TDMS Study 05106-01 Pathology Tables
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
Facility: Hazleton, Maryland
Chemical CAS #: 84-66-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 3| 3| 3| 1| 9| 5| 7| 3| 3| 3| 5| 0| 5| 3| 3|
| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 4| 4| 4| 7| 3| 2| 9| 4| 4| 4| 0| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A A + + + + + + A + + +|
Mucosa, Atrophy | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + A A + +|
Mucosa, Atrophy | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X |
Clear Cell Focus | X |
Degeneration, Fatty | 2 1 2 1 |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic, Focal | 2 2 2 1 2|
Inflammation, Focal, Granulomatous | 2 1 2 1 2 |
Mixed Cell Focus | X |
Necrosis | 3 1 |
Bile Duct, Hyperplasia | 2 1 2 2 1 1 3 2 4 2 2 3 2 2 2 2 |
Centrilobular, Degeneration, Fatty | 3 |
Midzonal, Degeneration, Fatty | 2 |
Peripheral, Degeneration, Fatty | |
__________________________________________________________________________|
Mesentery | + |
Fat, Granuloma | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Acinus, Atrophy | 2 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 3 2 2 2 |
Edema | 2 4 2 2 |
Hemorrhage | 3 |
Hyperkeratosis | 3 3 3 2 3 |
Ulcer | 4 3 |
Serosa, Inflammation, Proliferative | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Erosion, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 3| 3| 3| 1| 9| 5| 7| 3| 3| 3| 5| 0| 5| 3| 3|
| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 4| 4| 4| 7| 3| 2| 9| 4| 4| 4| 0| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 2 2 2 2 1 2 1 2 2 1 2 1 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Degeneration, Fatty, Focal | 1 3 3 1 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 1 1 2 2 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + +|
Hypertrophy | 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 1 1 1 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Abscess | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + M + + + + + +|
Ectasia | 2 |
Fibrosis | |
Granuloma | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Endometrium, Atrophy | 2 3 2 2 2 2 3 4 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 3| 3| 3| 1| 9| 5| 7| 3| 3| 3| 5| 0| 5| 3| 3|
| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 4| 4| 4| 7| 3| 2| 9| 4| 4| 4| 0| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematocyst | |
Hematopoietic Cell Proliferation | 4 3 2 2 2 2 2 2 2|
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 2 2 2 3 2 2 2 2 2 3 2 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + M I + + + + + + + + M + + +|
Cyst | X |
Depletion Lymphoid | 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Cystic | 2 3 4 3 3 4 3 |
Hyperplasia | 2 3 3|
Lactation | X X X X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Other, Acanthosis | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 2 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Cerebrum, Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis, Focal | 2 |
Congestion | 2 3 3 3 2 2 2|
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 3| 3| 3| 1| 9| 5| 7| 3| 3| 3| 5| 0| 5| 3| 3|
| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 4| 4| 4| 7| 3| 2| 9| 4| 4| 4| 0| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic | 3 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X |
Inflammation, Chronic | 2|
Inflammation, Suppurative | 4 2 |
Nares, Ulcer | |
Nasolacrimal Duct, Exudate | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + +|
Cataract | 2 3 2 2 3 3 3 3 3 3 2 3 3 3 3|
Hemorrhage | |
Inflammation | |
Cornea, Inflammation | |
Retina, Atrophy | 3 3 2 2 3 3 3 2 2 2 2 3 2 2|
Retrobulbar, Hemorrhage | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
Cyst | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Nephropathy | 1 2 1 2 3 3 3 2 2 3 2 2 1 3 2 1 3 2 2|
Cortex, Mineralization, Focal | 2 2 1 |
Pelvis, Dilatation | 2 |
Pelvis, Epithelium, Hyperplasia | 1 2 2 1 2 2 1 |
Pelvis, Epithelium, Mineralization, | |
Focal | 2 2 2 |
Pelvis, Epithelium, Mineralization | 2 2 2 |
Perirenal Tissue, Inflammation, | |
Suppurative | |
Proximal Convoluted Renal Tubule, | |
Necrosis | |
Proximal Convoluted Renal Tubule, | |
Pigmentation | |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5| 3| 3| 3| 5| 6| 3| 3|
| 4| 4| 4| 9| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 5| 8| 4| 4| 4| 1| 2| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Atrophy | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Atrophy | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | |
Degeneration, Fatty | 3 1 3 2 2 2 2 2 2 |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic, Focal | 2 2 3 2 2 2 2 2 2 2 1 2 2 1 2|
Inflammation, Focal, Granulomatous | |
Mixed Cell Focus | |
Necrosis | |
Bile Duct, Hyperplasia | 2 2 2 1 2 2 2 2 2 2 3 1 2|
Centrilobular, Degeneration, Fatty | 3 3 |
Midzonal, Degeneration, Fatty | 3 |
Peripheral, Degeneration, Fatty | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Granuloma | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Acinus, Atrophy | 2 3 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 3 4 2 3 |
Edema | 2 |
Hemorrhage | 2 |
Hyperkeratosis | 4 2 2 4 3 |
Ulcer | 3 3 |
Serosa, Inflammation, Proliferative | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Erosion, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5| 3| 3| 3| 5| 6| 3| 3|
| 4| 4| 4| 9| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 5| 8| 4| 4| 4| 1| 2| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 3 2 2 2 1 2 2 2 2 2 2 3 2 1 1 1 1 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Degeneration, Fatty, Focal | 2 2 2 2 2 2 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Focal | 2 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + M + + M + + + +|
Hypertrophy | 1 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 |
Hemorrhage | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Abscess | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + M + + + + + + + + M + + +|
Ectasia | 3 3 3 |
Fibrosis | 2 2 |
Granuloma | |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Endometrium, Atrophy | 2 2 2 2 2 4 2 2|
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5| 3| 3| 3| 5| 6| 3| 3|
| 4| 4| 4| 9| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 5| 8| 4| 4| 4| 1| 2| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + M + + + A + + + + + + +|
Hypoplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematocyst | X |
Hematopoietic Cell Proliferation | 2 2 3 1 2 3 2 2 2 1 2 2 2|
Hyperplasia, Lymphoid | 3 |
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thymus | + + + + + M + + M + + + + + + + + + + + + + M + +|
Cyst | X |
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
Hyperplasia | 3 3 3 3 3 3|
Lactation | X X X X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Other, Acanthosis | 2 2 |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 1 1 1 1|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + M + + + A + + + + + + +|
Fibrous Osteodystrophy | X |
Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X|
Cerebrum, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis, Focal | |
Congestion | 2 2 2 3 1 3 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5| 3| 3| 3| 5| 6| 3| 3|
| 4| 4| 4| 9| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 5| 8| 4| 4| 4| 1| 2| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic | 2 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X X |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2|
Inflammation, Suppurative | 3 |
Nares, Ulcer | 3 |
Nasolacrimal Duct, Exudate | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 2 3 3 2 3 3 2 3 3 2 3 3 3 3 3 3 3 3 3 2 3 3 3|
Hemorrhage | 2 2 2 2 |
Inflammation | 3 |
Cornea, Inflammation | 3 2 |
Retina, Atrophy | 2 3 2 2 3 2 2 2 2 3 2 3 2 3 3 3 2 3 2 3 2|
Retrobulbar, Hemorrhage | |
__________________________________________________________________________|
Zymbal's Gland | |
Cyst | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy | 2 2 3 2 2 2 3 2 3 4 2 2 2 2 2 2 3 2 2 2 2 2 3|
Cortex, Mineralization, Focal | |
Pelvis, Dilatation | 2 2 |
Pelvis, Epithelium, Hyperplasia | 2 2 1 2 2 3 1 2 1 2 2 2 1 2|
Pelvis, Epithelium, Mineralization, | |
Focal | |
Pelvis, Epithelium, Mineralization | 2 2 1 1 1 2 1 2 2 1|
Perirenal Tissue, Inflammation, | |
Suppurative | 3 |
Proximal Convoluted Renal Tubule, | |
Necrosis | |
Proximal Convoluted Renal Tubule, | |
Pigmentation | 3 |
Renal Tubule, Mineralization | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + I + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 6| 3| 5| 1| | |
| 5| 5| 5| 5| 3| 0| 5| 4| 6| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Hyperkeratosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + | 55 |
Mucosa, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + | 55 |
Mucosa, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X | 16 |
Clear Cell Focus | X | 2 |
Degeneration, Fatty | 2 | 14 1.9|
Hepatodiaphragmatic Nodule | | 8 |
Inflammation, Chronic, Focal | 2 1 2 2 1 | 25 1.8|
Inflammation, Focal, Granulomatous | | 5 1.6|
Mixed Cell Focus | | 1 |
Necrosis | | 2 2.0|
Bile Duct, Hyperplasia | 2 1 2 2 | 33 2.0|
Centrilobular, Degeneration, Fatty | | 3 3.0|
Midzonal, Degeneration, Fatty | 4 | 3 3.0|
Peripheral, Degeneration, Fatty | 3 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Granuloma | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Fibrosis | | 1 4.0|
Acinus, Atrophy | 1 3 | 10 1.9|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Acanthosis | 3 1 3 4 | 16 2.8|
Edema | 2 | 6 2.3|
Hemorrhage | | 2 2.5|
Hyperkeratosis | 3 1 3 4 | 14 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 6| 3| 5| 1| | |
| 5| 5| 5| 5| 3| 0| 5| 4| 6| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 2 2 3 | 7 2.9|
Serosa, Inflammation, Proliferative | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Mucosa, Erosion, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Cardiomyopathy | 1 3 2 1 2 2 2 | 47 1.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Degeneration, Fatty, Focal | 3 1 3 | 15 2.1|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Focal | 2 2 2 2 | 13 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 58 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + | 54 |
Hypertrophy | 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Angiectasis | 3 3 | 4 3.0|
Hemorrhage | | 1 2.0|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | | 7 1.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | 2 2 2 | 8 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + | 53 |
Ectasia | 2 2 | 6 2.5|
Fibrosis | 2 | 3 2.0|
Granuloma | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 6| 3| 5| 1| | |
| 5| 5| 5| 5| 3| 0| 5| 4| 6| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | | 3 2.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Atrophy | | 1 2.0|
Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Dilatation | | 1 2.0|
Endometrium, Atrophy | 2 2 2 2 2 3 | 23 2.3|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 57 |
Hypoplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematocyst | | 1 |
Hematopoietic Cell Proliferation | 1 2 2 2 2 2 3 3 | 30 2.1|
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation, Hemosiderin | 3 2 2 2 | 24 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 53 |
Cyst | | 2 |
Depletion Lymphoid | | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Hyperplasia, Cystic | | 7 3.1|
Hyperplasia | | 9 2.9|
Lactation | X X X X X X X X X X | 44 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Other, Acanthosis | | 2 2.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 59 |
Acanthosis | | 3 2.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 59 |
Acanthosis | 2 | 8 1.4|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 6| 3| 5| 1| | |
| 5| 5| 5| 5| 3| 0| 5| 4| 6| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 57 |
Fibrous Osteodystrophy | | 1 |
Hyperostosis | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Compression | X X X | 7 |
Cerebrum, Compression | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Atelectasis, Focal | | 1 2.0|
Congestion | 2 2 3 2 3 | 18 2.3|
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | | 2 1.5|
Inflammation, Chronic | 2 | 8 2.1|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 3 |
Inflammation, Chronic | | 10 2.0|
Inflammation, Suppurative | | 3 3.0|
Nares, Ulcer | | 1 3.0|
Nasolacrimal Duct, Exudate | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + | 47 |
Cataract | 3 3 3 3 3 3 3 3 3 | 48 2.8|
Hemorrhage | 3 | 5 2.2|
Inflammation | | 1 3.0|
Cornea, Inflammation | | 2 2.5|
Retina, Atrophy | 2 2 3 3 2 2 | 41 2.4|
Retrobulbar, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 6| 3| 5| 1| | |
| 5| 5| 5| 5| 3| 0| 5| 4| 6| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Hydronephrosis | | 1 2.0|
Nephropathy | 1 3 2 2 2 3 3 1 4 3 | 52 2.3|
Cortex, Mineralization, Focal | | 3 1.7|
Pelvis, Dilatation | | 3 2.0|
Pelvis, Epithelium, Hyperplasia | 2 | 22 1.7|
Pelvis, Epithelium, Mineralization, | | |
Focal | | 3 2.0|
