TDMS Study 05103-05 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL
NTP Experiment-Test: 05103-05 Report: PEIRPT03
Study Type: CHRONIC Date: 05/19/95
Route: DOSED FEED Time: 19:49:13
Facility: Southern Research Institute
Chemical CAS #: 3296-90-0
Lock Date: 02/18/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05103-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:49:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.25% 0.50% 1.00%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 9 7 8
Early Deaths
Moribund Sacrifice 14 22 27 41
Natural Death 2 3 6
Survivors
Terminal Sacrifice 36 27 23 5
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (60) (60) (60)
Epithelium, Hyperplasia, Focal 1 (2%)
Intestine Large, Colon (60) (60) (60) (60)
Intussusception 1 (2%)
Parasite Metazoan 2 (3%) 1 (2%) 1 (2%) 1 (2%)
Intestine Large, Rectum (59) (60) (60) (60)
Parasite Metazoan 2 (3%) 4 (7%) 2 (3%)
Liver (60) (60) (60) (60)
Angiectasis 2 (3%) 1 (2%) 2 (3%)
Autolysis 1 (2%)
Basophilic Focus 1 (2%)
Congestion, Focal 1 (2%)
Developmental Malformation 1 (2%)
Eosinophilic Focus 1 (2%)
Fatty Change 9 (15%) 12 (20%) 11 (18%) 8 (13%)
Focal Cellular Change 42 (70%) 48 (80%) 43 (72%) 42 (70%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 3 (5%)
Hemorrhage, Focal 1 (2%)
Hepatodiaphragmatic Nodule 6 (10%) 5 (8%) 3 (5%) 9 (15%)
Hepatodiaphragmatic Nodule, Multiple 1 (2%) 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Histiocytic, Lymphoid 1 (2%)
Infiltration Cellular, Mixed Cell 4 (7%) 1 (2%) 6 (10%) 6 (10%)
Inflammation, Focal 20 (33%) 19 (32%) 19 (32%) 19 (32%)
Necrosis, Focal 1 (2%) 2 (3%) 7 (12%)
Bile Duct, Hyperplasia 26 (43%) 24 (40%) 21 (35%) 19 (32%)
Biliary Tract, Cyst 1 (2%)
Centrilobular, Atrophy 11 (18%) 10 (17%) 10 (17%) 15 (25%)
Centrilobular, Congestion 1 (2%)
Centrilobular, Degeneration 1 (2%)
Hepatocyte, Hyperplasia, Multifocal 8 (13%) 10 (17%) 7 (12%) 7 (12%)
Mesentery (6) (12) (9) (6)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05103-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:49:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.25% 0.50% 1.00%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Accessory Spleen 1 (17%)
Inflammation, Chronic 2 (33%)
Fat, Necrosis 2 (33%) 9 (75%) 7 (78%) 3 (50%)
Pancreas (60) (60) (60) (60)
Accessory Spleen 1 (2%) 1 (2%) 1 (2%)
Atrophy, Focal 24 (40%) 17 (28%) 22 (37%) 16 (27%)
Fibrosis, Focal 1 (2%)
Duct, Dilatation 1 (2%)
Pharynx (1) (1) (1) (2)
Palate, Epithelium, Hyperplasia, Focal 1 (50%)
Stomach, Forestomach (60) (60) (60) (60)
Edema 1 (2%) 1 (2%)
Erosion 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Pigmentation 1 (2%)
Ulcer 1 (2%) 1 (2%)
Ulcer, Multiple 1 (2%)
Mucosa, Hyperplasia 2 (3%) 1 (2%) 1 (2%) 1 (2%)
Stomach, Glandular (60) (60) (60) (60)
Edema 1 (2%) 1 (2%)
Erosion 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Pigmentation, Focal 1 (2%)
Tongue (1) (3) (6) (6)
Inflammation, Chronic, Focal 1 (17%)
Epithelium, Hyperplasia, Focal 1 (33%) 1 (17%) 1 (17%)
Tooth (2)
Developmental Malformation 1 (50%)
