TDMS Study 05107-05 Pathology Tables
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
Core Animals
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 12035722
Lock Date: 09/30/92
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 5| 7| 3| 7| 5| 6| 7| 7| 6| 5| 6| 2| 7| 6| 7| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 4| 1| 7| 1| 3| 6| 3| 0| 6| 3| 3| 4| 6| 6| 6| 3| 1| 3| 7| 3| 3| 3| 6| 3|
| 0| 0| 7| 8| 3| 0| 9| 1| 0| 4| 0| 0| 0| 3| 5| 3| 2| 3| 1| 4| 0| 0| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
0.0MG/M3 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0|
| 1| 2| 3| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M A + + + + + + + + A + + + + + + + I +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Schwannoma NOS | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + M + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + M + + + + + + + + M + + + + + + + + +|
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 5| 7| 3| 7| 5| 6| 7| 7| 6| 5| 6| 2| 7| 6| 7| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 4| 1| 7| 1| 3| 6| 3| 0| 6| 3| 3| 4| 6| 6| 6| 3| 1| 3| 7| 3| 3| 3| 6| 3|
| 0| 0| 7| 8| 3| 0| 9| 1| 0| 4| 0| 0| 0| 3| 5| 3| 2| 3| 1| 4| 0| 0| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
0.0MG/M3 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0|
| 1| 2| 3| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + M + + + I + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + M + + + + + + + + + + I + + + I +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + I + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M + + + M + + I + + + + + I + M + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Thymus | I + + + + + M + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Fibroadenoma | X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pinna, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + I + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 5| 7| 3| 7| 5| 6| 7| 7| 6| 5| 6| 2| 7| 6| 7| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 4| 1| 7| 1| 3| 6| 3| 0| 6| 3| 3| 4| 6| 6| 6| 3| 1| 3| 7| 3| 3| 3| 6| 3|
| 0| 0| 7| 8| 3| 0| 9| 1| 0| 4| 0| 0| 0| 3| 5| 3| 2| 3| 1| 4| 0| 0| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
0.0MG/M3 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0|
| 1| 2| 3| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Nephroblastoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 3| 7| 6| 7| 7| 5| 7| 4|
DAY ON TEST | 4| 3| 3| 2| 3| 3| 1| 3| 3| 7| 3| 3| 4| 6| 3| 2| 5| 7| 2| 9| 2| 2| 7| 2| 7|
| 0| 1| 1| 9| 8| 2| 6| 1| 1| 7| 2| 2| 2| 7| 0| 9| 7| 7| 1| 6| 9| 9| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 2| 3| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + M + M I + + + + + I + M + + + M + M + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Schwannoma NOS | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 3| 7| 6| 7| 7| 5| 7| 4|
DAY ON TEST | 4| 3| 3| 2| 3| 3| 1| 3| 3| 7| 3| 3| 4| 6| 3| 2| 5| 7| 2| 9| 2| 2| 7| 2| 7|
| 0| 1| 1| 9| 8| 2| 6| 1| 1| 7| 2| 2| 2| 7| 0| 9| 7| 7| 1| 6| 9| 9| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 2| 3| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 3| 4|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node | + +|
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + I + + + + + + M + M + + + M + + + + + + + M +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Thymus | I + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
Fibroadenoma | X X X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pinna, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 3| 7| 6| 7| 7| 5| 7| 4|
DAY ON TEST | 4| 3| 3| 2| 3| 3| 1| 3| 3| 7| 3| 3| 4| 6| 3| 2| 5| 7| 2| 9| 2| 2| 7| 2| 7|
| 0| 1| 1| 9| 8| 2| 6| 1| 1| 7| 2| 2| 2| 7| 0| 9| 7| 7| 1| 6| 9| 9| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 2| 3| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 3| 4|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Nephroblastoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 7| 4| 7| | |
DAY ON TEST | 3| 7| 3| | |
| 1| 7| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.0MG/M3 | 3| 3| 4| | L |
| 5| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 41 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Leukemia Mononuclear | | 18 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | | 2 |
Schwannoma NOS | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Leukemia Mononuclear | | 3 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Leukemia Mononuclear | | 2 |
Pars Distalis, Adenoma | X X | 24 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 51 |
C-Cell, Adenoma | | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 7| 4| 7| | |
DAY ON TEST | 3| 7| 3| | |
| 1| 7| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.0MG/M3 | 3| 3| 4| | L |
| 5| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + | 52 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Granulosa Cell Tumor Benign | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Polyp Stromal | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Lymph Node | | 5 |
Iliac, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 3 |
Renal, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 50 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 44 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 52 |
Leukemia Mononuclear | | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 46 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Leukemia Mononuclear | | 19 |
__________________________________________________________________________|____________|
Thymus | + + + | 49 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Adenoma | | 1 |
Carcinoma | | 1 |
Fibroadenoma | X X | 22 |
__________________________________________________________________________|____________|
Skin | + + + | 53 |
Pinna, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 7| 4| 7| | |
DAY ON TEST | 3| 7| 3| | |
| 1| 7| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.0MG/M3 | 3| 3| 4| | L |
| 5| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 52 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Adenoma | | 1 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | | 16 |
