TDMS Study 05106-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Hazelton, MD DIETHYLPHTHALATE DATE: 05/19/95
EXPERIMENT: 05106 TEST: 01 TIME: 20:59:37
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1ES45036 ROUTE: SKIN APPLICATION NTP C#: 60048B
PATHOLOGIST: R. CARDY CAS: 84-66-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Hazelton, MD DIETHYLPHTHALATE DATE: 05/19/95
EXPERIMENT: 05106 TEST: 01 TIME: 20:59:37
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1ES45036 ROUTE: SKIN APPLICATION NTP C#: 60048B
PATHOLOGIST: R. CARDY CAS: 84-66-2
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Gland
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Hazelton, MD DIETHYLPHTHALATE DATE: 05/19/95
EXPERIMENT: 05106 TEST: 01 TIME: 20:59:37
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1ES45036 ROUTE: SKIN APPLICATION NTP C#: 60048B
PATHOLOGIST: R. CARDY CAS: 84-66-2
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF DIETHYLPHTHALATE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
All Organs Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Uterus Polyp Stromal
Sarcoma Stromal or Polyp Stromal
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 1/50 (2%) 0/59 (0%) | 4/60 (7%) 4/50 (8%) 7/60 (12%) |
|ADJUSTED (b) | 0.0% 16.7% 0.0% | 12.8% 12.7% 25.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/0 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 1/6 (17%) 0/6 (0%) | 3/30 (10%) 3/28 (11%) 4/23 (17%) |
|FIRST INCIDENCE (DAYS) | --- 734 (T) --- | 730 567 559 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.658N P=0.581 (e) | P=0.099 P=0.607 P=0.143 |
|INCIDENTAL TUMOR | P=0.658N P=0.581 (e) | P=0.122 P=0.614 P=0.163 |
|LOGISTIC REGRESSION | P=0.658N P=0.581 (e) | P=0.126 P=0.594 P=0.165 |
|COCHRAN-ARMITAGE | P=0.695N | P=0.217 |
|FISHER EXACT | P=0.459 (e) | P=0.536 P=0.264 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/59 (25%) 9/50 (18%) 8/57 (14%) | 3/59 (5%) 1/50 (2%) 1/60 (2%) |
|ADJUSTED (b) | 76.2% 61.3% 50.0% | 10.0% 3.6% 4.3% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/0 0/9 (0%) | 0/9 (0%) 0/0 0/10 (0%) |
|TERMINAL (d) | 2/4 (50%) 2/6 (33%) 1/6 (17%) | 3/30 (10%) 1/28 (4%) 1/23 (4%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 616 534 | 734 (T) 734 (T) 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.039N* P=0.052N P=0.032N* | P=0.354N P=0.329N P=0.403N |
|INCIDENTAL TUMOR | P=0.076N P=0.098N P=0.088N | P=0.354N P=0.329N P=0.403N |
|LOGISTIC REGRESSION | P=0.058N P=0.088N P=0.056N | P=0.354N P=0.329N P=0.403N |
|COCHRAN-ARMITAGE | P=0.092N | P=0.261N |
|FISHER EXACT | P=0.243N P=0.095N | P=0.374N P=0.303N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/59 (25%) 10/50 (20%) 9/57 (16%) | 4/59 (7%) 2/50 (4%) 1/60 (2%) |
|ADJUSTED (b) | 76.2% 62.3% 60.0% | 13.3% 5.7% 4.3% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/0 0/9 (0%) | 0/9 (0%) 0/0 0/10 (0%) |
|TERMINAL (d) | 2/4 (50%) 2/6 (33%) 2/6 (33%) | 4/30 (13%) 1/28 (4%) 1/23 (4%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 580 534 | 734 (T) 551 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.060N P=0.084N P=0.048N* | P=0.217N P=0.367N P=0.265N |
|INCIDENTAL TUMOR | P=0.117N P=0.158N P=0.124N | P=0.191N P=0.364N P=0.265N |
|LOGISTIC REGRESSION | P=0.090N P=0.145N P=0.086N | P=0.193N P=0.381N P=0.265N |
|COCHRAN-ARMITAGE | P=0.136N | P=0.144N |
|FISHER EXACT | P=0.330N P=0.147N | P=0.421N P=0.177N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/44 (0%) 1/46 (2%) 0/54 (0%) | 5/53 (9%) 0/39 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 16.7% 0.0% | 15.2% 0.0% 8.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/0 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 1/6 (17%) 0/6 (0%) | 3/29 (10%) 0/28 (0%) 2/23 (9%) |
