TDMS Study 05103-04 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL
NTP Experiment-Test: 05103-04 Report: PEIRPT09
Study Type: CHRONIC Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
CORE STUDY
Facility: Southern Research Institute
Chemical CAS #: 3296-90-0
Lock Date: 02/12/92
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25023 Missing
25009 Missing 25019 Moribund Sacrifice
25020 Natural Death 25006 Terminal Sacrifice
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 002 UNTREATD CONTROL
Include 004 0.0312%
Include 006 0.0625%
Include 008 0.125%
Include 001 UNTREATD CONTROL
Include 003 0.0312%
Include 005 0.0625%
Include 007 0.125%
Page 1
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 5|
DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 0| 4| 8| 4| 4| 4| 4| 4| 4| 7|
| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 1| 5| 3| 4| 3| 3| 8| 3| 3| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + I + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Degeneration, Fatty | 1 |
Developmental Malformation | X |
Eosinophilic Focus | X 3 2 |
Hematopoietic Cell Proliferation | 2 4 4 2 4 3 4|
Hyperplasia, Lymphoid | 2 2 2 |
Inflammation, Subacute | 1 2 1 |
Mixed Cell Focus | |
Kupffer Cell, Hyperplasia | 4 4 3 4 4|
Kupffer Cell, Pigmentation | 1 2 |
Lobules, Necrosis | 1 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | X |
Acinar Cell, Cytoplasmic Alteration | 4 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Mucosa, Hyperplasia | 1 3 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Edema | 2 |
Erosion | 2 |
Hyperplasia, Lymphoid | |
Inflammation, Subacute | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 5|
DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 0| 4| 8| 4| 4| 4| 4| 4| 4| 7|
| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 1| 5| 3| 4| 3| 3| 8| 3| 3| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Subacute | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Hematopoietic Cell Proliferation | 2 2 |
Hypertrophy, Focal | 2 |
Capsule, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + M +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 3 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 1 2 2 1 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 2 1 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + M + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 3 |
Cyst | X X X X X |
Inflammation, Suppurative | 4 4 4 4 4 4|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 2 3 4 3 4 |
Hyperplasia, Cystic | 2 3 3 3 2 3 3 3 3 3 2 3 3 2 1 3 1 3 2 3 3 2 1|
Inflammation, Suppurative | 2 2 2 3 2 1 2|
Metaplasia, Squamous | 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 5|
DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 0| 4| 8| 4| 4| 4| 4| 4| 4| 7|
| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 1| 5| 3| 4| 3| 3| 8| 3| 3| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 3 2 4 3 2 4 2 2|
Myelofibrosis | 2 3 2 2 |
Necrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + +|
Bronchial, Hyperplasia, Lymphoid | 4 |
Iliac, Hematopoietic Cell | |
Proliferation | 3 |
Iliac, Hyperplasia, Lymphoid | 3 4 3 3 3|
Mediastinal, Hyperplasia, Lymphoid | 4 |
Renal, Hyperplasia, Lymphoid | 3 4 4 4 4|
__________________________________________________________________________|
Lymph Node, Bronchial | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + M + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 3 3 3|
Pigmentation | 2 3 2 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Atrophy | |
Hematopoietic Cell Proliferation | 2 3 |
Hemorrhage | 2 1 1 |
Hyperplasia, Lymphoid | 2 3 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 3 4 4 2 4 4 4 2 3 4|
Hyperplasia, Lymphoid | 3 |
Pigmentation, Hemosiderin | 2 3 |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 2 2 2 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + M + + + M|
Atrophy | 3 |
Ectopic Parathyroid Gland | X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 |
Hyperplasia, Lobular | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 5|
DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 0| 4| 8| 4| 4| 4| 4| 4| 4| 7|
| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 1| 5| 3| 4| 3| 3| 8| 3| 3| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | + |
Atrophy | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1|
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Subacute | 2 |
Thrombosis | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + |
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 1 1 1 1 1 1|
Cyst | |
Glomerulosclerosis | |
Hyperplasia, Lymphoid | 2 2 2 2 |
Metaplasia, Osseous | |
Mineralization | |
Renal Tubule, Atrophy | 2 |
Renal Tubule, Cytoplasmic Alteration | 2 |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 1 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3|
Hyperplasia, Lymphoid | 2 2 |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 2|
| 0| 6| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + A|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Degeneration, Fatty | |
Developmental Malformation | |
Eosinophilic Focus | 1 |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | |
Inflammation, Subacute | 2 1 |
Mixed Cell Focus | 4 |
Kupffer Cell, Hyperplasia | 2 |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 1 4|
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
Acinar Cell, Cytoplasmic Alteration | 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 2 2 |
Mucosa, Hyperplasia | 1 3 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Edema | |
Erosion | |
Hyperplasia, Lymphoid | 3 |
Inflammation, Subacute | 2 2 |
Mucosa, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 2|
| 0| 6| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X 2 |
Hematopoietic Cell Proliferation | 3 |
Hypertrophy, Focal | 2 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + M + + + + + + + M + + + + + + + + M|
Cyst | X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 3 2 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 1 1 2 |
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | 1 1 1 3 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 4 2 |
Cyst | X X X X X |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 |
Hydrometra | 3 3 3 3 3 |
Hyperplasia, Cystic | 3 3 3 3 4 3 2 2 2 3 3 3 2 4 3 2 2 3 4 3 2 2|
Inflammation, Suppurative | 2 1 |
Metaplasia, Squamous | 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 2|
| 0| 6| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 4 2 2 |
Myelofibrosis | 3 2 1 |
Necrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + |
Bronchial, Hyperplasia, Lymphoid | |
Iliac, Hematopoietic Cell | |
Proliferation | |
Iliac, Hyperplasia, Lymphoid | 4 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + I + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 4 2 |
Pigmentation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M M + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 3 2 2 3 4 |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 |
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia | 3 2 3 2 3 |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + M + + + +|
Atrophy | 3 |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
Hyperplasia, Lobular | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 2|
| 0| 6| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Hyperostosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Peripheral Nerve | |
Atrophy | |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Histiocyte | |
Inflammation, Subacute | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 3 1 1 1 1 1 1 |
Cyst | X |
Glomerulosclerosis | 3 |
Hyperplasia, Lymphoid | 2 2 2 2 2 |
Metaplasia, Osseous | 2 |
Mineralization | 4 |
Renal Tubule, Atrophy | |
Renal Tubule, Cytoplasmic Alteration | |
Renal Tubule, Dilatation | 3 2 |
Renal Tubule, Pigmentation | 3 |
Renal Tubule, Regeneration | 4 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | |
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 2| 4| | |
DAY ON TEST | 8| 0| | |
| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| | T |
ANIMAL ID | 2| 2| | A |
UNTREATD | 9| 9| | L |
CONTROL | 4| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + A | 51 |
__________________________________________________________________________|____________|
Gallbladder | + A | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 52 |
Edema | | 3 2.3|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A | 51 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A | 49 |
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A | 51 |
__________________________________________________________________________|____________|
Liver | + A | 51 |
Basophilic Focus | | 1 2.0|
Degeneration, Fatty | | 1 1.0|
Developmental Malformation | | 1 |
Eosinophilic Focus | | 4 2.0|
Hematopoietic Cell Proliferation | 3 | 9 3.3|
Hyperplasia, Lymphoid | | 3 2.0|
Inflammation, Subacute | | 5 1.4|
Mixed Cell Focus | | 1 4.0|
Kupffer Cell, Hyperplasia | | 6 3.5|
Kupffer Cell, Pigmentation | | 2 1.5|
Lobules, Necrosis | | 4 2.3|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Necrosis | | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | + A | 51 |
Atrophy | | 1 4.0|
Cyst | | 1 |
Acinar Cell, Cytoplasmic Alteration | | 4 3.5|
__________________________________________________________________________|____________|
Salivary Glands | + + | 52 |
Hyperplasia, Lymphoid | | 4 2.3|
__________________________________________________________________________|____________|
Stomach, Forestomach | + A | 51 |
Ulcer | 2 | 5 2.0|
Mucosa, Hyperplasia | 3 | 9 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + A | 51 |
Ectopic Tissue | | 1 |
Edema | | 1 2.0|
Erosion | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 2| 4| | |
DAY ON TEST | 8| 0| | |
| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| | T |
ANIMAL ID | 2| 2| | A |
UNTREATD | 9| 9| | L |
CONTROL | 4| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Subacute | 3 | 3 2.3|
Mucosa, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + | 52 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + A | 51 |
Accessory Adrenal Cortical Nodule | | 5 2.0|
Hematopoietic Cell Proliferation | | 3 2.3|
Hypertrophy, Focal | | 2 2.0|
Capsule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + A | 51 |
Atrophy | | 1 4.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + A | 51 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M A | 44 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + A | 50 |
Pars Distalis, Angiectasis | | 3 2.7|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | | 8 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + A | 51 |
Degeneration, Cystic | | 12 1.5|
Follicle, Cyst | | 3 |
