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TDMS Study 05103-04 Pathology Tables

NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97
Route: DOSED FEED                                                                                                 Time: 17:12:59

                                                          CORE ANIMALS




       Facility:  Southern Research Institute

       Chemical CAS #:  3296-90-0

       Lock Date:  02/12/92

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25009 Missing
                               25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All
































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 0| 4| 8| 4| 4| 4| 4| 4| 4| 7|             
                                           | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 1| 5| 3| 4| 3| 3| 8| 3| 3| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                 X                 X  X   |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |    X     X              X        X     X                             X   |             
      Hepatocellular Adenoma, Multiple     |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                    +               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                      X  X                       X                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 0| 4| 8| 4| 4| 4| 4| 4| 4| 7|             
                                           | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 1| 5| 3| 4| 3| 3| 8| 3| 3| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                         X                                                |             
      Polyp Stromal                        |                            X                          X                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                                      +  +     +        +           +|             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                           +                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                            X        X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                              +                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                            X                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sebaceous Gland, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 0| 4| 8| 4| 4| 4| 4| 4| 4| 7|             
                                           | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 1| 5| 3| 4| 3| 3| 8| 3| 3| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                        +                                 |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                              X                 X         |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                 X                    X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +     +           +              +  +  +     +     +     +      |             
      Adenoma                              |                                           X                              |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                            X                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                         X                                                |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                            X        X                                    |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 2|             
                                           | 0| 6| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |             X                                                            |             
      Hepatocellular Carcinoma, Multiple   |                      X                                                   |             
      Hepatocellular Adenoma               |                X  X                    X  X                       X  X  X|             
      Hepatocellular Adenoma, Multiple     |                                                 X     X                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                    +                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                      +                                                   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                        X        X                 X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   5                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 2|             
                                           | 0| 6| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
      Bilateral, Adenoma                   |                                                       X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Polyp Stromal                        |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                             +                                       |             
      Mediastinal, Lymphoma Malignant Mixed|                                  X                                       |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |    X                                                                     |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sebaceous Gland, Carcinoma           |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   6                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 2|             
                                           | 0| 6| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                           +     +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                               X                 X                        |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         | X                                                                        |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |    X                                                                     |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                +     +        +  +  +        +      |             
      Adenoma                              |                                                    X                     |             
      Carcinoma                            |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   7                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4|                                                                    |            |
                             DAY ON TEST   | 8| 0|                                                                    |            |
                                           | 5| 7|                                                                    |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0|                                                                    |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0|                                                                    |     T      |
                               ANIMAL ID   | 2| 2|                                                                    |     A      |
    UNTREATD                               | 9| 9|                                                                    |     L      |
     CONTROL                               | 4| 8|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  A                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A                                                                     |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +                                                                     |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A                                                                     |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  A                                                                     |  51        |
      Hepatocellular Carcinoma             |                                                                          |          4 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |         13 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          3 |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  A                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +                                                                     |  52        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  A                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A                                                                     |  51        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                                                                     |  52        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  A                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  A                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A                                                                     |  51        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  A                                                                     |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  A                                                                     |  50        |
      Pars Distalis, Adenoma               |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A                                                                     |  51        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   8                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4|                                                                    |            |
                             DAY ON TEST   | 8| 0|                                                                    |            |
                                           | 5| 7|                                                                    |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0|                                                                    |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0|                                                                    |     T      |
                               ANIMAL ID   | 2| 2|                                                                    |     A      |
    UNTREATD                               | 9| 9|                                                                    |     L      |
     CONTROL                               | 4| 8|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Adenoma             |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +                                                                     |  51        |
      Adenoma                              |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Bilateral, Adenoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +                                                                     |  52        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +                                                                     |  52        |
      Hemangioma                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   9        |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Renal, Lymphoma Malignant Lymphocytic| X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  A                                                                     |  48        |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  A                                                                     |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  A                                                                     |  51        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  A                                                                     |  46        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   9                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4|                                                                    |            |
                             DAY ON TEST   | 8| 0|                                                                    |            |
                                           | 5| 7|                                                                    |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0|                                                                    |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0|                                                                    |     T      |
                               ANIMAL ID   | 2| 2|                                                                    |     A      |
    UNTREATD                               | 9| 9|                                                                    |     L      |
     CONTROL                               | 4| 8|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +                                                                     |  52        |
      Sebaceous Gland, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +                                                                     |  52        |
      Osteosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +                                                                     |  52        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  A                                                                     |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +                                                                     |  18        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  A                                                                     |  51        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A                                                                     |  51        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +                                                                     |  52        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4|                                                                    |            |
                             DAY ON TEST   | 8| 0|                                                                    |            |
                                           | 5| 7|                                                                    |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0|                                                                    |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0|                                                                    |     T      |
                               ANIMAL ID   | 2| 2|                                                                    |     A      |
    UNTREATD                               | 9| 9|                                                                    |     L      |
     CONTROL                               | 4| 8|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  11                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 3| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 4| 6| 9| 8| 4| 4| 4| 3| 4| 7| 0| 4| 6| 4| 4| 5| 1| 4| 4| 3| 7| 4| 4| 7| 4|             
                                           | 3| 8| 2| 6| 3| 3| 3| 5| 3| 7| 6| 3| 9| 3| 3| 5| 3| 3| 3| 0| 9| 3| 3| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0312%                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |    X  X                       X     X              X        X        X   |             
      Hepatocellular Adenoma               |             X           X                 X        X                     |             
      Hepatocellular Adenoma, Multiple     |                                        X                                X|             
      Histiocytic Sarcoma                  |                                           X                 X            |             
      Lymphoma Malignant Mixed             |          X     X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +  +                    +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |          X                                                               |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
      Sarcoma Stromal, Metastatic, Uterus  |                X                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
      Sarcoma Stromal, Metastatic, Uterus  |                X                                                         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  12                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 3| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 4| 6| 9| 8| 4| 4| 4| 3| 4| 7| 0| 4| 6| 4| 4| 5| 1| 4| 4| 3| 7| 4| 4| 7| 4|             
                                           | 3| 8| 2| 6| 3| 3| 3| 5| 3| 7| 6| 3| 9| 3| 3| 5| 3| 3| 3| 0| 9| 3| 3| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0312%                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
      Capsule, Carcinoma                   |                         X                                                |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                       X         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                   X                                X                     |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |             X                                                            |             
      Deciduoma Benign                     |                         X                                                |             
      Hemangioma                           |                      X                                                   |             
      Histiocytic Sarcoma                  |                                                             X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
      Polyp Adenomatous                    |                                                                          |             
      Polyp Stromal                        |                                                                          |             
      Sarcoma Stromal                      |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                             X            |             
      Lymphoma Malignant Mixed             |          X     X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +     +                                +        +               |             
      Axillary, Lymphoma Malignant Mixed   |          X                                                               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  13                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 3| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 4| 6| 9| 8| 4| 4| 4| 3| 4| 7| 0| 4| 6| 4| 4| 5| 1| 4| 4| 3| 7| 4| 4| 7| 4|             
                                           | 3| 8| 2| 6| 3| 3| 3| 5| 3| 7| 6| 3| 9| 3| 3| 5| 3| 3| 3| 0| 9| 3| 3| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0312%                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                 X                        |             
      Iliac, Lymphoma Malignant Mixed      |          X                                                               |             
      Iliac, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                 X                        |             
      Inguinal, Lymphoma Malignant Mixed   |          X                                                               |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                 X                        |             
      Mediastinal, Lymphoma Malignant Mixed|          X                                                               |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                 X                        |             
      Pancreatic, Lymphoma Malignant Mixed |          X     X                                                         |             
      Renal, Histiocytic Sarcoma           |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |          X                                                               |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |          X     X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                           X                 X            |             
      Lymphoma Malignant Mixed             |          X     X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
      Sarcoma Stromal, Metastatic, Uterus  |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |          +                                      +                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |          X     X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                          X               |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  14                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 3| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 4| 6| 9| 8| 4| 4| 4| 3| 4| 7| 0| 4| 6| 4| 4| 5| 1| 4| 4| 3| 7| 4| 4| 7| 4|             
                                           | 3| 8| 2| 6| 3| 3| 3| 5| 3| 7| 6| 3| 9| 3| 3| 5| 3| 3| 3| 0| 9| 3| 3| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0312%                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                                          |             
      Subcutaneous Tissue, Hemangioma      |                                                          X               |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                 +                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X           X                  |             
      Alveolar/Bronchiolar Carcinoma       |             X                                                            |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                   X  X                                                   |             
      Carcinoma, Metastatic, Adrenal Cortex|                         X                                                |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |    X                          X                                          |             
      Histiocytic Sarcoma                  |                                           X                 X            |             
      Lymphoma Malignant Mixed             |          X                                                               |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +     +     +  +  +        +  +        +     +  +  +     +  +  +  +|             
      Adenoma                              |                         X        X  X                    X     X         |             
      Carcinoma                            |             X     X  X                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |          X     X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  15                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 3| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 4| 6| 9| 8| 4| 4| 4| 3| 4| 7| 0| 4| 6| 4| 4| 5| 1| 4| 4| 3| 7| 4| 4| 7| 4|             
                                           | 3| 8| 2| 6| 3| 3| 3| 5| 3| 7| 6| 3| 9| 3| 3| 5| 3| 3| 3| 0| 9| 3| 3| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0312%                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                           X              X  X            |             
      Lymphoma Malignant Mixed             |          X     X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  16                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 4| 2| 4| 0| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4|            |
                                           | 7| 3| 3| 3| 3| 1| 9| 3| 3| 5| 6| 3| 7| 3| 8| 3| 3| 4| 4| 4| 4| 4| 6| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    0.0312%                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                                                 X                        |          8 |
      Hepatocellular Adenoma               | X                                   X        X                       X  X|          9 |
      Hepatocellular Adenoma, Multiple     |             X                                                            |          3 |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                X         |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |    X              X                                                      |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                            +                     |   6        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                            X              X                              |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          2 |
      Sarcoma Stromal, Metastatic, Uterus  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                    X                     |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          2 |
      Squamous Cell Papilloma              |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                            X              X                              |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          2 |
      Sarcoma Stromal, Metastatic, Uterus  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                   +      |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  17                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 4| 2| 4| 0| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4|            |
                                           | 7| 3| 3| 3| 3| 1| 9| 3| 3| 5| 6| 3| 7| 3| 8| 3| 3| 4| 4| 4| 4| 4| 6| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    0.0312%                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Carcinoma              |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Capsule, Carcinoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Benign              |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |          X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M|  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Pars Distalis, Adenoma               | X  X              X           X                 X           X            |          8 |
      Pars Intermedia, Adenoma             |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Adenoma             |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +              +                              |   2        |
      Lymphoma Malignant Mixed             |                            X              X                              |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |                                                                          |          1 |
      Deciduoma Benign                     |                                                                          |          1 |
      Hemangioma                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Polyp Adenomatous                    |                                                    X                     |          1 |
