TDMS Study 05103-04 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL
NTP Experiment-Test: 05103-04 Report: PEIRPT03
Study Type: CHRONIC Date: 05/19/95
Route: DOSED FEED Time: 19:06:50
Facility: Southern Research Institute
Chemical CAS #: 3296-90-0
Lock Date: 02/12/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05103-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:06:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.0312% 0.0625% 0.125%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 8 10 9 10
Early Deaths
Moribund Sacrifice 9 14 14 29
Natural Death 6 6 11 10
Survivors
Terminal Sacrifice 37 30 26 11
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (59) (59) (59) (58)
Mucosa, Hyperplasia 1 (2%)
Gallbladder (56) (57) (55) (55)
Dilatation 2 (4%) 1 (2%)
Intestine Large, Cecum (60) (60) (58) (60)
Edema 3 (5%) 1 (2%) 4 (7%) 4 (7%)
Intestine Small, Duodenum (59) (60) (56) (59)
Ulcer 1 (2%)
Intestine Small, Jejunum (57) (59) (58) (57)
Peyer's Patch, Hyperplasia 1 (2%)
Intestine Small, Ileum (59) (60) (56) (57)
Amyloid Deposition 1 (2%)
Liver (59) (60) (59) (59)
Basophilic Focus 1 (2%) 4 (7%) 2 (3%) 2 (3%)
Clear Cell Focus 1 (2%)
Cyst 1 (2%)
Degeneration, Fatty 1 (2%) 1 (2%) 3 (5%)
Developmental Malformation 1 (2%) 1 (2%)
Eosinophilic Focus 4 (7%) 2 (3%) 3 (5%) 6 (10%)
Hematopoietic Cell Proliferation 9 (15%) 6 (10%) 4 (7%) 15 (25%)
Hyperplasia, Lymphoid 3 (5%) 1 (2%) 1 (2%) 2 (3%)
Inflammation, Subacute 7 (12%) 3 (5%) 2 (3%) 2 (3%)
Mixed Cell Focus 1 (2%) 2 (3%) 3 (5%) 1 (2%)
Centrilobular, Necrosis 1 (2%) 2 (3%) 2 (3%)
Kupffer Cell, Hyperplasia 6 (10%) 4 (7%) 7 (12%) 12 (20%)
Kupffer Cell, Pigmentation 2 (3%) 1 (2%) 1 (2%)
Lobules, Necrosis 4 (7%) 7 (12%) 6 (10%) 6 (10%)
Mesentery (4) (7) (8) (8)
Inflammation, Chronic 2 (25%)
Fat, Necrosis 4 (100%) 6 (86%) 4 (50%) 7 (88%)
Pancreas (59) (60) (58) (58)
Atrophy 1 (2%) 3 (5%) 3 (5%) 5 (9%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05103-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:06:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.0312% 0.0625% 0.125%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Cyst 1 (2%) 2 (3%) 3 (5%) 5 (9%)
Focal Cellular Change 1 (2%) 4 (7%)
Hyperplasia, Lymphoid 2 (3%) 2 (3%)
Acinar Cell, Cytoplasmic Alteration 4 (7%) 3 (5%) 2 (3%) 2 (3%)
Salivary Glands (60) (60) (60) (60)
Hyperplasia, Lymphoid 4 (7%) 4 (7%) 6 (10%) 5 (8%)
Stomach, Forestomach (59) (60) (60) (59)
Diverticulum 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Ulcer 5 (8%) 2 (3%) 7 (12%) 6 (10%)
Mucosa, Hyperkeratosis 1 (2%)
Mucosa, Hyperplasia 10 (17%) 5 (8%) 16 (27%) 9 (15%)
Stomach, Glandular (59) (60) (58) (59)
Ectopic Tissue 1 (2%)
Edema 1 (2%) 1 (2%) 2 (3%)
Erosion 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Subacute 3 (5%) 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Ulcer 1 (2%)
Mucosa, Hyperplasia 1 (2%) 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Inflammation, Subacute 1 (100%)
Heart (60) (60) (60) (60)
Inflammation, Chronic 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Thrombosis 1 (2%) 1 (2%) 1 (2%)
