TDMS Study 05106-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Hazelton, MD DIETHYLPHTHALATE DATE: 05/19/95
EXPERIMENT: 05106 TEST: 03 TIME: 21:47:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45036 ROUTE: DERMAL,SOLUTION NTP C#: 60048B
PATHOLOGIST: R. CARDY S. EUSTIS CAS: 84-66-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Hazelton, MD DIETHYLPHTHALATE DATE: 05/19/95
EXPERIMENT: 05106 TEST: 03 TIME: 21:47:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45036 ROUTE: DERMAL,SOLUTION NTP C#: 60048B
PATHOLOGIST: R. CARDY S. EUSTIS CAS: 84-66-2
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Gland
Adrenal Medulla
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Hazelton, MD DIETHYLPHTHALATE DATE: 05/19/95
EXPERIMENT: 05106 TEST: 03 TIME: 21:47:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45036 ROUTE: DERMAL,SOLUTION NTP C#: 60048B
PATHOLOGIST: R. CARDY S. EUSTIS CAS: 84-66-2
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF DIETHYLPHTHALATE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Cortex Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Spleen Hemangiosarcoma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Skin Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal
Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma
Squamous Cell Carcinoma, Basal Cell Carcinoma, Basosquamous Tumor
(malignant or NOS), or Carcinoma
Spleen Hemangiosarcoma
Thyroid Gland: Follicular Cell
Carcinoma or Adenoma
Uterus Sarcoma Stromal or Polyp Stromal
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/60 (13%) 5/49 (10%) 2/49 (4%) 4/60 (7%) | 2/60 (3%) 1/51 (2%) 1/50 (2%) 1/60 (2%) |
|ADJUSTED (b) | 18.6% 12.2% 4.4% 9.3% | 4.9% 2.6% 2.7% 2.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) | 0/10 (0%) 0/0 0/0 0/10 (0%) |
|TERMINAL (d) | 8/43 (19%) 5/41 (12%) 2/45 (4%) 4/43 (9%) | 2/41 (5%) 1/38 (3%) 1/37 (3%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 730 (T) 730 (T) 730 (T) | 730 (T) 730 (T) 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.110N P=0.306N P=0.040N* P=0.177N | P=0.449N P=0.527N P=0.536N P=0.545N |
|INCIDENTAL TUMOR | P=0.110N P=0.306N P=0.040N* P=0.177N | P=0.449N P=0.527N P=0.536N P=0.545N |
|LOGISTIC REGRESSION | P=0.110N P=0.306N P=0.040N* P=0.177N | P=0.449N P=0.527N P=0.536N P=0.545N |
|COCHRAN-ARMITAGE | P=0.114N | P=0.401N |
|FISHER EXACT | P=0.422N P=0.089N P=0.181N | P=0.561N P=0.569N P=0.500N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/49 (2%) 0/60 (0%) | 4/60 (7%) 0/51 (0%) 0/50 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.2% 0.0% | 9.3% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) | 0/10 (0%) 0/0 0/0 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/41 (0%) 1/45 (2%) 0/43 (0%) | 3/41 (7%) 0/38 (0%) 0/37 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 730 (T) --- | 662 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.697 (e) P=0.509 (e) | P=0.026N* P=0.076N P=0.081N P=0.082N |
|INCIDENTAL TUMOR | P=0.697 (e) P=0.509 (e) | P=0.021N* P=0.079N P=0.082N P=0.063N |
|LOGISTIC REGRESSION | P=0.697 (e) P=0.509 (e) | P=0.023N* P=0.076N P=0.078N P=0.069N |
|COCHRAN-ARMITAGE | P=0.692 | P=0.023N* |
|FISHER EXACT | (e) P=0.450 (e) | P=0.081N P=0.084N P=0.059N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/53 (4%) 3/51 (6%) 0/60 (0%) | 1/60 (2%) 1/55 (2%) 4/53 (8%) 0/60 (0%) |
|ADJUSTED (b) | 1.7% 4.4% 6.5% 0.0% | 2.4% 2.6% 10.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/41 (0%) 3/46 (7%) 0/43 (0%) | 1/41 (2%) 1/38 (3%) 4/37 (11%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 590 730 (T) --- | 730 (T) 730 (T) 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.327N P=0.361 P=0.171 P=0.500N | P=0.488N P=0.745 P=0.150 P=0.526N |
|INCIDENTAL TUMOR | P=0.341N P=0.362 P=0.171 P=0.500N | P=0.488N P=0.745 P=0.150 P=0.526N |
|LOGISTIC REGRESSION | P=0.329N P=0.514 P=0.166 P=0.535N | P=0.488N P=0.745 P=0.150 P=0.526N |
|COCHRAN-ARMITAGE | P=0.334N | P=0.440N |
|FISHER EXACT | P=0.453 P=0.250 P=0.500N | P=0.730 P=0.146 P=0.500N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/53 (4%) 3/51 (6%) 0/60 (0%) | 1/60 (2%) 1/55 (2%) 5/53 (9%) 0/60 (0%) |