Incisor, Dysplasia 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (60) (60) (60)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Accessory Adrenal Cortical Nodule 5 (8%) 4 (7%) 4 (7%) 3 (5%)
Angiectasis 1 (2%) 1 (2%) 3 (5%) 1 (2%)
Congestion 3 (5%) 2 (3%)
Focal Cellular Change 11 (18%) 16 (27%) 8 (13%) 11 (18%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Histiocytic 2 (3%)
Hyperplasia, Lymphoid 2 (3%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05103-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:49:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.25% 0.50% 1.00%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Adrenal Medulla (60) (60) (60) (60)
Hyperplasia 2 (3%) 1 (2%) 4 (7%) 2 (3%)
Parathyroid Gland (57) (59) (59) (60)
Cyst 1 (2%)
Hyperplasia 2 (3%)
Pituitary Gland (58) (60) (59) (59)
Angiectasis 18 (31%) 10 (17%) 9 (15%) 9 (15%)
Cyst 7 (12%) 12 (20%) 12 (20%) 12 (20%)
Hemorrhage 1 (2%)
Pars Distalis, Angiectasis 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Focal Cellular Change 8 (14%) 5 (8%) 7 (12%) 2 (3%)
Pars Distalis, Hyperplasia 1 (2%)
Pars Distalis, Hyperplasia, Focal 9 (16%) 4 (7%) 1 (2%) 6 (10%)
Pars Distalis, Pigmentation 1 (2%)
Thyroid Gland (60) (60) (60) (60)
Ultimobranchial Cyst 1 (2%) 1 (2%) 4 (7%)
C-Cell, Hyperplasia 8 (13%) 14 (23%) 18 (30%) 14 (23%)
Follicle, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (58) (58) (56) (60)
Degeneration, Cystic 48 (83%) 50 (86%) 46 (82%) 56 (93%)
Dilatation 1 (2%)
Hyperplasia 4 (7%) 4 (7%) 4 (7%) 1 (2%)
Inflammation, Chronic 2 (3%) 2 (3%) 2 (4%) 1 (2%)
Ovary (60) (60) (60) (60)
Angiectasis 1 (2%)
Cyst 7 (12%) 4 (7%) 5 (8%) 7 (12%)
Bilateral, Cyst 1 (2%)
Corpus Luteum, Hyperplasia, Lymphoid 2 (3%) 3 (5%) 1 (2%)
Corpus Luteum, Thecal Cell, Hyperplasia 2 (3%) 3 (5%) 1 (2%)
Uterus (60) (60) (60) (60)
Hydrometra 2 (3%) 2 (3%) 4 (7%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Cervix, Hyperplasia 1 (2%)
Endometrium, Cyst 1 (2%) 2 (3%) 4 (7%) 2 (3%)
Endometrium, Hyperplasia, Cystic 4 (7%) 2 (3%) 2 (3%) 7 (12%)
Endometrium, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05103-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:49:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.25% 0.50% 1.00%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Hypercellularity 5 (8%) 4 (7%) 11 (18%) 10 (17%)
Hyperplasia, Focal, Histiocytic 1 (2%)
Metaplasia, Osseous 1 (2%)
Myelofibrosis 1 (2%) 1 (2%)
Lymph Node (16) (11) (15) (19)
Axillary, Hyperplasia 1 (5%)
Deep Cervical, Hyperplasia 1 (7%)
Iliac, Inflammation, Suppurative 1 (5%)
Inguinal, Hyperplasia 1 (6%) 1 (5%)
Mediastinal, Hemorrhage 6 (38%) 3 (27%) 1 (7%) 2 (11%)
Mediastinal, Hyperplasia 1 (7%)
Mediastinal, Pigmentation 1 (9%) 1 (5%)
Pancreatic, Hemorrhage 1 (7%)
Renal, Hyperplasia 1 (5%)
Renal, Pigmentation 1 (5%)
Lymph Node, Mandibular (59) (57) (60) (58)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Lymph Node, Mesenteric (60) (60) (60) (60)
Hemorrhage 2 (3%) 2 (3%) 2 (3%) 2 (3%)
Hyperplasia 1 (2%)
Spleen (60) (60) (60) (60)
Angiectasis 1 (2%)
Congestion 2 (3%)
Fibrosis, Focal 1 (2%) 4 (7%) 5 (8%)
Hematopoietic Cell Proliferation 1 (2%) 2 (3%) 7 (12%) 10 (17%)
Necrosis, Focal 1 (2%)