Myocardium, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59) (60) (60) (59)
Accessory Adrenal Cortical Nodule 5 (8%) 6 (10%) 6 (10%) 6 (10%)
Angiectasis 1 (2%)
Cyst 2 (3%)
Degeneration, Fatty 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 3 (5%) 2 (3%) 2 (3%) 2 (3%)
Hyperplasia, Focal 1 (2%)
Hypertrophy, Focal 2 (3%) 1 (2%) 1 (2%) 1 (2%)
Capsule, Hyperplasia 1 (2%) 1 (2%)
Adrenal Medulla (59) (60) (60) (59)
Atrophy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05103-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:06:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.0312% 0.0625% 0.125%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Islets, Pancreatic (59) (60) (58) (59)
Hyperplasia 2 (3%) 2 (3%) 3 (5%)
Parathyroid Gland (52) (54) (58) (56)
Cyst 2 (4%) 4 (7%) 3 (5%)
Ectopic Tissue 1 (2%) 1 (2%)
Pituitary Gland (58) (58) (57) (56)
Pars Distalis, Angiectasis 3 (5%) 2 (3%) 5 (9%) 1 (2%)
Pars Distalis, Cyst 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 9 (16%) 4 (7%) 5 (9%) 8 (14%)
Thyroid Gland (59) (60) (60) (59)
Degeneration, Cystic 12 (20%) 7 (12%) 14 (23%) 14 (24%)
Ectopic Thymus 1 (2%)
Follicle, Cyst 3 (5%) 4 (7%) 2 (3%) 2 (3%)
Follicular Cell, Hyperplasia 13 (22%) 15 (25%) 9 (15%) 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (60) (58) (60) (60)
Ectasia 9 (15%) 9 (16%) 10 (17%) 11 (18%)
Inflammation, Chronic 2 (3%) 1 (2%) 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Pigmentation 2 (3%)
Ovary (59) (59) (60) (57)
Angiectasis 9 (15%) 5 (8%) 18 (30%) 12 (21%)
Cyst 11 (19%) 13 (22%) 11 (18%) 17 (30%)
Inflammation, Suppurative 8 (14%) 2 (3%) 4 (7%) 6 (11%)
Uterus (60) (60) (60) (60)
Angiectasis 2 (3%) 6 (10%) 16 (27%) 17 (28%)
Hydrometra 10 (17%) 6 (10%) 8 (13%) 5 (8%)
Hyperplasia, Cystic 53 (88%) 51 (85%) 52 (87%) 55 (92%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Inflammation, Suppurative 11 (18%) 3 (5%) 6 (10%) 3 (5%)
Metaplasia, Squamous 4 (7%) 3 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05103-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:06:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.0312% 0.0625% 0.125%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Hypercellularity 13 (22%) 15 (25%) 15 (25%) 26 (43%)
Myelofibrosis 7 (12%) 5 (8%) 6 (10%) 7 (12%)
Necrosis 1 (2%)
Lymph Node (9) (12) (6) (9)
Bronchial, Hyperplasia, Lymphoid 1 (11%)
Iliac, Hematopoietic Cell Proliferation 1 (11%) 1 (17%) 1 (11%)
Iliac, Hyperplasia, Lymphoid 6 (67%) 1 (8%) 3 (33%)
Inguinal, Hyperplasia, Lymphoid 1 (8%)
Mediastinal, Hyperplasia, Lymphoid 2 (22%) 1 (17%) 3 (33%)
Mediastinal, Inflammation, Suppurative 1 (11%)
Pancreatic, Hematopoietic Cell Proliferation 1 (11%)
Pancreatic, Hyperplasia, Lymphoid 1 (11%)
Pancreatic, Necrosis 1 (8%)
Renal, Hyperplasia, Lymphoid 6 (67%) 2 (17%) 5 (56%)
Lymph Node, Mandibular (56) (56) (59) (56)
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 2 (4%)
Hemorrhage 1 (2%) 2 (4%)
Hyperplasia, Lymphoid 5 (9%) 7 (13%) 8 (14%) 11 (20%)
