TDMS Study 05107-06 Pathology Tables
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
Core Animals
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 12035722
Lock Date: 10/14/92
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25026 Other 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6| 6|
DAY ON TEST | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| 3| 9| 7|
| 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 4| 3| 6| 9| 3| 4| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 2| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + A + + + +|
Polyp Adenomatous | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphoma Malignant | X X|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X X X X X X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma, Metastatic, | |
Uterus | X |
Lymphoma Malignant | X|
__________________________________________________________________________|
Mesentery | + |
Carcinoma, Metastatic, Islets, | |
Pancreatic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Liver | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Lymphoma Malignant | X|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6| 6|
DAY ON TEST | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| 3| 9| 7|
| 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 4| 3| 6| 9| 3| 4| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 2| 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + M + + + M +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
Histiocytic Sarcoma, Metastatic, | |
Uterus | X |
Lymphoma Malignant | X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Histiocytic Sarcoma | X X |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Uterus | X |
Lymphoma Malignant | X|
__________________________________________________________________________|
Lymph Node | + + + +|
Axillary, Lymphoma Malignant | X|
Iliac, Hemangiosarcoma | X |
Iliac, Lymphoma Malignant | X|
Inguinal, Lymphoma Malignant | X|
Pancreatic, Lymphoma Malignant | X|
Renal, Histiocytic Sarcoma, | |
Metastatic, Uterus | X |
Renal, Lymphoma Malignant | X|
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + + + + + + + + + + + I + +|
Histiocytic Sarcoma, Metastatic, | |
Uterus | X |
Lymphoma Malignant | X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Uterus | X |
Lymphoma Malignant | X X|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6| 6|
DAY ON TEST | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| 3| 9| 7|
| 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 4| 3| 6| 9| 3| 4| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 2| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M + M + M M M M I M M + M M + + I + + M M + +|
Histiocytic Sarcoma, Metastatic, | |
Uterus | X |
Lymphoma Malignant | X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | |
Histiocytic Sarcoma, Metastatic, | |
Uterus | X |
Lymphoma Malignant | X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pinna, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + I + + M + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X X X |
Hepatocellular Carcinoma, Metastatic | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Lymphoma Malignant | X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6| 6|
DAY ON TEST | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| 3| 9| 7|
| 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 4| 3| 6| 9| 3| 4| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 2| 4|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Histiocytic Sarcoma, Metastatic, | |
Uterus | X |
Lymphoma Malignant | X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + I + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X X|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3| 6|
| 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + A A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + M + + + + + + + + A + + M + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A A + + + + + + A + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A A + + + + + + A + + +|
Polyp Adenomatous | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A A + + + + + + A + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A A + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant | |
__________________________________________________________________________|
Mesentery | + |
Carcinoma, Metastatic, Islets, | |
Pancreatic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Liver | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + M + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3| 6|
| 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X X |
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Histiocytic Sarcoma | |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + M + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node | + + + |
Axillary, Lymphoma Malignant | |
Iliac, Hemangiosarcoma | |
Iliac, Lymphoma Malignant | |
Inguinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | X |
Renal, Histiocytic Sarcoma, | |
Metastatic, Uterus | |
Renal, Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + I I + + + + M + + + + + I + + + + + I + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + M + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3| 6|
| 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | I M M M M M M + M M M + + M M M + + M M + M M M M|
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | X |
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pinna, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + I + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatocellular Carcinoma, Metastatic | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3| 6|
| 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 3| 7| 7| 7| | |
DAY ON TEST | 3| 3| 0| 3| 8| 3| 3| 3| | |
| 3| 3| 0| 3| 5| 6| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Gallbladder | + + + I + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M M + M + + M + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 54 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 53 |
Polyp Adenomatous | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 54 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 58 |
Hemangiosarcoma | | 2 |
Hepatocellular Carcinoma | | 11 |
Hepatocellular Adenoma | X X | 9 |
Hepatocellular Adenoma, Multiple | | 4 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | | 1 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Carcinoma, Metastatic, Islets, | | |
Pancreatic | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 58 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 57 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 58 |
Hemangiosarcoma, Metastatic, Liver | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 58 |
Adenoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 3| 7| 7| 7| | |
DAY ON TEST | 3| 3| 0| 3| 8| 3| 3| 3| | |
| 3| 3| 0| 3| 5| 6| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 58 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M | 52 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 58 |
Pars Distalis, Adenoma | | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 58 |
Follicular Cell, Adenoma | | 2 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 58 |
Cystadenoma | | 2 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 58 |
Hemangioma | | 1 |
Histiocytic Sarcoma | | 2 |
Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 57 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + | 9 |
Axillary, Lymphoma Malignant | | 1 |
Iliac, Hemangiosarcoma | | 1 |
Iliac, Lymphoma Malignant | X | 2 |
Inguinal, Lymphoma Malignant | | 1 |
Pancreatic, Lymphoma Malignant | | 2 |
Renal, Histiocytic Sarcoma, | | |
Metastatic, Uterus | | 1 |
Renal, Lymphoma Malignant | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 3| 7| 7| 7| | |
DAY ON TEST | 3| 3| 0| 3| 8| 3| 3| 3| | |
