TDMS Study 05103-05 Pathology Tables
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
Facility: Southern Research Institute
Chemical CAS #: 3296-90-0
Lock Date: 02/18/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 4| 1| 6| 1| 8| 3| 3| 3| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4|
| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 6| 1| 3| 9| 9| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 |
Eosinophilic Focus | |
Fatty Change | 3 3 2 2 3|
Focal Cellular Change | 2 2 1 2 2 1 2 1 2 2 2 2 1 2 2 2 1 2 2 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 |
Inflammation, Focal | 1 2 1 1 1 1 1 |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 2 2 1 1 2 2 1 1 1 2 1 2 |
Centrilobular, Atrophy | 2 3 3 2 2 2|
Hepatocyte, Hyperplasia, Multifocal | 1 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + +|
Accessory Spleen | 2 |
Fat, Necrosis | 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Atrophy, Focal | 1 2 1 3 1 1 |
Fibrosis, Focal | 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic | |
Ulcer, Multiple | |
Mucosa, Hyperplasia | 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 1|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 4| 1| 6| 1| 8| 3| 3| 3| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4|
| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 6| 1| 3| 9| 9| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 |
Angiectasis | |
Focal Cellular Change | 2 2 1 2 2 3 2 |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 2 |
Vacuolization Cytoplasmic | 3|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 3 3 |
Cyst | 2 2 |
Pars Distalis, Angiectasis | |
Pars Distalis, Focal Cellular Change | 2 2 3 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + M + + +|
Degeneration, Cystic | 1 3 1 2 3 3 4 2 2 1 3 2 2 1 3 2 2 3 3 1|
Hyperplasia | 2 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Corpus Luteum, Hyperplasia, Lymphoid | 1 |
Corpus Luteum, Thecal Cell, | |
Hyperplasia | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 1 |
Inflammation, Suppurative | |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | 2 2 |
Endometrium, Inflammation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 4| 1| 6| 1| 8| 3| 3| 3| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4|
| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 6| 1| 3| 9| 9| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 3 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Inguinal, Hyperplasia | 3 |
Mediastinal, Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 4 |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 3 2 2 2 2 2 2 3 2 2 3 2 3 2 2 2 2 2|
Hyperplasia | 2 2 1 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | 1 |
Epidermis, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 3 2 1 3 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 3 2 4 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hyperplasia, Focal, Macrophage | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 4| 1| 6| 1| 8| 3| 3| 3| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4|
| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 6| 1| 3| 9| 9| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
Cataract | |
Fibrosis | |
Synechia | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic, Suppurative | |
Nephropathy | 2 1 1 1 1 1 1 1 2 1 1 1 1 2 2 2 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 9| 4| 4| 8| 4| 3| 3| 9| 5| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 9| 3| 3| 3|
| 6| 0| 0| 9| 0| 9| 9| 4| 4| 9| 9| 9| 2| 9| 9| 0| 9| 9| 9| 9| 9| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | |
Eosinophilic Focus | |
Fatty Change | 3 3 2 2 |
Focal Cellular Change | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 3 2|
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 2 3 2 2 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 1 1 2 1 2 1 2 |
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 1 1 1 3 2 1 2 2 1 1 2 2|
Centrilobular, Atrophy | 2 1 3 2 2 |
Hepatocyte, Hyperplasia, Multifocal | 3 2 |
__________________________________________________________________________|
Mesentery | + |
Accessory Spleen | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | 2 |
Atrophy, Focal | 2 3 1 2 2 2 1 1 1 2 3 1 1 2|
Fibrosis, Focal | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Chronic | 2 |
Ulcer, Multiple | 2 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Erosion | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 9| 4| 4| 8| 4| 3| 3| 9| 5| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 9| 3| 3| 3|
| 6| 0| 0| 9| 0| 9| 9| 4| 4| 9| 9| 9| 2| 9| 9| 0| 9| 9| 9| 9| 9| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 2 |
Angiectasis | 2 |
Focal Cellular Change | 1 2 1 2 |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Angiectasis | 3 3 2 3 2 2 3 |
Cyst | 1 2 2 3 |
Pars Distalis, Angiectasis | |
Pars Distalis, Focal Cellular Change | 2 2 1 |
Pars Distalis, Hyperplasia, Focal | 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 1 1 2 2 2 2 1 1 3 1 1 2 1 2 2 2 2|
Hyperplasia | 2 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 2 2 2 |
Corpus Luteum, Hyperplasia, Lymphoid | 3 |
Corpus Luteum, Thecal Cell, | |
Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Inflammation, Suppurative | 1 |
Endometrium, Cyst | 1 |
Endometrium, Hyperplasia, Cystic | 2 |
Endometrium, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 9| 4| 4| 8| 4| 3| 3| 9| 5| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 9| 3| 3| 3|
| 6| 0| 0| 9| 0| 9| 9| 4| 4| 9| 9| 9| 2| 9| 9| 0| 9| 9| 9| 9| 9| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 2 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Inguinal, Hyperplasia | |
Mediastinal, Hemorrhage | 2 2 3 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
Cyst | 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 4 2 3 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2|
Hyperplasia | 1 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | |
Epidermis, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 3|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + M|
Compression | 3 4 2 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Hyperplasia, Focal, Macrophage | 3 |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + M|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 9| 4| 4| 8| 4| 3| 3| 9| 5| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 9| 3| 3| 3|
| 6| 0| 0| 9| 0| 9| 9| 4| 4| 9| 9| 9| 2| 9| 9| 0| 9| 9| 9| 9| 9| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + +|
Atrophy | 3 3|
Cataract | 3 3 3|
Fibrosis | 2 |
Synechia | 3 |
Retina, Degeneration | 3 4|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Chronic, Suppurative | 1 |
Nephropathy | 2 1 2 3 1 1 1 1 1 1 1 2 1 1 1 3 2 1 1 2 1 1 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Parasite Metazoan | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 2 1.5|
Basophilic Focus | | 1 2.0|
Eosinophilic Focus | 3 | 1 3.0|
Fatty Change | | 9 2.6|
Focal Cellular Change | 1 1 1 | 42 1.8|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | 2 | 6 2.2|
Infiltration Cellular, Mixed Cell | | 4 2.0|
Inflammation, Focal | 1 2 1 1 1 1 | 20 1.3|
Necrosis, Focal | | 1 1.0|
Bile Duct, Hyperplasia | 1 1 | 26 1.5|
Centrilobular, Atrophy | | 11 2.2|
Hepatocyte, Hyperplasia, Multifocal | | 8 2.0|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Accessory Spleen | | 1 2.0|
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Accessory Spleen | | 1 2.0|
Atrophy, Focal | 1 1 1 1 | 24 1.5|
Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Ulcer, Multiple | | 1 2.0|
Mucosa, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 3 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | 1 | 5 1.2|
Angiectasis | | 1 2.0|
Focal Cellular Change | | 11 1.8|
Hyperplasia, Histiocytic | | 2 2.0|
Hyperplasia, Lymphoid | | 2 2.0|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + | 58 |
Angiectasis | 2 1 2 1 2 2 | 18 2.3|
Cyst | 3 | 7 2.1|
Pars Distalis, Angiectasis | 3 | 1 3.0|
Pars Distalis, Focal Cellular Change | 2 | 8 2.0|
Pars Distalis, Hyperplasia, Focal | 1 2 | 9 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia | | 8 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 58 |
Degeneration, Cystic | 1 1 3 1 2 1 1 2 | 48 1.8|
Hyperplasia | 2 1 | 4 1.8|
Inflammation, Chronic | | 2 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | 2 | 7 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Corpus Luteum, Hyperplasia, Lymphoid | | 2 2.0|
Corpus Luteum, Thecal Cell, | | |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | 2 | 2 1.5|
Inflammation, Suppurative | | 1 1.0|
Endometrium, Cyst | | 1 1.0|
Endometrium, Hyperplasia, Cystic | 1 | 4 1.8|
Endometrium, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 5 2.6|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 16 |
Inguinal, Hyperplasia | | 1 3.0|
Mediastinal, Hemorrhage | | 6 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Hemorrhage | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 11 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Fibrosis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
Cyst | | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 1 1 | 44 2.1|
Hyperplasia | | 7 1.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Hyperkeratosis, Focal | | 1 1.0|
Epidermis, Hyperplasia, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Hyperostosis | 1 2 | 10 2.2|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Compression | | 9 2.8|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Fibrosis, Focal | | 1 2.0|
Hyperplasia, Focal, Macrophage | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Atrophy | | 2 3.0|
Cataract | | 3 3.0|
Fibrosis | | 1 2.0|
Synechia | | 1 3.0|
Retina, Degeneration | | 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 2.0|
Inflammation, Chronic, Suppurative | | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 | 56 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 9| 2| 5| 2| 2| 3| 3| 8| 8| 3| 4| 3| 3| 1| 0| 3| 3| 3| 3| 3| 2| 9|
| 9| 9| 0| 5| 5| 6| 5| 3| 9| 9| 3| 0| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0.25% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Intussusception | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | 2 |
Fatty Change | 2 1 1 2 4 3 1|
Focal Cellular Change | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2|
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 2 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 2 1 1 1 2 1 1 1|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 1 2 2 1 3 |
Biliary Tract, Cyst | |
Centrilobular, Atrophy | 3 2 2 2 3 3 |
Hepatocyte, Hyperplasia, Multifocal | 2 2 2 2 3 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | 2 |
Atrophy, Focal | 1 2 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Chronic | 3 |
Ulcer | 2 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Erosion | 1 |
Pigmentation, Focal | 1 |
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 9| 2| 5| 2| 2| 3| 3| 8| 8| 3| 4| 3| 3| 1| 0| 3| 3| 3| 3| 3| 2| 9|
| 9| 9| 0| 5| 5| 6| 5| 3| 9| 9| 3| 0| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0.25% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 1 |
Angiectasis | 2 |
Focal Cellular Change | 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 3 |
Cyst | 1 2 2 2 2 |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Focal Cellular Change | 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 3 2 |
Pars Distalis, Pigmentation | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + M + + + + + + + +|
Degeneration, Cystic | 3 2 1 4 3 3 2 2 1 3 3 3 3 1 1 1 2 3 2 3 1|
Hyperplasia | 1 |
Inflammation, Chronic | 4 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 1 |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Inflammation, Suppurative | |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 9| 2| 5| 2| 2| 3| 3| 8| 8| 3| 4| 3| 3| 1| 0| 3| 3| 3| 3| 3| 2| 9|
| 9| 9| 0| 5| 5| 6| 5| 3| 9| 9| 3| 0| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0.25% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Metaplasia, Osseous | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Mediastinal, Hemorrhage | 3 3 |
Mediastinal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hemorrhage | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 3 3 3 2 3 3 4 4 3 3 3 4 3 3 3 2 1 1 1 3 |
Hyperplasia | 2 3 2 2 2 3 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 3 3 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 4 4 3 4 3 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic, Focal | |
Pleura, Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 9| 2| 5| 2| 2| 3| 3| 8| 8| 3| 4| 3| 3| 1| 0| 3| 3| 3| 3| 3| 2| 9|
| 9| 9| 0| 5| 5| 6| 5| 3| 9| 9| 3| 0| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0.25% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fungus | 2 |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 |
Nephropathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 3 1 2 1 1 2 1 2 1 1 1|
Papilla, Degeneration | |
Papilla, Epithelium, Hyperplasia | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 8| 3| 0| 1| 3| 7| 3| 3| 2| 3| 0| 3| 9| 3| 3| 3| 0| 8| 0| 3| 3| 3| 0| 3|
| 9| 4| 9| 9| 9| 9| 6| 9| 9| 2| 9| 1| 9| 5| 9| 8| 8| 4| 4| 4| 9| 9| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Intussusception | 4 |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fatty Change | 3 2 3 2 3 |
Focal Cellular Change | 2 2 2 1 2 4 2 2 2 2 2 2 2 2 1 2 2 2 2 2|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 2 2 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Focal | 1 2 2 2 1 1 1 2 1 |
Bile Duct, Hyperplasia | 1 1 2 1 1 2 2 1 1 2 2 2 1 |
Biliary Tract, Cyst | 3|
Centrilobular, Atrophy | 2 2 3 3 |
Hepatocyte, Hyperplasia, Multifocal | 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Fat, Necrosis | 3 2 2 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Atrophy, Focal | 1 2 1 2 1 1 1 2 1 |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Pigmentation, Focal | |
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 8| 3| 0| 1| 3| 7| 3| 3| 2| 3| 0| 3| 9| 3| 3| 3| 0| 8| 0| 3| 3| 3| 0| 3|
| 9| 4| 9| 9| 9| 9| 6| 9| 9| 2| 9| 1| 9| 5| 9| 8| 8| 4| 4| 4| 9| 9| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Angiectasis | |
Focal Cellular Change | 1 1 3 2 2 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 2 2 2 2 3|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | |
Pars Distalis, Focal Cellular Change | 1 |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 2 2 1 3 2 2 3 2 3 3 2 1 1 1 2 1 3 2 1 2 2|
Hyperplasia | 2 2 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 3 |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Inflammation, Suppurative | 2 |
Endometrium, Cyst | 2 2 |
Endometrium, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 3 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 8| 3| 0| 1| 3| 7| 3| 3| 2| 3| 0| 3| 9| 3| 3| 3| 0| 8| 0| 3| 3| 3| 0| 3|
| 9| 4| 9| 9| 9| 9| 6| 9| 9| 2| 9| 1| 9| 5| 9| 8| 8| 4| 4| 4| 9| 9| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Metaplasia, Osseous | 1 |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + M + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 2 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + I + + + + + +|
Cyst | 3 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 3 4 3 3 2 2 4 3 2 4 2 2 2 3 2 4 2 |
Hyperplasia | 2 2 3 3 2 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 2 3 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Inflammation, Chronic, Focal | 2 |
Pleura, Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 8| 3| 0| 1| 3| 7| 3| 3| 2| 3| 0| 3| 9| 3| 3| 3| 0| 8| 0| 3| 3| 3| 0| 3|