|ADJUSTED (b) | 1.7% 4.4% 6.5% 0.0% | 2.4% 2.6% 13.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/41 (0%) 3/46 (7%) 0/43 (0%) | 1/41 (2%) 1/38 (3%) 5/37 (14%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 590 730 (T) --- | 730 (T) 730 (T) 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.327N P=0.361 P=0.171 P=0.500N | P=0.522N P=0.745 P=0.081 P=0.526N |
|INCIDENTAL TUMOR | P=0.341N P=0.362 P=0.171 P=0.500N | P=0.522N P=0.745 P=0.081 P=0.526N |
|LOGISTIC REGRESSION | P=0.329N P=0.514 P=0.166 P=0.535N | P=0.522N P=0.745 P=0.081 P=0.526N |
|COCHRAN-ARMITAGE | P=0.334N | P=0.469N |
|FISHER EXACT | P=0.453 P=0.250 P=0.500N | P=0.730 P=0.077 P=0.500N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/49 (0%) 0/50 (0%) 0/60 (0%) | 2/60 (3%) 0/51 (0%) 0/50 (0%) 0/59 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 4.9% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) | 0/10 (0%) 0/0 0/0 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/40 (0%) 0/46 (0%) 0/43 (0%) | 2/41 (5%) 0/38 (0%) 0/37 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 730 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.129N P=0.255N P=0.261N P=0.274N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.129N P=0.255N P=0.261N P=0.274N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.129N P=0.255N P=0.261N P=0.274N |
|COCHRAN-ARMITAGE | (e) | P=0.121N |
|FISHER EXACT | (e) (e) (e) | P=0.290N P=0.295N P=0.252N |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/53 (2%) 0/51 (0%) 2/60 (3%) | 0/60 (0%) 1/55 (2%) 1/53 (2%) 0/60 (0%) |
|ADJUSTED (b) | 2.1% 2.4% 0.0% 4.7% | 0.0% 2.6% 2.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 1/41 (2%) 0/46 (0%) 2/43 (5%) | 0/41 (0%) 1/38 (3%) 0/37 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 558 730 (T) --- 730 (T) | --- 730 (T) 675 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.373 P=0.750 P=0.492N P=0.500 | P=0.611N P=0.485 P=0.476 (e) |
|INCIDENTAL TUMOR | P=0.368 P=0.755 P=0.718N P=0.500 | P=0.550N P=0.485 P=0.464 (e) |
|LOGISTIC REGRESSION | P=0.378 P=0.737 P=0.752N P=0.500 | P=0.597N P=0.485 P=0.476 (e) |
|COCHRAN-ARMITAGE | P=0.377 | P=0.590N |
|FISHER EXACT | P=0.720 P=0.541N P=0.500 | P=0.478 P=0.469 (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/60 (12%) 13/53 (25%) 10/51 (20%) 14/60 (23%) | 7/60 (12%) 12/55 (22%) 14/53 (26%) 11/60 (18%) |
|ADJUSTED (b) | 15.4% 29.1% 21.1% 30.3% | 14.3% 30.6% 35.5% 26.1% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 2/3 (67%) 1/1 (100%) 2/10 (20%) | 3/10 (30%) 0/4 (0%) 0/3 (0%) 1/10 (10%) |
|TERMINAL (d) | 6/43 (14%) 10/41 (24%) 9/46 (20%) 12/43 (28%) | 4/41 (10%) 11/38 (29%) 12/37 (32%) 7/36 (19%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 450 (I) 450 (I) 450 (I) | 450 (I) 675 586 450 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.141 P=0.039 * P=0.194 P=0.073 | P=0.189 P=0.067 P=0.018 * P=0.171 |
|INCIDENTAL TUMOR | P=0.139 P=0.040 * P=0.194 P=0.073 | P=0.243 P=0.065 P=0.023 * P=0.273 |
|LOGISTIC REGRESSION | P=0.127 P=0.062 P=0.197 P=0.076 | P=0.249 P=0.114 P=0.040 * P=0.227 |
|COCHRAN-ARMITAGE | P=0.125 | P=0.267 |
|FISHER EXACT | P=0.062 P=0.186 P=0.074 | P=0.113 P=0.038 * P=0.222 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 4/53 (8%) 6/51 (12%) 8/60 (13%) | 4/60 (7%) 5/55 (9%) 6/53 (11%) 4/60 (7%) |
|ADJUSTED (b) | 9.0% 8.9% 12.8% 16.0% | 8.8% 11.7% 14.4% 8.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 1/10 (10%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 1/10 (10%) |
|TERMINAL (d) | 3/43 (7%) 1/41 (2%) 5/46 (11%) 3/43 (7%) | 2/41 (5%) 2/38 (5%) 2/37 (5%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 635 576 714 450 (I) | 591 560 644 450 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.121 P=0.616 P=0.414 P=0.195 | P=0.540 P=0.449 P=0.313 P=0.604 |
|INCIDENTAL TUMOR | P=0.109 P=0.637 P=0.366 P=0.178 | P=0.433N P=0.592 P=0.473 P=0.581N |
|LOGISTIC REGRESSION | P=0.108 P=0.575 P=0.375 P=0.173 | P=0.464N P=0.533 P=0.457 P=0.566N |
|COCHRAN-ARMITAGE | P=0.113 | P=0.537N |
|FISHER EXACT | P=0.570 P=0.273 P=0.181 | P=0.445 P=0.295 P=0.641N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/60 (17%) 16/53 (30%) 15/51 (29%) 20/60 (33%) | 10/60 (17%) 16/55 (29%) 19/53 (36%) 14/60 (23%) |