| 3| 3| 0| 3| 5| 6| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + I + + + + + | 50 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 57 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 55 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | | 1 |
Lymphoma Malignant | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M M M | 15 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 58 |
Fibrosarcoma | | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | | 1 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 58 |
Lymphoma Malignant | X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 57 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 58 |
Pinna, Fibrosarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 3| 7| 7| 7| | |
DAY ON TEST | 3| 3| 0| 3| 8| 3| 3| 3| | |
| 3| 3| 0| 3| 5| 6| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + M | 54 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 58 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | | 1 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Carcinoma | X X | 7 |
Hepatocellular Carcinoma, Metastatic | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 2 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 58 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 58 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|
| 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + A + + + M + + + + + + + + + + A + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + A + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Large, Rectum | M + M M + + + M + + + M + + + M + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + A + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + A + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + A + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
Sarcoma, Metastatic, Skeletal Muscle | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Mesentery | + + + |
Lymphoma Malignant | |
Sarcoma, Metastatic, Skeletal Muscle | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
Sarcoma, Metastatic, Skeletal Muscle | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|
| 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Metastatic, Lung | X |
Sarcoma, Metastatic, Skeletal Muscle | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Sarcoma, Metastatic, Skeletal Muscle | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Adrenal Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
Histiocytic Sarcoma | X |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Mediastinum, Hemangiosarcoma | |
Thoracic, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Luteoma | X |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Skeletal Muscle | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
Teratoma Benign | |
Teratoma Malignant | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|
| 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Tissue | |
NOS | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node | + + + + + |
Axillary, Lymphoma Malignant | X |
Iliac, Lymphoma Malignant | X X |
Inguinal, Lymphoma Malignant | X |
Lumbar, Lymphoma Malignant | X |
Pancreatic, Histiocytic Sarcoma | X |
Pancreatic, Lymphoma Malignant | X |
Pancreatic, Squamous Cell Carcinoma, | |
Metastatic, Stomach, Forestomach| X |
Popliteal, Lymphoma Malignant | X |
Renal, Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + A + + + + + + + + M + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + + M + + M + I + M M M + M + M I + + + + I +|
Lymphoma Malignant | X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Metastatic, Tissue | |
NOS | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
Teratoma Malignant, Metastatic, Ovary| |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|
| 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X|
Lymphoma Malignant | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Hemangiosarcoma | X |
Hemangiosarcoma, Metastatic, Spleen | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + M + I + + + + + + + + + + + +|
Lymphoma Malignant | |
Epithelium, Squamous Cell Carcinoma | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic, | |
Metastatic | X |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Skeletal Muscle | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|
| 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant | X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
Teratoma Malignant, Metastatic, Ovary| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|
| 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
0.6MG/M3 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + A + + + + + + + + A + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + A + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + A + + + + + + + + A + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X |
Sarcoma, Metastatic, Skeletal Muscle | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Mesentery | + |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Skeletal Muscle | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + A + + + +|
Lymphoma Malignant | X X X |
Sarcoma, Metastatic, Skeletal Muscle | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|
| 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
0.6MG/M3 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Metastatic, Lung | |
Sarcoma, Metastatic, Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
Sarcoma, Metastatic, Skeletal Muscle | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + A + + + +|
Adenoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + M + + + I|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Histiocytic Sarcoma | |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinum, Hemangiosarcoma | |
Thoracic, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +|
Luteoma | |
Lymphoma Malignant | X X X |
Sarcoma, Metastatic, Skeletal Muscle | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
Teratoma Benign | X|
Teratoma Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|
| 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
0.6MG/M3 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Tissue | |
NOS | |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Axillary, Lymphoma Malignant | X X X |
Iliac, Lymphoma Malignant | X X X |
Inguinal, Lymphoma Malignant | X X |
Lumbar, Lymphoma Malignant | |
Pancreatic, Histiocytic Sarcoma | |
Pancreatic, Lymphoma Malignant | X X X X |
Pancreatic, Squamous Cell Carcinoma, | |
Metastatic, Stomach, Forestomach| |
Popliteal, Lymphoma Malignant | |
Renal, Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + M M|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + A + + + +|
Hemangiosarcoma, Metastatic, Spleen | X |
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + M + + + M M + M + + I M M M + + I M M M + M|
Lymphoma Malignant | X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hemangiosarcoma, Metastatic, Tissue | |
NOS | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
Teratoma Malignant, Metastatic, Ovary| X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + A + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|
| 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
0.6MG/M3 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Hemangiosarcoma | |
Hemangiosarcoma, Metastatic, Spleen | X |
Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + I + + + + + + + + + + + + + + + + + I + + +|
Lymphoma Malignant | X |
Epithelium, Squamous Cell Carcinoma | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + A + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic, | |
Metastatic | |
Lymphoma Malignant | X X |
Sarcoma, Metastatic, Skeletal Muscle | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + M + + A + + M +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|
| 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
0.6MG/M3 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant | X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