Pigmentation 6 (11%) 5 (9%) 7 (13%)
Lymph Node, Mesenteric (57) (58) (55) (58)
Angiectasis 1 (2%) 1 (2%) 2 (4%)
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%) 1 (2%) 3 (5%)
Hemorrhage 4 (7%) 4 (7%) 1 (2%) 4 (7%)
Hyperplasia, Lymphoid 6 (11%) 4 (7%) 4 (7%) 9 (16%)
Pigmentation 1 (2%)
Spleen (59) (60) (59) (60)
Hematopoietic Cell Proliferation 20 (34%) 25 (42%) 26 (44%) 41 (68%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (3%) 1 (2%)
Pigmentation, Hemosiderin 3 (5%) 3 (5%) 2 (3%) 4 (7%)
Lymphoid Follicle, Atrophy 1 (2%)
Lymphoid Follicle, Hyperplasia 8 (14%) 3 (5%) 6 (10%) 5 (8%)
Red Pulp, Atrophy 1 (2%)
Thymus (54) (57) (55) (52)
Atrophy 2 (4%) 3 (5%) 4 (7%) 4 (8%)
Ectopic Parathyroid Gland 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05103-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:06:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.0312% 0.0625% 0.125%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (60) (59) (59)
Hyperplasia, Cystic 1 (2%) 3 (5%) 1 (2%) 2 (3%)
Hyperplasia, Lobular 1 (2%) 2 (3%) 1 (2%)
Skin (59) (60) (60) (60)
Acanthosis 1 (2%)
Edema 1 (2%) 1 (2%)
Inflammation, Subacute 1 (2%) 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Hyperostosis 2 (3%) 3 (5%) 3 (5%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 4 (7%) 2 (3%)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Chronic 2 (3%)
Necrosis 1 (2%)
Peripheral Nerve (1) (1) (1) (1)
Atrophy 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Congestion 1 (2%) 1 (2%)
Foreign Body 1 (2%) 1 (2%)
Hemorrhage 2 (3%) 2 (3%) 3 (5%) 3 (5%)
Hyperplasia, Lymphoid 3 (5%) 5 (8%) 7 (12%) 1 (2%)
Infiltration Cellular, Histiocyte 2 (3%) 5 (8%) 5 (8%) 5 (8%)
Inflammation, Subacute 1 (2%) 1 (2%) 3 (5%) 2 (3%)
Mineralization 1 (2%)
Thrombosis 1 (2%) 3 (5%) 2 (3%) 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (3%) 3 (5%) 8 (13%) 15 (25%)
Nose (60) (60) (60) (60)
Exudate 3 (5%) 2 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05103-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:06:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.0312% 0.0625% 0.125%
CONTROL
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (3) (7)
Cataract 2 (100%) 1 (33%) 2 (29%)
Inflammation, Chronic 1 (50%) 5 (71%)
Phthisis Bulbi 2 (67%) 1 (14%)
Harderian Gland (22) (32) (31) (40)
Hyperplasia 1 (5%) 1 (3%) 3 (10%) 1 (3%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (60) (60) (59)
Casts Protein 19 (32%) 22 (37%) 16 (27%) 8 (14%)
Cyst 2 (3%) 2 (3%) 1 (2%)
Glomerulosclerosis 1 (2%) 1 (2%)
Hydronephrosis 1 (2%)
Hyperplasia, Lymphoid 9 (15%) 11 (18%) 7 (12%) 4 (7%)
Metaplasia, Osseous 1 (2%) 1 (2%) 2 (3%) 1 (2%)
Mineralization 1 (2%) 2 (3%) 1 (2%)
Renal Tubule, Atrophy 1 (2%)
Renal Tubule, Cytoplasmic Alteration 1 (2%) 1 (2%) 2 (3%)
Renal Tubule, Dilatation 3 (5%) 1 (2%) 2 (3%) 2 (3%)
Renal Tubule, Necrosis 2 (3%) 1 (2%)
Renal Tubule, Pigmentation 1 (2%) 1 (2%) 1 (2%)
Renal Tubule, Regeneration 7 (12%) 11 (18%) 11 (18%) 7 (12%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (59) (60) (59) (60)