Thymus (59) (59) (58) (60)
Congestion 1 (2%)
Cyst 2 (3%) 2 (3%)
Hemorrhage 2 (3%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (60) (60) (60)
Dilatation 44 (73%) 45 (75%) 37 (62%) 34 (57%)
Hyperplasia 7 (12%) 12 (20%) 8 (13%) 10 (17%)
Inflammation, Chronic 1 (2%)
Skin (60) (60) (60) (60)
Alopecia 1 (2%)
Hyperkeratosis, Focal 1 (2%)
Epidermis, Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05103-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:49:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.25% 0.50% 1.00%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Subcutaneous Tissue, Inflammation, Chronic,
Focal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Hyperostosis 10 (17%) 10 (17%) 10 (17%) 4 (7%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (60) (60) (60)
Compression 9 (15%) 10 (17%) 9 (15%) 4 (7%)
Hemorrhage 1 (2%) 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Congestion 1 (2%) 1 (2%) 1 (2%)
Fibrosis, Focal 1 (2%)
Hemorrhage, Diffuse 1 (2%)
Hyperplasia, Focal, Macrophage 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 2 (3%) 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (3%) 4 (7%) 4 (7%)
Pleura, Inflammation, Chronic, Focal 1 (2%)
Nose (59) (60) (60) (60)
Fungus 1 (2%) 3 (5%) 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (3%) 4 (7%) 2 (3%)
Mucosa, Hyperplasia, Focal 1 (2%)
Nasolacrimal Duct, Cyst 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (1) (3)
Atrophy 2 (67%) 1 (33%)
Cataract 3 (100%) 1 (100%) 1 (33%)
Fibrosis 1 (33%)
Hemorrhage 1 (33%)
Inflammation, Chronic 1 (33%)
Necrosis, Focal 1 (33%)
Synechia 1 (33%)
Retina, Degeneration 2 (67%) 1 (100%) 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05103-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:49:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.25% 0.50% 1.00%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Atrophy, Focal 2 (3%) 1 (2%) 7 (12%)
Cyst 1 (2%) 1 (2%)
Inflammation, Chronic, Suppurative 1 (2%)
Nephropathy 56 (93%) 57 (95%) 56 (93%) 57 (95%)
Papilla, Degeneration 1 (2%) 3 (5%) 17 (28%)
Papilla, Epithelium, Hyperplasia 1 (2%) 1 (2%) 7 (12%)
Pelvis, Dilatation 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%)
Renal Tubule, Epithelium, Hyperplasia, Focal 1 (2%)
Urinary Bladder (60) (60) (60) (60)
Dilatation 1 (2%)
Inflammation, Chronic 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05103-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:49:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.25% 0.50% 1.00% 2.00%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 60 60 60 70
Scheduled Sacrifice 19 7 9 5 10
Early Deaths
Moribund Sacrifice 24 30 36 43 55
Natural Death 1 3 2 11 5
Survivors
Terminal Sacrifice 26 20 13 1
Animals Examined Microscopically 70 60 60 60 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (70) (60) (60) (60) (70)
Epithelium, Hyperplasia, Focal 1 (2%)
Intestine Large, Colon (70) (59) (60) (59) (69)
Parasite Metazoan 2 (3%) 3 (5%) 2 (3%)
Thrombosis 1 (2%)
Intestine Large, Rectum (70) (59) (59) (58) (69)
Parasite Metazoan 2 (3%) 4 (7%) 5 (8%) 8 (14%) 2 (3%)