|ADJUSTED (b) | 21.7% 34.5% 31.2% 40.1% | 20.1% 37.8% 45.0% 31.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 2/3 (67%) 1/1 (100%) 2/10 (20%) | 3/10 (30%) 0/4 (0%) 0/3 (0%) 2/10 (20%) |
|TERMINAL (d) | 8/43 (19%) 11/41 (27%) 13/46 (28%) 14/43 (33%) | 5/41 (12%) 12/38 (32%) 14/37 (38%) 7/36 (19%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 450 (I) 450 (I) 450 (I) | 450 (I) 560 586 450 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.055 P=0.058 P=0.131 P=0.035 * | P=0.220 P=0.061 P=0.012 * P=0.195 |
|INCIDENTAL TUMOR | P=0.052 P=0.054 P=0.112 P=0.030 * | P=0.316 P=0.070 P=0.021 * P=0.323 |
|LOGISTIC REGRESSION | P=0.044 * P=0.070 P=0.113 P=0.030 * | P=0.288 P=0.086 P=0.018 * P=0.255 |
|COCHRAN-ARMITAGE | P=0.043 * | P=0.300 |
|FISHER EXACT | P=0.069 P=0.085 P=0.028 * | P=0.086 P=0.017 * P=0.247 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/60 (17%) 16/53 (30%) 15/51 (29%) 20/60 (33%) | 10/60 (17%) 16/55 (29%) 19/53 (36%) 14/60 (23%) |
|ADJUSTED (b) | 21.7% 34.5% 31.2% 40.1% | 20.1% 37.8% 45.0% 31.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 2/3 (67%) 1/1 (100%) 2/10 (20%) | 3/10 (30%) 0/4 (0%) 0/3 (0%) 2/10 (20%) |
|TERMINAL (d) | 8/43 (19%) 11/41 (27%) 13/46 (28%) 14/43 (33%) | 5/41 (12%) 12/38 (32%) 14/37 (38%) 7/36 (19%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 450 (I) 450 (I) 450 (I) | 450 (I) 560 586 450 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.055 P=0.058 P=0.131 P=0.035 * | P=0.220 P=0.061 P=0.012 * P=0.195 |
|INCIDENTAL TUMOR | P=0.052 P=0.054 P=0.112 P=0.030 * | P=0.316 P=0.070 P=0.021 * P=0.323 |
|LOGISTIC REGRESSION | P=0.044 * P=0.070 P=0.113 P=0.030 * | P=0.288 P=0.086 P=0.018 * P=0.255 |
|COCHRAN-ARMITAGE | P=0.043 * | P=0.300 |
|FISHER EXACT | P=0.069 P=0.085 P=0.028 * | P=0.086 P=0.017 * P=0.247 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 2/50 (4%) 7/50 (14%) 7/60 (12%) | 2/60 (3%) 6/51 (12%) 4/50 (8%) 1/60 (2%) |
|ADJUSTED (b) | 13.1% 4.9% 14.9% 15.4% | 4.9% 15.0% 10.0% 2.8% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/0 0/0 1/10 (10%) | 0/10 (0%) 0/0 0/0 0/10 (0%) |
|TERMINAL (d) | 5/43 (12%) 2/41 (5%) 6/46 (13%) 6/43 (14%) | 2/41 (5%) 5/38 (13%) 3/37 (8%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 730 (T) 714 450 (I) | 730 (T) 560 521 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.291 P=0.236N P=0.428 P=0.500 | P=0.280N P=0.114 P=0.298 P=0.545N |
|INCIDENTAL TUMOR | P=0.304 P=0.236N P=0.448 P=0.500 | P=0.249N P=0.130 P=0.453 P=0.545N |
|LOGISTIC REGRESSION | P=0.278 P=0.188N P=0.433 P=0.503 | P=0.239N P=0.102 P=0.272 P=0.545N |
|COCHRAN-ARMITAGE | P=0.279 | P=0.228N |
|FISHER EXACT | P=0.203N P=0.361 P=0.500 | P=0.089 P=0.257 P=0.500N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 6/50 (12%) 4/50 (8%) 3/60 (5%) | 2/60 (3%) 3/51 (6%) 2/50 (4%) 1/60 (2%) |
|ADJUSTED (b) | 11.6% 14.6% 8.7% 7.0% | 4.8% 6.5% 4.9% 2.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) | 0/10 (0%) 0/0 0/0 0/10 (0%) |
|TERMINAL (d) | 5/43 (12%) 6/41 (15%) 4/46 (9%) 3/43 (7%) | 1/41 (2%) 0/38 (0%) 1/37 (3%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 730 (T) 730 (T) 730 (T) | 727 481 632 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.212N P=0.466 P=0.458N P=0.356N | P=0.341N P=0.474 P=0.656 P=0.548N |
|INCIDENTAL TUMOR | P=0.212N P=0.466 P=0.458N P=0.356N | P=0.211N P=0.552N P=0.653N P=0.484N |
|LOGISTIC REGRESSION | P=0.212N P=0.466 P=0.458N P=0.356N | P=0.300N P=0.390 P=0.649 P=0.539N |
|COCHRAN-ARMITAGE | P=0.216N | P=0.306N |
|FISHER EXACT | P=0.373 P=0.615N P=0.359N | P=0.423 P=0.619 P=0.500N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/60 (15%) 7/50 (14%) 10/50 (20%) 10/60 (17%) | 4/60 (7%) 9/51 (18%) 6/50 (12%) 2/60 (3%) |
|ADJUSTED (b) | 20.0% 17.1% 21.3% 22.2% | 9.5% 20.6% 14.7% 5.6% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/0 0/0 1/10 (10%) | 0/10 (0%) 0/0 0/0 0/10 (0%) |
|TERMINAL (d) | 8/43 (19%) 7/41 (17%) 9/46 (20%) 9/43 (21%) | 3/41 (7%) 5/38 (13%) 4/37 (11%) 2/36 (6%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 730 (T) 714 450 (I) | 727 481 521 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.401 P=0.540N P=0.459 P=0.500 | P=0.192N P=0.102 P=0.317 P=0.401N |
