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https://ntp.niehs.nih.gov/go/1789

TDMS Study 05103-05 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL


NTP Experiment-Test: 05103-05                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DOSED FEED                                                                                                 Time: 19:49:13




       Facility:  Southern Research Institute

       Chemical CAS #:  3296-90-0

       Lock Date:  02/18/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05103-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.25%        0.50%        1.00%                                     
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            9            7            8                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           22           27           41                                     
    Natural Death                                                   2            3            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           27           23            5                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)                                   
      Epithelium, Hyperplasia, Focal                                                          1 (2%)                                
   Intestine Large, Colon                             (60)         (60)         (60)         (60)                                   
      Intussusception                                               1 (2%)                                                          
      Parasite Metazoan                                2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
   Intestine Large, Rectum                            (59)         (60)         (60)         (60)                                   
      Parasite Metazoan                                2 (3%)       4 (7%)                    2 (3%)                                
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                      2 (3%)                    1 (2%)       2 (3%)                                
      Autolysis                                                                               1 (2%)                                
      Basophilic Focus                                 1 (2%)                                                                       
      Congestion, Focal                                                          1 (2%)                                             
      Developmental Malformation                                    1 (2%)                                                          
      Eosinophilic Focus                               1 (2%)                                                                       
      Fatty Change                                     9 (15%)     12 (20%)     11 (18%)      8 (13%)                               
      Focal Cellular Change                           42 (70%)     48 (80%)     43 (72%)     42 (70%)                               
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                    3 (5%)                                
      Hemorrhage, Focal                                                          1 (2%)                                             
      Hepatodiaphragmatic Nodule                       6 (10%)      5 (8%)       3 (5%)       9 (15%)                               
      Hepatodiaphragmatic Nodule, Multiple                                       1 (2%)       1 (2%)                                
      Hyperplasia, Histiocytic                                                   1 (2%)                                             
      Hyperplasia, Histiocytic, Lymphoid                                         1 (2%)                                             
      Infiltration Cellular, Mixed Cell                4 (7%)       1 (2%)       6 (10%)      6 (10%)                               
      Inflammation, Focal                             20 (33%)     19 (32%)     19 (32%)     19 (32%)                               
      Necrosis, Focal                                  1 (2%)                    2 (3%)       7 (12%)                               
      Bile Duct, Hyperplasia                          26 (43%)     24 (40%)     21 (35%)     19 (32%)                               
      Biliary Tract, Cyst                                           1 (2%)                                                          
      Centrilobular, Atrophy                          11 (18%)     10 (17%)     10 (17%)     15 (25%)                               
      Centrilobular, Congestion                                                  1 (2%)                                             
      Centrilobular, Degeneration                                                             1 (2%)                                
      Hepatocyte, Hyperplasia, Multifocal              8 (13%)     10 (17%)      7 (12%)      7 (12%)                               
   Mesentery                                          (6)          (12)         (9)          (6)                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05103-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.25%        0.50%        1.00%                                     
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Accessory Spleen                                 1 (17%)                                                                      
      Inflammation, Chronic                                                                   2 (33%)                               
      Fat, Necrosis                                    2 (33%)      9 (75%)      7 (78%)      3 (50%)                               
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Accessory Spleen                                 1 (2%)       1 (2%)       1 (2%)                                             
      Atrophy, Focal                                  24 (40%)     17 (28%)     22 (37%)     16 (27%)                               
      Fibrosis, Focal                                  1 (2%)                                                                       
      Duct, Dilatation                                              1 (2%)                                                          
   Pharynx                                            (1)          (1)          (1)          (2)                                    
      Palate, Epithelium, Hyperplasia, Focal                                                  1 (50%)                               
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Edema                                            1 (2%)       1 (2%)                                                          
      Erosion                                                                                 1 (2%)                                
      Inflammation, Chronic                            1 (2%)       1 (2%)                    1 (2%)                                
      Pigmentation                                                                            1 (2%)                                
      Ulcer                                                         1 (2%)                    1 (2%)                                
      Ulcer, Multiple                                  1 (2%)                                                                       
      Mucosa, Hyperplasia                              2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Edema                                            1 (2%)       1 (2%)                                                          