Intestine Large, Cecum (70) (59) (60) (59) (69)
Inflammation, Chronic 1 (1%)
Parasite Metazoan 1 (2%) 1 (1%)
Ulcer 1 (1%)
Intestine Small, Jejunum (70) (59) (60) (58) (69)
Diverticulum 2 (3%)
Inflammation, Chronic, Focal 1 (1%)
Metaplasia, Focal, Osseous 1 (1%)
Mucosa, Hyperplasia 1 (2%)
Mucosa, Hyperplasia, Cystic 1 (1%)
Intestine Small, Ileum (70) (59) (60) (58) (69)
Inflammation, Chronic, Focal 1 (1%) 2 (3%)
Ulcer 1 (1%)
Liver (70) (60) (60) (60) (70)
Angiectasis 1 (1%) 2 (3%) 1 (2%) 3 (5%) 3 (4%)
Basophilic Focus 32 (46%) 16 (27%) 16 (27%) 10 (17%) 12 (17%)
Clear Cell Focus 3 (4%) 4 (7%) 1 (2%) 1 (2%)
Congestion, Focal 1 (2%) 1 (1%)
Cyst 2 (3%)
Degeneration, Cystic 9 (13%) 6 (10%) 11 (18%) 5 (8%) 7 (10%)
Developmental Malformation 1 (1%)
Eosinophilic Focus 3 (4%) 6 (10%) 2 (3%) 2 (3%) 5 (7%)
Fatty Change 27 (39%) 25 (42%) 16 (27%) 15 (25%) 19 (27%)
Fibrosis, Focal 2 (3%)
Focal Cellular Change 1 (2%) 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05103-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:49:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.25% 0.50% 1.00% 2.00%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hematopoietic Cell Proliferation 1 (1%) 1 (2%) 1 (2%) 3 (5%) 4 (6%)
Hepatodiaphragmatic Nodule 5 (7%) 2 (3%) 4 (7%) 4 (7%) 5 (7%)
Hepatodiaphragmatic Nodule, Multiple 1 (1%) 1 (2%) 1 (1%)
Hyperplasia, Focal, Histiocytic, Lymphoid 1 (1%)
Infarct 1 (2%)
Infiltration Cellular, Mixed Cell 10 (14%) 5 (8%) 7 (12%) 8 (13%) 13 (19%)
Inflammation, Focal 10 (14%) 8 (13%) 6 (10%) 4 (7%) 10 (14%)
Mixed Cell Focus 1 (1%) 1 (2%) 1 (2%) 1 (2%) 1 (1%)
Necrosis, Focal 7 (10%) 1 (2%) 2 (3%) 4 (7%) 2 (3%)
Pigmentation 1 (2%)
Thrombosis 1 (1%) 1 (2%) 1 (2%)
Bile Duct, Dilatation, Focal 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 55 (79%) 50 (83%) 51 (85%) 43 (72%) 44 (63%)
Biliary Tract, Cyst 1 (1%)
Centrilobular, Atrophy 20 (29%) 23 (38%) 31 (52%) 26 (43%) 28 (40%)
Centrilobular, Congestion 1 (2%) 1 (1%)
Centrilobular, Hemorrhage 1 (1%)
Centrilobular, Necrosis 1 (2%) 1 (2%) 4 (7%) 1 (1%)
Hepatocyte, Hyperplasia, Multifocal 3 (4%) 9 (15%) 10 (17%) 8 (13%) 4 (6%)
Mesentery (16) (20) (21) (23) (30)
Accessory Spleen 1 (5%)
Inflammation, Chronic 1 (6%) 1 (5%) 1 (5%) 2 (9%) 2 (7%)
Fat, Necrosis 9 (56%) 9 (45%) 6 (29%) 5 (22%) 7 (23%)
Pancreas (70) (60) (60) (58) (69)
Accessory Spleen 1 (1%)
Atrophy, Diffuse 1 (1%)
Atrophy, Focal 33 (47%) 23 (38%) 27 (45%) 26 (45%) 22 (32%)
Autolysis 1 (2%)
Hyperplasia, Focal 1 (1%) 1 (2%) 1 (2%)
Acinar Cell, Focal Cellular Change 1 (1%)
Acinar Cell, Hyperplasia, Focal 3 (4%) 9 (15%) 12 (20%) 14 (24%) 27 (39%)
Duct, Dilatation 1 (1%) 1 (2%) 2 (3%) 2 (3%)
Pharynx (1) (3) (4) (5) (10)
Palate, Epithelium, Hyperplasia, Focal 1 (100%) 1 (33%) 1 (25%) 3 (60%) 2 (20%)
Salivary Glands (70) (59) (58) (60) (70)
Cyst 1 (1%)
Inflammation, Chronic 1 (2%)
Stomach, Forestomach (70) (60) (60) (60) (69)
Edema 1 (1%) 1 (2%) 1 (2%)
Erosion 3 (5%) 1 (1%)
Hyperplasia 1 (2%)
Inflammation, Chronic 3 (4%) 9 (15%) 4 (7%) 3 (5%) 3 (4%)
Pigmentation 1 (2%)
Ulcer 1 (1%) 5 (8%) 4 (7%) 2 (3%) 2 (3%)
Mucosa, Cyst 1 (2%)
Mucosa, Hyperplasia 4 (6%) 12 (20%) 6 (10%) 6 (10%) 6 (9%)