| 9| 4| 9| 9| 9| 9| 6| 9| 9| 2| 9| 1| 9| 5| 9| 8| 8| 4| 4| 4| 9| 9| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fungus | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Lacrimal Gland | + |
__________________________________________________________________________|
Zymbal's Gland | M |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Nephropathy | 1 1 1 1 2 2 1 1 1 1 1 2 1 1 3 1 1 1 1 1 1 1 2 1|
Papilla, Degeneration | 1 |
Papilla, Epithelium, Hyperplasia | 1 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Intussusception | | 1 4.0|
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | 2 | 4 1.3|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Developmental Malformation | | 1 2.0|
Fatty Change | | 12 2.3|
Focal Cellular Change | 2 1 2 2 1 1 1 2 | 48 1.9|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | 2 2 | 5 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Focal | 1 1 | 19 1.3|
Bile Duct, Hyperplasia | | 24 1.7|
Biliary Tract, Cyst | | 1 3.0|
Centrilobular, Atrophy | | 10 2.5|
Hepatocyte, Hyperplasia, Multifocal | | 10 2.1|
__________________________________________________________________________|____________|
Mesentery | | 12 |
Fat, Necrosis | | 9 2.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Accessory Spleen | | 1 2.0|
Atrophy, Focal | 1 2 2 1 2 | 17 1.4|
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Ulcer | | 1 2.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
Erosion | | 1 1.0|
Pigmentation, Focal | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | + | 3 |
Epithelium, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 4 1.3|
Angiectasis | | 1 2.0|
Focal Cellular Change | | 16 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 59 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | 3 3 3 2 3 | 10 2.6|
Cyst | 1 3 | 12 2.0|
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Cyst | 2 | 1 2.0|
Pars Distalis, Focal Cellular Change | 2 1 | 5 1.6|
Pars Distalis, Hyperplasia, Focal | | 4 2.3|
Pars Distalis, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | | 14 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 58 |
Degeneration, Cystic | 2 2 3 1 1 1 | 50 2.0|
Hyperplasia | | 4 1.8|
Inflammation, Chronic | | 2 3.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Cyst | 2 | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Bilateral, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | 2 1 | 2 1.5|
Inflammation, Suppurative | | 1 2.0|
Endometrium, Cyst | | 2 2.0|
Endometrium, Hyperplasia, Cystic | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 4 2.5|
Metaplasia, Osseous | | 1 1.0|
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 11 |
Mediastinal, Hemorrhage | | 3 3.0|
Mediastinal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 57 |
Hemorrhage | | 1 2.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Hemorrhage | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Congestion | | 2 3.0|
Hematopoietic Cell Proliferation | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
Cyst | | 2 2.5|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 2 2 2 1 | 45 2.6|
Hyperplasia | | 12 2.4|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Alopecia | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 3 2 | 10 2.5|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 10 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 1.0|
Inflammation, Chronic, Focal | | 1 2.0|
Pleura, Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 1 2.0|
Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 2.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Atrophy, Focal | | 2 1.5|
Nephropathy | 1 1 1 1 1 1 1 1 | 57 1.2|
Papilla, Degeneration | | 1 1.0|
Papilla, Epithelium, Hyperplasia | | 1 1.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 2.0|
Renal Tubule, Epithelium, | | |
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 5| 7| 6| 7| 5| 6| 7| 7| 7| 4| 6| 6| 5| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 9| 3| 7| 3| 9| 2| 6| 9| 3| 3| 3| 8| 9| 6| 0| 3| 8| 6| 7| 3|
| 8| 0| 8| 8| 8| 7| 1| 6| 8| 4| 6| 5| 6| 8| 8| 8| 1| 7| 0| 8| 8| 2| 2| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.50% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion, Focal | |
Fatty Change | 2 2 1 2 3 |
Focal Cellular Change | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2|
Hemorrhage, Focal | 2 |
Hepatodiaphragmatic Nodule | 2 3 |
Hepatodiaphragmatic Nodule, Multiple | |
Hyperplasia, Histiocytic, Lymphoid | |
Hyperplasia, Histiocytic | |
Infiltration Cellular, Mixed Cell | 1 2 1 2 |
Inflammation, Focal | 1 1 1 2 2 1 1 |
Necrosis, Focal | 2 2 |
Bile Duct, Hyperplasia | 1 1 1 2 1 1 2 1 1 2 |
Centrilobular, Atrophy | 2 2 2 2 3 |
Centrilobular, Congestion | |
Hepatocyte, Hyperplasia, Multifocal | 2 2 3 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 1 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | 2 |
Atrophy, Focal | 1 1 1 2 2 3 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Tongue | + + |
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
Incisor, Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 5| 7| 6| 7| 5| 6| 7| 7| 7| 4| 6| 6| 5| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 9| 3| 7| 3| 9| 2| 6| 9| 3| 3| 3| 8| 9| 6| 0| 3| 8| 6| 7| 3|
| 8| 0| 8| 8| 8| 7| 1| 6| 8| 4| 6| 5| 6| 8| 8| 8| 1| 7| 0| 8| 8| 2| 2| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.50% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 1 |
Angiectasis | 2 2 |
Congestion | 2 3 |
Focal Cellular Change | 3 2 1 2 1 2 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Cyst | 2 2 2 |
Hemorrhage | |
Pars Distalis, Focal Cellular Change | 1 1 2 2|
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + M + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 3 1 2 3 2 2 1 2 3 1 2 1 3 3 3 3|
Dilatation | 3 |
Hyperplasia | 2 2|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Corpus Luteum, Hyperplasia, Lymphoid | 2 |
Corpus Luteum, Thecal Cell, | |
Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Cyst | 2 2 |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 5| 7| 6| 7| 5| 6| 7| 7| 7| 4| 6| 6| 5| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 9| 3| 7| 3| 9| 2| 6| 9| 3| 3| 3| 8| 9| 6| 0| 3| 8| 6| 7| 3|
| 8| 0| 8| 8| 8| 7| 1| 6| 8| 4| 6| 5| 6| 8| 8| 8| 1| 7| 0| 8| 8| 2| 2| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.50% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 2 3 3 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Deep Cervical, Hyperplasia | 2 |
Mediastinal, Hemorrhage | 1 |
Mediastinal, Hyperplasia | |
Pancreatic, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 3 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 2 2 4 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + M + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 3 2 3 3 3 1 3 3 2 2 2 4 2|
Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 3 3 1 3 |
Hemorrhage | 3 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic, Focal | 1 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 5| 7| 6| 7| 5| 6| 7| 7| 7| 4| 6| 6| 5| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 9| 3| 7| 3| 9| 2| 6| 9| 3| 3| 3| 8| 9| 6| 0| 3| 8| 6| 7| 3|
| 8| 0| 8| 8| 8| 7| 1| 6| 8| 4| 6| 5| 6| 8| 8| 8| 1| 7| 0| 8| 8| 2| 2| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.50% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fungus | 2 |
Inflammation, Suppurative | 2 2 |
Nasolacrimal Duct, Cyst | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Atrophy | |
Cataract | 3 |
Hemorrhage | 3 |
Inflammation, Chronic | 4 |
Necrosis, Focal | 4 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 2 2 1 2 1 1 2 1 1 2 2|
Papilla, Degeneration | 2 |
Papilla, Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 4| 6|
DAY ON TEST | 9| 7| 8| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 9| 0| 3| 3| 0| 3| 7|
| 5| 0| 5| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 2| 9| 8| 8| 5| 4| 8| 3| 9| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.50% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion, Focal | 1 |
Fatty Change | 3 2 3 3 2 2|
Focal Cellular Change | 1 2 2 2 2 1 1 2 2 2 2 2 2 2 3 |
Hemorrhage, Focal | |
Hepatodiaphragmatic Nodule | |
Hepatodiaphragmatic Nodule, Multiple | |
Hyperplasia, Histiocytic, Lymphoid | 2 |
Hyperplasia, Histiocytic | |
Infiltration Cellular, Mixed Cell | 2 2|
Inflammation, Focal | 2 1 1 2 1 1 1 1 |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 3 1 2 2 2|
Centrilobular, Atrophy | 1 2 4 3 2 |
Centrilobular, Congestion | 3 |
Hepatocyte, Hyperplasia, Multifocal | 2 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Atrophy, Focal | 2 1 2 2 1 2 2 1 2 1 1 1|
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
__________________________________________________________________________|
Tongue | + + + +|
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | 3 |
Incisor, Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 4| 6|
DAY ON TEST | 9| 7| 8| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 9| 0| 3| 3| 0| 3| 7|
| 5| 0| 5| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 2| 9| 8| 8| 5| 4| 8| 3| 9| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.50% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Angiectasis | |
Congestion | 3 |
Focal Cellular Change | 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 2 1 2 |
Cyst | 2 1 1 2 2 2 2|
Hemorrhage | 3 |
Pars Distalis, Focal Cellular Change | 2 2|
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + M + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 2 2 2 2 2 3 3 1 2 1 3 3 2 1 4 2 1 3|
Dilatation | |
Hyperplasia | 2 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 1 |
Corpus Luteum, Hyperplasia, Lymphoid | 2 2 |
Corpus Luteum, Thecal Cell, | |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Cyst | 2 2 |
Endometrium, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 4| 6|
DAY ON TEST | 9| 7| 8| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 9| 0| 3| 3| 0| 3| 7|
| 5| 0| 5| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 2| 9| 8| 8| 5| 4| 8| 3| 9| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.50% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 2 3|
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Deep Cervical, Hyperplasia | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia | 3|
Pancreatic, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 3|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 3 |
Hematopoietic Cell Proliferation | 2 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 3 3 4 3 3 3 2 2 2 3 3 2 2 4 3 3|
Hyperplasia | 2 3 3 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 2 3 3 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 1 |
Hemorrhage | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 4| 6|
DAY ON TEST | 9| 7| 8| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 9| 0| 3| 3| 0| 3| 7|
| 5| 0| 5| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 2| 9| 8| 8| 5| 4| 8| 3| 9| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.50% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fungus | 1 2 |
Inflammation, Suppurative | 2 2 |
Nasolacrimal Duct, Cyst | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 3 |
Cataract | |
Hemorrhage | |
Inflammation, Chronic | |
Necrosis, Focal | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Nephropathy | 1 1 1 2 1 1 1 1 2 1 1 1 2 2 1 1 1 2 1 1 2 2 1 2 1|
Papilla, Degeneration | 1 2 |
Papilla, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 4| 4| 4| 4| 4| 4| 3| | |
DAY ON TEST | 8| 3| 5| 5| 5| 5| 5| 5| 5| 8| | |
| 3| 8| 6| 6| 6| 6| 6| 6| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A |
0.50% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Congestion, Focal | | 1 1.0|
Fatty Change | | 11 2.3|
Focal Cellular Change | 2 2 1 1 2 1 1 | 43 1.8|
Hemorrhage, Focal | | 1 2.0|
Hepatodiaphragmatic Nodule | 1 | 3 2.0|
Hepatodiaphragmatic Nodule, Multiple | 3 | 1 3.0|
Hyperplasia, Histiocytic, Lymphoid | | 1 2.0|
Hyperplasia, Histiocytic | 1 | 1 1.0|
Infiltration Cellular, Mixed Cell | | 6 1.7|
Inflammation, Focal | 1 1 1 1 | 19 1.2|
Necrosis, Focal | | 2 2.0|
Bile Duct, Hyperplasia | | 21 1.4|
Centrilobular, Atrophy | | 10 2.3|
Centrilobular, Congestion | | 1 3.0|
Hepatocyte, Hyperplasia, Multifocal | 2 | 7 2.1|
__________________________________________________________________________|____________|
Mesentery | + + | 9 |
Fat, Necrosis | 2 3 | 7 2.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Accessory Spleen | | 1 2.0|
Atrophy, Focal | 2 1 2 1 | 22 1.5|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Mucosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 6 |
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 4| 4| 4| 4| 4| 4| 3| | |
DAY ON TEST | 8| 3| 5| 5| 5| 5| 5| 5| 5| 8| | |
| 3| 8| 6| 6| 6| 6| 6| 6| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A |
0.50% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Developmental Malformation | | 1 3.0|
Incisor, Dysplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 4 1.0|
Angiectasis | 2 | 3 2.0|
Congestion | | 3 2.7|
Focal Cellular Change | 1 | 8 1.6|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 4 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 59 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Angiectasis | 2 2 | 9 1.9|
Cyst | 2 3 | 12 1.9|
Hemorrhage | | 1 3.0|
Pars Distalis, Focal Cellular Change | 1 | 7 1.6|
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | 2 | 1 2.0|
C-Cell, Hyperplasia | | 18 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 56 |
Degeneration, Cystic | 2 2 1 1 2 1 1 1 | 46 2.0|
Dilatation | | 1 3.0|
Hyperplasia | | 4 2.0|
Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 4| 4| 4| 4| 4| 4| 3| | |
DAY ON TEST | 8| 3| 5| 5| 5| 5| 5| 5| 5| 8| | |
| 3| 8| 6| 6| 6| 6| 6| 6| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A |
0.50% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | 2 | 5 1.8|
Corpus Luteum, Hyperplasia, Lymphoid | | 3 2.0|
Corpus Luteum, Thecal Cell, | | |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Endometrium, Cyst | | 4 2.0|
Endometrium, Hyperplasia, Cystic | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | 2 | 11 2.4|
__________________________________________________________________________|____________|
Lymph Node | + | 15 |
Deep Cervical, Hyperplasia | | 1 2.0|
Mediastinal, Hemorrhage | | 1 1.0|
Mediastinal, Hyperplasia | | 1 3.0|
Pancreatic, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Hemorrhage | | 2 2.5|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis, Focal | 2 | 4 2.3|
Hematopoietic Cell Proliferation | | 7 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
Congestion | | 1 3.0|
Hemorrhage | | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 3 2 2 2 | 37 2.6|
Hyperplasia | | 8 2.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 4| 4| 4| 4| 4| 4| 3| | |
DAY ON TEST | 8| 3| 5| 5| 5| 5| 5| 5| 5| 8| | |
| 3| 8| 6| 6| 6| 6| 6| 6| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A |
0.50% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 3 | 10 2.4|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 9 2.7|
Hemorrhage | | 2 2.5|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Inflammation, Chronic, Focal | | 2 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 3 1.7|
Inflammation, Suppurative | | 4 2.0|
Nasolacrimal Duct, Cyst | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Atrophy | | 1 3.0|
Cataract | | 1 3.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 4.0|
Necrosis, Focal | | 1 4.0|
Retina, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Atrophy, Focal | | 1 2.0|
Nephropathy | 1 2 1 1 1 1 1 1 | 56 1.3|
Papilla, Degeneration | | 3 1.7|
Papilla, Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 4| 4| 4| 4| 4| 4| 3| | |