      Erosion                                          1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Pigmentation, Focal                                           1 (2%)                                                          
   Tongue                                             (1)          (3)          (6)          (6)                                    
      Inflammation, Chronic, Focal                                                            1 (17%)                               
      Epithelium, Hyperplasia, Focal                                1 (33%)      1 (17%)      1 (17%)                               
   Tooth                                                                        (2)                                                 
      Developmental Malformation                                                 1 (50%)                                            
      Incisor, Dysplasia                                                         1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (60)         (60)         (60)                                   
      Thrombosis                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule                5 (8%)       4 (7%)       4 (7%)       3 (5%)                                
      Angiectasis                                      1 (2%)       1 (2%)       3 (5%)       1 (2%)                                
      Congestion                                                                 3 (5%)       2 (3%)                                
      Focal Cellular Change                           11 (18%)     16 (27%)      8 (13%)     11 (18%)                               
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hyperplasia, Histiocytic                         2 (3%)                                                                       
      Hyperplasia, Lymphoid                            2 (3%)                                                                       
      Vacuolization Cytoplasmic                        1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05103-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.25%        0.50%        1.00%                                     
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Hyperplasia                                      2 (3%)       1 (2%)       4 (7%)       2 (3%)                                
   Parathyroid Gland                                  (57)         (59)         (59)         (60)                                   
      Cyst                                                          1 (2%)                                                          
      Hyperplasia                                                                2 (3%)                                             
   Pituitary Gland                                    (58)         (60)         (59)         (59)                                   
      Angiectasis                                     18 (31%)     10 (17%)      9 (15%)      9 (15%)                               
      Cyst                                             7 (12%)     12 (20%)     12 (20%)     12 (20%)                               
      Hemorrhage                                                                 1 (2%)                                             
      Pars Distalis, Angiectasis                       1 (2%)       1 (2%)                    1 (2%)                                
      Pars Distalis, Cyst                                           1 (2%)                                                          
      Pars Distalis, Focal Cellular Change             8 (14%)      5 (8%)       7 (12%)      2 (3%)                                
      Pars Distalis, Hyperplasia                                                 1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                9 (16%)      4 (7%)       1 (2%)       6 (10%)                               
      Pars Distalis, Pigmentation                                   1 (2%)                                                          
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Ultimobranchial Cyst                             1 (2%)                    1 (2%)       4 (7%)                                
      C-Cell, Hyperplasia                              8 (13%)     14 (23%)     18 (30%)     14 (23%)                               
      Follicle, Dilatation                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (58)         (58)         (56)         (60)                                   
      Degeneration, Cystic                            48 (83%)     50 (86%)     46 (82%)     56 (93%)                               
      Dilatation                                                                 1 (2%)                                             
      Hyperplasia                                      4 (7%)       4 (7%)       4 (7%)       1 (2%)                                
      Inflammation, Chronic                            2 (3%)       2 (3%)       2 (4%)       1 (2%)                                
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                             7 (12%)      4 (7%)       5 (8%)       7 (12%)                               
      Bilateral, Cyst                                               1 (2%)                                                          
      Corpus Luteum, Hyperplasia, Lymphoid             2 (3%)                    3 (5%)       1 (2%)                                
      Corpus Luteum, Thecal Cell, Hyperplasia          2 (3%)                    3 (5%)       1 (2%)                                
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Hydrometra                                       2 (3%)       2 (3%)                    4 (7%)                                
      Inflammation, Suppurative                        1 (2%)       1 (2%)                    1 (2%)                                
      Cervix, Hyperplasia                                                                     1 (2%)                                
      Endometrium, Cyst                                1 (2%)       2 (3%)       4 (7%)       2 (3%)                                
      Endometrium, Hyperplasia, Cystic                 4 (7%)       2 (3%)       2 (3%)       7 (12%)                               
      Endometrium, Inflammation                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05103-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.25%        0.50%        1.00%                                     
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hypercellularity                                 5 (8%)       4 (7%)      11 (18%)     10 (17%)                               
      Hyperplasia, Focal, Histiocytic                                                         1 (2%)                                
      Metaplasia, Osseous                                           1 (2%)                                                          
      Myelofibrosis                                    1 (2%)       1 (2%)                                                          
   Lymph Node                                         (16)         (11)         (15)         (19)                                   
      Axillary, Hyperplasia                                                                   1 (5%)                                
      Deep Cervical, Hyperplasia                                                 1 (7%)                                             
      Iliac, Inflammation, Suppurative                                                        1 (5%)                                