Pelvis, Epithelium, Mineralization | 1 | 14 1.6|
Perirenal Tissue, Inflammation, | | |
Suppurative | | 1 3.0|
Proximal Convoluted Renal Tubule, | | |
Necrosis | 3 | 1 3.0|
Proximal Convoluted Renal Tubule, | | |
Pigmentation | | 1 3.0|
Renal Tubule, Mineralization | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + | 57 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 6| 4| 7| 5| 7| 7| 6| 7| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 5| 1| 3| 6| 3| 3| 4| 3| 3| 3| 7| 5| 4|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 5| 4| 9| 5| 8| 5| 5| 5| 5| 5| 5| 3| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + +|
Hyperkeratosis | 2 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A +|
Edema | 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
Mucosa, Erosion, Focal | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + A A A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A A A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Basophilic Focus | X X X |
Clear Cell Focus | X |
Congestion | |
Degeneration, Fatty | 3 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic, Focal | 2 2 2 2 2|
Inflammation, Focal, Granulomatous | 2 |
Mitotic Alteration | |
Necrosis, Focal | 3 |
Necrosis | 2 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 1 2 1|
Midzonal, Degeneration, Fatty | |
Peripheral, Degeneration, Fatty | 2 |
Periportal, Infiltration Cellular, | |
Mixed Cell | 4 |
Subserosa, Angiectasis | 2 |
__________________________________________________________________________|
Mesentery | + + |
Hemorrhage | |
Fat, Granuloma | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Edema | 3 |
Acinus, Atrophy | 1 3 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Acanthosis | 3 2 2 3 2 |
Edema | 3 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 6| 4| 7| 5| 7| 7| 6| 7| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 5| 1| 3| 6| 3| 3| 4| 3| 3| 3| 7| 5| 4|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 5| 4| 9| 5| 8| 5| 5| 5| 5| 5| 5| 3| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperkeratosis | 3 2 3 3 2 2|
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
Ulcer | |
Mucosa, Erosion, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Polyarteritis | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2 2 1 1 2 2 2 2 2 2 2 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Degeneration, Fatty, Focal | 3 3 3 2 |
Hyperplasia, Focal | 1 1 1 1 2 2 |
Thrombosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
Cytomegaly | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + +|
Hypertrophy | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Pars Distalis, Hyperplasia, Focal | 1 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 |
Follicle, Dilatation | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + M + M + + + + + + M M +|
Cyst | |
Ectasia | |
Fibrosis | |
Hyperplasia | 3 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 6| 4| 7| 5| 7| 7| 6| 7| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 5| 1| 3| 6| 3| 3| 4| 3| 3| 3| 7| 5| 4|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 5| 4| 9| 5| 8| 5| 5| 5| 5| 5| 5| 3| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + +|
Dilatation | |
Endometrium, Atrophy | 2 2 2 2 2 2 2 3 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Hypoplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 3 4 2 2 3 2 2 |
Infarct | |
Necrosis, Focal | 3 |
Pigmentation, Hemosiderin | 2 3 2 2 2 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + M + + + + +|
Congestion | 3 |
Cyst | X |
Depletion Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 |
Hyperplasia | 3|
Lactation | X X X X X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Other, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Compression | X X X |
Hemorrhage, Focal | |
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 6| 4| 7| 5| 7| 7| 6| 7| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 5| 1| 3| 6| 3| 3| 4| 3| 3| 3| 7| 5| 4|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 5| 4| 9| 5| 8| 5| 5| 5| 5| 5| 5| 3| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Congestion | 2 2 3|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic | 1 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic | 2 2 2 2 3 2 |
Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + +|
Cataract | 3 2 3 3 3 3 3 2 3 2 3 3 2|
Inflammation, Chronic | |
Phthisis Bulbi | |
Cornea, Hyperplasia, Focal, Squamous | |
Cornea, Inflammation | 3 2 1 |
Retina, Atrophy | 2 3 2 3 2 3 3 2 2 2 3|
__________________________________________________________________________|
Zymbal's Gland | |
Abscess | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Nephropathy | 3 2 2 2 2 2 4 3 2 3 2 2 1 1|
Collecting Tubule, Casts | X |
Pelvis, Dilatation | 2 |
Pelvis, Epithelium, Hyperplasia | 2 2 2 2 2 3 2 2 1 2 |
Pelvis, Epithelium, Mineralization | 2 1 1 1 1 2 |
Perirenal Tissue, Inflammation, | |
Suppurative | 2 |
Proximal Convoluted Renal Tubule, | |
Necrosis | 4 |
Proximal Convoluted Renal Tubule, | |
Pigmentation | 4 |
Renal Tubule, Mineralization | |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + I + + + + + + +|
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 4| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 7| 9| 1| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 3|
| 5| 5| 5| 7| 3| 4| 3| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Erosion, Focal | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X|
Clear Cell Focus | X X |
Congestion | 3 |
Degeneration, Fatty | 2 2 2 2|
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X X X X |
Inflammation, Chronic, Focal | 2 2 2 2 2 2 1 2 2 3 1 2 2|
Inflammation, Focal, Granulomatous | |
Mitotic Alteration | |
Necrosis, Focal | |
Necrosis | 3 |
Bile Duct, Hyperplasia | 3 1 2 2 2 3 1 2 2 3 2 2 3 2 2 |
Midzonal, Degeneration, Fatty | 2 |
Peripheral, Degeneration, Fatty | 2 3 2 |
Periportal, Infiltration Cellular, | |
Mixed Cell | |
Subserosa, Angiectasis | |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | 2 |
Fat, Granuloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 |
Edema | |
Acinus, Atrophy | 3 2 3 2 4 3 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 3 1 2 3 2|
Edema | 3 2 3 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 4| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 7| 9| 1| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 3|
| 5| 5| 5| 7| 3| 4| 3| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperkeratosis | 2 3 2 3 |
Ulcer | 3 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Mucosa, Erosion, Focal | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Polyarteritis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 1 1 1 3 2 1 2 1 1 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty, Focal | 4 3 2 |
Hyperplasia, Focal | 1 2 2 2 2 |
Thrombosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 2 1 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 4 4 2 3 |
Pars Distalis, Hyperplasia, Focal | 3 3 3 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 1 2 |
Follicle, Dilatation | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M M M + + M M + + + + + + + + + + + + + + +|
Cyst | |
Ectasia | 2 2|
Fibrosis | 2 |
Hyperplasia | |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 4| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 7| 9| 1| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 3|
| 5| 5| 5| 7| 3| 4| 3| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Endometrium, Atrophy | 3 2 2 2 2 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 1 2 1 1 3 2 3|
Infarct | |
Necrosis, Focal | |
Pigmentation, Hemosiderin | 3 2 2 2 3 2 3 2 2 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + M + + + M + + + +|
Congestion | |
Cyst | |
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
Hyperplasia | 2 3 3 4 4 3 |
Lactation | X X X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + M + + + + + + + + + + + + + + + +|
Other, Inflammation, Chronic | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + M + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage, Focal | 2 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 4| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 7| 9| 1| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 3|
| 5| 5| 5| 7| 3| 4| 3| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 2 3 2 2 2 2 2|
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic | 2 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + M + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | 2 2 2 2 2 2 2 |
Inflammation, Suppurative | 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 2 3 2 3 3 3 2 3 3 3 2 3 3 3 3 3 3 3 3 2 2 2 3|
Inflammation, Chronic | 3 |
Phthisis Bulbi | 4 |
Cornea, Hyperplasia, Focal, Squamous | |
Cornea, Inflammation | 3 |
Retina, Atrophy | 2 3 2 3 3 2 2 3 2 2 2 2 2 3 2 2 2 2 2 3 2 3|
__________________________________________________________________________|
Zymbal's Gland | +|
Abscess | 4|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Nephropathy | 1 3 2 3 2 2 3 3 1 2 2 2 2 2 2 2 3 1 3 2 1 3 3 3 4|
Collecting Tubule, Casts | |
Pelvis, Dilatation | 2 |
Pelvis, Epithelium, Hyperplasia | 2 2 4 2 2 2 1 1 1 |
Pelvis, Epithelium, Mineralization | 2 1 1 2 1 1 1 1 1 |
Perirenal Tissue, Inflammation, | |
Suppurative | |
Proximal Convoluted Renal Tubule, | |
Necrosis | |
Proximal Convoluted Renal Tubule, | |
Pigmentation | |
Renal Tubule, Mineralization | 2 2 |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + I + + +|
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 5| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 5| 3| 5| 7| 3| 3| 3| 3| 0| | |
| 3| 1| 5| 5| 4| 5| 5| 5| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 49 |
Hyperkeratosis | | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + A | 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + A | 47 |
Edema | 3 | 2 3.0|
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + A | 47 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A | 49 |
Mucosa, Erosion, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + A | 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 52 |
Angiectasis | 3 | 4 2.5|
Basophilic Focus | X X X | 11 |
Clear Cell Focus | | 3 |
Congestion | | 1 3.0|
Degeneration, Fatty | | 5 2.2|
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | X | 10 |
Inflammation, Chronic, Focal | 1 2 3 2 1 2 | 24 1.9|
Inflammation, Focal, Granulomatous | | 1 2.0|
Mitotic Alteration | 4 | 1 4.0|
Necrosis, Focal | | 1 3.0|
Necrosis | 2 | 3 2.3|
Bile Duct, Hyperplasia | 2 | 28 2.0|
Midzonal, Degeneration, Fatty | | 1 2.0|
Peripheral, Degeneration, Fatty | 3 | 5 2.4|
Periportal, Infiltration Cellular, | | |
Mixed Cell | | 1 4.0|
Subserosa, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Hemorrhage | | 1 2.0|
Fat, Granuloma | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Edema | | 1 3.0|
Acinus, Atrophy | 2 2 3 2 | 16 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 5| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 5| 3| 5| 7| 3| 3| 3| 3| 0| | |
| 3| 1| 5| 5| 4| 5| 5| 5| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Acanthosis | 2 | 13 2.2|
Edema | | 4 2.8|
Hyperkeratosis | 2 | 11 2.5|
Ulcer | | 4 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Ulcer | 3 | 1 3.0|
Mucosa, Erosion, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Polyarteritis | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 51 |
Cardiomyopathy | 1 1 2 2 1 1 | 34 1.6|
Atrium, Thrombosis | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Degeneration, Fatty, Focal | 2 | 8 2.8|
Hyperplasia, Focal | 2 | 12 1.6|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Hyperplasia, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Cytomegaly | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 50 |
Hypertrophy | 2 | 4 1.8|
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + | 50 |
Angiectasis | | 6 3.3|
Pars Distalis, Hyperplasia, Focal | | 7 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia | 1 | 6 1.3|
Follicle, Dilatation | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 5| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 5| 3| 5| 7| 3| 3| 3| 3| 0| | |
| 3| 1| 5| 5| 4| 5| 5| 5| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + + + | 39 |
Cyst | X | 1 |
Ectasia | | 2 2.0|
Fibrosis | | 1 2.0|
Hyperplasia | | 1 3.0|
Inflammation, Chronic | | 2 3.0|
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 50 |
Atrophy | | 1 2.0|
Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Dilatation | 2 2 | 2 2.0|
Endometrium, Atrophy | 2 2 2 2 | 24 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + M + + + + + + | 49 |
Hypoplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 52 |
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | 3 2 4 2 2 2 | 26 2.2|
Infarct | 3 | 1 3.0|
Necrosis, Focal | | 1 3.0|
Pigmentation, Hemosiderin | 3 2 2 | 21 2.2|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + M + | 43 |
Congestion | | 1 3.0|
Cyst | | 1 |
Depletion Lymphoid | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + | 49 |
Hyperplasia, Cystic | | 1 3.0|
Hyperplasia | 3 2 | 9 3.0|