DAY ON TEST | 8| 3| 5| 5| 5| 5| 5| 5| 5| 8| | |
| 3| 8| 6| 6| 6| 6| 6| 6| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A |
0.50% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 6| 4| 6| 6| 6| 6| 6| 6| 7| 6| 5| 6| 7| 5| 6| 5| 5| 5| 6|
DAY ON TEST | 5| 3| 6| 3| 8| 2| 8| 3| 2| 4| 8| 8| 1| 1| 3| 3| 9| 3| 2| 7| 8| 9| 4| 8| 7|
| 1| 1| 9| 0| 5| 5| 9| 2| 5| 5| 2| 4| 9| 0| 8| 1| 4| 4| 5| 4| 0| 8| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.00% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Autolysis | 3 |
Fatty Change | 1 3 2 2 |
Focal Cellular Change | 1 3 2 2 2 2 2 3 2 1 2 2 2 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 2 2 |
Hepatodiaphragmatic Nodule, Multiple | |
Infiltration Cellular, Mixed Cell | 2 2 2 |
Inflammation, Focal | 1 2 1 1 2|
Necrosis, Focal | 1 2 2 |
Bile Duct, Hyperplasia | 2 1 2 2 2 2 2 1 2 1|
Centrilobular, Atrophy | 3 2 3 1 3 2 2 3 3 |
Centrilobular, Degeneration | |
Hepatocyte, Hyperplasia, Multifocal | 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic | 1 |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 2 1 3 1 |
__________________________________________________________________________|
Pharynx | + |
Palate, Epithelium, Hyperplasia, | |
Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | 2 |
Pigmentation | 1 |
Ulcer | 2 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
__________________________________________________________________________|
Tongue | + + + |
Inflammation, Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 6| 4| 6| 6| 6| 6| 6| 6| 7| 6| 5| 6| 7| 5| 6| 5| 5| 5| 6|
DAY ON TEST | 5| 3| 6| 3| 8| 2| 8| 3| 2| 4| 8| 8| 1| 1| 3| 3| 9| 3| 2| 7| 8| 9| 4| 8| 7|
| 1| 1| 9| 0| 5| 5| 9| 2| 5| 5| 2| 4| 9| 0| 8| 1| 4| 4| 5| 4| 0| 8| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.00% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 |
Angiectasis | |
Congestion | 2 2 |
Focal Cellular Change | 2 1 2 3 2 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
Angiectasis | 2 3 2 |
Cyst | 2 2 2 2 2 2 |
Pars Distalis, Angiectasis | |
Pars Distalis, Focal Cellular Change | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 1 |
C-Cell, Hyperplasia | 1 1 2 1 2 |
Follicle, Dilatation | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 2 1 3 3 2 2 1 4 4 2 3 1 3 3 2 2 1 3 2 2 2|
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 2 |
Corpus Luteum, Hyperplasia, Lymphoid | 3 |
Corpus Luteum, Thecal Cell, | |
Hyperplasia | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 1 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 6| 4| 6| 6| 6| 6| 6| 6| 7| 6| 5| 6| 7| 5| 6| 5| 5| 5| 6|
DAY ON TEST | 5| 3| 6| 3| 8| 2| 8| 3| 2| 4| 8| 8| 1| 1| 3| 3| 9| 3| 2| 7| 8| 9| 4| 8| 7|
| 1| 1| 9| 0| 5| 5| 9| 2| 5| 5| 2| 4| 9| 0| 8| 1| 4| 4| 5| 4| 0| 8| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.00% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cervix, Hyperplasia | |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 2 2 3 2 2 2 1 |
Hyperplasia, Focal, Histiocytic | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Axillary, Hyperplasia | |
Iliac, Inflammation, Suppurative | |
Inguinal, Hyperplasia | |
Mediastinal, Hemorrhage | 1 |
Mediastinal, Pigmentation | |
Renal, Hyperplasia | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 1 2 2 |
Hematopoietic Cell Proliferation | 3 2 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 1 2 1 2 2 2 2 2 3 3 3 2 2 2 2 2 |
Hyperplasia | 3 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 2 2|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 1 2 |
Hemorrhage | 3 |
__________________________________________________________________________|
Peripheral Nerve | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 6| 4| 6| 6| 6| 6| 6| 6| 7| 6| 5| 6| 7| 5| 6| 5| 5| 5| 6|
DAY ON TEST | 5| 3| 6| 3| 8| 2| 8| 3| 2| 4| 8| 8| 1| 1| 3| 3| 9| 3| 2| 7| 8| 9| 4| 8| 7|
| 1| 1| 9| 0| 5| 5| 9| 2| 5| 5| 2| 4| 9| 0| 8| 1| 4| 4| 5| 4| 0| 8| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.00% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Diffuse | |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Suppurative | |
Mucosa, Hyperplasia, Focal | |
Nasolacrimal Duct, Cyst | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 3 3 3 3|
Cyst | 3 |
Nephropathy | 1 2 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 3 1 1 2 2 1 1 1|
Papilla, Degeneration | 2 1 2 1 2 2 2 3|
Papilla, Epithelium, Hyperplasia | 1 2 1|
Pelvis, Dilatation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 6| 6| 4| 5| 6| 5| 7| 6| 7| 6| 5| 5| 7| 5| 6| 6| 4| 7|
DAY ON TEST | 6| 2| 3| 2| 3| 3| 9| 8| 6| 6| 1| 8| 9| 3| 8| 2| 9| 2| 9| 0| 0| 5| 8| 7| 2|
| 0| 7| 8| 2| 8| 8| 4| 2| 0| 0| 6| 3| 2| 8| 3| 6| 4| 3| 2| 9| 9| 9| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.00% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Autolysis | |
Fatty Change | 2 2 1 2 |
Focal Cellular Change | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 1 2 1 2 1 2|
Hematopoietic Cell Proliferation | 2 2 2 |
Hepatodiaphragmatic Nodule | 2 2 2 2 1 3 |
Hepatodiaphragmatic Nodule, Multiple | 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 |
Inflammation, Focal | 1 2 1 2 2 1 2 1 |
Necrosis, Focal | 2 2 2 1|
Bile Duct, Hyperplasia | 1 1 1 2 1 1 3 3 1 |
Centrilobular, Atrophy | 2 2 2 2 3 |
Centrilobular, Degeneration | 3 |
Hepatocyte, Hyperplasia, Multifocal | 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | 2 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 2 1 2 1 1 3 |
__________________________________________________________________________|
Pharynx | + |
Palate, Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | |
Pigmentation | |
Ulcer | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Tongue | + + |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 6| 6| 4| 5| 6| 5| 7| 6| 7| 6| 5| 5| 7| 5| 6| 6| 4| 7|
DAY ON TEST | 6| 2| 3| 2| 3| 3| 9| 8| 6| 6| 1| 8| 9| 3| 8| 2| 9| 2| 9| 0| 0| 5| 8| 7| 2|
| 0| 7| 8| 2| 8| 8| 4| 2| 0| 0| 6| 3| 2| 8| 3| 6| 4| 3| 2| 9| 9| 9| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.00% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Angiectasis | 4 |
Congestion | |
Focal Cellular Change | 2 2 2 2 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 |
Cyst | 2 1 2 2 2 2 |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Focal Cellular Change | |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 2 |
C-Cell, Hyperplasia | 1 1 1 2 1 1 2 1 2|
Follicle, Dilatation | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 1 2 3 2 3 2 3 2 1 2 2 3 1 1 2 1 2 1 2 2 3 2 2|
Hyperplasia | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 1 |
Corpus Luteum, Hyperplasia, Lymphoid | |
Corpus Luteum, Thecal Cell, | |
Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 1 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 6| 6| 4| 5| 6| 5| 7| 6| 7| 6| 5| 5| 7| 5| 6| 6| 4| 7|
DAY ON TEST | 6| 2| 3| 2| 3| 3| 9| 8| 6| 6| 1| 8| 9| 3| 8| 2| 9| 2| 9| 0| 0| 5| 8| 7| 2|
| 0| 7| 8| 2| 8| 8| 4| 2| 0| 0| 6| 3| 2| 8| 3| 6| 4| 3| 2| 9| 9| 9| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.00% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cervix, Hyperplasia | 3 |
Endometrium, Cyst | 3 3 |
Endometrium, Hyperplasia, Cystic | 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 |
Hyperplasia, Focal, Histiocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Axillary, Hyperplasia | 3 |
Iliac, Inflammation, Suppurative | 3 |
Inguinal, Hyperplasia | 2 |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Pigmentation | 2 |
Renal, Hyperplasia | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 2 |
Hematopoietic Cell Proliferation | 3 3 3 4 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 2 3 3 3 3 4 3 4 3 |
Hyperplasia | 2 3 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 4 |
Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 6| 6| 4| 5| 6| 5| 7| 6| 7| 6| 5| 5| 7| 5| 6| 6| 4| 7|
DAY ON TEST | 6| 2| 3| 2| 3| 3| 9| 8| 6| 6| 1| 8| 9| 3| 8| 2| 9| 2| 9| 0| 0| 5| 8| 7| 2|
| 0| 7| 8| 2| 8| 8| 4| 2| 0| 0| 6| 3| 2| 8| 3| 6| 4| 3| 2| 9| 9| 9| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.00% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage, Diffuse | 3 |
Inflammation, Chronic, Focal | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Suppurative | 2 2 |
Mucosa, Hyperplasia, Focal | 2 |
Nasolacrimal Duct, Cyst | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 |
Cyst | |
Nephropathy | 1 1 2 1 1 1 2 3 1 1 2 1 1 1 1 1 1 1 1 3 1 1 1|
Papilla, Degeneration | 2 1 4 3 1 3 2 1|
Papilla, Epithelium, Hyperplasia | 1 1 1 |
Pelvis, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 7| 1| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 0| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.00% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 2 | 2 2.0|
Autolysis | | 1 3.0|
Fatty Change | | 8 1.9|
Focal Cellular Change | 2 1 3 2 2 2 1 1 | 42 1.9|
Hematopoietic Cell Proliferation | | 3 2.0|
Hepatodiaphragmatic Nodule | 3 | 9 2.1|
Hepatodiaphragmatic Nodule, Multiple | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 6 2.0|
Inflammation, Focal | 1 1 1 1 1 1 | 19 1.3|
Necrosis, Focal | | 7 1.7|
Bile Duct, Hyperplasia | | 19 1.6|
Centrilobular, Atrophy | 2 | 15 2.3|
Centrilobular, Degeneration | | 1 3.0|
Hepatocyte, Hyperplasia, Multifocal | 2 | 7 2.0|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Inflammation, Chronic | | 2 1.5|
Fat, Necrosis | | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy, Focal | 2 1 | 16 1.6|
__________________________________________________________________________|____________|
Pharynx | | 2 |
Palate, Epithelium, Hyperplasia, | | |
Focal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Pigmentation | | 1 1.0|
Ulcer | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 7| 1| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 0| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.00% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 6 |
Inflammation, Chronic, Focal | | 1 3.0|
Epithelium, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 3 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 3 1.0|
Angiectasis | | 1 4.0|
Congestion | | 2 2.0|
Focal Cellular Change | 2 | 11 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Angiectasis | 2 2 2 | 9 2.2|
Cyst | | 12 1.9|
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Focal Cellular Change | 2 2 | 2 2.0|
Pars Distalis, Hyperplasia, Focal | 2 3 | 6 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | | 4 1.8|
C-Cell, Hyperplasia | | 14 1.4|
Follicle, Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 2 3 1 1 1 3 3 2 | 56 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 7| 1| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 0| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.00% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | 2 | 7 2.3|
Corpus Luteum, Hyperplasia, Lymphoid | | 1 3.0|
Corpus Luteum, Thecal Cell, | | |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | | 4 1.8|
Inflammation, Suppurative | | 1 2.0|
Cervix, Hyperplasia | | 1 3.0|
Endometrium, Cyst | | 2 3.0|
Endometrium, Hyperplasia, Cystic | 2 1 | 7 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 10 2.1|
Hyperplasia, Focal, Histiocytic | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 19 |
Axillary, Hyperplasia | | 1 3.0|
Iliac, Inflammation, Suppurative | | 1 3.0|
Inguinal, Hyperplasia | | 1 2.0|
Mediastinal, Hemorrhage | | 2 1.5|
Mediastinal, Pigmentation | | 1 2.0|
Renal, Hyperplasia | 2 | 1 2.0|
Renal, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Hemorrhage | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + | 13 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis, Focal | | 5 1.8|
Hematopoietic Cell Proliferation | | 10 2.9|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 3 3 2 2 2 1 | 34 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 7| 1| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 0| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.00% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 2 2 | 10 2.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | | 4 2.5|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 4 2.5|
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Hemorrhage, Diffuse | | 1 3.0|
Inflammation, Chronic, Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 4 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 1 2.0|
Inflammation, Suppurative | | 2 2.0|
Mucosa, Hyperplasia, Focal | | 1 2.0|
Nasolacrimal Duct, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Atrophy, Focal | 3 | 7 2.9|
Cyst | | 1 3.0|
Nephropathy | 2 1 1 1 1 1 1 1 1 | 57 1.3|
Papilla, Degeneration | 4 | 17 2.1|
Papilla, Epithelium, Hyperplasia | 3 | 7 1.4|
Pelvis, Dilatation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 7| 1| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 0| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.00% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 4| 6| 7| 6| 7|
DAY ON TEST | 9| 7| 1| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 8| 6| 3| 3| 9| 8| 6| 1| 2| 2|
| 6| 5| 9| 5| 9| 7| 8| 7| 7| 4| 7| 7| 7| 7| 2| 2| 7| 7| 7| 7| 1| 3| 6| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 1 1 1 1 1 2 1 1 1 2 1 1 |
Clear Cell Focus | 1 |
Degeneration, Cystic | 2 1 2 1 2|
Eosinophilic Focus | 1 2 |
Fatty Change | 2 3 2 2 2 3 2 2 3 3 |
Fibrosis, Focal | 2 2 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 2 2 2 |
Hepatodiaphragmatic Nodule, Multiple | 2 |
Hyperplasia, Focal, Histiocytic, | |
Lymphoid | |
Infiltration Cellular, Mixed Cell | 2 2 2 2 |
Inflammation, Focal | 2 2 2 |
Mixed Cell Focus | |
Necrosis, Focal | 2 2 2 2 |
Thrombosis | 3 |
Bile Duct, Hyperplasia | 3 3 3 2 2 3 3 2 2 3 3 2 2 2 2 2 2 1 2 2 3 2|
Biliary Tract, Cyst | |
Centrilobular, Atrophy | 3 2 4 2 4 2 2 2 2 3 4 3 |
Centrilobular, Hemorrhage | 4 |
Hepatocyte, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Inflammation, Chronic | 2 |
Fat, Necrosis | 2 3 2 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Atrophy, Focal | 2 1 2 2 2 1 1 1 3 2 2 1 2 1 |
Hyperplasia, Focal | |
Acinar Cell, Hyperplasia, Focal | 2 1 |
Duct, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 4| 6| 7| 6| 7|
DAY ON TEST | 9| 7| 1| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 8| 6| 3| 3| 9| 8| 6| 1| 2| 2|
| 6| 5| 9| 5| 9| 7| 8| 7| 7| 4| 7| 7| 7| 7| 2| 2| 7| 7| 7| 7| 1| 3| 6| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pharynx | |
Palate, Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Chronic | 1 |
Ulcer | |
Mucosa, Hyperplasia | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Erosion | 2 |
Pigmentation, Focal | 2 |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Tooth | |
Incisor, Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 1 1 |
Congestion | 2 2 |
Focal Cellular Change | 2 |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 1 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Focal Cellular Change | 1 2 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 2 |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 4| 6| 7| 6| 7|
DAY ON TEST | 9| 7| 1| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 8| 6| 3| 3| 9| 8| 6| 1| 2| 2|
| 6| 5| 9| 5| 9| 7| 8| 7| 7| 4| 7| 7| 7| 7| 2| 2| 7| 7| 7| 7| 1| 3| 6| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 3 3 2 2 3 3 2 2 1 3 1 2 1 2 3 3 2 2 3 3 2 3 3|
Hyperplasia | 4 2 |
Inflammation, Chronic | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 2 2 2 1 1 2 2 1 4 2 1 1|
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hyperplasia | 1 |
Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 3 |
Interstitial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 3 3 2 |
