TDMS Study 05106-03 Pathology Tables
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
Facility: Hazleton, Maryland
Chemical CAS #: 84-66-2
Lock Date: 03/16/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 3| 3| 6| 9| 6| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 0| 0| 0| 1| 7| 6| 6| 6| 3| 1| 2| 7| 7| 7| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MICROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + I + + + + A A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + A A + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + A A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | |
Hepatocholangiocarcinoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Extra Adrenal Tissue, Lymphoma | |
Malignant Lymphocytic | |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + I + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 3| 3| 6| 9| 6| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 0| 0| 0| 1| 7| 6| 6| 6| 3| 1| 2| 7| 7| 7| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MICROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
Granulosa Cell Tumor Malignant | X |
Teratoma Malignant | |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp | X |
Sarcoma Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + I + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + I + + + M + + + + + + M + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 3| 3| 6| 9| 6| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 0| 0| 0| 1| 7| 6| 6| 6| 3| 1| 2| 7| 7| 7| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MICROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abdominal, Mast Cell Tumor Benign | X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, | |
Hepatocholangiocarcinoma, | |
Metastatic, Liver | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Mammary Gland | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Teratoma Malignant, Metastatic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Ureter | |
Leukemia Lymphocytic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 3| 3| 6| 9| 6| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 0| 0| 0| 1| 7| 6| 6| 6| 3| 1| 2| 7| 7| 7| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MICROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Lymphocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 2| 2| 3| 2| 2| 6| 6| 6| 6| 6| 0| 0| 0| 4| 0| 0| 6| 6| 6| 6| 5| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MICROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | |
Hepatocholangiocarcinoma | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + I + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Extra Adrenal Tissue, Lymphoma | |
Malignant Lymphocytic | X |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 2| 2| 3| 2| 2| 6| 6| 6| 6| 6| 0| 0| 0| 4| 0| 0| 6| 6| 6| 6| 5| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MICROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X X |
Granulosa Cell Tumor Malignant | |
Teratoma Malignant | X |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | X |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp | X X |
Sarcoma Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Lymphoma Malignant Mixed| X X |
Pancreatic, Lymphoma Malignant Mixed | X X X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + I + + I + + + M + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + I + + + + + + M + + + + I + M + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 2| 2| 3| 2| 2| 6| 6| 6| 6| 6| 0| 0| 0| 4| 0| 0| 6| 6| 6| 6| 5| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MICROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abdominal, Mast Cell Tumor Benign | |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, | |
Hepatocholangiocarcinoma, | |
Metastatic, Liver | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Mammary Gland | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Teratoma Malignant, Metastatic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Ureter | + |
Leukemia Lymphocytic | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 2| 2| 3| 2| 2| 6| 6| 6| 6| 6| 0| 0| 0| 4| 0| 0| 6| 6| 6| 6| 5| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MICROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Lymphocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| | |
| 2| 2| 2| 2| 2| 8| 8| 5| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MICROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hemangioma | | 1 |
Hepatocellular Carcinoma | X | 4 |
Hepatocellular Adenoma | | 6 |
Hepatocellular Adenoma, Multiple | X | 1 |
Hepatocholangiocarcinoma | | 1 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Adenoma | | 2 |
Extra Adrenal Tissue, Lymphoma | | |
Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 48 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Pheochromocytoma Benign | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| | |
| 2| 2| 2| 2| 2| 8| 8| 5| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MICROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Adenoma | X X | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + M | 59 |
Cystadenoma | X | 3 |
Granulosa Cell Tumor Malignant | | 1 |
Teratoma Malignant | | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Polyp | | 3 |
Sarcoma Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + | 7 |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Pancreatic, Lymphoma Malignant Mixed | | 3 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 56 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| | |
| 2| 2| 2| 2| 2| 8| 8| 5| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MICROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + M | 51 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Abdominal, Mast Cell Tumor Benign | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, | | |
Hepatocholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Carcinoma, Metastatic, Mammary Gland | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 2 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
Teratoma Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| | |
| 2| 2| 2| 2| 2| 8| 8| 5| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MICROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Ureter | | 1 |
Leukemia Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Lymphocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 5| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 6| 6| 7| 3| 3| 3| 3| 3| 1| 3| 3| 3| 0|
| 1| 5| 0| 1| 1| 1| 1| 1| 0| 1| 0| 0| 3| 8| 3| 1| 1| 1| 1| 1| 8| 6| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