__________________________________________________________________________|____________|
Nose | + + + | 53 |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Leukemia Mononuclear | | 1 |
Nephroblastoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | | 19 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 5| 7| 6| 6|
DAY ON TEST | 3| 2| 2| 2| 2| 2| 8| 3| 2| 3| 8| 2| 0| 3| 9| 9| 3| 5| 2| 2| 3| 3| 2| 1| 3|
| 0| 9| 2| 9| 1| 9| 2| 2| 9| 2| 2| 9| 9| 0| 9| 0| 0| 3| 9| 9| 1| 8| 9| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.15 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
MG/M3 | 1| 2| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + M + + + + + I + + + + M + M + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Gingiva, Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Schwannoma NOS | X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | I + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | +|
Mediastinum, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 5| 7| 6| 6|
DAY ON TEST | 3| 2| 2| 2| 2| 2| 8| 3| 2| 3| 8| 2| 0| 3| 9| 9| 3| 5| 2| 2| 3| 3| 2| 1| 3|
| 0| 9| 2| 9| 1| 9| 2| 2| 9| 2| 2| 9| 9| 0| 9| 0| 0| 3| 9| 9| 1| 8| 9| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.15 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
MG/M3 | 1| 2| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
Mediastinum, Squamous Cell Carcinoma,| |
Metastatic, Lung | X|
Thoracic, Squamous Cell Carcinoma, | |
Metastatic, Lung | X|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa-Theca Tumor Benign | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Polyp Stromal | |
__________________________________________________________________________|
Vagina | + |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node | |
Inguinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + M + + + + + + + I + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + M + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 5| 7| 6| 6|
DAY ON TEST | 3| 2| 2| 2| 2| 2| 8| 3| 2| 3| 8| 2| 0| 3| 9| 9| 3| 5| 2| 2| 3| 3| 2| 1| 3|
| 0| 9| 2| 9| 1| 9| 2| 2| 9| 2| 2| 9| 9| 0| 9| 0| 0| 3| 9| 9| 1| 8| 9| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.15 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
MG/M3 | 1| 2| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Tooth | |
__________________________________________________________________________|
Skeletal Muscle | |
Squamous Cell Carcinoma, Metastatic, | |
Tooth | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Leukemia Mononuclear | X X X X X X |
Squamous Cell Carcinoma | X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 6| 6| 6| 5| 5|
DAY ON TEST | 4| 3| 2| 5| 0| 2| 2| 3| 4| 3| 4| 2| 3| 9| 2| 3| 3| 3| 9| 8| 0| 7| 2| 6| 9|
| 9| 1| 7| 2| 6| 9| 9| 1| 2| 1| 0| 9| 1| 4| 0| 0| 2| 0| 5| 1| 9| 8| 0| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.15 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/M3 | 3| 4| 5| 6| 7| 1| 3| 4| 5| 6| 7| 8| 0| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + A + + + M + + + + + M + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Gingiva, Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Schwannoma NOS | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Mediastinum, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 6| 6| 6| 5| 5|
DAY ON TEST | 4| 3| 2| 5| 0| 2| 2| 3| 4| 3| 4| 2| 3| 9| 2| 3| 3| 3| 9| 8| 0| 7| 2| 6| 9|
| 9| 1| 7| 2| 6| 9| 9| 1| 2| 1| 0| 9| 1| 4| 0| 0| 2| 0| 5| 1| 9| 8| 0| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.15 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/M3 | 3| 4| 5| 6| 7| 1| 3| 4| 5| 6| 7| 8| 0| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 7|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
Mediastinum, Squamous Cell Carcinoma,| |
Metastatic, Lung | |
Thoracic, Squamous Cell Carcinoma, | |
Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa-Theca Tumor Benign | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Polyp Stromal | X |
__________________________________________________________________________|
Vagina | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + |
Inguinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + M +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X|
Fibroadenoma | X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 6| 6| 6| 5| 5|
DAY ON TEST | 4| 3| 2| 5| 0| 2| 2| 3| 4| 3| 4| 2| 3| 9| 2| 3| 3| 3| 9| 8| 0| 7| 2| 6| 9|
| 9| 1| 7| 2| 6| 9| 9| 1| 2| 1| 0| 9| 1| 4| 0| 0| 2| 0| 5| 1| 9| 8| 0| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.15 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/M3 | 3| 4| 5| 6| 7| 1| 3| 4| 5| 6| 7| 8| 0| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 7|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Tooth | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Squamous Cell Carcinoma, Metastatic, | |
Tooth | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Leukemia Mononuclear | X X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 7| 6| 7| | |
DAY ON TEST | 1| 3| 3| | |
| 8| 5| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.15 | 7| 7| 8| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + M | 40 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 52 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Leukemia Mononuclear | X | 17 |
__________________________________________________________________________|____________|
Pancreas | + + + | 52 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Gingiva, Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | | 3 |
Schwannoma NOS | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Leukemia Mononuclear | | 3 |
Pheochromocytoma Benign | | 6 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Adenoma | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X | 30 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
C-Cell, Adenoma | | 4 |
C-Cell, Carcinoma | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 7| 6| 7| | |
DAY ON TEST | 1| 3| 3| | |
| 8| 5| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.15 | 7| 7| 8| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Mediastinum, Leukemia Mononuclear | | 1 |