      Inguinal, Hyperplasia                            1 (6%)                                 1 (5%)                                
      Mediastinal, Hemorrhage                          6 (38%)      3 (27%)      1 (7%)       2 (11%)                               
      Mediastinal, Hyperplasia                                                   1 (7%)                                             
      Mediastinal, Pigmentation                                     1 (9%)                    1 (5%)                                
      Pancreatic, Hemorrhage                                                     1 (7%)                                             
      Renal, Hyperplasia                                                                      1 (5%)                                
      Renal, Pigmentation                                                                     1 (5%)                                
   Lymph Node, Mandibular                             (59)         (57)         (60)         (58)                                   
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (60)                                   
      Hemorrhage                                       2 (3%)       2 (3%)       2 (3%)       2 (3%)                                
      Hyperplasia                                                                1 (2%)                                             
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                                    2 (3%)                                                          
      Fibrosis, Focal                                  1 (2%)                    4 (7%)       5 (8%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       2 (3%)       7 (12%)     10 (17%)                               
      Necrosis, Focal                                  1 (2%)                                                                       
   Thymus                                             (59)         (59)         (58)         (60)                                   
      Congestion                                                                 1 (2%)                                             
      Cyst                                             2 (3%)       2 (3%)                                                          
      Hemorrhage                                                                 2 (3%)                                             
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (60)                                   
      Dilatation                                      44 (73%)     45 (75%)     37 (62%)     34 (57%)                               
      Hyperplasia                                      7 (12%)     12 (20%)      8 (13%)     10 (17%)                               
      Inflammation, Chronic                                         1 (2%)                                                          
   Skin                                               (60)         (60)         (60)         (60)                                   
      Alopecia                                                      1 (2%)                                                          
      Hyperkeratosis, Focal                            1 (2%)                                                                       
      Epidermis, Hyperplasia, Focal                    1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05103-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.25%        0.50%        1.00%                                     
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
           Focal                                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Hyperostosis                                    10 (17%)     10 (17%)     10 (17%)      4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (60)         (60)         (60)                                   
      Compression                                      9 (15%)     10 (17%)      9 (15%)      4 (7%)                                
      Hemorrhage                                       1 (2%)                    2 (3%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                                    1 (2%)       1 (2%)       1 (2%)                                
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hemorrhage, Diffuse                                                                     1 (2%)                                
      Hyperplasia, Focal, Macrophage                   1 (2%)                                                                       
      Inflammation, Chronic, Focal                                  1 (2%)       2 (3%)       1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 2 (3%)                    4 (7%)       4 (7%)                                
      Pleura, Inflammation, Chronic, Focal                          1 (2%)                                                          
   Nose                                               (59)         (60)         (60)         (60)                                   
      Fungus                                                        1 (2%)       3 (5%)       1 (2%)                                
      Inflammation, Suppurative                        1 (2%)       2 (3%)       4 (7%)       2 (3%)                                
      Mucosa, Hyperplasia, Focal                                                              1 (2%)                                
      Nasolacrimal Duct, Cyst                                                    1 (2%)       1 (2%)                                
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (1)          (3)                                                 
      Atrophy                                          2 (67%)                   1 (33%)                                            
      Cataract                                         3 (100%)     1 (100%)     1 (33%)                                            
      Fibrosis                                         1 (33%)                                                                      
      Hemorrhage                                                                 1 (33%)                                            
      Inflammation, Chronic                                                      1 (33%)                                            
      Necrosis, Focal                                                            1 (33%)                                            
      Synechia                                         1 (33%)                                                                      
      Retina, Degeneration                             2 (67%)      1 (100%)     1 (33%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05103-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.25%        0.50%        1.00%                                     
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Atrophy, Focal                                                2 (3%)       1 (2%)       7 (12%)                               
      Cyst                                             1 (2%)                                 1 (2%)                                
      Inflammation, Chronic, Suppurative               1 (2%)                                                                       
      Nephropathy                                     56 (93%)     57 (95%)     56 (93%)     57 (95%)                               
      Papilla, Degeneration                                         1 (2%)       3 (5%)      17 (28%)                               
