TDMS Study 05106-03 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
DIETHYLPHTHALATE
NTP Experiment-Test: 05106-03 Report: PEIRPT05
Study Type: CHRONIC Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:49
Facility: Hazleton, Maryland
Chemical CAS #: 84-66-2
Lock Date: 03/16/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 9 10 10
Early Deaths
Natural Death 5 8 7 5
Moribund Sacrifice 4 5 5 8
Accidently Killed 1
Survivors
Natural Death 1 1
Terminal Sacrifice 41 37 36 36
Missing 1
Animals Examined Microscopically 60 55 53 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (57) (41) (44) (55)
Intestine Large, Cecum (58) (45) (48) (60)
Leiomyoma 1 (2%)
Intestine Small, Duodenum (57) (45) (48) (58)
Intestine Small, Jejunum (58) (44) (50) (58)
Adenocarcinoma 1 (2%)
Intestine Small, Ileum (57) (44) (49) (57)
Liver (60) (55) (53) (60)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Hepatocellular Carcinoma 4 (7%) 5 (9%) 6 (11%) 3 (5%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 6 (10%) 10 (18%) 13 (25%) 10 (17%)
Hepatocellular Adenoma, Multiple 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Hepatocholangiocarcinoma 1 (2%)
Histiocytic Sarcoma 3 (5%) 1 (2%)
Pancreas (59) (51) (50) (59)
Salivary Glands (60) (51) (50) (60)
Stomach, Forestomach (60) (51) (50) (59)
Squamous Cell Carcinoma 2 (4%)
Squamous Cell Papilloma 1 (2%) 2 (3%)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (51) (50) (60)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (51) (50) (60)
Adenoma 2 (3%) 1 (2%) 1 (2%)
Capsule, Adenoma 1 (2%)
Adrenal Medulla (60) (51) (50) (60)
Pheochromocytoma Benign 4 (7%)
Islets, Pancreatic (60) (51) (50) (59)
Carcinoma 2 (3%)
Pituitary Gland (59) (48) (50) (59)
Pars Distalis, Adenoma 6 (10%) 4 (8%) 4 (8%) 1 (2%)
Thyroid Gland (60) (51) (50) (60)
Follicular Cell, Adenoma 1 (2%) 5 (10%) 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (2) (1)
Hemangiosarcoma 1 (100%) 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (59) (51) (49) (59)
Cystadenoma 3 (5%) 4 (8%) 2 (4%) 2 (3%)
Granulosa Cell Tumor Malignant 1 (2%) 1 (2%)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Luteoma 1 (2%)
Teratoma Malignant 1 (2%)
Uterus (60) (51) (49) (60)
Hemangiosarcoma 1 (2%)
Polyp 3 (5%) 1 (2%)
Polyp, Multiple 1 (2%)
Sarcoma Stromal 1 (2%)
Cervix, Histiocytic Sarcoma 2 (4%) 1 (2%)
Cervix, Leiomyosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (51) (50) (60)
Lymph Node (7) (7) (5) (8)
Sarcoma, Metastatic, Tissue NOS 1 (14%)
Axillary, Sarcoma, Metastatic, Tissue NOS 1 (14%)
Mediastinal, Histiocytic Sarcoma 1 (14%)
Lymph Node, Mandibular (56) (47) (47) (57)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (59) (45) (48) (60)
Histiocytic Sarcoma 1 (2%)
Spleen (60) (51) (50) (60)
Hemangiosarcoma 3 (6%) 2 (3%)
Hemangiosarcoma, Multiple 1 (2%)
Thymus (51) (40) (35) (55)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (46) (50) (54)
Carcinoma 1 (2%)
Skin (60) (51) (50) (60)
Basal Cell Carcinoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Abdominal, Mast Cell Tumor Benign 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 2 (4%) 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue,
Hepatocholangiocarcinoma, Metastatic,
Liver 1 (2%)
Subcutaneous Tissue, Sarcoma 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (51) (50) (60)
Vertebra, Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1) (1) (4)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (51) (50) (60)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (51) (50) (60)
Adenocarcinoma, Metastatic, Harderian Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 2 (3%) 6 (12%) 4 (8%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (3%) 3 (6%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (3%) 4 (8%) 3 (6%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Teratoma Malignant, Metastatic 1 (2%)
Nose (60) (50) (50) (60)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1)
Fibrosarcoma 1 (100%) 1 (100%)
Harderian Gland (1) (1) (5)
Adenocarcinoma 1 (20%)
Adenoma 1 (100%) 1 (100%) 4 (80%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (51) (50) (60)
Histiocytic Sarcoma 1 (2%)
Ureter (1) (1)