Mediastinum, Squamous Cell Carcinoma,| | |
Metastatic, Lung | | 1 |
Thoracic, Squamous Cell Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + | 52 |
Adenoma | | 2 |
Carcinoma | | 3 |
__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Granulosa-Theca Tumor Benign | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Adenoma | | 1 |
Polyp Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Leukemia Mononuclear | | 8 |
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Inguinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + | 49 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + I + | 50 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + I + | 50 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 7| 6| 7| | |
DAY ON TEST | 1| 3| 3| | |
| 8| 5| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.15 | 7| 7| 8| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 17 |
__________________________________________________________________________|____________|
Thymus | + + + | 51 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Carcinoma | X | 3 |
Fibroadenoma | | 11 |
__________________________________________________________________________|____________|
Skin | + + + | 53 |
Fibrosarcoma | | 1 |
Subcutaneous Tissue, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
Squamous Cell Carcinoma, Metastatic, | | |
Tooth | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Astrocytoma NOS | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 53 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma | | 5 |
Leukemia Mononuclear | | 8 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Nose | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 7| 6| 7| | |
DAY ON TEST | 1| 3| 3| | |
| 8| 5| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.15 | 7| 7| 8| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | X | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 3| 2| 4| 3| 3| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6| 3| 2| 0| 3|
| 3| 2| 3| 1| 9| 1| 1| 5| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3| 1| 9| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|
MG/M3 | 1| 2| 4| 6| 7| 8| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M M + + + + + M + M + + + M + + + M|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X X |
Bilateral, Pheochromocytoma Benign | X X X X X X X X X X X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + M + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 3| 2| 4| 3| 3| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6| 3| 2| 0| 3|
| 3| 2| 3| 1| 9| 1| 1| 5| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3| 1| 9| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|
MG/M3 | 1| 2| 4| 6| 7| 8| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | + |
Thoracic, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | X X X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Axillary, Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Histiocytic Sarcoma | |
Iliac, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X X X X |
Renal, Histiocytic Sarcoma | |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + M + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + M|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 3| 2| 4| 3| 3| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6| 3| 2| 0| 3|
| 3| 2| 3| 1| 9| 1| 1| 5| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3| 1| 9| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|
MG/M3 | 1| 2| 4| 6| 7| 8| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Keratoacanthoma | X |
Pinna, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + I + + + + + I + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 3| 2| 4| 3| 3| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6| 3| 2| 0| 3|
| 3| 2| 3| 1| 9| 1| 1| 5| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3| 1| 9| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|
MG/M3 | 1| 2| 4| 6| 7| 8| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 3| 8| 2| 2| 3| 3| 6|
| 9| 0| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 1| 1| 9| 9| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
MG/M3 | 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + M + + M M + + + + + + + + + + I M + M|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Mesentery | |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X|
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X |
Bilateral, Pheochromocytoma Benign | X X X X X X X X X X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + M + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
Pars Distalis, Adenoma | X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + I + + + + +|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 3| 8| 2| 2| 3| 3| 6|
| 9| 0| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 1| 1| 9| 9| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
MG/M3 | 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 5| 6|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | |
Thoracic, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Adenoma | X |
Carcinoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Lymph Node | + + +|
Axillary, Leukemia Mononuclear | X |
Deep Cervical, Leukemia Mononuclear | X |
Iliac, Histiocytic Sarcoma | |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X X|
Renal, Histiocytic Sarcoma | |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + I + + + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M + + I + + M + + M + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 3| 8| 2| 2| 3| 3| 6|
| 9| 0| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 1| 1| 9| 9| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
MG/M3 | 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Keratoacanthoma | |
Pinna, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 3| 8| 2| 2| 3| 3| 6|
| 9| 0| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 1| 1| 9| 9| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
MG/M3 | 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 5| 6|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 5| 7| | |