      Polyp Stromal                        |                                                          X               |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  18                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 4| 2| 4| 0| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4|            |
                                           | 7| 3| 3| 3| 3| 1| 9| 3| 3| 5| 6| 3| 7| 3| 8| 3| 3| 4| 4| 4| 4| 4| 6| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    0.0312%                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Sarcoma Stromal                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +  +     +  +           +        +           +         |  12        |
      Axillary, Lymphoma Malignant Mixed   |                            X                                   X         |          3 |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                            X              X                    X         |          4 |
      Iliac, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                   X                                                      |          2 |
      Inguinal, Lymphoma Malignant Mixed   |                            X                                   X         |          3 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                            X              X        X           X         |          5 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                            X              X                    X         |          5 |
      Renal, Histiocytic Sarcoma           |                      X                                                   |          1 |
      Renal, Lymphoma Malignant Mixed      |                            X              X                    X         |          4 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |                                           X  X     X           X         |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Histiocytic Sarcoma                  |                      X                                                   |          3 |
      Lymphoma Malignant Mixed             |                                           X        X           X         |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          2 |
      Sarcoma Stromal, Metastatic, Uterus  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                            +              +        +           +         |   6        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  19                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 4| 2| 4| 0| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4|            |
                                           | 7| 3| 3| 3| 3| 1| 9| 3| 3| 5| 6| 3| 7| 3| 8| 3| 3| 4| 4| 4| 4| 4| 6| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    0.0312%                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                            X              X  X     X           X         |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |    X              X                                                      |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                            X              X                    X         |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
      Squamous Cell Papilloma              |                                                                         X|          1 |
      Subcutaneous Tissue, Fibrous         |                                                                          |            |
          Histiocytoma                     | X                                                                        |          1 |
      Subcutaneous Tissue, Hemangioma      |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma,        |                                                                          |            |
          Multiple                         |                               X                                          |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |          3 |
      Alveolar/Bronchiolar Carcinoma       |             X                                                            |          2 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  20                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 4| 2| 4| 0| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4|            |
                                           | 7| 3| 3| 3| 3| 1| 9| 3| 3| 5| 6| 3| 7| 3| 8| 3| 3| 4| 4| 4| 4| 4| 6| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    0.0312%                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma, Metastatic, Adrenal Cortex|                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          2 |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                            X              X                    X         |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                +         |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +     +                 +  +  +     +     +        +     +         |  27        |
      Adenoma                              | X                                                                        |          6 |
      Carcinoma                            |                                  X  X                          X         |          6 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                    X           X         |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                           X                    X         |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                      X                                                   |          4 |
      Lymphoma Malignant Mixed             |                            X              X  X     X           X         |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |    X              X                                                      |          3 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  21                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 6| 1| 4| 9| 3| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| 2| 4| 7| 1| 4| 0| 4| 4| 4| 9|             
                                           | 9| 9| 4| 3| 9| 4| 5| 4| 0| 4| 4| 4| 3| 4| 4| 6| 4| 5| 1| 4| 9| 4| 4| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0625%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                X                                                         |             
      Hepatocellular Adenoma, Multiple     |                                                                X         |             
      Histiocytic Sarcoma                  |                                        X     X                           |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                X              X                                X         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                 +                                   +        +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                                               |             
      Yolk Sac Carcinoma, Metastatic, Ovary|                                                                         X|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                               X                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |    X                                      X                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  22                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 6| 1| 4| 9| 3| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| 2| 4| 7| 1| 4| 0| 4| 4| 4| 9|             
                                           | 9| 9| 4| 3| 9| 4| 5| 4| 0| 4| 4| 4| 3| 4| 4| 6| 4| 5| 1| 4| 9| 4| 4| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0625%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X              X                                                   |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                  X                          X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Luteoma                              |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                                               |             
      Yolk Sac Carcinoma                   |                                                                         X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                           X                              |             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +           +                             +                  |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |          X                                                               |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |          X                                                               |             
      Mediastinal, Sarcoma, Metastatic,    |                                                                          |             
           Skin                            | X                                                                        |             
      Pancreatic, Lymphoma Malignant Mixed |             X                                                            |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |          X                                                               |             
      Renal, Lymphoma Malignant Mixed      |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                               X                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  23                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 6| 1| 4| 9| 3| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| 2| 4| 7| 1| 4| 0| 4| 4| 4| 9|             
                                           | 9| 9| 4| 3| 9| 4| 5| 4| 0| 4| 4| 4| 3| 4| 4| 6| 4| 5| 1| 4| 9| 4| 4| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0625%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                        X     X                           |             
      Lymphoma Malignant Mixed             |             X  X                                               X         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +        +              +                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |             X                 X                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  I  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                               X                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Sarcoma         | X                                                           X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                            X                                             |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    M                                                                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |    +                          +                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X                                                           X     X   |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                             X            |             
      Alveolar/Bronchiolar Carcinoma       |                                  X                 X                     |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  24                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 6| 1| 4| 9| 3| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| 2| 4| 7| 1| 4| 0| 4| 4| 4| 9|             
                                           | 9| 9| 4| 3| 9| 4| 5| 4| 0| 4| 4| 4| 3| 4| 4| 6| 4| 5| 1| 4| 9| 4| 4| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0625%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma                  |                                        X     X                           |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                               X                                          |             
      Sarcoma, Metastatic, Skin            | X                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +        +                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +           +     +  +     +  +  +     +  +  +     +  +           +     +|             
      Adenoma                              |                               X           X  X     X                     |             
      Carcinoma                            |                      X                 X                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant Mixed             |                               X                                X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                        X     X                           |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |             X  X              X                                X         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                                               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  25                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 4| 6| 1| 4| 4| 4| 4| 2| 8| 5| 6| 3| 0| 4| 7| 4| 3| 5| 4| 4| 4| 4| 4| 3| 4|             
                                           | 4| 9| 8| 4| 4| 4| 4| 9| 3| 7| 9| 9| 7| 4| 9| 4| 3| 2| 4| 4| 4| 4| 4| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.0625%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |          X        X        X                          X     X            |             