Edema 1 (2%) 2 (3%) 1 (2%)
Hyperplasia, Lymphoid 2 (3%) 3 (5%) 3 (5%) 3 (5%)
Inflammation, Subacute 2 (3%) 1 (2%)
Mucosa, Hyperplasia 1 (2%) 2 (3%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05103-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:06:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.0312% 0.0625% 0.125%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 9 10 10
Early Deaths
Natural Death 5 3 4 5
Moribund Sacrifice 3 12 11 13
Accidently Killed 1
Survivors
Terminal Sacrifice 42 36 35 30
Missing 1
Animals Examined Microscopically 60 60 60 59
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (58) (59) (59) (55)
Edema 1 (2%)
Intestine Large, Rectum (58) (59) (58) (58)
Edema 1 (2%)
Inflammation, Chronic 1 (2%)
Intestine Large, Cecum (59) (58) (58) (58)
Edema 3 (5%) 4 (7%) 1 (2%) 8 (14%)
Parasite Metazoan 1 (2%)
Intestine Small, Jejunum (59) (58) (59) (58)
Peyer's Patch, Hyperplasia 1 (2%)
Intestine Small, Ileum (58) (57) (57) (58)
Amyloid Deposition 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Peyer's Patch, Hyperplasia 2 (3%)
Liver (59) (60) (59) (59)
Basophilic Focus 3 (5%) 3 (5%) 4 (7%) 3 (5%)
Clear Cell Focus 6 (10%) 7 (12%) 3 (5%) 3 (5%)
Congestion 1 (2%)
Cyst 1 (2%)
Developmental Malformation 1 (2%)
Eosinophilic Focus 4 (7%) 4 (7%) 7 (12%) 3 (5%)
Hematopoietic Cell Proliferation 1 (2%) 2 (3%) 4 (7%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Subacute 3 (5%) 2 (3%) 6 (10%) 3 (5%)
Mineralization 2 (3%) 2 (3%)
Mixed Cell Focus 5 (8%) 2 (3%) 1 (2%) 2 (3%)
Necrosis 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Hepatocyte, Nuclear Alteration 1 (2%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05103-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:06:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.0312% 0.0625% 0.125%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Vacuolization Cytoplasmic 1 (2%)
Kupffer Cell, Hyperplasia 1 (2%) 2 (3%) 2 (3%) 5 (8%)
Kupffer Cell, Pigmentation 1 (2%) 2 (3%) 2 (3%)
Lobules, Necrosis 1 (2%) 4 (7%) 4 (7%) 3 (5%)
Mesentery (3) (2) (1) (4)
Fat, Necrosis 3 (100%) 1 (100%) 2 (50%)
Pancreas (59) (60) (59) (59)
Atrophy 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Cyst 1 (2%)
Acinar Cell, Cytoplasmic Alteration 1 (2%) 1 (2%) 2 (3%) 1 (2%)
Salivary Glands (59) (60) (59) (59)
Hyperplasia, Lymphoid 2 (3%) 1 (2%) 3 (5%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Stomach, Forestomach (59) (60) (60) (58)
Diverticulum 1 (2%)
Ulcer 2 (3%) 1 (2%) 3 (5%)
Mucosa, Hyperplasia 4 (7%) 1 (2%) 4 (7%) 4 (7%)
Stomach, Glandular (59) (60) (59) (58)
Ectopic Tissue 1 (2%)
Edema 1 (2%) 1 (2%)
Erosion 1 (2%) 1 (2%)
Mineralization 1 (2%)
Mucosa, Hyperplasia 2 (3%) 2 (3%)
Tooth (13) (2) (4) (3)
Dysplasia 13 (100%) 2 (100%) 4 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (59)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%) 3 (5%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (58) (60) (60) (59)
Accessory Adrenal Cortical Nodule 3 (5%) 4 (7%) 3 (5%) 2 (3%)
Cyst 1 (2%)
Hyperplasia, Focal 4 (7%) 4 (7%) 7 (12%) 3 (5%)