|FIRST INCIDENCE (DAYS) | --- 734 (T) --- | 650 --- 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.658N P=0.581 (e) | P=0.325N P=0.042N* P=0.330N |
|INCIDENTAL TUMOR | P=0.658N P=0.581 (e) | P=0.355N P=0.045N* P=0.367N |
|LOGISTIC REGRESSION | P=0.658N P=0.581 (e) | P=0.311N P=0.044N* P=0.315N |
|COCHRAN-ARMITAGE | P=0.670N | P=0.244N |
|FISHER EXACT | P=0.511 (e) | P=0.058N P=0.243N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/44 (2%) 1/46 (2%) 2/54 (4%) | 2/53 (4%) 1/39 (3%) 2/50 (4%) |
|ADJUSTED (b) | 2.5% 5.6% 5.9% | 6.9% 3.6% 8.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/0 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 0/6 (0%) | 2/29 (7%) 1/28 (4%) 2/23 (9%) |
|FIRST INCIDENCE (DAYS) | 549 666 542 | 734 (T) 734 (T) 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.392 P=0.742N P=0.501 | P=0.509 P=0.512N P=0.610 |
|INCIDENTAL TUMOR | P=0.499 P=0.725N P=0.656 | P=0.509 P=0.512N P=0.610 |
|LOGISTIC REGRESSION | P=0.464 P=0.759N P=0.562 | P=0.509 P=0.512N P=0.610 |
|COCHRAN-ARMITAGE | P=0.465 | P=0.591 |
|FISHER EXACT | P=0.742N P=0.577 | P=0.614N P=0.669 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/44 (2%) 2/46 (4%) 2/54 (4%) | 7/53 (13%) 1/39 (3%) 4/50 (8%) |
|ADJUSTED (b) | 2.5% 21.3% 5.9% | 21.7% 3.6% 17.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/0 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 1/6 (17%) 0/6 (0%) | 5/29 (17%) 1/28 (4%) 4/23 (17%) |
|FIRST INCIDENCE (DAYS) | 549 666 542 | 650 734 (T) 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.474 P=0.565 P=0.501 | P=0.452N P=0.040N* P=0.415N |
|INCIDENTAL TUMOR | P=0.573 P=0.583 P=0.656 | P=0.478N P=0.043N* P=0.449N |
|LOGISTIC REGRESSION | P=0.531 P=0.559 P=0.562 | P=0.446N P=0.043N* P=0.411N |
|COCHRAN-ARMITAGE | P=0.532 | P=0.323N |
|FISHER EXACT | P=0.517 P=0.577 | P=0.074N P=0.298N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Ear |
| Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/50 (2%) 2/60 (3%) | 0/60 (0%) 0/52 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 9.1% 20.1% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 1/6 (17%) | 0/30 (0%) 0/28 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | --- 704 645 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.239 P=0.621 P=0.312 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.212 P=0.547 P=0.306 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.201 P=0.560 P=0.278 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.189 | (e) |
|FISHER EXACT | P=0.455 P=0.248 | (e) (e) |
|=================================================================================================================================|
| |
|Intestine Large: Colon/Rectum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 2/60 (3%) | 0/60 (0%) 0/52 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 11.2% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 0/6 (0%) | 0/30 (0%) 0/28 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 534 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.119 (e) P=0.311 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.144 (e) P=0.315 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.100 (e) P=0.245 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.101 | (e) |
|FISHER EXACT | (e) P=0.248 | (e) (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 11/50 (22%) 7/49 (14%) | 3/50 (6%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | 49.4% 78.0% 41.1% | 9.2% 3.6% 13.0% |
|INTERIM SACRIFICE 1 (c)| 1/1 (100%) 0/0 0/0 | 0/0 0/0 0/0 |
|TERMINAL (d) | 1/4 (25%) 4/6 (67%) 1/6 (17%) | 2/30 (7%) 1/28 (4%) 3/23 (13%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 620 533 | 679 734 (T) 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.416N P=0.343 P=0.562N | P=0.422 P=0.341N P=0.534 |