|INCIDENTAL TUMOR | P=0.413 P=0.540N P=0.477 P=0.500 | P=0.111N P=0.235 P=0.497 P=0.357N |
|LOGISTIC REGRESSION | P=0.396 P=0.484N P=0.470 P=0.507 | P=0.145N P=0.067 P=0.286 P=0.394N |
|COCHRAN-ARMITAGE | P=0.398 | P=0.142N |
|FISHER EXACT | P=0.551N P=0.330 P=0.500 | P=0.067 P=0.262 P=0.340N |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 3/59 (5%) 4/51 (8%) 2/49 (4%) 2/59 (3%) |
|ADJUSTED (b) | | 7.5% 10.5% 5.4% 5.4% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/0 0/0 0/10 (0%) |
|TERMINAL (d) | | 3/40 (8%) 4/38 (11%) 2/37 (5%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | | 730 (T) 730 (T) 730 (T) 725 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.365N P=0.472 P=0.536N P=0.550N |
|INCIDENTAL TUMOR | | P=0.339N P=0.472 P=0.536N P=0.502N |
|LOGISTIC REGRESSION | | P=0.359N P=0.472 P=0.536N P=0.540N |
|COCHRAN-ARMITAGE | | P=0.312N |
|FISHER EXACT | | P=0.419 P=0.588N P=0.500N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/58 (0%) 0/47 (0%) 0/48 (0%) 0/59 (0%) | 6/59 (10%) 4/48 (8%) 4/50 (8%) 1/59 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 13.9% 10.6% 10.0% 2.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) | 0/10 (0%) 0/0 0/0 0/10 (0%) |
|TERMINAL (d) | 0/42 (0%) 0/38 (0%) 0/45 (0%) 0/42 (0%) | 4/41 (10%) 3/36 (8%) 3/37 (8%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 675 682 521 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.068N P=0.445N P=0.436N P=0.088N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.036N* P=0.427N P=0.283N P=0.049N* |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.050N* P=0.237N P=0.440N P=0.069N |
|COCHRAN-ARMITAGE | (e) | P=0.046N* |
|FISHER EXACT | (e) (e) (e) | P=0.508N P=0.480N P=0.057N |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/53 (0%) 0/51 (0%) 0/60 (0%) | 0/60 (0%) 0/55 (0%) 0/53 (0%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 5.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/41 (0%) 0/46 (0%) 0/43 (0%) | 0/41 (0%) 0/38 (0%) 0/37 (0%) 2/36 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.040 * (e) (e) P=0.210 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.040 * (e) (e) P=0.210 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.040 * (e) (e) P=0.210 |
|COCHRAN-ARMITAGE | (e) | P=0.051 |
|FISHER EXACT | (e) (e) (e) | (e) (e) P=0.248 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/53 (0%) 0/51 (0%) 0/60 (0%) | 1/60 (2%) 5/55 (9%) 0/53 (0%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.4% 11.2% 0.0% 4.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/41 (0%) 0/46 (0%) 0/43 (0%) | 1/41 (2%) 2/38 (5%) 0/37 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 730 (T) 365 --- 633 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.524N P=0.094 P=0.520N P=0.475 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.439N P=0.196 P=0.520N P=0.531 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.485N P=0.082 P=0.520N P=0.498 |
|COCHRAN-ARMITAGE | (e) | P=0.493N |
|FISHER EXACT | (e) (e) (e) | P=0.084 P=0.531N P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/53 (0%) 0/51 (0%) 0/60 (0%) | 1/60 (2%) 2/55 (4%) 0/53 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.4% 4.7% 0.0% 2.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/41 (0%) 0/46 (0%) 0/43 (0%) | 1/41 (2%) 1/38 (3%) 0/37 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 730 (T) 509 --- 648 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.524N P=0.478 P=0.520N P=0.736 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.425N P=0.745 P=0.520N P=0.732N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.493N P=0.469 P=0.520N P=0.758 |
|COCHRAN-ARMITAGE | (e) | P=0.495N |
|FISHER EXACT | (e) (e) (e) | P=0.467 P=0.531N P=0.752N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/53 (0%) 0/51 (0%) 0/60 (0%) | 1/60 (2%) 5/55 (9%) 0/53 (0%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.4% 11.2% 0.0% 4.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/41 (0%) 0/46 (0%) 0/43 (0%) | 1/41 (2%) 2/38 (5%) 0/37 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 730 (T) 365 --- 633 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.524N P=0.094 P=0.520N P=0.475 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.439N P=0.196 P=0.520N P=0.531 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.485N P=0.082 P=0.520N P=0.498 |