Follicular Cell, Hyperplasia | | 13 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + | 52 |
Ectasia | 3 3 | 2 3.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + | 51 |
Angiectasis | | 9 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 2| 4| | |
DAY ON TEST | 8| 0| | |
| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| | T |
ANIMAL ID | 2| 2| | A |
UNTREATD | 9| 9| | L |
CONTROL | 4| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | | 10 |
Inflammation, Suppurative | 4 | 8 4.0|
__________________________________________________________________________|____________|
Uterus | + + | 52 |
Angiectasis | | 2 3.0|
Hydrometra | | 10 3.1|
Hyperplasia, Cystic | 1 | 46 2.6|
Inflammation, Suppurative | | 9 1.9|
Metaplasia, Squamous | | 4 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 52 |
Hypercellularity | 3 | 13 2.7|
Myelofibrosis | | 7 2.1|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 9 |
Bronchial, Hyperplasia, Lymphoid | | 1 4.0|
Iliac, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Iliac, Hyperplasia, Lymphoid | | 6 3.3|
Mediastinal, Hyperplasia, Lymphoid | | 2 3.5|
Renal, Hyperplasia, Lymphoid | | 6 3.8|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + A | 48 |
Atrophy | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | | 5 3.0|
Pigmentation | | 6 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + A | 49 |
Angiectasis | | 1 3.0|
Atrophy | | 1 3.0|
Hematopoietic Cell Proliferation | | 2 2.5|
Hemorrhage | | 4 1.3|
Hyperplasia, Lymphoid | | 5 2.4|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 2 |
__________________________________________________________________________|____________|
Spleen | + A | 51 |
Hematopoietic Cell Proliferation | 4 | 20 3.3|
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation, Hemosiderin | | 3 2.3|
Lymphoid Follicle, Atrophy | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 2| 4| | |
DAY ON TEST | 8| 0| | |
| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| | T |
ANIMAL ID | 2| 2| | A |
UNTREATD | 9| 9| | L |
CONTROL | 4| 8| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoid Follicle, Hyperplasia | | 8 2.4|
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + A | 46 |
Atrophy | | 2 3.0|
Ectopic Parathyroid Gland | | 1 |
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 52 |
Hyperplasia, Cystic | | 1 3.0|
Hyperplasia, Lobular | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + | 52 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 52 |
Hyperostosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 52 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 52 |
Hemorrhage | | 2 1.5|
Hyperplasia, Lymphoid | | 3 2.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Inflammation, Subacute | | 1 2.0|
Thrombosis | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + | 52 |
Exudate | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + A | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 18 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 2| 4| | |
DAY ON TEST | 8| 0| | |
| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| | T |
ANIMAL ID | 2| 2| | A |
UNTREATD | 9| 9| | L |
CONTROL | 4| 8| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + A | 51 |
Casts Protein | | 17 1.1|
Cyst | | 1 |
Glomerulosclerosis | | 1 3.0|
Hyperplasia, Lymphoid | | 9 2.0|
Metaplasia, Osseous | | 1 2.0|
Mineralization | | 1 4.0|
Renal Tubule, Atrophy | | 1 2.0|
Renal Tubule, Cytoplasmic Alteration | | 1 2.0|
Renal Tubule, Dilatation | | 3 2.0|
Renal Tubule, Pigmentation | | 1 3.0|
Renal Tubule, Regeneration | | 7 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + A | 51 |
Edema | | 1 3.0|
Hyperplasia, Lymphoid | | 2 2.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 6| 6| 3| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 4| 6| 9| 8| 4| 4| 4| 3| 4| 7| 0| 4| 6| 4| 4| 5| 1| 4| 4| 3| 7| 4| 4| 7| 4|
| 3| 8| 2| 6| 3| 3| 3| 5| 3| 7| 6| 3| 9| 3| 3| 5| 3| 3| 3| 0| 9| 3| 3| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0312% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 |
Clear Cell Focus | |
Eosinophilic Focus | 3 |
Hematopoietic Cell Proliferation | 2 3 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Subacute | 1 |
Mixed Cell Focus | 3 |
Centrilobular, Necrosis | 3 |
Kupffer Cell, Hyperplasia | 3 |
Lobules, Necrosis | 1 3 1 4 |
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Necrosis | 3 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 |
Cyst | X |
Hyperplasia, Lymphoid | 2 |
Acinar Cell, Cytoplasmic Alteration | 3 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Ulcer | 2 |
Mucosa, Hyperplasia | 2 2 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Subacute | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 6| 6| 3| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 4| 6| 9| 8| 4| 4| 4| 3| 4| 7| 0| 4| 6| 4| 4| 5| 1| 4| 4| 3| 7| 4| 4| 7| 4|
| 3| 8| 2| 6| 3| 3| 3| 5| 3| 7| 6| 3| 9| 3| 3| 5| 3| 3| 3| 0| 9| 3| 3| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0312% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X|
Angiectasis | |
Cyst | |
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | |
Hypertrophy, Focal | |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 1 2 2 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 1 3 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Cyst | X X X X |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 2 |
Hydrometra | 2 4 |
Hyperplasia, Cystic | 2 2 1 3 3 2 4 2 3 3 2 3 2 2 2 3 2 2 3 3 |
Inflammation, Suppurative | 2 |
Metaplasia, Squamous | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 3 3 2 3 3 |
Myelofibrosis | 3 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 6| 6| 3| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 4| 6| 9| 8| 4| 4| 4| 3| 4| 7| 0| 4| 6| 4| 4| 5| 1| 4| 4| 3| 7| 4| 4| 7| 4|
| 3| 8| 2| 6| 3| 3| 3| 5| 3| 7| 6| 3| 9| 3| 3| 5| 3| 3| 3| 0| 9| 3| 3| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0312% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | |
Pancreatic, Necrosis | 4 |
Renal, Hyperplasia, Lymphoid | 3 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + M + + + + + M + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 3 3 |
Pigmentation | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + I + + + + + + +|
Angiectasis | 3 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 1 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 2 2 3 1 3 3 3 1 4 4 2 |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 2 |
Lymphoid Follicle, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 |
Hyperplasia, Lobular | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Subacute | 3 |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 6| 6| 3| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 4| 6| 9| 8| 4| 4| 4| 3| 4| 7| 0| 4| 6| 4| 4| 5| 1| 4| 4| 3| 7| 4| 4| 7| 4|
| 3| 8| 2| 6| 3| 3| 3| 5| 3| 7| 6| 3| 9| 3| 3| 5| 3| 3| 3| 0| 9| 3| 3| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0312% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 3 2 2 |
Infiltration Cellular, Histiocyte | 2 2 |
Inflammation, Subacute | |
Thrombosis | X X |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 2 1 1 2 1 1 1 1 1 |
Glomerulosclerosis | |
Hyperplasia, Lymphoid | 2 2 2 2 |
Metaplasia, Osseous | 2 |
Renal Tubule, Cytoplasmic Alteration | 3 |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Regeneration | 1 3 3 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 4| 2| 4| 0| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| |
| 7| 3| 3| 3| 3| 1| 9| 3| 3| 5| 6| 3| 7| 3| 8| 3| 3| 4| 4| 4| 4| 4| 6| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.0312% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + M + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 3 2 | 3 2.0|
Clear Cell Focus | 1 | 1 1.0|
Eosinophilic Focus | | 1 3.0|
Hematopoietic Cell Proliferation | 4 3 2 4 | 6 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Subacute | 1 | 2 1.0|
Mixed Cell Focus | 2 | 2 2.5|
Centrilobular, Necrosis | | 1 3.0|
Kupffer Cell, Hyperplasia | 3 2 3 | 4 2.8|
Lobules, Necrosis | 1 3 3 | 7 2.3|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Fat, Necrosis | 4 4 | 5 3.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 3 3.7|
Cyst | X | 2 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
Acinar Cell, Cytoplasmic Alteration | 3 | 3 3.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | | 1 2.0|
Ulcer | 2 | 2 2.0|
Mucosa, Hyperplasia | 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 2.0|
Inflammation, Subacute | 2 | 1 2.0|
Mucosa, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 4| 2| 4| 0| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| |
| 7| 3| 3| 3| 3| 1| 9| 3| 3| 5| 6| 3| 7| 3| 8| 3| 3| 4| 4| 4| 4| 4| 6| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.0312% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X| 6 |
Angiectasis | 3 | 1 3.0|
Cyst | X X | 2 |
Degeneration, Fatty | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 3 | 2 2.5|
Hypertrophy, Focal | 2 | 1 2.0|
Capsule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + + + + + M + + + + + + + + + + + + M| 45 |
Cyst | X X | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
Pars Distalis, Angiectasis | 2 3| 2 2.5|
Pars Distalis, Hyperplasia, Focal | 3 3| 4 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 | 6 1.8|
Follicle, Cyst | X X X | 3 |
Follicular Cell, Hyperplasia | 4 3 4 1 2 1 2 1 2 | 15 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 3 2 | 5 2.2|
Cyst | X X X X X X X X| 12 |
Inflammation, Suppurative | 4 | 2 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 4| 2| 4| 0| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| |
| 7| 3| 3| 3| 3| 1| 9| 3| 3| 5| 6| 3| 7| 3| 8| 3| 3| 4| 4| 4| 4| 4| 6| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.0312% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Angiectasis | 2 2 4 3 | 6 2.8|
Hydrometra | 3 4 3 | 5 3.2|
Hyperplasia, Cystic | 3 3 3 2 2 3 2 2 3 3 3 3 4 3 1 2 2 3 2 2 2| 41 2.5|
Inflammation, Suppurative | 2 | 2 2.0|
Metaplasia, Squamous | 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 4 3 2 3 2 3 2 3 2 | 15 2.7|
Myelofibrosis | 2 | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 12 |
Iliac, Hyperplasia, Lymphoid | 2 | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Pancreatic, Necrosis | | 1 4.0|
Renal, Hyperplasia, Lymphoid | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| 46 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 2 3 | 6 2.5|
Pigmentation | 2 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + I + + + + + + + + + + + +| 48 |
Angiectasis | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 1 | 4 1.5|
Hyperplasia, Lymphoid | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 4 2 4 3 2 3 3 2 2 2 | 25 2.6|
