TDMS Study 05107-06 Pathology Tables
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:12:03
68 Week SSAC
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 12035722
Lock Date: 10/14/92
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 01/17/90 - 01/17/90
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:12:03
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 0| 1| 1| 2| 3| 4| 4| 6| 7| | L |
LUNG TOX | 6| 3| 8| 8| 0| 1| 5| 5| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Hepatocellular Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | M + M + + | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 5 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Prostate | + + + + + | 5 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 5 |
__________________________________________________________________________|____________|
Testes | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | I + + + + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 2
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:12:03
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 0| 1| 1| 2| 3| 4| 4| 6| 7| | L |
LUNG TOX | 6| 3| 8| 8| 0| 1| 5| 5| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 5 |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________|____________|
Urethra | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 3
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:12:03
__________________________________________________________________________________________________________________________________
| 4| 4| | |
DAY ON TEST | 7| 7| | |
| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| | T |
ANIMAL ID | 1| 1| | A |
0.6MG/M3 | 7| 9| | L |
| 7| 7| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 1 |
__________________________________________________________________________|____________|
Gallbladder | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | M | |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Liver | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
__________________________________________________________________________|____________|
Prostate | + | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
__________________________________________________________________________|____________|
Testes | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 4
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:12:03
__________________________________________________________________________________________________________________________________
| 4| 4| | |
DAY ON TEST | 7| 7| | |
| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| | T |
ANIMAL ID | 1| 1| | A |
0.6MG/M3 | 7| 9| | L |
| 7| 7| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M | |
__________________________________________________________________________|____________|
Spleen | + | 1 |
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M | |
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 1 |
__________________________________________________________________________|____________|
Lung | + | 1 |
__________________________________________________________________________|____________|
Nose | + | 1 |
__________________________________________________________________________|____________|
Trachea | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:12:03
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| | |
| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| | A |
0.6MG/M3 | 6| 6| 7| 8| 9| 0| 0| 3| | L |
LUNG TOX | 1| 5| 4| 7| 2| 2| 8| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 4 |
__________________________________________________________________________|____________|
Gallbladder | + + + + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 4 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 4 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 4 |
__________________________________________________________________________|____________|
Liver | + + + + | 4 |
Hepatocellular Adenoma | X X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 4 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 4 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 4 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 4 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 4 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 4 |
__________________________________________________________________________|____________|
Prostate | + + + + | 4 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 4 |
__________________________________________________________________________|____________|
Testes | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 4 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:12:03
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| | |
| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| | A |
0.6MG/M3 | 6| 6| 7| 8| 9| 0| 0| 3| | L |
LUNG TOX | 1| 5| 4| 7| 2| 2| 8| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + I + I | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M + M | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + | 4 |
__________________________________________________________________________|____________|
Thymus | + + + M | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + I + | 3 |
__________________________________________________________________________|____________|
Lung | + + + + | 4 |
__________________________________________________________________________|____________|
Nose | + + + + | 4 |
__________________________________________________________________________|____________|
Trachea | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:12:03
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| | |
| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.2MG/M3 | 2| 3| 4| 5| 6| 6| 7| 9| | L |
LUNG TOX | 6| 2| 1| 4| 0| 7| 7| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Hepatocellular Carcinoma | X | 1 |
Hepatocellular Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 5 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Prostate | + + + + + | 5 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 5 |
__________________________________________________________________________|____________|
Testes | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05107-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 03/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:12:03
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| | |
| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.2MG/M3 | 2| 3| 4| 5| 6| 6| 7| 9| | L |
LUNG TOX | 6| 2| 1| 4| 0| 7| 7| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M + I + | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + I | 4 |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
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