|COCHRAN-ARMITAGE | (e) | P=0.493N |
|FISHER EXACT | (e) (e) (e) | P=0.084 P=0.531N P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/53 (0%) 0/51 (0%) 0/60 (0%) | 0/60 (0%) 0/55 (0%) 0/53 (0%) 0/60 (0%) |
|ADJUSTED (b) | 4.3% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/43 (2%) 0/41 (0%) 0/46 (0%) 0/43 (0%) | 0/41 (0%) 0/38 (0%) 0/37 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 536 --- --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.113N P=0.252N P=0.230N P=0.240N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.173N P=0.245N P=0.487N P=0.314N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.126N P=0.261N P=0.354N P=0.240N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.120N | (e) |
|FISHER EXACT | P=0.280N P=0.290N P=0.248N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Skin |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/53 (0%) 0/51 (0%) 0/60 (0%) | 0/60 (0%) 2/55 (4%) 0/53 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 4.2% 0.0% 2.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/41 (0%) 0/46 (0%) 0/43 (0%) | 0/41 (0%) 0/38 (0%) 0/37 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 365 --- 633 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.537 P=0.225 (e) P=0.500 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.563 P=0.290 (e) P=0.500 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.550 P=0.197 (e) P=0.503 |
|COCHRAN-ARMITAGE | (e) | P=0.542 |
|FISHER EXACT | (e) (e) (e) | P=0.227 (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Basal Cell Carcinoma, Basosquamous Tumor |
| (malignant or NOS), or Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/53 (0%) 0/51 (0%) 0/60 (0%) | 0/60 (0%) 0/55 (0%) 0/53 (0%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 5.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/41 (0%) 0/46 (0%) 0/43 (0%) | 0/41 (0%) 0/38 (0%) 0/37 (0%) 2/36 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.040 * (e) (e) P=0.210 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.040 * (e) (e) P=0.210 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.040 * (e) (e) P=0.210 |
|COCHRAN-ARMITAGE | (e) | P=0.051 |
|FISHER EXACT | (e) (e) (e) | (e) (e) P=0.248 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 0/50 (0%) 5/50 (10%) 2/60 (3%) | 0/60 (0%) 0/51 (0%) 3/50 (6%) 3/60 (5%) |
|ADJUSTED (b) | 13.4% 0.0% 10.3% 4.4% | 0.0% 0.0% 7.8% 6.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) | 0/10 (0%) 0/0 0/0 0/10 (0%) |
|TERMINAL (d) | 5/43 (12%) 0/41 (0%) 3/46 (7%) 1/43 (2%) | 0/41 (0%) 0/38 (0%) 2/37 (5%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 536 --- 663 675 | --- --- 675 645 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.225N P=0.022N* P=0.455N P=0.138N | P=0.032 * (e) P=0.105 P=0.113 |
|INCIDENTAL TUMOR | P=0.212N P=0.021N* P=0.544N P=0.148N | P=0.068 (e) P=0.101 P=0.186 |
|LOGISTIC REGRESSION | P=0.221N P=0.027N* P=0.584N P=0.133N | P=0.040 * (e) P=0.101 P=0.120 |
|COCHRAN-ARMITAGE | P=0.226N | P=0.042 * |
|FISHER EXACT | P=0.023N* P=0.627N P=0.136N | (e) P=0.091 P=0.122 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/53 (0%) 0/51 (0%) 0/60 (0%) | 0/60 (0%) 2/55 (4%) 0/53 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 5.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/41 (0%) 0/46 (0%) 0/43 (0%) | 0/41 (0%) 2/38 (5%) 0/37 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 730 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.430N P=0.222 (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.430N P=0.222 (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.430N P=0.222 (e) (e) |
|COCHRAN-ARMITAGE | (e) | P=0.404N |