      Papilla, Epithelium, Hyperplasia                              1 (2%)       1 (2%)       7 (12%)                               
      Pelvis, Dilatation                                                                      1 (2%)                                
      Pelvis, Transitional Epithelium, Hyperplasia                  1 (2%)                                                          
      Renal Tubule, Epithelium, Hyperplasia, Focal                  1 (2%)                                                          
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Dilatation                                                                              1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05103-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.25%        0.50%        1.00%        2.00%                        
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           60           60           60           70                        
  Scheduled Sacrifice                                 19            7            9            5           10                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                24           30           36           43           55                        
    Natural Death                                      1            3            2           11            5                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           20           13            1                                     
  Animals Examined Microscopically                    70           60           60           60           70                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (70)         (60)         (60)         (60)         (70)                      
      Epithelium, Hyperplasia, Focal                                                          1 (2%)                                
   Intestine Large, Colon                             (70)         (59)         (60)         (59)         (69)                      
      Parasite Metazoan                                2 (3%)                    3 (5%)                    2 (3%)                   
      Thrombosis                                                                              1 (2%)                                
   Intestine Large, Rectum                            (70)         (59)         (59)         (58)         (69)                      
      Parasite Metazoan                                2 (3%)       4 (7%)       5 (8%)       8 (14%)      2 (3%)                   
   Intestine Large, Cecum                             (70)         (59)         (60)         (59)         (69)                      
      Inflammation, Chronic                            1 (1%)                                                                       
      Parasite Metazoan                                                                       1 (2%)       1 (1%)                   
      Ulcer                                            1 (1%)                                                                       
   Intestine Small, Jejunum                           (70)         (59)         (60)         (58)         (69)                      
      Diverticulum                                                                                         2 (3%)                   
      Inflammation, Chronic, Focal                                                                         1 (1%)                   
      Metaplasia, Focal, Osseous                                                                           1 (1%)                   
      Mucosa, Hyperplasia                                                                     1 (2%)                                
      Mucosa, Hyperplasia, Cystic                                                                          1 (1%)                   
   Intestine Small, Ileum                             (70)         (59)         (60)         (58)         (69)                      
      Inflammation, Chronic, Focal                     1 (1%)                                              2 (3%)                   
      Ulcer                                                                                                1 (1%)                   
   Liver                                              (70)         (60)         (60)         (60)         (70)                      
      Angiectasis                                      1 (1%)       2 (3%)       1 (2%)       3 (5%)       3 (4%)                   
      Basophilic Focus                                32 (46%)     16 (27%)     16 (27%)     10 (17%)     12 (17%)                  
      Clear Cell Focus                                 3 (4%)       4 (7%)       1 (2%)       1 (2%)                                
      Congestion, Focal                                                                       1 (2%)       1 (1%)                   
      Cyst                                                                                    2 (3%)                                
      Degeneration, Cystic                             9 (13%)      6 (10%)     11 (18%)      5 (8%)       7 (10%)                  
      Developmental Malformation                                                                           1 (1%)                   
      Eosinophilic Focus                               3 (4%)       6 (10%)      2 (3%)       2 (3%)       5 (7%)                   
      Fatty Change                                    27 (39%)     25 (42%)     16 (27%)     15 (25%)     19 (27%)                  
      Fibrosis, Focal                                  2 (3%)                                                                       
      Focal Cellular Change                                                      1 (2%)                    2 (3%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05103-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.25%        0.50%        1.00%        2.00%                        
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hematopoietic Cell Proliferation                 1 (1%)       1 (2%)       1 (2%)       3 (5%)       4 (6%)                   
      Hepatodiaphragmatic Nodule                       5 (7%)       2 (3%)       4 (7%)       4 (7%)       5 (7%)                   
      Hepatodiaphragmatic Nodule, Multiple             1 (1%)       1 (2%)                                 1 (1%)                   
      Hyperplasia, Focal, Histiocytic, Lymphoid        1 (1%)                                                                       
      Infarct                                                                    1 (2%)                                             
      Infiltration Cellular, Mixed Cell               10 (14%)      5 (8%)       7 (12%)      8 (13%)     13 (19%)                  
      Inflammation, Focal                             10 (14%)      8 (13%)      6 (10%)      4 (7%)      10 (14%)                  
      Mixed Cell Focus                                 1 (1%)       1 (2%)       1 (2%)       1 (2%)       1 (1%)                   
      Necrosis, Focal                                  7 (10%)      1 (2%)       2 (3%)       4 (7%)       2 (3%)                   
      Pigmentation                                                  1 (2%)                                                          
      Thrombosis                                       1 (1%)                    1 (2%)       1 (2%)                                
      Bile Duct, Dilatation, Focal                                  1 (2%)                    1 (2%)                                