      Hepatocellular Adenoma               |                                     X                 X        X         |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +        +        +                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Yolk Sac Carcinoma, Metastatic, Ovary|                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                  X                       X              X|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  26                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 4| 6| 1| 4| 4| 4| 4| 2| 8| 5| 6| 3| 0| 4| 7| 4| 3| 5| 4| 4| 4| 4| 4| 3| 4|             
                                           | 4| 9| 8| 4| 4| 4| 4| 9| 3| 7| 9| 9| 7| 4| 9| 4| 3| 2| 4| 4| 4| 4| 4| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.0625%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  I  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                                          |             
      Pars Distalis, Carcinoma             |          X                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                             X            |             
      Granulosa Cell Tumor Benign          |                               X                                          |             
      Luteoma                              |                                        X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Yolk Sac Carcinoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                             X            |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                                                                  |             
      Axillary, Lymphoma Malignant Mixed   |       X                                                                  |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |       X                                                                  |             
      Mediastinal, Lymphoma Malignant Mixed|       X                                                                  |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mediastinal, Sarcoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |       X                                                                  |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  27                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 4| 6| 1| 4| 4| 4| 4| 2| 8| 5| 6| 3| 0| 4| 7| 4| 3| 5| 4| 4| 4| 4| 4| 3| 4|             
                                           | 4| 9| 8| 4| 4| 4| 4| 9| 3| 7| 9| 9| 7| 4| 9| 4| 3| 2| 4| 4| 4| 4| 4| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.0625%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |       +                          +                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |       X  X                                   X                           |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Carcinoma                            |             X                                                            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Sarcoma         |                                                                      X  X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                      +                                                   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X                                         X  X              X         |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                         X|             
      Alveolar/Bronchiolar Carcinoma       |                X  X     X                                                |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  28                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 4| 6| 1| 4| 4| 4| 4| 2| 8| 5| 6| 3| 0| 4| 7| 4| 3| 5| 4| 4| 4| 4| 4| 3| 4|             
                                           | 4| 9| 8| 4| 4| 4| 4| 9| 3| 7| 9| 9| 7| 4| 9| 4| 3| 2| 4| 4| 4| 4| 4| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.0625%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |    X           X              X                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                             X            |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +        +  +     +     +  +     +  +        +     +  +        +      |             
      Adenoma                              |                      X     X                          X  X               |             
      Carcinoma                            |    X           X              X                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |       X  X                                   X                           |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  29                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |     T      |
                               ANIMAL ID   | 4|                                                                       |     A      |
    0.0625%                                | 1|                                                                       |     L      |
                                           | 3|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A                                                                        |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A                                                                        |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A                                                                        |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  50        |
      Hepatocellular Carcinoma             |                                                                          |          5 |
      Hepatocellular Adenoma               |                                                                          |          4 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Yolk Sac Carcinoma, Metastatic, Ovary|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | A                                                                        |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Squamous Cell Papilloma              |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  49        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  30                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |     T      |
                               ANIMAL ID   | 4|                                                                       |     A      |
    0.0625%                                | 1|                                                                       |     L      |
                                           | 3|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | A                                                                        |  49        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  48        |
      Pars Distalis, Adenoma               |                                                                          |          2 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      Follicular Cell, Adenoma             |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  51        |
      Adenoma                              |                                                                          |          1 |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Luteoma                              |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Yolk Sac Carcinoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  51        |
      Carcinoma                            |                                                                          |          2 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  31                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |     T      |
                               ANIMAL ID   | 4|                                                                       |     A      |
    0.0625%                                | 1|                                                                       |     L      |
                                           | 3|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mediastinal, Sarcoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          2 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M                                                                        |  46        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  50        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
      Osteosarcoma                         |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  32                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |     T      |
                               ANIMAL ID   | 4|                                                                       |     A      |
    0.0625%                                | 1|                                                                       |     L      |
                                           | 3|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          7 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          5 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         | X                                                                        |          1 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          3 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  27        |
      Adenoma                              |                                                                          |          8 |
      Carcinoma                            |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  33                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |     T      |
                               ANIMAL ID   | 4|                                                                       |     A      |
    0.0625%                                | 1|                                                                       |     L      |
                                           | 3|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  34                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 5| 5| 6| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 5| 5| 7| 4| 4| 5| 6| 6| 4|             
                             DAY ON TEST   | 6| 4| 7| 3| 7| 0| 7| 3| 1| 4| 6| 7| 1| 4| 5| 6| 3| 3| 4| 5| 8| 2| 5| 6| 9|             
                                           | 9| 9| 2| 7| 5| 6| 6| 3| 0| 4| 9| 4| 9| 2| 4| 8| 4| 4| 4| 6| 3| 0| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Sarcoma, Metastatic, Mesentery       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                        X                                 |             
      Hepatocellular Carcinoma, Multiple   |                      X                                                   |             
      Hepatocellular Adenoma               | X                          X  X                                   X      |             
      Hepatocellular Adenoma, Multiple     |                                                       X                  |             
      Histiocytic Sarcoma                  |                         X                                                |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma, Metastatic, Mesentery       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +           +     +        +     +                        |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Sarcoma                              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Mesentery       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
      Pars Distalis, Adenoma               |          X  X                    X                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  35                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 5| 5| 6| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 5| 5| 7| 4| 4| 5| 6| 6| 4|             
                             DAY ON TEST   | 6| 4| 7| 3| 7| 0| 7| 3| 1| 4| 6| 7| 1| 4| 5| 6| 3| 3| 4| 5| 8| 2| 5| 6| 9|             
                                           | 9| 9| 2| 7| 5| 6| 6| 3| 0| 4| 9| 4| 9| 2| 4| 8| 4| 4| 4| 6| 3| 0| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Granulosa Cell Tumor Benign          |                                              X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Hemangiosarcoma                      |       X                                                                  |             
      Polyp Stromal                        |                      X                                                   |             
      Sarcoma Stromal                      |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +     +        +                                             |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                            X                                             |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
      Renal, Sarcoma, Metastatic, Skin     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                         X                                                |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |             +                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  M  M  +  M  +  +  +  I  M  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma, Metastatic, Mesentery       |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoacanthoma                       |                                                          X               |             