Urinary Bladder (59) (47) (49) (58)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(55) *(53) *(60)
Histiocytic Sarcoma 3 (5%) 1 (2%)
Leukemia Lymphocytic 1 (2%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 2 (3%) 3 (5%) 2 (4%) 2 (3%)
Lymphoma Malignant Mixed 5 (8%) 8 (15%) 5 (9%) 6 (10%)
Lymphoma Malignant Undifferentiated Cell 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 36 41 38 31
Total Primary Neoplasms 55 69 62 42
Total Animals with Benign Neoplasms 24 26 26 17
Total Benign Neoplasms 32 34 33 20
Total Animals with Malignant Neoplasms 18 27 23 20
Total Malignant Neoplasms 23 35 29 22
Total Animals with Metastatic Neoplasms 5 5 5 2
Total Metastatic Neoplasm 8 6 5 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Natural Death 5 4 2 6
Moribund Sacrifice 2 3 2 1
Accidently Killed 1
Survivors
Terminal Sacrifice 43 41 46 43
Missing 1
Animals Examined Microscopically 60 53 51 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (57) (49) (48) (56)
Intestine Small, Jejunum (57) (49) (48) (56)
Intestine Small, Ileum (57) (48) (48) (56)
Liver (60) (53) (51) (60)
Adenoma, Multiple 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%)
Hemangiosarcoma, Multiple 1 (2%) 1 (2%)
Hepatocellular Carcinoma 3 (5%) 3 (6%) 5 (10%) 5 (8%)
Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%) 1 (2%) 3 (5%)
Hepatocellular Adenoma 6 (10%) 11 (21%) 7 (14%) 10 (17%)
Hepatocellular Adenoma, Multiple 1 (2%) 2 (4%) 3 (6%) 4 (7%)
Histiocytic Sarcoma 1 (2%)
Mesentery (2) (2) (2)
Hemangioma 1 (50%)
Pancreas (60) (49) (50) (60)
Acinus, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (50) (50) (60)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (49) (49) (60)
Adenoma 6 (10%) 3 (6%) 2 (4%) 2 (3%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Capsule, Adenoma 3 (5%) 2 (4%) 2 (3%)
Adrenal Medulla (60) (50) (49) (60)
Pheochromocytoma Benign 1 (2%)
Pituitary Gland (58) (47) (48) (59)
Histiocytic Sarcoma, Metastatic 1 (2%)
Thyroid Gland (60) (50) (50) (60)
Follicular Cell, Adenoma 2 (3%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (3) (1) (2) (1)
Hemangioma 1 (100%)
Lipoma 1 (33%) 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (49) (50) (60)
Sarcoma 1 (2%)
Penis (1) (1)
Prostate (60) (49) (50) (60)
Testes (60) (49) (50) (60)
Interstitial Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (2) (1) (1)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (50%)
Lymph Node, Mandibular (53) (47) (47) (59)
Lymph Node, Mesenteric (57) (50) (47) (60)
Hemangiosarcoma 1 (2%)
Spleen (60) (50) (50) (60)
Hemangiosarcoma 4 (7%) 5 (10%) 1 (2%)
Hemangiosarcoma, Multiple 2 (3%) 1 (2%)
Thymus (39) (39) (37) (41)
Hemangiosarcoma 1 (3%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (50) (50) (60)
Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Paraganglioma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (48) (50) (60)
Vertebra, Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1) (1)
Diaphragm, Carcinoma, Metastatic, Pancreas 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (50) (50) (60)
Histiocytic Sarcoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (50) (50) (60)
Alveolar/Bronchiolar Adenoma 6 (10%) 1 (2%) 6 (12%) 6 (10%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 5 (8%) 5 (10%) 4 (8%) 3 (5%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Carcinoma, Metastatic, Liver 1 (2%)
Carcinoma, Metastatic, Pancreas 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 2 (4%) 2 (4%) 4 (7%)
Nose (60) (49) (50) (60)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (2) (3)
Adenoma 1 (100%) 2 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (50) (50) (60)
Page 9
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(53) *(51) *(60)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%) 1 (2%) 1 (2%)
Lymphoma Malignant Mixed 2 (3%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 30 28 34 32
Total Primary Neoplasms 52 40 45 45
Total Animals with Benign Neoplasms 19 20 24 23
Total Benign Neoplasms 28 25 28 26
Total Animals with Malignant Neoplasms 19 14 15 17
Total Malignant Neoplasms 24 15 17 19
Total Animals with Metastatic Neoplasms 2 3 2 5
Total Metastatic Neoplasm 2 5 2 8
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------