|INCIDENTAL TUMOR | P=0.494N P=0.242 P=0.536 | P=0.423 P=0.325N P=0.539 |
|LOGISTIC REGRESSION | P=0.412N P=0.320 P=0.583N | P=0.427 P=0.333N P=0.544 |
|COCHRAN-ARMITAGE | P=0.496N | P=0.541 |
|FISHER EXACT | P=0.218 P=0.597 | P=0.309N P=0.661N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/49 (0%) | 2/50 (4%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 10.0% 0.0% | 6.7% 10.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/0 0/0 0/0 |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 0/6 (0%) | 2/30 (7%) 3/28 (11%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | --- 716 --- | 734 (T) 734 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.650N P=0.638 (e) | P=0.226N P=0.468 P=0.298N |
|INCIDENTAL TUMOR | P=0.686N P=0.547 (e) | P=0.226N P=0.468 P=0.298N |
|LOGISTIC REGRESSION | P=0.668N P=0.573 (e) | P=0.226N P=0.468 P=0.298N |
|COCHRAN-ARMITAGE | P=0.708N | P=0.165N |
|FISHER EXACT | P=0.500 (e) | P=0.500 P=0.247N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 12/50 (24%) 7/49 (14%) | 5/50 (10%) 4/50 (8%) 3/50 (6%) |
|ADJUSTED (b) | 49.4% 80.2% 41.1% | 15.7% 14.3% 13.0% |
|INTERIM SACRIFICE 1 (c)| 1/1 (100%) 0/0 0/0 | 0/0 0/0 0/0 |
|TERMINAL (d) | 1/4 (25%) 4/6 (67%) 1/6 (17%) | 4/30 (13%) 4/28 (14%) 3/23 (13%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 620 533 | 679 734 (T) 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.382N P=0.287 P=0.562N | P=0.463N P=0.551N P=0.509N |
|INCIDENTAL TUMOR | P=0.464N P=0.176 P=0.536 | P=0.461N P=0.539N P=0.505N |
|LOGISTIC REGRESSION | P=0.383N P=0.246 P=0.583N | P=0.469N P=0.566N P=0.508N |
|COCHRAN-ARMITAGE | P=0.474N | P=0.315N |
|FISHER EXACT | P=0.154 P=0.597 | P=0.500N P=0.357N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/60 (2%) | 2/59 (3%) 0/50 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 12.5% | 6.7% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/0 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 0/6 (0%) | 2/30 (7%) 0/28 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 722 | 734 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.359 (e) P=0.594 | P=0.206N P=0.253N P=0.298N |
|INCIDENTAL TUMOR | P=0.314 (e) P=0.536 | P=0.206N P=0.253N P=0.298N |
|LOGISTIC REGRESSION | P=0.337 (e) P=0.579 | P=0.206N P=0.253N P=0.298N |
|COCHRAN-ARMITAGE | P=0.306 | P=0.170N |
|FISHER EXACT | (e) P=0.500 | P=0.291N P=0.244N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/60 (0%) | 5/60 (8%) 3/52 (6%) 3/60 (5%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 15.1% 9.0% 13.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 0/6 (0%) | 4/30 (13%) 1/28 (4%) 3/23 (13%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 465 645 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.469N P=0.397N P=0.492N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.414N P=0.335N P=0.413N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.403N P=0.415N P=0.443N |
|COCHRAN-ARMITAGE | (e) | P=0.327N |
|FISHER EXACT | (e) (e) | P=0.441N P=0.359N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/60 (0%) | 6/60 (10%) 3/52 (6%) 3/60 (5%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 17.8% 9.0% 13.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 0/6 (0%) | 4/30 (13%) 1/28 (4%) 3/23 (13%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 465 645 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.359N P=0.285N P=0.377N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.305N P=0.225N P=0.300N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.297N P=0.293N P=0.327N |
|COCHRAN-ARMITAGE | (e) | P=0.227N |
|FISHER EXACT | (e) (e) | P=0.321N P=0.245N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/50 (2%) 0/60 (0%) | 23/60 (38%) 12/52 (23%) 7/60 (12%) |