Hyperplasia, Focal, Histiocytic | 2 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia | 2 |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia | |
Pancreatic, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | 2 |
Hyperplasia | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis, Focal | 1 1 2 2 1 2 3 3 2|
Hematopoietic Cell Proliferation | 3 |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 4| 6| 7| 6| 7|
DAY ON TEST | 9| 7| 1| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 8| 6| 3| 3| 9| 8| 6| 1| 2| 2|
| 6| 5| 9| 5| 9| 7| 8| 7| 7| 4| 7| 7| 7| 7| 2| 2| 7| 7| 7| 7| 1| 3| 6| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + M|
Dilatation | 2 4 1 3 2 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | 2 |
Epidermis, Hyperplasia, Focal | 2 |
Subcutaneous Tissue, Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 1 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 |
Hemorrhage | 3 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 2 4|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 2 2 |
Inflammation, Suppurative | 2 2 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Inflammation, Chronic | |
Synechia | |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Infarct | 4 |
Nephropathy | 3 2 2 2 2 2 3 2 1 1 3 3 2 2 2 4 1 2 2 1 1 2 2 2 2|
Papilla, Epithelium, Hyperplasia | 1 1 1 1|
__________________________________________________________________________|
Urethra | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 4| 6| 7| 6| 7|
DAY ON TEST | 9| 7| 1| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 8| 6| 3| 3| 9| 8| 6| 1| 2| 2|
| 6| 5| 9| 5| 9| 7| 8| 7| 7| 4| 7| 7| 7| 7| 2| 2| 7| 7| 7| 7| 1| 3| 6| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Bulbourethral Gland, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 0| 3| 3| 2| 3| 6| 2| 1| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3|
| 1| 7| 7| 7| 3| 7| 7| 8| 7| 0| 5| 9| 6| 6| 6| 6| 9| 5| 6| 1| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 |
Clear Cell Focus | 1 1 |
Degeneration, Cystic | 2 2 2 2 |
Eosinophilic Focus | 1|
Fatty Change | 3 2 2 2 2 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 2|
Hepatodiaphragmatic Nodule, Multiple | |
Hyperplasia, Focal, Histiocytic, | |
Lymphoid | 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 3 2 2 |
Inflammation, Focal | 1 |
Mixed Cell Focus | 2 |
Necrosis, Focal | 1 2 |
Thrombosis | |
Bile Duct, Hyperplasia | 2 3 2 2 3 2 2 2 3 2 2 3 2 2 2 2 3 3 2 3 2 2 2 1 2|
Biliary Tract, Cyst | 4 |
Centrilobular, Atrophy | 3 3 3 2 4 2 3 2 |
Centrilobular, Hemorrhage | |
Hepatocyte, Hyperplasia, Multifocal | 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Inflammation, Chronic | |
Fat, Necrosis | 1 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Atrophy, Focal | 1 2 2 1 2 2 2 3 2 3 1 1 |
Hyperplasia, Focal | |
Acinar Cell, Hyperplasia, Focal | 2 |
Duct, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 0| 3| 3| 2| 3| 6| 2| 1| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3|
| 1| 7| 7| 7| 3| 7| 7| 8| 7| 0| 5| 9| 6| 6| 6| 6| 9| 5| 6| 1| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pharynx | |
Palate, Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic | 2 3 |
Ulcer | 2 |
Mucosa, Hyperplasia | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Pigmentation, Focal | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 2 |
Congestion | 2 |
Focal Cellular Change | 1 1 1 1 1 1|
Necrosis, Focal | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia | 2 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 |
Pars Distalis, Focal Cellular Change | 1 |
Pars Distalis, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 2 1 2 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 0| 3| 3| 2| 3| 6| 2| 1| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3|
| 1| 7| 7| 7| 3| 7| 7| 8| 7| 0| 5| 9| 6| 6| 6| 6| 9| 5| 6| 1| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 2 2 3 1 3 2 1 3 2 3 2 3 3 2 3 3 4 2 2 3 2|
Hyperplasia | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 2 2 2 2 3 3 2 1 1 1 |
Epithelium, Hyperplasia, Focal | 2 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 4 4 4 4 4 4|
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 |
Hyperplasia, Focal, Histiocytic | |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Inguinal, Hyperplasia | 2 |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia | 2 |
Pancreatic, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Edema | 2 |
Hemorrhage | |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Lymphoid | |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis, Focal | 2 2 1 3 3 |
Hematopoietic Cell Proliferation | |
Necrosis, Focal | 4 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 0| 3| 3| 2| 3| 6| 2| 1| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3|
| 1| 7| 7| 7| 3| 7| 7| 8| 7| 0| 5| 9| 6| 6| 6| 6| 9| 5| 6| 1| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Dilatation | 2 2 2 2 3 2 |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | |
Epidermis, Hyperplasia, Focal | |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 1 2|
Inflammation, Suppurative | 2 1 1 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
Inflammation, Chronic | 3 |
Synechia | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Infarct | |
Nephropathy | 2 2 2 2 2 2 3 2 1 2 3 2 3 2 2 3 2 2 3 2 2 4 3 2 2|
Papilla, Epithelium, Hyperplasia | 1 1 1 1 1 1|
__________________________________________________________________________|
Urethra | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 0| 3| 3| 2| 3| 6| 2| 1| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3|
| 1| 7| 7| 7| 3| 7| 7| 8| 7| 0| 5| 9| 6| 6| 6| 6| 9| 5| 6| 1| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Bulbourethral Gland, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 70 |
Parasite Metazoan | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 70 |
Parasite Metazoan | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic | | 1 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | | 1 2.0|
Basophilic Focus | 1 1 1 1 1 | 32 1.1|
Clear Cell Focus | | 3 1.0|
Degeneration, Cystic | | 9 1.8|
Eosinophilic Focus | | 3 1.3|
Fatty Change | 2 1 2 2 2 2 1 2 2 2 2 2 | 27 2.1|
Fibrosis, Focal | | 2 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | 2 | 5 2.0|
Hepatodiaphragmatic Nodule, Multiple | | 1 2.0|
Hyperplasia, Focal, Histiocytic, | | |
Lymphoid | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 10 2.1|
Inflammation, Focal | 1 1 1 2 1 1 | 10 1.4|
Mixed Cell Focus | | 1 2.0|
Necrosis, Focal | 1 | 7 1.7|
Thrombosis | | 1 3.0|
Bile Duct, Hyperplasia | 2 1 1 1 1 2 2 1 | 55 2.1|
Biliary Tract, Cyst | | 1 4.0|
Centrilobular, Atrophy | | 20 2.8|
Centrilobular, Hemorrhage | | 1 4.0|
Hepatocyte, Hyperplasia, Multifocal | | 3 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 16 |
Inflammation, Chronic | | 1 2.0|
Fat, Necrosis | 3 | 9 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Accessory Spleen | 1 | 1 1.0|
Atrophy, Focal | 2 1 1 2 1 1 1 | 33 1.6|
Hyperplasia, Focal | 2 | 1 2.0|
Acinar Cell, Hyperplasia, Focal | | 3 1.7|
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Palate, Epithelium, Hyperplasia, | | |
Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Edema | | 1 3.0|
Inflammation, Chronic | | 3 2.0|
Ulcer | | 1 2.0|
Mucosa, Hyperplasia | | 4 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Edema | | 1 3.0|
Erosion | | 1 2.0|
Pigmentation, Focal | | 1 2.0|
Mucosa, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Incisor, Dysplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 3 |
__________________________________________________________________________|____________|
Heart | + + M + + + + + + + + + + + + + + + + + | 69 |
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Accessory Adrenal Cortical Nodule | | 7 1.1|
Congestion | | 3 2.0|
Focal Cellular Change | | 7 1.1|
Necrosis, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | | 1 3.0|
Hyperplasia | 1 | 10 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + | 68 |
Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Cyst | 1 | 3 2.0|
Pars Distalis, Focal Cellular Change | 2 2 | 7 1.7|
Pars Distalis, Hyperplasia, Focal | 2 | 5 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Ultimobranchial Cyst | 1 2 1 | 3 1.3|
C-Cell, Hyperplasia | | 8 1.5|
Follicular Cell, Hyperplasia | 1 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Degeneration, Cystic | 1 3 2 3 3 2 2 2 1 2 2 2 2 1 2 2 1 1 1 | 67 2.2|
Hyperplasia | | 2 3.0|
Inflammation, Chronic | 3 2 | 5 2.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Suppurative | 2 1 2 1 2 2 1 1 | 33 1.8|
Epithelium, Hyperplasia, Focal | | 3 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 |
Edema | | 1 3.0|
Hyperplasia | | 1 1.0|
Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
Germinal Epithelium, Degeneration | | 7 3.9|
Interstitial Cell, Hyperplasia | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Hypercellularity | | 7 2.7|
Hyperplasia, Focal, Histiocytic | | 1 2.0|
Myelofibrosis | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | | 25 |
Inguinal, Hyperplasia | | 2 2.0|
Mediastinal, Hemorrhage | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hyperplasia | | 1 2.0|
Pancreatic, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 68 |
Edema | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 21 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Developmental Malformation | 1 | 1 1.0|
Fibrosis, Focal | 2 1 | 16 1.9|
Hematopoietic Cell Proliferation | | 1 3.0|
Necrosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + + + + + + + | 67 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + | 66 |
Dilatation | | 11 2.3|
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperkeratosis, Focal | | 1 2.0|
Epidermis, Hyperplasia, Focal | | 1 2.0|
Subcutaneous Tissue, Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperostosis | | 6 1.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Compression | | 3 3.0|
Hemorrhage | | 3 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Congestion | | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Fungus | | 7 1.9|
Inflammation, Suppurative | 1 2 | 12 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Synechia | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | | 2 2.0|
Infarct | | 1 4.0|
Nephropathy | 3 2 2 2 2 2 2 2 1 2 1 1 1 1 1 1 1 1 1 1 | 70 2.0|
Papilla, Epithelium, Hyperplasia | 1 | 11 1.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Bulbourethral Gland, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 5| 5| 2| 6| 4| 5| 7| 7| 7| 6| 4| 6|
DAY ON TEST | 9| 3| 5| 3| 1| 3| 3| 7| 6| 9| 3| 1| 3| 4| 1| 3| 8| 5| 8| 3| 3| 3| 6| 8| 4|
| 5| 6| 0| 6| 6| 6| 6| 5| 8| 6| 6| 1| 6| 3| 2| 5| 1| 1| 6| 6| 6| 6| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 4 1 1 1 1 1 1 1 |
Clear Cell Focus | 1 1 |
Degeneration, Cystic | 2 2 1 |
Eosinophilic Focus | |
Fatty Change | 2 2 2 2 1 1 1 1 1 3 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 3 |
Hepatodiaphragmatic Nodule, Multiple | |
Infiltration Cellular, Mixed Cell | 1 1 2 |
Inflammation, Focal | 2 1 1 |
Mixed Cell Focus | |
Necrosis, Focal | 1 |
Pigmentation | |
Bile Duct, Dilatation, Focal | 2 |
Bile Duct, Hyperplasia | 3 2 3 2 3 2 3 3 2 1 3 1 1 2 2 2 1 2 3 2|
Centrilobular, Atrophy | 4 2 2 2 3 3 3 2 3 3 |
Centrilobular, Congestion | 3 |
Centrilobular, Necrosis | 2|
Hepatocyte, Hyperplasia, Multifocal | 2 3 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Inflammation, Chronic | |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 2 1 2 1 1 |
Autolysis | 4 |
Hyperplasia, Focal | |
Acinar Cell, Hyperplasia, Focal | 2 2 |
Duct, Dilatation | 1 |
__________________________________________________________________________|
Pharynx | + |
Palate, Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 5| 5| 2| 6| 4| 5| 7| 7| 7| 6| 4| 6|
DAY ON TEST | 9| 3| 5| 3| 1| 3| 3| 7| 6| 9| 3| 1| 3| 4| 1| 3| 8| 5| 8| 3| 3| 3| 6| 8| 4|
| 5| 6| 0| 6| 6| 6| 6| 5| 8| 6| 6| 1| 6| 3| 2| 5| 1| 1| 6| 6| 6| 6| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 2 |
Hyperplasia | |
Inflammation, Chronic | 2 1 3 3 |
Pigmentation | |
Ulcer | 3 2 |
Mucosa, Cyst | 2|
Mucosa, Hyperplasia | 2 1 1 3 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tongue | + I |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Focal Cellular Change | 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + M|
Angiectasis | |
Cyst | 2 |
Pars Distalis, Focal Cellular Change | 2 |
Pars Distalis, Hyperplasia, Focal | 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Hyperplasia | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 3 3 3 2 2 3 3 1 2 2 2 2 3 2 2 3 2 2 3 3 2 2 3|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 5| 5| 2| 6| 4| 5| 7| 7| 7| 6| 4| 6|
DAY ON TEST | 9| 3| 5| 3| 1| 3| 3| 7| 6| 9| 3| 1| 3| 4| 1| 3| 8| 5| 8| 3| 3| 3| 6| 8| 4|
| 5| 6| 0| 6| 6| 6| 6| 5| 8| 6| 6| 1| 6| 3| 2| 5| 1| 1| 6| 6| 6| 6| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 3 |
Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 3 3 2 2 1 2 2 3 1 2 1 2 1 3 1 2 1|
Epithelium, Hyperplasia, Focal | 1 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 3 4 4 3 3 |
Interstitial Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 3 2 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Iliac, Hyperplasia | 3 |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hemorrhage | 3 2 |
Pancreatic, Hemorrhage | 3 |
Pancreatic, Hyperplasia, Macrophage | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +|
Congestion | 2 |
Edema | 2 |
Hemorrhage | |
Hyperplasia | 2 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Fibrosis, Focal | 2 2 2 2 3 |
Hematopoietic Cell Proliferation | 2 3|
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Dilatation | 3 2 2 3 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 5| 5| 2| 6| 4| 5| 7| 7| 7| 6| 4| 6|
DAY ON TEST | 9| 3| 5| 3| 1| 3| 3| 7| 6| 9| 3| 1| 3| 4| 1| 3| 8| 5| 8| 3| 3| 3| 6| 8| 4|
| 5| 6| 0| 6| 6| 6| 6| 5| 8| 6| 6| 1| 6| 3| 2| 5| 1| 1| 6| 6| 6| 6| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperkeratosis, Focal | |
Inflammation, Chronic, Focal | 3 |
Epidermis, Hyperplasia, Focal | 2 |
Sebaceous Gland, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 2 3 |
__________________________________________________________________________|
Skeletal Muscle | + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 4 3 |
Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 |
Inflammation, Suppurative | 2 2 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | |
Atrophy | |
Fibrosis | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Suppurative | 1 |
Nephropathy | 3 2 1 3 2 2 3 2 1 2 3 3 3 2 3 1 3 1 1 2 3 3 2 2 1|
Papilla, Degeneration | 1 1 2 1 2 |
Papilla, Epithelium, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 |
Pelvis, Dilatation | |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 5| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7|
DAY ON TEST | 4| 2| 3| 1| 3| 8| 4| 5| 3| 6| 3| 5| 7| 3| 3| 6| 3| 3| 2| 1| 7| 2| 8| 2| 3|
| 8| 5| 6| 0| 6| 6| 8| 5| 6| 7| 6| 9| 5| 6| 6| 2| 6| 6| 0| 2| 6| 6| 1| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Basophilic Focus | 1 2 2 1 1 1|
Clear Cell Focus | 1 1 |
Degeneration, Cystic | 1 1 2 |
Eosinophilic Focus | 2 2 3 3 1 |
Fatty Change | 3 2 1 2 2 2 3 1 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 3 |
Hepatodiaphragmatic Nodule, Multiple | |
Infiltration Cellular, Mixed Cell | 1 1 |
Inflammation, Focal | 1 1|
Mixed Cell Focus | 2 |
Necrosis, Focal | |
Pigmentation | 2 |
Bile Duct, Dilatation, Focal | |
Bile Duct, Hyperplasia | 3 2 2 3 2 2 3 1 3 2 3 2 2 2 2 3 2 2 2 3 1 1 2|
Centrilobular, Atrophy | 4 2 1 3 2 3 1 3 2 3 2 2 |
Centrilobular, Congestion | |