      Carcinoma                            |                                        X                       X         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  36                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 5| 5| 6| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 5| 5| 7| 4| 4| 5| 6| 6| 4|             
                             DAY ON TEST   | 6| 4| 7| 3| 7| 0| 7| 3| 1| 4| 6| 7| 1| 4| 5| 6| 3| 3| 4| 5| 8| 2| 5| 6| 9|             
                                           | 9| 9| 2| 7| 5| 6| 6| 3| 0| 4| 9| 4| 9| 2| 4| 8| 4| 4| 4| 6| 3| 0| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Carcinoma, Multiple                  |                   X                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                     X                                    |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |          X     X     X        X                 X                 X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                    X                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X        X                       X  X        X     X              X      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                            X                                             |             
      Alveolar/Bronchiolar Carcinoma       | X                                   X                                    |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                      X                                                   |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
      Carcinoma, Metastatic, Mammary Gland |                   X                                                      |             
      Histiocytic Sarcoma                  |                         X                                                |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                    +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +        +  +  +        +  +  +  +  +  +  +        +        +  +  +  +|             
      Adenoma                              | X           X  X              X     X  X              X                  |             
      Carcinoma                            |             X  X                                                  X  X   |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  37                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 5| 5| 6| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 5| 5| 7| 4| 4| 5| 6| 6| 4|             
                             DAY ON TEST   | 6| 4| 7| 3| 7| 0| 7| 3| 1| 4| 6| 7| 1| 4| 5| 6| 3| 3| 4| 5| 8| 2| 5| 6| 9|             
                                           | 9| 9| 2| 7| 5| 6| 6| 3| 0| 4| 9| 4| 9| 2| 4| 8| 4| 4| 4| 6| 3| 0| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                         X                                                |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  38                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 5| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 4| 5| 4| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 6| 5| 6| 4| 6| 4| 4| 4| 6| 0| 4| 4| 2| 5| 8| 8| 0| 1| 4| 4| 4| 4| 4|            |
                                           | 7| 7| 9| 1| 7| 4| 9| 4| 4| 9| 9| 2| 4| 4| 6| 1| 0| 6| 1| 5| 4| 9| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    0.125%                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  I|  45        |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangioma                           |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Carcinoma, Multiple   |                                                                         X|          2 |
      Hepatocellular Adenoma               |    X     X     X           X                    X           X  X  X     X|         13 |
      Hepatocellular Adenoma, Multiple     |                   X     X                                                |          3 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                X                       X                                 |          2 |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   6        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Papilloma              | X                                      X                    X            |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Sarcoma, Metastatic, Skin            |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  39                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 5| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 4| 5| 4| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 6| 5| 6| 4| 6| 4| 4| 4| 6| 0| 4| 4| 2| 5| 8| 8| 0| 1| 4| 4| 4| 4| 4|            |
                                           | 7| 7| 9| 1| 7| 4| 9| 4| 4| 9| 9| 2| 4| 4| 6| 1| 0| 6| 1| 5| 4| 9| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    0.125%                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  46        |
      Pars Distalis, Adenoma               |                                        X     X                           |          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Carcinoma                            |             X                                                            |          1 |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |             X                                            X               |          2 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          1 |
      Sarcoma Stromal                      |                                                          X               |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      | X                                                                        |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +           +           +              +  +        +                  |   9        |
      Iliac, Lymphoma Malignant Mixed      |                X                                                         |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                X                                                         |          1 |
      Renal, Lymphoma Malignant Mixed      |                X                                                         |          1 |
      Renal, Sarcoma, Metastatic, Skin     |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                            +                          +                  |   3        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  40                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 5| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 4| 5| 4| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 6| 5| 6| 4| 6| 4| 4| 4| 6| 0| 4| 4| 2| 5| 8| 8| 0| 1| 4| 4| 4| 4| 4|            |
                                           | 7| 7| 9| 1| 7| 4| 9| 4| 4| 9| 9| 2| 4| 4| 6| 1| 0| 6| 1| 5| 4| 9| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    0.125%                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemangioma                           |                                                                X         |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|  42        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                X                                                         |          1 |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Adenoacanthoma                       |                                                                          |          1 |
      Carcinoma                            |                                                                          |          2 |
      Carcinoma, Multiple                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Papilloma              |                X                                                         |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma | X                                                                 X      |          2 |
      Subcutaneous Tissue, Sarcoma         |                            X                 X  X           X  X         |         11 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                 +                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         | X  X           X        X  X                             X  X  X         |         15 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                    X                     |          2 |
      Alveolar/Bronchiolar Carcinoma       |                         X                                         X      |          4 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  41                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 5| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 4| 5| 4| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 6| 5| 6| 4| 6| 4| 4| 4| 6| 0| 4| 4| 2| 5| 8| 8| 0| 1| 4| 4| 4| 4| 4|            |
                                           | 7| 7| 9| 1| 7| 4| 9| 4| 4| 9| 9| 2| 4| 4| 6| 1| 0| 6| 1| 5| 4| 9| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    0.125%                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma, Metastatic, Mammary Gland |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Sarcoma, Metastatic, Skin            |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +  +              +  +  +                                          |   7        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +  +  +     +  +     +  +  +        +           +  +  +  +  +  +     +|  33        |
      Adenoma                              |          X              X  X  X                    X           X  X      |         14 |
      Carcinoma                            |       X           X                                            X         |          7 |
      Bilateral, Adenoma                   |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |          +                                                               |   1        |
      Carcinoma                            |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                X                       X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                X                    X  X                                 |          3 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  42                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7|             
                                           | 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma                   |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             | X        X  X                             X                             X|             
      Hepatocellular Adenoma               |    X           X     X                          X     X  X     X         |             
      Hepatocellular Adenoma, Multiple     |          X                             X           X                 X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +                 +  +                 +        +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Carcinoma           |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                    +                     |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  43                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7|             
                                           | 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                  +  +                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  A  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                               X  X        X  X     X           X        X|             
      Alveolar/Bronchiolar Carcinoma       |                                        X        X                        |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +        +     +     +  +  +                 +     +           +     +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  44                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7|             
                                           | 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                    +                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  45                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 9| 6| 6| 6| 6| 6| 4| 6| 9| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cholangiocarcinoma                   |          X                                                               |          1 |
      Hemangiosarcoma                      |    X                                                                     |          1 |
      Hepatocellular Carcinoma             |       X  X              X     X        X  X                              |         11 |
      Hepatocellular Adenoma               |          X        X                                      X     X     X   |         12 |
      Hepatocellular Adenoma, Multiple     |    X        X                                                            |          6 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                   +     +|   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +        +        +                          +           +  +     +  +|  13        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  48        |