      Bile Duct, Hyperplasia                          55 (79%)     50 (83%)     51 (85%)     43 (72%)     44 (63%)                  
      Biliary Tract, Cyst                              1 (1%)                                                                       
      Centrilobular, Atrophy                          20 (29%)     23 (38%)     31 (52%)     26 (43%)     28 (40%)                  
      Centrilobular, Congestion                                     1 (2%)                                 1 (1%)                   
      Centrilobular, Hemorrhage                        1 (1%)                                                                       
      Centrilobular, Necrosis                                       1 (2%)       1 (2%)       4 (7%)       1 (1%)                   
      Hepatocyte, Hyperplasia, Multifocal              3 (4%)       9 (15%)     10 (17%)      8 (13%)      4 (6%)                   
   Mesentery                                          (16)         (20)         (21)         (23)         (30)                      
      Accessory Spleen                                                           1 (5%)                                             
      Inflammation, Chronic                            1 (6%)       1 (5%)       1 (5%)       2 (9%)       2 (7%)                   
      Fat, Necrosis                                    9 (56%)      9 (45%)      6 (29%)      5 (22%)      7 (23%)                  
   Pancreas                                           (70)         (60)         (60)         (58)         (69)                      
      Accessory Spleen                                 1 (1%)                                                                       
      Atrophy, Diffuse                                                                                     1 (1%)                   
      Atrophy, Focal                                  33 (47%)     23 (38%)     27 (45%)     26 (45%)     22 (32%)                  
      Autolysis                                                     1 (2%)                                                          
      Hyperplasia, Focal                               1 (1%)       1 (2%)       1 (2%)                                             
      Acinar Cell, Focal Cellular Change                                                                   1 (1%)                   
      Acinar Cell, Hyperplasia, Focal                  3 (4%)       9 (15%)     12 (20%)     14 (24%)     27 (39%)                  
      Duct, Dilatation                                 1 (1%)       1 (2%)       2 (3%)                    2 (3%)                   
   Pharynx                                            (1)          (3)          (4)          (5)          (10)                      
      Palate, Epithelium, Hyperplasia, Focal           1 (100%)     1 (33%)      1 (25%)      3 (60%)      2 (20%)                  
   Salivary Glands                                    (70)         (59)         (58)         (60)         (70)                      
      Cyst                                             1 (1%)                                                                       
      Inflammation, Chronic                                                                   1 (2%)                                
   Stomach, Forestomach                               (70)         (60)         (60)         (60)         (69)                      
      Edema                                            1 (1%)       1 (2%)       1 (2%)                                             
      Erosion                                                       3 (5%)                                 1 (1%)                   
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Chronic                            3 (4%)       9 (15%)      4 (7%)       3 (5%)       3 (4%)                   
      Pigmentation                                                  1 (2%)                                                          
      Ulcer                                            1 (1%)       5 (8%)       4 (7%)       2 (3%)       2 (3%)                   
      Mucosa, Cyst                                                  1 (2%)                                                          
      Mucosa, Hyperplasia                              4 (6%)      12 (20%)      6 (10%)      6 (10%)      6 (9%)                   
   Stomach, Glandular                                 (70)         (60)         (60)         (58)         (70)                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05103-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.25%        0.50%        1.00%        2.00%                        
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Edema                                            1 (1%)       1 (2%)                                                          
      Erosion                                          1 (1%)       1 (2%)                    4 (7%)       4 (6%)                   
      Inflammation, Chronic                                         2 (3%)                    2 (3%)                                
      Pigmentation, Focal                              1 (1%)                                 1 (2%)       2 (3%)                   
      Mucosa, Hyperplasia                              1 (1%)                                              2 (3%)                   
   Tongue                                                          (2)          (5)          (13)         (9)                       
      Epithelium, Hyperplasia, Focal                                                          4 (31%)      3 (33%)                  
   Tooth                                              (1)                       (1)                       (2)                       
      Incisor, Dysplasia                               1 (100%)                                            1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (3)          (1)                       (2)          (2)                       
      Mesenteric Artery, Inflammation, Chronic                                                2 (100%)                              
   Heart                                              (69)         (60)         (60)         (60)         (70)                      
      Inflammation, Chronic, Focal                                                            1 (2%)                                
      Mineralization, Focal                                                                   1 (2%)                                
      Thrombosis                                       1 (1%)       1 (2%)       2 (3%)       2 (3%)       2 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (70)         (60)         (60)         (59)         (70)                      
      Accessory Adrenal Cortical Nodule                7 (10%)      4 (7%)       4 (7%)       4 (7%)      11 (16%)                  
      Angiectasis                                                                             1 (2%)       1 (1%)                   
      Atrophy                                                                    1 (2%)                                             
      Congestion                                       3 (4%)                    1 (2%)       2 (3%)       1 (1%)                   
      Focal Cellular Change                            7 (10%)      6 (10%)      6 (10%)     14 (24%)      6 (9%)                   
      Hematopoietic Cell Proliferation                                                        1 (2%)       1 (1%)                   