7.5 MICR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A A + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + A|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A A + + + + + + + + + + A|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Pericardium, Lymphoma Malignant | |
Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + +|
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 5| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 6| 6| 7| 3| 3| 3| 3| 3| 1| 3| 3| 3| 0|
| 1| 5| 0| 1| 1| 1| 1| 1| 0| 1| 0| 0| 3| 8| 3| 1| 1| 1| 1| 1| 8| 6| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
7.5 MICR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + +|
Cystadenoma | |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + +|
Polyp, Multiple | X |
Cervix, Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | |
Sarcoma, Metastatic, Tissue NOS | |
Axillary, Sarcoma, Metastatic, | |
Tissue NOS | |
Bronchial, Lymphoma Malignant Mixed | |
Hemal, Lymphoma Malignant Mixed | |
Iliac, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + M|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 5| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 6| 6| 7| 3| 3| 3| 3| 3| 1| 3| 3| 3| 0|
| 1| 5| 0| 1| 1| 1| 1| 1| 0| 1| 0| 0| 3| 8| 3| 1| 1| 1| 1| 1| 8| 6| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
7.5 MICR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + M + + + + I|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X|
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | X|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Fibrosarcoma | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 5| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 6| 6| 7| 3| 3| 3| 3| 3| 1| 3| 3| 3| 0|
| 1| 5| 0| 1| 1| 1| 1| 1| 0| 1| 0| 0| 3| 8| 3| 1| 1| 1| 1| 1| 8| 6| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
7.5 MICR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Ureter | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 6| 8| 3| 3| 3|
| 4| 2| 2| 2| 2| 7| 7| 7| 7| 7| 8| 8| 5| 8| 8| 0| 0| 0| 0| 0| 0| 1| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
7.5 MICR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + A + + + + + M + + + M + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + M + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + A + + + + + + + + + + + A + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + A + + + + + + + + + + + A + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + A + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pericardium, Lymphoma Malignant | |
Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + I|
__________________________________________________________________________|
Pituitary Gland | + + + + I + + + + + + + + + + I + + + + I + + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 6| 8| 3| 3| 3|
| 4| 2| 2| 2| 2| 7| 7| 7| 7| 7| 8| 8| 5| 8| 8| 0| 0| 0| 0| 0| 0| 1| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
7.5 MICR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | X X X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X X X X |
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp, Multiple | |
Cervix, Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + |
Sarcoma, Metastatic, Tissue NOS | X |
Axillary, Sarcoma, Metastatic, | |
Tissue NOS | X |
Bronchial, Lymphoma Malignant Mixed | |
Hemal, Lymphoma Malignant Mixed | |
Iliac, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Histiocytic Sarcoma | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + I I + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + M I + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 6| 8| 3| 3| 3|
| 4| 2| 2| 2| 2| 7| 7| 7| 7| 7| 8| 8| 5| 8| 8| 0| 0| 0| 0| 0| 0| 1| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
7.5 MICR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | I + + + + + + + + + M + + + + + M + + + I + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + M M + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + M + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Fibrosarcoma | X |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 6| 8| 3| 3| 3|
| 4| 2| 2| 2| 2| 7| 7| 7| 7| 7| 8| 8| 5| 8| 8| 0| 0| 0| 0| 0| 0| 1| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
7.5 MICR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Ureter | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| | |
| 7| 7| 8| 7| 2| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
7.5 MICR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + M + + + | 41 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + | 45 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + | 44 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + | 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 55 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | | 5 |
Hepatocellular Adenoma | X X | 10 |
Hepatocellular Adenoma, Multiple | | 2 |
Histiocytic Sarcoma | | 3 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 51 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 51 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 51 |
Squamous Cell Carcinoma | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 51 |
Pericardium, Lymphoma Malignant | | |
Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 51 |
Capsule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 42 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| | |
| 7| 7| 8| 7| 2| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
7.5 MICR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 48 |
Pars Distalis, Adenoma | X X | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 51 |
Follicular Cell, Adenoma | X | 5 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 51 |
Cystadenoma | | 4 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 51 |
Polyp, Multiple | | 1 |
Cervix, Histiocytic Sarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 51 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 7 |
Sarcoma, Metastatic, Tissue NOS | | 1 |
Axillary, Sarcoma, Metastatic, | | |
Tissue NOS | | 1 |
Bronchial, Lymphoma Malignant Mixed | X X | 2 |
Hemal, Lymphoma Malignant Mixed | X | 1 |
Iliac, Lymphoma Malignant Mixed | X X | 2 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
Mediastinal, Histiocytic Sarcoma | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| X X X | 4 |
Pancreatic, Lymphoma Malignant Mixed | X X | 2 |
Renal, Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + | 47 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| | |