Hypertrophy, Focal 14 (24%) 20 (33%) 17 (28%) 10 (17%)
Vacuolization Cytoplasmic 1 (2%)
Capsule, Hyperplasia 5 (9%) 4 (7%) 5 (8%) 5 (8%)
Adrenal Medulla (59) (59) (60) (59)
Hyperplasia 1 (2%) 2 (3%)
Islets, Pancreatic (59) (59) (59) (59)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05103-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:06:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.0312% 0.0625% 0.125%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hemorrhage 1 (2%)
Hyperplasia 17 (29%) 16 (27%) 12 (20%) 8 (14%)
Parathyroid Gland (57) (56) (56) (58)
Cyst 2 (4%) 2 (4%) 6 (11%) 1 (2%)
Pituitary Gland (57) (54) (59) (54)
Pars Distalis, Cyst 2 (4%) 3 (6%) 2 (3%) 3 (6%)
Pars Distalis, Hyperplasia, Focal 1 (2%)
Thyroid Gland (59) (60) (59) (59)
Degeneration, Cystic 10 (17%) 9 (15%) 12 (20%) 6 (10%)
Follicle, Cyst 2 (3%) 3 (5%) 1 (2%)
Follicular Cell, Hyperplasia 6 (10%) 6 (10%) 4 (7%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Cyst 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (2) (2)
Dilatation 2 (100%) 2 (100%)
Epididymis (59) (60) (60) (59)
Atypia Cellular 1 (2%)
Granuloma Sperm 1 (2%)
Hypospermia 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Spermatocele 1 (2%) 2 (3%) 2 (3%)
Preputial Gland (58) (58) (59) (58)
Angiectasis 1 (2%) 1 (2%)
Atrophy 2 (3%) 1 (2%)
Ectasia 28 (48%) 23 (40%) 30 (51%) 28 (48%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic 25 (43%) 19 (33%) 22 (37%) 14 (24%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 8 (14%) 13 (22%) 15 (25%) 11 (19%)
Prostate (59) (60) (60) (57)
Hemorrhage 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Seminal Vesicle (59) (60) (60) (59)
Dilatation 15 (25%) 10 (17%) 11 (18%) 8 (14%)
Fibrosis 1 (2%)
Hemorrhage 2 (3%) 1 (2%)
Inflammation, Chronic 2 (3%) 1 (2%)
Testes (59) (60) (60) (59)
Granuloma Sperm 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05103-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:06:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.0312% 0.0625% 0.125%
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Interstitial Cell, Hyperplasia 1 (2%)
Seminiferous Tubule, Atrophy 3 (5%) 1 (2%) 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (60) (60) (59)
Hypercellularity 5 (8%) 12 (20%) 11 (18%) 13 (22%)
Necrosis 1 (2%) 1 (2%)
Lymph Node (3) (3) (5) (7)
Bronchial, Hyperplasia, Lymphoid 1 (14%)
Iliac, Hyperplasia, Lymphoid 1 (33%)
Inguinal, Hematopoietic Cell Proliferation 1 (14%)
Inguinal, Hyperplasia, Lymphoid 2 (67%) 2 (67%) 1 (20%) 3 (43%)
Inguinal, Pigmentation 1 (33%)
Mediastinal, Hematopoietic Cell Proliferation 1 (14%)
Mediastinal, Hyperplasia, Lymphoid 1 (14%)
Renal, Hemorrhage 1 (33%)
Renal, Hyperplasia, Lymphoid 1 (33%)
Lymph Node, Mandibular (56) (58) (59) (55)
Atrophy 2 (3%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%) 3 (5%) 1 (2%) 5 (9%)
Pigmentation 6 (11%) 3 (5%) 6 (10%) 3 (5%)
Lymph Node, Mesenteric (58) (58) (59) (58)
Angiectasis 2 (3%) 2 (3%)
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 4 (7%) 3 (5%) 5 (9%)