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Necrosis, Focal                                  2 (3%)                                              1 (1%)                   
      Vacuolization Cytoplasmic                                                  1 (2%)       1 (2%)       1 (1%)                   
   Adrenal Medulla                                    (70)         (60)         (60)         (59)         (70)                      
      Angiectasis                                      1 (1%)                                                                       
      Hyperplasia                                     10 (14%)     15 (25%)     13 (22%)      5 (8%)       9 (13%)                  
   Islets, Pancreatic                                 (70)         (60)         (60)         (60)         (69)                      
      Hyperplasia                                      1 (1%)                                              1 (1%)                   
   Parathyroid Gland                                  (68)         (57)         (58)         (58)         (68)                      
      Hyperplasia                                      4 (6%)                    1 (2%)       1 (2%)       1 (1%)                   
   Pituitary Gland                                    (69)         (58)         (59)         (58)         (67)                      
      Angiectasis                                                   2 (3%)       2 (3%)       3 (5%)                                
      Cyst                                             3 (4%)       2 (3%)       1 (2%)       2 (3%)       6 (9%)                   
      Hemorrhage                                                                              1 (2%)                                
      Pars Distalis, Focal Cellular Change             7 (10%)      3 (5%)       4 (7%)       5 (9%)       6 (9%)                   
      Pars Distalis, Hyperplasia, Focal                5 (7%)       6 (10%)      1 (2%)       2 (3%)       5 (7%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05103-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.25%        0.50%        1.00%        2.00%                        
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (70)         (60)         (60)         (60)         (69)                      
      Ultimobranchial Cyst                             3 (4%)                    1 (2%)       3 (5%)                                
      C-Cell, Hyperplasia                              8 (11%)     11 (18%)      5 (8%)       5 (8%)      15 (22%)                  
      Follicle, Dilatation                                                       1 (2%)       3 (5%)       9 (13%)                  
      Follicular Cell, Hyperplasia                     3 (4%)                    2 (3%)       5 (8%)       6 (9%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (2)          (3)          (6)          (8)                       
      Scrotal, Inflammation, Chronic                                                          1 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                               (1)                       (2)          (3)                       
      Hyperplasia                                                   1 (100%)                  2 (100%)     3 (100%)                 
   Epididymis                                         (70)         (60)         (60)         (59)         (70)                      
      Granuloma Sperm                                                            1 (2%)       1 (2%)                                
      Inflammation, Chronic                                                      1 (2%)       1 (2%)                                
   Preputial Gland                                    (70)         (59)         (60)         (60)         (70)                      
      Degeneration, Cystic                            67 (96%)     59 (100%)    57 (95%)     60 (100%)    64 (91%)                  
      Hyperplasia                                      2 (3%)       3 (5%)       2 (3%)                                             
      Inflammation, Chronic                            5 (7%)       3 (5%)       3 (5%)       3 (5%)       8 (11%)                  
   Prostate                                           (70)         (60)         (60)         (60)         (70)                      
      Inflammation, Suppurative                       33 (47%)     41 (68%)     34 (57%)     40 (67%)     36 (51%)                  
      Epithelium, Hyperplasia, Focal                   3 (4%)       3 (5%)                    1 (2%)                                
   Seminal Vesicle                                    (70)         (60)         (60)         (60)         (70)                      
      Dilatation                                                                              1 (2%)       1 (1%)                   
      Edema                                            1 (1%)                                                                       
      Hyperplasia                                      1 (1%)       8 (13%)      9 (15%)     17 (28%)     33 (47%)                  
      Inflammation, Chronic                            2 (3%)                                                                       
   Testes                                             (70)         (60)         (60)         (60)         (70)                      
      Mineralization, Focal                                                                   1 (2%)                                
      Germinal Epithelium, Degeneration                7 (10%)      7 (12%)      7 (12%)      6 (10%)      4 (6%)                   
      Interstitial Cell, Hyperplasia                   2 (3%)       4 (7%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (60)         (60)         (60)         (70)                      
      Hypercellularity                                 7 (10%)      7 (12%)      6 (10%)     16 (27%)     18 (26%)                  
      Hyperplasia, Focal, Histiocytic                  1 (1%)                                                                       
      Metaplasia, Osseous                                                                     4 (7%)                                
      Myelofibrosis                                    2 (3%)                    1 (2%)       3 (5%)       2 (3%)                   
      Necrosis, Focal                                                                                      1 (1%)                   
   Lymph Node                                         (25)         (23)         (36)         (27)         (31)                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05103-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.25%        0.50%        1.00%        2.00%                        
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Deep Cervical, Hyperplasia                                                                           1 (3%)                   
      Iliac, Hyperplasia                                            1 (4%)                                                          
      Inguinal, Hyperplasia                            2 (8%)                                 1 (4%)                                
      Inguinal, Hyperplasia, Lymphoid                               1 (4%)                                                          
      Mediastinal, Edema                                                                                   2 (6%)                   
      Mediastinal, Hemorrhage                          2 (8%)       3 (13%)      1 (3%)       3 (11%)      4 (13%)                  