DAY ON TEST | 9| 8| 2| | |
| 4| 2| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1.0 | 1| 1| 1| | L |
MG/M3 | 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M M | 38 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X | 21 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X | 6 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X | 12 |
Bilateral, Pheochromocytoma Benign | X | 24 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 5| 7| | |
DAY ON TEST | 9| 8| 2| | |
| 4| 2| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1.0 | 1| 1| 1| | L |
MG/M3 | 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 4 |
Pars Distalis, Adenoma | X | 15 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
C-Cell, Adenoma | | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Thoracic, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + | 52 |
Adenoma | | 1 |
Carcinoma | | 3 |
__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Cystadenoma | | 1 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Leukemia Mononuclear | | 2 |
Polyp Stromal | | 3 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Lymph Node | + | 10 |
Axillary, Leukemia Mononuclear | | 1 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Iliac, Histiocytic Sarcoma | X | 1 |
Iliac, Leukemia Mononuclear | | 1 |
Inguinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 7 |
Renal, Histiocytic Sarcoma | X | 1 |
Renal, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 5| 7| | |
DAY ON TEST | 9| 8| 2| | |
| 4| 2| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1.0 | 1| 1| 1| | L |
MG/M3 | 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
Leukemia Mononuclear | | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 52 |
Leukemia Mononuclear | | 12 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 47 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X | 22 |
__________________________________________________________________________|____________|
Thymus | + + + | 51 |
Leukemia Mononuclear | | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Fibroadenoma | X | 10 |
__________________________________________________________________________|____________|
Skin | + + + | 53 |
Histiocytic Sarcoma | X | 1 |
Keratoacanthoma | | 1 |
Pinna, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 51 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma | X | 5 |
Alveolar/Bronchiolar Carcinoma | | 3 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 5| 7| | |
DAY ON TEST | 9| 8| 2| | |
| 4| 2| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1.0 | 1| 1| 1| | L |
MG/M3 | 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + | 52 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X | 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 3| 6| 7| 5| 5| 5| 7| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 6| 6| 7| 2| 7|
DAY ON TEST | 6| 0| 3| 7| 9| 6| 3| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 8| 3| 5| 0|
| 1| 8| 6| 8| 4| 5| 3| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 7| 3| 6| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
| 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
Mesothelioma NOS | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + M I +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma NOS | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Mesothelioma NOS | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Mesothelioma NOS | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X |
Mesothelioma NOS | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma NOS | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma NOS | X |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Mesothelioma NOS | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 3| 6| 7| 5| 5| 5| 7| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 6| 6| 7| 2| 7|
DAY ON TEST | 6| 0| 3| 7| 9| 6| 3| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 8| 3| 5| 0|
| 1| 8| 6| 8| 4| 5| 3| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 7| 3| 6| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
| 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X X X|
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + I + + + + +|
Adenoma | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Mediastinum, Leukemia Mononuclear | X |
Thoracic, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + A + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X |
Tunic, Mesothelioma NOS | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node | + |
Axillary, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 3| 6| 7| 5| 5| 5| 7| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 6| 6| 7| 2| 7|
DAY ON TEST | 6| 0| 3| 7| 9| 6| 3| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 8| 3| 5| 0|
| 1| 8| 6| 8| 4| 5| 3| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 7| 3| 6| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
| 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + M + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + I + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + I + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + I + + + + + + + I +|
Adenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Preputial | |
Gland | |
Fibroma | X |
Keratoacanthoma | X X X |
Squamous Cell Papilloma | |
Pinna, Keratoacanthoma | |
Pinna, Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Lipoma | |
Tail, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spinal Cord | |
Astrocytoma Benign | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + I I + + + + + + + I + + + + + + + + + I + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 3| 6| 7| 5| 5| 5| 7| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 6| 6| 7| 2| 7|
DAY ON TEST | 6| 0| 3| 7| 9| 6| 3| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 8| 3| 5| 0|
| 1| 8| 6| 8| 4| 5| 3| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 7| 3| 6| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
| 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 4|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Carcinoma, Metastatic, Preputial | |