| 7| 7| 8| 7| 2| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
7.5 MICR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + | 45 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | X X X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 51 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X X X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Thymus | + I M + M + + + + M | 40 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + | 46 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 51 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 51 |
Alveolar/Bronchiolar Adenoma | X | 6 |
Alveolar/Bronchiolar Carcinoma | X | 3 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 4 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| | |
| 7| 7| 8| 7| 2| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
7.5 MICR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Fibrosarcoma | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 51 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Ureter | + | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 55 |
Histiocytic Sarcoma | | 3 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | X X X X | 8 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 5| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 8| 3| 3| 2| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3|
| 0| 1| 1| 0| 1| 1| 1| 0| 0| 0| 4| 3| 8| 8| 1| 0| 0| 0| 3| 0| 6| 6| 6| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
Leiomyoma | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 5| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 8| 3| 3| 2| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3|
| 0| 1| 1| 0| 1| 1| 1| 0| 0| 0| 4| 3| 8| 8| 1| 0| 0| 0| 3| 0| 6| 6| 6| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + +|
Cystadenoma | X |
Granulosa Cell Tumor Malignant | X |
Luteoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Polyp | |
Cervix, Histiocytic Sarcoma | |
Cervix, Leiomyosarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Axillary, Lymphoma Malignant Mixed | |
Bronchial, Lymphoma Malignant Mixed | |
Deep Cervical, Lymphoma Malignant | |
Mixed | |
Hemal, Lymphoma Malignant Mixed | |
Iliac, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Pancreatic, Lymphoma Malignant Mixed | |
Prefemoral, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + I + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | + M + M + + + + + + + + + M +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 5| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 8| 3| 3| 2| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3|
| 0| 1| 1| 0| 1| 1| 1| 0| 0| 0| 4| 3| 8| 8| 1| 0| 0| 0| 3| 0| 6| 6| 6| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Harderian Gland | |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Fibrosarcoma | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
Adenocarcinoma | |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 1| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 9| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3|
| 2| 6| 2| 5| 2| 8| 2| 8| 8| 8| 2| 2| 2| 3| 3| 6| 3| 8| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
15 MICRO | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X X|
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 1| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 9| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3|
| 2| 6| 2| 5| 2| 8| 2| 8| 8| 8| 2| 2| 2| 3| 3| 6| 3| 8| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
15 MICRO | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +|
Cystadenoma | X |
Granulosa Cell Tumor Malignant | |
Luteoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hemangiosarcoma | |
Polyp | X |
Cervix, Histiocytic Sarcoma | X |
Cervix, Leiomyosarcoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Axillary, Lymphoma Malignant Mixed | X |
Bronchial, Lymphoma Malignant Mixed | X |
Deep Cervical, Lymphoma Malignant | |
Mixed | X |
Hemal, Lymphoma Malignant Mixed | X |
Iliac, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant Mixed| X |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | |
Pancreatic, Lymphoma Malignant Mixed | X |
Prefemoral, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + I + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + I + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + I + M + M + + + + + + + + + + M + + + + M + M M|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 1| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 9| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3|
| 2| 6| 2| 5| 2| 8| 2| 8| 8| 8| 2| 2| 2| 3| 3| 6| 3| 8| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
15 MICRO | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Harderian Gland | X |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Fibrosarcoma | X |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
Adenocarcinoma | X |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| | |
| 0| 0| 0| 0| 0| 2| 2| 2| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
15 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + M + + + M + + A A | 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A | 48 |
Leiomyoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 50 |
Adenocarcinoma | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A | 49 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 53 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X | 6 |
Hepatocellular Adenoma | X X X X X X | 13 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 50 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + + + + + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| | |
| 0| 0| 0| 0| 0| 2| 2| 2| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
15 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Hemangiosarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 49 |
Cystadenoma | | 2 |
Granulosa Cell Tumor Malignant | | 1 |
Luteoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 49 |
Hemangiosarcoma | | 1 |
Polyp | | 1 |
Cervix, Histiocytic Sarcoma | | 1 |
Cervix, Leiomyosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
Axillary, Lymphoma Malignant Mixed | | 1 |
Bronchial, Lymphoma Malignant Mixed | | 1 |
Deep Cervical, Lymphoma Malignant | | |
Mixed | | 1 |
Hemal, Lymphoma Malignant Mixed | | 1 |
Iliac, Lymphoma Malignant Mixed | | 2 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Lymphoma Malignant Mixed| X | 2 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Pancreatic, Lymphoma Malignant Mixed | X | 2 |
Prefemoral, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + | 47 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| | |