      Capsule, Adenoma                     |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  46                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 9| 6| 6| 6| 6| 6| 4| 6| 9| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |    +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Mixed             |                                  X                                   X   |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                   X        X     X                    X        X         |         12 |
      Alveolar/Bronchiolar Carcinoma       |    X                                                                     |          3 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                           X                              |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                         X     X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  47                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 9| 6| 6| 6| 6| 6| 4| 6| 9| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +  +  +  +  +  +  +     +     +  +     +                 +            |  22        |
      Adenoma                              |                                  X  X                       X            |          3 |
      Carcinoma                            |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                  X                                   X   |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  48                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 2| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0312%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  M  +|             
      Fibrous Histiocytoma                 |                                                                          |             
      Hepatoblastoma, Metastatic, Liver    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |             X                                                            |             
      Hemangiosarcoma                      |       X                                                           X      |             
      Hepatoblastoma                       |                                                                          |             
      Hepatocellular Carcinoma             |             X           X           X  X     X        X  X        X     X|             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |                   X  X        X     X  X           X                 X  X|             
      Hepatocellular Adenoma, Multiple     |    X  X                                               X                  |             
      Histiocytic Sarcoma                  |                                                 X                        |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Hepatoblastoma, Metastatic, Liver    |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                 X                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                                 +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
      Histiocytic Sarcoma                  |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  49                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 2| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0312%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  I  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |    X                                                  X  X               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                +                                                         |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                           X                       X      |             
      Histiocytic Sarcoma                  |                                                 X                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                    +                     |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Iliac, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Popliteal, Lymphoma Malignant        |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  50                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 2| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0312%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                 X                        |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                           X                       X      |             
      Histiocytic Sarcoma                  |                                                 X                        |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Squamous Cell Papilloma              |                X                                                         |             
      Sebaceous Gland, Adenoma             |                               X                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X                                         X                  |             
      Alveolar/Bronchiolar Carcinoma       |                   X                                X                     |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  51                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 2| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0312%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hepatoblastoma, Metastatic, Liver    |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |             X                                X           X               |             
      Histiocytic Sarcoma                  |                                                 X                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +     +  +     +  +        +  +  +  +  +           +               |             
      Adenoma                              | X              X                                         X               |             
      Carcinoma                            |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                 X                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                 X                        |             
      Lymphoma Malignant Mixed             |                                                       X           X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  52                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 6| 4| 7| 4| 3| 3| 0| 2| 3| 8| 3| 3| 3|             
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 3| 8| 6| 7| 7| 5| 5| 7| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0312%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|             
      Fibrous Histiocytoma                 |                                           X                              |             
      Hepatoblastoma, Metastatic, Liver    |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatoblastoma                       |                                           X                              |             
      Hepatocellular Carcinoma             |                      X           X     X                 X  X           X|             
      Hepatocellular Carcinoma, Multiple   |                            X              X                              |             
      Hepatocellular Adenoma               |    X  X           X                 X           X  X  X                  |             
      Hepatocellular Adenoma, Multiple     |                         X                                               X|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                    +         |             
      Hepatoblastoma, Metastatic, Liver    |                                           X                              |             
      Histiocytic Sarcoma                  |                                                                X         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                      X                                               X   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                          X               |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  53                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 6| 4| 7| 4| 3| 3| 0| 2| 3| 8| 3| 3| 3|             
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 3| 8| 6| 7| 7| 5| 5| 7| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0312%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |       X                                                                  |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                      +   |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                      +   |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                                      X   |             
      Iliac, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                      X   |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                                      X   |             
      Popliteal, Lymphoma Malignant        |                                                                          |             
          Undifferentiated Cell Type       |                                                                      X   |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  54                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 6| 4| 7| 4| 3| 3| 0| 2| 3| 8| 3| 3| 3|             
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 3| 8| 6| 7| 7| 5| 5| 7| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0312%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                    X                     |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
      Squamous Cell Papilloma              |                                                                          |             
      Sebaceous Gland, Adenoma             |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                          X               |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                    X           X         |             
      Alveolar/Bronchiolar Carcinoma       |       X     X           X                    X                           |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  55                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 6| 4| 7| 4| 3| 3| 0| 2| 3| 8| 3| 3| 3|             
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 3| 8| 6| 7| 7| 5| 5| 7| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0312%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hepatoblastoma, Metastatic, Liver    |                                           X                              |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                      X                                   X               |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                +                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +              +  +  +  +  +           +  +     +        +         |             
      Adenoma                              | X                                X                    X                  |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      | X                                                                        |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  56                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 2|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE MALE                        | 0|                                                                       |     T      |
                               ANIMAL ID   | 1|                                                                       |     A      |
    0.0312%                                | 1|                                                                       |     L      |
                                           | 6|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M                                                                        |  44        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Hepatoblastoma, Metastatic, Liver    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | M                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Hemangioma                           |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          2 |
      Hepatoblastoma                       |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |         15 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          2 |
      Hepatocellular Adenoma               |                                                                          |         15 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          5 |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Hepatoblastoma, Metastatic, Liver    |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  51        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Squamous Cell Papilloma              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  57                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 2|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE MALE                        | 0|                                                                       |     T      |
                               ANIMAL ID   | 1|                                                                       |     A      |
    0.0312%                                | 1|                                                                       |     L      |
                                           | 6|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
