TDMS Study 05106-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Hazelton, MD DIETHYLPHTHALATE DATE: 05/19/95
EXPERIMENT: 05106 TEST: 01 TIME: 20:59:28
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1ES45036 ROUTE: SKIN APPLICATION NTP C#: 60048B
PATHOLOGIST: R. CARDY CAS: 84-66-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Hazelton, MD DIETHYLPHTHALATE DATE: 05/19/95
EXPERIMENT: 05106 TEST: 01 TIME: 20:59:28
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1ES45036 ROUTE: SKIN APPLICATION NTP C#: 60048B
PATHOLOGIST: R. CARDY CAS: 84-66-2
DIETHYLPHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0UL/RAT UM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 46 CENSORED DEATHS 10 TERMINAL 4 |
| |
| UNCENSORED DEATHS |
| 264 399 478 502 502 520 524 527 528 548 |
| 549 568 568 571 578 582 583 587 591 594 |
| 596 597 598 600 619 626 629 629 636 636 |
| 644 646 651 652 668 671 673 674 680 681 |
| 687 691 699 702 709 730 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100UL RAT |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 44 CENSORED DEATHS 10 TERMINAL 6 |
| |
| UNCENSORED DEATHS |
| 304 359 486 490 519 528 542 543 553 556 |
| 559 559 560 580 584 591 597 601 601 616 |
| 620 620 639 640 640 652 653 654 654 654 |
| 665 665 666 668 673 687 692 701 701 704 |
| 716 718 718 723 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300UL RAT |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 45 CENSORED DEATHS 9 TERMINAL 6 |
| |
| UNCENSORED DEATHS |
| 391 413 437 486 512 519 528 533 534 534 |
| 535 538 542 549 559 562 563 580 582 596 |
| 607 612 615 626 632 637 641 645 645 647 |
| 650 650 654 665 667 668 689 699 699 700 |
| 708 708 718 722 728 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
DIETHYLPHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0UL/RAT UM | 100.0 100.0 98.3 98.3 96.7 94.7 82.6 52.4 32.2 8.1 |
| | |
| | |
|100UL RAT| 100.0 100.0 100.0 96.7 96.7 96.7 84.6 62.4 36.3 12.1 |
| | |
| | |
|300UL RAT| 100.0 100.0 100.0 100.0 96.7 95.0 75.2 61.4 33.6 11.9 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0UL/RAT UM 100UL RAT 300UL RAT |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 8.1% 12.1% 11.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.640N P=0.313N P=0.545N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 599.7 610.3 602.8 |
|NATURAL DEATHS (C) | (12.7) (13.4) (12.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 584.7 596.9 593.9 |
|(STANDARD ERROR) | (13.0) (13.7) (13.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIETHYLPHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0UL/RAT UF |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 9 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 331 458 465 551 552 555 562 569 569 593 |
| 612 650 655 656 679 683 705 717 724 730 |
| 731 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100UL RAT |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 419 434 494 545 551 555 567 568 573 574 |
| 600 640 645 650 654 655 659 673 675 687 |
| 713 733 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300UL RAT |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 27 CENSORED DEATHS 10 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 344 367 430 489 520 541 543 549 559 569 |
| 584 585 588 591 595 611 626 638 639 657 |
| 658 675 680 687 689 706 729 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
DIETHYLPHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0UL/RAT UF | 100.0 100.0 100.0 98.3 98.3 94.4 94.4 80.6 72.8 59.0 |
| | |
| | |
|100UL RAT| 100.0 100.0 100.0 100.0 98.3 96.7 92.6 78.5 66.5 56.4 |
| | |
| | |
|300UL RAT| 100.0 100.0 100.0 98.3 96.7 95.0 86.9 70.7 58.6 46.5 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0UL/RAT UF 100UL RAT 300UL RAT |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 59.0% 56.4% 46.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.162 P=0.835 P=0.202 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 607.0 602.9 587.0 |
|NATURAL DEATHS (C) | (22.7) (17.8) (18.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 647.9 639.6 621.5 |
|(STANDARD ERROR) | (15.1) (14.7) (15.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIETHYLPHTHALATE
KAPLAN-MEIER SURVIVAL CURVES
0UL/RAT UM = 1
100UL RAT = 2
300UL RAT = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
| 1 2 2 31 3 3 12
| 3 13 1
| 2 3 2
90 + 1 3 12
| 1132
| 22
| 1 12
80 +
| 331 1
| 332 2
| 333112
P 70 + 11 2
E | 3 3 22
R | 31 1
C | 3 232
E 60 + 11322
N | 2 2
T | 3 3
| 1 133
S 50 + 1132 2
U | 33
R | 11
V |
I 40 + 11 2 2
V | 113 22
A | 11 3
L | 1 312
30 + 32 2
| 11 33
| 112 2
| 3 3
20 + 11 2 2
| 33
| 111 22
| 11 2 2
10 + 1 1
| 1
|
|
0 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 31 obs hidden.
DIETHYLPHTHALATE
KAPLAN-MEIER SURVIVAL CURVES
0UL/RAT UF = 1
100UL RAT = 2
300UL RAT = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
| 1 3 3 2 2 11 2
| 3 1 32 21
| 3 3 22
P 90 + 3 311
E | 33111
R | 33
C | 3 1 1
E 80 + 2 3 12 1
N | 2 1 211
T | 3 3
| 21 1
S 70 + 3 3 11 1
U | 3 3 3 2 2 2 1 1
R | 11
V | 3 3 2 2 1 1
I 60 + 2 2 1
V | 3 33 2 2
A | 33
L |
50 + 3 3
| 3 3
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 25 obs hidden.