Centrilobular, Necrosis | |
Hepatocyte, Hyperplasia, Multifocal | 3 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Inflammation, Chronic | 3 |
Fat, Necrosis | 1 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 2 2 2 2 2 3 2 2 2 |
Autolysis | |
Hyperplasia, Focal | |
Acinar Cell, Hyperplasia, Focal | 2 1 2 2 1 2 |
Duct, Dilatation | |
__________________________________________________________________________|
Pharynx | + |
Palate, Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 5| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7|
DAY ON TEST | 4| 2| 3| 1| 3| 8| 4| 5| 3| 6| 3| 5| 7| 3| 3| 6| 3| 3| 2| 1| 7| 2| 8| 2| 3|
| 8| 5| 6| 0| 6| 6| 8| 5| 6| 7| 6| 9| 5| 6| 6| 2| 6| 6| 0| 2| 6| 6| 1| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 2 2 |
Hyperplasia | |
Inflammation, Chronic | 2 1 3 2 2 |
Pigmentation | 3 |
Ulcer | 2 2 2 |
Mucosa, Cyst | |
Mucosa, Hyperplasia | 2 2 1 3 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 1 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tongue | +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 1 |
Focal Cellular Change | 2 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 1 1 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 2 |
Pars Distalis, Focal Cellular Change | 2 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Hyperplasia | 1 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Degeneration, Cystic | 3 3 3 3 1 3 3 2 2 2 2 2 2 1 3 3 2 3 3 2 2 3 3 3|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 5| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7|
DAY ON TEST | 4| 2| 3| 1| 3| 8| 4| 5| 3| 6| 3| 5| 7| 3| 3| 6| 3| 3| 2| 1| 7| 2| 8| 2| 3|
| 8| 5| 6| 0| 6| 6| 8| 5| 6| 7| 6| 9| 5| 6| 6| 2| 6| 6| 0| 2| 6| 6| 1| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 3 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 2 2 1 3 2 2 2 3 3 1 1 2 |
Epithelium, Hyperplasia, Focal | 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 3 3 |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Iliac, Hyperplasia | |
Inguinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hemorrhage | 2 |
Pancreatic, Hemorrhage | |
Pancreatic, Hyperplasia, Macrophage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | |
Hemorrhage | 2 |
Hyperplasia | |
Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Fibrosis, Focal | 2 2 2 |
Hematopoietic Cell Proliferation | 4 |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Dilatation | 2 2 2 3 2 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 2 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 5| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7|
DAY ON TEST | 4| 2| 3| 1| 3| 8| 4| 5| 3| 6| 3| 5| 7| 3| 3| 6| 3| 3| 2| 1| 7| 2| 8| 2| 3|
| 8| 5| 6| 0| 6| 6| 8| 5| 6| 7| 6| 9| 5| 6| 6| 2| 6| 6| 0| 2| 6| 6| 1| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperkeratosis, Focal | 1 |
Inflammation, Chronic, Focal | |
Epidermis, Hyperplasia, Focal | 1 |
Sebaceous Gland, Cyst | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 3 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 3 |
Hemorrhage | 2 2 |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Inflammation, Chronic, Focal | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
Fibrosis | 3 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Suppurative | |
Nephropathy | 2 1 2 1 2 1 2 2 4 2 2 2 2 3 2 3 3 3 2 1 1 3 4 2 3|
Papilla, Degeneration | |
Papilla, Epithelium, Hyperplasia | 1 2 2 2 1 2 1 1 1 |
Pelvis, Dilatation | |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Parasite Metazoan | 2 1 2 | 4 1.8|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 2 1.5|
Basophilic Focus | 1 | 16 1.3|
Clear Cell Focus | | 4 1.0|
Degeneration, Cystic | | 6 1.5|
Eosinophilic Focus | 4 | 6 2.5|
Fatty Change | 1 2 2 2 2 2 2 | 25 1.8|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | | 2 3.0|
Hepatodiaphragmatic Nodule, Multiple | 3 | 1 3.0|
Infiltration Cellular, Mixed Cell | | 5 1.2|
Inflammation, Focal | 1 1 2 | 8 1.3|
Mixed Cell Focus | | 1 2.0|
Necrosis, Focal | | 1 1.0|
Pigmentation | | 1 2.0|
Bile Duct, Dilatation, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 2 1 1 2 1 | 50 2.1|
Centrilobular, Atrophy | 2 | 23 2.5|
Centrilobular, Congestion | | 1 3.0|
Centrilobular, Necrosis | | 1 2.0|
Hepatocyte, Hyperplasia, Multifocal | 2 | 9 2.2|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 20 |
Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | 3 3 3 3 | 9 2.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy, Focal | 3 2 2 1 1 | 23 1.8|
Autolysis | | 1 4.0|
Hyperplasia, Focal | 1 | 1 1.0|
Acinar Cell, Hyperplasia, Focal | 3 | 9 1.9|
Duct, Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Palate, Epithelium, Hyperplasia, | | |
Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
Erosion | | 3 2.0|
Hyperplasia | 1 | 1 1.0|
Inflammation, Chronic | | 9 2.1|
Pigmentation | | 1 3.0|
Ulcer | | 5 2.2|
Mucosa, Cyst | | 1 2.0|
Mucosa, Hyperplasia | | 12 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Erosion | | 1 1.0|
Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Tongue | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 4 1.0|
Focal Cellular Change | | 6 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 15 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Angiectasis | 2 | 2 2.0|
Cyst | | 2 2.0|
Pars Distalis, Focal Cellular Change | | 3 1.7|
Pars Distalis, Hyperplasia, Focal | 2 2 | 6 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | 1 | 11 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | 2 2 3 2 2 1 2 2 2 2 | 59 2.4|
Hyperplasia | | 3 2.7|
Inflammation, Chronic | | 3 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 1 2 1 1 1 2 1 1 | 41 1.8|
Epithelium, Hyperplasia, Focal | | 3 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Hyperplasia | 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Germinal Epithelium, Degeneration | | 7 3.3|
Interstitial Cell, Hyperplasia | 1 | 4 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | 2 | 7 2.4|
__________________________________________________________________________|____________|
Lymph Node | + + | 23 |
Iliac, Hyperplasia | | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hemorrhage | | 3 2.3|
Pancreatic, Hemorrhage | | 1 3.0|
Pancreatic, Hyperplasia, Macrophage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Congestion | | 1 2.0|
Edema | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia | | 2 2.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Hemorrhage | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + | 12 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Fibrosis, Focal | 2 2 1 | 11 2.0|
Hematopoietic Cell Proliferation | | 3 3.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 60 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
Dilatation | | 9 2.3|
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 2.0|
Hyperkeratosis, Focal | | 1 1.0|
Inflammation, Chronic, Focal | | 1 3.0|
Epidermis, Hyperplasia, Focal | | 2 1.5|
Sebaceous Gland, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | | 7 2.1|
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 7 3.1|
Hemorrhage | 3 | 3 2.3|
__________________________________________________________________________|____________|
Spinal Cord | + + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage, Focal | | 1 2.0|
Inflammation, Chronic, Focal | 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 4 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 2 | 3 2.0|
Inflammation, Suppurative | 3 2 | 8 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 4.0|
Fibrosis | | 1 3.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Inflammation, Chronic, Suppurative | | 1 1.0|
Nephropathy | 2 2 3 2 2 1 2 2 2 2 | 60 2.2|
Papilla, Degeneration | | 5 1.4|
Papilla, Epithelium, Hyperplasia | 1 | 20 1.3|
Pelvis, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 6| 6| 7| 7| 6| 6| 6| 6| 7| 5| 6|
DAY ON TEST | 2| 2| 4| 3| 4| 0| 3| 3| 3| 9| 3| 6| 8| 3| 8| 4| 3| 3| 2| 6| 9| 0| 3| 7| 8|
| 1| 6| 1| 6| 1| 3| 3| 6| 6| 6| 6| 6| 4| 6| 1| 1| 6| 6| 0| 6| 4| 8| 1| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.50% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 1 1 1 1 1 |
Clear Cell Focus | 1 |
Degeneration, Cystic | 2 2 2 1 |
Eosinophilic Focus | |
Fatty Change | 2 2 2 |
Focal Cellular Change | 2 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | |
Infarct | 3 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 1 |
Mixed Cell Focus | 2 |
Necrosis, Focal | 2 |
Thrombosis | 1 |
Bile Duct, Hyperplasia | 2 2 3 2 2 2 2 2 3 1 3 3 2 3 3 2 2 2 2 1 2 2 3|
Centrilobular, Atrophy | 3 3 3 3 3 3 3 3 3 2 2 3 2 3 3 3|
Centrilobular, Necrosis | 1 |
Hepatocyte, Hyperplasia, Multifocal | 2 2 2 2 2 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + +|
Accessory Spleen | |
Inflammation, Chronic | |
Fat, Necrosis | 2 2 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 2 2 1 1 2 2 3 2 |
Hyperplasia, Focal | |
Acinar Cell, Hyperplasia, Focal | 1 1 2 1 2 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Pharynx | + + |
Palate, Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 6| 6| 7| 7| 6| 6| 6| 6| 7| 5| 6|
DAY ON TEST | 2| 2| 4| 3| 4| 0| 3| 3| 3| 9| 3| 6| 8| 3| 8| 4| 3| 3| 2| 6| 9| 0| 3| 7| 8|
| 1| 6| 1| 6| 1| 3| 3| 6| 6| 6| 6| 6| 4| 6| 1| 1| 6| 6| 0| 6| 4| 8| 1| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.50% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 3 |
Ulcer | 3 |
Mucosa, Hyperplasia | 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 1 |
Atrophy | |
Congestion | 3 |
Focal Cellular Change | 1 |
Hemorrhage | |
Hyperplasia | |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | |
Pars Distalis, Focal Cellular Change | 2 2 |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 |
Follicle, Dilatation | 2 |
Follicular Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 6| 6| 7| 7| 6| 6| 6| 6| 7| 5| 6|
DAY ON TEST | 2| 2| 4| 3| 4| 0| 3| 3| 3| 9| 3| 6| 8| 3| 8| 4| 3| 3| 2| 6| 9| 0| 3| 7| 8|
| 1| 6| 1| 6| 1| 3| 3| 6| 6| 6| 6| 6| 4| 6| 1| 1| 6| 6| 0| 6| 4| 8| 1| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.50% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Degeneration, Cystic | 2 2 3 3 3 1 3 2 1 2 1 1 3 3 3 2 2 3 2 2 3 3|
Hyperplasia | 2 |
Inflammation, Chronic | 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 1 1 1 1 2 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 3 4 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Thrombosis | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + M + + + + + + +|
Congestion | 3 |
Edema | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | 2|
Fibrosis, Focal | 1 2 3 3 2 2 2 2 3 2 2 2 2 3 |
Hematopoietic Cell Proliferation | 3 |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 2 2 |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hyperkeratosis, Focal | 2 |
Inflammation, Chronic, Focal | |
Epidermis, Hyperplasia, Focal | 2 |
Prepuce, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 6| 6| 7| 7| 6| 6| 6| 6| 7| 5| 6|
DAY ON TEST | 2| 2| 4| 3| 4| 0| 3| 3| 3| 9| 3| 6| 8| 3| 8| 4| 3| 3| 2| 6| 9| 0| 3| 7| 8|
| 1| 6| 1| 6| 1| 3| 3| 6| 6| 6| 6| 6| 4| 6| 1| 1| 6| 6| 0| 6| 4| 8| 1| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.50% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Fibrosis | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage | 3 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 2 |
Hemorrhage, Focal | 1 1 |
Hyperplasia, Diffuse, Histiocytic | |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 1 2 |
Inflammation, Suppurative | 2 3 2 2 1 2 2 2 2|
Mucosa, Angiectasis, Focal | 2|
Mucosa, Hyperkeratosis, Focal | 2 |
Mucosa, Hyperplasia, Focal | 3 2 |
Mucosa, Metaplasia, Focal, Squamous | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | |
Cataract | 2 |
Synechia | 2 |
Cornea, Inflammation, Chronic | 2 |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 1 2 2 2 1 3 2 1 2 3 2 2 2 2 2 2 2 2 1 1 3 1 3|
Papilla, Degeneration | 1 1 1 1 2 2 2 2 2 1 1 1 2 1 2 3 2 2 3|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 6| 6| 7| 7| 6| 6| 6| 6| 7| 5| 6|
DAY ON TEST | 2| 2| 4| 3| 4| 0| 3| 3| 3| 9| 3| 6| 8| 3| 8| 4| 3| 3| 2| 6| 9| 0| 3| 7| 8|
| 1| 6| 1| 6| 1| 3| 3| 6| 6| 6| 6| 6| 4| 6| 1| 1| 6| 6| 0| 6| 4| 8| 1| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.50% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Papilla, Epithelium, Hyperplasia | 1 1 2 2 1 2 1 2 1 1 1 2|
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Urethra | + |
Bulbourethral Gland, Dilatation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 5| 6| 7| 7| 5| 6| 6| 5| 6| 6| 6| 7| 7| 4|
DAY ON TEST | 2| 6| 9| 9| 9| 7| 3| 8| 5| 9| 3| 9| 5| 3| 3| 3| 4| 2| 3| 0| 2| 0| 3| 3| 5|
| 2| 2| 7| 6| 7| 3| 6| 4| 6| 5| 7| 2| 4| 7| 7| 6| 5| 7| 6| 8| 1| 5| 7| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.50% | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 1 1 1 1 1 1 1|
Clear Cell Focus | |
Degeneration, Cystic | 2 1 1 2 2 2 |
Eosinophilic Focus | 1 2 |
Fatty Change | 2 3 3 1 3 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 2 2 2|
Infarct | |
Infiltration Cellular, Mixed Cell | 2 2 2 2|
Inflammation, Focal | 2 1 |
Mixed Cell Focus | |
Necrosis, Focal | 2 |
Thrombosis | |
Bile Duct, Hyperplasia | 3 2 3 1 2 3 2 3 2 3 3 2 2 3 1 2 3 3 3 1 4 |
Centrilobular, Atrophy | 2 3 3 3 3 2 2 3 3 2 3 3 2 2 |
Centrilobular, Necrosis | |
Hepatocyte, Hyperplasia, Multifocal | 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Accessory Spleen | |
Inflammation, Chronic | 2 |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 2 2 1 2 3 2 2 1 3 1 1 1 1|
Hyperplasia, Focal | |
Acinar Cell, Hyperplasia, Focal | 1 1 2 1 2 1|
Duct, Dilatation | 2 2 |
__________________________________________________________________________|
Pharynx | + + |
Palate, Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 5| 6| 7| 7| 5| 6| 6| 5| 6| 6| 6| 7| 7| 4|
DAY ON TEST | 2| 6| 9| 9| 9| 7| 3| 8| 5| 9| 3| 9| 5| 3| 3| 3| 4| 2| 3| 0| 2| 0| 3| 3| 5|
| 2| 2| 7| 6| 7| 3| 6| 4| 6| 5| 7| 2| 4| 7| 7| 6| 5| 7| 6| 8| 1| 5| 7| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.50% | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 3 |
Ulcer | 2 3 |
Mucosa, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + + + + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Atrophy | 4 |
Congestion | |
Focal Cellular Change | 2 1 1 1 2 |
Hemorrhage | 1 |
Hyperplasia | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 1 |
Pars Distalis, Focal Cellular Change | 2 2 |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2|
C-Cell, Hyperplasia | 1 1 1 2 |
Follicle, Dilatation | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 5| 6| 7| 7| 5| 6| 6| 5| 6| 6| 6| 7| 7| 4|
DAY ON TEST | 2| 6| 9| 9| 9| 7| 3| 8| 5| 9| 3| 9| 5| 3| 3| 3| 4| 2| 3| 0| 2| 0| 3| 3| 5|
| 2| 2| 7| 6| 7| 3| 6| 4| 6| 5| 7| 2| 4| 7| 7| 6| 5| 7| 6| 8| 1| 5| 7| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.50% | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Degeneration, Cystic | 3 2 2 3 2 2 2 2 3 2 3 2 3 1 2 2 3 3 3 3 3 2 3 3 2|
Hyperplasia | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 1 2 2 1 1 1 2 1 1 2 2 1 3 2 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 4 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 2 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 3|
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Thrombosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | |
Hyperplasia | 4 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | 1 |
Fibrosis, Focal | 2 2 2 2 2 2 3 2 |
Hematopoietic Cell Proliferation | 2 3|
Necrosis, Focal | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + I + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + + + + + M + + + + + +|