|ADJUSTED (b) | 0.0% 2.9% 0.0% | 59.9% 36.8% 24.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 2/9 (22%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 0/6 (0%) | 16/30 (53%) 8/28 (29%) 4/23 (17%) |
|FIRST INCIDENCE (DAYS) | --- 597 --- | 331 650 585 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.702N P=0.532 (e) | P=0.006N** P=0.065N P=0.006N** |
|INCIDENTAL TUMOR | P=0.769N P=0.449 (e) | P=0.003N** P=0.070N P=0.002N** |
|LOGISTIC REGRESSION | P=0.694N P=0.458 (e) | P=0.002N** P=0.042N* P=0.001N** |
|COCHRAN-ARMITAGE | P=0.694N | P<0.001N** |
|FISHER EXACT | P=0.455 (e) | P=0.062N P<0.001N** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/50 (2%) 0/60 (0%) | 0/60 (0%) 0/52 (0%) 1/60 (2%) |
|ADJUSTED (b) | 10.4% 16.7% 0.0% | 0.0% 0.0% 2.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 1/6 (17%) 0/6 (0%) | 0/30 (0%) 0/28 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | 520 734 (T) --- | --- --- 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.146N P=0.428N P=0.215N | P=0.280 (e) P=0.478 |
|INCIDENTAL TUMOR | P=0.120N P=0.459N P=0.170N | P=0.370 (e) P=0.581 |
|LOGISTIC REGRESSION | P=0.165N P=0.498N P=0.235N | P=0.342 (e) P=0.527 |
|COCHRAN-ARMITAGE | P=0.175N | P=0.304 |
|FISHER EXACT | P=0.569N P=0.248N | (e) P=0.500 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/50 (4%) 0/60 (0%) | 24/60 (40%) 12/52 (23%) 8/60 (13%) |
|ADJUSTED (b) | 10.4% 19.1% 0.0% | 61.1% 36.8% 26.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 2/9 (22%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 1/6 (17%) 0/6 (0%) | 16/30 (53%) 8/28 (29%) 4/23 (17%) |
|FIRST INCIDENCE (DAYS) | 520 597 --- | 331 650 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.145N P=0.621N P=0.215N | P=0.010N** P=0.047N* P=0.009N** |
|INCIDENTAL TUMOR | P=0.141N P=0.685N P=0.170N | P=0.003N** P=0.048N* P=0.002N** |
|LOGISTIC REGRESSION | P=0.164N P=0.680 P=0.235N | P=0.002N** P=0.028N* P=0.002N** |
|COCHRAN-ARMITAGE | P=0.170N | P=0.001N** |
|FISHER EXACT | P=0.619 P=0.248N | P=0.043N* P<0.001N** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/50 (4%) 0/60 (0%) | 27/60 (45%) 14/52 (27%) 11/60 (18%) |
|ADJUSTED (b) | 10.4% 19.1% 0.0% | 67.4% 41.6% 37.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 2/9 (22%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 1/6 (17%) 0/6 (0%) | 18/30 (60%) 9/28 (32%) 7/23 (30%) |
|FIRST INCIDENCE (DAYS) | 520 597 --- | 331 645 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.145N P=0.621N P=0.215N | P=0.020N* P=0.039N* P=0.016N* |
|INCIDENTAL TUMOR | P=0.141N P=0.685N P=0.170N | P=0.006N** P=0.031N* P=0.003N** |
|LOGISTIC REGRESSION | P=0.164N P=0.680 P=0.235N | P=0.004N** P=0.023N* P=0.003N** |
|COCHRAN-ARMITAGE | P=0.170N | P=0.002N** |
|FISHER EXACT | P=0.619 P=0.248N | P=0.037N* P=0.001N** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 43/54 (80%) 41/49 (84%) 46/58 (79%) | 42/59 (71%) 33/50 (66%) 35/58 (60%) |
|ADJUSTED (b) | 100.0% 96.9% 100.0% | 88.7% 76.0% 94.0% |
|INTERIM SACRIFICE 1 (c)| 4/10 (40%) 0/0 5/9 (56%) | 4/9 (44%) 0/1 (0%) 2/10 (20%) |
|TERMINAL (d) | 3/3 (100%) 5/6 (83%) 5/5 (100%) | 25/30 (83%) 18/28 (64%) 21/23 (91%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 304 391 | 456 (I) 434 430 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.440N P=0.219N P=0.388N | P=0.460 P=0.356N P=0.523 |
|INCIDENTAL TUMOR | P=0.554N P=0.333N P=0.555N | P=0.305N P=0.197N P=0.289N |
|LOGISTIC REGRESSION | P=0.517N P=0.525 P=0.566N | P=0.283N P=0.299N P=0.292N |
|COCHRAN-ARMITAGE | P=0.496N | P=0.137N |
|FISHER EXACT | P=0.393 P=0.577N | P=0.353N P=0.149N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/54 (0%) 0/49 (0%) 1/58 (2%) | 2/59 (3%) 2/50 (4%) 1/58 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 2.6% | 5.7% 5.9% 4.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/1 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/3 (0%) 0/6 (0%) 0/5 (0%) | 0/30 (0%) 1/28 (4%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 549 | 679 573 729 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.285 (e) P=0.490 | P=0.492N P=0.661 P=0.602N |
