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TDMS Study 05107-06 Pathology Tables

NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:12:03

                                                          68 Week SSAC




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  12035722

       Lock Date:  10/14/92

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     01/17/90 - 01/17/90

       Treatment Groups:       Include All


































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:12:03  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4|                                               |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7|                                               |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6|                                               |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     A      |
    0.0MG/M3                               | 0| 1| 1| 2| 3| 4| 4| 6| 7|                                               |     L      |
    LUNG TOX                               | 6| 3| 8| 8| 0| 1| 5| 5| 5|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +     +  +        +                                                |   5        |
      Hepatocellular Adenoma               |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | M     +     M  +        +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +     +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +     +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     M     +  M        +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +     +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +     +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | I     +     +  +        +                                                |   4        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   2                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:12:03  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4|                                               |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7|                                               |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6|                                               |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     A      |
    0.0MG/M3                               | 0| 1| 1| 2| 3| 4| 4| 6| 7|                                               |     L      |
    LUNG TOX                               | 6| 3| 8| 8| 0| 1| 5| 5| 5|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M     M     M  +        +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M     M     M  M        +                                                |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +     +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M     M     M  M        M                                                |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +     +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +     +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +     +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +     +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +     +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Urethra                                 | +              +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +     +  +        +                                                |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +     +  +        +                                                |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   3                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:12:03  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4|                                                                    |            |
                             DAY ON TEST   | 7| 7|                                                                    |            |
                                           | 6| 6|                                                                    |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0|                                                                    |     O      |
   B6C3F1 MICE MALE                        | 0| 0|                                                                    |     T      |
                               ANIMAL ID   | 1| 1|                                                                    |     A      |
    0.6MG/M3                               | 7| 9|                                                                    |     L      |
                                           | 7| 7|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | M                                                                        |            |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   4                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:12:03  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4|                                                                    |            |
                             DAY ON TEST   | 7| 7|                                                                    |            |
                                           | 6| 6|                                                                    |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0|                                                                    |     O      |
   B6C3F1 MICE MALE                        | 0| 0|                                                                    |     T      |
                               ANIMAL ID   | 1| 1|                                                                    |     A      |
    0.6MG/M3                               | 7| 9|                                                                    |     L      |
                                           | 7| 7|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M                                                                        |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M                                                                        |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |   1        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +                                                                        |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   5                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:12:03  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7|                                                  |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2|                                                  |     A      |
    0.6MG/M3                               | 6| 6| 7| 8| 9| 0| 0| 3|                                                  |     L      |
    LUNG TOX                               | 1| 5| 4| 7| 2| 2| 8| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +     +                                                            |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +                                                            |   4        |
      Hepatocellular Adenoma               | X           X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +     M                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +     +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +                                                            |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   6                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:12:03  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7|                                                  |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2|                                                  |     A      |
    0.6MG/M3                               | 6| 6| 7| 8| 9| 0| 0| 3|                                                  |     L      |
    LUNG TOX                               | 1| 5| 4| 7| 2| 2| 8| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  I  +     I                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M     +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  +     M                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +     M                                                            |   3        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M     M                                                            |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  I     +                                                            |   3        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +                                                            |   4        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +     +                                                            |   4        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   7                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:12:03  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7|                                                  |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3|                                                  |     A      |
    1.2MG/M3                               | 2| 3| 4| 5| 6| 6| 7| 9|                                                  |     L      |
    LUNG TOX                               | 6| 2| 1| 4| 0| 7| 7| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          +  +  +  +  M                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          M  +  +  +  +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   |          +  +  +  +  +                                                   |   5        |
      Hepatocellular Carcinoma             |             X                                                            |          1 |
      Hepatocellular Adenoma               |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +  +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          M  M  +  +  M                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Prostate                                |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Testes                                  |          +  +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +  +  +  +                                                   |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   8                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:12:03  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7|                                                  |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3|                                                  |     A      |
    1.2MG/M3                               | 2| 3| 4| 5| 6| 6| 7| 9|                                                  |     L      |
    LUNG TOX                               | 6| 2| 1| 4| 0| 7| 7| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +  +  +  M  +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |          M  M  +  I  +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +  +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M  M  M  M  M                                                   |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |          +  +  +  +  I                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +  +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  +  +  +  +                                                   |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |          +  +  +  +  +                                                   |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   9                                                               
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