Hyperplasia, Lymphoid | 2 3 | 2 2.5|
Pigmentation, Hemosiderin | 2 | 3 2.0|
Lymphoid Follicle, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + M + + + + + + + + + + + + +| 47 |
Atrophy | 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 2 | 3 1.7|
Hyperplasia, Lobular | 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 4| 2| 4| 0| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| |
| 7| 3| 3| 3| 3| 1| 9| 3| 3| 5| 6| 3| 7| 3| 8| 3| 3| 4| 4| 4| 4| 4| 6| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.0312% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Subacute | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X | 4 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Foreign Body | 2 | 1 2.0|
Hemorrhage | 3 | 2 2.5|
Hyperplasia, Lymphoid | 2 | 5 2.2|
Infiltration Cellular, Histiocyte | 4 1 1 | 5 2.0|
Inflammation, Subacute | 3 | 1 3.0|
Thrombosis | X | 3 |
Alveolar Epithelium, Hyperplasia | 1 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | 3 | 2 2.5|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + | 27 |
Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts Protein | 2 1 1 1 1 2 1 1 | 17 1.2|
Glomerulosclerosis | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 2 3 2 2 | 9 2.2|
Metaplasia, Osseous | | 1 2.0|
Renal Tubule, Cytoplasmic Alteration | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 4| 2| 4| 0| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| |
| 7| 3| 3| 3| 3| 1| 9| 3| 3| 5| 6| 3| 7| 3| 8| 3| 3| 4| 4| 4| 4| 4| 6| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.0312% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Dilatation | | 1 1.0|
Renal Tubule, Regeneration | 1 1 3 | 10 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3|
DAY ON TEST | 6| 1| 4| 9| 3| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| 2| 4| 7| 1| 4| 0| 4| 4| 4| 9|
| 9| 9| 4| 3| 9| 4| 5| 4| 0| 4| 4| 4| 3| 4| 4| 6| 4| 5| 1| 4| 9| 4| 4| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0625% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + A + + + + A + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Edema | 2 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + A + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + A + + + + + + +|
Basophilic Focus | 1 4 |
Cyst | |
Degeneration, Fatty | |
Eosinophilic Focus | 2 |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | |
Inflammation, Subacute | 2 3 |
Mixed Cell Focus | 3 |
Centrilobular, Necrosis | 2 |
Kupffer Cell, Hyperplasia | 2 3 4 3 |
Kupffer Cell, Pigmentation | 1 |
Lobules, Necrosis | 3 2 3 |
__________________________________________________________________________|
Mesentery | + + + +|
Inflammation, Chronic | |
Fat, Necrosis | 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 |
Cyst | X X X |
Acinar Cell, Cytoplasmic Alteration | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Inflammation, Suppurative | 2 |
Ulcer | 1 |
Mucosa, Hyperplasia | 1 2 1 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + A + + + + + + +|
Edema | |
Erosion | 3 |
Inflammation, Subacute | 1 |
Mineralization | 3 |
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3|
DAY ON TEST | 6| 1| 4| 9| 3| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| 2| 4| 7| 1| 4| 0| 4| 4| 4| 9|
| 9| 9| 4| 3| 9| 4| 5| 4| 0| 4| 4| 4| 3| 4| 4| 6| 4| 5| 1| 4| 9| 4| 4| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0625% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Mineralization | 4 |
Thrombosis | X |
Myocardium, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X 2 X|
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | 2 |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 1 2 2 2 1 |
Ectopic Thymus | X |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 1 1 3 1 3 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 2 4 3 2 2 3 2 |
Cyst | X X X X X |
Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 3 3 4 3 4 |
Hydrometra | 3 3 3 |
Hyperplasia, Cystic | 2 3 2 2 2 3 3 2 3 3 2 3 2 2 3 2 2 3 3 2 3 2 |
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3|
DAY ON TEST | 6| 1| 4| 9| 3| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| 2| 4| 7| 1| 4| 0| 4| 4| 4| 9|
| 9| 9| 4| 3| 9| 4| 5| 4| 0| 4| 4| 4| 3| 4| 4| 6| 4| 5| 1| 4| 9| 4| 4| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0625% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 4 3 3 2 3 3 3 3 2 3 |
Myelofibrosis | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Hematopoietic Cell | |
Proliferation | 2 |
Mediastinal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 1 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + A + + + + + + +|
Angiectasis | 3 |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 4 2 2 4 2 4 4 2 3 |
Hyperplasia, Lymphoid | 2 |
Pigmentation, Hemosiderin | |
Lymphoid Follicle, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | M I + + + + + + M + + + + + + M + + M + + + + + +|
Atrophy | 3 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1|
Hyperplasia, Lobular | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Subacute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3|
DAY ON TEST | 6| 1| 4| 9| 3| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| 2| 4| 7| 1| 4| 0| 4| 4| 4| 9|
| 9| 9| 4| 3| 9| 4| 5| 4| 0| 4| 4| 4| 3| 4| 4| 6| 4| 5| 1| 4| 9| 4| 4| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0625% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Inflammation, Chronic | 2 2 |
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | M |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 3 |
Hyperplasia, Lymphoid | 2 2 2 2 |
Infiltration Cellular, Histiocyte | 2 2 1 |
Inflammation, Subacute | 3 |
Mineralization | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 1 2 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | |
Phthisis Bulbi | 3 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + +|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 1 1 1 |
Cyst | X |
Hyperplasia, Lymphoid | 2 4 |
Metaplasia, Osseous | 2 |
Mineralization | 1 4 |
Renal Tubule, Cytoplasmic Alteration | 2 3 |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 2 |
Renal Tubule, Regeneration | 4 1 1 3 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +|
Edema | 3 |
Hyperplasia, Lymphoid | 2 2 |
Inflammation, Subacute | 2 2 |
Mucosa, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 6| 1| 4| 4| 4| 4| 2| 8| 5| 6| 3| 0| 4| 7| 4| 3| 5| 4| 4| 4| 4| 4| 3| 4|
| 4| 9| 8| 4| 4| 4| 4| 9| 3| 7| 9| 9| 7| 4| 9| 4| 3| 2| 4| 4| 4| 4| 4| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.0625% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + I + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + I + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cyst | X |
Degeneration, Fatty | 1 |
Eosinophilic Focus | 2 3 |
Hematopoietic Cell Proliferation | 3 2 2 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Subacute | |
Mixed Cell Focus | 3 2 |
Centrilobular, Necrosis | 3 |
Kupffer Cell, Hyperplasia | 4 3 2 |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 1 1 2|
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | 4 |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + +|
Atrophy | |
Cyst | |
Acinar Cell, Cytoplasmic Alteration | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Suppurative | |
Ulcer | 2 2 2 2 |
Mucosa, Hyperplasia | 2 2 2 3 2 2 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | |
Inflammation, Subacute | |
Mineralization | |
Mucosa, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 6| 1| 4| 4| 4| 4| 2| 8| 5| 6| 3| 0| 4| 7| 4| 3| 5| 4| 4| 4| 4| 4| 3| 4|
| 4| 9| 8| 4| 4| 4| 4| 9| 3| 7| 9| 9| 7| 4| 9| 4| 3| 2| 4| 4| 4| 4| 4| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.0625% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | |
Thrombosis | |
Myocardium, Necrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Degeneration, Fatty | 2 |
Hematopoietic Cell Proliferation | 2 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + M + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + I + + + + M + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 1 2 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 2 1 1 2 |
Ectopic Thymus | |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 4 2 3 4 2 |
Cyst | X X X X X X|
Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 3 2 2 3 4 3 3 3|
Hydrometra | 3 4 3 4 |
Hyperplasia, Cystic | 3 2 3 2 2 2 3 3 3 2 2 2 3 3 3 2 3 3 3 3 2|
Inflammation, Granulomatous | 3 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 6| 1| 4| 4| 4| 4| 2| 8| 5| 6| 3| 0| 4| 7| 4| 3| 5| 4| 4| 4| 4| 4| 3| 4|
| 4| 9| 8| 4| 4| 4| 4| 9| 3| 7| 9| 9| 7| 4| 9| 4| 3| 2| 4| 4| 4| 4| 4| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.0625% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 2 2 |
Myelofibrosis | 3 2 2 |
__________________________________________________________________________|
Lymph Node | + |
Iliac, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + M + M + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 2|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 4 2 3 4 4 4 2 3 2|
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 3 |
Lymphoid Follicle, Hyperplasia | 2 3 3 2 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia, Cystic | |
Hyperplasia, Lobular | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 6| 1| 4| 4| 4| 4| 2| 8| 5| 6| 3| 0| 4| 7| 4| 3| 5| 4| 4| 4| 4| 4| 3| 4|
| 4| 9| 8| 4| 4| 4| 4| 9| 3| 7| 9| 9| 7| 4| 9| 4| 3| 2| 4| 4| 4| 4| 4| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.0625% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Inflammation, Chronic | |
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Histiocyte | 2 4 |
Inflammation, Subacute | 2 2 |
Mineralization | 2 |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | 1 1 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Phthisis Bulbi | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 2 1 1 1 |
Cyst | |
Hyperplasia, Lymphoid | 2 2 2|
Metaplasia, Osseous | 2 |
Mineralization | |
Renal Tubule, Cytoplasmic Alteration | |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Necrosis | 1 2 |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 1 1 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hyperplasia, Lymphoid | |
Inflammation, Subacute | |
Mucosa, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 4| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0.0625% | 1| | L |
| 3| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 50 |
__________________________________________________________________________|____________|
Gallbladder | A | 47 |
Dilatation | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A | 49 |
Edema | | 4 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A | 47 |
__________________________________________________________________________|____________|
Liver | + | 50 |
