TDMS Study 05106-01 Pathology Tables
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
Facility: Hazleton, Maryland
Chemical CAS #: 84-66-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 3| 3| 3| 1| 9| 5| 7| 3| 3| 3| 5| 0| 5| 3| 3|
| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 4| 4| 4| 7| 3| 2| 9| 4| 4| 4| 0| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + +|
Rectum, Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + A A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Monocytic | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
Medulla, Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 3| 3| 3| 1| 9| 5| 7| 3| 3| 3| 5| 0| 5| 3| 3|
| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 4| 4| 4| 7| 3| 2| 9| 4| 4| 4| 0| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X |
Pars Distalis, Carcinoma | X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X|
Leukemia Mononuclear | X |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + M + + + + + +|
Adenoma | X X X |
Carcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
Schwannoma Malignant | X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M I + + + + + + + + M + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 3| 3| 3| 1| 9| 5| 7| 3| 3| 3| 5| 0| 5| 3| 3|
| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 4| 4| 4| 7| 3| 2| 9| 4| 4| 4| 0| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Adenocarcinoma | X |
Adenoma | |
Fibroadenoma | X X X X X X X |
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Monocytic | |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5| 3| 3| 3| 5| 6| 3| 3|
| 4| 4| 4| 9| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 5| 8| 4| 4| 4| 1| 2| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Rectum, Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Monocytic | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Leukemia Mononuclear | X X |
Medulla, Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + M + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5| 3| 3| 3| 5| 6| 3| 3|
| 4| 4| 4| 9| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 5| 8| 4| 4| 4| 1| 2| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
C-Cell, Carcinoma | X X X X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + M + + + + + + + + M + + +|
Adenoma | X X |
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
Schwannoma Malignant | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + M + + + A + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + M + + M + + + + + + + + + + + + + M + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5| 3| 3| 3| 5| 6| 3| 3|
| 4| 4| 4| 9| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 5| 8| 4| 4| 4| 1| 2| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Adenocarcinoma | X |
Adenoma | |
Fibroadenoma | X X X X X X X X X X X|
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + M + + + A + + + + + + +|
Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + I + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Monocytic | X |
Leukemia Mononuclear | X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 6| 3| 5| 1| | |
| 5| 5| 5| 5| 3| 0| 5| 4| 6| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
Rectum, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X | 18 |
__________________________________________________________________________|____________|
Mesentery | | 3 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Leukemia Monocytic | | 1 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Adenoma | X X | 4 |
Leukemia Mononuclear | | 2 |
Medulla, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 58 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 6| 3| 5| 1| | |
| 5| 5| 5| 5| 3| 0| 5| 4| 6| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | | 3 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + | 54 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 4 |
Pars Distalis, Adenoma | X X X X X X X X X | 42 |
Pars Distalis, Carcinoma | X | 2 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Adenoma | | 1 |
Leukemia Mononuclear | | 1 |
C-Cell, Carcinoma | X | 6 |
Follicular Cell, Carcinoma | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + | 53 |
Adenoma | | 5 |
Carcinoma | X | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Polyp Stromal | | 2 |
Schwannoma Malignant | | 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 2 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 6| 3| 5| 1| | |
| 5| 5| 5| 5| 3| 0| 5| 4| 6| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 17 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 53 |
Leukemia Mononuclear | | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Adenocarcinoma | X X X | 5 |
Adenoma | X | 1 |
Fibroadenoma | X X X X | 22 |
Fibroadenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 57 |
Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Carcinoma, Metastatic | | 1 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | X | 12 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 6| 3| 5| 1| | |
| 5| 5| 5| 5| 3| 0| 5| 4| 6| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + | 57 |
Leukemia Mononuclear | | 1 |
Papilloma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Monocytic | | 1 |
Leukemia Mononuclear | X X | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 6| 4| 7| 5| 7| 7| 6| 7| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 5| 1| 3| 6| 3| 3| 4| 3| 3| 3| 7| 5| 4|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 5| 4| 9| 5| 8| 5| 5| 5| 5| 5| 5| 3| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + A A A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A A A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 6| 4| 7| 5| 7| 7| 6| 7| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 5| 1| 3| 6| 3| 3| 4| 3| 3| 3| 7| 5| 4|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 5| 4| 9| 5| 8| 5| 5| 5| 5| 5| 5| 3| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Basosquamous Tumor Malignant | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + M + M + + + + + + M M +|