|INCIDENTAL TUMOR | P=0.252 (e) P=0.439 | P=0.473N P=0.669 P=0.630N |
|LOGISTIC REGRESSION | P=0.321 (e) P=0.512 | P=0.449N P=0.645 P=0.579N |
|COCHRAN-ARMITAGE | P=0.314 | P=0.401N |
|FISHER EXACT | (e) P=0.518 | P=0.626 P=0.506N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 43/54 (80%) 41/49 (84%) 47/58 (81%) | 44/59 (75%) 35/50 (70%) 36/58 (62%) |
|ADJUSTED (b) | 100.0% 96.9% 100.0% | 89.4% 78.9% 94.2% |
|INTERIM SACRIFICE 1 (c)| 4/10 (40%) 0/0 5/9 (56%) | 4/9 (44%) 0/1 (0%) 2/10 (20%) |
|TERMINAL (d) | 3/3 (100%) 5/6 (83%) 5/5 (100%) | 25/30 (83%) 19/28 (68%) 21/23 (91%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 304 391 | 456 (I) 434 430 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.491N P=0.219N P=0.434N | P=0.504 P=0.370N P=0.558 |
|INCIDENTAL TUMOR | P=0.457 P=0.333N P=0.531 | P=0.245N P=0.194N P=0.252N |
|LOGISTIC REGRESSION | P=0.509 P=0.525 P=0.537 | P=0.216N P=0.310N P=0.231N |
|COCHRAN-ARMITAGE | P=0.528 | P=0.090N |
|FISHER EXACT | P=0.393 P=0.520 | P=0.375N P=0.104N |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/50 (4%) 3/60 (5%) | 0/60 (0%) 0/52 (0%) 0/60 (0%) |
|ADJUSTED (b) | 12.3% 18.7% 25.2% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 1/6 (17%) 1/6 (17%) | 0/30 (0%) 0/28 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | 598 553 512 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.502 P=0.605N P=0.623 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.463 P=0.684N P=0.572 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.444 P=0.695 P=0.532 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.437 | (e) |
|FISHER EXACT | P=0.619 P=0.500 | (e) (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Skin |
| Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 2/60 (3%) | 0/60 (0%) 0/52 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 10.3% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 0/6 (0%) | 0/30 (0%) 0/28 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 512 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.111 (e) P=0.303 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.144 (e) P=0.315 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.101 (e) P=0.241 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.101 | (e) |
|FISHER EXACT | (e) P=0.248 | (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/50 (2%) 3/60 (5%) | 0/60 (0%) 0/52 (0%) 0/60 (0%) |
|ADJUSTED (b) | 3.6% 2.4% 25.2% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 1/6 (17%) | 0/30 (0%) 0/28 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | 598 553 512 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.239 P=0.734N P=0.407 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.213 P=0.704 P=0.362 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.213 P=0.700 P=0.324 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.214 | (e) |
|FISHER EXACT | P=0.705 P=0.309 | (e) (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/50 (2%) 3/60 (5%) | 0/60 (0%) 0/52 (0%) 0/60 (0%) |
|ADJUSTED (b) | 3.6% 2.4% 25.2% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 1/6 (17%) | 0/30 (0%) 0/28 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | 598 553 512 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.239 P=0.734N P=0.407 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.213 P=0.704 P=0.362 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.213 P=0.700 P=0.324 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.214 | (e) |