      Mediastinal, Hyperplasia                         1 (4%)                                 2 (7%)       2 (6%)                   
      Mediastinal, Hyperplasia, Lymphoid                                         1 (3%)                    1 (3%)                   
      Mediastinal, Pigmentation                                                               1 (4%)       3 (10%)                  
      Mediastinal, Thrombosis                                                    1 (3%)                                             
      Pancreatic, Edema                                                                       1 (4%)                                
      Pancreatic, Hemorrhage                           1 (4%)       1 (4%)                                                          
      Pancreatic, Hyperplasia, Macrophage                           1 (4%)                                                          
   Lymph Node, Mandibular                             (68)         (59)         (58)         (60)         (69)                      
      Congestion                                                    1 (2%)       1 (2%)                                             
      Edema                                            1 (1%)       1 (2%)       1 (2%)       1 (2%)       1 (1%)                   
      Hemorrhage                                       1 (1%)       1 (2%)                                                          
      Hyperplasia                                      4 (6%)       2 (3%)       2 (3%)       3 (5%)      10 (14%)                  
      Pigmentation                                                  1 (2%)                                                          
   Lymph Node, Mesenteric                             (69)         (60)         (60)         (60)         (70)                      
      Edema                                                                      1 (2%)       4 (7%)       3 (4%)                   
      Hemorrhage                                                    2 (3%)                                                          
      Hyperplasia                                      1 (1%)                    1 (2%)       4 (7%)       2 (3%)                   
      Hyperplasia, Lymphoid                            1 (1%)                    1 (2%)                                             
   Spleen                                             (70)         (60)         (60)         (59)         (70)                      
      Autolysis                                                     1 (2%)                                                          
      Congestion                                                                              1 (2%)                                
      Developmental Malformation                       1 (1%)                    2 (3%)       1 (2%)                                
      Fibrosis, Focal                                 16 (23%)     11 (18%)     22 (37%)     24 (41%)     28 (40%)                  
      Hematopoietic Cell Proliferation                 1 (1%)       3 (5%)       3 (5%)       8 (14%)     17 (24%)                  
      Necrosis, Focal                                  1 (1%)                    2 (3%)                    1 (1%)                   
      Pigmentation                                                  1 (2%)                                                          
   Thymus                                             (67)         (60)         (58)         (57)         (67)                      
      Congestion                                                                              1 (2%)                                
      Cyst                                                                                                 1 (1%)                   
      Hemorrhage                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (66)         (58)         (57)         (53)         (60)                      
      Angiectasis                                                                             1 (2%)                                
      Dilatation                                      11 (17%)      9 (16%)     11 (19%)      4 (8%)       4 (7%)                   
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                      3 (5%)       2 (3%)       3 (5%)       1 (2%)       2 (3%)                   
      Inflammation, Chronic                                                                   1 (2%)                                
   Skin                                               (70)         (60)         (60)         (59)         (69)                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05103-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.25%        0.50%        1.00%        2.00%                        
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Cyst Epithelial Inclusion                                     1 (2%)                    1 (2%)       2 (3%)                   
      Hemorrhage, Focal                                                          1 (2%)                                             
      Hyperkeratosis, Focal                            1 (1%)       1 (2%)       3 (5%)       2 (3%)       2 (3%)                   
      Inflammation, Chronic, Focal                                  1 (2%)       1 (2%)       3 (5%)       3 (4%)                   
      Ulcer                                                                                   1 (2%)                                
      Epidermis, Hyperplasia, Focal                    1 (1%)       2 (3%)       2 (3%)       2 (3%)       3 (4%)                   
      Hair Follicle, Cyst                                                                                  1 (1%)                   
      Prepuce, Inflammation, Chronic                                             1 (2%)                                             
      Sebaceous Gland, Cyst                                         1 (2%)                                                          
      Sebaceous Gland, Hyperplasia, Focal                                                     1 (2%)       1 (1%)                   
      Subcutaneous Tissue, Fibrosis                    1 (1%)                    1 (2%)                    1 (1%)                   
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
           Focal                                                                 1 (2%)       2 (3%)                                
      Subcutaneous Tissue, Fat, Necrosis                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (60)         (60)         (60)         (70)                      
      Hyperostosis                                     6 (9%)       7 (12%)      4 (7%)       5 (8%)      11 (16%)                  
      Adventitia, Calvarium, Proliferation                                                                                          
          Connective Tissue                                                                                1 (1%)                   
   Skeletal Muscle                                                 (3)          (2)          (4)          (4)                       
      Hemorrhage, Focal                                                                       1 (25%)                               
      Inflammation, Chronic                                                                   1 (25%)                               
      Necrosis, Focal                                                                         1 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (60)         (60)         (60)         (70)                      