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Deep Cervical, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + M + M + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X X X |
Fibroadenoma, Multiple | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 6| 4| 7| 5| 7| 7| 6| 7| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 5| 1| 3| 6| 3| 3| 4| 3| 3| 3| 7| 5| 4|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 5| 4| 9| 5| 8| 5| 5| 5| 5| 5| 5| 3| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Carcinoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + I + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 4| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 7| 9| 1| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 3|
| 5| 5| 5| 7| 3| 4| 3| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 4| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 7| 9| 1| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 3|
| 5| 5| 5| 7| 3| 4| 3| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Carcinoma | X X X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Basosquamous Tumor Malignant | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M M M + + M M + + + + + + + + + + + + + + +|
Carcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + M + + + M + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X |
Fibroadenoma | X X X X X |
Fibroadenoma, Multiple | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 4| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 7| 9| 1| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 3|
| 5| 5| 5| 7| 3| 4| 3| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Control | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | +|
Carcinoma | X|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + I + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 5| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 5| 3| 5| 7| 3| 3| 3| 3| 0| | |
| 3| 1| 5| 5| 4| 5| 5| 5| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + A | 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + A | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + A | 47 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + A | 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 52 |
Hepatocellular Adenoma | X | 1 |
Leukemia Mononuclear | X X | 13 |
__________________________________________________________________________|____________|
Mesentery | | 3 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 51 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Adenoma | X | 4 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Adenoma | | 1 |
Carcinoma | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 5| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 5| 3| 5| 7| 3| 3| 3| 3| 0| | |
| 3| 1| 5| 5| 4| 5| 5| 5| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Pars Distalis, Adenoma | X X X X X X X | 33 |
Pars Distalis, Carcinoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
C-Cell, Carcinoma | X | 5 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Basosquamous Tumor Malignant | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + + + | 39 |
Carcinoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Polyp Stromal | X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + M + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 52 |
Hemangiosarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 5| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 5| 3| 5| 7| 3| 3| 3| 3| 0| | |
| 3| 1| 5| 5| 4| 5| 5| 5| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X | 15 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + M + | 43 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + | 49 |
Adenocarcinoma | | 3 |
Fibroadenoma | X X X | 11 |
Fibroadenoma, Multiple | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + M + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Carcinoma, Metastatic | | 2 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 12 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 51 |
Carcinoma | X | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | M + + + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 52 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 5| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 5| 3| 5| 7| 3| 3| 3| 3| 0| | |
| 3| 1| 5| 5| 4| 5| 5| 5| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | X X X | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 5| 5| 5| 5| 7| 6| 7| 5| 3| 7| 6| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 6| 9| 9| 8| 3| 8| 3| 8| 6| 3| 5| 4| 2|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 9| 5| 1| 4| 4| 9| 4| 5| 7| 4| 7| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + A + + + A + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Adenoma, Multiple | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 5| 5| 5| 5| 7| 6| 7| 5| 3| 7| 6| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 6| 9| 9| 8| 3| 8| 3| 8| 6| 3| 5| 4| 2|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 9| 5| 1| 4| 4| 9| 4| 5| 7| 4| 7| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | +|
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + M M M + + + + + + + M M M|
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | |
Polyp Stromal | X |
Sarcoma Stromal | X|
Schwannoma Malignant | X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + M + I +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X |
Fibroma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 5| 5| 5| 5| 7| 6| 7| 5| 3| 7| 6| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 6| 9| 9| 8| 3| 8| 3| 8| 6| 3| 5| 4| 2|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 9| 5| 1| 4| 4| 9| 4| 5| 7| 4| 7| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 3| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 4| 3| 3| 8|