Lactation | X X X X X X X X | 42 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 5| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 5| 3| 5| 7| 3| 3| 3| 3| 0| | |
| 3| 1| 5| 5| 4| 5| 5| 5| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 49 |
Other, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 49 |
Acanthosis | 1 1 1 2 1 | 18 1.1|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + M + + + + + + | 49 |
Osteopetrosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Compression | X | 5 |
Hemorrhage, Focal | | 1 2.0|
Hydrocephalus | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Congestion | 3 3 2 | 15 2.3|
Hemorrhage | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Chronic | 1 | 7 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Foreign Body | | 1 2.0|
Inflammation, Chronic | 2 2 2 2 2 | 18 2.1|
Inflammation, Suppurative | | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 | 4 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + + + + + + | 44 |
Cataract | 3 3 3 2 3 3 3 3 | 44 2.7|
Inflammation, Chronic | | 1 3.0|
Phthisis Bulbi | | 1 4.0|
Cornea, Hyperplasia, Focal, Squamous | 3 | 1 3.0|
Cornea, Inflammation | | 4 2.3|
Retina, Atrophy | 2 3 3 3 3 | 38 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 5| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 5| 3| 5| 7| 3| 3| 3| 3| 0| | |
| 3| 1| 5| 5| 4| 5| 5| 5| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 51 |
Inflammation, Suppurative | | 1 3.0|
Nephropathy | 1 3 2 2 2 2 2 | 46 2.2|
Collecting Tubule, Casts | | 1 |
Pelvis, Dilatation | 2 | 3 2.0|
Pelvis, Epithelium, Hyperplasia | 2 2 2 2 | 23 2.0|
Pelvis, Epithelium, Mineralization | 2 | 16 1.3|
Perirenal Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
Proximal Convoluted Renal Tubule, | | |
Necrosis | | 1 4.0|
Proximal Convoluted Renal Tubule, | | |
Pigmentation | 3 | 2 3.5|
Renal Tubule, Mineralization | | 2 2.0|
Renal Tubule, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | M + + + + + + + + + | 47 |
Lumen, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 5| 5| 5| 5| 7| 6| 7| 5| 3| 7| 6| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 6| 9| 9| 8| 3| 8| 3| 8| 6| 3| 5| 4| 2|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 9| 5| 1| 4| 4| 9| 4| 5| 7| 4| 7| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + A + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
Edema | 3 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + A + + + A + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X |
Clear Cell Focus | X |
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | 1|
Hepatodiaphragmatic Nodule | X |
Infiltration Cellular, Focal, | |
Histiocyte | 2 |
Inflammation, Chronic, Focal | 2 2 2 1 1 3 3 2 1 1 |
Inflammation, Focal, Granulomatous | 2 1 |
Mixed Cell Focus | X |
Necrosis | |
Pigmentation, Focal | 2 |
Bile Duct, Hyperplasia | 2 2 2 1 2 2 1 2 1 3 2 1 2 2 1 2 |
Hepatocyte, Hyperplasia | 4 |
Peripheral, Degeneration, Fatty | |
__________________________________________________________________________|
Mesentery | |
Polyarteritis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 |
Fibrosis, Focal | |
Inflammation, Focal | |
Acinus, Atrophy | 2 2 1 2 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 3 |
Cyst Epithelial Inclusion | |
Edema | 3 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 5| 5| 5| 5| 7| 6| 7| 5| 3| 7| 6| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 6| 9| 9| 8| 3| 8| 3| 8| 6| 3| 5| 4| 2|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 9| 5| 1| 4| 4| 9| 4| 5| 7| 4| 7| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperkeratosis | 2 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Mucosa, Erosion, Focal | |
__________________________________________________________________________|
Tooth | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4|
Cardiomyopathy | 1 1 2 1 2 1 1 1 1 2 1 1 2 2 1 2|
Atrium, Thrombosis | |
Myocardium, Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty, Focal | 1 2 |
Hyperplasia, Focal | 2 1 1 |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hypertrophy | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia, Focal | 1 3 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
Follicle, Dilatation | 1 |
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | +|
Abscess | 4|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + M M M + + + + + + + M M M|
Ectasia | 4 |
Fibrosis | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 5| 5| 5| 5| 7| 6| 7| 5| 3| 7| 6| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 6| 9| 9| 8| 3| 8| 3| 8| 6| 3| 5| 4| 2|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 9| 5| 1| 4| 4| 9| 4| 5| 7| 4| 7| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation | 2|
Endometrium, Atrophy | 3 2 3 3 3 2|
__________________________________________________________________________|
Vagina | |
Exudate | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hypoplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 4 1 2 3 2 4|
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 3 |
Capsule, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + M + I +|
Cyst | |
Depletion Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 2 3 3 |
Hyperplasia | 3 3 |
Lactation | X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Other, Acanthosis | 1 |
Other, Hyperkeratosis | 1 |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 2 1 1 1 1 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 5| 5| 5| 5| 7| 6| 7| 5| 3| 7| 6| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 6| 9| 9| 8| 3| 8| 3| 8| 6| 3| 5| 4| 2|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 9| 5| 1| 4| 4| 9| 4| 5| 7| 4| 7| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | 2 |
Congestion | 3 2 2 2 2 1 2|
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic | 2 2 3 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 |
Foreign Body | 3 2 |
Fungus | |
Inflammation, Chronic | 2 2 2 |
Inflammation, Suppurative | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + |
Cataract | 3 3 3 3 3 3 3 3 3 2 3 |
Hemorrhage | |
Cornea, Inflammation | |
Retina, Atrophy | 3 3 2 3 3 3 3 3 2 3 |
__________________________________________________________________________|
Zymbal's Gland | |
Cyst | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Nephropathy | 1 1 2 1 1 1 1 2 2 2 2 2 2 2 3 2 2 1 2 2 1 |
Cortex, Mineralization, Focal | 2 2 |
Medulla, Necrosis | |
Pelvis, Epithelium, Hyperplasia | 1 1 1 2 1 2 1 2 1 2 2 |
Pelvis, Epithelium, Mineralization, | |
Focal | 1 1 2 1 |
Pelvis, Epithelium, Mineralization | 2 |
Proximal Convoluted Renal Tubule, | |
Necrosis | 4 |
Renal Tubule, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 5| 5| 5| 5| 7| 6| 7| 5| 3| 7| 6| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 6| 9| 9| 8| 3| 8| 3| 8| 6| 3| 5| 4| 2|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 9| 5| 1| 4| 4| 9| 4| 5| 7| 4| 7| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 3| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 4| 3| 3| 8|
| 8| 5| 9| 5| 5| 9| 8| 5| 6| 5| 5| 4| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A A + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A A + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X |
Clear Cell Focus | X X |
Degeneration, Fatty | 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Infiltration Cellular, Focal, | |
Histiocyte | |
Inflammation, Chronic, Focal | 2 2 1 2 3 2 1 2 2 2 2 2 2 |
Inflammation, Focal, Granulomatous | |
Mixed Cell Focus | X |
Necrosis | 1 |
Pigmentation, Focal | |
Bile Duct, Hyperplasia | 2 2 2 2 3 2 2 2 2 2 2 2 |
Hepatocyte, Hyperplasia | |
Peripheral, Degeneration, Fatty | 2 2 |
__________________________________________________________________________|
Mesentery | |
Polyarteritis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 |
Fibrosis, Focal | |
Inflammation, Focal | |
Acinus, Atrophy | 1 1 1 1 3 3 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 2 2 3 3 2|
Cyst Epithelial Inclusion | X |
Edema | 2 2 2 4 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 3| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 4| 3| 3| 8|
| 8| 5| 9| 5| 5| 9| 8| 5| 6| 5| 5| 4| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperkeratosis | 3 2 2 2 3 2|
Ulcer | 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Mucosa, Erosion, Focal | 3 3 |
__________________________________________________________________________|
Tooth | + |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cardiomyopathy | 1 3 2 2 2 1 2 2 1 2 2 2 2 2 1 3 2 2 2|
Atrium, Thrombosis | X X |
Myocardium, Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty, Focal | 2 2 1 1 2 2 |
Hyperplasia, Focal | 2 1 2 1|
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + M + + +|
Hypertrophy | 3 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 3 2 2 2 2|
Follicle, Dilatation | 2 3 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Abscess | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M M + + + + + + + + + + + + + + + + + M|
Ectasia | 3 |
Fibrosis | 2 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 3| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 4| 3| 3| 8|
| 8| 5| 9| 5| 5| 9| 8| 5| 6| 5| 5| 4| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Inflammation | |
Endometrium, Atrophy | 2 2 2 2 2 2 |
__________________________________________________________________________|
Vagina | + |
Exudate | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 4 |
Hematopoietic Cell Proliferation | 1 2 3 2 2 2 2 2 2 2 3|
Pigmentation, Hemosiderin | 3 2 3 2 2 2 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +|
Cyst | X |
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
Hyperplasia | 3 3 4 2 3 2 3 |
Lactation | X X X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Other, Acanthosis | |
Other, Hyperkeratosis | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X |
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 3| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 4| 3| 3| 8|
| 8| 5| 9| 5| 5| 9| 8| 5| 6| 5| 5| 4| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | |
Congestion | 2 2 2 3 3 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Foreign Body | 2 2 |
Fungus | X |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Suppurative | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + I + + + + + + + + + + + + + + +|
Cataract | 3 3 3 3 3 3 2 2 3 2 3 3 3 3 3 3 3 3 3 3 3 3|
Hemorrhage | 3 |
Cornea, Inflammation | 2 3 2 |
Retina, Atrophy | 2 3 2 2 2 2 2 2 3 2 3 2 2 2 2 2 3 3|
__________________________________________________________________________|
Zymbal's Gland | + |
Cyst | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Nephropathy | 2 2 1 2 3 2 2 2 2 3 2 2 3 2 2 4 2 4 2 2 1 1 2 3 4|
Cortex, Mineralization, Focal | |
Medulla, Necrosis | 2 |
Pelvis, Epithelium, Hyperplasia | 1 2 2 2 1 2 1 2 1 2 2|
Pelvis, Epithelium, Mineralization, | |
Focal | |
Pelvis, Epithelium, Mineralization | 1 2 1 2 1 2 1 1 2 1 1|
Proximal Convoluted Renal Tubule, | |
Necrosis | 3 |
Renal Tubule, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 3| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 4| 3| 3| 8|
| 8| 5| 9| 5| 5| 9| 8| 5| 6| 5| 5| 4| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 4| 6| 7| 5| 7| 7| | |
DAY ON TEST | 8| 8| 3| 4| 3| 1| 3| 4| 3| 2| | |
| 8| 7| 4| 1| 0| 1| 5| 9| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 56 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
Edema | | 2 3.0|
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Basophilic Focus | X | 6 |
Clear Cell Focus | | 3 |
Degeneration, Fatty | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | | 3 |
Infiltration Cellular, Focal, | | |
Histiocyte | | 1 2.0|
Inflammation, Chronic, Focal | 2 2 1 2 | 27 1.9|
Inflammation, Focal, Granulomatous | | 2 1.5|
Mixed Cell Focus | | 2 |
Necrosis | 2 | 2 1.5|
Pigmentation, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 2 1 2 2 2 2 3 | 35 1.9|
Hepatocyte, Hyperplasia | | 1 4.0|
Peripheral, Degeneration, Fatty | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Polyarteritis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Cytoplasmic Alteration, Focal | | 2 2.0|
Fibrosis, Focal | 3 | 1 3.0|
Inflammation, Focal | 3 | 1 3.0|
Acinus, Atrophy | 2 1 3 2 | 16 1.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 4| 6| 7| 5| 7| 7| | |
DAY ON TEST | 8| 8| 3| 4| 3| 1| 3| 4| 3| 2| | |
| 8| 7| 4| 1| 0| 1| 5| 9| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Acanthosis | 4 | 11 2.5|
Cyst Epithelial Inclusion | | 1 |
Edema | 2 | 6 2.5|
Hemorrhage | | 1 2.0|
Hyperkeratosis | 2 | 8 2.3|
Ulcer | 4 | 4 3.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Ulcer | 3 3 | 2 3.0|
Mucosa, Erosion, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Abscess | | 1 4.0|
Cardiomyopathy | 2 1 1 | 38 1.6|
Atrium, Thrombosis | X | 3 |
Myocardium, Mineralization, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Degeneration, Fatty, Focal | 2 | 9 1.7|
Hyperplasia, Focal | 2 | 8 1.5|
Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia, Focal | 3 3 | 5 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
Hypertrophy | | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + | 58 |