| 0| 0| 0| 0| 0| 2| 2| 2| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
15 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X X | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Hemangiosarcoma | X X | 3 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Thymus | M M + M M + + + + M | 35 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Adenocarcinoma, Metastatic, | | |
Harderian Gland | | 1 |
Alveolar/Bronchiolar Adenoma | | 4 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 3 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Fibrosarcoma | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| | |
| 0| 0| 0| 0| 0| 2| 2| 2| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
15 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
Adenocarcinoma | | 1 |
Adenoma | X X | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 53 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3|
| 1| 1| 0| 1| 1| 0| 0| 0| 1| 0| 6| 6| 2| 6| 6| 2| 2| 2| 2| 2| 3| 3| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
30 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + A + M + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + A + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Extra Adrenal Tissue, Lymphoma | |
Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3|
| 1| 1| 0| 1| 1| 0| 0| 0| 1| 0| 6| 6| 2| 6| 6| 2| 2| 2| 2| 2| 3| 3| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
30 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + M + + + + + + + + + + + + +|
Cystadenoma | |
Hemangiosarcoma | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + + + |
Lymphoma Malignant Lymphocytic | X |
Axillary, Lymphoma Malignant | |
Lymphocytic | X |
Axillary, Lymphoma Malignant Mixed | |
Bronchial, Lymphoma Malignant Mixed | |
Deep Cervical, Lymphoma Malignant | |
Mixed | |
Hemal, Lymphoma Malignant Mixed | |
Iliac, Lymphoma Malignant Lymphocytic| X |
Iliac, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X X |
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| |
Renal, Lymphoma Malignant Lymphocytic| X X |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + I + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3|
| 1| 1| 0| 1| 1| 0| 0| 0| 1| 0| 6| 6| 2| 6| 6| 2| 2| 2| 2| 2| 3| 3| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
30 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hemangiosarcoma, Multiple | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X |
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3|
| 1| 1| 0| 1| 1| 0| 0| 0| 1| 0| 6| 6| 2| 6| 6| 2| 2| 2| 2| 2| 3| 3| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
30 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 9| 3| 2| 3| 4| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 7| 7| 7| 1| 7| 3| 8| 1| 8| 5| 0| 0| 0| 0| 2| 5| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
30 MICRO | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + A + + + + + + + + + + A + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | |
Hepatocellular Carcinoma | |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X X|
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + I + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Extra Adrenal Tissue, Lymphoma | |
Malignant Mixed | X X |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 9| 3| 2| 3| 4| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 7| 7| 7| 1| 7| 3| 8| 1| 8| 5| 0| 0| 0| 0| 2| 5| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
30 MICRO | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X X |
Hemangiosarcoma | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + |
Lymphoma Malignant Lymphocytic | |
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Axillary, Lymphoma Malignant Mixed | X X |
Bronchial, Lymphoma Malignant Mixed | X |
Deep Cervical, Lymphoma Malignant | |
Mixed | X |
Hemal, Lymphoma Malignant Mixed | X |
Iliac, Lymphoma Malignant Lymphocytic| |
Iliac, Lymphoma Malignant Mixed | X X |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Inguinal, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X X |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + A + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 9| 3| 2| 3| 4| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 7| 7| 7| 1| 7| 3| 8| 1| 8| 5| 0| 0| 0| 0| 2| 5| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
30 MICRO | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hemangiosarcoma, Multiple | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X X |
__________________________________________________________________________|
Thymus | M + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + M A + + M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Lymphoma Malignant Lymphocytic | |
Squamous Cell Carcinoma | X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 9| 3| 2| 3| 4| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 7| 7| 7| 1| 7| 3| 8| 1| 8| 5| 0| 0| 0| 0| 2| 5| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
30 MICRO | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X X |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 6| 2| 4| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 4| 4| 5| 3| 3| 3| 3| 3| 4| | |
| 1| 8| 7| 6| 1| 1| 1| 1| 1| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
30 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 55 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
Hepatocellular Carcinoma | X | 3 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X | 10 |
Hepatocellular Adenoma, Multiple | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Mesentery | | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Squamous Cell Papilloma | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Adenoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Extra Adrenal Tissue, Lymphoma | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 6| 2| 4| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 4| 4| 5| 3| 3| 3| 3| 3| 4| | |
| 1| 8| 7| 6| 1| 1| 1| 1| 1| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
30 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 48 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Cystadenoma | | 2 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 8 |
Lymphoma Malignant Lymphocytic | | 1 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Axillary, Lymphoma Malignant Mixed | | 2 |
Bronchial, Lymphoma Malignant Mixed | | 1 |
Deep Cervical, Lymphoma Malignant | | |
Mixed | | 1 |
Hemal, Lymphoma Malignant Mixed | | 1 |
Iliac, Lymphoma Malignant Lymphocytic| | 1 |