Teratoma Malignant, Metastatic, Ovary| X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + A + + + + + + + + A + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 1| 7| 7| | |
DAY ON TEST | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3| | |
| 4| 0| 3| 7| 3| 3| 3| 2| 6| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.6MG/M3 | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + A + + | 51 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + | 55 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + + + A + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + A + + | 52 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X | 8 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | | 8 |
Hepatocellular Adenoma, Multiple | | 2 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | | 5 |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 4 |
Lymphoma Malignant | | 1 |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + M + + + A + + | 56 |
Lymphoma Malignant | | 5 |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + + | 58 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 1| 7| 7| | |
DAY ON TEST | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3| | |
| 4| 0| 3| 7| 3| 3| 3| 2| 6| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.6MG/M3 | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Lymphoma Malignant | | 2 |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + M + + + A + + | 56 |
Adenoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
Pars Distalis, Adenoma | X X | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Adenoma | | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 4 |
Histiocytic Sarcoma | | 1 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Mediastinum, Hemangiosarcoma | X | 1 |
Thoracic, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + A + + | 58 |
Luteoma | | 1 |
Lymphoma Malignant | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 1| 7| 7| | |
DAY ON TEST | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3| | |
| 4| 0| 3| 7| 3| 3| 3| 2| 6| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.6MG/M3 | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
Teratoma Benign | | 1 |
Teratoma Malignant | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hemangiosarcoma, Metastatic, Tissue | | |
NOS | X | 1 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Lymph Node | + | 12 |
Axillary, Lymphoma Malignant | | 4 |
Iliac, Lymphoma Malignant | | 5 |
Inguinal, Lymphoma Malignant | | 3 |
Lumbar, Lymphoma Malignant | | 1 |
Pancreatic, Histiocytic Sarcoma | | 1 |
Pancreatic, Lymphoma Malignant | | 5 |
Pancreatic, Squamous Cell Carcinoma, | | |
Metastatic, Stomach, Forestomach| | 1 |
Popliteal, Lymphoma Malignant | | 1 |
Renal, Lymphoma Malignant | | 6 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M + + | 57 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 5 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Lymphoma Malignant | | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + A + + | 54 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
Lymphoma Malignant | | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M M + + + M I + | 28 |
Lymphoma Malignant | | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 1| 7| 7| | |
DAY ON TEST | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3| | |
| 4| 0| 3| 7| 3| 3| 3| 2| 6| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.6MG/M3 | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 1 |
Hemangiosarcoma, Metastatic, Tissue | | |
NOS | X | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 6 |
Teratoma Malignant, Metastatic, Ovary| | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + A + + | 57 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + M + + | 59 |
Adenocarcinoma | | 3 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Keratoacanthoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Hemangiosarcoma | | 1 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + I + + + + + | 55 |
Lymphoma Malignant | | 1 |
Epithelium, Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Alveolar/Bronchiolar Adenoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 1| 7| 7| | |
DAY ON TEST | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3| | |
| 4| 0| 3| 7| 3| 3| 3| 2| 6| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.6MG/M3 | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Carcinoma | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 6 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic, | | |
Metastatic | | 1 |
Lymphoma Malignant | | 3 |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + A + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Lymphoma Malignant | | 6 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
Teratoma Malignant, Metastatic, Ovary| | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A + + | 55 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|
| 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + M A + + A + A + + A + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + A A + + + + A + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + M + + + + + + + + + + M M M + M M M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + A A + + + + A + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A A + A A + A + + A + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A A + A A + A + + A + A + + + + + + +|
Adenoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + A A + A + + A + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Mesentery | + |
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Oral Mucosa | |
Buccal, Squamous Cell Papilloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + A + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Sarcoma, Metastatic, Skeletal Muscle | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + I + + + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|
| 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M M + + + + A M + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Histiocytic Sarcoma | X |
Polyp Stromal | |
Endometrium, Adenocarcinoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + A + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node | + + + + +|
Iliac, Lymphoma Malignant | X X |
Iliac, Sarcoma, Metastatic, Skeletal | |
Muscle | X |
Pancreatic, Lymphoma Malignant | |
Pancreatic, Sarcoma, Metastatic, | |
Skeletal Muscle | X |
Renal, Lymphoma Malignant | X X |
Renal, Sarcoma, Metastatic, Skeletal | |
Muscle | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + A + + + + + + + + + M + + + + + + +|
Lymphoma Malignant | X X |
Sarcoma, Metastatic, Skeletal Muscle | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M + I M M + + M + + + + M + M + I M + M M M +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|
| 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + M + + + M + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Fibrosarcoma | |
Lymphoma Malignant | X |
Pinna, Fibrosarcoma | |
Pinna, Squamous Cell Carcinoma | X |
Sebaceous Gland, Squamous Cell | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | I I + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
__________________________________________________________________________|
Trachea | + + + + + + + M + + + + + + + M + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|
| 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant | X |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|
| 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Mesentery | |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Oral Mucosa | |
Buccal, Squamous Cell Papilloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Sarcoma, Metastatic, Skeletal Muscle | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|
| 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + M + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