| 8| 5| 9| 5| 5| 9| 8| 5| 6| 5| 5| 4| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A A + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
Adenoma, Multiple | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + M + + +|
Adenoma | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 3| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 4| 3| 3| 8|
| 8| 5| 9| 5| 5| 9| 8| 5| 6| 5| 5| 4| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Carcinoma | X X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M M + + + + + + + + + + + + + + + + + M|
Adenoma | X X |
Carcinoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | X |
Polyp Stromal | X X X X X|
Sarcoma Stromal | |
Schwannoma Malignant | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X |
Fibroadenoma | X X X X |
Fibroma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 3| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 4| 3| 3| 8|
| 8| 5| 9| 5| 5| 9| 8| 5| 6| 5| 5| 4| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + I + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 4| 6| 7| 5| 7| 7| | |
DAY ON TEST | 8| 8| 3| 4| 3| 1| 3| 4| 3| 2| | |
| 8| 7| 4| 1| 0| 1| 5| 9| 5| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 17 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Adenoma | X | 6 |
Adenoma, Multiple | | 1 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Adenoma | X | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 4| 6| 7| 5| 7| 7| | |
DAY ON TEST | 8| 8| 3| 4| 3| 1| 3| 4| 3| 2| | |
| 8| 7| 4| 1| 0| 1| 5| 9| 5| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 3 |
Pars Distalis, Adenoma | X X X X X | 35 |
Pars Distalis, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Adenoma | | 1 |
C-Cell, Carcinoma | | 2 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + | 50 |
Adenoma | | 2 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Carcinoma | | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Leiomyoma | | 1 |
Polyp Stromal | | 6 |
Sarcoma Stromal | | 1 |
Schwannoma Malignant | | 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 16 |
__________________________________________________________________________|____________|
Thymus | M M + + + + M + + M | 52 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 4| 6| 7| 5| 7| 7| | |
DAY ON TEST | 8| 8| 3| 4| 3| 1| 3| 4| 3| 2| | |
| 8| 7| 4| 1| 0| 1| 5| 9| 5| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Adenocarcinoma | | 3 |
Fibroadenoma | X X | 7 |
Fibroma | X | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 16 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + | 39 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Urinary Bladder | M + + + + + + + + + | 59 |
Papilloma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 5| 5| 7| 4| 5| 7| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 7| 1| 4| 7| 0| 0| 9| 7| 3| 7| 6| 3| 8| 9|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 9| 4| 3| 9| 2| 7| 1| 4| 8| 8| 4| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + A + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + M + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Mesentery | |
Leukemia Mononuclear | |
Mesothelioma Benign | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + I + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 5| 5| 7| 4| 5| 7| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 7| 1| 4| 7| 0| 0| 9| 7| 3| 7| 6| 3| 8| 9|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 9| 4| 3| 9| 2| 7| 1| 4| 8| 8| 4| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Fibrosarcoma | |
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Benign | X |
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + M M + M + + + M M + + M + M +|
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X X |
Tunic, Mesothelioma Benign | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + A + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + M M +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + M + M + + + + + I +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + M +|
Fibroma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 5| 5| 7| 4| 5| 7| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 7| 1| 4| 7| 0| 0| 9| 7| 3| 7| 6| 3| 8| 9|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 9| 4| 3| 9| 2| 7| 1| 4| 8| 8| 4| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Lipoma | |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urethra | |
Transitional Epithelium, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + M +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Mesothelioma Benign | X |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 2| 6| 5| 5| 5| 6| 6| 6| 5| 7| 6| 6| 3| 6| 6| 6| 6| 5| 6| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 6| 0| 8| 8| 2| 9| 2| 8| 0| 3| 8| 2| 9| 5| 5| 2| 3| 6| 6| 7| 3| 9| 9| 4| 3|
| 4| 0| 2| 7| 7| 1| 6| 7| 2| 0| 0| 9| 9| 2| 1| 9| 6| 8| 8| 4| 4| 8| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + A A + + + + A + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + A + A A + + + + A + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + A + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + A + + + + + A + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Mesentery | + + + |
Leukemia Mononuclear | X |
Mesothelioma Benign | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + M|
Adenoma | X X X |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | M + I + + + + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | A + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 2| 6| 5| 5| 5| 6| 6| 6| 5| 7| 6| 6| 3| 6| 6| 6| 6| 5| 6| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 6| 0| 8| 8| 2| 9| 2| 8| 0| 3| 8| 2| 9| 5| 5| 2| 3| 6| 6| 7| 3| 9| 9| 4| 3|
| 4| 0| 2| 7| 7| 1| 6| 7| 2| 0| 0| 9| 9| 2| 1| 9| 6| 8| 8| 4| 4| 8| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
Fibrosarcoma | X |
Hemangiosarcoma | X |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + I + + + + A + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Benign | X |