Stomach, Glandular (70) (60) (60) (58) (70)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05103-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:49:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.25% 0.50% 1.00% 2.00%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Edema 1 (1%) 1 (2%)
Erosion 1 (1%) 1 (2%) 4 (7%) 4 (6%)
Inflammation, Chronic 2 (3%) 2 (3%)
Pigmentation, Focal 1 (1%) 1 (2%) 2 (3%)
Mucosa, Hyperplasia 1 (1%) 2 (3%)
Tongue (2) (5) (13) (9)
Epithelium, Hyperplasia, Focal 4 (31%) 3 (33%)
Tooth (1) (1) (2)
Incisor, Dysplasia 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (3) (1) (2) (2)
Mesenteric Artery, Inflammation, Chronic 2 (100%)
Heart (69) (60) (60) (60) (70)
Inflammation, Chronic, Focal 1 (2%)
Mineralization, Focal 1 (2%)
Thrombosis 1 (1%) 1 (2%) 2 (3%) 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (70) (60) (60) (59) (70)
Accessory Adrenal Cortical Nodule 7 (10%) 4 (7%) 4 (7%) 4 (7%) 11 (16%)
Angiectasis 1 (2%) 1 (1%)
Atrophy 1 (2%)
Congestion 3 (4%) 1 (2%) 2 (3%) 1 (1%)
Focal Cellular Change 7 (10%) 6 (10%) 6 (10%) 14 (24%) 6 (9%)
Hematopoietic Cell Proliferation 1 (2%) 1 (1%)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%)
Necrosis, Focal 2 (3%) 1 (1%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%) 1 (1%)
Adrenal Medulla (70) (60) (60) (59) (70)
Angiectasis 1 (1%)
Hyperplasia 10 (14%) 15 (25%) 13 (22%) 5 (8%) 9 (13%)
Islets, Pancreatic (70) (60) (60) (60) (69)
Hyperplasia 1 (1%) 1 (1%)
Parathyroid Gland (68) (57) (58) (58) (68)
Hyperplasia 4 (6%) 1 (2%) 1 (2%) 1 (1%)
Pituitary Gland (69) (58) (59) (58) (67)
Angiectasis 2 (3%) 2 (3%) 3 (5%)
Cyst 3 (4%) 2 (3%) 1 (2%) 2 (3%) 6 (9%)
Hemorrhage 1 (2%)
Pars Distalis, Focal Cellular Change 7 (10%) 3 (5%) 4 (7%) 5 (9%) 6 (9%)
Pars Distalis, Hyperplasia, Focal 5 (7%) 6 (10%) 1 (2%) 2 (3%) 5 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05103-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:49:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.25% 0.50% 1.00% 2.00%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thyroid Gland (70) (60) (60) (60) (69)
Ultimobranchial Cyst 3 (4%) 1 (2%) 3 (5%)
C-Cell, Hyperplasia 8 (11%) 11 (18%) 5 (8%) 5 (8%) 15 (22%)
Follicle, Dilatation 1 (2%) 3 (5%) 9 (13%)
Follicular Cell, Hyperplasia 3 (4%) 2 (3%) 5 (8%) 6 (9%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (2) (3) (6) (8)
Scrotal, Inflammation, Chronic 1 (17%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (2) (3)
Hyperplasia 1 (100%) 2 (100%) 3 (100%)
Epididymis (70) (60) (60) (59) (70)
Granuloma Sperm 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Preputial Gland (70) (59) (60) (60) (70)
Degeneration, Cystic 67 (96%) 59 (100%) 57 (95%) 60 (100%) 64 (91%)
Hyperplasia 2 (3%) 3 (5%) 2 (3%)
Inflammation, Chronic 5 (7%) 3 (5%) 3 (5%) 3 (5%) 8 (11%)
Prostate (70) (60) (60) (60) (70)
Inflammation, Suppurative 33 (47%) 41 (68%) 34 (57%) 40 (67%) 36 (51%)
Epithelium, Hyperplasia, Focal 3 (4%) 3 (5%) 1 (2%)
Seminal Vesicle (70) (60) (60) (60) (70)
Dilatation 1 (2%) 1 (1%)
Edema 1 (1%)
Hyperplasia 1 (1%) 8 (13%) 9 (15%) 17 (28%) 33 (47%)