|FISHER EXACT | (e) (e) (e) | P=0.227 (e) (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/53 (0%) 0/51 (0%) 0/60 (0%) | 1/60 (2%) 2/55 (4%) 0/53 (0%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.4% 5.3% 0.0% 5.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/41 (0%) 0/46 (0%) 0/43 (0%) | 1/41 (2%) 2/38 (5%) 0/37 (0%) 2/36 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 730 (T) 730 (T) --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.429 P=0.473 P=0.520N P=0.455 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.429 P=0.473 P=0.520N P=0.455 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.429 P=0.473 P=0.520N P=0.455 |
|COCHRAN-ARMITAGE | (e) | P=0.475 |
|FISHER EXACT | (e) (e) (e) | P=0.467 P=0.531N P=0.500 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/53 (0%) 0/51 (0%) 0/60 (0%) | 1/60 (2%) 0/55 (0%) 0/53 (0%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.4% 0.0% 0.0% 5.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/41 (0%) 0/46 (0%) 0/43 (0%) | 1/41 (2%) 0/38 (0%) 0/37 (0%) 2/36 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 730 (T) --- --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.221 P=0.515N P=0.520N P=0.455 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.221 P=0.515N P=0.520N P=0.455 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.221 P=0.515N P=0.520N P=0.455 |
|COCHRAN-ARMITAGE | (e) | P=0.254 |
|FISHER EXACT | (e) (e) (e) | P=0.522N P=0.531N P=0.500 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/50 (2%) 3/50 (6%) 0/60 (0%) | 1/60 (2%) 5/51 (10%) 1/50 (2%) 1/60 (2%) |
|ADJUSTED (b) | 4.4% 2.4% 6.5% 0.0% | 2.3% 12.8% 2.7% 2.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) | 0/10 (0%) 0/0 0/0 0/10 (0%) |
|TERMINAL (d) | 1/43 (2%) 1/41 (2%) 3/46 (7%) 0/43 (0%) | 0/41 (0%) 4/38 (11%) 1/37 (3%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | 558 730 (T) 730 (T) --- | 675 718 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.236N P=0.516N P=0.528 P=0.240N | P=0.358N P=0.091 P=0.735 P=0.741 |
|INCIDENTAL TUMOR | P=0.244N P=0.511N P=0.432 P=0.240N | P=0.301N P=0.080 P=0.728 P=0.732N |
|LOGISTIC REGRESSION | P=0.235N P=0.564N P=0.418 P=0.239N | P=0.332N P=0.083 P=0.734 P=0.755 |
|COCHRAN-ARMITAGE | P=0.239N | P=0.306N |
|FISHER EXACT | P=0.569N P=0.414 P=0.248N | P=0.070 P=0.705 P=0.752N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/50 (2%) 3/50 (6%) 0/60 (0%) | 1/60 (2%) 6/51 (12%) 1/50 (2%) 1/60 (2%) |
|ADJUSTED (b) | 4.4% 2.4% 6.5% 0.0% | 2.3% 15.4% 2.7% 2.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) | 0/10 (0%) 0/0 0/0 0/10 (0%) |
|TERMINAL (d) | 1/43 (2%) 1/41 (2%) 3/46 (7%) 0/43 (0%) | 0/41 (0%) 5/38 (13%) 1/37 (3%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | 558 730 (T) 730 (T) --- | 675 718 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.236N P=0.516N P=0.528 P=0.240N | P=0.308N P=0.050 P=0.735 P=0.741 |
|INCIDENTAL TUMOR | P=0.244N P=0.511N P=0.432 P=0.240N | P=0.259N P=0.043 * P=0.728 P=0.732N |
|LOGISTIC REGRESSION | P=0.235N P=0.564N P=0.418 P=0.239N | P=0.283N P=0.044 * P=0.734 P=0.755 |
|COCHRAN-ARMITAGE | P=0.239N | P=0.258N |
|FISHER EXACT | P=0.569N P=0.414 P=0.248N | P=0.035 * P=0.705 P=0.752N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Tissue NOS |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/53 (0%) 0/51 (0%) 0/60 (0%) | 1/60 (2%) 1/55 (2%) 2/53 (4%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.4% 2.6% 5.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/41 (0%) 0/46 (0%) 0/43 (0%) | 1/41 (2%) 1/38 (3%) 1/37 (3%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 730 (T) 730 (T) 675 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.396N P=0.745 P=0.462 P=0.526N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.358N P=0.745 P=0.455 P=0.526N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.378N P=0.745 P=0.466 P=0.526N |
|COCHRAN-ARMITAGE | (e) | P=0.365N |
|FISHER EXACT | (e) (e) (e) | P=0.730 P=0.453 P=0.500N |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 3/60 (5%) 1/55 (2%) 1/53 (2%) 0/60 (0%) |
|ADJUSTED (b) | | 6.6% 2.6% 2.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | | 1/41 (2%) 1/38 (3%) 1/37 (3%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | | 662 730 (T) 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.088N P=0.334N P=0.352N P=0.143N |