Angiectasis | 4 | 3 2.7|
Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia, Focal | 3 2 3 | 9 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | | 6 2.3|
Follicle, Dilatation | | 4 2.0|
Follicular Cell, Hyperplasia | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 4| 6| 7| 5| 7| 7| | |
DAY ON TEST | 8| 8| 3| 4| 3| 1| 3| 4| 3| 2| | |
| 8| 7| 4| 1| 0| 1| 5| 9| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + | 50 |
Ectasia | 3 2 3 | 5 3.0|
Fibrosis | 2 2 | 3 2.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Atrophy | | 2 2.5|
Cyst | | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Dilatation | | 1 2.0|
Inflammation | | 1 2.0|
Endometrium, Atrophy | 2 2 2 | 15 2.3|
__________________________________________________________________________|____________|
Vagina | | 1 |
Exudate | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Hypoplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 2 3.5|
Hematopoietic Cell Proliferation | 2 2 3 2 | 22 2.3|
Pigmentation, Hemosiderin | 3 3 3 3 2 | 27 2.2|
Capsule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M M + + + + M + + M | 52 |
Cyst | | 1 |
Depletion Lymphoid | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia, Cystic | | 5 2.2|
Hyperplasia | | 9 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 4| 6| 7| 5| 7| 7| | |
DAY ON TEST | 8| 8| 3| 4| 3| 1| 3| 4| 3| 2| | |
| 8| 7| 4| 1| 0| 1| 5| 9| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Lactation | X X X X X X X X X X | 43 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Other, Acanthosis | | 1 1.0|
Other, Hyperkeratosis | | 1 1.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 60 |
Acanthosis | 1 1 2 1 1 1 1 | 23 1.1|
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | | 1 |
Hyperostosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X | 9 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Atelectasis | | 1 2.0|
Congestion | 1 3 | 14 2.1|
Infiltration Cellular, Histiocyte | | 2 1.5|
Inflammation, Chronic | | 4 2.3|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | | 1 2.0|
Foreign Body | | 4 2.3|
Fungus | | 1 |
Inflammation, Chronic | 2 2 2 | 16 2.0|
Inflammation, Suppurative | | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Glands, Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + | 39 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 4| 6| 7| 5| 7| 7| | |
DAY ON TEST | 8| 8| 3| 4| 3| 1| 3| 4| 3| 2| | |
| 8| 7| 4| 1| 0| 1| 5| 9| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cataract | 3 3 3 3 3 3 | 39 2.9|
Hemorrhage | 2 | 2 2.5|
Cornea, Inflammation | | 3 2.3|
Retina, Atrophy | 3 3 2 3 | 32 2.5|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 2 | 2 1.5|
Nephropathy | 2 2 2 2 1 1 2 1 3 | 55 2.0|
Cortex, Mineralization, Focal | | 2 2.0|
Medulla, Necrosis | | 1 2.0|
Pelvis, Epithelium, Hyperplasia | 2 1 2 1 | 26 1.5|
Pelvis, Epithelium, Mineralization, | | |
Focal | | 4 1.3|
Pelvis, Epithelium, Mineralization | 1 | 13 1.4|
Proximal Convoluted Renal Tubule, | | |
Necrosis | | 2 3.5|
Renal Tubule, Mineralization | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | M + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 5| 5| 7| 4| 5| 7| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 7| 1| 4| 7| 0| 0| 9| 7| 3| 7| 6| 3| 8| 9|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 9| 4| 3| 9| 2| 7| 1| 4| 8| 8| 4| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Necrosis | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + A + + + + + A +|
Congestion | |
Edema | 3 |
Serosa, Necrosis, Focal | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + M + +|
Edema | |
Parasite Metazoan | X X |
Muscularis, Degeneration, Focal | |
Serosa, Necrosis, Focal | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Mucosa, Erosion, Focal | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Hemorrhage, Focal | 3 |
Mucosa, Necrosis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + A + + + + + + +|
Intussusception | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Degeneration, Cystic, Focal | 3 |
Degeneration, Fatty, Focal | 2 |
Degeneration, Fatty | 2 2 2 1 1 3 2|
Eosinophilic Focus | X |
Focal Cellular Change | 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic, Focal | 2 1 |
Inflammation, Focal, Granulomatous | 2 2 1 2 2 2 2 2 |
Necrosis | |
Bile Duct, Hyperplasia | 2 2 2 3 2 3 2 3 2 3 2 2 2 2 3 2 2 2 3 2 2 2 2|
Centrilobular, Degeneration, Fatty | |
Hepatocyte, Atrophy | |
Hepatocyte, Hyperplasia, Focal | 2 |
Midzonal, Degeneration, Fatty | 3 |
Peripheral, Degeneration, Fatty | 2 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Granuloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 5| 5| 7| 4| 5| 7| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 7| 1| 4| 7| 0| 0| 9| 7| 3| 7| 6| 3| 8| 9|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 9| 4| 3| 9| 2| 7| 1| 4| 8| 8| 4| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Accessory Spleen | X |
Cytoplasmic Alteration, Focal | |
Fibrosis | |
Acinus, Atrophy | 1 2 1 2 2 3 3 3 2 |
Acinus, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Necrosis, Focal | 3|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 3 1 3 3 3 3 4 2|
Edema | 3 2 2 |
Hyperkeratosis | 4 3 2 3 2 2 3 4 2|
Ulcer | 4 2 3|
Muscularis, Necrosis | |
Serosa, Necrosis, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Foreign Body | 1 |
Mucosa, Degeneration | 2 3 |
Mucosa, Erosion, Focal | 2 |
Muscularis, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + +|
Degeneration | 3 3 3|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cardiomyopathy | 2 3 2 2 2 2 2 3 1 2 3 2 2 4 2 2 1 2 2 3|
Atrium, Dilatation | 3 |
Atrium, Thrombosis | |
Myocardium, Necrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + M + + + + + + + + + + + + +|
Angiectasis | |
Degeneration, Fatty, Focal | 2 2 4 2 2|
Degeneration | 3 2 2 |
Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 3 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 5| 5| 7| 4| 5| 7| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 7| 1| 4| 7| 0| 0| 9| 7| 3| 7| 6| 3| 8| 9|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 9| 4| 3| 9| 2| 7| 1| 4| 8| 8| 4| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Focal | |
Hypertrophy | 3 1 3 4 2 2 2 4|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + I + + + + +|
Pigmentation, Hemosiderin | 4 |
Pigmentation | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation | 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 3 2 4 2 4 4 3 1 2 4 4|
Fibrosis | 2 4 2 2 2 3|
__________________________________________________________________________|
Penis | + + |
Inflammation, Acute | 3 |
Thrombosis | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + M M + M + + + M M + + M + M +|
Abscess | 4 |
Ectasia | 3 |
Fibrosis | 2 3 2 2 2|
Duct, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Focal | 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 3 3 4 3 2 3 4 3 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + M + + +|
Atrophy | 3 3 3 3 2|
Depletion Cellular | 3 3 3 |
Hyperplasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | |
Polyarteritis | |
Interstitial Cell, Hyperplasia | 1 |
Seminiferous Tubule, Atrophy | 4 3 3 3 4 3 3|
Seminiferous Tubule, Degeneration | 3 3 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 5| 5| 7| 4| 5| 7| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 7| 1| 4| 7| 0| 0| 9| 7| 3| 7| 6| 3| 8| 9|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 9| 4| 3| 9| 2| 7| 1| 4| 8| 8| 4| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + A + + + + + + + + + + + + +|
Hypoplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Mediastinal, Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + M M +|
Hemorrhage | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Depletion Lymphoid | |
Fibrosis | 3 3 |
Hematopoietic Cell Proliferation | 2 2 |
Pigmentation, Hemosiderin | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + M + M + + + + + I +|
Depletion Lymphoid | 3 3 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + M +|
Abscess | |
Hyperplasia | |
Lactation | X X X X X X X X X X X X X|
Duct, Ectasia | |
Duct, Pigmentation | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abdominal, Inflammation, Suppurative | |
Other, Cyst Epithelial Inclusion | |
Other, Inflammation, Suppurative | |
Prepuce, Hyperkeratosis | 2 |
Prepuce, Inflammation | 2 |
Sebaceous Gland, Site of | |
Application-Mass, Hyperplasia | |
Site of Application-Mass, Fibrosis, | |
Focal | |
Site of Application-Mass, | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 5| 5| 7| 4| 5| 7| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 7| 1| 4| 7| 0| 0| 9| 7| 3| 7| 6| 3| 8| 9|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 9| 4| 3| 9| 2| 7| 1| 4| 8| 8| 4| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Proliferation Connective Tissue | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + M + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X X X X|
Hypoplasia | |
__________________________________________________________________________|
Skeletal Muscle | |
Degeneration, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hemorrhage | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | |
Congestion | 2 3 3 3 2 3 |
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 3|
Inflammation, Chronic | 3 3 2 3 3 1 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | 4 |
Infiltration Cellular, Diffuse, | |
Lymphocyte | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 1 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Hyperkeratosis | 1 |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + +|
Cataract | 2 3 2 3 3 3 3 3 3 3 3 2 3 3 2 3|
Hemorrhage | 2 2 |
Synechia | 4 |
Anterior Chamber, Hemorrhage | 2 |
Cornea, Inflammation | |
Retina, Atrophy | 3 3 3 3 3 2 2 3 2 3 3 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 5| 5| 7| 4| 5| 7| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 7| 1| 4| 7| 0| 0| 9| 7| 3| 7| 6| 3| 8| 9|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 9| 4| 3| 9| 2| 7| 1| 4| 8| 8| 4| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Nephropathy | 3 2 3 3 2 3 3 2 3 3 3 3 4 4 2 4 4 4 3 3 3 3 4 3 4|
Pelvis, Dilatation | |
Pelvis, Epithelium, Hyperplasia | 2 2 2 2 2 3 2 2 2|
Pelvis, Epithelium, Inflammation | |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + M +|
Hemorrhage | |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Necrosis | |
Mucosa, Hyperplasia | 3 3 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 2| 6| 5| 5| 5| 6| 6| 6| 5| 7| 6| 6| 3| 6| 6| 6| 6| 5| 6| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 6| 0| 8| 8| 2| 9| 2| 8| 0| 3| 8| 2| 9| 5| 5| 2| 3| 6| 6| 7| 3| 9| 9| 4| 3|
| 4| 0| 2| 7| 7| 1| 6| 7| 2| 0| 0| 9| 9| 2| 1| 9| 6| 8| 8| 4| 4| 8| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 3 3|
Necrosis | 4 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + A A + + + + A + + + A + + + + + + + + +|
Congestion | |
Edema | |
Serosa, Necrosis, Focal | |
__________________________________________________________________________|
Intestine Large, Colon | A + + A + A A + + + + A + + + A + + + + + + + + +|
Edema | |
Parasite Metazoan | X |
Muscularis, Degeneration, Focal | 2 |
Serosa, Necrosis, Focal | |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Erosion, Focal | 3 2 3 |
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + A + + + + + + + + + A + + + + + + + + +|
Hemorrhage, Focal | |
Mucosa, Necrosis | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + A + + + + + A + + + A + + + + + + + + +|
Intussusception | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X X |
Degeneration, Cystic, Focal | |
Degeneration, Fatty, Focal | |
Degeneration, Fatty | 1 2 2 1 1 1 2 1 1|
Eosinophilic Focus | X |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic, Focal | 3 2 1 1 1 |
Inflammation, Focal, Granulomatous | |
Necrosis | 1 |
Bile Duct, Hyperplasia | 2 2 3 2 2 2 2 2 2 2 2 2 2 3 2 1 2 2 2 2 2|
Centrilobular, Degeneration, Fatty | 3 |
Hepatocyte, Atrophy | 2 |
Hepatocyte, Hyperplasia, Focal | |
Midzonal, Degeneration, Fatty | 2 |
Peripheral, Degeneration, Fatty | 3 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Granuloma | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 2| 6| 5| 5| 5| 6| 6| 6| 5| 7| 6| 6| 3| 6| 6| 6| 6| 5| 6| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 6| 0| 8| 8| 2| 9| 2| 8| 0| 3| 8| 2| 9| 5| 5| 2| 3| 6| 6| 7| 3| 9| 9| 4| 3|
| 4| 0| 2| 7| 7| 1| 6| 7| 2| 0| 0| 9| 9| 2| 1| 9| 6| 8| 8| 4| 4| 8| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Accessory Spleen | |
Cytoplasmic Alteration, Focal | |
Fibrosis | 4 |
Acinus, Atrophy | 2 1 3 1 |
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Necrosis, Focal | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 1 3 3 4 3 2 4 3 4 3|
Edema | 2 3 2 2 2 2 2 3|
Hyperkeratosis | 2 2 3 2 4 3 2 4 3 4 3|
Ulcer | 3 3 4 3 2 3 4|
Muscularis, Necrosis | 3 |
Serosa, Necrosis, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Foreign Body | |
Mucosa, Degeneration | 3 3 3 3 2 2 2 |
Mucosa, Erosion, Focal | |
Muscularis, Necrosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + |
Degeneration | 3 2 2 2 3 2 3 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Cardiomyopathy | 2 4 1 3 2 4 3 1 2 3 4 4 2 3 3 2 2 2 2 1 2 2 2|
Atrium, Dilatation | |
Atrium, Thrombosis | X X X X X |
Myocardium, Necrosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Degeneration, Fatty, Focal | 1 2 2 3 2 3 2 2 1 3 2 1|
Degeneration | 2 3 2 |
Hyperplasia, Focal | 1 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 3 2 2 2 3 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 2| 6| 5| 5| 5| 6| 6| 6| 5| 7| 6| 6| 3| 6| 6| 6| 6| 5| 6| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 6| 0| 8| 8| 2| 9| 2| 8| 0| 3| 8| 2| 9| 5| 5| 2| 3| 6| 6| 7| 3| 9| 9| 4| 3|
| 4| 0| 2| 7| 7| 1| 6| 7| 2| 0| 0| 9| 9| 2| 1| 9| 6| 8| 8| 4| 4| 8| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Focal | |
Hypertrophy | 4 2 3 1 3 3 3 3 3 3 3 3 1 3 3 3 2 4 2|
__________________________________________________________________________|
Pituitary Gland | M + I + + + + + + + + M + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | |
Pigmentation | 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Thyroid Gland | A + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation | |
__________________________________________________________________________|
Epididymis | + I + + + + A + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 2 2 3 3 3 4 3 2 3 2 1 3 2 2 3 3 4 3 3|
Fibrosis | 3 3 3 3 2 3 2 2 3 3 2 |
__________________________________________________________________________|
Penis | + + + |
Inflammation, Acute | 2 |
Thrombosis | |
__________________________________________________________________________|
Preputial Gland | + + M + M + + + M + + + + + + + + M + + + + + + M|
Abscess | 3 |
Ectasia | 2 2 |
Fibrosis | 2 2 2 2 2 2 2 3 2 2 2 3 2 3 |
Duct, Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 3 3 4 3 4 3 4 3 3 4 4 3 2 3 3 3 3|
__________________________________________________________________________|
Seminal Vesicle | A + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 2 2 3 3 |
Depletion Cellular | 3 4 4 4 3 3 3 3 3 3 3 2|
Hyperplasia | 3 |
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | 2 |
Polyarteritis | 3 3 3 |
Interstitial Cell, Hyperplasia | 1 1 1 |
Seminiferous Tubule, Atrophy | 2 3 3 3 1 4 2 2 2 4 2|
Seminiferous Tubule, Degeneration | 4 2 3 3 2 2 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 2| 6| 5| 5| 5| 6| 6| 6| 5| 7| 6| 6| 3| 6| 6| 6| 6| 5| 6| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 6| 0| 8| 8| 2| 9| 2| 8| 0| 3| 8| 2| 9| 5| 5| 2| 3| 6| 6| 7| 3| 9| 9| 4| 3|
| 4| 0| 2| 7| 7| 1| 6| 7| 2| 0| 0| 9| 9| 2| 1| 9| 6| 8| 8| 4| 4| 8| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mediastinal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | A + + + + + + + + + + + + + + + + I + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 4 |
Depletion Lymphoid | 3 |
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | 3 3 2 |
Pigmentation, Hemosiderin | 4 2 2 2 2 2 3 1 2 2 2|
__________________________________________________________________________|
Thymus | + + + M + M + + + M + M M + M + + M + M + + M + +|
Depletion Lymphoid | 2 3 3|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M M + + + + + M + + +|
Abscess | |
Hyperplasia | |
Lactation | X X X X X X X X X X X X X X X X X X|
Duct, Ectasia | 3 |
Duct, Pigmentation | |
__________________________________________________________________________|
Skin | + + + + + + M + + + + + + + + + + + + + + + + + +|
Abdominal, Inflammation, Suppurative | 1 |
Other, Cyst Epithelial Inclusion | X |
Other, Inflammation, Suppurative | 3|
Prepuce, Hyperkeratosis | |
Prepuce, Inflammation | |
Sebaceous Gland, Site of | |
Application-Mass, Hyperplasia | 2 |
Site of Application-Mass, Fibrosis, | |
Focal | 2 |
Site of Application-Mass, | |
Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Cyst Epithelial Inclusion | X X|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 2| 6| 5| 5| 5| 6| 6| 6| 5| 7| 6| 6| 3| 6| 6| 6| 6| 5| 6| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 6| 0| 8| 8| 2| 9| 2| 8| 0| 3| 8| 2| 9| 5| 5| 2| 3| 6| 6| 7| 3| 9| 9| 4| 3|
| 4| 0| 2| 7| 7| 1| 6| 7| 2| 0| 0| 9| 9| 2| 1| 9| 6| 8| 8| 4| 4| 8| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Proliferation Connective Tissue | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X X X X X X X X X X X X X X |
Hypoplasia | 2|
__________________________________________________________________________|
Skeletal Muscle | + |
Degeneration, Focal | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | 2 2 |
Congestion | 3 3 2 2 2 2 2 2|
Hemorrhage | |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic | 4 1 3 4 3 2 3 2 2 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | X X X |
Infiltration Cellular, Diffuse, | |
Lymphocyte | |
Inflammation, Chronic | 2 3 2 2 |
Inflammation, Suppurative | 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
__________________________________________________________________________|
Trachea | A + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Hyperkeratosis | |
__________________________________________________________________________|
Eye | + + + M + + + + + + + + + + + + + + + + +|
Cataract | 2 3 3 3 2 3 3 4 2 3 3 3 3 3 3 3 3 3 3|
Hemorrhage | 3 |
Synechia | |
Anterior Chamber, Hemorrhage | |
Cornea, Inflammation | 3 2 2 3 |
Retina, Atrophy | 2 2 2 2 2 3 2 3 2 3 3 2 3 2 3 2 2 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 2| 6| 5| 5| 5| 6| 6| 6| 5| 7| 6| 6| 3| 6| 6| 6| 6| 5| 6| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 6| 0| 8| 8| 2| 9| 2| 8| 0| 3| 8| 2| 9| 5| 5| 2| 3| 6| 6| 7| 3| 9| 9| 4| 3|
| 4| 0| 2| 7| 7| 1| 6| 7| 2| 0| 0| 9| 9| 2| 1| 9| 6| 8| 8| 4| 4| 8| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 UL/RAT | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Nephropathy | 1 4 2 4 2 4 4 4 4 4 4 4 2 3 4 2 4 4 4 4 3 4 4 3 3|
Pelvis, Dilatation | 2 |
Pelvis, Epithelium, Hyperplasia | 4 2 3 3 2 2 2 2 2 2 2 3 2 2 |
Pelvis, Epithelium, Inflammation | 2 |
Renal Tubule, Mineralization | 3 |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 3 |
Necrosis | 3 |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 7| 6| 5| 5| 6| 5| 6| | |
DAY ON TEST | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8| | |
| 0| 8| 2| 5| 6| 4| 4| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Hyperkeratosis | | 4 2.5|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + | 50 |
Congestion | 4 | 1 4.0|
Edema | | 1 3.0|
Serosa, Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + M + + | 51 |
Edema | 4 | 1 4.0|
Parasite Metazoan | | 3 |
Muscularis, Degeneration, Focal | | 1 2.0|
Serosa, Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + + + + + + + + | 57 |
Mucosa, Erosion, Focal | | 3 2.7|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + | 54 |
Hemorrhage, Focal | | 1 3.0|
Mucosa, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + | 52 |
Intussusception | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 1 |
Clear Cell Focus | X | 4 |
Degeneration, Cystic, Focal | 2 | 2 2.5|
Degeneration, Fatty, Focal | | 1 2.0|
Degeneration, Fatty | 2 2 1 | 19 1.6|
Eosinophilic Focus | | 2 |
Focal Cellular Change | | 1 1.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | | 2 |
Inflammation, Chronic, Focal | 2 2 | 9 1.7|
Inflammation, Focal, Granulomatous | | 8 1.9|
Necrosis | | 1 1.0|
Bile Duct, Hyperplasia | 3 2 2 2 3 2 2 2 3 | 53 2.2|
Centrilobular, Degeneration, Fatty | | 1 3.0|
Hepatocyte, Atrophy | | 1 2.0|
Hepatocyte, Hyperplasia, Focal | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 7| 6| 5| 5| 6| 5| 6| | |
DAY ON TEST | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8| | |
| 0| 8| 2| 5| 6| 4| 4| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Midzonal, Degeneration, Fatty | | 2 2.5|
Peripheral, Degeneration, Fatty | 3 | 4 2.5|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Granuloma | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Accessory Spleen | | 1 |
Cytoplasmic Alteration, Focal | 2 | 1 2.0|
Fibrosis | | 1 4.0|
Acinus, Atrophy | 2 2 2 1 | 17 1.9|
Acinus, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + M + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach | + M + + + + + + + + | 59 |
Muscularis, Necrosis, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Forestomach | + M + + + + + + + + | 59 |
Acanthosis | 3 2 1 3 3 | 25 2.8|
Edema | 3 3 | 13 2.4|
Hyperkeratosis | 3 2 1 3 3 | 25 2.8|
Ulcer | 3 2 2 | 13 2.9|
Muscularis, Necrosis | 2 | 2 2.5|
Serosa, Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + M + + + + + + + + | 59 |
Dilatation | | 1 3.0|
Foreign Body | | 1 1.0|
Mucosa, Degeneration | 3 2 | 11 2.5|
Mucosa, Erosion, Focal | | 1 2.0|
Muscularis, Necrosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 13 |
Degeneration | 3 2 | 13 2.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Abscess | | 1 2.0|
Cardiomyopathy | 2 2 2 3 3 2 1 2 3 4 | 53 2.3|
Atrium, Dilatation | | 1 3.0|
Atrium, Thrombosis | X | 6 |
Myocardium, Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 7| 6| 5| 5| 6| 5| 6| | |
DAY ON TEST | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8| | |
| 0| 8| 2| 5| 6| 4| 4| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Angiectasis | | 1 2.0|
Degeneration, Fatty, Focal | 1 2 2 2 | 21 2.0|
Degeneration | 2 | 7 2.3|
Hyperplasia, Focal | 1 2 | 6 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Hyperplasia, Focal | 2 2 2 3 2 3 | 21 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
Hyperplasia, Focal | 1 | 1 1.0|
Hypertrophy | 3 3 3 4 4 | 32 2.8|
__________________________________________________________________________|____________|
Pituitary Gland | + M M + + + + + + + | 54 |
Pigmentation, Hemosiderin | | 1 4.0|
Pigmentation | | 1 3.0|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | 4 | 4 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 58 |
C-Cell, Hyperplasia | 1 | 7 1.9|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 4 |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 58 |
Degeneration, Focal | 3 4 3 3 3 | 35 2.9|
Fibrosis | 2 3 3 | 20 2.6|
__________________________________________________________________________|____________|
Penis | + | 6 |
Inflammation, Acute | 1 | 3 2.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | M M M + + + M + + + | 44 |
Abscess | | 2 3.5|
Ectasia | 3 | 4 2.5|
Fibrosis | 3 2 | 21 2.2|
Duct, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 7| 6| 5| 5| 6| 5| 6| | |
DAY ON TEST | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8| | |
| 0| 8| 2| 5| 6| 4| 4| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 58 |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 2 2 | 29 3.1|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 58 |
Atrophy | 2 2 3 | 15 2.6|
Depletion Cellular | 3 3 | 17 3.1|
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Hypoplasia | | 1 2.0|
Polyarteritis | | 3 3.0|
Interstitial Cell, Hyperplasia | | 4 1.0|
Seminiferous Tubule, Atrophy | 2 2 2 2 2 | 23 2.7|
Seminiferous Tubule, Degeneration | 2 3 3 | 14 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Hypoplasia | | 6 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Hemorrhage | | 1 1.0|
Mediastinal, Hemorrhage | 4 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + | 54 |
Hemorrhage | 4 | 3 3.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Congestion | | 3 3.0|
Depletion Lymphoid | | 1 3.0|
Fibrosis | | 4 2.8|
Hematopoietic Cell Proliferation | 3 3 3 | 8 2.6|
Pigmentation, Hemosiderin | 2 | 26 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + M | 45 |
Depletion Lymphoid | | 5 2.8|
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + | 54 |
Abscess | 4 | 1 4.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 7| 6| 5| 5| 6| 5| 6| | |
DAY ON TEST | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8| | |
| 0| 8| 2| 5| 6| 4| 4| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Lactation | X X X X X X X X | 39 |
Duct, Ectasia | | 1 3.0|
Duct, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Abdominal, Inflammation, Suppurative | | 1 1.0|
Other, Cyst Epithelial Inclusion | | 1 |
Other, Inflammation, Suppurative | 2 1 | 3 2.0|
Prepuce, Hyperkeratosis | | 1 2.0|
Prepuce, Inflammation | | 1 2.0|
Sebaceous Gland, Site of | | |
Application-Mass, Hyperplasia | | 1 2.0|
Site of Application-Mass, Fibrosis, | | |
Focal | | 1 2.0|
Site of Application-Mass, | | |
Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 60 |
Acanthosis | | 1 1.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 60 |
Acanthosis | | 2 1.5|
Cyst Epithelial Inclusion | | 3 |
Proliferation Connective Tissue | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Fibrous Osteodystrophy | X X X X | 22 |
Hypoplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Degeneration, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X | 5 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Atelectasis | | 2 2.0|
Congestion | 2 3 3 2 | 18 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 7| 6| 5| 5| 6| 5| 6| | |
DAY ON TEST | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8| | |
| 0| 8| 2| 5| 6| 4| 4| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 UL/RAT | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