Hemorrhage 19 (33%) 15 (26%) 18 (31%) 22 (38%)
Hyperplasia, Lymphoid 4 (7%) 12 (21%) 8 (14%) 4 (7%)
Pigmentation 1 (2%) 1 (2%) 1 (2%)
Spleen (59) (60) (59) (59)
Hematopoietic Cell Proliferation 10 (17%) 22 (37%) 16 (27%) 19 (32%)
Infiltration Cellular, Mast Cell 1 (2%)
Lymphoid Follicle, Atrophy 1 (2%) 4 (7%) 1 (2%)
Lymphoid Follicle, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Red Pulp, Atrophy 2 (3%) 1 (2%)
Thymus (53) (57) (50) (52)
Atrophy 4 (7%) 4 (8%)
Congestion 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05103-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:06:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.0312% 0.0625% 0.125%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (60) (60) (59)
Acanthosis 1 (2%) 2 (3%)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Subacute 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (59)
Hyperostosis 2 (3%) 3 (5%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (59)
Compression 1 (2%)
Cyst 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (59)
Congestion 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 3 (5%) 3 (5%)
Hyperplasia, Lymphoid 3 (5%) 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 6 (10%) 8 (13%) 5 (8%) 10 (17%)
Inflammation, Subacute 1 (2%)
Thrombosis 1 (2%) 1 (2%) 2 (3%)
Alveolar Epithelium, Hyperplasia 7 (12%) 7 (12%) 6 (10%) 11 (19%)
Nose (59) (60) (60) (59)
Exudate 1 (2%) 1 (2%) 1 (2%) 3 (5%)
Foreign Body 1 (2%)
Mucosa, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (4) (9)
Cataract 1 (50%) 1 (25%) 2 (22%)
Inflammation, Chronic 1 (50%) 3 (75%) 2 (22%)
Phthisis Bulbi 1 (50%)
Cornea, Hyperplasia 1 (25%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05103-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:06:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.0312% 0.0625% 0.125%
CONTROL
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Harderian Gland (26) (31) (33) (36)
Hyperplasia 1 (3%) 2 (6%) 3 (8%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (60) (60) (59)
Casts Protein 7 (12%) 14 (23%) 10 (17%) 5 (8%)
Cyst 13 (22%) 13 (22%) 10 (17%) 12 (20%)
Hydronephrosis 1 (2%) 4 (7%) 2 (3%) 1 (2%)
Hyperplasia, Lymphoid 3 (5%) 4 (7%) 5 (8%) 2 (3%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%) 2 (3%)
Mineralization 41 (69%) 35 (58%) 41 (68%) 33 (56%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Atrophy 1 (2%) 1 (2%) 2 (3%)
Renal Tubule, Casts Protein 1 (2%)
Renal Tubule, Dilatation 2 (3%) 1 (2%) 3 (5%) 1 (2%)
Renal Tubule, Hyperplasia 2 (3%)
Renal Tubule, Necrosis 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 1 (2%)
Renal Tubule, Regeneration 50 (85%) 47 (78%) 53 (88%) 44 (75%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urethra (1)
Concretion 1 (100%)
Inflammation, Subacute 1 (100%)
Urinary Bladder (59) (60) (59) (59)
Dilatation 2 (3%)
Edema 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Suppurative 1 (2%)
Mucosa, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
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