__________________________________________________________________________|
Penis | + + + |
__________________________________________________________________________|
Preputial Gland | + + M + M + + + M + + + + + + + + M + + + + + + M|
Carcinoma | X |
__________________________________________________________________________|
Prostate | M + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | A + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X X |
Tunic, Mesothelioma Benign | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | A + + + + + + + + + + + + + + + + I + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Thymus | + + + M + M + + + M + M M + M + + M + M + + M + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M M + + + + + M + + +|
Fibroma | X |
__________________________________________________________________________|
Skin | + + + + + + M + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 2| 6| 5| 5| 5| 6| 6| 6| 5| 7| 6| 6| 3| 6| 6| 6| 6| 5| 6| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 6| 0| 8| 8| 2| 9| 2| 8| 0| 3| 8| 2| 9| 5| 5| 2| 3| 6| 6| 7| 3| 9| 9| 4| 3|
| 4| 0| 2| 7| 7| 1| 6| 7| 2| 0| 0| 9| 9| 2| 1| 9| 6| 8| 8| 4| 4| 8| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | A + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Lipoma | X |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urethra | |
Transitional Epithelium, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Mesothelioma Benign | X |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 7| 6| 5| 5| 6| 5| 6| | |
DAY ON TEST | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8| | |
| 0| 8| 2| 5| 6| 4| 4| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + M + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + | 52 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Leukemia Mononuclear | | 1 |
Mesothelioma Benign | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
Acinus, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + M + + + + + + + + | 58 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + M + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + M + + + + + + + + | 59 |
Squamous Cell Papilloma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + M + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 13 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Pheochromocytoma Benign | X X X | 15 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Adenoma | | 7 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + M M + + + + + + + | 54 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 7| 6| 5| 5| 6| 5| 6| | |
DAY ON TEST | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8| | |
| 0| 8| 2| 5| 6| 4| 4| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X X X X X X | 43 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 58 |
C-Cell, Adenoma | X | 3 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 4 |
Fibrosarcoma | | 1 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 58 |
Leukemia Mononuclear | | 1 |
Mesothelioma Benign | | 2 |
__________________________________________________________________________|____________|
Penis | + | 6 |
__________________________________________________________________________|____________|
Preputial Gland | M M M + + + M + + + | 44 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 58 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 58 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Adenoma | | 4 |
Tunic, Mesothelioma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + | 54 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 7| 6| 5| 5| 6| 5| 6| | |
DAY ON TEST | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8| | |
| 0| 8| 2| 5| 6| 4| 4| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + M | 45 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + | 54 |
Fibroma | X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Keratoacanthoma | | 1 |
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 60 |
Basal Cell Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Astrocytoma Malignant | | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
Lipoma | | 1 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
Transitional Epithelium, Carcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 7| 6| 5| 5| 6| 5| 6| | |
DAY ON TEST | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8| | |
| 0| 8| 2| 5| 6| 4| 4| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 9 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Mesothelioma Benign | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 3| 3| 6| 7| 6| 7| 6| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 6| 2| 0| 5| 0| 0| 6| 3| 7| 3| 5| 2| 1| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 0| 4| 9| 1| 1| 5| 4| 3| 5| 4| 0| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Fibrosarcoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pharynx | |
Papilloma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
Fibrosarcoma | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X |
Pheochromocytoma Benign, Multiple | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
Adenoma | X X X X |
Adenoma, Multiple | |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 3| 3| 6| 7| 6| 7| 6| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 6| 2| 0| 5| 0| 0| 6| 3| 7| 3| 5| 2| 1| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 0| 4| 9| 1| 1| 5| 4| 3| 5| 4| 0| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Fibrosarcoma | X |
Leukemia Mononuclear | |
Thoracic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | M + + + + + + + + + + + + M +|
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Axillary, Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Carcinoma, Metastatic | |
Mediastinal, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 3| 3| 6| 7| 6| 7| 6| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 6| 2| 0| 5| 0| 0| 6| 3| 7| 3| 5| 2| 1| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 0| 4| 9| 1| 1| 5| 4| 3| 5| 4| 0| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + I I + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + M + M + M M|