UM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Inflammation, Chronic | 4 2 2 3 | 22 2.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | 2 3 2 | 3 2.3|
Fungus | | 4 4.0|
Infiltration Cellular, Diffuse, | | |
Lymphocyte | | 1 3.0|
Inflammation, Chronic | | 4 2.3|
Inflammation, Suppurative | | 7 1.9|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Hyperkeratosis | | 1 1.0|
__________________________________________________________________________|____________|
Eye | + + + + + + + + | 45 |
Cataract | 3 3 2 3 2 3 3 3 | 44 2.8|
Hemorrhage | 3 | 4 2.5|
Synechia | | 1 4.0|
Anterior Chamber, Hemorrhage | | 1 2.0|
Cornea, Inflammation | 3 | 5 2.6|
Retina, Atrophy | 3 3 2 3 1 2 | 36 2.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 3.0|
Nephropathy | 4 2 4 2 4 3 3 4 4 4 | 60 3.3|
Pelvis, Dilatation | | 1 2.0|
Pelvis, Epithelium, Hyperplasia | 2 2 2 2 2 2 2 | 30 2.2|
Pelvis, Epithelium, Inflammation | | 1 2.0|
Renal Tubule, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Hemorrhage | | 1 4.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Necrosis | | 1 3.0|
Mucosa, Hyperplasia | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 3| 3| 6| 7| 6| 7| 6| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 6| 2| 0| 5| 0| 0| 6| 3| 7| 3| 5| 2| 1| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 0| 4| 9| 1| 1| 5| 4| 3| 5| 4| 0| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
Parasite Metazoan | |
Muscularis, Necrosis, Focal | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
Mucosa, Erosion, Focal | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Angiectasis | |
Degeneration, Cystic, Focal | 3 |
Degeneration, Fatty | 2 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic, Focal | 2 2 1 |
Necrosis | 2 |
Bile Duct, Hyperplasia | 2 2 2 1 2 2 2 4 3 2 2 2 2 2|
Centrilobular, Degeneration, Fatty | 3 |
Peripheral, Degeneration, Fatty | |
__________________________________________________________________________|
Mesentery | |
Fat, Granuloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 |
Acinus, Atrophy | 3 3 2 3 2 |
Interlobular, Inflammation, Chronic | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
Muscularis, Necrosis, Focal | 2 |
Serosa, Inflammation, Necrotizing | 3 |
Serosa, Necrosis, Focal | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Acanthosis | 3 2 2 3 3|
Edema | 2 |
Hyperkeratosis | 2 2 3 2|
Ulcer | 2 2 |
Serosa, Inflammation, Suppurative | |
Serosa, Inflammation, Proliferative | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 3| 3| 6| 7| 6| 7| 6| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 6| 2| 0| 5| 0| 0| 6| 3| 7| 3| 5| 2| 1| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 0| 4| 9| 1| 1| 5| 4| 3| 5| 4| 0| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Fibrosis | 2 |
Epithelium, Degeneration | 3 |
Epithelium, Hyperplasia | 3 |
Mucosa, Degeneration | 2 3 |
Mucosa, Erosion, Focal | 3 |
__________________________________________________________________________|
Tooth | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + |
Degeneration | 3 3 2 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 2 4 4 2 2 2 2 2 1 2 3|
Atrium, Thrombosis | X X |
Myocardium, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Angiectasis | |
Cytoplasmic Alteration, Focal | |
Degeneration, Fatty, Focal | 3 2 3 |
Degeneration | 3 2 |
Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + +|
Hypertrophy | 3 3 3 3 3 2 3 3 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X |
Pars Distalis, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + +|
Degeneration, Focal | 3 3 1 4 2 4 4 4 4 3 3 3 3|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 3| 3| 6| 7| 6| 7| 6| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 6| 2| 0| 5| 0| 0| 6| 3| 7| 3| 5| 2| 1| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 0| 4| 9| 1| 1| 5| 4| 3| 5| 4| 0| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Fibrosis | 2 2 2 3 2 2 |
__________________________________________________________________________|
Penis | |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | M + + + + + + + + + + + + M +|
Abscess, Acute | |
Abscess | 3 |
Ectasia | 2 |
Fibrosis | 2 2 2 3 2 2|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 4 3 4 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 2 2 2|
Depletion Cellular | 4 2 4 3 3 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + +|
Hypoplasia | |
Polyarteritis | 2 3|
Interstitial Cell, Hyperplasia | 1 |
Seminiferous Tubule, Atrophy | 4 2 3 3 1 3 2 3 3 2 3 3|
Seminiferous Tubule, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Hypoplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 3 |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 2 2 2|
Infarct | |
Pigmentation, Hemosiderin | 2 3 3 2|
Capsule, Hyperplasia, Focal | |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + I I + +|
Depletion Lymphoid | 2 2 2 |
Hyperplasia, Pseudoepitheliomatous | 2 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 3| 3| 6| 7| 6| 7| 6| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 6| 2| 0| 5| 0| 0| 6| 3| 7| 3| 5| 2| 1| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 0| 4| 9| 1| 1| 5| 4| 3| 5| 4| 0| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + M + M + M M|
Galactocele | X |
Hyperplasia | |
Lactation | X X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Abdominal, Edema | 2 |
Abdominal, Exudate | X |
Foot, Hemorrhage | 4 |
Other, Inflammation, Acute | 1 |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 |
Exudate | 2|
Inflammation, Suppurative | 2|
Proliferation Connective Tissue | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X X X X X X X X|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Necrosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Compression | X X X X |
Hydrocephalus | 3 |
Infarct | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Atelectasis | |
Congestion | 2 3 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Acute | |
Inflammation, Chronic | 2 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Exudate | X |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 3| 3| 6| 7| 6| 7| 6| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 6| 2| 0| 5| 0| 0| 6| 3| 7| 3| 5| 2| 1| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 0| 4| 9| 1| 1| 5| 4| 3| 5| 4| 0| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fibrosis, Focal | |
Foreign Body | 4 2 2 |
Fungus | X |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 4 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + +|
Cataract | 3 3 3 3 3 3 3 3 3 2 3 3 2|
Hemorrhage | 3 3 |
Anterior Chamber, Inflammation, | |
Suppurative | |
Cornea, Inflammation | |
Retina, Atrophy | 3 3 3 3 2 2 3 3 3 2 3 3 3|
__________________________________________________________________________|
Zymbal's Gland | |
Abscess | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Nephropathy | 4 4 3 2 2 4 4 2 4 3 3 4 3 4 4|
Pelvis, Dilatation | |
Pelvis, Epithelium, Hyperplasia | 2 1 2 2 3 |
Pelvis, Epithelium, Mineralization | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 5| 7| 6| 4| 7| 5| 5| 5| 6| 5| 7| 5| 5| 7| 4| 7| 7| 7| 5| 5| 5|
DAY ON TEST | 5| 5| 6| 8| 5| 0| 0| 8| 1| 4| 8| 9| 9| 1| 3| 5| 4| 1| 9| 2| 3| 1| 6| 9| 2|
| 9| 3| 5| 7| 6| 4| 1| 6| 8| 3| 4| 1| 2| 9| 5| 9| 2| 6| 0| 3| 4| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 2|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + A + + + + A + + + + + + + + +|
Parasite Metazoan | X |
Muscularis, Necrosis, Focal | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Mucosa, Erosion, Focal | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + A + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Degeneration, Cystic, Focal | |
Degeneration, Fatty | 1 2 3 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic, Focal | 1 3 2 1 |
Necrosis | 2 3 |
Bile Duct, Hyperplasia | 2 2 2 1 3 1 2 2 2 2 2 3 3 1 2 2 2 2 |
Centrilobular, Degeneration, Fatty | 3 |
Peripheral, Degeneration, Fatty | 4 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Granuloma | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Acinus, Atrophy | 1 2 3 2 2 2 2 2 2 |
Interlobular, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Pharynx | +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Necrosis, Focal | 2 2 |
Serosa, Inflammation, Necrotizing | |
Serosa, Necrosis, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 4 4 3 2 3 4 |
Edema | 3 4 3 |
Hyperkeratosis | 3 3 4 3 3 2 3 4 |
Ulcer | 4 4 2 4 4 |
Serosa, Inflammation, Suppurative | |
Serosa, Inflammation, Proliferative | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 5| 7| 6| 4| 7| 5| 5| 5| 6| 5| 7| 5| 5| 7| 4| 7| 7| 7| 5| 5| 5|
DAY ON TEST | 5| 5| 6| 8| 5| 0| 0| 8| 1| 4| 8| 9| 9| 1| 3| 5| 4| 1| 9| 2| 3| 1| 6| 9| 2|
| 9| 3| 5| 7| 6| 4| 1| 6| 8| 3| 4| 1| 2| 9| 5| 9| 2| 6| 0| 3| 4| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Fibrosis | |
Epithelium, Degeneration | |
Epithelium, Hyperplasia | |
Mucosa, Degeneration | 2 3 |
Mucosa, Erosion, Focal | 3 |
__________________________________________________________________________|
Tooth | + |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + |
Degeneration | 2 2 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 1 2 3 2 1 2 1 2 1 3 4 3 2 3 2 2 2|
Atrium, Thrombosis | X X X |
Myocardium, Necrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cytoplasmic Alteration, Focal | |
Degeneration, Fatty, Focal | 2 1 3 2 2 2 3 1 2 2 2 2 2 2 |
Degeneration | |
Hyperplasia, Focal | 2 3 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 3 2 2 2 2 2 2 3 2 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hypertrophy | 3 3 2 3 3 2 2 3 3 3 2 4 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Pars Distalis, Hyperplasia, Focal | 1 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Epididymis | + + + + I + + + + + + + + + + A + + + + + + + + +|
Degeneration, Focal | 3 3 2 1 3 3 4 3 2 2 4 2 4 2 3 3 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 5| 7| 6| 4| 7| 5| 5| 5| 6| 5| 7| 5| 5| 7| 4| 7| 7| 7| 5| 5| 5|
DAY ON TEST | 5| 5| 6| 8| 5| 0| 0| 8| 1| 4| 8| 9| 9| 1| 3| 5| 4| 1| 9| 2| 3| 1| 6| 9| 2|
| 9| 3| 5| 7| 6| 4| 1| 6| 8| 3| 4| 1| 2| 9| 5| 9| 2| 6| 0| 3| 4| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Fibrosis | 3 2 3 3 2 2 2 2 |
__________________________________________________________________________|
Penis | + + |
Inflammation, Acute | 4 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + M + + + + + + M + +|
Abscess, Acute | 2|
Abscess | |
Ectasia | |
Fibrosis | 2 2 1 2 3 2 2 2 2 3 2 3 2|
Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 3 4 4 3 3 4 3 3 2 4 3 2 3 2 4 3 4|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 2 3 |
Depletion Cellular | 4 3 4 3 4 3 4 4 3 |
Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | |
Polyarteritis | 3 3 |
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 3 2 3 2 2 3 2 3 3 2 2 4 3 |
Seminiferous Tubule, Degeneration | 2 3 2 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hypoplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Congestion | |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | 3 3 2 2 |
Infarct | 3 |
Pigmentation, Hemosiderin | 2 2 3 2 3 2 2|
Capsule, Hyperplasia, Focal | |
Capsule, Hyperplasia | 3 |
__________________________________________________________________________|
Thymus | + + M + I + + M + M + + + I + + + + + + + M M + +|
Depletion Lymphoid | 2 |
Hyperplasia, Pseudoepitheliomatous | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 5| 7| 6| 4| 7| 5| 5| 5| 6| 5| 7| 5| 5| 7| 4| 7| 7| 7| 5| 5| 5|
DAY ON TEST | 5| 5| 6| 8| 5| 0| 0| 8| 1| 4| 8| 9| 9| 1| 3| 5| 4| 1| 9| 2| 3| 1| 6| 9| 2|
| 9| 3| 5| 7| 6| 4| 1| 6| 8| 3| 4| 1| 2| 9| 5| 9| 2| 6| 0| 3| 4| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M M + + M + + M + + + + + + M + + + M + M|
Galactocele | |
Hyperplasia | 3 3 |
Lactation | X X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abdominal, Edema | |
Abdominal, Exudate | |
Foot, Hemorrhage | |
Other, Inflammation, Acute | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 2 |
Exudate | |
Inflammation, Suppurative | |
Proliferation Connective Tissue | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + M + + + + + + + + +|
Fibrous Osteodystrophy | X 2 X X X X |
Hyperostosis | X |
__________________________________________________________________________|
Skeletal Muscle | |
Diaphragm, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Hydrocephalus | |
Infarct | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | 3 |
Congestion | 3 2 1 3 3 3 3 2 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 2 3 |
Inflammation, Acute | 3 |
Inflammation, Chronic | 2 4 2 4 3 2 1 3 3 3|
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 5| 7| 6| 4| 7| 5| 5| 5| 6| 5| 7| 5| 5| 7| 4| 7| 7| 7| 5| 5| 5|
DAY ON TEST | 5| 5| 6| 8| 5| 0| 0| 8| 1| 4| 8| 9| 9| 1| 3| 5| 4| 1| 9| 2| 3| 1| 6| 9| 2|
| 9| 3| 5| 7| 6| 4| 1| 6| 8| 3| 4| 1| 2| 9| 5| 9| 2| 6| 0| 3| 4| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fibrosis, Focal | 1 |
Foreign Body | 2 2 |
Fungus | X X |
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + |
Cataract | 3 3 3 3 3 2 3 3 2 3 2 3 3 2 3 3 3 3 3 3 |