|INCIDENTAL TUMOR | | P=0.064N P=0.351N P=0.356N P=0.081N |
|LOGISTIC REGRESSION | | P=0.078N P=0.335N P=0.343N P=0.124N |
|COCHRAN-ARMITAGE | | P=0.076N |
|FISHER EXACT | | P=0.343N P=0.357N P=0.122N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 4/60 (7%) 1/55 (2%) 1/53 (2%) 0/60 (0%) |
|ADJUSTED (b) | | 8.7% 2.6% 2.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | | 1/41 (2%) 1/38 (3%) 1/37 (3%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | | 662 730 (T) 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.044N* P=0.207N P=0.224N P=0.081N |
|INCIDENTAL TUMOR | | P=0.026N* P=0.214N P=0.218N P=0.029N* |
|LOGISTIC REGRESSION | | P=0.037N* P=0.206N P=0.214N P=0.065N |
|COCHRAN-ARMITAGE | | P=0.037N* |
|FISHER EXACT | | P=0.210N P=0.223N P=0.059N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 10/60 (17%) 1/53 (2%) 6/51 (12%) 4/60 (7%) | 1/60 (2%) 2/55 (4%) 4/53 (8%) 4/60 (7%) |
|ADJUSTED (b) | 21.9% 2.4% 12.1% 9.0% | 2.4% 5.3% 10.5% 9.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 8/43 (19%) 1/41 (2%) 3/46 (7%) 3/43 (7%) | 1/41 (2%) 2/38 (5%) 3/37 (8%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 536 730 (T) 633 675 | 730 (T) 730 (T) 675 645 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.140N P=0.008N** P=0.179N P=0.080N | P=0.100 P=0.473 P=0.151 P=0.164 |
|INCIDENTAL TUMOR | P=0.138N P=0.007N** P=0.306N P=0.085N | P=0.166 P=0.473 P=0.148 P=0.264 |
|LOGISTIC REGRESSION | P=0.128N P=0.009N** P=0.288N P=0.075N | P=0.113 P=0.473 P=0.150 P=0.175 |
|COCHRAN-ARMITAGE | P=0.145N | P=0.124 |
|FISHER EXACT | P=0.007N** P=0.324N P=0.077N | P=0.467 P=0.146 P=0.182 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 10/60 (17%) 2/53 (4%) 6/51 (12%) 5/60 (8%) | 2/60 (3%) 2/55 (4%) 4/53 (8%) 4/60 (7%) |
|ADJUSTED (b) | 21.9% 4.9% 12.1% 11.3% | 4.9% 5.3% 10.5% 9.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 8/43 (19%) 2/41 (5%) 3/46 (7%) 4/43 (9%) | 2/41 (5%) 2/38 (5%) 3/37 (8%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 536 730 (T) 633 675 | 730 (T) 730 (T) 675 645 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.206N P=0.021N* P=0.179N P=0.137N | P=0.184 P=0.667 P=0.291 P=0.305 |
|INCIDENTAL TUMOR | P=0.204N P=0.020N* P=0.306N P=0.144N | P=0.275 P=0.667 P=0.287 P=0.441 |
|LOGISTIC REGRESSION | P=0.192N P=0.025N* P=0.288N P=0.130N | P=0.206 P=0.667 P=0.290 P=0.327 |
|COCHRAN-ARMITAGE | P=0.211N | P=0.223 |
|FISHER EXACT | P=0.025N* P=0.324N P=0.135N | P=0.657 P=0.282 P=0.340 |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/53 (2%) 0/51 (0%) 0/60 (0%) | 0/60 (0%) 3/55 (5%) 1/53 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 2.0% 0.0% 0.0% | 0.0% 7.2% 2.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 0/10 (0%) 0/4 (0%) 0/3 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/41 (0%) 0/46 (0%) 0/43 (0%) | 0/41 (0%) 2/38 (5%) 0/37 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- 378 --- --- | --- 484 586 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.560N P=0.468 (e) (e) | P=0.387N P=0.113 P=0.483 (e) |
|INCIDENTAL TUMOR | P=0.707N P=0.500 (e) (e) | P=0.321N P=0.222 P=0.682 (e) |
|LOGISTIC REGRESSION | P=0.658N P=0.629 (e) (e) | P=0.361N P=0.105 P=0.463 (e) |
|COCHRAN-ARMITAGE | P=0.562N | P=0.365N |
|FISHER EXACT | P=0.469 (e) (e) | P=0.106 P=0.469 (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 4/53 (8%) 0/51 (0%) 3/60 (5%) | 7/60 (12%) 15/55 (27%) 9/53 (17%) 8/60 (13%) |
|ADJUSTED (b) | 7.0% 8.4% 0.0% 6.7% | 15.2% 34.1% 20.9% 18.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 1/10 (10%) 0/4 (0%) 0/3 (0%) 1/10 (10%) |
|TERMINAL (d) | 3/43 (7%) 1/41 (2%) 0/46 (0%) 1/43 (2%) | 4/41 (10%) 10/38 (26%) 4/37 (11%) 3/36 (8%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 378 --- 698 | 450 (I) 273 568 450 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.444N P=0.456 P=0.110N P=0.659N | P=0.472N P=0.031 * P=0.271 P=0.424 |
|INCIDENTAL TUMOR | P=0.480N P=0.485 P=0.110N P=0.603N | P=0.307N P=0.050 P=0.330 P=0.561 |
|LOGISTIC REGRESSION | P=0.459N P=0.445 P=0.110N P=0.659N | P=0.386N P=0.030 * P=0.429 P=0.492 |
|COCHRAN-ARMITAGE | P=0.446N | P=0.382N |