Iliac, Lymphoma Malignant Mixed | | 2 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Inguinal, Lymphoma Malignant Mixed | | 1 |
Lumbar, Lymphoma Malignant | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 6| 2| 4| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 4| 4| 5| 3| 3| 3| 3| 3| 4| | |
| 1| 8| 7| 6| 1| 1| 1| 1| 1| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
30 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Renal, Lymphoma Malignant Lymphocytic| | 2 |
Renal, Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + I + + + + + + | 57 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 2 |
Hemangiosarcoma, Multiple | X | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 5 |
__________________________________________________________________________|____________|
Thymus | + + + I + M + + + M | 55 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + + | 54 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Basal Cell Carcinoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Squamous Cell Carcinoma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Vertebra, Osteosarcoma | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 4 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 6| 2| 4| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 4| 4| 5| 3| 3| 3| 3| 3| 4| | |
| 1| 8| 7| 6| 1| 1| 1| 1| 1| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
30 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 4 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 0| 1| 1| 1| 1| 0| 0| 0| 0| 6| 0| 5| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MICROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + A + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + A + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma, Multiple | X |
Hemangiosarcoma, Multiple | |
Hepatocellular Carcinoma | X X|
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + I + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Lymphoma Malignant Lymphocytic | |
Capsule, Adenoma | X|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Lipoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 0| 1| 1| 1| 1| 0| 0| 0| 0| 6| 0| 5| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MICROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Sarcoma | X |
__________________________________________________________________________|
Penis | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Preputial Gland | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Iliac, Lymphoma Malignant Lymphocytic| |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | |
Renal, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + I + I + + + + + + + + + + + I|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hemangiosarcoma, Multiple | X X|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M M + M + + M M M M + + + + +|
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M + M + M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 0| 1| 1| 1| 1| 0| 0| 0| 0| 6| 0| 5| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MICROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hemangiosarcoma | X |
Lymphoma Malignant Lymphocytic | |
Control, Lymphoma Malignant | |
Lymphocytic | |
Site of Application-No Mass, | |
Lymphoma Malignant Lymphocytic | |
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Paraganglioma | |
Benign | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X|
Alveolar/Bronchiolar Carcinoma | X X X |
Hemangiosarcoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3|
| 2| 2| 2| 2| 0| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 2| 1| 2| 2| 2| 7| 7| 6| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MICROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + M + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma, Multiple | |
Hemangiosarcoma, Multiple | |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
Lymphoma Malignant Lymphocytic | |
Capsule, Adenoma | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Lipoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3|
| 2| 2| 2| 2| 0| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 2| 1| 2| 2| 2| 7| 7| 6| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MICROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Sarcoma | |
__________________________________________________________________________|
Penis | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Iliac, Lymphoma Malignant Lymphocytic| |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | |
Renal, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M I + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + I + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Hemangiosarcoma, Multiple | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Thymus | + M + + + M + M + + + + M M M + + + + + + + + M M|
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M M M M M M M M M M M M M M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3|
| 2| 2| 2| 2| 0| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 2| 1| 2| 2| 2| 7| 7| 6| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MICROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hemangiosarcoma | |
Lymphoma Malignant Lymphocytic | |
Control, Lymphoma Malignant | |
Lymphocytic | |
Site of Application-No Mass, | |
Lymphoma Malignant Lymphocytic | |
Subcutaneous Tissue, Hemangiosarcoma | |
Subcutaneous Tissue, Paraganglioma | |
Benign | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Hemangiosarcoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 0| 8| 0| 0| 0| 1| 1| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MICROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + | 57 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Adenoma, Multiple | | 1 |
Hemangiosarcoma, Multiple | X | 1 |
Hepatocellular Carcinoma | | 3 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X | 6 |
Hepatocellular Adenoma, Multiple | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Adenoma | | 6 |
Lymphoma Malignant Lymphocytic | X | 1 |
Capsule, Adenoma | | 3 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 0| 8| 0| 0| 0| 1| 1| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MICROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | X | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Penis | + | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Iliac, Lymphoma Malignant Lymphocytic| X | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Renal, Lymphoma Malignant Lymphocytic| X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + I + + + + + + + + | 53 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 0| 8| 0| 0| 0| 1| 1| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MICROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hemangiosarcoma | X | 4 |