Gland | |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X|
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
Mesothelioma NOS | X |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 5| 7| 5| 5| 7| 5| 7| 5| 6| 6| 5| 7| 6| 7| 6| 7| 6| 5| 5| 7| 6| 6| 7| 5| 7|
DAY ON TEST | 5| 1| 9| 2| 1| 7| 3| 5| 3| 7| 4| 3| 7| 3| 9| 0| 3| 7| 9| 3| 3| 5| 3| 3| 3|
| 9| 5| 9| 1| 3| 4| 3| 3| 4| 8| 2| 3| 1| 7| 9| 1| 5| 2| 6| 7| 9| 1| 6| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
Mesothelioma NOS | |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + A + + + + + + + + M + + + + + I + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Mesothelioma NOS | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Mesothelioma NOS | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X X X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | |
Mesothelioma NOS | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X |
Mesothelioma NOS | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma NOS | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma NOS | |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma NOS | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 5| 7| 5| 5| 7| 5| 7| 5| 6| 6| 5| 7| 6| 7| 6| 7| 6| 5| 5| 7| 6| 6| 7| 5| 7|
DAY ON TEST | 5| 1| 9| 2| 1| 7| 3| 5| 3| 7| 4| 3| 7| 3| 9| 0| 3| 7| 9| 3| 3| 5| 3| 3| 3|
| 9| 5| 9| 1| 3| 4| 3| 3| 4| 8| 2| 3| 1| 7| 9| 1| 5| 2| 6| 7| 9| 1| 6| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Complex | X |
Pheochromocytoma Benign | X X X X X X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Mediastinum, Leukemia Mononuclear | |
Thoracic, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X X X |
Tunic, Mesothelioma NOS | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node | + + + |
Axillary, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 5| 7| 5| 5| 7| 5| 7| 5| 6| 6| 5| 7| 6| 7| 6| 7| 6| 5| 5| 7| 6| 6| 7| 5| 7|
DAY ON TEST | 5| 1| 9| 2| 1| 7| 3| 5| 3| 7| 4| 3| 7| 3| 9| 0| 3| 7| 9| 3| 3| 5| 3| 3| 3|
| 9| 5| 9| 1| 3| 4| 3| 3| 4| 8| 2| 3| 1| 7| 9| 1| 5| 2| 6| 7| 9| 1| 6| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + I + + + + + + + + + + + + M + M|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + I + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Preputial | |
Gland | X |
Fibroma | X |
Keratoacanthoma | |
Squamous Cell Papilloma | X |
Pinna, Keratoacanthoma | X |
Pinna, Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Lipoma | X |
Tail, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spinal Cord | + |
Astrocytoma Benign | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 5| 7| 5| 5| 7| 5| 7| 5| 6| 6| 5| 7| 6| 7| 6| 7| 6| 5| 5| 7| 6| 6| 7| 5| 7|
DAY ON TEST | 5| 1| 9| 2| 1| 7| 3| 5| 3| 7| 4| 3| 7| 3| 9| 0| 3| 7| 9| 3| 3| 5| 3| 3| 3|
| 9| 5| 9| 1| 3| 4| 3| 3| 4| 8| 2| 3| 1| 7| 9| 1| 5| 2| 6| 7| 9| 1| 6| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Carcinoma, Metastatic, Preputial | |
Gland | X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X |
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X |
Mesothelioma NOS | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 7| 5| | |
DAY ON TEST | 6| 2| 3| | |
| 5| 8| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0.0MG/M3 | 6| 6| 7| | L |
| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 51 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 51 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 51 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Hepatocellular Adenoma | | 4 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X | 24 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Adenoma | | 1 |
Leukemia Mononuclear | | 6 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Leukemia Mononuclear | | 1 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Leukemia Mononuclear | | 1 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | X | 9 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 7| 5| | |
DAY ON TEST | 6| 2| 3| | |
| 5| 8| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0.0MG/M3 | 6| 6| 7| | L |
| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Leukemia Mononuclear | | 6 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Leukemia Mononuclear | X | 9 |
Pheochromocytoma Complex | | 1 |
Pheochromocytoma Benign | | 12 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Adenoma | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 50 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Leukemia Mononuclear | | 6 |
Pars Distalis, Adenoma | X X | 20 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | | 4 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Mediastinum, Leukemia Mononuclear | | 1 |
Thoracic, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + | 39 |
__________________________________________________________________________|____________|
Epididymis | + + + | 53 |
__________________________________________________________________________|____________|
Penis | + + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 53 |
Adenoma | | 1 |
Carcinoma | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 52 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Testes | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 7| 5| | |
DAY ON TEST | 6| 2| 3| | |
| 5| 8| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0.0MG/M3 | 6| 6| 7| | L |
| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Bilateral, Interstitial Cell, Adenoma| | 28 |
Interstitial Cell, Adenoma | | 11 |
Tunic, Mesothelioma NOS | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Leukemia Mononuclear | | 11 |
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
Axillary, Leukemia Mononuclear | | 2 |
Iliac, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | X | 4 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 52 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 50 |
Leukemia Mononuclear | | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Leukemia Mononuclear | X | 13 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 49 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Leukemia Mononuclear | X | 28 |