Dilatation | 2 2 2 2 2 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Hyperkeratosis, Focal | 3 2 |
Inflammation, Chronic, Focal | 2 |
Epidermis, Hyperplasia, Focal | 3 |
Prepuce, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 5| 6| 7| 7| 5| 6| 6| 5| 6| 6| 6| 7| 7| 4|
DAY ON TEST | 2| 6| 9| 9| 9| 7| 3| 8| 5| 9| 3| 9| 5| 3| 3| 3| 4| 2| 3| 0| 2| 0| 3| 3| 5|
| 2| 2| 7| 6| 7| 3| 6| 4| 6| 5| 7| 2| 4| 7| 7| 6| 5| 7| 6| 8| 1| 5| 7| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.50% | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 1 |
Hemorrhage | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | |
Hyperplasia, Diffuse, Histiocytic | 3 |
Inflammation, Chronic, Focal | 2 |
Alveolar Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 |
Inflammation, Suppurative | 2 2 3 1 3 2 2 |
Mucosa, Angiectasis, Focal | |
Mucosa, Hyperkeratosis, Focal | |
Mucosa, Hyperplasia, Focal | |
Mucosa, Metaplasia, Focal, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
Cataract | 3 |
Synechia | |
Cornea, Inflammation, Chronic | |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Zymbal's Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 1 2 1 1 3 2 2 2 2 2 1 2 2 1 1 2 1 2 2 2 2 2 1|
Papilla, Degeneration | 1 1 1 1 2 1 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 5| 6| 7| 7| 5| 6| 6| 5| 6| 6| 6| 7| 7| 4|
DAY ON TEST | 2| 6| 9| 9| 9| 7| 3| 8| 5| 9| 3| 9| 5| 3| 3| 3| 4| 2| 3| 0| 2| 0| 3| 3| 5|
| 2| 2| 7| 6| 7| 3| 6| 4| 6| 5| 7| 2| 4| 7| 7| 6| 5| 7| 6| 8| 1| 5| 7| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.50% | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Papilla, Epithelium, Hyperplasia | 1 2 1 1 1 1 2 1 1 1 1 1 2 |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.50% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | 1 | 3 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Parasite Metazoan | 2 1 | 5 1.4|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Basophilic Focus | 1 1 1 | 16 1.0|
Clear Cell Focus | | 1 1.0|
Degeneration, Cystic | 1 | 11 1.6|
Eosinophilic Focus | | 2 1.5|
Fatty Change | 2 2 1 1 1 2 1 2 | 16 1.9|
Focal Cellular Change | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | 1 | 4 1.8|
Infarct | | 1 3.0|
Infiltration Cellular, Mixed Cell | 2 1 | 7 1.9|
Inflammation, Focal | 1 1 1 | 6 1.2|
Mixed Cell Focus | | 1 2.0|
Necrosis, Focal | | 2 2.0|
Thrombosis | | 1 1.0|
Bile Duct, Hyperplasia | 2 1 1 1 2 1 2 | 51 2.2|
Centrilobular, Atrophy | 2 | 31 2.7|
Centrilobular, Necrosis | | 1 1.0|
Hepatocyte, Hyperplasia, Multifocal | | 10 1.9|
__________________________________________________________________________|____________|
Mesentery | + + + | 21 |
Accessory Spleen | 1 | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Fat, Necrosis | | 6 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy, Focal | 1 1 | 27 1.7|
Hyperplasia, Focal | 2 | 1 2.0|
Acinar Cell, Hyperplasia, Focal | | 12 1.3|
Duct, Dilatation | | 2 2.0|
__________________________________________________________________________|____________|
Pharynx | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.50% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Palate, Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
Inflammation, Chronic | 3 | 4 2.8|
Ulcer | 3 | 4 2.8|
Mucosa, Hyperplasia | 3 | 6 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tongue | | 5 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Thrombosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 4 1.3|
Atrophy | | 1 4.0|
Congestion | | 1 3.0|
Focal Cellular Change | | 6 1.3|
Hemorrhage | | 1 1.0|
Hyperplasia | | 1 2.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 2 1 | 13 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 58 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Angiectasis | | 2 2.0|
Cyst | | 1 1.0|
Pars Distalis, Focal Cellular Change | | 4 2.0|
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia | | 5 1.2|
Follicle, Dilatation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.50% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Granuloma Sperm | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 2 2 2 2 2 2 2 2 2 2 | 57 2.3|
Hyperplasia | | 2 2.5|
Inflammation, Chronic | 2 | 3 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 2 2 1 1 2 1 | 34 1.6|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Hyperplasia | 1 2 1 1 1 | 9 1.1|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Germinal Epithelium, Degeneration | | 7 3.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | 2 | 6 2.5|
Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + | 36 |
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Congestion | | 1 3.0|
Edema | | 1 2.0|
Hyperplasia | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + | 25 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Developmental Malformation | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.50% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis, Focal | | 22 2.2|
Hematopoietic Cell Proliferation | | 3 2.7|
Necrosis, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + | 57 |
Dilatation | | 11 2.0|
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Hemorrhage, Focal | | 1 2.0|
Hyperkeratosis, Focal | | 3 2.3|
Inflammation, Chronic, Focal | | 1 2.0|
Epidermis, Hyperplasia, Focal | | 2 2.5|
Prepuce, Inflammation, Chronic | | 1 2.0|
Subcutaneous Tissue, Fibrosis | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 2 | 4 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 2 2.0|
Hemorrhage | | 2 2.5|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 3 2.3|
Hemorrhage, Focal | | 2 1.0|
Hyperplasia, Diffuse, Histiocytic | | 1 3.0|
Inflammation, Chronic, Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 5 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 1 | 6 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.50% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 1 | 17 2.0|
Mucosa, Angiectasis, Focal | | 1 2.0|
Mucosa, Hyperkeratosis, Focal | | 1 2.0|
Mucosa, Hyperplasia, Focal | | 2 2.5|
Mucosa, Metaplasia, Focal, Squamous | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Atrophy | | 1 4.0|
Cataract | | 2 2.5|
Synechia | | 1 2.0|
Cornea, Inflammation, Chronic | | 1 2.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy | 1 2 2 2 2 2 2 2 1 2 | 60 1.8|
Papilla, Degeneration | 2 3 | 32 1.6|
Papilla, Epithelium, Hyperplasia | 2 | 26 1.3|
Renal Tubule, Epithelium, | | |
Hyperplasia, Focal | | 2 1.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Bulbourethral Gland, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 3| 7| 4| 5| 6| 6| 6| 6| 4| 6| 6| 5| 5| 6| 5| 6| 5| 3| 6| 5| 6| 7| 4| 5|
DAY ON TEST | 4| 9| 1| 9| 6| 8| 5| 8| 9| 5| 7| 6| 1| 4| 9| 2| 1| 0| 8| 5| 7| 2| 3| 7| 7|
| 3| 3| 1| 5| 8| 7| 8| 2| 0| 1| 0| 2| 6| 1| 7| 3| 9| 9| 1| 4| 6| 0| 3| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.00% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
Thrombosis | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + A + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 1 |
Basophilic Focus | 2 1 2 1 2 1 |
Clear Cell Focus | |
Congestion, Focal | 2 |
Cyst | 3 |
Degeneration, Cystic | 2 1 |
Eosinophilic Focus | |
Fatty Change | 3 3 1 1 1 3 2 |
Hematopoietic Cell Proliferation | 2 2 2 |
Hepatodiaphragmatic Nodule | 2 |
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Focal | 1 |
Mixed Cell Focus | |
Necrosis, Focal | 2 2 2 |
Thrombosis | 2 |
Bile Duct, Dilatation, Focal | |
Bile Duct, Hyperplasia | 3 3 1 2 4 3 2 1 1 1 1 2 1 2 2 2 2 3 2|
Centrilobular, Atrophy | 2 3 4 2 3 2 3 4 4 3 2 2 2|
Centrilobular, Necrosis | 2 3 2 |
Hepatocyte, Hyperplasia, Multifocal | 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + |
Inflammation, Chronic | 2 |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + A + + + + A + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 1 2 1 1 1 2 2 |
Acinar Cell, Hyperplasia, Focal | 1 2 1 2 1 1 1|
__________________________________________________________________________|
Pharynx | + + + |
Palate, Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 3| 7| 4| 5| 6| 6| 6| 6| 4| 6| 6| 5| 5| 6| 5| 6| 5| 3| 6| 5| 6| 7| 4| 5|
DAY ON TEST | 4| 9| 1| 9| 6| 8| 5| 8| 9| 5| 7| 6| 1| 4| 9| 2| 1| 0| 8| 5| 7| 2| 3| 7| 7|
| 3| 3| 1| 5| 8| 7| 8| 2| 0| 1| 0| 2| 6| 1| 7| 3| 9| 9| 1| 4| 6| 0| 3| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.00% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + A + + + + + + + + + + + + + + + + + +|
Erosion | 2 1 |
Inflammation, Chronic | 2 |
Pigmentation, Focal | |
__________________________________________________________________________|
Tongue | + + + + + + +|
Epithelium, Hyperplasia, Focal | 3 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 |
Mineralization, Focal | 3 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + M + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 2 1 |
Angiectasis | 2 |
Congestion | 2|
Focal Cellular Change | 2 1 1 2 1 3 1 2 2 2|
Hematopoietic Cell Proliferation | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 |
Hemorrhage | |
Pars Distalis, Focal Cellular Change | 1 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 1 |
Follicle, Dilatation | 2 3 2 |
Follicular Cell, Hyperplasia | 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 3| 7| 4| 5| 6| 6| 6| 6| 4| 6| 6| 5| 5| 6| 5| 6| 5| 3| 6| 5| 6| 7| 4| 5|
DAY ON TEST | 4| 9| 1| 9| 6| 8| 5| 8| 9| 5| 7| 6| 1| 4| 9| 2| 1| 0| 8| 5| 7| 2| 3| 7| 7|
| 3| 3| 1| 5| 8| 7| 8| 2| 0| 1| 0| 2| 6| 1| 7| 3| 9| 9| 1| 4| 6| 0| 3| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.00% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + + |
Scrotal, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Hyperplasia | |
__________________________________________________________________________|
Epididymis | + + + + M + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 4 3 2 3 3 1 2 2 3 2 2 2 2 3 1 2 2 2 1 2 2 2 2 2|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 4 2 2 3 2 2 2 2 2 1 2 3 2 2 1|
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hyperplasia | 2 1 1 1 2|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
Germinal Epithelium, Degeneration | 3 2 3 |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 2 3 2 3 3 3 |
Metaplasia, Osseous | 2 3 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Inguinal, Hyperplasia | |
Mediastinal, Hemorrhage | 3 1 2 |
Mediastinal, Hyperplasia | 3 |
Mediastinal, Pigmentation | 3 |
Pancreatic, Edema | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 3| 7| 4| 5| 6| 6| 6| 6| 4| 6| 6| 5| 5| 6| 5| 6| 5| 3| 6| 5| 6| 7| 4| 5|
DAY ON TEST | 4| 9| 1| 9| 6| 8| 5| 8| 9| 5| 7| 6| 1| 4| 9| 2| 1| 0| 8| 5| 7| 2| 3| 7| 7|
| 3| 3| 1| 5| 8| 7| 8| 2| 0| 1| 0| 2| 6| 1| 7| 3| 9| 9| 1| 4| 6| 0| 3| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.00% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | |
Developmental Malformation | 3 |
Fibrosis, Focal | 3 3 2 3 2 2 2 2 2 3 2 2 2 2 3|
Hematopoietic Cell Proliferation | 2 3 3 2 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + M + + + + M +|
Angiectasis | 2 |
Dilatation | 2 2 |
Hemorrhage | |
Hyperplasia | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis, Focal | 2 |
Inflammation, Chronic, Focal | 3 2 2 |
Ulcer | 3 |
Epidermis, Hyperplasia, Focal | 2 |
Sebaceous Gland, Hyperplasia, Focal | |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 2 |
Subcutaneous Tissue, Fat, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 1 |
__________________________________________________________________________|
Skeletal Muscle | + + + |
Hemorrhage, Focal | 3 |
Inflammation, Chronic | 3 |
Necrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hemorrhage | 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 3| 7| 4| 5| 6| 6| 6| 6| 4| 6| 6| 5| 5| 6| 5| 6| 5| 3| 6| 5| 6| 7| 4| 5|
DAY ON TEST | 4| 9| 1| 9| 6| 8| 5| 8| 9| 5| 7| 6| 1| 4| 9| 2| 1| 0| 8| 5| 7| 2| 3| 7| 7|
| 3| 3| 1| 5| 8| 7| 8| 2| 0| 1| 0| 2| 6| 1| 7| 3| 9| 9| 1| 4| 6| 0| 3| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.00% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyperplasia, Focal, Histiocytic | |
Alveolar Epithelium, Hyperplasia | 1 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 1 2 1 3 |
Inflammation, Suppurative | 1 2 2 3 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + |
Dilatation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 3 |
Cyst | 2 |
Inflammation, Chronic, Suppurative | 4 |
Nephropathy | 3 1 2 3 1 2 3 1 2 3 1 2 1 2 1 1 1 1 3 2 2 2 2|
Cortex, Medulla, Mineralization, | |
Focal | |
Papilla, Degeneration | 3 4 4 3 1 1 2 1 1 2 2 2 2 3 2 |
Papilla, Mineralization, Focal | 1 |
Papilla, Epithelium, Hyperplasia | 1 2 2 3 2 1 2 3 2 2 3 2 2 2 2 2 3 2 2 2 2 2|
Pelvis, Dilatation | 1 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 3 1 2 |
__________________________________________________________________________|
Urethra | + |
Bulbourethral Gland, Dilatation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 5| 5| 5| 5| 7| 5| 6| 5| 5| 6| 6| 6| 5| 5| 5| 5| 5| 4| 7| 6|
DAY ON TEST | 4| 1| 9| 2| 1| 9| 6| 1| 4| 0| 7| 6| 6| 7| 4| 1| 0| 4| 8| 6| 5| 7| 3| 3| 8|
| 4| 9| 5| 3| 9| 8| 7| 3| 2| 9| 4| 2| 7| 7| 7| 0| 4| 9| 5| 7| 6| 6| 2| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.00% | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 1 2|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 1 1 1 |
Clear Cell Focus | 1 |
Congestion, Focal | |
Cyst | 3 |
Degeneration, Cystic | 2 2 2 |
Eosinophilic Focus | 1 |
Fatty Change | 1 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 3 1 2 |
Infiltration Cellular, Mixed Cell | 2 2 1 3 2 2 |
Inflammation, Focal | 1 |
Mixed Cell Focus | X |
Necrosis, Focal | |
Thrombosis | |
Bile Duct, Dilatation, Focal | 2 |
Bile Duct, Hyperplasia | 2 2 1 3 2 2 1 2 2 3 2 1 3 3 2 2 3 3|
Centrilobular, Atrophy | 2 2 3 4 4 2 2 2 3|
Centrilobular, Necrosis | 3 |
Hepatocyte, Hyperplasia, Multifocal | 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + + + + + +|
Inflammation, Chronic | 1 |
Fat, Necrosis | 1 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 2 2 2 1 2 2 2 2 2 1 3 2 2|
Acinar Cell, Hyperplasia, Focal | 3 2 1 3 3 1 3 |
__________________________________________________________________________|
Pharynx | + |
Palate, Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 5| 5| 5| 5| 7| 5| 6| 5| 5| 6| 6| 6| 5| 5| 5| 5| 5| 4| 7| 6|
DAY ON TEST | 4| 1| 9| 2| 1| 9| 6| 1| 4| 0| 7| 6| 6| 7| 4| 1| 0| 4| 8| 6| 5| 7| 3| 3| 8|
| 4| 9| 5| 3| 9| 8| 7| 3| 2| 9| 4| 2| 7| 7| 7| 0| 4| 9| 5| 7| 6| 6| 2| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.00% | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | |
Pigmentation, Focal | 2 |
__________________________________________________________________________|
Tongue | + + + + |
Epithelium, Hyperplasia, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Mesenteric Artery, Inflammation, | |
Chronic | 3 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Mineralization, Focal | |
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | |
Congestion | 2|
Focal Cellular Change | 2 1 1 2 |
Hematopoietic Cell Proliferation | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Angiectasis | 2 2 |
Cyst | 2 |
Hemorrhage | |
Pars Distalis, Focal Cellular Change | 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 1 |
C-Cell, Hyperplasia | 2 1 1 |
Follicle, Dilatation | |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 5| 5| 5| 5| 7| 5| 6| 5| 5| 6| 6| 6| 5| 5| 5| 5| 5| 4| 7| 6|
DAY ON TEST | 4| 1| 9| 2| 1| 9| 6| 1| 4| 0| 7| 6| 6| 7| 4| 1| 0| 4| 8| 6| 5| 7| 3| 3| 8|
| 4| 9| 5| 3| 9| 8| 7| 3| 2| 9| 4| 2| 7| 7| 7| 0| 4| 9| 5| 7| 6| 6| 2| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.00% | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Scrotal, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 2 4 2 3 3 2 3 3 2 2 2 2 3 2 3 2 2 3 3 2 3 3 2|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 1 1 2 1 1 3 1 1 1 2 3 3 1 1|