Inflammation, Chronic 2 (3%)
Testes (70) (60) (60) (60) (70)
Mineralization, Focal 1 (2%)
Germinal Epithelium, Degeneration 7 (10%) 7 (12%) 7 (12%) 6 (10%) 4 (6%)
Interstitial Cell, Hyperplasia 2 (3%) 4 (7%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (60) (60) (60) (70)
Hypercellularity 7 (10%) 7 (12%) 6 (10%) 16 (27%) 18 (26%)
Hyperplasia, Focal, Histiocytic 1 (1%)
Metaplasia, Osseous 4 (7%)
Myelofibrosis 2 (3%) 1 (2%) 3 (5%) 2 (3%)
Necrosis, Focal 1 (1%)
Lymph Node (25) (23) (36) (27) (31)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05103-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:49:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.25% 0.50% 1.00% 2.00%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Deep Cervical, Hyperplasia 1 (3%)
Iliac, Hyperplasia 1 (4%)
Inguinal, Hyperplasia 2 (8%) 1 (4%)
Inguinal, Hyperplasia, Lymphoid 1 (4%)
Mediastinal, Edema 2 (6%)
Mediastinal, Hemorrhage 2 (8%) 3 (13%) 1 (3%) 3 (11%) 4 (13%)
Mediastinal, Hyperplasia 1 (4%) 2 (7%) 2 (6%)
Mediastinal, Hyperplasia, Lymphoid 1 (3%) 1 (3%)
Mediastinal, Pigmentation 1 (4%) 3 (10%)
Mediastinal, Thrombosis 1 (3%)
Pancreatic, Edema 1 (4%)
Pancreatic, Hemorrhage 1 (4%) 1 (4%)
Pancreatic, Hyperplasia, Macrophage 1 (4%)
Lymph Node, Mandibular (68) (59) (58) (60) (69)
Congestion 1 (2%) 1 (2%)
Edema 1 (1%) 1 (2%) 1 (2%) 1 (2%) 1 (1%)
Hemorrhage 1 (1%) 1 (2%)
Hyperplasia 4 (6%) 2 (3%) 2 (3%) 3 (5%) 10 (14%)
Pigmentation 1 (2%)
Lymph Node, Mesenteric (69) (60) (60) (60) (70)
Edema 1 (2%) 4 (7%) 3 (4%)
Hemorrhage 2 (3%)
Hyperplasia 1 (1%) 1 (2%) 4 (7%) 2 (3%)
Hyperplasia, Lymphoid 1 (1%) 1 (2%)
Spleen (70) (60) (60) (59) (70)
Autolysis 1 (2%)
Congestion 1 (2%)
Developmental Malformation 1 (1%) 2 (3%) 1 (2%)
Fibrosis, Focal 16 (23%) 11 (18%) 22 (37%) 24 (41%) 28 (40%)
Hematopoietic Cell Proliferation 1 (1%) 3 (5%) 3 (5%) 8 (14%) 17 (24%)
Necrosis, Focal 1 (1%) 2 (3%) 1 (1%)
Pigmentation 1 (2%)
Thymus (67) (60) (58) (57) (67)
Congestion 1 (2%)
Cyst 1 (1%)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (66) (58) (57) (53) (60)
Angiectasis 1 (2%)
Dilatation 11 (17%) 9 (16%) 11 (19%) 4 (8%) 4 (7%)
Hemorrhage 1 (2%)
Hyperplasia 3 (5%) 2 (3%) 3 (5%) 1 (2%) 2 (3%)
Inflammation, Chronic 1 (2%)
Skin (70) (60) (60) (59) (69)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05103-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:49:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.25% 0.50% 1.00% 2.00%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Cyst Epithelial Inclusion 1 (2%) 1 (2%) 2 (3%)
Hemorrhage, Focal 1 (2%)
Hyperkeratosis, Focal 1 (1%) 1 (2%) 3 (5%) 2 (3%) 2 (3%)
Inflammation, Chronic, Focal 1 (2%) 1 (2%) 3 (5%) 3 (4%)
Ulcer 1 (2%)
Epidermis, Hyperplasia, Focal 1 (1%) 2 (3%) 2 (3%) 2 (3%) 3 (4%)
Hair Follicle, Cyst 1 (1%)
Prepuce, Inflammation, Chronic 1 (2%)
Sebaceous Gland, Cyst 1 (2%)
Sebaceous Gland, Hyperplasia, Focal 1 (2%) 1 (1%)
Subcutaneous Tissue, Fibrosis 1 (1%) 1 (2%) 1 (1%)
Subcutaneous Tissue, Inflammation, Chronic,
Focal 1 (2%) 2 (3%)
Subcutaneous Tissue, Fat, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (60) (60) (60) (70)