|FISHER EXACT | P=0.705 P=0.309 | (e) (e) |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/50 (4%) 3/60 (5%) | 0/60 (0%) 0/52 (0%) 1/60 (2%) |
|ADJUSTED (b) | 7.6% 5.3% 11.5% | 0.0% 0.0% 3.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 0/6 (0%) | 0/30 (0%) 0/28 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | 594 560 413 | --- --- 675 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.448 P=0.659N P=0.563 | P=0.262 (e) P=0.451 |
|INCIDENTAL TUMOR | P=0.333 P=0.601 P=0.438 | P=0.257 (e) P=0.455 |
|LOGISTIC REGRESSION | P=0.435 P=0.614 P=0.498 | P=0.288 (e) P=0.483 |
|COCHRAN-ARMITAGE | P=0.437 | P=0.304 |
|FISHER EXACT | P=0.619 P=0.500 | (e) P=0.500 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 3/50 (6%) 9/59 (15%) | |
|ADJUSTED (b) | 34.7% 30.8% 69.1% | |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | |
|TERMINAL (d) | 1/4 (25%) 1/6 (17%) 3/6 (50%) | |
|FIRST INCIDENCE (DAYS) | 578 701 519 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.124 P=0.319N P=0.283 | |
|INCIDENTAL TUMOR | P=0.070 P=0.422N P=0.161 | |
|LOGISTIC REGRESSION | P=0.068 P=0.399N P=0.167 | |
|COCHRAN-ARMITAGE | P=0.061 | |
|FISHER EXACT | P=0.601N P=0.113 | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/58 (5%) 2/50 (4%) 2/57 (4%) | 0/59 (0%) 0/50 (0%) 1/60 (2%) |
|ADJUSTED (b) | 14.1% 10.9% 6.0% | 0.0% 0.0% 4.3% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/0 0/9 (0%) | 0/9 (0%) 0/0 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 0/6 (0%) | 0/30 (0%) 0/28 (0%) 1/23 (4%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 665 542 | --- --- 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.424N P=0.618N P=0.470N | P=0.254 (e) P=0.447 |
|INCIDENTAL TUMOR | P=0.451N P=0.655N P=0.546N | P=0.254 (e) P=0.447 |
|LOGISTIC REGRESSION | P=0.454N P=0.547N P=0.512N | P=0.254 (e) P=0.447 |
|COCHRAN-ARMITAGE | P=0.455N | P=0.308 |
|FISHER EXACT | P=0.571N P=0.508N | (e) P=0.504 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/58 (0%) 1/50 (2%) 2/57 (4%) | 6/59 (10%) 5/50 (10%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 4.0% 7.1% | 18.9% 14.8% 7.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/0 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 0/6 (0%) | 5/30 (17%) 3/28 (11%) 1/23 (4%) |
|FIRST INCIDENCE (DAYS) | --- 652 538 | 656 494 675 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.173 P=0.577 P=0.254 | P=0.186N P=0.543N P=0.231N |
|INCIDENTAL TUMOR | P=0.235 P=0.547 P=0.311 | P=0.137N P=0.493N P=0.229N |
|LOGISTIC REGRESSION | P=0.182 P=0.510 P=0.234 | P=0.140N P=0.575N P=0.208N |
|COCHRAN-ARMITAGE | P=0.182 | P=0.100N |
|FISHER EXACT | P=0.463 P=0.243 | P=0.616N P=0.131N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/58 (5%) 3/50 (6%) 4/57 (7%) | 6/59 (10%) 5/50 (10%) 3/60 (5%) |
|ADJUSTED (b) | 14.1% 14.5% 12.8% | 18.9% 14.8% 11.8% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/0 0/9 (0%) | 0/9 (0%) 0/0 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 0/6 (0%) | 5/30 (17%) 3/28 (11%) 2/23 (9%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 652 538 | 656 494 675 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.468 P=0.605 P=0.535 | P=0.325N P=0.543N P=0.382N |
|INCIDENTAL TUMOR | P=0.484 P=0.564 P=0.509 | P=0.260N P=0.493N P=0.381N |
|LOGISTIC REGRESSION | P=0.439 P=0.629 P=0.486 | P=0.262N P=0.575N P=0.359N |
|COCHRAN-ARMITAGE | P=0.438 | P=0.188N |
|FISHER EXACT | P=0.588 P=0.490 | P=0.616N P=0.237N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/58 (2%) 1/50 (2%) 1/57 (2%) | 3/59 (5%) 1/50 (2%) 1/60 (2%) |
|ADJUSTED (b) | 25.0% 7.7% 5.9% | 7.3% 3.6% 2.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/0 0/10 (0%) |
|TERMINAL (d) | 1/4 (25%) 0/6 (0%) 0/6 (0%) | 1/30 (3%) 1/28 (4%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 701 667 | 465 734 (T) 569 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.622N P=0.643N P=0.709N | P=0.320N P=0.326N P=0.352N |