Basophilic Focus | | 2 2.5|
Cyst | | 1 |
Degeneration, Fatty | | 1 1.0|
Eosinophilic Focus | | 3 2.3|
Hematopoietic Cell Proliferation | | 4 2.8|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Subacute | | 2 2.5|
Mixed Cell Focus | | 3 2.7|
Centrilobular, Necrosis | | 2 2.5|
Kupffer Cell, Hyperplasia | | 7 3.0|
Kupffer Cell, Pigmentation | | 1 1.0|
Lobules, Necrosis | | 6 2.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Inflammation, Chronic | | 1 4.0|
Fat, Necrosis | | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | A | 49 |
Atrophy | | 2 4.0|
Cyst | | 3 |
Acinar Cell, Cytoplasmic Alteration | | 2 3.5|
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
Hyperplasia, Lymphoid | | 5 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Diverticulum | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Ulcer | | 5 1.8|
Mucosa, Hyperplasia | | 13 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 49 |
Edema | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 4| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0.0625% | 1| | L |
| 3| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | | 1 3.0|
Inflammation, Subacute | | 1 1.0|
Mineralization | | 1 3.0|
Mucosa, Hyperplasia | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 51 |
Inflammation, Chronic | | 1 2.0|
Mineralization | | 1 4.0|
Thrombosis | | 1 |
Myocardium, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Accessory Adrenal Cortical Nodule | | 6 2.0|
Degeneration, Fatty | | 1 2.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
__________________________________________________________________________|____________|
Islets, Pancreatic | A | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 49 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 48 |
Pars Distalis, Angiectasis | | 5 1.8|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | | 5 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Degeneration, Cystic | | 13 1.6|
Ectopic Thymus | | 1 |
Follicle, Cyst | | 2 |
Follicular Cell, Hyperplasia | | 9 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 51 |
Ectasia | 2 | 2 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 4| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0.0625% | 1| | L |
| 3| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + | 51 |
Angiectasis | | 17 2.7|
Cyst | | 11 |
Inflammation, Suppurative | | 4 4.0|
__________________________________________________________________________|____________|
Uterus | + | 51 |
Angiectasis | | 16 3.1|
Hydrometra | | 7 3.3|
Hyperplasia, Cystic | | 43 2.5|
Inflammation, Granulomatous | | 1 3.0|
Inflammation, Suppurative | | 5 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Hypercellularity | | 15 2.7|
Myelofibrosis | | 6 2.2|
__________________________________________________________________________|____________|
Lymph Node | | 6 |
Iliac, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 50 |
Hyperplasia, Lymphoid | | 8 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M | 46 |
Angiectasis | | 2 2.5|
Hematopoietic Cell Proliferation | | 1 1.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 5 |
__________________________________________________________________________|____________|
Spleen | + | 50 |
Hematopoietic Cell Proliferation | | 25 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation, Hemosiderin | | 2 2.5|
Lymphoid Follicle, Hyperplasia | | 6 2.5|
__________________________________________________________________________|____________|
Thymus | + | 46 |
Atrophy | | 4 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 4| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0.0625% | 1| | L |
| 3| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | | 1 1.0|
Hyperplasia, Lobular | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + | 51 |
Edema | | 1 3.0|
Inflammation, Subacute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
Hyperostosis | | 3 2.7|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
Compression | | 2 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | | 2 2.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Congestion | | 1 4.0|
Hemorrhage | | 3 2.0|
Hyperplasia, Lymphoid | | 6 2.0|
Infiltration Cellular, Histiocyte | | 5 2.2|
Inflammation, Subacute | | 3 2.3|
Mineralization | | 1 2.0|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 8 1.5|
__________________________________________________________________________|____________|
Nose | + | 51 |
Exudate | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 1 2.0|
Phthisis Bulbi | | 2 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 27 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 4| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0.0625% | 1| | L |
| 3| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Casts Protein | | 13 1.1|
Cyst | | 1 |
Hyperplasia, Lymphoid | | 5 2.4|
Metaplasia, Osseous | | 2 2.0|
Mineralization | | 2 2.5|
Renal Tubule, Cytoplasmic Alteration | | 2 2.5|
Renal Tubule, Dilatation | | 2 2.5|
Renal Tubule, Necrosis | | 2 1.5|
Renal Tubule, Pigmentation | | 1 2.0|
Renal Tubule, Regeneration | | 11 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + | 50 |
Edema | | 2 3.0|
Hyperplasia, Lymphoid | | 2 2.0|
Inflammation, Subacute | | 2 2.0|
Mucosa, Hyperplasia | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 4| 6| 5| 5| 6| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 5| 5| 7| 4| 4| 5| 6| 6| 4|
DAY ON TEST | 6| 4| 7| 3| 7| 0| 7| 3| 1| 4| 6| 7| 1| 4| 5| 6| 3| 3| 4| 5| 8| 2| 5| 6| 9|
| 9| 9| 2| 7| 5| 6| 6| 3| 0| 4| 9| 4| 9| 2| 4| 8| 4| 4| 4| 6| 3| 0| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.125% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + A + + + + + + + + + + + + + + + A|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 |
Degeneration, Fatty | 1 2 2 |
Developmental Malformation | |
Eosinophilic Focus | 2 1 |
Hematopoietic Cell Proliferation | 2 2 4 4 2 2 2 3 4 2 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Subacute | 4 |
Mixed Cell Focus | 4 |
Centrilobular, Necrosis | 4 3|
Kupffer Cell, Hyperplasia | 2 3 3 3 2 2 |
Kupffer Cell, Pigmentation | 3 |
Lobules, Necrosis | 3 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 3 3 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + M + + + + + + + + + + +|
Atrophy | 4 3 3 4 |
Cyst | X X X X |
Focal Cellular Change | |
Hyperplasia, Lymphoid | 3 |
Acinar Cell, Cytoplasmic Alteration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Ulcer | 2 |
Mucosa, Hyperkeratosis | 3 |
Mucosa, Hyperplasia | 2 1 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Mineralization | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 4| 6| 5| 5| 6| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 5| 5| 7| 4| 4| 5| 6| 6| 4|
DAY ON TEST | 6| 4| 7| 3| 7| 0| 7| 3| 1| 4| 6| 7| 1| 4| 5| 6| 3| 3| 4| 5| 8| 2| 5| 6| 9|
| 9| 9| 2| 7| 5| 6| 6| 3| 0| 4| 9| 4| 9| 2| 4| 8| 4| 4| 4| 6| 3| 0| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.125% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | 4 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hematopoietic Cell Proliferation | 3 2 |
Hyperplasia, Focal | 3 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + I + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + M + + + + + + + + + M|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 1 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 2 2 3 1 2 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + I + + + + + + + + + + + + + I + + + + + + + +|
Angiectasis | 2 3 3 3 2 3 |
Cyst | X X X X X X X X |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 2 2 2 4 3 2 4 3 2 4|
Hydrometra | 2 3|
Hyperplasia, Cystic | 1 2 2 2 3 3 3 1 2 3 2 2 2 2 2 3 3 3 4 2 3 |
Inflammation, Granulomatous | |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 4| 6| 5| 5| 6| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 5| 5| 7| 4| 4| 5| 6| 6| 4|
DAY ON TEST | 6| 4| 7| 3| 7| 0| 7| 3| 1| 4| 6| 7| 1| 4| 5| 6| 3| 3| 4| 5| 8| 2| 5| 6| 9|
| 9| 9| 2| 7| 5| 6| 6| 3| 0| 4| 9| 4| 9| 2| 4| 8| 4| 4| 4| 6| 3| 0| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.125% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 4 4 3 2 4 3 4 2 4 3 4 2 3|
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Hematopoietic Cell | |
Proliferation | |
Iliac, Hyperplasia, Lymphoid | 4 |
Mediastinal, Hyperplasia, Lymphoid | 4 |
Mediastinal, Inflammation, | |
Suppurative | |
Pancreatic, Hematopoietic Cell | |
Proliferation | 4 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M M + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 3 1 |
Hyperplasia, Lymphoid | 3 4 3 2 3 |
Pigmentation | 2 3 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + I + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 3 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 3 3 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 3 4 1 4 3 4 2 3 3 3 3 4 4 3 4 4 3 3 4|
Hemorrhage | 3 |
Pigmentation, Hemosiderin | 3 |
Lymphoid Follicle, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + M M + M + + + I M + + + + + + + + +|
Atrophy | 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 4| 6| 5| 5| 6| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 5| 5| 7| 4| 4| 5| 6| 6| 4|
DAY ON TEST | 6| 4| 7| 3| 7| 0| 7| 3| 1| 4| 6| 7| 1| 4| 5| 6| 3| 3| 4| 5| 8| 2| 5| 6| 9|
| 9| 9| 2| 7| 5| 6| 6| 3| 0| 4| 9| 4| 9| 2| 4| 8| 4| 4| 4| 6| 3| 0| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.125% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 3 2 1 |
Inflammation, Subacute | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 3 2 3 2 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 |
Inflammation, Chronic | |
Phthisis Bulbi | X |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | |
Hydronephrosis | |
Hyperplasia, Lymphoid | 2 3 |
Metaplasia, Osseous | 2 |
Mineralization | |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Necrosis | 3 |
Renal Tubule, Pigmentation | 2 |
Renal Tubule, Regeneration | 1 3 1 4 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Subacute | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 5| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 4| 5| 4| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 7| 3| 6| 5| 6| 4| 6| 4| 4| 4| 6| 0| 4| 4| 2| 5| 8| 8| 0| 1| 4| 4| 4| 4| 4| |
| 7| 7| 9| 1| 7| 4| 9| 4| 4| 9| 9| 2| 4| 4| 6| 1| 0| 6| 1| 5| 4| 9| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.125% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + + I| 45 |
Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + M + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Basophilic Focus | 3| 2 2.0|
Degeneration, Fatty | | 3 1.7|
Developmental Malformation | X | 1 |
Eosinophilic Focus | 2 2 2| 5 1.8|
Hematopoietic Cell Proliferation | 2 3 2 1 2 | 15 2.5|
