TDMS Study 05106-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Hazelton, MD DIETHYLPHTHALATE DATE: 05/19/95
EXPERIMENT: 05106 TEST: 03 TIME: 21:47:31
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45036 ROUTE: DERMAL,SOLUTION NTP C#: 60048B
PATHOLOGIST: R. CARDY S. EUSTIS CAS: 84-66-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Hazelton, MD DIETHYLPHTHALATE DATE: 05/19/95
EXPERIMENT: 05106 TEST: 03 TIME: 21:47:31
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45036 ROUTE: DERMAL,SOLUTION NTP C#: 60048B
PATHOLOGIST: R. CARDY S. EUSTIS CAS: 84-66-2
DIETHYLPHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MICROLITERS |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 7 CENSORED DEATHS 10 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 431 536 558 620 635 690 716 |
| CENSORED DEATHS |
| 450 450 450 450 450 451 451 451 451 451 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 7.5 MICROLITERS |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 7 CENSORED DEATHS 12 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 378 397 576 590 590 680 727 |
| CENSORED DEATHS |
| 29 165 450 450 450 450 450 451 451 451 |
| 451 451 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 15 MICROLITERS |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 4 CENSORED DEATHS 10 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 633 663 695 714 |
| CENSORED DEATHS |
| 450 450 450 450 450 450 450 451 451 451 |
| |
==================================================================================
DIETHYLPHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 30 MICROLITERS |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 7 CENSORED DEATHS 10 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 512 556 577 644 675 698 707 |
| CENSORED DEATHS |
| 450 450 450 451 451 451 451 451 451 451 |
| |
==================================================================================
DIETHYLPHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 100.0 100.0 100.0 100.0 98.3 96.3 94.3 90.3 86.3 |
|MICROLITERS| |
| | |
|7.5 | 100.0 100.0 100.0 100.0 96.6 96.6 96.6 90.3 90.3 86.1 |
|MICROLITERS| |
| | |
|15 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 92.0 |
|MICROLITERS| |
| | |
|30 | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 94.0 92.0 86.0 |
|MICROLITERS| |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 7.5 15 30 |
| MICROLITERS MICROLITERS MICROLITERS MICROLITE|S
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 86.3% 86.1% 92.0% 86.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.980N P=1.000 P=0.486N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 598.0 562.6 676.3 624.1 |
|NATURAL DEATHS (C) | (37.0) (49.8) (17.8) (28.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 668.0 642.8 679.8 671.1 |
|(STANDARD ERROR) | (14.4) (20.1) (13.5) (13.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIETHYLPHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MICROLITERS |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 9 CENSORED DEATHS 10 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 193 591 620 662 663 665 675 724 727 |
| CENSORED DEATHS |
| 450 450 450 450 450 450 450 450 451 451 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 7.5 MICROLITERS |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 9 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 273 365 481 484 509 560 563 597 668 675 |
| 678 682 718 |
| CENSORED DEATHS |
| 450 450 451 451 451 451 451 451 451 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 15 MICROLITERS |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 12 CENSORED DEATHS 11 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 393 521 568 583 586 632 644 653 661 673 |
| 675 708 |
| CENSORED DEATHS |
| 193 450 450 450 450 450 451 451 451 451 |
| 451 |
| |
==================================================================================
DIETHYLPHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 30 MICROLITERS |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 11 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 456 521 633 636 645 645 648 691 693 693 |
| 712 712 725 |
| CENSORED DEATHS |
| 247 450 450 450 450 450 451 451 451 451 |
| 451 |
| |
==================================================================================
DIETHYLPHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 100.0 98.3 98.3 98.3 98.3 98.3 96.3 88.3 82.3 |
|MICROLITERS| |
| | |
|7.5 | 100.0 100.0 100.0 96.7 96.7 92.7 90.7 84.8 84.8 75.0 |
|MICROLITERS| |
| | |
|15 | 100.0 100.0 100.0 100.0 98.3 98.3 96.3 90.1 81.9 75.8 |
|MICROLITERS| |
| | |
|30 | 100.0 100.0 100.0 100.0 100.0 98.0 95.9 95.9 85.7 73.5 |
|MICROLITERS| |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 7.5 15 30 |
| MICROLITERS MICROLITERS MICROLITERS MICROLITE|S
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 82.3% 75.0% 75.8% 73.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.507 P=0.439 P=0.514 P=0.433 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 613.3 557.9 608.1 646.9 |
|NATURAL DEATHS (C) | (54.5) (37.1) (24.9) (21.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 665.9 650.8 650.1 657.4 |
|(STANDARD ERROR) | (15.7) (16.2) (16.4) (15.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIETHYLPHTHALATE
KAPLAN-MEIER SURVIVAL CURVES
0 MICROLITERS = 1
7.5 MICROLITERS = 2
15 MICROLITERS = 3
30 MICROLITERS = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 4 3
|
|
| 2 2 1 1
98 + 4 4 3 3
|
P |
E | 2 1 1 2
R 96 + 4 4 3 3
C |
E |
N | 1 2 2 1
T 94 + 4 4 3 3
|
S |
U | 1 1
R 92 + 4 4 3 3
V |
I |
V | 2 1 21
A 90 + 4 4
L |
|
| 1 1
88 + 2 44 2
|
|
| 1 1
86 + 4 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.
DIETHYLPHTHALATE
KAPLAN-MEIER SURVIVAL CURVES
0 MICROLITERS = 1
7.5 MICROLITERS = 2
15 MICROLITERS = 3
30 MICROLITERS = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3 4
| 1 2 2 3 3 1
| 4 4
| 2 2 3 3 1 1 4
P 95 + 22
E | 3 3 1 1
R | 2 2
C | 2 2 4 4
E 90 + 3 3
N | 22 1 1
T | 33
| 2 2 343 1 4 1
S 85 + 2 2
U | 3 3
R | 322 1 1
V |
I 80 + 4 4
V | 22
A | 32 32
L | 3 3
75 + 424 2
| 4 4
|
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.