|INCIDENTAL TUMOR | P=0.629N P=0.688N P=0.694N | P=0.195N P=0.260N P=0.174N |
|LOGISTIC REGRESSION | P=0.637N P=0.685N P=0.713N | P=0.225N P=0.408N P=0.250N |
|COCHRAN-ARMITAGE | P=0.674N | P=0.261N |
|FISHER EXACT | P=0.714 P=0.748 | P=0.374N P=0.303N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/58 (3%) 1/50 (2%) 1/57 (2%) | 3/59 (5%) 1/50 (2%) 1/60 (2%) |
|ADJUSTED (b) | 28.9% 7.7% 5.9% | 7.3% 3.6% 2.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/0 0/10 (0%) |
|TERMINAL (d) | 1/4 (25%) 0/6 (0%) 0/6 (0%) | 1/30 (3%) 1/28 (4%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | 646 701 667 | 465 734 (T) 569 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.384N P=0.353N P=0.430N | P=0.320N P=0.326N P=0.352N |
|INCIDENTAL TUMOR | P=0.384N P=0.399N P=0.411N | P=0.195N P=0.260N P=0.174N |
|LOGISTIC REGRESSION | P=0.403N P=0.413N P=0.446N | P=0.225N P=0.408N P=0.250N |
|COCHRAN-ARMITAGE | P=0.444N | P=0.261N |
|FISHER EXACT | P=0.556N P=0.507N | P=0.374N P=0.303N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 2/60 (3%) 3/52 (6%) 6/60 (10%) |
|ADJUSTED (b) | | 6.7% 10.7% 21.7% |
|INTERIM SACRIFICE 1 (c)| | 0/9 (0%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | | 2/30 (7%) 3/28 (11%) 4/23 (17%) |
|FIRST INCIDENCE (DAYS) | | 734 (T) 734 (T) 367 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.043 * P=0.468 P=0.074 |
|INCIDENTAL TUMOR | | P=0.054 P=0.468 P=0.100 |
|LOGISTIC REGRESSION | | P=0.045 * P=0.468 P=0.072 |
|COCHRAN-ARMITAGE | | P=0.103 |
|FISHER EXACT | | P=0.432 P=0.136 |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 2/60 (3%) 3/52 (6%) 7/60 (12%) |
|ADJUSTED (b) | | 6.7% 10.7% 23.4% |
|INTERIM SACRIFICE 1 (c)| | 0/9 (0%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | | 2/30 (7%) 3/28 (11%) 4/23 (17%) |
|FIRST INCIDENCE (DAYS) | | 734 (T) 734 (T) 367 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.020 * P=0.468 P=0.043 * |
|INCIDENTAL TUMOR | | P=0.033 * P=0.468 P=0.078 |
|LOGISTIC REGRESSION | | P=0.027 * P=0.468 P=0.068 |
|COCHRAN-ARMITAGE | | P=0.055 |
|FISHER EXACT | | P=0.432 P=0.081 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 9/60 (15%) 12/50 (24%) 13/60 (22%) | 18/60 (30%) 15/52 (29%) 17/60 (28%) |
|ADJUSTED (b) | 65.1% 77.9% 53.1% | 40.4% 38.1% 45.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 1/9 (11%) 0/2 (0%) 1/10 (10%) |
|TERMINAL (d) | 2/4 (50%) 4/6 (67%) 1/6 (17%) | 6/30 (20%) 6/28 (21%) 5/23 (22%) |
|FIRST INCIDENCE (DAYS) | 520 490 413 | 456 (I) 545 344 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.382 P=0.579 P=0.391 | P=0.359 P=0.483N P=0.410 |
|INCIDENTAL TUMOR | P=0.323 P=0.394 P=0.266 | P=0.479N P=0.363N P=0.472N |
|LOGISTIC REGRESSION | P=0.278 P=0.338 P=0.263 | P=0.481N P=0.316N P=0.507N |
|COCHRAN-ARMITAGE | P=0.275 | P=0.477N |
|FISHER EXACT | P=0.170 P=0.240 | P=0.530N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 0/60 (0%) | 0/60 (0%) 0/52 (0%) 0/60 (0%) |
|ADJUSTED (b) | 14.6% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 0/6 (0%) | 0/30 (0%) 0/28 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | 548 --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.142N P=0.185N P=0.187N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.190N P=0.240N P=0.267N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.168N P=0.254N P=0.229N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.172N | (e) |
|FISHER EXACT | P=0.295N P=0.248N | (e) (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 0/60 (0%) | 0/60 (0%) 0/52 (0%) 0/60 (0%) |