Hyperplasia, Lymphoid | 2| 2 2.0|
Inflammation, Subacute | | 1 4.0|
Mixed Cell Focus | | 1 4.0|
Centrilobular, Necrosis | | 2 3.5|
Kupffer Cell, Hyperplasia | 2 2 3 3 3 2 | 12 2.5|
Kupffer Cell, Pigmentation | | 1 3.0|
Lobules, Necrosis | 3 1 1 1| 6 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Fat, Necrosis | 3 | 5 3.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Atrophy | 4 | 5 3.6|
Cyst | X | 5 |
Focal Cellular Change | 2 2 2 2| 4 2.0|
Hyperplasia, Lymphoid | 2 | 2 2.5|
Acinar Cell, Cytoplasmic Alteration | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 | 1 1.0|
Ulcer | 2 2 | 3 2.0|
Mucosa, Hyperkeratosis | | 1 3.0|
Mucosa, Hyperplasia | 3 2 | 6 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 5| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 4| 5| 4| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 7| 3| 6| 5| 6| 4| 6| 4| 4| 4| 6| 0| 4| 4| 2| 5| 8| 8| 0| 1| 4| 4| 4| 4| 4| |
| 7| 7| 9| 1| 7| 4| 9| 4| 4| 9| 9| 2| 4| 4| 6| 1| 0| 6| 1| 5| 4| 9| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.125% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Edema | 2 | 2 2.0|
Mineralization | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
Mineralization | | 1 4.0|
Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | X X 2| 4 2.0|
Hematopoietic Cell Proliferation | | 2 2.5|
Hyperplasia, Focal | | 1 3.0|
Hypertrophy, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2| 3 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + I + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + I + + + + + + + + + +| 46 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia, Focal | 1 2 1 1 | 8 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 1 2 2 2 1 1 | 14 1.8|
Follicle, Cyst | X | 2 |
Follicular Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 3.0|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 4 3 2 3 | 11 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 5| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 4| 5| 4| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 7| 3| 6| 5| 6| 4| 6| 4| 4| 4| 6| 0| 4| 4| 2| 5| 8| 8| 0| 1| 4| 4| 4| 4| 4| |
| 7| 7| 9| 1| 7| 4| 9| 4| 4| 9| 9| 2| 4| 4| 6| 1| 0| 6| 1| 5| 4| 9| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.125% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | X X X X X X X X| 16 |
Inflammation, Suppurative | 4 3 4 4 4 | 6 3.8|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 4 2 4 4 1 | 17 3.0|
Hydrometra | 3 3 | 4 2.8|
Hyperplasia, Cystic | 3 3 3 2 2 2 2 3 2 2 2 3 2 2 2 2 2 2 3 2 2 2 3 2| 45 2.3|
Inflammation, Granulomatous | 3 | 1 3.0|
Inflammation, Suppurative | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 4 2 3 3 2 3 3 3 2 2 | 25 3.0|
Myelofibrosis | 2 2 2 2 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 9 |
Iliac, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Iliac, Hyperplasia, Lymphoid | 3 3 | 3 3.3|
Mediastinal, Hyperplasia, Lymphoid | 2 3 | 3 3.0|
Mediastinal, Inflammation, | | |
Suppurative | 3 | 1 3.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation | | 1 4.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hyperplasia, Lymphoid | 4 4 4 3 | 5 3.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + A + + + + + + + + + +| 46 |
Hematopoietic Cell Proliferation | 2 | 2 2.5|
Hemorrhage | | 2 2.0|
Hyperplasia, Lymphoid | 3 2 2 2 3 4 | 11 2.8|
Pigmentation | 3 2 2 | 7 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Hemorrhage | 4 1 1 | 4 1.8|
Hyperplasia, Lymphoid | 2 2 2 3 3 3 | 9 2.6|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 4 2 3 4 2 3 2 3 4 3 3 4 3 1 4 2 3| 39 3.1|
Hemorrhage | | 1 3.0|
Pigmentation, Hemosiderin | 2 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 5| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 4| 5| 4| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 7| 3| 6| 5| 6| 4| 6| 4| 4| 4| 6| 0| 4| 4| 2| 5| 8| 8| 0| 1| 4| 4| 4| 4| 4| |
| 7| 7| 9| 1| 7| 4| 9| 4| 4| 9| 9| 2| 4| 4| 6| 1| 0| 6| 1| 5| 4| 9| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.125% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoid Follicle, Hyperplasia | 3 3 3 | 4 2.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + M + + + +| 42 |
Atrophy | 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Hyperplasia, Cystic | 3 1 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 1 2.0|
Hemorrhage | 2 1 | 3 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 | 5 2.0|
Inflammation, Subacute | 3 3 | 2 3.0|
Thrombosis | X | 1 |
Alveolar Epithelium, Hyperplasia | 2 1 2 1 1 1 1 3 | 15 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + | 7 |
Cataract | 2 | 2 2.0|
Inflammation, Chronic | 3 3 3 3 2 | 5 2.8|
Phthisis Bulbi | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 5| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 4| 5| 4| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 7| 3| 6| 5| 6| 4| 6| 4| 4| 4| 6| 0| 4| 4| 2| 5| 8| 8| 0| 1| 4| 4| 4| 4| 4| |
| 7| 7| 9| 1| 7| 4| 9| 4| 4| 9| 9| 2| 4| 4| 6| 1| 0| 6| 1| 5| 4| 9| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.125% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Casts Protein | 1 1 1 1| 4 1.0|
Hydronephrosis | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 4 | 4 3.0|
Metaplasia, Osseous | | 1 2.0|
Mineralization | 1 | 1 1.0|
Renal Tubule, Dilatation | 3 | 2 2.5|
Renal Tubule, Necrosis | | 1 3.0|
Renal Tubule, Pigmentation | | 1 2.0|
Renal Tubule, Regeneration | 2| 6 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 2 | 3 2.0|
Inflammation, Subacute | 2 | 1 2.0|
Mucosa, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7|
| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Liver | + + A + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 |
Clear Cell Focus | 2 3 3 2 4 |
Eosinophilic Focus | 2 2 |
Hematopoietic Cell Proliferation | 2|
Hyperplasia, Lymphoid | 2 |
Inflammation, Subacute | 1 |
Mixed Cell Focus | X 3 |
Kupffer Cell, Hyperplasia | 3|
Kupffer Cell, Pigmentation | 2|
Lobules, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | |
Acinar Cell, Cytoplasmic Alteration | 4 |
__________________________________________________________________________|
Salivary Glands | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 1 |
Mucosa, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Tooth | + + + + + |
Dysplasia | 3 2 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + A + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7|
| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 1 1 2 2 1 1 |
Capsule, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 4 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + M + + + M + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + A + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + A + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 1 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Cyst | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Dilatation | 4 |
__________________________________________________________________________|
Epididymis | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | X |
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + A + + + + + + + + + + M + + + + + + + + + + +|
Atrophy | 3 3 |
Ectasia | 3 3 3 3 3 3 3 4 2 3|
Inflammation, Chronic | 2 3 4 3 3 4 2 4 2 |
Inflammation, Suppurative | 2 3 4 |
__________________________________________________________________________|
Prostate | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + A + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3 4 3 3 3 |
Hemorrhage | |
Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Testes | + + A + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 2|
__________________________________________________________________________|
Lymph Node | + + |
Inguinal, Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7|
| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Pigmentation | 2 |
Renal, Hemorrhage | 1 |
Renal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + A + + + + + + + + + I + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Pigmentation | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 3 2 1 2 3 2 1 2 |
Hyperplasia, Lymphoid | 2 2 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 4|
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia | 3 |
__________________________________________________________________________|
Thymus | + + M M + M + + + + + + + + M + + M + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Histiocyte | 3 2 2 2 |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | 2 2 1 2 |
__________________________________________________________________________|
Nose | + + A + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Foreign Body | |
__________________________________________________________________________|
Trachea | + + A + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + A + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7|
| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Casts Protein | 1 1 1 2 3|
Cyst | X X X X X X |
Hyperplasia, Lymphoid | 2 |
Metaplasia, Osseous | |
Mineralization | 2 3 1 2 2 3 2 2 1 3 1 2 2 2 2 3 1 |
Renal Tubule, Atrophy | 1 |
Renal Tubule, Dilatation | 1 1 |
Renal Tubule, Necrosis | |
Renal Tubule, Regeneration | 2 1 1 2 1 1 1 1 1 2 1 1 2 2 2 2 1 1 2 2 1 2 1 3|
__________________________________________________________________________|
Urethra | + |
Concretion | 3 |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 6| 6| 9| 6| 6| 6| 6| 6| 4| 6| 9| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + I + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Peyer's Patch, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + I + + + + + + + + + + + + +| 48 |
Peyer's Patch, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | 2 3 | 3 2.7|
Clear Cell Focus | 2 | 6 2.7|
Eosinophilic Focus | 3 3 | 4 2.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Subacute | 2 1 | 3 1.3|
Mixed Cell Focus | 3 2 2 | 5 2.5|
Kupffer Cell, Hyperplasia | | 1 3.0|
Kupffer Cell, Pigmentation | | 1 2.0|
Lobules, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + +| 3 |
Fat, Necrosis | 2 3| 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 2.0|
Cyst | X | 1 |
Acinar Cell, Cytoplasmic Alteration | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | | 2 1.5|
Mucosa, Hyperplasia | 1 | 4 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + +| 13 |
Dysplasia | 3 2 3 2 2 3 2 2| 13 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 6| 6| 9| 6| 6| 6| 6| 6| 4| 6| 9| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + I + + + + + + + + + +| 48 |
Accessory Adrenal Cortical Nodule | | 2 |
Hyperplasia, Focal | 2 3 2 | 3 2.3|
Hypertrophy, Focal | 1 2 1 2 3 2 1 | 14 1.6|