Hyperostosis 6 (9%) 7 (12%) 4 (7%) 5 (8%) 11 (16%)
Adventitia, Calvarium, Proliferation
Connective Tissue 1 (1%)
Skeletal Muscle (3) (2) (4) (4)
Hemorrhage, Focal 1 (25%)
Inflammation, Chronic 1 (25%)
Necrosis, Focal 1 (25%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (60) (60) (60) (70)
Compression 3 (4%) 7 (12%) 2 (3%) 3 (5%) 3 (4%)
Hemorrhage 3 (4%) 3 (5%) 2 (3%) 2 (3%) 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (60) (60) (60) (70)
Congestion 1 (1%) 3 (5%) 2 (3%)
Hemorrhage, Focal 1 (2%) 2 (3%) 1 (2%) 1 (1%)
Hyperplasia, Diffuse, Histiocytic 1 (2%)
Hyperplasia, Focal, Histiocytic 1 (2%)
Inflammation, Chronic, Focal 2 (3%) 1 (2%) 1 (1%)
Metaplasia, Osseous 1 (1%) 1 (1%)
Alveolar Epithelium, Hyperplasia 3 (4%) 4 (7%) 5 (8%) 7 (12%) 14 (20%)
Peribronchial, Infiltration Cellular,
Lymphocyte 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05103-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:49:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.25% 0.50% 1.00% 2.00%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nose (70) (60) (60) (60) (70)
Fungus 7 (10%) 3 (5%) 6 (10%) 5 (8%) 5 (7%)
Inflammation, Suppurative 12 (17%) 8 (13%) 17 (28%) 11 (18%) 11 (16%)
Mucosa, Angiectasis, Focal 1 (2%)
Mucosa, Hyperkeratosis, Focal 1 (2%)
Mucosa, Hyperplasia, Focal 2 (3%)
Mucosa, Metaplasia, Focal, Squamous 2 (3%)
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (1%)
Respiratory Epithelium, Hyperplasia, Focal 1 (1%)
Trachea (70) (60) (60) (60) (70)
Glands, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (3) (1)
Atrophy 1 (100%) 1 (33%)
Cataract 1 (50%) 2 (67%)
Fibrosis 1 (100%)
Inflammation, Chronic 1 (50%)
Synechia 1 (50%) 1 (33%)
Cornea, Inflammation, Chronic 1 (33%)
Retina, Degeneration 1 (100%) 1 (33%)
Sclera, Mineralization, Focal 1 (100%)
Zymbal's Gland (2) (1) (5) (5) (15)
Dilatation 1 (20%) 1 (7%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (60) (60) (60) (69)
Atrophy, Focal 6 (10%)
Cyst 2 (3%) 1 (2%) 1 (1%)
Hydronephrosis 1 (1%)
Infarct 1 (1%)
Inflammation, Chronic, Suppurative 1 (2%) 1 (2%)
Nephropathy 70 (100%) 60 (100%) 60 (100%) 58 (97%) 61 (88%)
Cortex, Medulla, Mineralization, Focal 1 (2%)
Papilla, Degeneration 5 (8%) 32 (53%) 33 (55%) 24 (35%)
Papilla, Mineralization, Focal 2 (3%)
Papilla, Epithelium, Hyperplasia 11 (16%) 20 (33%) 26 (43%) 52 (87%) 21 (30%)
Pelvis, Dilatation 1 (2%) 1 (2%) 1 (1%)
Pelvis, Transitional Epithelium, Hyperplasia 4 (7%) 4 (6%)
Renal Tubule, Epithelium, Hyperplasia, Focal 2 (3%)
Urethra (1) (1) (1) (1)
Bulbourethral Gland, Dilatation 1 (100%) 1 (100%) 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05103-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 05/19/95
Route: DOSED FEED Time: 19:49:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.25% 0.50% 1.00% 2.00%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Urinary Bladder (70) (60) (60) (60) (69)
Dilatation 1 (2%)
Hemorrhage 1 (1%)
Inflammation, Chronic 1 (1%) 1 (2%) 2 (3%)
Transitional Epithelium, Hyperplasia 1 (2%) 3 (5%) 20 (29%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
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