Histiocytic Sarcoma | |
Polyp Stromal | X |
Endometrium, Adenocarcinoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Lymphoma Malignant | X |
Iliac, Sarcoma, Metastatic, Skeletal | |
Muscle | |
Pancreatic, Lymphoma Malignant | X X X |
Pancreatic, Sarcoma, Metastatic, | |
Skeletal Muscle | |
Renal, Lymphoma Malignant | X |
Renal, Sarcoma, Metastatic, Skeletal | |
Muscle | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Sarcoma, Metastatic, Skeletal Muscle | |
__________________________________________________________________________|
Lymph Node, Mediastinal | I M M I + + M I + + + + M M M M + M + M + M + M +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|
| 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + M + + +|
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Fibrosarcoma | X |
Lymphoma Malignant | |
Pinna, Fibrosarcoma | |
Pinna, Squamous Cell Carcinoma | |
Sebaceous Gland, Squamous Cell | |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + I + + + + + M + + + I + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|
| 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant | X |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 8| | |
| 3| 5| 3| 3| 2| 5| 3| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.2MG/M3 | 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 8| 0| 1| 3| 5| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + M + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 51 |
Adenoma | X | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 58 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X | 4 |
Hepatocellular Adenoma | X X | 9 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 5 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Buccal, Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 57 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 56 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 58 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 58 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 8| | |
| 3| 5| 3| 3| 2| 5| 3| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.2MG/M3 | 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 8| 0| 1| 3| 5| 8| 9| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 58 |
Pars Distalis, Adenoma | | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 58 |
Follicular Cell, Adenoma | | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 58 |
Cystadenoma | X | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 58 |
Fibroma | | 1 |
Histiocytic Sarcoma | | 1 |
Polyp Stromal | | 1 |
Endometrium, Adenocarcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 57 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + | 11 |
Iliac, Lymphoma Malignant | | 3 |
Iliac, Sarcoma, Metastatic, Skeletal | | |
Muscle | | 1 |
Pancreatic, Lymphoma Malignant | | 3 |
Pancreatic, Sarcoma, Metastatic, | | |
Skeletal Muscle | | 1 |
Renal, Lymphoma Malignant | | 3 |
Renal, Sarcoma, Metastatic, Skeletal | | |
Muscle | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + | 58 |
Lymphoma Malignant | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 8| | |
| 3| 5| 3| 3| 2| 5| 3| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.2MG/M3 | 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 8| 0| 1| 3| 5| 8| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 55 |
Lymphoma Malignant | | 3 |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + M | 29 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 58 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 53 |
Lymphoma Malignant | | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 58 |
Fibroma | X | 1 |
Fibrosarcoma | | 1 |
Lymphoma Malignant | | 1 |
Pinna, Fibrosarcoma | X | 1 |
Pinna, Squamous Cell Carcinoma | | 1 |
Sebaceous Gland, Squamous Cell | | |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 57 |
Hemangiosarcoma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + I + + + + I + | 51 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 58 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 8| | |
| 3| 5| 3| 3| 2| 5| 3| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.2MG/M3 | 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 8| 0| 1| 3| 5| 8| 9| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 58 |
Hemangioma | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 56 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 58 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 57 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 58 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 0| 4| | |
DAY ON TEST | 7| 4| | |
| 4| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| | T |
ANIMAL ID | 4| 4| | A |
1.2MG/M3 | 2| 7| | L |
LUNG TOX | 6| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + | 2 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + | 1 |
__________________________________________________________________________|____________|
Ovary | + + | 2 |
__________________________________________________________________________|____________|
Uterus | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | I + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 0| 4| | |
DAY ON TEST | 7| 4| | |
| 4| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| | T |
ANIMAL ID | 4| 4| | A |
1.2MG/M3 | 2| 7| | L |
LUNG TOX | 6| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + | 1 |
__________________________________________________________________________|____________|
Spleen | + + | 2 |
__________________________________________________________________________|____________|
Thymus | + M | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 2 |
__________________________________________________________________________|____________|
Lung | + + | 2 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + | 2 |
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + | 2 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 5| 5| 5| 5| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7| 7|
DAY ON TEST | 4| 8| 8| 4| 6| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3| 3|
| 0| 4| 6| 4| 1| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 1| 2| 3| 4| 5| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + A A + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Liver | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + M + + M + + + + + + M + M + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A A + + + + +|
Adenoma | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X |
Hepatocholangiocarcinoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Mesentery | |
Fibrous Histiocytoma, Metastatic, | |
Liver | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Liver | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Liver | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Liver | |
Capsule, Adenoma | X X |
__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Liver | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 5| 5| 5| 5| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7| 7|
DAY ON TEST | 4| 8| 8| 4| 6| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3| 3|
| 0| 4| 6| 4| 1| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 1| 2| 3| 4| 5| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Complex | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + M + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + I + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Thoracic, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Fibrous Histiocytoma, Metastatic, | |
Liver | |
__________________________________________________________________________|
Penis | + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Liver | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Axillary, Fibrosarcoma, Metastatic, | |
Skin | X |
Pancreatic, Fibrous Histiocytoma, | |
Metastatic, Liver | |
Pancreatic, Lymphoma Malignant | |