Capsule, Hyperplasia | 3 | 5 2.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 3 3 3 2 4 4 3 | 14 2.9|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | X | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 1 3 2 2 | 8 1.9|
Follicle, Cyst | X | 2 |
Follicular Cell, Hyperplasia | 1 1 | 6 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
Dilatation | 3 | 2 3.5|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hypospermia | | 1 |
Spermatocele | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | | 2 3.0|
Ectasia | 3 3 2 2 2 2 4 3 2 3 2 2 2 3 | 24 2.7|
Inflammation, Chronic | 2 3 2 3 4 4 3 4 2 2 2 2 3 | 22 2.9|
Inflammation, Suppurative | 3 2 2 2 3 | 8 2.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 4 4 3 4 3 3 3 4 | 15 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 6| 6| 9| 6| 6| 6| 6| 6| 4| 6| 9| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hemorrhage | 3 2 | 2 2.5|
Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Seminiferous Tubule, Atrophy | 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hypercellularity | 3 | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Inguinal, Hyperplasia, Lymphoid | 2 | 2 2.0|
Inguinal, Pigmentation | | 1 2.0|
Renal, Hemorrhage | | 1 1.0|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + M + + +| 46 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Pigmentation | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | 2 2 2 3 1 3 | 17 1.9|
Hyperplasia, Lymphoid | 2 | 4 2.3|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 3 2 1 2 | 8 2.5|
Lymphoid Follicle, Atrophy | | 1 3.0|
Lymphoid Follicle, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +| 44 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 6| 6| 9| 6| 6| 6| 6| 6| 4| 6| 9| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | 1 | 1 1.0|
Hyperplasia, Lymphoid | 1 | 3 1.7|
Infiltration Cellular, Histiocyte | 3 2 | 6 2.3|
Thrombosis | | 1 |
Alveolar Epithelium, Hyperplasia | 1 1 | 6 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Exudate | 2 | 1 2.0|
Foreign Body | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + | 22 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Casts Protein | 1 | 6 1.5|
Cyst | X X X X X X| 12 |
Hyperplasia, Lymphoid | 2 2| 3 2.0|
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | 3 2 2 1 2 2 3 2 2 2 1 1 2 2 2 2 1 2| 35 1.9|
Renal Tubule, Atrophy | | 1 1.0|
Renal Tubule, Dilatation | | 2 1.0|
Renal Tubule, Necrosis | 3 | 1 3.0|
Renal Tubule, Regeneration | 1 2 1 1 2 2 3 1 2 2 1 1 1 1 1 2 1 1 2| 43 1.5|
__________________________________________________________________________|____________|
Urethra | | 1 |
Concretion | | 1 3.0|
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 3 | 2 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 3|
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 2| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0312% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + + + + + + + + + + A + + + + + A + M +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Edema | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + A + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | 2 3 3 1 X |
Congestion | |
Eosinophilic Focus | 2 X X 3 |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Subacute | |
Mixed Cell Focus | 3 |
Thrombosis | |
Hepatocyte, Nuclear Alteration | |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Hyperplasia | |
Lobules, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Acinar Cell, Cytoplasmic Alteration | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 3|
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 2 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 3|
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 2| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0312% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X |
Hyperplasia, Focal | 1 |
Hypertrophy, Focal | 1 3 1 1 3 3 1 1 |
Vacuolization Cytoplasmic | 3 |
Capsule, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + I + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 4 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + I + + M + + + + + + + + + + + + M + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + M + + + + + + + + +|
Pars Distalis, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 2 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Dilatation | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Ectasia | 3 2 3 3 2 2 3 3 2|
Inflammation, Chronic | 4 2 2 3 4 4 2 |
Inflammation, Suppurative | 4 3 2 3 1 2 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3 3 3 3 4 |
Hemorrhage | 3|
Inflammation, Chronic | 3|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 2 2 3 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 3|
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 2| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0312% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Atrophy | 3 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 |
Pigmentation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + I + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 1 2 2 1 2 3 3 |
Hyperplasia, Lymphoid | 3 3 2 3 2 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 1 2 2 2 3 4 3 3 |
Lymphoid Follicle, Atrophy | 3 3 |
Red Pulp, Atrophy | 3 3 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + M + + + + + +|
Atrophy | 3 3 |
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Spinal Cord | +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 2 1 4 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 3|
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 2| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0312% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | 1 2 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Inflammation, Chronic | |
Phthisis Bulbi | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + |
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 2 1 1 1 1 1|
Cyst | X X X X X X X X|
Hydronephrosis | 2 2 |
Hyperplasia, Lymphoid | 2 2 3 2 |
Inflammation, Suppurative | |
Metaplasia, Osseous | |
Mineralization | 2 1 2 2 2 2 2 2 2 2 1 2 1 |
Papilla, Necrosis | |
Renal Tubule, Casts Protein | 1|
Renal Tubule, Dilatation | |
Renal Tubule, Necrosis | 4 |
Renal Tubule, Regeneration | 1 2 1 2 3 2 2 2 1 2 3 1 1 1 1 2 1 1 1|
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Suppurative | |
Mucosa, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 6| 4| 7| 4| 3| 3| 0| 2| 3| 8| 3| 3| 3|
| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 3| 8| 6| 7| 7| 5| 5| 7| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0312% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + M + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + M + + + + +|
Edema | 2 2 2 2|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 |
Clear Cell Focus | 3 2|
Congestion | 4 |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Subacute | 1 3|
Mixed Cell Focus | 2 |
Thrombosis | X |
Hepatocyte, Nuclear Alteration | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 4 |
Kupffer Cell, Hyperplasia | 2 3 |
Lobules, Necrosis | 1 4 3 |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Acinar Cell, Cytoplasmic Alteration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Mucosa, Hyperplasia | 1|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | |
Mucosa, Hyperplasia | 2 2 |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 6| 4| 7| 4| 3| 3| 0| 2| 3| 8| 3| 3| 3|
| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 3| 8| 6| 7| 7| 5| 5| 7| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0312% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 X |
Hyperplasia, Focal | 2 1 |
Hypertrophy, Focal | 2 2 3 1 2 1 3 1 1|
Vacuolization Cytoplasmic | |
Capsule, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 2 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + I + + + + + + M + + + + + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 1 1 2 2 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Dilatation | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | X 2|
__________________________________________________________________________|
Preputial Gland | I + + + + + + + + + + + + + + + + + + + + + + + M|
Angiectasis | |
Ectasia | 2 3 3 2 3 3 3 3 |
Inflammation, Chronic | 3 2 2 2 4 2 2 2 2 |
Inflammation, Suppurative | 2 3 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 4 |
Hemorrhage | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 2 3 3 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 6| 4| 7| 4| 3| 3| 0| 2| 3| 8| 3| 3| 3|
| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 3| 8| 6| 7| 7| 5| 5| 7| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0312% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Atrophy | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 1 2 |
Hemorrhage | 2 1 1 1 2 3 1 1|
Hyperplasia, Lymphoid | 2 2 3 2 2 4 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 2 2 2 3 3 4 3 |
Lymphoid Follicle, Atrophy | 2 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
Atrophy | 2 |
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 4 3 1 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 6| 4| 7| 4| 3| 3| 0| 2| 3| 8| 3| 3| 3|
| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 3| 8| 6| 7| 7| 5| 5| 7| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0312% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Subacute | 3 |
Alveolar Epithelium, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 |
Inflammation, Chronic | 2 |
Phthisis Bulbi | X |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 2 2 1 |
Cyst | X X X X X |
Hydronephrosis | 2|
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | |
Metaplasia, Osseous | 2 |
Mineralization | 2 2 2 2 2 2 1 1 2 2 2 2 3 2 2 1|
Papilla, Necrosis | |
Renal Tubule, Casts Protein | |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Necrosis | |
Renal Tubule, Regeneration | 2 2 2 1 2 1 2 2 1 1 2 3 3 3 2 2 1 2 1 2 2 1|
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Suppurative | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 3| | |
DAY ON TEST | 6| | |
| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 1| | A |
0.0312% | 1| | L |
| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 50 |
__________________________________________________________________________|____________|
Gallbladder | M | 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 49 |
Edema | | 4 2.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M | 48 |
Amyloid Deposition | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + | 51 |
Basophilic Focus | | 3 2.0|
Clear Cell Focus | | 7 2.3|
Congestion | | 1 4.0|
Eosinophilic Focus | | 4 2.5|
Hematopoietic Cell Proliferation | | 2 2.5|
Inflammation, Subacute | | 2 2.0|
Mixed Cell Focus | | 2 2.5|
Thrombosis | | 1 |