__________________________________________________________________________|____________|
Thymus | + + + | 50 |
Leukemia Mononuclear | | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 49 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + | 53 |
Carcinoma, Metastatic, Preputial | | |
Gland | | 1 |
Fibroma | | 2 |
Keratoacanthoma | X | 4 |
Squamous Cell Papilloma | | 1 |
Pinna, Keratoacanthoma | | 1 |
Pinna, Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Lipoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 7| 5| | |
DAY ON TEST | 6| 2| 3| | |
| 5| 8| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0.0MG/M3 | 6| 6| 7| | L |
| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Tail, Fibroma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
Cranium, Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Astrocytoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 49 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Carcinoma, Metastatic, Preputial | | |
Gland | | 1 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X | 23 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Nose | + + + | 53 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 52 |
Leukemia Mononuclear | X | 8 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X | 28 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 6| 7| 3| 5| 5| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 3| 9| 3| 9| 3| 9| 1| 2| 3| 0| 3| 3| 0| 9| 3| 3| 9| 6| 5| 3| 2| 3| 9| 3|
| 7| 8| 5| 3| 9| 3| 0| 8| 3| 6| 0| 3| 6| 8| 9| 9| 7| 8| 3| 2| 6| 3| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + M + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X X X X X X X X X|
Bilateral, Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Adenoma | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 6| 7| 3| 5| 5| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 3| 9| 3| 9| 3| 9| 1| 2| 3| 0| 3| 3| 0| 9| 3| 3| 9| 6| 5| 3| 2| 3| 9| 3|
| 7| 8| 5| 3| 9| 3| 0| 8| 3| 6| 0| 3| 6| 8| 9| 9| 7| 8| 3| 2| 6| 3| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | + |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Thoracic, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X X |
Tunic, Mesothelioma NOS | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Axillary, Leukemia Mononuclear | X X X |
Deep Cervical, Leukemia Mononuclear | X X |
Iliac, Leukemia Mononuclear | X X X X |
Pancreatic, Leukemia Mononuclear | X X X X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X |
Mesothelioma NOS, Metastatic | |
__________________________________________________________________________|
Thymus | M + M + + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 6| 7| 3| 5| 5| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 3| 9| 3| 9| 3| 9| 1| 2| 3| 0| 3| 3| 0| 9| 3| 3| 9| 6| 5| 3| 2| 3| 9| 3|
| 7| 8| 5| 3| 9| 3| 0| 8| 3| 6| 0| 3| 6| 8| 9| 9| 7| 8| 3| 2| 6| 3| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + I + + + M + + +|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Fibroma | X |
Keratoacanthoma | |
Tail, Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Oligodendroglioma NOS | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X X |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X |
Mesothelioma NOS | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 6| 7| 7| 7| 6| 6| 4| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 4| 9| 6| 3| 2| 3| 3| 3| 5| 3| 5| 0| 3| 3| 3| 3| 3| 4| 1| 6| 3| 3| 1| 3| 9|
| 9| 5| 9| 8| 4| 6| 6| 6| 0| 9| 5| 1| 3| 3| 6| 8| 7| 2| 3| 1| 6| 3| 7| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.15 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/M3 | 0| 2| 3| 4| 7| 9| 0| 1| 4| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + M + + + + M + + + M|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X X X X X |
Bilateral, Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pars Distalis, Adenoma | X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 6| 7| 7| 7| 6| 6| 4| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 4| 9| 6| 3| 2| 3| 3| 3| 5| 3| 5| 0| 3| 3| 3| 3| 3| 4| 1| 6| 3| 3| 1| 3| 9|
| 9| 5| 9| 8| 4| 6| 6| 6| 0| 9| 5| 1| 3| 3| 6| 8| 7| 2| 3| 1| 6| 3| 7| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.15 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/M3 | 0| 2| 3| 4| 7| 9| 0| 1| 4| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Thoracic, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X X X |
Tunic, Mesothelioma NOS | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Axillary, Leukemia Mononuclear | X |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X|
Pancreatic, Leukemia Mononuclear | X X X X X|
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + + + + + + + + + + + + + M + M +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
Mesothelioma NOS, Metastatic | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 6| 7| 7| 7| 6| 6| 4| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 4| 9| 6| 3| 2| 3| 3| 3| 5| 3| 5| 0| 3| 3| 3| 3| 3| 4| 1| 6| 3| 3| 1| 3| 9|
| 9| 5| 9| 8| 4| 6| 6| 6| 0| 9| 5| 1| 3| 3| 6| 8| 7| 2| 3| 1| 6| 3| 7| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.15 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/M3 | 0| 2| 3| 4| 7| 9| 0| 1| 4| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + M + + + + + + + + + + + + + + + + +|
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X |
Fibroma | X |
Keratoacanthoma | X X X X |
Tail, Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Oligodendroglioma NOS | X|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
Mesothelioma NOS | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 7| 3| 3| | |
| 0| 3| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.15 | 0| 0| 1| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 51 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Hepatocellular Adenoma | X | 1 |
Leukemia Mononuclear | | 27 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Adenoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 52 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | | 7 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 52 |
Leukemia Mononuclear | | 13 |
Pheochromocytoma Malignant | | 2 |