Renal, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M + + M + + + + + + + M + + + M + + M + + M +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hemangioma | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 5| 5| 5| 5| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7| 7|
DAY ON TEST | 4| 8| 8| 4| 6| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3| 3|
| 0| 4| 6| 4| 1| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 1| 2| 3| 4| 5| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M M M + + M M + M + M M + M M M M + M M M M|
Lymphoma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Thymus | + M + + + + + M + + + + + + + + + + + + + + M + M|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, Two | |
Alveolar/Bronchiolar Carcinoma | X X X |
Fibrous Histiocytoma, Metastatic, | |
Liver | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Pheochromocytoma Complex, Metastatic,| |
Adrenal Medulla | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Liver | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 5| 5| 5| 5| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7| 7|
DAY ON TEST | 4| 8| 8| 4| 6| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3| 3|
| 0| 4| 6| 4| 1| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 1| 2| 3| 4| 5| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Pelvis, Hemangiosarcoma | X |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 3|
DAY ON TEST | 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4| 1|
| 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + I + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + A + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Liver | X |
__________________________________________________________________________|
Intestine Large, Colon | + + M + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M M + + + + M + + + + + + M + M M M + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X |
Hepatocholangiocarcinoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Mesentery | + |
Fibrous Histiocytoma, Metastatic, | |
Liver | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Liver | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Liver | X |
__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Liver | X |
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Liver | X |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 3|
DAY ON TEST | 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4| 1|
| 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Complex | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + I + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Thoracic, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
Fibrous Histiocytoma, Metastatic, | |
Liver | X |
__________________________________________________________________________|
Penis | + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Liver | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
Axillary, Fibrosarcoma, Metastatic, | |
Skin | |
Pancreatic, Fibrous Histiocytoma, | |
Metastatic, Liver | X |
Pancreatic, Lymphoma Malignant | |
Renal, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + I M + M + + + M M + + M I I + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + M + M + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + M + + + + + + + + + + + + + + + + +|
Hemangioma | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 3|
DAY ON TEST | 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4| 1|
| 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | I M M + M M + M M M M M M I + M M M M M M M M M M|
Lymphoma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Thymus | + + + I M + M M M M + M + + M + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + I + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Adenoma, Two | X |
Alveolar/Bronchiolar Carcinoma | X X X X |
Fibrous Histiocytoma, Metastatic, | |
Liver | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Pheochromocytoma Complex, Metastatic,| |
Adrenal Medulla | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Liver | X |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 3|
DAY ON TEST | 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4| 1|
| 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7| 9|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Pelvis, Hemangiosarcoma | |
__________________________________________________________________________|
Ureter | +|
__________________________________________________________________________|
Urethra | + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 5| 7| 7| 6| | |
DAY ON TEST | 4| 3| 6| 3| 8| 8| 4| 4| 3| | |
| 0| 7| 3| 7| 8| 5| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 0| 1| 3| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + | 56 |
Fibrous Histiocytoma, Metastatic, | | |
Liver | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + M M + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 56 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 59 |
Fibrous Histiocytoma | | 1 |
Hepatocellular Carcinoma | X X X | 10 |
Hepatocellular Adenoma | X | 11 |
Hepatocellular Adenoma, Multiple | | 2 |
Hepatocholangiocarcinoma | | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Liver | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 59 |
Fibrous Histiocytoma, Metastatic, | | |
Liver | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 59 |
Fibrous Histiocytoma, Metastatic, | | |
Liver | | 1 |
__________________________________________________________________________|____________|
Tooth | | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 59 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + | 59 |
Fibrous Histiocytoma, Metastatic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 5| 7| 7| 6| | |
DAY ON TEST | 4| 3| 6| 3| 8| 8| 4| 4| 3| | |
| 0| 7| 3| 7| 8| 5| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 0| 1| 3| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Liver | | 1 |
Capsule, Adenoma | | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + | 58 |
Fibrous Histiocytoma, Metastatic, | | |
Liver | | 1 |
Pheochromocytoma Complex | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 59 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + | 56 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 59 |
Follicular Cell, Adenoma | | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Thoracic, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 59 |
Fibrous Histiocytoma | | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Liver | | 1 |
__________________________________________________________________________|____________|
Penis | | 12 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + | 59 |
Fibrous Histiocytoma, Metastatic, | | |
Liver | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 59 |
Interstitial Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + | 18 |
Axillary, Fibrosarcoma, Metastatic, | | |
Skin | | 1 |
Pancreatic, Fibrous Histiocytoma, | | |
Metastatic, Liver | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 5| 7| 7| 6| | |
DAY ON TEST | 4| 3| 6| 3| 8| 8| 4| 4| 3| | |
| 0| 7| 3| 7| 8| 5| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 0| 1| 3| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Lymphoma Malignant | X | 1 |
Renal, Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + M I + M + | 39 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + M + M + M | 51 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 56 |
Hemangioma | | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M + + M | 12 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 59 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M | 46 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 59 |
Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + M + + | 57 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 59 |
Alveolar/Bronchiolar Adenoma | X X | 5 |
Alveolar/Bronchiolar Adenoma, Two | | 1 |