Hepatocyte, Nuclear Alteration | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| | 1 4.0|
Kupffer Cell, Hyperplasia | | 2 2.5|
Lobules, Necrosis | | 4 2.5|
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Atrophy | | 1 2.0|
Acinar Cell, Cytoplasmic Alteration | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Diverticulum | | 1 3.0|
Mucosa, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Edema | | 1 2.0|
Erosion | | 1 2.0|
Mucosa, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Dysplasia | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 3| | |
DAY ON TEST | 6| | |
| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 1| | A |
0.0312% | 1| | L |
| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 51 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Accessory Adrenal Cortical Nodule | | 4 2.0|
Hyperplasia, Focal | | 3 1.3|
Hypertrophy, Focal | | 17 1.8|
Vacuolization Cytoplasmic | | 1 3.0|
Capsule, Hyperplasia | | 4 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 50 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 50 |
Hyperplasia | | 12 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + | 48 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | M | 46 |
Pars Distalis, Cyst | | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Degeneration, Cystic | | 8 2.0|
Follicle, Cyst | | 2 |
Follicular Cell, Hyperplasia | | 6 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
Dilatation | | 2 3.0|
__________________________________________________________________________|____________|
Epididymis | + | 51 |
Spermatocele | | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 49 |
Angiectasis | | 1 3.0|
Ectasia | 2 | 18 2.6|
Inflammation, Chronic | | 16 2.6|
Inflammation, Suppurative | 2 | 13 2.4|
__________________________________________________________________________|____________|
Prostate | + | 51 |
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 3| | |
DAY ON TEST | 6| | |
| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 1| | A |
0.0312% | 1| | L |
| 6| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 51 |
Dilatation | | 10 3.2|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + | 51 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Hypercellularity | 2 | 12 2.6|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Iliac, Hyperplasia, Lymphoid | 3 | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 49 |
Atrophy | | 2 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | | 3 2.7|
Pigmentation | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 49 |
Atrophy | | 1 2.0|
Hematopoietic Cell Proliferation | | 4 1.8|
Hemorrhage | | 15 1.7|
Hyperplasia, Lymphoid | | 12 2.5|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + | 51 |
Hematopoietic Cell Proliferation | 2 | 20 2.6|
Lymphoid Follicle, Atrophy | 3 | 4 2.8|
Red Pulp, Atrophy | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + | 48 |
Atrophy | 2 | 4 2.5|
Congestion | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
__________________________________________________________________________|____________|
Skin | + | 51 |
Inflammation, Suppurative | | 1 4.0|
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 3| | |
DAY ON TEST | 6| | |
| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 1| | A |
0.0312% | 1| | L |
| 6| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
Hyperostosis | | 2 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
Hemorrhage | | 1 2.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Congestion | 3 | 1 3.0|
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | | 8 2.3|
Inflammation, Subacute | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 7 2.1|
__________________________________________________________________________|____________|
Nose | + | 51 |
Exudate | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Phthisis Bulbi | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 25 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Casts Protein | | 11 1.3|
Cyst | | 13 |
Hydronephrosis | | 3 2.0|
Hyperplasia, Lymphoid | | 4 2.3|
Inflammation, Suppurative | 4 | 1 4.0|
Metaplasia, Osseous | | 1 2.0|
Mineralization | | 29 1.8|
Papilla, Necrosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 3| | |
DAY ON TEST | 6| | |
| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 1| | A |
0.0312% | 1| | L |
| 6| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Casts Protein | | 1 1.0|
Renal Tubule, Dilatation | | 1 1.0|
Renal Tubule, Necrosis | | 1 4.0|
Renal Tubule, Regeneration | | 41 1.7|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 51 |
Edema | | 1 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
Mucosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0625% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + I + + + M + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + M + + + + +|
Edema | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 X |
Clear Cell Focus | 3 2 |
Cyst | |
Developmental Malformation | |
Eosinophilic Focus | 2 2 3 2 X|
Inflammation, Subacute | 3 1 1 2 |
Mineralization | 2 |
Mixed Cell Focus | |
Necrosis | |
Hepatocyte, Nuclear Alteration | 2 2 |
Kupffer Cell, Hyperplasia | 3|
Kupffer Cell, Pigmentation | 3|
Lobules, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinar Cell, Cytoplasmic Alteration | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0625% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia, Focal | 1 2 |
Hypertrophy, Focal | 1 2 1 2 3 2 1 1 2 |
Capsule, Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 1 2 1|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 3 |
Ectasia | 2 3 2 3 2 2 3 3 3 3 2 2 2 3 3 3 2|
Hyperplasia | |
Inflammation, Chronic | 2 4 4 4 2 2 3 2 4 |
Inflammation, Suppurative | 3 3 3 3 4 2 3 3 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 3 3 3 2 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0625% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 3 2 2 2 |
__________________________________________________________________________|
Lymph Node | + |
Inguinal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 1 2 2 1 1 3 4 3 2 3|
Hyperplasia, Lymphoid | 3 3 2 3 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 3 3 3 2 4|
Lymphoid Follicle, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + I + + + + + + + + + + + + + M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | X |
Inflammation, Subacute | |
Inflammation, Suppurative | 4 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 3 2 2|
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 2 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0625% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Inflammation, Chronic | |
Cornea, Hyperplasia | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 3 1 3 3 1 1|
Cyst | X X X|
Hydronephrosis | 2 |
Hyperplasia, Lymphoid | 2 2 2 2 |
Inflammation, Suppurative | |
Metaplasia, Osseous | 3 2|
Mineralization | 2 2 2 2 1 2 2 2 2 2 1 2 2 3 1 2 |
Renal Tubule, Atrophy | |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Pigmentation | 3|
Renal Tubule, Regeneration | 2 1 2 3 1 1 3 3 2 1 1 2 2 1 1 1 2 1 2 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 0| 7| 7| 7| 6| 5| 7| 6| 7| 6| 6| |
DAY ON TEST | 3| 3| 6| 8| 3| 3| 6| 3| 3| 7| 3| 3| 6| 3| 4| 3| 3| 3| 6| 3| 3| 6| 3| 6| 6| |
| 7| 8| 9| 7| 8| 8| 2| 8| 8| 2| 8| 8| 9| 8| 5| 8| 8| 8| 9| 6| 8| 8| 8| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.0625% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + M M + + + + + M + + +| 45 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + A + + + + +| 48 |
Edema | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Basophilic Focus | 3 | 3 2.5|
Clear Cell Focus | 2| 3 2.3|
Cyst | X | 1 |
Developmental Malformation | X | 1 |
Eosinophilic Focus | 2 2 | 7 2.2|
Inflammation, Subacute | 1 | 5 1.6|
Mineralization | 1 | 2 1.5|
Mixed Cell Focus | 2 | 1 2.0|
Necrosis | 4 | 1 4.0|
Hepatocyte, Nuclear Alteration | 2 | 3 2.0|
Kupffer Cell, Hyperplasia | 3 | 2 3.0|
Kupffer Cell, Pigmentation | 2 | 2 2.5|
Lobules, Necrosis | 2 1 4 | 4 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Acinar Cell, Cytoplasmic Alteration | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 1.0|
Mucosa, Hyperplasia | 2 3 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Edema | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 0| 7| 7| 7| 6| 5| 7| 6| 7| 6| 6| |
DAY ON TEST | 3| 3| 6| 8| 3| 3| 6| 3| 3| 7| 3| 3| 6| 3| 4| 3| 3| 3| 6| 3| 3| 6| 3| 6| 6| |
| 7| 8| 9| 7| 8| 8| 2| 8| 8| 2| 8| 8| 9| 8| 5| 8| 8| 8| 9| 6| 8| 8| 8| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.0625% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + | 4 |
Dysplasia | 3 2 | 4 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X | 3 |
Hyperplasia, Focal | 3 2 2 2 1| 7 1.9|
Hypertrophy, Focal | 1 2 1 3 2 1 1| 16 1.6|
Capsule, Hyperplasia | 3 2 | 5 2.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 2 2 2 2 2| 12 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + M M + + + + + + + + + +| 47 |
Cyst | X X | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Degeneration, Cystic | 2 1 1 1 2 | 10 1.4|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 4.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Angiectasis | 3 | 1 3.0|
Atrophy | | 1 3.0|
Ectasia | 2 3 3 2 3 2 3 | 24 2.5|
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | 3 2 4 2 2 3 3 2 2 2 2 | 20 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 0| 7| 7| 7| 6| 5| 7| 6| 7| 6| 6| |
DAY ON TEST | 3| 3| 6| 8| 3| 3| 6| 3| 3| 7| 3| 3| 6| 3| 4| 3| 3| 3| 6| 3| 3| 6| 3| 6| 6| |
| 7| 8| 9| 7| 8| 8| 2| 8| 8| 2| 8| 8| 9| 8| 5| 8| 8| 8| 9| 6| 8| 8| 8| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.0625% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 3 2 3 2 3 | 15 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 3 3 3 | 11 2.8|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Seminiferous Tubule, Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 2 3 2 2 2 | 10 2.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 5 |
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation | 2 2 2 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Angiectasis | | 2 2.5|
Hematopoietic Cell Proliferation | 2 3 | 3 2.3|
Hemorrhage | 2 1 1 1 4 1| 16 2.0|
Hyperplasia, Lymphoid | 3 3 | 7 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 1 1 2 3 2 3 | 15 2.5|
Lymphoid Follicle, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + M + M + + + M + + + M M + + + + + + + M + +| 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 1| 2 1.5|
Cyst Epithelial Inclusion | | 1 |
Inflammation, Subacute | 1 | 1 1.0|
Inflammation, Suppurative | | 1 4.0|
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 0| 7| 7| 7| 6| 5| 7| 6| 7| 6| 6| |
DAY ON TEST | 3| 3| 6| 8| 3| 3| 6| 3| 3| 7| 3| 3| 6| 3| 4| 3| 3| 3| 6| 3| 3| 6| 3| 6| 6| |