|ADJUSTED (b) | 14.6% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 0/6 (0%) | 0/30 (0%) 0/28 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | 548 --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.142N P=0.185N P=0.187N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.190N P=0.240N P=0.267N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.168N P=0.254N P=0.229N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.172N | (e) |
|FISHER EXACT | P=0.295N P=0.248N | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/50 (2%) 0/60 (0%) | 0/60 (0%) 0/52 (0%) 0/60 (0%) |
|ADJUSTED (b) | 6.4% 2.0% 0.0% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 0/9 (0%) 0/2 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/4 (0%) 0/6 (0%) 0/6 (0%) | 0/30 (0%) 0/28 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | 528 304 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.166N P=0.493N P=0.219N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.218N P=0.485N P=0.230N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.197N P=0.686N P=0.240N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.175N | (e) |
|FISHER EXACT | P=0.569N P=0.248N | (e) (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 51/60 (85%) 47/50 (94%) 52/60 (87%) | 53/60 (88%) 41/52 (79%) 41/60 (68%) |
|ADJUSTED (b) | 100.0% 100.0% 98.0% | 98.1% 90.9% 94.9% |
|INTERIM SACRIFICE 1 (c)| 6/10 (60%) 0/0 5/9 (56%) | 6/9 (67%) 0/2 (0%) 2/10 (20%) |
|TERMINAL (d) | 4/4 (100%) 6/6 (100%) 5/6 (83%) | 29/30 (97%) 24/28 (86%) 21/23 (91%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 304 391 | 331 434 367 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.333N P=0.217N P=0.302N | P=0.417N P=0.269N P=0.381N |
|INCIDENTAL TUMOR | P=0.569N P=0.405 P=0.604N | P=0.023N* P=0.057N P=0.012N* |
|LOGISTIC REGRESSION | P=0.571N P=0.261 P=0.558 | P=0.019N* P=0.066N P=0.014N* |
|COCHRAN-ARMITAGE | P=0.570 | P=0.006N** |
|FISHER EXACT | P=0.114 P=0.500 | P=0.135N P=0.007N** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 17/60 (28%) 21/50 (42%) 23/60 (38%) | 33/60 (55%) 27/52 (52%) 24/60 (40%) |
|ADJUSTED (b) | 89.5% 85.9% 79.3% | 70.8% 64.1% 60.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/0 0/9 (0%) | 1/9 (11%) 0/2 (0%) 1/10 (10%) |
|TERMINAL (d) | 3/4 (75%) 4/6 (67%) 3/6 (50%) | 17/30 (57%) 14/28 (50%) 9/23 (39%) |
|FIRST INCIDENCE (DAYS) | 520 304 413 | 456 (I) 494 344 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.354 P=0.529N P=0.379 | P=0.358N P=0.357N P=0.366N |
|INCIDENTAL TUMOR | P=0.208 P=0.340 P=0.219 | P=0.060N P=0.177N P=0.067N |
|LOGISTIC REGRESSION | P=0.210 P=0.215 P=0.189 | P=0.080N P=0.233N P=0.101N |
|COCHRAN-ARMITAGE | P=0.210 | P=0.056N |
|FISHER EXACT | P=0.097 P=0.166 | P=0.446N P=0.072N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05106 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIETHYLPHTHALATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0UL/RAT 100UL 300UL | 0UL/RAT 100UL 300UL |
| | UM RAT LM RAT HM | UF RAT LF RAT HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 52/60 (87%) 49/50 (98%) 55/60 (92%) | 58/60 (97%) 48/52 (92%) 49/60 (82%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 100.0% 100.0% 95.9% |
|INTERIM SACRIFICE 1 (c)| 6/10 (60%) 0/0 5/9 (56%) | 7/9 (78%) 0/2 (0%) 3/10 (30%) |
|TERMINAL (d) | 4/4 (100%) 6/6 (100%) 6/6 (100%) | 30/30 (100%) 28/28 (100%) 21/23 (91%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 304 391 | 331 434 344 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.409N P=0.249N P=0.376N | P=0.445 P=0.436N P=0.508 |
|INCIDENTAL TUMOR | P=0.323 P=0.202 P=0.376 | P=0.009N** P=0.044N* P=0.006N** |
|LOGISTIC REGRESSION | P=0.348 P=0.082 P=0.304 | P=0.014N* P=0.094N P=0.015N* |
|COCHRAN-ARMITAGE | P=0.336 | P=0.004N** |
|FISHER EXACT | P=0.031 * P=0.279 | P=0.274N P=0.008N** |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 456
Female interim sacrifices(days): 456
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).