      Adenoma                              |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  50        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M                                                                        |  46        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      Follicular Cell, Adenoma             |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +                                                                        |  51        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
      Hemangiosarcoma                      |                                                                          |          2 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   3        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  58                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 2|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE MALE                        | 0|                                                                       |     T      |
                               ANIMAL ID   | 1|                                                                       |     A      |
    0.0312%                                | 1|                                                                       |     L      |
                                           | 6|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Iliac, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Popliteal, Lymphoma Malignant        |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  49        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  49        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
      Hemangiosarcoma                      |                                                                          |          3 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Sebaceous Gland, Adenoma             |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  59                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 2|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE MALE                        | 0|                                                                       |     T      |
                               ANIMAL ID   | 1|                                                                       |     A      |
    0.0312%                                | 1|                                                                       |     L      |
                                           | 6|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          4 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          6 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Hepatoblastoma, Metastatic, Liver    |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          5 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |  25        |
      Adenoma                              |                                                                          |          6 |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  60                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 2|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE MALE                        | 0|                                                                       |     T      |
                               ANIMAL ID   | 1|                                                                       |     A      |
    0.0312%                                | 1|                                                                       |     L      |
                                           | 6|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  61                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0625%                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |          X  X     X  X  X                 X                             X|             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               | X                 X  X  X           X        X        X           X      |             
      Hepatocellular Adenoma, Multiple     |    X  X                                                  X     X     X   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                    +                     |             
      Squamous Cell Papilloma              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                   X                                                      |             
      Squamous Cell Papilloma              |                                     X                          X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +        +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                             X            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  62                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0625%                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                +         |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             | X                                               X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Sarcoma         |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X  X              X              X                                 |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                       X                  |             
      Alveolar/Bronchiolar Carcinoma       |    X                    X              X                                 |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  63                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0625%                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Liver                           |          X                                X                             X|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +  +  +  +        +  +  +  +  +     +     +  +     +        +      |             
      Adenoma                              |                            X     X        X     X                 X      |             
      Carcinoma                            |       X                 X                                                |             
      Bilateral, Adenoma                   |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Renal Tubule, Adenoma                |                X                       X                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             | X                                               X                        |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  64                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 0| 7| 7| 7| 6| 5| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 6| 8| 3| 3| 6| 3| 3| 7| 3| 3| 6| 3| 4| 3| 3| 3| 6| 3| 3| 6| 3| 6| 6|            |
                                           | 7| 8| 9| 7| 8| 8| 2| 8| 8| 2| 8| 8| 9| 8| 5| 8| 8| 8| 9| 6| 8| 8| 8| 6| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    0.0625%                                | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Mixed             |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Mixed             |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Hepatocellular Carcinoma             |          X     X  X           X     X           X              X         |         14 |
      Hepatocellular Carcinoma, Multiple   |                                                                      X   |          1 |
      Hepatocellular Adenoma               |    X     X                          X                                    |         11 |
      Hepatocellular Adenoma, Multiple     |                               X                          X     X         |          8 |
      Lymphoma Malignant Mixed             |                   X                                               X      |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                                            +            |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  65                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 0| 7| 7| 7| 6| 5| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 6| 8| 3| 3| 6| 3| 3| 7| 3| 3| 6| 3| 4| 3| 3| 3| 6| 3| 3| 6| 3| 6| 6|            |
                                           | 7| 8| 9| 7| 8| 8| 2| 8| 8| 2| 8| 8| 9| 8| 5| 8| 8| 8| 9| 6| 8| 8| 8| 6| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    0.0625%                                | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +        +        +                                      +      |   5        |
      Iliac, Lymphoma Malignant Mixed      |                   X                                                      |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                   X                                                      |          1 |
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                            X                                             |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                   X                                               X      |          2 |
      Pancreatic, Lymphoma Malignant Mixed |          X                                                               |          1 |
      Renal, Lymphoma Malignant Mixed      |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                   X                                               X      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                   X                                            X  X      |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                   +        +                                      +      |   3        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |          X        X                                               X      |          4 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  M  +  M  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +|  40        |
      Lymphoma Malignant Mixed             |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Sarcoma         |                                                                   X      |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  66                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 0| 7| 7| 7| 6| 5| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 6| 8| 3| 3| 6| 3| 3| 7| 3| 3| 6| 3| 4| 3| 3| 3| 6| 3| 3| 6| 3| 6| 6|            |
                                           | 7| 8| 9| 7| 8| 8| 2| 8| 8| 2| 8| 8| 9| 8| 5| 8| 8| 8| 9| 6| 8| 8| 8| 6| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    0.0625%                                | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         | X                       X  X  X                                          |          8 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                  X                       X        X      |          4 |
      Alveolar/Bronchiolar Carcinoma       |       X                    X  X        X                             X   |          8 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          3 |
      Lymphoma Malignant Mixed             |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +        +                             +  +                  |   4        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +     +     +  +     +     +     +  +           +     +           +  +  +|  28        |
      Adenoma                              |       X     X        X                                X           X     X|         11 |
      Carcinoma                            |                                     X                                X   |          4 |
      Bilateral, Adenoma                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                X         |          1 |
      Renal Tubule, Adenoma                |                                     X                                    |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |          X        X                                            X  X      |          6 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  67                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 7| 5| 7| 6| 4| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 2|             
                             DAY ON TEST   | 6| 3| 3| 8| 0| 3| 9| 3| 6| 4| 3| 6| 3| 2| 3| 6| 9| 2| 3| 3| 3| 1| 3| 3| 4|             
                                           | 9| 8| 8| 9| 3| 8| 2| 8| 9| 5| 8| 5| 8| 5| 8| 9| 3| 5| 8| 8| 8| 5| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.125%                                 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Carcinoma                            |                                              X                           |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                X                                                         |             
      Hepatocellular Carcinoma             |                      X                 X        X              X     X   |             
      Hepatocellular Adenoma               |       X     X        X           X                 X        X            |             
      Hepatocellular Adenoma, Multiple     |          X                                      X                        |             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                      X                       X                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                       +                           |             