Alveolar/Bronchiolar Carcinoma | | 7 |
Fibrous Histiocytoma, Metastatic, | | |
Liver | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 5| 7| 7| 6| | |
DAY ON TEST | 4| 3| 6| 3| 8| 8| 4| 4| 3| | |
| 0| 7| 3| 7| 8| 5| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 0| 1| 3| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Pheochromocytoma Complex, Metastatic,| | |
Adrenal Medulla | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 59 |
Fibrous Histiocytoma, Metastatic, | | |
Liver | | 1 |
Pelvis, Hemangiosarcoma | | 1 |
__________________________________________________________________________|____________|
Ureter | | 2 |
__________________________________________________________________________|____________|
Urethra | + | 6 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 59 |
Leiomyosarcoma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 59 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 0| 4| | |
DAY ON TEST | 6| 3| | |
| 7| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| | T |
ANIMAL ID | 0| 0| | A |
0.0MG/M3 | 4| 6| | L |
LUNG TOX | 2| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + A | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A A | |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A A | |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A | |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A | |
__________________________________________________________________________|____________|
Liver | + + | 2 |
Hepatocellular Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 2 |
__________________________________________________________________________|____________|
Prostate | + + | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 0| 4| | |
DAY ON TEST | 6| 3| | |
| 7| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| | T |
ANIMAL ID | 0| 0| | A |
0.0MG/M3 | 4| 6| | L |
LUNG TOX | 2| 6| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M | |
__________________________________________________________________________|____________|
Spleen | + + | 2 |
__________________________________________________________________________|____________|
Thymus | + + | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M | |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 2 |
__________________________________________________________________________|____________|
Lung | + + | 2 |
__________________________________________________________________________|____________|
Nose | + + | 2 |
__________________________________________________________________________|____________|
Trachea | I + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 5| 6| 5| 7| 5| 0| 7| 5| 7| 5| 7| 7| 7| 5| 2|
DAY ON TEST | 1| 4| 7| 8| 4| 8| 3| 4| 3| 4| 4| 2| 3| 4| 4| 2| 4| 2| 1| 5| 3| 0| 3| 7| 4|
| 8| 1| 4| 8| 1| 0| 7| 0| 7| 0| 9| 0| 3| 0| 9| 0| 0| 1| 6| 9| 7| 4| 7| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6MG/M3 | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 2| 3| 4| 6| 8| 9| 0| 1| 3| 6| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Gallbladder | M + M + + + + + + + + + A + + A + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + M A + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + M + + + + + + + A M M A + + + + + M + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + A + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + A + + A + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + A + + A + + + + + + + + A|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + A + + A + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hemangioma | X |
Hepatocellular Carcinoma | X X X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Lymphoma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + A|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + A|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + A|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leiomyoma | |
__________________________________________________________________________|
Penis | + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 5| 6| 5| 7| 5| 0| 7| 5| 7| 5| 7| 7| 7| 5| 2|
DAY ON TEST | 1| 4| 7| 8| 4| 8| 3| 4| 3| 4| 4| 2| 3| 4| 4| 2| 4| 2| 1| 5| 3| 0| 3| 7| 4|
| 8| 1| 4| 8| 1| 0| 7| 0| 7| 0| 9| 0| 3| 0| 9| 0| 0| 1| 6| 9| 7| 4| 7| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6MG/M3 | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 2| 3| 4| 6| 8| 9| 0| 1| 3| 6| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + I M + + + M + + + I A|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + M + M + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + A|
Hemangiosarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + + + M I I I I M M M I + M + M M M I M I M A|
Lymphoma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hemangiosarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Thymus | + + + + + + I + + + + + + + M + + + + + M + + + A|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M A|
__________________________________________________________________________|
Skin | + + + + + + + + + I + + + + + + + + + + + + + + A|
Prepuce, Fibrous Histiocytoma | |
Tail, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + M + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + A|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X |
Lymphoma Malignant | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 5| 6| 5| 7| 5| 0| 7| 5| 7| 5| 7| 7| 7| 5| 2|
DAY ON TEST | 1| 4| 7| 8| 4| 8| 3| 4| 3| 4| 4| 2| 3| 4| 4| 2| 4| 2| 1| 5| 3| 0| 3| 7| 4|
| 8| 1| 4| 8| 1| 0| 7| 0| 7| 0| 9| 0| 3| 0| 9| 0| 0| 1| 6| 9| 7| 4| 7| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6MG/M3 | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 2| 3| 4| 6| 8| 9| 0| 1| 3| 6| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A|
Lymphoma Malignant | |
__________________________________________________________________________|
Urethra | + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 5| 6| 4| 4| 6| 4| 5| 6| 7| 5| 7| 5| 7| 7| 6| 7| 7| 5| 6| 7|
DAY ON TEST | 1| 1| 4| 3| 3| 6| 3| 6| 8| 7| 6| 2| 6| 4| 9| 4| 9| 4| 4| 8| 4| 4| 8| 9| 3|
| 5| 3| 0| 7| 7| 3| 6| 9| 4| 1| 9| 5| 1| 1| 2| 0| 0| 0| 0| 6| 0| 0| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 9| 0| 1| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + M + + + A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + M + M M + M M + + + M M + M M + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + A + + + A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + A + + + A + + + + A + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + A + + + A + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hepatocellular Carcinoma | X X X X X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | |
__________________________________________________________________________|
Penis | + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 5| 6| 4| 4| 6| 4| 5| 6| 7| 5| 7| 5| 7| 7| 6| 7| 7| 5| 6| 7|
DAY ON TEST | 1| 1| 4| 3| 3| 6| 3| 6| 8| 7| 6| 2| 6| 4| 9| 4| 9| 4| 4| 8| 4| 4| 8| 9| 3|
| 5| 3| 0| 7| 7| 3| 6| 9| 4| 1| 9| 5| 1| 1| 2| 0| 0| 0| 0| 6| 0| 0| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 9| 0| 1| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + I + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + I M + M + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + I I + I M M + + M M + I + + + + + M M I M + M|
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hemangiosarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | + + I + + I + + + + + + + + M + + + + + + + M + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M + M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + I + + + + + + + + + + +|
Prepuce, Fibrous Histiocytoma | X |
Tail, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + I + M + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 5| 6| 4| 4| 6| 4| 5| 6| 7| 5| 7| 5| 7| 7| 6| 7| 7| 5| 6| 7|
DAY ON TEST | 1| 1| 4| 3| 3| 6| 3| 6| 8| 7| 6| 2| 6| 4| 9| 4| 9| 4| 4| 8| 4| 4| 8| 9| 3|