Pheochromocytoma Benign | X | 23 |
Bilateral, Pheochromocytoma Benign | | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Adenoma | | 4 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + | 50 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 7| 3| 3| | |
| 0| 3| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.15 | 0| 0| 1| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | X X | 17 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
C-Cell, Adenoma | | 2 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Thoracic, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + | 47 |
__________________________________________________________________________|____________|
Epididymis | + + + | 53 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 53 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Prostate | + + + | 53 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 53 |
__________________________________________________________________________|____________|
Testes | + + + | 53 |
Bilateral, Interstitial Cell, Adenoma| X | 30 |
Interstitial Cell, Adenoma | | 15 |
Tunic, Mesothelioma NOS | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + M + | 52 |
Leukemia Mononuclear | | 15 |
__________________________________________________________________________|____________|
Lymph Node | | 16 |
Axillary, Leukemia Mononuclear | | 4 |
Deep Cervical, Leukemia Mononuclear | | 2 |
Iliac, Leukemia Mononuclear | | 5 |
Pancreatic, Leukemia Mononuclear | | 10 |
Renal, Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 51 |
Leukemia Mononuclear | | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + | 51 |
Leukemia Mononuclear | | 13 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Leukemia Mononuclear | | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 7| 3| 3| | |
| 0| 3| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.15 | 0| 0| 1| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + | 49 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Leukemia Mononuclear | | 19 |
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Leukemia Mononuclear | | 32 |
Mesothelioma NOS, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + | 49 |
Leukemia Mononuclear | | 15 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M | 48 |
Fibroadenoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + | 53 |
Basal Cell Carcinoma | | 1 |
Fibroma | | 2 |
Keratoacanthoma | | 4 |
Tail, Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + M + | 52 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Leukemia Mononuclear | | 2 |
Oligodendroglioma NOS | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 53 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma | | 3 |
Alveolar/Bronchiolar Carcinoma | | 3 |
Leukemia Mononuclear | | 23 |
__________________________________________________________________________|____________|
Nose | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 7| 3| 3| | |
| 0| 3| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.15 | 0| 0| 1| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | | 32 |
Mesothelioma NOS | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 6| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 9| 4| 4| 1| 9| 5| 3| 3| 0| 2| 7| 0| 3| 5| 2| 3| 6| 2| 3| 3| 3| 0| 3| 2| 3|
| 0| 3| 8| 1| 4| 2| 6| 3| 3| 3| 8| 3| 6| 9| 7| 6| 3| 3| 3| 3| 3| 9| 3| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
MG/M3 | 2| 3| 4| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Testes | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X X X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Pharynx | + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Gingiva, Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
Pheochromocytoma Malignant | X X X X |
Pheochromocytoma Benign | X X X X X X X|
Bilateral, Pheochromocytoma Malignant| X X X X |
Bilateral, Pheochromocytoma Benign | X X X X X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 6| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 9| 4| 4| 1| 9| 5| 3| 3| 0| 2| 7| 0| 3| 5| 2| 3| 6| 2| 3| 3| 3| 0| 3| 2| 3|
| 0| 3| 8| 1| 4| 2| 6| 3| 3| 3| 8| 3| 6| 9| 7| 6| 3| 3| 3| 3| 3| 9| 3| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
MG/M3 | 2| 3| 4| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Abdominal, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X|
Tunic, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + |
Axillary, Leukemia Mononuclear | X |
Iliac, Fibrosarcoma, Metastatic, | |
Testes | |
Iliac, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + + + + + + + + + + + + + + + I + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 6| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 9| 4| 4| 1| 9| 5| 3| 3| 0| 2| 7| 0| 3| 5| 2| 3| 6| 2| 3| 3| 3| 0| 3| 2| 3|
| 0| 3| 8| 1| 4| 2| 6| 3| 3| 3| 8| 3| 6| 9| 7| 6| 3| 3| 3| 3| 3| 9| 3| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
MG/M3 | 2| 3| 4| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + I + + M + + + + + + + M + M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Fibroma | X X |
Keratoacanthoma | X |
Nose, Squamous Cell Papilloma | X |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X X |
Chordoma, Metastatic, Tissue NOS | X |
Fibrosarcoma, Metastatic, Testes | |
Leukemia Mononuclear | X X X X X X X X X X X X |
Osteosarcoma, Metastatic, Bone | X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 4| 6| 5| 7| 7| 6| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 5| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 7| 3| 3| 5| 7| 2| 4| 6| 3| 3| 1| 0| 3| 3| 3| 9| 6| 3| 6| 3| 2| 3| 0|
| 4| 1| 8| 6| 3| 0| 7| 1| 2| 3| 7| 3| 6| 7| 7| 6| 7| 5| 4| 6| 0| 1| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MG/M3 | 4| 5| 6| 7| 8| 0| 1| 3| 5| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Testes | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Pharynx | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Gingiva, Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X X X X X X |
Bilateral, Pheochromocytoma Malignant| X |