Hemangiosarcoma, Multiple | | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + M + M M M + M M | 39 |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Control, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Site of Application-No Mass, | | |
Lymphoma Malignant Lymphocytic | X | 1 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
Subcutaneous Tissue, Paraganglioma | | |
Benign | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 6 |
Alveolar/Bronchiolar Carcinoma | X | 5 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 0| 8| 0| 0| 0| 1| 1| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MICROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 3| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 3| 3| 3| 3| 7| 3| 3| 3| 7| 9| 3| 9| 3| 3|
| 0| 0| 1| 0| 1| 0| 0| 1| 1| 1| 0| 7| 7| 7| 7| 8| 7| 7| 7| 6| 0| 8| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
7.5 MICR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | |
Hemangioma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + +|
Adenoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Gland | + + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + I + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 3| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 3| 3| 3| 3| 7| 3| 3| 3| 7| 9| 3| 9| 3| 3|
| 0| 0| 1| 0| 1| 0| 0| 1| 1| 1| 0| 7| 7| 7| 7| 8| 7| 7| 7| 6| 0| 8| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
7.5 MICR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Iliac, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant Mixed| X |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + M + + + M + + I +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 3| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 3| 3| 3| 3| 7| 3| 3| 3| 7| 9| 3| 9| 3| 3|
| 0| 0| 1| 0| 1| 0| 0| 1| 1| 1| 0| 7| 7| 7| 7| 8| 7| 7| 7| 6| 0| 8| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
7.5 MICR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 6| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 6| 6| 9| 6| 6| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
7.5 MICR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + M M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + |
Hemangioma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Capsule, Adenoma | X X |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Histiocytic Sarcoma, Metastatic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 6| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 6| 6| 9| 6| 6| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
7.5 MICR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
Iliac, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + I + M +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + M M + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M M M M + M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 6| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 6| 6| 9| 6| 6| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
7.5 MICR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 5| 7| | |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 2| 3| 9| 3| | |
| 6| 6| 5| 6| 6| 8| 7| 8| 0| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
7.5 MICR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 53 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma | X | 3 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X | 11 |
Hepatocellular Adenoma, Multiple | | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Hemangioma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 49 |
Adenoma | X | 3 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
Capsule, Adenoma | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland | | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + I + + + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 5| 7| | |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 2| 3| 9| 3| | |
| 6| 6| 5| 6| 6| 8| 7| 8| 0| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
7.5 MICR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Histiocytic Sarcoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 49 |
Interstitial Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Iliac, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 47 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Thymus | M + + + + M M + + M | 39 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 65
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 5| 7| | |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 2| 3| 9| 3| | |
| 6| 6| 5| 6| 6| 8| 7| 8| 0| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
7.5 MICR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
OLITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Histiocytic Sarcoma, Metastatic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | X | 5 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 53 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 66
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3|
| 0| 1| 0| 1| 0| 0| 0| 0| 0| 1| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
15 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Adrenal Gland | + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + A + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Lipoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3|
| 0| 1| 0| 1| 0| 0| 0| 0| 0| 1| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
15 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + I + M + + + + + + + + +|
Hemangiosarcoma | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
__________________________________________________________________________|
Thymus | + + M M + + + + + M + M I + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
Vertebra, Osteosarcoma | X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 6| 6| 6| 5| 6| 3| 7| 7| 7| 7| 6| 6| 6| 6| 6| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
15 MICRO | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X|
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + M + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Adrenal Gland | + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Lipoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 6| 6| 6| 5| 6| 3| 7| 7| 7| 7| 6| 6| 6| 6| 6| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