      Compression                                      3 (4%)       7 (12%)      2 (3%)       3 (5%)       3 (4%)                   
      Hemorrhage                                       3 (4%)       3 (5%)       2 (3%)       2 (3%)       1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (60)         (60)         (60)         (70)                      
      Congestion                                       1 (1%)                    3 (5%)       2 (3%)                                
      Hemorrhage, Focal                                             1 (2%)       2 (3%)       1 (2%)       1 (1%)                   
      Hyperplasia, Diffuse, Histiocytic                                          1 (2%)                                             
      Hyperplasia, Focal, Histiocytic                                                         1 (2%)                                
      Inflammation, Chronic, Focal                                  2 (3%)       1 (2%)                    1 (1%)                   
      Metaplasia, Osseous                              1 (1%)                                              1 (1%)                   
      Alveolar Epithelium, Hyperplasia                 3 (4%)       4 (7%)       5 (8%)       7 (12%)     14 (20%)                  
      Peribronchial, Infiltration Cellular,                                                                                         
          Lymphocyte                                                                                       1 (1%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05103-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.25%        0.50%        1.00%        2.00%                        
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Nose                                               (70)         (60)         (60)         (60)         (70)                      
      Fungus                                           7 (10%)      3 (5%)       6 (10%)      5 (8%)       5 (7%)                   
      Inflammation, Suppurative                       12 (17%)      8 (13%)     17 (28%)     11 (18%)     11 (16%)                  
      Mucosa, Angiectasis, Focal                                                 1 (2%)                                             
      Mucosa, Hyperkeratosis, Focal                                              1 (2%)                                             
      Mucosa, Hyperplasia, Focal                                                 2 (3%)                                             
      Mucosa, Metaplasia, Focal, Squamous                                        2 (3%)                                             
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                                                                           1 (1%)                   
      Respiratory Epithelium, Hyperplasia, Focal                                                           1 (1%)                   
   Trachea                                            (70)         (60)         (60)         (60)         (70)                      
      Glands, Dilatation                                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)          (3)                       (1)                       
      Atrophy                                                       1 (100%)     1 (33%)                                            
      Cataract                                         1 (50%)                   2 (67%)                                            
      Fibrosis                                                      1 (100%)                                                        
      Inflammation, Chronic                            1 (50%)                                                                      
      Synechia                                         1 (50%)                   1 (33%)                                            
      Cornea, Inflammation, Chronic                                              1 (33%)                                            
      Retina, Degeneration                                          1 (100%)     1 (33%)                                            
      Sclera, Mineralization, Focal                                                                        1 (100%)                 
   Zymbal's Gland                                     (2)          (1)          (5)          (5)          (15)                      
      Dilatation                                                                              1 (20%)      1 (7%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (60)         (60)         (60)         (69)                      
      Atrophy, Focal                                                                          6 (10%)                               
      Cyst                                             2 (3%)                                 1 (2%)       1 (1%)                   
      Hydronephrosis                                                                                       1 (1%)                   
      Infarct                                          1 (1%)                                                                       
      Inflammation, Chronic, Suppurative                            1 (2%)                    1 (2%)                                
      Nephropathy                                     70 (100%)    60 (100%)    60 (100%)    58 (97%)     61 (88%)                  
      Cortex, Medulla, Mineralization, Focal                                                  1 (2%)                                
      Papilla, Degeneration                                         5 (8%)      32 (53%)     33 (55%)     24 (35%)                  
      Papilla, Mineralization, Focal                                                          2 (3%)                                
      Papilla, Epithelium, Hyperplasia                11 (16%)     20 (33%)     26 (43%)     52 (87%)     21 (30%)                  
      Pelvis, Dilatation                                            1 (2%)                    1 (2%)       1 (1%)                   
      Pelvis, Transitional Epithelium, Hyperplasia                                            4 (7%)       4 (6%)                   
      Renal Tubule, Epithelium, Hyperplasia, Focal                               2 (3%)                                             
   Urethra                                            (1)          (1)          (1)          (1)                                    
      Bulbourethral Gland, Dilatation                  1 (100%)                  1 (100%)     1 (100%)                              
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05103-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.25%        0.50%        1.00%        2.00%                        
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
   Urinary Bladder                                    (70)         (60)         (60)         (60)         (69)                      
      Dilatation                                                    1 (2%)                                                          
      Hemorrhage                                                                                           1 (1%)                   
      Inflammation, Chronic                            1 (1%)                                 1 (2%)       2 (3%)                   
      Transitional Epithelium, Hyperplasia                                       1 (2%)       3 (5%)      20 (29%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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