| 7| 8| 9| 7| 8| 8| 2| 8| 8| 2| 8| 8| 9| 8| 5| 8| 8| 8| 9| 6| 8| 8| 8| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.0625% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 1.5|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 3 | 5 2.4|
Thrombosis | X | 1 |
Alveolar Epithelium, Hyperplasia | 3 | 5 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 4 |
Cataract | 2 | 1 2.0|
Inflammation, Chronic | 2 4 3 | 3 3.0|
Cornea, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + +| 28 |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts Protein | 1 1 2 | 10 1.7|
Cyst | X X X X X | 8 |
Hydronephrosis | 2| 2 2.0|
Hyperplasia, Lymphoid | 2 | 5 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
Metaplasia, Osseous | | 2 2.5|
Mineralization | 1 2 2 2 1 2 2 2 1 2 2 2 2 1 2 2 2 2 1 1 2| 37 1.8|
Renal Tubule, Atrophy | 2 | 1 2.0|
Renal Tubule, Dilatation | 1 2 | 3 1.3|
Renal Tubule, Pigmentation | | 1 3.0|
Renal Tubule, Regeneration | 1 1 1 2 2 1 1 2 2 1 1 1 2 2 1 1 2 2 2 2 2 2 1| 45 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 5| 7| 6| 4| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 2|
DAY ON TEST | 6| 3| 3| 8| 0| 3| 9| 3| 6| 4| 3| 6| 3| 2| 3| 6| 9| 2| 3| 3| 3| 1| 3| 3| 4|
| 9| 8| 8| 9| 3| 8| 2| 8| 9| 5| 8| 5| 8| 5| 8| 9| 3| 5| 8| 8| 8| 5| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.125% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Edema | 2 2 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + M + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 3 |
Clear Cell Focus | |
Eosinophilic Focus | 2 |
Hematopoietic Cell Proliferation | 3 4 |
Hemorrhage | 1 |
Inflammation, Subacute | 1 |
Mineralization | 1 3 |
Mixed Cell Focus | 3 3 |
Necrosis | |
Kupffer Cell, Hyperplasia | 3 2 3 |
Kupffer Cell, Pigmentation | 1 2 |
Lobules, Necrosis | 3 4 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Acinar Cell, Cytoplasmic Alteration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + M|
Ulcer | 1 |
Mucosa, Hyperplasia | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Ectopic Tissue | X |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 4 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 5| 7| 6| 4| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 2|
DAY ON TEST | 6| 3| 3| 8| 0| 3| 9| 3| 6| 4| 3| 6| 3| 2| 3| 6| 9| 2| 3| 3| 3| 1| 3| 3| 4|
| 9| 8| 8| 9| 3| 8| 2| 8| 9| 5| 8| 5| 8| 5| 8| 9| 3| 5| 8| 8| 8| 5| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.125% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | 1 3 3 2 1 1 |
Capsule, Hyperplasia | 3 2 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia | 3 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + M + + + + + + + M|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | |
Inflammation, Chronic | 2 |
Spermatocele | X X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Ectasia | 3 3 4 2 4 3 2 3 2 3|
Hyperplasia | |
Inflammation, Chronic | 2 4 3 2 2 3 |
Inflammation, Granulomatous | 2 |
Inflammation, Suppurative | 2 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + M + + + M + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3 3 |
Fibrosis | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 4 2 3 2 3 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 5| 7| 6| 4| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 2|
DAY ON TEST | 6| 3| 3| 8| 0| 3| 9| 3| 6| 4| 3| 6| 3| 2| 3| 6| 9| 2| 3| 3| 3| 1| 3| 3| 4|
| 9| 8| 8| 9| 3| 8| 2| 8| 9| 5| 8| 5| 8| 5| 8| 9| 3| 5| 8| 8| 8| 5| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.125% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + |
Inguinal, Hematopoietic Cell | |
Proliferation | 2 |
Inguinal, Hyperplasia, Lymphoid | 3 2 |
Mediastinal, Hematopoietic Cell | |
Proliferation | 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 2 3 |
Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 2 |
Hemorrhage | 2 2 3 2 2 2 1 3 2 |
Hyperplasia, Lymphoid | 4 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 4 1 4 3 2 |
Infiltration Cellular, Mast Cell | |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + I M M + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 5| 7| 6| 4| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 2|
DAY ON TEST | 6| 3| 3| 8| 0| 3| 9| 3| 6| 4| 3| 6| 3| 2| 3| 6| 9| 2| 3| 3| 3| 1| 3| 3| 4|
| 9| 8| 8| 9| 3| 8| 2| 8| 9| 5| 8| 5| 8| 5| 8| 9| 3| 5| 8| 8| 8| 5| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.125% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | 2 2 1 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 2 2 2 2 |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | 3 3 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Cataract | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 |
Cyst | X X X X X |
Hydronephrosis | 2 |
Hyperplasia, Lymphoid | |
Mineralization | 1 1 1 2 1 2 3 2 1 1 2 2 2 |
Renal Tubule, Atrophy | 4 |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Regeneration | 1 1 1 1 1 2 1 1 1 1 1 2 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 9| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 4| 3| 3| 3| 3| |
| 7| 8| 8| 8| 0| 8| 8| 9| 8| 2| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 1| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.125% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M I + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + M + + + + + + M + I + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + M + + + + + + M + + + + + + + + + M +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Edema | 2 2 2 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | 3 | 3 2.7|
Clear Cell Focus | 2 2 | 2 2.0|
Eosinophilic Focus | X 3 | 3 2.5|
Hematopoietic Cell Proliferation | 3 2 | 4 3.0|
Hemorrhage | | 1 1.0|
Inflammation, Subacute | 2 1 | 3 1.3|
Mineralization | | 2 2.0|
Mixed Cell Focus | | 2 3.0|
Necrosis | 4 | 1 4.0|
Kupffer Cell, Hyperplasia | 3 2 | 5 2.6|
Kupffer Cell, Pigmentation | | 2 1.5|
Lobules, Necrosis | 1 | 3 2.7|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 4.0|
Acinar Cell, Cytoplasmic Alteration | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ulcer | 1 4 | 3 2.0|
Mucosa, Hyperplasia | 4 2 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectopic Tissue | | 1 |
Mucosa, Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Tooth | + + | 3 |
Dysplasia | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 9| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 4| 3| 3| 3| 3| |
| 7| 8| 8| 8| 0| 8| 8| 9| 8| 2| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 1| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.125% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | | 3 2.3|
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | X| 2 |
Hyperplasia, Focal | 1 | 3 1.7|
Hypertrophy, Focal | 3 2 1| 9 1.9|
Capsule, Hyperplasia | 2 | 5 2.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 1.0|
Hyperplasia | 3 2 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Pars Distalis, Cyst | X X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 3 2 2 1| 6 2.0|
Follicular Cell, Hyperplasia | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hypospermia | X | 1 |
Inflammation, Chronic | | 1 2.0|
Spermatocele | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectasia | 4 2 3 4 3 3 2 2 2 3 3| 21 2.9|
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | 2 2 2 2 2 4| 12 2.5|
Inflammation, Granulomatous | | 1 2.0|
Inflammation, Suppurative | 4 4 3 3 3 3 2 3| 11 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 9| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 4| 3| 3| 3| 3| |
| 7| 8| 8| 8| 0| 8| 8| 9| 8| 2| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 1| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.125% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 3 3 4 4 | 8 3.3|
Fibrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Seminiferous Tubule, Atrophy | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hypercellularity | 3 3 4 2 4 2 | 13 2.8|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 6 |
Inguinal, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | 3 | 3 2.7|
Mediastinal, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + I + + + + + M + + + + + + + + + +| 46 |
Hematopoietic Cell Proliferation | 2 | 2 2.5|
Hyperplasia, Lymphoid | 2 2 | 5 2.2|
Pigmentation | 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 2| 2 2.0|
Hematopoietic Cell Proliferation | 1 2 2 | 5 2.0|
Hemorrhage | 3 2 2 3 3 3 1 1 2 3 1 2 1| 22 2.1|
Hyperplasia, Lymphoid | 3 3 2 | 4 3.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 1 4 1 4 3 2 3 2 1 | 17 2.5|
Infiltration Cellular, Mast Cell | 3| 1 3.0|
Lymphoid Follicle, Atrophy | 2 | 1 2.0|
Lymphoid Follicle, Hyperplasia | 2 | 1 2.0|
Red Pulp, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M M + + + + + + + + + + + + + + + I + + + M +| 42 |
Atrophy | 2 3 | 4 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 9| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 4| 3| 3| 3| 3| |
| 7| 8| 8| 8| 0| 8| 8| 9| 8| 2| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 1| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.125% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperostosis | 3 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Compression | X | 1 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 3 1.7|
Hyperplasia, Lymphoid | 3| 1 3.0|
Infiltration Cellular, Histiocyte | 2 2 4 2 2| 9 2.2|
Thrombosis | X | 2 |
Alveolar Epithelium, Hyperplasia | 3 1 1 1 | 8 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Exudate | 2 | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + | 9 |
Cataract | 2 | 2 2.5|
Inflammation, Chronic | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + +| 32 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Casts Protein | 1 2 | 4 1.3|
Cyst | X X X X X X | 11 |
Hydronephrosis | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Mineralization | 1 2 2 2 3 2 1 1 1 2 1 1 1 2 1 2 2| 30 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05103-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/13/94
Route: DOSED FEED Time: 14:35:48
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 9| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 4| 3| 3| 3| 3| |
| 7| 8| 8| 8| 0| 8| 8| 9| 8| 2| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 1| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.125% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Atrophy | 1 | 2 2.5|
Renal Tubule, Dilatation | | 1 1.0|
Renal Tubule, Hyperplasia | 2 | 2 2.0|
Renal Tubule, Regeneration | 1 1 3 2 1 2 1 1 2 1 1 1 1 1 1 1 3 1 1 3 2| 36 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
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---------- END OF REPORT ----------
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