Epithelium, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia | 1 2 1 1 2 1 3 1 1 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 |
Germinal Epithelium, Degeneration | 3 4 2 |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 2 3 3 2 |
Metaplasia, Osseous | 4 |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Inguinal, Hyperplasia | 3 |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia | 2 |
Mediastinal, Pigmentation | |
Pancreatic, Edema | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 3 3 3 |
Hyperplasia | 2 4 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 5| 5| 5| 5| 7| 5| 6| 5| 5| 6| 6| 6| 5| 5| 5| 5| 5| 4| 7| 6|
DAY ON TEST | 4| 1| 9| 2| 1| 9| 6| 1| 4| 0| 7| 6| 6| 7| 4| 1| 0| 4| 8| 6| 5| 7| 3| 3| 8|
| 4| 9| 5| 3| 9| 8| 7| 3| 2| 9| 4| 2| 7| 7| 7| 0| 4| 9| 5| 7| 6| 6| 2| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.00% | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | 2 |
Developmental Malformation | |
Fibrosis, Focal | 2 2 3 2 3 2 2 1|
Hematopoietic Cell Proliferation | 3 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + I + + + + + + M + + + + + + +|
Angiectasis | |
Dilatation | 2 2 |
Hemorrhage | 2 |
Hyperplasia | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis, Focal | 2 |
Inflammation, Chronic, Focal | |
Ulcer | |
Epidermis, Hyperplasia, Focal | 2 |
Sebaceous Gland, Hyperplasia, Focal | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 1 |
Subcutaneous Tissue, Fat, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage, Focal | |
Inflammation, Chronic | |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 4 |
Hemorrhage | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 5| 5| 5| 5| 7| 5| 6| 5| 5| 6| 6| 6| 5| 5| 5| 5| 5| 4| 7| 6|
DAY ON TEST | 4| 1| 9| 2| 1| 9| 6| 1| 4| 0| 7| 6| 6| 7| 4| 1| 0| 4| 8| 6| 5| 7| 3| 3| 8|
| 4| 9| 5| 3| 9| 8| 7| 3| 2| 9| 4| 2| 7| 7| 7| 0| 4| 9| 5| 7| 6| 6| 2| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.00% | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyperplasia, Focal, Histiocytic | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Suppurative | 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + |
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 3 3 |
Cyst | |
Inflammation, Chronic, Suppurative | |
Nephropathy | 2 3 2 1 2 1 1 2 2 2 2 1 1 1 1 2 2 2 1 1 1 2 2 2 1|
Cortex, Medulla, Mineralization, | |
Focal | 3 |
Papilla, Degeneration | 1 3 2 2 1 2 1 2 2 3 2 2 3 1|
Papilla, Mineralization, Focal | |
Papilla, Epithelium, Hyperplasia | 2 2 2 2 1 2 1 1 1 2 1 2 2 2 2 1 3 2 3 2 1|
Pelvis, Dilatation | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 4| 4| 1| 4| 4| 4| | |
DAY ON TEST | 8| 7| 0| 2| 5| 5| 4| 5| 5| 5| | |
| 6| 0| 8| 0| 6| 6| 9| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.00% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
Parasite Metazoan | 1 | 8 1.3|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
Mucosa, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 3 2.0|
Basophilic Focus | | 10 1.3|
Clear Cell Focus | | 1 1.0|
Congestion, Focal | | 1 2.0|
Cyst | | 2 3.0|
Degeneration, Cystic | | 5 1.8|
Eosinophilic Focus | 1 | 2 1.0|
Fatty Change | 3 3 2 1 1 1 | 15 1.9|
Hematopoietic Cell Proliferation | | 3 2.0|
Hepatodiaphragmatic Nodule | | 4 2.0|
Infiltration Cellular, Mixed Cell | | 8 2.0|
Inflammation, Focal | 2 1 | 4 1.3|
Mixed Cell Focus | | 1 |
Necrosis, Focal | 2 | 4 2.0|
Thrombosis | | 1 2.0|
Bile Duct, Dilatation, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 2 2 1 1 | 43 2.0|
Centrilobular, Atrophy | 3 4 3 3 | 26 2.8|
Centrilobular, Necrosis | | 4 2.5|
Hepatocyte, Hyperplasia, Multifocal | 3 | 8 2.1|
__________________________________________________________________________|____________|
Mesentery | + + | 23 |
Inflammation, Chronic | | 2 1.5|
Fat, Necrosis | 3 | 5 1.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Atrophy, Focal | 1 2 | 26 1.7|
Acinar Cell, Hyperplasia, Focal | | 14 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 4| 4| 1| 4| 4| 4| | |
DAY ON TEST | 8| 7| 0| 2| 5| 5| 4| 5| 5| 5| | |
| 6| 0| 8| 0| 6| 6| 9| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.00% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pharynx | + | 5 |
Palate, Epithelium, Hyperplasia, | | |
Focal | 2 | 3 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Chronic | 3 2 3 | 3 2.7|
Ulcer | 2 2 | 2 2.0|
Mucosa, Hyperplasia | 2 1 3 | 6 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Erosion | 2 | 4 1.8|
Inflammation, Chronic | 2 | 2 2.0|
Pigmentation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + | 13 |
Epithelium, Hyperplasia, Focal | | 4 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 2 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 1 3.0|
Mineralization, Focal | | 1 3.0|
Thrombosis | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Accessory Adrenal Cortical Nodule | 1 | 4 1.3|
Angiectasis | | 1 2.0|
Congestion | | 2 2.0|
Focal Cellular Change | | 14 1.6|
Hematopoietic Cell Proliferation | | 1 2.0|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | | 5 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 58 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 4| 4| 1| 4| 4| 4| | |
DAY ON TEST | 8| 7| 0| 2| 5| 5| 4| 5| 5| 5| | |
| 6| 0| 8| 0| 6| 6| 9| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.00% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Angiectasis | 2 | 3 2.0|
Cyst | | 2 2.5|
Hemorrhage | 3 | 1 3.0|
Pars Distalis, Focal Cellular Change | 2 1 | 5 1.6|
Pars Distalis, Hyperplasia, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | | 3 1.7|
C-Cell, Hyperplasia | 2 | 5 1.4|
Follicle, Dilatation | | 3 2.3|
Follicular Cell, Hyperplasia | | 5 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 6 |
Scrotal, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
Granuloma Sperm | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 2 2 2 3 2 2 2 1 1 2 | 60 2.3|
Inflammation, Chronic | 3 | 3 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 1 2 1 2 1 3 1 2 | 40 1.8|
Epithelium, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | | 1 3.0|
Hyperplasia | 1 2 | 17 1.4|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Mineralization, Focal | | 1 2.0|
Germinal Epithelium, Degeneration | | 6 2.8|
Interstitial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | 3 2 | 16 2.6|
Metaplasia, Osseous | 2 | 4 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 4| 4| 1| 4| 4| 4| | |
DAY ON TEST | 8| 7| 0| 2| 5| 5| 4| 5| 5| 5| | |
| 6| 0| 8| 0| 6| 6| 9| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.00% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Myelofibrosis | 3 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 27 |
Inguinal, Hyperplasia | | 1 3.0|
Mediastinal, Hemorrhage | | 3 2.0|
Mediastinal, Hyperplasia | | 2 2.5|
Mediastinal, Pigmentation | | 1 3.0|
Pancreatic, Edema | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Hyperplasia | | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Edema | | 4 3.0|
Hyperplasia | | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + | 23 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Congestion | | 1 2.0|
Developmental Malformation | | 1 3.0|
Fibrosis, Focal | 2 | 24 2.3|
Hematopoietic Cell Proliferation | | 8 2.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + | 57 |
Congestion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M + + + + + + + | 53 |
Angiectasis | | 1 2.0|
Dilatation | | 4 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Cyst Epithelial Inclusion | X | 1 |
Hyperkeratosis, Focal | | 2 2.0|
Inflammation, Chronic, Focal | | 3 2.3|
Ulcer | | 1 3.0|
Epidermis, Hyperplasia, Focal | | 2 2.0|
Sebaceous Gland, Hyperplasia, Focal | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | | 2 1.5|
Subcutaneous Tissue, Fat, Necrosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 4| 4| 1| 4| 4| 4| | |
DAY ON TEST | 8| 7| 0| 2| 5| 5| 4| 5| 5| 5| | |
| 6| 0| 8| 0| 6| 6| 9| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.00% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 3 | 5 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 4 |
Hemorrhage, Focal | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Necrosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 3 2.7|
Hemorrhage | | 2 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 2.0|
Hemorrhage, Focal | | 1 2.0|
Hyperplasia, Focal, Histiocytic | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 7 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 2 | 5 1.8|
Inflammation, Suppurative | 3 | 11 2.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Glands, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 5 |
Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Atrophy, Focal | 3 | 6 3.0|
Cyst | | 1 2.0|
Inflammation, Chronic, Suppurative | | 1 4.0|
Nephropathy | 2 1 1 2 2 1 1 1 2 2 | 58 1.7|
Cortex, Medulla, Mineralization, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 4| 4| 1| 4| 4| 4| | |
DAY ON TEST | 8| 7| 0| 2| 5| 5| 4| 5| 5| 5| | |
| 6| 0| 8| 0| 6| 6| 9| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.00% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Focal | | 1 3.0|
Papilla, Degeneration | 2 1 2 1 | 33 2.0|
Papilla, Mineralization, Focal | 3 | 2 2.0|
Papilla, Epithelium, Hyperplasia | 1 2 2 2 2 1 2 1 4 | 52 1.9|
Pelvis, Dilatation | | 1 1.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Bulbourethral Gland, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Inflammation, Chronic | 4 | 1 4.0|
Transitional Epithelium, Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 5| 7| 5| 2| 4| 5| 5| 6| 5| 6| 5| 3| 4| 5| 7|
DAY ON TEST | 5| 6| 7| 5| 8| 1| 9| 1| 7| 5| 0| 0| 8| 2| 3| 1| 0| 2| 2| 5| 1| 6| 2| 9| 2|
| 1| 0| 1| 9| 5| 6| 2| 9| 5| 3| 7| 4| 6| 2| 2| 1| 7| 0| 2| 9| 6| 6| 4| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.00% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 3 |
Inflammation, Chronic, Focal | 3 |
Metaplasia, Focal, Osseous | |
Mucosa, Hyperplasia, Cystic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | 1 3 1|
Congestion, Focal | 2 |
Degeneration, Cystic | 1 1 2 1 |
Developmental Malformation | 2 |
Eosinophilic Focus | 4 |
Fatty Change | 3 1 2 3 3 3 1 2 2 |
Focal Cellular Change | 2 2 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 2 |
Hepatodiaphragmatic Nodule, Multiple | 3 |
Infiltration Cellular, Mixed Cell | 2 2 2 3 2|
Inflammation, Focal | 2 1 |
Mixed Cell Focus | |
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 2 2 2 2 3 1 1 1 3 1 1 2 1 3 3 2 1 1 2|
Centrilobular, Atrophy | 4 2 3 3 2 2 2 4 2 2 2 3 2 |
Centrilobular, Congestion | |
Centrilobular, Necrosis | 2 |
Hepatocyte, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + |
Inflammation, Chronic | |
Fat, Necrosis | 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 3 |
Atrophy, Focal | 2 1 2 2 1 2 2|
Acinar Cell, Focal Cellular Change | |
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 5| 7| 5| 2| 4| 5| 5| 6| 5| 6| 5| 3| 4| 5| 7|
DAY ON TEST | 5| 6| 7| 5| 8| 1| 9| 1| 7| 5| 0| 0| 8| 2| 3| 1| 0| 2| 2| 5| 1| 6| 2| 9| 2|
| 1| 0| 1| 9| 5| 6| 2| 9| 5| 3| 7| 4| 6| 2| 2| 1| 7| 0| 2| 9| 6| 6| 4| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.00% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinar Cell, Hyperplasia, Focal | 3 3 2 1 1 3|
Duct, Dilatation | 2 |
__________________________________________________________________________|
Pharynx | + + + + + + |
Palate, Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4 |
Inflammation, Chronic | 3 2 3 |
Ulcer | 2 3 |
Mucosa, Hyperplasia | 1 1 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Pigmentation, Focal | 2 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Tongue | + + + + +|
Epithelium, Hyperplasia, Focal | 2 3 |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 2 |
Angiectasis | |
Congestion | |
Focal Cellular Change | 1 2 2 |
Hematopoietic Cell Proliferation | 2 |
Necrosis, Focal | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + M + + M +|
Cyst | 3 2 |
Pars Distalis, Focal Cellular Change | 1 2 |
Pars Distalis, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 112
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 5| 7| 5| 2| 4| 5| 5| 6| 5| 6| 5| 3| 4| 5| 7|
DAY ON TEST | 5| 6| 7| 5| 8| 1| 9| 1| 7| 5| 0| 0| 8| 2| 3| 1| 0| 2| 2| 5| 1| 6| 2| 9| 2|
| 1| 0| 1| 9| 5| 6| 2| 9| 5| 3| 7| 4| 6| 2| 2| 1| 7| 0| 2| 9| 6| 6| 4| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.00% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 1 |
Follicle, Dilatation | 2 1 2 2 2 2 |
Follicular Cell, Hyperplasia | 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Hyperplasia | 1 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 2 3 2 2 3 3 2 2 3 2 2 3 3 2 3 2 2 3 3 2 3 3|
Inflammation, Chronic | 3 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 2 2 1 3 1 1 2 3 2 2 1 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia | 1 1 1 1 1 2 1 1 1 2 2 1|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 3 2 3 2 3 3 3 2|
Myelofibrosis | 2 1 |
Necrosis, Focal | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + |
Deep Cervical, Hyperplasia | 3 |
Mediastinal, Edema | |
Mediastinal, Hemorrhage | 3 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | 2 |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hyperplasia | 3 3 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 2 3 3 2 3 3 2 3 3 2|
_____________________________________________________________________________________________________________________|
Page 113
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 5| 7| 5| 2| 4| 5| 5| 6| 5| 6| 5| 3| 4| 5| 7|
DAY ON TEST | 5| 6| 7| 5| 8| 1| 9| 1| 7| 5| 0| 0| 8| 2| 3| 1| 0| 2| 2| 5| 1| 6| 2| 9| 2|
| 1| 0| 1| 9| 5| 6| 2| 9| 5| 3| 7| 4| 6| 2| 2| 1| 7| 0| 2| 9| 6| 6| 4| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.00% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 4 3 3 3 2 3 3 2|
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + M M + + + + + + M + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + M + + + + + M + M + + + M + + + + + +|
Dilatation | 3 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 3 |
Hyperkeratosis, Focal | |
Inflammation, Chronic, Focal | 3 |
Epidermis, Hyperplasia, Focal | 2 |
Hair Follicle, Cyst | 3 |
Sebaceous Gland, Hyperplasia, Focal | 2 |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 2 2 |
Adventitia, Calvarium, Proliferation | |
Connective Tissue | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Inflammation, Chronic, Focal | 1 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 1 3 1 1 2 2 |
Peribronchial, Infiltration Cellular,| |
Lymphocyte | 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 3 3 2|
Inflammation, Suppurative | 1 2 3 3 2|
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 3 |
Respiratory Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 114
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 5| 7| 5| 2| 4| 5| 5| 6| 5| 6| 5| 3| 4| 5| 7|
DAY ON TEST | 5| 6| 7| 5| 8| 1| 9| 1| 7| 5| 0| 0| 8| 2| 3| 1| 0| 2| 2| 5| 1| 6| 2| 9| 2|
| 1| 0| 1| 9| 5| 6| 2| 9| 5| 3| 7| 4| 6| 2| 2| 1| 7| 0| 2| 9| 6| 6| 4| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.00% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Sclera, Mineralization, Focal | 2 |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + |
Dilatation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | 3 |
Nephropathy | 1 1 1 1 1 2 1 1 2 3 1 2 2 1 1 1 2 1 1 1 1 2 2 2|
Papilla, Degeneration | 1 2 1 1 2|
Papilla, Epithelium, Hyperplasia | 1 1 1 1 |
Pelvis, Dilatation | 3 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic | 1 |