Fibroadenoma | |
Fibroma | X |
Sarcoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Other, Fibroma | |
Site of Application-Mass, Adenoma | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Papilloma | |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 3| 3| 6| 7| 6| 7| 6| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 6| 2| 0| 5| 0| 0| 6| 3| 7| 3| 5| 2| 1| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 0| 4| 9| 1| 1| 5| 4| 3| 5| 4| 0| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 5| 7| 6| 4| 7| 5| 5| 5| 6| 5| 7| 5| 5| 7| 4| 7| 7| 7| 5| 5| 5|
DAY ON TEST | 5| 5| 6| 8| 5| 0| 0| 8| 1| 4| 8| 9| 9| 1| 3| 5| 4| 1| 9| 2| 3| 1| 6| 9| 2|
| 9| 3| 5| 7| 6| 4| 1| 6| 8| 3| 4| 1| 2| 9| 5| 9| 2| 6| 0| 3| 4| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + A + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pharynx | +|
Papilloma | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X |
Pheochromocytoma Benign, Multiple | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Adenoma, Multiple | |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 5| 7| 6| 4| 7| 5| 5| 5| 6| 5| 7| 5| 5| 7| 4| 7| 7| 7| 5| 5| 5|
DAY ON TEST | 5| 5| 6| 8| 5| 0| 0| 8| 1| 4| 8| 9| 9| 1| 3| 5| 4| 1| 9| 2| 3| 1| 6| 9| 2|
| 9| 3| 5| 7| 6| 4| 1| 6| 8| 3| 4| 1| 2| 9| 5| 9| 2| 6| 0| 3| 4| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Fibrosarcoma | |
Leukemia Mononuclear | X |
Thoracic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + I + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + M + + + + + + M + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Axillary, Leukemia Mononuclear | X |
Deep Cervical, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Carcinoma, Metastatic | |
Mediastinal, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 5| 7| 6| 4| 7| 5| 5| 5| 6| 5| 7| 5| 5| 7| 4| 7| 7| 7| 5| 5| 5|
DAY ON TEST | 5| 5| 6| 8| 5| 0| 0| 8| 1| 4| 8| 9| 9| 1| 3| 5| 4| 1| 9| 2| 3| 1| 6| 9| 2|
| 9| 3| 5| 7| 6| 4| 1| 6| 8| 3| 4| 1| 2| 9| 5| 9| 2| 6| 0| 3| 4| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + M + I + + M + M + + + I + + + + + + + M M + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M M + + M + + M + + + + + + M + + + M + M|
Fibroadenoma | X |
Fibroma | |
Sarcoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Other, Fibroma | X |
Site of Application-Mass, Adenoma | X |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Papilloma | X |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 5| 7| 6| 4| 7| 5| 5| 5| 6| 5| 7| 5| 5| 7| 4| 7| 7| 7| 5| 5| 5|
DAY ON TEST | 5| 5| 6| 8| 5| 0| 0| 8| 1| 4| 8| 9| 9| 1| 3| 5| 4| 1| 9| 2| 3| 1| 6| 9| 2|
| 9| 3| 5| 7| 6| 4| 1| 6| 8| 3| 4| 1| 2| 9| 5| 9| 2| 6| 0| 3| 4| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6| | |
| 2| 4| 4| 9| 1| 3| 0| 4| 0| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + M + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 12 |
__________________________________________________________________________|____________|
Mesentery | | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Fibrosarcoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
Papilloma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Fibrosarcoma | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Squamous Cell Papilloma | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 8 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Adenoma | X | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X | 8 |
Pheochromocytoma Benign, Multiple | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6| | |
| 2| 4| 4| 9| 1| 3| 0| 4| 0| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Adenoma | X X X | 10 |
Adenoma, Multiple | X | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
Pars Distalis, Adenoma | X X X X X X X X | 41 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
C-Cell, Adenoma | | 2 |
C-Cell, Carcinoma | X | 1 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
Fibrosarcoma | | 1 |
Leukemia Mononuclear | | 1 |
Thoracic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 46 |
Adenoma | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Interstitial Cell, Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Axillary, Leukemia Mononuclear | | 1 |
Deep Cervical, Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6| | |
| 2| 4| 4| 9| 1| 3| 0| 4| 0| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Leukemia Mononuclear | | 1 |
Mediastinal, Carcinoma, Metastatic | X | 1 |
Mediastinal, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 12 |
__________________________________________________________________________|____________|
Thymus | + M + I + + + + + M | 37 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 38 |
Fibroadenoma | | 1 |
Fibroma | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 56 |
Keratoacanthoma | | 1 |
Other, Fibroma | | 1 |
Site of Application-Mass, Adenoma | | 1 |
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Carcinoma, Metastatic | X | 1 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Carcinoma, Metastatic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6| | |
| 2| 4| 4| 9| 1| 3| 0| 4| 0| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Papilloma | | 1 |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + | 43 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 3 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 56 |
Leukemia Mononuclear | X X | 12 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 4| 7| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 6| 3| 3| 5| 3| 3| 3| 0| 3| 4| 5| 4| 2| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 5| 7| 7| 5| 9| 5| 5| 5| 8| 8| 5| 4| 7| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Mesentery | +|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + + + +|
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