|FISHER EXACT | P=0.431 P=0.154N P=0.660N | P=0.029 * P=0.295 P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 3/53 (6%) 0/51 (0%) 3/60 (5%) | 7/60 (12%) 13/55 (24%) 8/53 (15%) 8/60 (13%) |
|ADJUSTED (b) | 7.0% 6.6% 0.0% 6.7% | 15.2% 30.3% 19.1% 18.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 0/10 (0%) | 1/10 (10%) 0/4 (0%) 0/3 (0%) 1/10 (10%) |
|TERMINAL (d) | 3/43 (7%) 1/41 (2%) 0/46 (0%) 1/43 (2%) | 4/41 (10%) 9/38 (24%) 4/37 (11%) 3/36 (8%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 397 --- 698 | 450 (I) 273 568 450 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.510N P=0.628 P=0.110N P=0.659N | P=0.525N P=0.072 P=0.363 P=0.424 |
|INCIDENTAL TUMOR | P=0.499N P=0.646 P=0.110N P=0.603N | P=0.373N P=0.078 P=0.388 P=0.561 |
|LOGISTIC REGRESSION | P=0.511N P=0.604 P=0.110N P=0.659N | P=0.446N P=0.075 P=0.407 P=0.492 |
|COCHRAN-ARMITAGE | P=0.512N | P=0.437N |
|FISHER EXACT | P=0.600 P=0.154N P=0.660N | P=0.074 P=0.397 P=0.500 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 19/60 (32%) 20/53 (38%) 24/51 (47%) 23/60 (38%) | 24/60 (40%) 26/55 (47%) 26/53 (49%) 17/60 (28%) |
|ADJUSTED (b) | 39.5% 43.1% 49.9% 49.2% | 48.1% 61.8% 62.9% 40.5% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 2/3 (67%) 1/1 (100%) 3/10 (30%) | 4/10 (40%) 0/4 (0%) 0/3 (0%) 1/10 (10%) |
|TERMINAL (d) | 15/43 (35%) 15/41 (37%) 22/46 (48%) 20/43 (47%) | 16/41 (39%) 22/38 (58%) 22/37 (59%) 12/36 (33%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 450 (I) 450 (I) 450 (I) | 450 (I) 560 521 450 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.282 P=0.247 P=0.115 P=0.280 | P=0.169N P=0.210 P=0.156 P=0.240N |
|INCIDENTAL TUMOR | P=0.281 P=0.241 P=0.101 P=0.280 | P=0.078N P=0.185 P=0.235 P=0.097N |
|LOGISTIC REGRESSION | P=0.263 P=0.318 P=0.095 P=0.287 | P=0.080N P=0.278 P=0.240 P=0.133N |
|COCHRAN-ARMITAGE | P=0.254 | P=0.070N |
|FISHER EXACT | P=0.316 P=0.072 P=0.283 | P=0.275 P=0.218 P=0.124N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 19/60 (32%) 14/53 (26%) 15/51 (29%) 17/60 (28%) | 18/60 (30%) 27/55 (49%) 23/53 (43%) 20/60 (33%) |
|ADJUSTED (b) | 41.1% 29.5% 30.0% 33.8% | 35.4% 53.7% 47.8% 39.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/3 (0%) 0/1 (0%) 1/10 (10%) | 1/10 (10%) 0/4 (0%) 0/3 (0%) 2/10 (20%) |
|TERMINAL (d) | 16/43 (37%) 8/41 (20%) 11/46 (24%) 10/43 (23%) | 9/41 (22%) 15/38 (39%) 12/37 (32%) 6/36 (17%) |
|FIRST INCIDENCE (DAYS) | 536 378 633 450 (I) | 193 273 393 450 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.433N P=0.273N P=0.209N P=0.420N | P=0.458 P=0.050 P=0.131 P=0.330 |
|INCIDENTAL TUMOR | P=0.440N P=0.229N P=0.331N P=0.395N | P=0.268N P=0.121 P=0.277 P=0.517N |
|LOGISTIC REGRESSION | P=0.388N P=0.337N P=0.304N P=0.371N | P=0.465N P=0.027 * P=0.098 P=0.424 |
|COCHRAN-ARMITAGE | P=0.438N | P=0.472N |
|FISHER EXACT | P=0.343N P=0.481N P=0.421N | P=0.028 * P=0.100 P=0.422 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 03 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO | 0 MICROL 7.5 MICR 15 MICRO 30 MICRO |
| | ITERS OLITERS LITERS LITERS | ITERS OLITERS LITERS LITERS |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 30/60 (50%) 28/53 (53%) 34/51 (67%) 32/60 (53%) | 36/60 (60%) 41/55 (75%) 38/53 (72%) 31/60 (52%) |
|ADJUSTED (b) | 60.6% 55.9% 66.7% 61.2% | 65.1% 81.9% 77.5% 60.4% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 2/3 (67%) 1/1 (100%) 3/10 (30%) | 5/10 (50%) 0/4 (0%) 0/3 (0%) 3/10 (30%) |
|TERMINAL (d) | 24/43 (56%) 19/41 (46%) 29/46 (63%) 23/43 (53%) | 22/41 (54%) 29/38 (76%) 26/37 (70%) 16/36 (44%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 378 450 (I) 450 (I) | 193 273 393 450 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.398 P=0.427 P=0.217 P=0.438 | P=0.303N P=0.087 P=0.131 P=0.449N |
|INCIDENTAL TUMOR | P=0.368 P=0.445 P=0.100 P=0.446 | P=0.047N* P=0.198 P=0.323 P=0.136N |
|LOGISTIC REGRESSION | P=0.365 P=0.456 P=0.106 P=0.437 | P=0.095N P=0.073 P=0.141 P=0.238N |
|COCHRAN-ARMITAGE | P=0.351 | P=0.089N |
|FISHER EXACT | P=0.456 P=0.057 P=0.428 | P=0.072 P=0.134 P=0.231N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 450
Female interim sacrifices(days): 450
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).