Transitional Epithelium, Hyperplasia | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 115
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 5| 4| 4| 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 4| 4| 5| 5| 3| 7| 6| 5| 4| 5|
DAY ON TEST | 4| 2| 3| 0| 1| 1| 1| 2| 1| 7| 3| 7| 6| 0| 5| 9| 1| 2| 1| 8| 0| 2| 1| 7| 7|
| 7| 0| 2| 2| 9| 9| 9| 2| 0| 6| 7| 7| 3| 5| 4| 0| 0| 1| 3| 8| 4| 5| 3| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
2.00% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Parasite Metazoan | 2 1|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Diverticulum | 3|
Inflammation, Chronic, Focal | |
Metaplasia, Focal, Osseous | 2|
Mucosa, Hyperplasia, Cystic | 3|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Chronic, Focal | 4 |
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 3 1 3 1 1 1 1 |
Congestion, Focal | |
Degeneration, Cystic | 2 2 |
Developmental Malformation | |
Eosinophilic Focus | 1 4 |
Fatty Change | 1 1 2 3 4 2 3 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 2 2 1 |
Hepatodiaphragmatic Nodule | |
Hepatodiaphragmatic Nodule, Multiple | |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 3 |
Inflammation, Focal | 1 1 1 1 1 |
Mixed Cell Focus | |
Necrosis, Focal | 2 |
Bile Duct, Hyperplasia | 2 1 2 3 3 2 2 1 2 2 2 2 3 2 2 1 3 2 1|
Centrilobular, Atrophy | 2 3 2 3 3 2 3 2 4 2 2 |
Centrilobular, Congestion | 2 |
Centrilobular, Necrosis | |
Hepatocyte, Hyperplasia, Multifocal | 2 3 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Fat, Necrosis | 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +|
Atrophy, Diffuse | |
Atrophy, Focal | 1 1 2 2 1 1 2 1 2 1 1 |
Acinar Cell, Focal Cellular Change | |
_____________________________________________________________________________________________________________________|
Page 116
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 5| 4| 4| 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 4| 4| 5| 5| 3| 7| 6| 5| 4| 5|
DAY ON TEST | 4| 2| 3| 0| 1| 1| 1| 2| 1| 7| 3| 7| 6| 0| 5| 9| 1| 2| 1| 8| 0| 2| 1| 7| 7|
| 7| 0| 2| 2| 9| 9| 9| 2| 0| 6| 7| 7| 3| 5| 4| 0| 0| 1| 3| 8| 4| 5| 3| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
2.00% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinar Cell, Hyperplasia, Focal | 1 2 2 1 3 2 3 4 3 2 1 2 2 2 1|
Duct, Dilatation | 2 |
__________________________________________________________________________|
Pharynx | + + |
Palate, Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + I + + + + + +|
Erosion | |
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 1 |
Pigmentation, Focal | 1 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Tongue | + + + + |
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 3 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 1 1 1|
Angiectasis | 2 |
Congestion | 2 |
Focal Cellular Change | 1 3 2|
Hematopoietic Cell Proliferation | |
Necrosis, Focal | |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 |
Pars Distalis, Focal Cellular Change | 1 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 117
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 5| 4| 4| 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 4| 4| 5| 5| 3| 7| 6| 5| 4| 5|
DAY ON TEST | 4| 2| 3| 0| 1| 1| 1| 2| 1| 7| 3| 7| 6| 0| 5| 9| 1| 2| 1| 8| 0| 2| 1| 7| 7|
| 7| 0| 2| 2| 9| 9| 9| 2| 0| 6| 7| 7| 3| 5| 4| 0| 0| 1| 3| 8| 4| 5| 3| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
2.00% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 2 1 1 1 1 1|
Follicle, Dilatation | 1 3 |
Follicular Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Hyperplasia | 1 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 2 2 2 3 2 3 2 1 3 3 2 2 2 2 3 2 2 4 3 3 3 2|
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 1 1 2 1 1 1 2 3 2 2 2 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hyperplasia | 1 1 2 1 1 2 1 1 1 1 1 2 3 2 1|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 4 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 3 3 2 3 |
Myelofibrosis | |
Necrosis, Focal | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Deep Cervical, Hyperplasia | |
Mediastinal, Edema | 2 2 |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | 3 |
Mediastinal, Pigmentation | 3 3 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia | 2 2 3 4 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 3|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 1 3 3 3 2 2 3 1 3 2 2 3 3 |
_____________________________________________________________________________________________________________________|
Page 118
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 5| 4| 4| 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 4| 4| 5| 5| 3| 7| 6| 5| 4| 5|
DAY ON TEST | 4| 2| 3| 0| 1| 1| 1| 2| 1| 7| 3| 7| 6| 0| 5| 9| 1| 2| 1| 8| 0| 2| 1| 7| 7|
| 7| 0| 2| 2| 9| 9| 9| 2| 0| 6| 7| 7| 3| 5| 4| 0| 0| 1| 3| 8| 4| 5| 3| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
2.00% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 3 3 3 2 3 2 |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + + + + + + M + + + + + M + + + + + + + + +|
Dilatation | 1 1 1 |
Hyperplasia | 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + M + + + + + + + + +|
Cyst Epithelial Inclusion | 3 |
Hyperkeratosis, Focal | 2 3 |
Inflammation, Chronic, Focal | 4 3 |
Epidermis, Hyperplasia, Focal | 2 2 |
Hair Follicle, Cyst | |
Sebaceous Gland, Hyperplasia, Focal | |
Subcutaneous Tissue, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 2 1 1 |
Adventitia, Calvarium, Proliferation | |
Connective Tissue | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 1 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Inflammation, Chronic, Focal | |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 2 2 2 2 1 1|
Peribronchial, Infiltration Cellular,| |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 1 |
Inflammation, Suppurative | 2 2 2 2 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Respiratory Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 119
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
_____________________________________________________________________________________________________________________
| 6| 5| 4| 4| 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 4| 4| 5| 5| 3| 7| 6| 5| 4| 5|
DAY ON TEST | 4| 2| 3| 0| 1| 1| 1| 2| 1| 7| 3| 7| 6| 0| 5| 9| 1| 2| 1| 8| 0| 2| 1| 7| 7|
| 7| 0| 2| 2| 9| 9| 9| 2| 0| 6| 7| 7| 3| 5| 4| 0| 0| 1| 3| 8| 4| 5| 3| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
2.00% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Sclera, Mineralization, Focal | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + |
Dilatation | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + + +|
Cyst | 2 |
Hydronephrosis | |
Nephropathy | 2 2 1 1 2 2 2 2 2 1 2 2 1 2 1 1 3 2 1 1 3 2 2 1|
Papilla, Degeneration | 1 1 1 2 1 1 1 |
Papilla, Epithelium, Hyperplasia | 1 1 1 1 2 1 1 1 1 2 2 1|
Pelvis, Dilatation | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 2 |
Transitional Epithelium, Hyperplasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 120
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 4| 3| 5| 4| 7| 5| 5| 6| 5| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 3| 9| 9| 2| 0| 3| 7| 2| 2| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 9| 6| 2| 5| 3| 0| 2| 1| 7| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.00% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 69 |
Parasite Metazoan | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 69 |
Parasite Metazoan | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 69 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 69 |
Diverticulum | | 2 3.0|
Inflammation, Chronic, Focal | | 1 3.0|
Metaplasia, Focal, Osseous | | 1 2.0|
Mucosa, Hyperplasia, Cystic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 69 |
Inflammation, Chronic, Focal | 3 | 2 3.5|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | 1 | 3 1.3|
Basophilic Focus | 2 1 | 12 1.6|
Congestion, Focal | | 1 2.0|
Degeneration, Cystic | 1 | 7 1.4|
Developmental Malformation | | 1 2.0|
Eosinophilic Focus | 3 2 | 5 2.8|
Fatty Change | 2 2 1 | 19 2.2|
Focal Cellular Change | | 2 2.0|
Hematopoietic Cell Proliferation | | 4 1.8|
Hepatodiaphragmatic Nodule | 2 2 2 2 | 5 2.0|
Hepatodiaphragmatic Nodule, Multiple | | 1 3.0|
Infiltration Cellular, Mixed Cell | 2 | 13 2.2|
Inflammation, Focal | 1 1 1 | 10 1.1|
Mixed Cell Focus | 3 | 1 3.0|
Necrosis, Focal | | 2 1.5|
Bile Duct, Hyperplasia | 2 1 1 3 3 1 | 44 1.9|
Centrilobular, Atrophy | 3 1 4 3 | 28 2.6|
Centrilobular, Congestion | | 1 2.0|
Centrilobular, Necrosis | | 1 2.0|
Hepatocyte, Hyperplasia, Multifocal | 2 | 4 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 30 |
Inflammation, Chronic | 2 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 121
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 4| 3| 5| 4| 7| 5| 5| 6| 5| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 3| 9| 9| 2| 0| 3| 7| 2| 2| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 9| 6| 2| 5| 3| 0| 2| 1| 7| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.00% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fat, Necrosis | 3 | 7 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 |
Atrophy, Diffuse | | 1 3.0|
Atrophy, Focal | 1 1 2 1 | 22 1.5|
Acinar Cell, Focal Cellular Change | 2 | 1 2.0|
Acinar Cell, Hyperplasia, Focal | 1 2 2 2 3 1 | 27 2.0|
Duct, Dilatation | | 2 2.0|
__________________________________________________________________________|____________|
Pharynx | + + | 10 |
Palate, Epithelium, Hyperplasia, | | |
Focal | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 69 |
Erosion | | 1 4.0|
Inflammation, Chronic | | 3 2.7|
Ulcer | | 2 2.5|
Mucosa, Hyperplasia | 1 | 6 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Erosion | | 4 1.5|
Pigmentation, Focal | | 2 1.5|
Mucosa, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Tongue | | 9 |
Epithelium, Hyperplasia, Focal | | 3 2.3|
__________________________________________________________________________|____________|
Tooth | | 2 |
Incisor, Dysplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Thrombosis | | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Accessory Adrenal Cortical Nodule | 1 2 2 | 11 1.5|
Angiectasis | | 1 2.0|
Congestion | | 1 2.0|
Focal Cellular Change | | 6 1.8|
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 122
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 4| 3| 5| 4| 7| 5| 5| 6| 5| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 3| 9| 9| 2| 0| 3| 7| 2| 2| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 9| 6| 2| 5| 3| 0| 2| 1| 7| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.00% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 1 | 9 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + | 68 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 67 |
Cyst | 2 | 6 2.2|
Pars Distalis, Focal Cellular Change | 2 | 6 1.7|
Pars Distalis, Hyperplasia, Focal | | 5 1.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
C-Cell, Hyperplasia | 1 | 15 1.3|
Follicle, Dilatation | 2 | 9 1.9|
Follicular Cell, Hyperplasia | | 6 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 8 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 3 |
Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Degeneration, Cystic | 3 2 3 3 2 2 3 2 3 2 2 2 2 2 2 2 | 64 2.4|
Inflammation, Chronic | 2 4 2 2 3 | 8 2.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Suppurative | 1 1 1 1 3 2 2 | 36 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 |
Dilatation | | 1 3.0|
Hyperplasia | 1 2 1 1 2 1 | 33 1.3|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
Germinal Epithelium, Degeneration | | 4 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Hypercellularity | 4 2 3 | 18 2.7|
Myelofibrosis | | 2 1.5|
Necrosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 31 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 123
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 4| 3| 5| 4| 7| 5| 5| 6| 5| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 3| 9| 9| 2| 0| 3| 7| 2| 2| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 9| 6| 2| 5| 3| 0| 2| 1| 7| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.00% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Deep Cervical, Hyperplasia | | 1 3.0|
Mediastinal, Edema | | 2 2.0|
Mediastinal, Hemorrhage | 2 | 4 2.5|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Hyperplasia | | 2 2.5|
Mediastinal, Pigmentation | | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 69 |
Edema | | 1 3.0|
Hyperplasia | 3 | 10 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 70 |
Edema | 4 | 3 3.3|
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 28 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Fibrosis, Focal | 2 2 2 | 28 2.4|
Hematopoietic Cell Proliferation | 3 3 4 | 17 2.9|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + | 67 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + I + + + + + + + + + + + | 60 |
Dilatation | | 4 1.5|
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 69 |
Cyst Epithelial Inclusion | | 2 3.0|
Hyperkeratosis, Focal | | 2 2.5|
Inflammation, Chronic, Focal | | 3 3.3|
Epidermis, Hyperplasia, Focal | | 3 2.0|
Hair Follicle, Cyst | | 1 3.0|
Sebaceous Gland, Hyperplasia, Focal | | 1 2.0|
Subcutaneous Tissue, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperostosis | 2 2 | 11 1.8|
Adventitia, Calvarium, Proliferation | | |
Connective Tissue | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 124
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 4| 3| 5| 4| 7| 5| 5| 6| 5| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 3| 9| 9| 2| 0| 3| 7| 2| 2| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 9| 6| 2| 5| 3| 0| 2| 1| 7| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.00% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Compression | 1 | 3 1.7|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemorrhage, Focal | | 1 2.0|
Inflammation, Chronic, Focal | | 1 1.0|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 2 | 14 1.6|
Peribronchial, Infiltration Cellular,| | |
Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Fungus | | 5 2.2|
Inflammation, Suppurative | 2 | 11 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 3.0|
Respiratory Epithelium, Hyperplasia, | | |
Focal | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Sclera, Mineralization, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 15 |
Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 69 |
Cyst | | 1 2.0|
Hydronephrosis | | 1 3.0|
Nephropathy | 2 2 2 1 2 1 2 2 1 2 1 1 1 | 61 1.6|
Papilla, Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 | 24 1.1|
Papilla, Epithelium, Hyperplasia | 1 1 1 1 1 | 21 1.1|
Pelvis, Dilatation | | 1 3.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 3 | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 125
NTP Experiment-Test: 05103-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL Date: 04/18/97
Route: DOSED FEED Time: 09:27:44
__________________________________________________________________________________________________________________________________
| 4| 3| 5| 4| 7| 5| 5| 6| 5| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 3| 9| 9| 2| 0| 3| 7| 2| 2| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 9| 6| 2| 5| 3| 0| 2| 1| 7| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.00% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 69 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | | 2 1.5|
Transitional Epithelium, Hyperplasia | 2 2 2 1 2 2 1 2 2 2 2 | 20 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 126
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