Bilateral, Pheochromocytoma Benign | X X X X X X X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 4| 6| 5| 7| 7| 6| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 5| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 7| 3| 3| 5| 7| 2| 4| 6| 3| 3| 1| 0| 3| 3| 3| 9| 6| 3| 6| 3| 2| 3| 0|
| 4| 1| 8| 6| 3| 0| 7| 1| 2| 3| 7| 3| 6| 7| 7| 6| 7| 5| 4| 6| 0| 1| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MG/M3 | 4| 5| 6| 7| 8| 0| 1| 3| 5| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abdominal, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X |
Tunic, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Lymph Node | + + +|
Axillary, Leukemia Mononuclear | |
Iliac, Fibrosarcoma, Metastatic, | |
Testes | X |
Iliac, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + M + M + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
_____________________________________________________________________________________________________________________
| 4| 6| 5| 7| 7| 6| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 5| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 7| 3| 3| 5| 7| 2| 4| 6| 3| 3| 1| 0| 3| 3| 3| 9| 6| 3| 6| 3| 2| 3| 0|
| 4| 1| 8| 6| 3| 0| 7| 1| 2| 3| 7| 3| 6| 7| 7| 6| 7| 5| 4| 6| 0| 1| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MG/M3 | 4| 5| 6| 7| 8| 0| 1| 3| 5| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M M + + M + + M + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
Fibroma | X |
Keratoacanthoma | |
Nose, Squamous Cell Papilloma | |
Subcutaneous Tissue, Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + I|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X X X X |
Chordoma, Metastatic, Tissue NOS | |
Fibrosarcoma, Metastatic, Testes | X |
Leukemia Mononuclear | X X X X X X X X X X X|
Osteosarcoma, Metastatic, Bone | |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 7| 5| | |
DAY ON TEST | 8| 0| 6| | |
| 4| 3| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.0 | 4| 4| 5| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M | 52 |
Fibrosarcoma, Metastatic, Testes | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + | 52 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Hepatocellular Adenoma | | 3 |
Leukemia Mononuclear | | 30 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Gingiva, Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Leukemia Mononuclear | | 18 |
Pheochromocytoma Malignant | | 6 |
Pheochromocytoma Benign | | 14 |
Bilateral, Pheochromocytoma Malignant| | 5 |
Bilateral, Pheochromocytoma Benign | X | 23 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Adenoma | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 7| 5| | |
DAY ON TEST | 8| 0| 6| | |
| 4| 3| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.0 | 4| 4| 5| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Leukemia Mononuclear | | 4 |
Pars Distalis, Adenoma | X X | 17 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
C-Cell, Adenoma | X | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Abdominal, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + | 48 |
__________________________________________________________________________|____________|
Epididymis | + + + | 53 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 53 |
__________________________________________________________________________|____________|
Prostate | + + + | 53 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 52 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Testes | + + + | 53 |
Leukemia Mononuclear | | 2 |
Bilateral, Interstitial Cell, Adenoma| X | 15 |
Interstitial Cell, Adenoma | | 20 |
Tunic, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Leukemia Mononuclear | | 16 |
__________________________________________________________________________|____________|
Lymph Node | | 6 |
Axillary, Leukemia Mononuclear | | 1 |
Iliac, Fibrosarcoma, Metastatic, | | |
Testes | | 1 |
Iliac, Leukemia Mononuclear | | 2 |
Pancreatic, Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 53 |
Leukemia Mononuclear | | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 50 |
Leukemia Mononuclear | | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 7| 5| | |
DAY ON TEST | 8| 0| 6| | |
| 4| 3| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.0 | 4| 4| 5| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Leukemia Mononuclear | | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 50 |
Leukemia Mononuclear | | 17 |
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Leukemia Mononuclear | | 35 |
__________________________________________________________________________|____________|
Thymus | + + M | 49 |
Leukemia Mononuclear | | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 43 |
__________________________________________________________________________|____________|
Skin | + + + | 53 |
Basal Cell Adenoma | | 1 |
Fibroma | | 3 |
Keratoacanthoma | | 1 |
Nose, Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
Maxilla, Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Astrocytoma NOS | | 1 |
Leukemia Mononuclear | | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 52 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma | | 5 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | | 7 |
Chordoma, Metastatic, Tissue NOS | | 1 |
Fibrosarcoma, Metastatic, Testes | | 1 |
Leukemia Mononuclear | | 23 |
Osteosarcoma, Metastatic, Bone | | 1 |
Pheochromocytoma Malignant, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
NTP Experiment-Test: 05107-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:46:15
__________________________________________________________________________________________________________________________________
| 5| 7| 5| | |
DAY ON TEST | 8| 0| 6| | |
| 4| 3| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.0 | 4| 4| 5| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Metastatic, Adrenal Medulla | | 1 |
__________________________________________________________________________|____________|
Nose | + + + | 52 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | | 35 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
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---------- END OF REPORT ----------
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