| 5| 3| 0| 7| 7| 3| 6| 9| 4| 1| 9| 5| 1| 1| 2| 0| 0| 0| 0| 6| 0| 0| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 9| 0| 1| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Urethra | + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 1| 7| | |
DAY ON TEST | 4| 4| 3| 4| 4| 5| 6| 3| | |
| 1| 1| 7| 0| 1| 5| 3| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.6MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + M + | 38 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 50 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 57 |
Hemangioma | | 1 |
Hepatocellular Carcinoma | X | 15 |
Hepatocellular Carcinoma, Multiple | | 2 |
Hepatocellular Adenoma | X X | 8 |
Hepatocellular Adenoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 57 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 57 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 57 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + | 56 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 57 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 1| 7| | |
DAY ON TEST | 4| 4| 3| 4| 4| 5| 6| 3| | |
| 1| 1| 7| 0| 1| 5| 3| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.6MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 57 |
Leiomyoma | X | 1 |
__________________________________________________________________________|____________|
Penis | | 9 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Lymph Node | + | 11 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + | 52 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 55 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + I M M M M | 18 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 56 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + | 49 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 55 |
Prepuce, Fibrous Histiocytoma | | 1 |
Tail, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 1| 7| | |
DAY ON TEST | 4| 4| 3| 4| 4| 5| 6| 3| | |
| 1| 1| 7| 0| 1| 5| 3| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.6MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 57 |
Alveolar/Bronchiolar Adenoma | | 3 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 6 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 57 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Urethra | | 7 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 57 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 57 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 65
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 4| 0| | |
DAY ON TEST | 7| 3| | |
| 5| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| | T |
ANIMAL ID | 1| 2| | A |
0.6MG/M3 | 9| 2| | L |
LUNG TOX | 3| 3| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + A | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A | 1 |
__________________________________________________________________________|____________|
Liver | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + M | 1 |
__________________________________________________________________________|____________|
Prostate | + + | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 66
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 4| 0| | |
DAY ON TEST | 7| 3| | |
| 5| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| | T |
ANIMAL ID | 1| 2| | A |
0.6MG/M3 | 9| 2| | L |
LUNG TOX | 3| 3| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | I M | |
__________________________________________________________________________|____________|
Spleen | + + | 2 |
__________________________________________________________________________|____________|
Thymus | + + | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M | |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 2 |
__________________________________________________________________________|____________|
Lung | + + | 2 |
__________________________________________________________________________|____________|
Nose | + + | 2 |
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 6| 1| 7| 7| 6| 7| 4| 7| 4| 7| 6| 4| 7| 7| 7| 6| 7|
DAY ON TEST | 5| 7| 4| 4| 3| 3| 3| 4| 0| 4| 3| 1| 6| 0| 8| 1| 5| 3| 9| 6| 4| 4| 3| 0| 4|
| 9| 4| 1| 0| 7| 7| 7| 1| 7| 4| 7| 6| 5| 5| 5| 1| 0| 7| 5| 3| 0| 1| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.2MG/M3 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + A + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + M M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatoblastoma | |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Tooth | + |
Odontoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + M + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + M + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + I + + + + + + + + + + +|
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic | |
Thoracic, Alveolar/Bronchiolar | |
Carcinoma, Metastatic | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 6| 1| 7| 7| 6| 7| 4| 7| 4| 7| 6| 4| 7| 7| 7| 6| 7|
DAY ON TEST | 5| 7| 4| 4| 3| 3| 3| 4| 0| 4| 3| 1| 6| 0| 8| 1| 5| 3| 9| 6| 4| 4| 3| 0| 4|
| 9| 4| 1| 0| 7| 7| 7| 1| 7| 4| 7| 6| 5| 5| 5| 1| 0| 7| 5| 3| 0| 1| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.2MG/M3 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Interstitium, Granular Cell Tumor NOS| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | I I M + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +|
Adenocarcinoma, Metastatic, Stomach, | |
Glandular | X |
Fibrous Histiocytoma | |
Hemangioma | |
__________________________________________________________________________|
Lymph Node, Mediastinal | I M M M I + M I + I I + + + + + M I + M I M M M M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
__________________________________________________________________________|
Thymus | M + + M M I + + M M M + M + + M I M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Pinna, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 6| 1| 7| 7| 6| 7| 4| 7| 4| 7| 6| 4| 7| 7| 7| 6| 7|
DAY ON TEST | 5| 7| 4| 4| 3| 3| 3| 4| 0| 4| 3| 1| 6| 0| 8| 1| 5| 3| 9| 6| 4| 4| 3| 0| 4|
| 9| 4| 1| 0| 7| 7| 7| 1| 7| 4| 7| 6| 5| 5| 5| 1| 0| 7| 5| 3| 0| 1| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.2MG/M3 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma | X |
Hepatoblastoma, Metastatic, Liver | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma, Metastatic, Liver | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Urethra | + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 6| 2| 5| 7| 3| 6| 6| 7| 4| 7| 6| 6| 5| 4| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 3|
DAY ON TEST | 6| 5| 8| 4| 8| 4| 6| 3| 2| 4| 6| 4| 2| 6| 3| 6| 2| 4| 4| 3| 3| 6| 3| 3| 3|
| 1| 0| 5| 0| 5| 2| 1| 4| 4| 0| 5| 4| 4| 9| 7| 6| 6| 0| 0| 7| 7| 1| 2| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.2MG/M3 | 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 3| 6| 9| 1| 2| 3| 5| 6| 8| 0| 1| 2| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + M + + + M + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + M + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + A + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatoblastoma | X |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X |
__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
__________________________________________________________________________|
Tooth | + |
Odontoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + M + + + + M + M + + + M + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic | X |
Thoracic, Alveolar/Bronchiolar | |
Carcinoma, Metastatic | X |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 6| 2| 5| 7| 3| 6| 6| 7| 4| 7| 6| 6| 5| 4| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 3|
DAY ON TEST | 6| 5| 8| 4| 8| 4| 6| 3| 2| 4| 6| 4| 2| 6| 3| 6| 2| 4| 4| 3| 3| 6| 3| 3| 3|