Hemorrhage | 3 |
Anterior Chamber, Inflammation, | |
Suppurative | 3 |
Cornea, Inflammation | 2 3 3 2 |
Retina, Atrophy | 4 2 2 2 2 3 2 3 2 2 3 3 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
Abscess | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 4 2 4 4 4 3 4 3 2 4 2 2 4 2 4 3 3 4 2 4 3 4 4 3 2|
Pelvis, Dilatation | 2 |
Pelvis, Epithelium, Hyperplasia | 2 3 3 2 2 2 1 3 1 2 3 2 2 1 2 |
Pelvis, Epithelium, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6| | |
| 2| 4| 4| 9| 1| 3| 0| 4| 0| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + M + + | 49 |
Hyperkeratosis | | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 47 |
Parasite Metazoan | | 1 |
Muscularis, Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 49 |
Mucosa, Erosion, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Angiectasis | | 1 2.0|
Degeneration, Cystic, Focal | 2 2 | 3 2.3|
Degeneration, Fatty | 2 | 5 2.0|
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Chronic, Focal | 2 2 2 2 | 11 1.8|
Necrosis | | 3 2.3|
Bile Duct, Hyperplasia | 3 2 3 2 2 3 2 1 2 2 | 42 2.1|
Centrilobular, Degeneration, Fatty | | 2 3.0|
Peripheral, Degeneration, Fatty | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Granuloma | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Acinus, Atrophy | 3 1 3 | 17 2.2|
Interlobular, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
Muscularis, Necrosis, Focal | | 3 2.0|
Serosa, Inflammation, Necrotizing | | 1 3.0|
Serosa, Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Acanthosis | 4 2 3 3 3 4 3 3 | 21 3.0|
Edema | 3 4 3 3 2 | 9 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6| | |
| 2| 4| 4| 9| 1| 3| 0| 4| 0| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | 4 2 4 4 3 4 4 3 | 20 3.1|
Ulcer | 4 4 4 3 3 3 | 13 3.3|
Serosa, Inflammation, Suppurative | 4 | 1 4.0|
Serosa, Inflammation, Proliferative | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Fibrosis | | 1 2.0|
Epithelium, Degeneration | | 1 3.0|
Epithelium, Hyperplasia | | 1 3.0|
Mucosa, Degeneration | 3 | 5 2.6|
Mucosa, Erosion, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 8 |
Degeneration | | 7 2.6|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Cardiomyopathy | 1 2 3 2 2 3 2 2 2 2 | 44 2.2|
Atrium, Thrombosis | | 5 |
Myocardium, Necrosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Angiectasis | | 1 3.0|
Cytoplasmic Alteration, Focal | 2 | 1 2.0|
Degeneration, Fatty, Focal | 3 2 2 2 | 21 2.1|
Degeneration | 3 | 3 2.7|
Hyperplasia, Focal | 3 2 | 9 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Hyperplasia, Focal | 2 2 2 3 1 2 2 | 25 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 49 |
Hypertrophy | 4 3 2 2 2 2 3 3 | 30 2.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 49 |
Angiectasis | 4 | 1 4.0|
Cyst | X | 2 |
Pars Distalis, Hyperplasia, Focal | | 3 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6| | |
| 2| 4| 4| 9| 1| 3| 0| 4| 0| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 2 1 1 | 7 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 48 |
Degeneration, Focal | 3 4 2 4 3 3 3 3 3 | 38 3.0|
Fibrosis | 2 3 2 2 2 2 | 20 2.3|
__________________________________________________________________________|____________|
Penis | | 2 |
Inflammation, Acute | | 2 3.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 46 |
Abscess, Acute | | 1 2.0|
Abscess | | 1 3.0|
Ectasia | | 1 2.0|
Fibrosis | 2 2 2 3 | 23 2.2|
Inflammation, Chronic | 2 3 | 5 2.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 50 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | 3 3 2 4 | 25 3.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 50 |
Atrophy | 3 | 13 2.6|
Depletion Cellular | 3 3 3 4 3 3 2 | 21 3.3|
Inflammation, Suppurative | 3 | 4 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Hypoplasia | 2 | 1 2.0|
Polyarteritis | | 4 2.8|
Interstitial Cell, Hyperplasia | | 1 1.0|
Seminiferous Tubule, Atrophy | 2 3 1 4 2 3 | 31 2.6|
Seminiferous Tubule, Degeneration | 3 3 | 8 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 49 |
Hypoplasia | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Mediastinal, Angiectasis | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6| | |
| 2| 4| 4| 9| 1| 3| 0| 4| 0| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
Angiectasis | | 1 3.0|
Congestion | | 1 3.0|
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Fibrosis | 3 2 | 4 2.5|
Hematopoietic Cell Proliferation | 3 | 9 2.4|
Infarct | | 1 3.0|
Pigmentation, Hemosiderin | 2 2 2 | 14 2.3|
Capsule, Hyperplasia, Focal | 2 | 1 2.0|
Capsule, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M + I + + + + + M | 37 |
Depletion Lymphoid | | 4 2.0|
Hyperplasia, Pseudoepitheliomatous | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 38 |
Galactocele | | 1 |
Hyperplasia | 3 | 3 3.0|
Lactation | X X X X X X X X X X | 37 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 56 |
Abdominal, Edema | | 1 2.0|
Abdominal, Exudate | | 1 |
Foot, Hemorrhage | | 1 4.0|
Other, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 50 |
Cyst Epithelial Inclusion | | 1 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 55 |
Acanthosis | 1 2 | 10 1.2|
Exudate | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Proliferation Connective Tissue | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 49 |
Fibrous Osteodystrophy | X X X X X | 20 2.0|
Hyperostosis | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6| | |
| 2| 4| 4| 9| 1| 3| 0| 4| 0| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Diaphragm, Necrosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Compression | X | 8 |
Hydrocephalus | | 1 3.0|
Infarct | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Atelectasis | | 1 3.0|
Congestion | 2 2 2 | 13 2.4|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | | 3 2.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | 3 | 14 2.6|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Exudate | | 1 |
Fibrosis, Focal | | 1 1.0|
Foreign Body | | 5 2.4|
Fungus | 2 | 4 2.0|
Inflammation, Chronic | 2 2 | 5 2.0|
Inflammation, Suppurative | | 2 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + | 43 |
Cataract | 3 3 3 3 3 3 2 3 2 3 | 43 2.8|
Hemorrhage | 3 | 4 3.0|
Anterior Chamber, Inflammation, | | |
Suppurative | | 1 3.0|
Cornea, Inflammation | | 4 2.5|
Retina, Atrophy | 3 4 3 2 2 2 2 3 3 | 35 2.7|
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6| | |
| 2| 4| 4| 9| 1| 3| 0| 4| 0| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Abscess | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Nephropathy | 3 4 3 4 4 3 4 4 4 4 | 50 3.3|
Pelvis, Dilatation | 3 | 2 2.5|
Pelvis, Epithelium, Hyperplasia | 2 3 2 3 2 2 2 2 | 28 2.1|
Pelvis, Epithelium, Mineralization | | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 4| 7| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 6| 3| 3| 5| 3| 3| 3| 0| 3| 4| 5| 4| 2| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 5| 7| 7| 5| 9| 5| 5| 5| 8| 8| 5| 4| 7| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + +|
Edema | |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + +|
Edema | 3 |
Parasite Metazoan | X |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Degeneration, Cystic, Focal | 2 2 |
Degeneration, Fatty, Focal | 2 |
Degeneration, Fatty | 1 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic, Focal | 1 2 2 2 2 2 |
Inflammation, Focal, Granulomatous | 2 2 2 2 1 2 2 |
Necrosis | |
Bile Duct, Hyperplasia | 2 2 2 2 3 3 2 2 1 2 3 2 2 2 2 2 2 2 2 2 2 3|
Centrilobular, Degeneration, Fatty | 2 |
Midzonal, Degeneration, Fatty | |
Peripheral, Degeneration, Fatty | |
Serosa, Inflammation, Necrotizing | |
__________________________________________________________________________|
Mesentery | +|
Fat, Granuloma | 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Edema | |
Acinus, Atrophy | 3 2 2 2 1 3 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Necrosis, Focal | |
Muscularis, Necrosis | |
Serosa, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 4| 7| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 6| 3| 3| 5| 3| 3| 3| 0| 3| 4| 5| 4| 2| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 5| 7| 7| 5| 9| 5| 5| 5| 8| 8| 5| 4| 7| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 3 3 2 3 3 |
Edema | 3 |
Hyperkeratosis | 2 2 3 3 2 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Degeneration | 3 |
Mucosa, Erosion, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Degeneration | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 2 2 2 3 2 3 3 2 2 2 2 3 2 2 2 2 2 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty, Focal | 3 2 2 3 3 |
Degeneration | |
Hyperplasia, Focal | 1 2 1 |
Hypertrophy, Focal | |
Metaplasia, Focal, Osseous | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hypertrophy | 3 2 2 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | 4 |
Pigmentation | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 1 1 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemorrhage | 3 |
Inflammation, Proliferative | 4 |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 4| 7| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 6| 3| 3| 5| 3| 3| 3| 0| 3| 4| 5| 4| 2| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 5| 7| 7| 5| 9| 5| 5| 5| 8| 8| 5| 4| 7| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 3 3 2 2 3 3 3 2 1 3 3 |
Fibrosis | 3 2 |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + M + + + + M + + + + M|
Abscess | |
Ectasia | 2 |
Fibrosis | 3 2 2 2 3 2 |
Hyperplasia | |
Inflammation, Chronic | 2 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + M + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal | 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 3 3 3 3 3 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + M + + + + + + + + + +|
Atrophy | 3 3 3 |
Depletion Cellular | 4 4 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | |
Polyarteritis | 3 |
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 1 3 3 3 3 4 |
Seminiferous Tubule, Degeneration | 4 3 |
Unilateral, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + A + + + + + + + + + + + +|
Hypoplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + A + + + + + + + + I + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 1 |
Infarct | 3|
Pigmentation, Hemosiderin | 2 2 2 1 2 2 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M A + + M + + + M + + + M M|
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 4| 7| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 6| 3| 3| 5| 3| 3| 3| 0| 3| 4| 5| 4| 2| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 5| 7| 7| 5| 9| 5| 5| 5| 8| 8| 5| 4| 7| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Lymphoid | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + M + + + + + + + + + +|
Hyperplasia, Cystic | 4 |
Hyperplasia | 3 |
Lactation | X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abdominal, Subcutaneous Tissue, Edema| |
Other, Inflammation, Suppurative | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 1 2 1 1|
Hyperkeratosis | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X X X X |
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
Diaphragm, Inflammation, | |
Proliferative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage | 3 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 2 2 |
Edema | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic | 3 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + M + + + + + + + + + + + +|
Fungus | 3 4 |
Infiltration Cellular, Mixed Cell | 3 |
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Exudate | 2 |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 4| 7| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 6| 3| 3| 5| 3| 3| 3| 0| 3| 4| 5| 4| 2| 3|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 5| 7| 7| 5| 9| 5| 5| 5| 8| 8| 5| 4| 7| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Submucosa, Olfactory Epithelium, | |
Glands, Hypertrophy | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + |
Ulcer | 2 |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + +|
Cataract | 3 3 2 2 3 3 3 3 3 3 3 3 3|
Hemorrhage | |
Anterior Chamber, Inflammation, | |
Suppurative | 3 |
Retina, Atrophy | 3 2 3 3 2 2 3 3 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 3 3 3 2 3 3 3 3 2 2 2 2 4 3 3 2 3 4 4 3 3 4 4 2|
Pelvis, Epithelium, Hyperplasia | 2 2 2 3 4 3 |
Pelvis, Epithelium, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + M + + + + + + + + + +|
Inflammation, Chronic | 2|
Mucosa, Hyperplasia | 2|
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 7| 7| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 6| 5| 6| 6| 6| 5| 6| 3|
DAY ON TEST | 6| 9| 8| 4| 3| 1| 4| 5| 8| 9| 0| 1| 9| 2| 1| 3| 0| 6| 2| 3| 0| 1| 3| 5| 9|
| 2| 6| 9| 9| 4| 8| 2| 0| 2| 9| 0| 9| 9| 6| 2| 2| 8| 5| 8| 7| 7| 5| 4| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + A + + + + + + A A A + + + A|
Edema | 3 |
Ulcer | 3 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + A A + + + A|
Edema | |
Parasite Metazoan | |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + A A A + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + A|