15 MICRO | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + M + + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X|
__________________________________________________________________________|
Thymus | + M + + + + + + M + I + + + + M + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M + M + M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 2| 4| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
15 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A M + + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 51 |
Hepatocellular Carcinoma | X X | 5 |
Hepatocellular Carcinoma, Multiple | X | 1 |
Hepatocellular Adenoma | X X | 7 |
Hepatocellular Adenoma, Multiple | | 3 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 49 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland | | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 49 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
Follicular Cell, Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 2| 4| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
15 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Interstitial Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + | 47 |
Hemangiosarcoma | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Hemangiosarcoma | X | 5 |
__________________________________________________________________________|____________|
Thymus | + + M + + + I I + + | 37 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M M M M M M | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
Vertebra, Osteosarcoma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | X X X | 6 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | X | 4 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 2| 4| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
15 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 73
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3|
| 1| 1| 1| 0| 0| 1| 1| 1| 0| 1| 6| 7| 7| 7| 8| 7| 7| 7| 7| 7| 1| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
30 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + A + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + A + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + A + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Carcinoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Gland | + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemangioma | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3|
| 1| 1| 1| 0| 0| 1| 1| 1| 0| 1| 6| 7| 7| 7| 8| 7| 7| 7| 7| 7| 1| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
30 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Iliac, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hemangiosarcoma, Multiple | |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + M + + + + M M M + + M I + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + M M + M + M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Diaphragm, Carcinoma, Metastatic, | |
Pancreas | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Liver | |
Carcinoma, Metastatic, Pancreas | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3|
| 1| 1| 1| 0| 0| 1| 1| 1| 0| 1| 6| 7| 7| 7| 8| 7| 7| 7| 7| 7| 1| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
30 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 7| 3| 3|
| 2| 2| 2| 2| 2| 1| 1| 1| 1| 1| 4| 8| 8| 8| 8| 2| 7| 2| 2| 2| 0| 0| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
30 MICRO | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + + + A + M M + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + A + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + A + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + A + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hemangiosarcoma, Multiple | |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X|
Hepatocellular Adenoma, Multiple | X X X |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Carcinoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Capsule, Adenoma | X X |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemangioma | X |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 7| 3| 3|
| 2| 2| 2| 2| 2| 1| 1| 1| 1| 1| 4| 8| 8| 8| 8| 2| 7| 2| 2| 2| 0| 0| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
30 MICRO | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
Iliac, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | X |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Thymus | + + + + M + + + + + M + I + M M I + + + + + M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M + M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Carcinoma, Metastatic, | |
Pancreas | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X X |
Carcinoma, Metastatic, Liver | X |
Carcinoma, Metastatic, Pancreas | X |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 7| 3| 3|
| 2| 2| 2| 2| 2| 1| 1| 1| 1| 1| 4| 8| 8| 8| 8| 2| 7| 2| 2| 2| 0| 0| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
30 MICRO | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + I + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
30 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + M + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 1 |
Hemangiosarcoma, Multiple | | 1 |
Hepatocellular Carcinoma | | 5 |
Hepatocellular Carcinoma, Multiple | | 3 |
Hepatocellular Adenoma | X X X | 10 |
Hepatocellular Adenoma, Multiple | | 4 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Adenoma | | 2 |
Capsule, Adenoma | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + I + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 80
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
30 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Hemangioma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Iliac, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 1 |
Hemangiosarcoma, Multiple | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Thymus | + M M M + + + M + + | 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Diaphragm, Carcinoma, Metastatic, | | |
Pancreas | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 81
NTP Experiment-Test: 05106-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: DERMAL,SOLUTION Time: 08:35:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
30 MICRO | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LITERS | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 6 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | | 3 |
Carcinoma, Metastatic, Liver | | 1 |
Carcinoma, Metastatic, Pancreas | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 4 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 82
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------