | 11 1.9|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Aspermia | 3 3 | 2 3.0|
Inflammation, Granulomatous | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 | 38 2.2|
Duct, Ectasia | | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Hyperplasia | | 1 1.0|
Inflammation, Chronic Active | 2 1 2 | 26 2.1|
Inflammation, Granulomatous | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 4| 3| 6| 7| 4| | |
DAY ON TEST | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2| | |
| 9| 9| 5| 4| 9| 6| 6| 0| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.5 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Atrophy | 3 | 1 3.0|
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Cyst | | 1 |
Germinal Epithelium, Degeneration | 2 3 3 | 17 2.8|
Interstitial Cell, Hyperplasia | 2 2 2 | 13 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Femoral, Myelofibrosis | 2 | 4 2.8|
__________________________________________________________________________|____________|
Lymph Node | | 14 |
Mediastinal, Congestion | | 1 3.0|
Mediastinal, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 17 |
Infiltration Cellular, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 14 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 2 | 7 2.3|
Infarct | | 1 4.0|
Thrombosis | | 1 |
Capsule, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Thymus | + M + + M + M + M + | 51 |
Depletion Lymphoid | 2 2 | 7 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 53 |
Hyperplasia, Cystic | 2 2 1 3 2 2 3 3 2 | 49 2.2|
Duct, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 1 4.0|
Cyst Epithelial Inclusion | X | 1 |
Hyperkeratosis | | 1 4.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Skin, Control | + | 1 |
Acanthosis | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 4| 3| 6| 7| 4| | |
DAY ON TEST | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2| | |
| 9| 9| 5| 4| 9| 6| 6| 0| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.5 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + | 16 |
Acanthosis | 1 2 1 3 | 14 1.6|
Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Skin, Site of Application-Mass | + | 4 |
Cyst Epithelial Inclusion | | 2 2.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + | 16 |
Hyperkeratosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin, Site of Application-Mass | + | 4 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + | 16 |
Ulcer | | 1 1.0|
__________________________________________________________________________|____________|
Skin, Site of Application-Mass | + | 4 |
Dermis, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + | 16 |
Sebaceous Gland, Hyperplasia | 2 | 4 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Tarsal, Fracture | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | 2 2 | 13 2.2|
Hydrocephalus | 2 | 6 2.5|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 2 1.5|
Inflammation, Granulomatous | | 1 2.0|
Mineralization | | 2 3.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + M | 59 |
Lumen, Hemorrhage | | 1 3.0|
Mucosa, Inflammation, Chronic Active | | 6 2.7|
Mucosa, Ulcer | | 1 3.0|
Sinus, Foreign Body | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Submucosa, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05102-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZETHONIUM CHLORIDE Date: 04/23/97
Route: DERMAL,SOLUTION Time: 12:54:41
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 4| 3| 6| 7| 4| | |
DAY ON TEST | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2| | |
| 9| 9| 5| 4| 9| 6| 6| 0| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.5 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Lens, Cataract | 4 | 2 3.5|
Retina, Atrophy | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 |
Nephropathy, Chronic | 4 4 4 4 3 3 2 3 3 2 | 60 3.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
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---------- END OF REPORT ----------
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