| 1| 0| 5| 0| 5| 2| 1| 4| 4| 0| 5| 4| 4| 9| 7| 6| 6| 0| 0| 7| 7| 1| 2| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.2MG/M3 | 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 3| 6| 9| 1| 2| 3| 5| 6| 8| 0| 1| 2| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Interstitium, Granular Cell Tumor NOS| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | A |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + I + + + + + + + +|
Hepatocellular Carcinoma, Metastatic | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + M + M + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Stomach, | |
Glandular | |
Fibrous Histiocytoma | X |
Hemangioma | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M I A M M + M I + M + M I M I + + + + I + I M|
__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + M + + + + + + + +|
Hemangioma | X |
__________________________________________________________________________|
Thymus | + + + + + M + + + + M + M + I + + + + + + + + M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
Pinna, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + A + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
_____________________________________________________________________________________________________________________
| 6| 2| 5| 7| 3| 6| 6| 7| 4| 7| 6| 6| 5| 4| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 3|
DAY ON TEST | 6| 5| 8| 4| 8| 4| 6| 3| 2| 4| 6| 4| 2| 6| 3| 6| 2| 4| 4| 3| 3| 6| 3| 3| 3|
| 1| 0| 5| 0| 5| 2| 1| 4| 4| 0| 5| 4| 4| 9| 7| 6| 6| 0| 0| 7| 7| 1| 2| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.2MG/M3 | 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 3| 6| 9| 1| 2| 3| 5| 6| 8| 0| 1| 2| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatoblastoma, Metastatic, Liver | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma, Metastatic, Liver | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Urethra | + + + +|
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 7| | |
DAY ON TEST | 3| 4| 1| 3| 3| 4| 7| 3| | |
| 7| 0| 3| 9| 7| 0| 6| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| | A |
1.2MG/M3 | 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 3| 4| 5| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + A M | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + | 54 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + A + | 57 |
Hemangiosarcoma | | 1 |
Hepatoblastoma | | 1 |
Hepatocellular Carcinoma | X X | 12 |
Hepatocellular Adenoma | | 11 |
Hepatocellular Adenoma, Multiple | | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + | 56 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + A + | 57 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + A + | 55 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + | 55 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Tooth | + + | 4 |
Odontoma | X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + A + | 56 |
Capsule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + A + | 54 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + | 56 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + A + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + A M | 53 |
Pars Distalis, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + A + | 57 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 74
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 7| | |
DAY ON TEST | 3| 4| 1| 3| 3| 4| 7| 3| | |
| 7| 0| 3| 9| 7| 0| 6| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| | A |
1.2MG/M3 | 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 3| 4| 5| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic | | 1 |
Thoracic, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
Interstitium, Granular Cell Tumor NOS| X | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + A + | 57 |
__________________________________________________________________________|____________|
Penis | + | 8 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Prostate | + + + + + + A + | 57 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + A + | 57 |
__________________________________________________________________________|____________|
Testes | + + + + + + A + | 57 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A + | 57 |
__________________________________________________________________________|____________|
Lymph Node | + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + A + | 53 |
Hepatocellular Carcinoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + A + | 55 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + A + | 53 |
Adenocarcinoma, Metastatic, Stomach, | | |
Glandular | | 1 |
Fibrous Histiocytoma | | 1 |
Hemangioma | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | I I M + I I A M | 17 |
__________________________________________________________________________|____________|
Spleen | + + + + + + A + | 55 |
Hemangioma | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + M + + A + | 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + A + | 57 |
Fibrous Histiocytoma | | 1 |
Pinna, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 75
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 7| | |
DAY ON TEST | 3| 4| 1| 3| 3| 4| 7| 3| | |
| 7| 0| 3| 9| 7| 0| 6| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| | A |
1.2MG/M3 | 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 3| 4| 5| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + A + | 57 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + A + | 57 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + A + | 57 |
__________________________________________________________________________|____________|
Lung | + + + + + + A + | 56 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | X | 4 |
Hepatoblastoma, Metastatic, Liver | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + A + | 57 |
__________________________________________________________________________|____________|
Trachea | + + + M + + M + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + A + | 57 |
Hepatoblastoma, Metastatic, Liver | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
__________________________________________________________________________|____________|
Urethra | | 11 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + | 56 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 76
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 3| 1| | |
DAY ON TEST | 9| 1| | |
| 1| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| | T |
ANIMAL ID | 3| 3| | A |
1.2MG/M3 | 5| 9| | L |
LUNG TOX | 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | A + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + | 1 |
__________________________________________________________________________|____________|
Liver | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 2 |
__________________________________________________________________________|____________|
Prostate | + + | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:10:04
__________________________________________________________________________________________________________________________________
| 3| 1| | |
DAY ON TEST | 9| 1| | |
| 1| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| | T |
ANIMAL ID | 3| 3| | A |
1.2MG/M3 | 5| 9| | L |
LUNG TOX | 8| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | A M | |
__________________________________________________________________________|____________|
Spleen | + + | 2 |
__________________________________________________________________________|____________|
Thymus | + + | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M | |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 2 |
__________________________________________________________________________|____________|
Lung | + + | 2 |
__________________________________________________________________________|____________|
Nose | + + | 2 |
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 78
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---------- END OF REPORT ----------
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