Adenoma | X X X X|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 4| 7| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 6| 3| 3| 5| 3| 3| 3| 0| 3| 4| 5| 4| 2| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 5| 7| 7| 5| 9| 5| 5| 5| 8| 8| 5| 4| 7| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Fibroma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + M + + + + M + + + + M|
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| |
Interstitial Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + A + + + + + + + + I + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
Sarcoma | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M A + + M + + + M + + + M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + M + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Face, Papilloma | |
Lip, Papilloma | |
Thoracic, Keratoacanthoma | X |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 4| 7| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 6| 3| 3| 5| 3| 3| 3| 0| 3| 4| 5| 4| 2| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 5| 7| 7| 5| 9| 5| 5| 5| 8| 8| 5| 4| 7| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + M + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + |
Papilloma | X X |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + M + + + + + + + + + +|
Carcinoma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 7| 7| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 6| 5| 6| 6| 6| 5| 6| 3|
DAY ON TEST | 6| 9| 8| 4| 3| 1| 4| 5| 8| 9| 0| 1| 9| 2| 1| 3| 0| 6| 2| 3| 0| 1| 3| 5| 9|
| 2| 6| 9| 9| 4| 8| 2| 0| 2| 9| 0| 9| 9| 6| 2| 2| 8| 5| 8| 7| 7| 5| 4| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + A + + + + + + A A A + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + A A + + + A|
Adenocarcinoma | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + A A A + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + A + + + + + + A A A A A + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + A + + + + + + A A A A A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Squamous Cell Papilloma | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Carcinoma, Metastatic | |
__________________________________________________________________________|
Pituitary Gland | + + + + I + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 7| 7| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 6| 5| 6| 6| 6| 5| 6| 3|
DAY ON TEST | 6| 9| 8| 4| 3| 1| 4| 5| 8| 9| 0| 1| 9| 2| 1| 3| 0| 6| 2| 3| 0| 1| 3| 5| 9|
| 2| 6| 9| 9| 4| 8| 2| 0| 2| 9| 0| 9| 9| 6| 2| 2| 8| 5| 8| 7| 7| 5| 4| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Fibroma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Carcinoma | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X |
Interstitial Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X X X X X X |
Sarcoma | X |
__________________________________________________________________________|
Thymus | + + + M M + M + + + + I + + + + + I + + M M M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Face, Papilloma | X |
Lip, Papilloma | X |
Thoracic, Keratoacanthoma | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 7| 7| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 6| 5| 6| 6| 6| 5| 6| 3|
DAY ON TEST | 6| 9| 8| 4| 3| 1| 4| 5| 8| 9| 0| 1| 9| 2| 1| 3| 0| 6| 2| 3| 0| 1| 3| 5| 9|
| 2| 6| 9| 9| 4| 8| 2| 0| 2| 9| 0| 9| 9| 6| 2| 2| 8| 5| 8| 7| 7| 5| 4| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Papilloma | |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 5| 6| 6| 5| 5| 5| | |
DAY ON TEST | 6| 8| 3| 2| 3| 4| 1| 3| 8| 6| | |
| 8| 6| 4| 8| 5| 1| 2| 4| 0| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A A + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + | 53 |
Adenocarcinoma | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + M + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hepatocellular Adenoma | X | 1 |
Leukemia Mononuclear | X X | 13 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Squamous Cell Papilloma | | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 57 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 49 |
Adenoma | X | 7 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + | 57 |
Carcinoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 5| 6| 6| 5| 5| 5| | |
DAY ON TEST | 6| 8| 3| 2| 3| 4| 1| 3| 8| 6| | |
| 8| 6| 4| 8| 5| 1| 2| 4| 0| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 2 |
Pars Distalis, Adenoma | X X X X X X X X | 46 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + + + + | 57 |
C-Cell, Adenoma | | 2 |
C-Cell, Carcinoma | | 2 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Fibroma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + M + | 54 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 58 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
Bilateral, Interstitial Cell, Adenoma| | 1 |
Interstitial Cell, Adenoma | | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Leukemia Mononuclear | X X | 13 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + + + M + + | 52 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Face, Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05106-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/04/97
Route: SKIN APPLICATION Time: 09:03:54
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 5| 6| 6| 5| 5| 5| | |
DAY ON TEST | 6| 8| 3| 2| 3| 4| 1| 3| 8| 6| | |
| 8| 6| 4| 8| 5| 1| 2| 4| 0| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Lip, Papilloma | | 1 |
Thoracic, Keratoacanthoma | | 1 |
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X | 12 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
Adenoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
Papilloma | | 2 |
__________________________________________________________________________|____________|
Eye | + + + + + + + + | 42 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 56 |
Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
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---------- END OF REPORT ----------
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