      Hemangiosarcoma                      |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                              X                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Squamous Cell Carcinoma              |                      X                       X                           |             
      Squamous Cell Papilloma              |                                                             X            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                +         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  68                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 7| 5| 7| 6| 4| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 2|             
                             DAY ON TEST   | 6| 3| 3| 8| 0| 3| 9| 3| 6| 4| 3| 6| 3| 2| 3| 6| 9| 2| 3| 3| 3| 1| 3| 3| 4|             
                                           | 9| 8| 8| 9| 3| 8| 2| 8| 9| 5| 8| 5| 8| 5| 8| 9| 3| 5| 8| 8| 8| 5| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.125%                                 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +  +                                                   |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                X                                                         |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                X                                                         |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  69                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 7| 5| 7| 6| 4| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 2|             
                             DAY ON TEST   | 6| 3| 3| 8| 0| 3| 9| 3| 6| 4| 3| 6| 3| 2| 3| 6| 9| 2| 3| 3| 3| 1| 3| 3| 4|             
                                           | 9| 8| 8| 9| 3| 8| 2| 8| 9| 5| 8| 5| 8| 5| 8| 9| 3| 5| 8| 8| 8| 5| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.125%                                 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                      +                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  I  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mast Cell Tumor Benign               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                               X     X     X        X  X                  |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         | X                                            X  X                        |             
      Alveolar/Bronchiolar Carcinoma       |                      X        X           X                              |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                    X                     |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  70                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 7| 5| 7| 6| 4| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 2|             
                             DAY ON TEST   | 6| 3| 3| 8| 0| 3| 9| 3| 6| 4| 3| 6| 3| 2| 3| 6| 9| 2| 3| 3| 3| 1| 3| 3| 4|             
                                           | 9| 8| 8| 9| 3| 8| 2| 8| 9| 5| 8| 5| 8| 5| 8| 9| 3| 5| 8| 8| 8| 5| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.125%                                 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                      X                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                    +                          +        +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +     +  +  +     +  +        +     +     +     +  +  +  +        +  +|             
      Adenoma                              | X  X           X                             X           X               |             
      Carcinoma                            |          X              X                                   X            |             
      Bilateral, Adenoma                   |                                  X     X                             X   |             
      Bilateral, Carcinoma                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                      X                                                   |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  71                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|  |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 4| 3| 3| 3| 3|  |            |
                                           | 7| 8| 8| 8| 8| 8| 9| 8| 2| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 1| 8| 8| 8| 8|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|  |     A      |
    0.125%                                 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|  |     L      |
                                           | 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  M  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  I  +  +  +  +  +  +  +  +   |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +   |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Lymphoma Malignant Mixed             |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Carcinoma                            |                                                    X                     |          2 |
      Lymphoma Malignant Mixed             |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                          X               |          1 |
      Hemangioma                           |                X                                                         |          1 |
      Hemangiosarcoma                      |                                                             X            |          2 |
      Hepatocellular Carcinoma             |                                           X                       X      |          7 |
      Hepatocellular Adenoma               | X  X                                X                 X                  |         10 |
      Hepatocellular Adenoma, Multiple     |       X        X        X  X           X           X              X      |          9 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                     X                                    |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   3        |
      Hemangiosarcoma                      |                X                                                         |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Squamous Cell Carcinoma              |                                                                          |          2 |
      Squamous Cell Papilloma              |                                     X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                          X               |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  72                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|  |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 4| 3| 3| 3| 3|  |            |
                                           | 7| 8| 8| 8| 8| 8| 9| 8| 2| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 1| 8| 8| 8| 8|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|  |     A      |
    0.125%                                 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|  |     L      |
                                           | 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +              +                                                   |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Adenoma                              |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Pars Distalis, Carcinoma             | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Follicular Cell, Adenoma             |                   X                                X        X            |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                          X               |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hemangioma                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  73                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|  |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 4| 3| 3| 3| 3|  |            |
                                           | 7| 8| 8| 8| 8| 8| 9| 8| 2| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 1| 8| 8| 8| 8|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|  |     A      |
    0.125%                                 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|  |     L      |
                                           | 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +           +           +                                    |   6        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Axillary, Lymphoma Malignant Mixed   |                         X                                                |          1 |
      Iliac, Lymphoma Malignant Mixed      |                         X                                                |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                         X                                                |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                     X                                    |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                         X                                                |          1 |
      Renal, Lymphoma Malignant Mixed      |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  I  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +   |  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                         X           X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                     +                                    |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                         X     X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +   |  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Mast Cell Tumor Benign               |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                          +               |   1        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  74                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|  |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 4| 3| 3| 3| 3|  |            |
                                           | 7| 8| 8| 8| 8| 8| 9| 8| 2| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 1| 8| 8| 8| 8|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|  |     A      |
    0.125%                                 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|  |     L      |
                                           | 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Metastatic, Lung                 |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Alveolar/Bronchiolar Adenoma         |    X           X  X  X              X                          X         |         11 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |          X  X              X  X  X           X     X                     |         10 |
      Alveolar/Bronchiolar Carcinoma       |                X           X     X     X                       X         |          8 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                   X                                      X           X   |          3 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                           X                       X      |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +              +                          +  +     +                  |   9        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +  +  +  +     +  +        +        +  +  +  +     +  +     +  +  +   |  32        |
      Adenoma                              |             X     X                    X        X     X                  |         10 |
      Carcinoma                            |                                                                          |          3 |
      Bilateral, Adenoma                   |    X     X                                   X           X        X      |          8 |
      Bilateral, Carcinoma                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                             +            |   1        |
      Carcinoma                            |                                                             X            |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                          X               |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
      Renal Tubule, Adenoma                |          X                                                     X         |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  75                                                               
NTP Experiment-Test: 05103-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 17:12:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|  |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 4| 3| 3| 3| 3|  |            |
                                           | 7| 8| 8| 8| 8| 8| 9| 8| 2| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 1| 8| 8| 8| 8|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|  |     A      |
    0.125%                                 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|  |     L      |
                                           | 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hemangiosarcoma                      |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                         X     X     X                                    |          3 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  76                                                               
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