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + A + + + + + + A A A A A + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + A + + + + + + A A A A A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Degeneration, Cystic, Focal | |
Degeneration, Fatty, Focal | |
Degeneration, Fatty | 1 |
Fibrosis, Focal | 2|
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic, Focal | 2 2 3 |
Inflammation, Focal, Granulomatous | |
Necrosis | 2 2 2 4 2 3 |
Bile Duct, Hyperplasia | 2 2 3 1 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Centrilobular, Degeneration, Fatty | |
Midzonal, Degeneration, Fatty | 2 |
Peripheral, Degeneration, Fatty | 3 |
Serosa, Inflammation, Necrotizing | 3 |
__________________________________________________________________________|
Mesentery | |
Fat, Granuloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Cytoplasmic Alteration, Focal | 2 |
Edema | 3 |
Acinus, Atrophy | 1 3 1 3 2 1 2 2 3 1 3 1 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Muscularis, Necrosis, Focal | 3 |
Muscularis, Necrosis | 2 |
Serosa, Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 7| 7| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 6| 5| 6| 6| 6| 5| 6| 3|
DAY ON TEST | 6| 9| 8| 4| 3| 1| 4| 5| 8| 9| 0| 1| 9| 2| 1| 3| 0| 6| 2| 3| 0| 1| 3| 5| 9|
| 2| 6| 9| 9| 4| 8| 2| 0| 2| 9| 0| 9| 9| 6| 2| 2| 8| 5| 8| 7| 7| 5| 4| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Acanthosis | 4 2 2 2 4 3 3 3 3 2 2 |
Edema | 2 2 3 2 2 |
Hyperkeratosis | 3 2 3 2 2 4 3 3 3 2 2 2 |
Ulcer | 2 3 3 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
Mucosa, Degeneration | 3 3 3 |
Mucosa, Erosion, Focal | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Degeneration | 3 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 3 1 2 2 3 2 2 2 2 2 1 3 2 1 2 2 3 2 1 |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty, Focal | 2 2 2 2 4 2 3 2 2 |
Degeneration | |
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | |
Metaplasia, Focal, Osseous | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 3 3 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Hypertrophy | 2 3 4 1 2 2 4 2 3 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + I + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hemorrhage | 4 |
Pigmentation | 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
C-Cell, Hyperplasia | 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage | |
Inflammation, Proliferative | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 7| 7| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 6| 5| 6| 6| 6| 5| 6| 3|
DAY ON TEST | 6| 9| 8| 4| 3| 1| 4| 5| 8| 9| 0| 1| 9| 2| 1| 3| 0| 6| 2| 3| 0| 1| 3| 5| 9|
| 2| 6| 9| 9| 4| 8| 2| 0| 2| 9| 0| 9| 9| 6| 2| 2| 8| 5| 8| 7| 7| 5| 4| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 2 3 4 3 3 2 3 4 3 3 3 3 4 |
Fibrosis | 2 2 2 2 3 2 |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Abscess | 4 3 |
Ectasia | 2 3 |
Fibrosis | 2 3 3 2 2 2 2 2 2 3 2 2 3 |
Hyperplasia | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal | 2 |
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | 3 3 3 4 3 3 4 3 4 3 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + A|
Atrophy | 3 2 2 3 2 2 |
Depletion Cellular | 3 2 3 3 4 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | |
Polyarteritis | 3 3 |
Interstitial Cell, Hyperplasia | 3 1 |
Seminiferous Tubule, Atrophy | 4 4 2 3 3 1 2 2 2 2 3 |
Seminiferous Tubule, Degeneration | 3 3 3 3 |
Unilateral, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hypoplasia | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A|
Congestion | 4 |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 4 2 3 3 |
Infarct | 4 |
Pigmentation, Hemosiderin | 2 2 3 2 3 2 2 2 |
__________________________________________________________________________|
Thymus | + + + M M + M + + + + I + + + + + I + + M M M M +|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 7| 7| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 6| 5| 6| 6| 6| 5| 6| 3|
DAY ON TEST | 6| 9| 8| 4| 3| 1| 4| 5| 8| 9| 0| 1| 9| 2| 1| 3| 0| 6| 2| 3| 0| 1| 3| 5| 9|
| 2| 6| 9| 9| 4| 8| 2| 0| 2| 9| 0| 9| 9| 6| 2| 2| 8| 5| 8| 7| 7| 5| 4| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Lymphoid | 2 3 2 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + M + + + + + +|
Hyperplasia, Cystic | |
Hyperplasia | 3 |
Lactation | X X X X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abdominal, Subcutaneous Tissue, Edema| |
Other, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 1 1 1 2 |
Hyperkeratosis | 2 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + M + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X X X X X X |
Hyperostosis | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Inflammation, | |
Proliferative | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X|
Hemorrhage | |
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 2 2 2 2 3 2 4|
Edema | 4|
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 2|
Inflammation, Chronic | 2 3 1 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X X X X |
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic | 2 2 2 |
Inflammation, Suppurative | 3 2 2 2 1 |
Nasolacrimal Duct, Exudate | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 7| 7| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 6| 5| 6| 6| 6| 5| 6| 3|
DAY ON TEST | 6| 9| 8| 4| 3| 1| 4| 5| 8| 9| 0| 1| 9| 2| 1| 3| 0| 6| 2| 3| 0| 1| 3| 5| 9|
| 2| 6| 9| 9| 4| 8| 2| 0| 2| 9| 0| 9| 9| 6| 2| 2| 8| 5| 8| 7| 7| 5| 4| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
300 UL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
Submucosa, Olfactory Epithelium, | |
Glands, Hypertrophy | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Ulcer | |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + |
Cataract | 3 2 3 2 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 |
Hemorrhage | 3 |
Anterior Chamber, Inflammation, | |
Suppurative | |
Retina, Atrophy | 3 2 3 3 2 3 2 2 3 3 2 3 3 2 3 4 3 3 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 4 2 4 3 2 4 2 4 4 4 3 2 4 2 2 2 4 4 2 2 2 2 1 2 3|
Pelvis, Epithelium, Hyperplasia | 2 3 2 3 2 3 2 2 1 2 |
Pelvis, Epithelium, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 5| 6| 6| 5| 5| 5| | |
DAY ON TEST | 6| 8| 3| 2| 3| 4| 1| 3| 8| 6| | |
| 8| 6| 4| 8| 5| 1| 2| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Hyperkeratosis | | 4 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A A + | 50 |
Edema | | 1 3.0|
Ulcer | | 3 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + | 53 |
Edema | 2 | 2 2.5|
Parasite Metazoan | | 1 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + M + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Clear Cell Focus | | 1 |
Degeneration, Cystic, Focal | | 2 2.0|
Degeneration, Fatty, Focal | | 1 2.0|
Degeneration, Fatty | | 2 1.0|
Fibrosis, Focal | 2 | 2 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Chronic, Focal | 2 2 1 | 12 1.9|
Inflammation, Focal, Granulomatous | | 7 1.9|
Necrosis | | 6 2.5|
Bile Duct, Hyperplasia | 2 2 2 3 2 2 3 2 | 47 2.1|
Centrilobular, Degeneration, Fatty | | 1 2.0|
Midzonal, Degeneration, Fatty | | 1 2.0|
Peripheral, Degeneration, Fatty | | 1 3.0|
Serosa, Inflammation, Necrotizing | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Granuloma | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Edema | 2 | 2 2.5|
Acinus, Atrophy | 3 1 3 3 | 26 2.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 5| 6| 6| 5| 5| 5| | |
DAY ON TEST | 6| 8| 3| 2| 3| 4| 1| 3| 8| 6| | |
| 8| 6| 4| 8| 5| 1| 2| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Concretion | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 59 |
Muscularis, Necrosis, Focal | | 1 3.0|
Muscularis, Necrosis | | 1 2.0|
Serosa, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Acanthosis | 2 1 3 3 3 2 | 24 2.6|
Edema | 2 2 2 2 | 10 2.2|
Hyperkeratosis | 2 1 3 3 3 2 | 24 2.5|
Ulcer | 4 2 4 | 8 3.1|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Mucosa, Degeneration | | 4 3.0|
Mucosa, Erosion, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Degeneration | | 2 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Cardiomyopathy | 2 2 2 2 2 2 1 | 52 2.0|
Atrium, Thrombosis | X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Degeneration, Fatty, Focal | 2 | 15 2.4|
Degeneration | 1 | 1 1.0|
Hyperplasia, Focal | 3 2 1 | 8 1.8|
Hypertrophy, Focal | 2 | 1 2.0|
Metaplasia, Focal, Osseous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 57 |
Hyperplasia, Focal | 1 4 2 | 14 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 49 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + | 57 |
Hyperplasia, Focal | | 1 1.0|
Hypertrophy | 2 3 2 | 19 2.6|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Angiectasis | | 1 2.0|
Hemorrhage | | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 5| 6| 6| 5| 5| 5| | |
DAY ON TEST | 6| 8| 3| 2| 3| 4| 1| 3| 8| 6| | |
| 8| 6| 4| 8| 5| 1| 2| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pigmentation | | 1 3.0|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 | 10 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + + + + | 57 |
C-Cell, Hyperplasia | 1 1 | 8 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Hemorrhage | | 1 3.0|
Inflammation, Proliferative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
Degeneration, Focal | 4 1 2 3 3 1 2 | 31 2.7|
Fibrosis | 3 2 2 | 11 2.3|
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + M + | 54 |
Abscess | | 2 3.5|
Ectasia | 3 | 4 2.5|
Fibrosis | 2 2 2 3 2 | 24 2.3|
Hyperplasia | | 1 3.0|
Inflammation, Chronic | | 3 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 58 |
Cyst | 4 | 1 4.0|
Hyperplasia, Focal | 2 | 3 2.0|
Inflammation, Chronic | | 2 2.0|
Inflammation, Suppurative | 2 3 3 4 4 3 4 3 | 27 3.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 58 |
Atrophy | 2 2 3 | 12 2.5|
Depletion Cellular | 3 3 | 10 3.2|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
Hypoplasia | 2 | 1 2.0|
Polyarteritis | 3 | 4 3.0|
Interstitial Cell, Hyperplasia | | 3 2.0|
Seminiferous Tubule, Atrophy | 3 2 2 | 20 2.6|
Seminiferous Tubule, Degeneration | 3 3 | 8 3.1|
Unilateral, Atrophy | | 2 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 5| 6| 6| 5| 5| 5| | |
DAY ON TEST | 6| 8| 3| 2| 3| 4| 1| 3| 8| 6| | |
| 8| 6| 4| 8| 5| 1| 2| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 57 |
Hypoplasia | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
Mediastinal, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 55 |
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Congestion | | 3 3.3|
Fibrosis | 4 3 | 4 3.0|
Hematopoietic Cell Proliferation | 2 | 7 2.6|
Infarct | | 2 3.5|
Pigmentation, Hemosiderin | 2 2 | 23 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 44 |
Depletion Lymphoid | | 7 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + + + M + + | 52 |
Hyperplasia, Cystic | | 1 4.0|
Hyperplasia | | 2 3.0|
Lactation | X X X X X X | 40 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Abdominal, Subcutaneous Tissue, Edema| 3 | 1 3.0|
Other, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 60 |
Acanthosis | 1 1 1 1 1 | 27 1.1|
Hyperkeratosis | 1 | 2 1.5|
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 58 |
Fibrous Osteodystrophy | X | 11 |
Hyperostosis | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Diaphragm, Inflammation, | | |
Proliferative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 5| 6| 6| 5| 5| 5| | |
DAY ON TEST | 6| 8| 3| 2| 3| 4| 1| 3| 8| 6| | |
| 8| 6| 4| 8| 5| 1| 2| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Compression | X X | 9 |
Hemorrhage | | 1 3.0|
Hydrocephalus | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 2 2 2 3 | 19 2.2|
Edema | | 1 4.0|
Hemorrhage | 1 | 2 1.5|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Chronic | 1 3 | 11 2.0|
Alveolar Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
Fungus | X | 7 3.5|
Infiltration Cellular, Mixed Cell | | 1 3.0|
Inflammation, Chronic | | 5 2.0|
Inflammation, Suppurative | 3 | 7 2.1|
Nasolacrimal Duct, Exudate | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.0|
Submucosa, Olfactory Epithelium, | | |
Glands, Hypertrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Eye | + + + + + + + + | 42 |
Cataract | 3 3 3 3 3 3 3 3 | 42 2.9|
Hemorrhage | | 1 3.0|
Anterior Chamber, Inflammation, | | |
Suppurative | | 1 3.0|
Retina, Atrophy | 3 3 3 3 3 2 | 34 2.7|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05106-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 16:40:05
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 5| 6| 6| 5| 5| 5| | |
DAY ON TEST | 6| 8| 3| 2| 3| 4| 1| 3| 8| 6| | |
| 8| 6| 4| 8| 5| 1| 2| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
300 UL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
RAT HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy | 3 2 3 2 2 4 3 4 2 3 | 60 2.9|
Pelvis, Epithelium, Hyperplasia | 2 2 2 2 2 1 | 22 2.2|
Pelvis, Epithelium, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 56 |
Inflammation, Chronic | | 1 2.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
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---------- END OF REPORT ----------
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