TDMS Study 05107-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: LITRI NICKEL SUBSULFIDE DATE: 05/19/95
EXPERIMENT: 05107 TEST: 06 TIME: 23:03:13
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: Y01ES30108 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C61654
PATHOLOGIST: F. HAHN CAS: 12035722
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: LITRI NICKEL SUBSULFIDE DATE: 05/19/95
EXPERIMENT: 05107 TEST: 06 TIME: 23:03:13
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: Y01ES30108 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C61654
PATHOLOGIST: F. HAHN CAS: 12035722
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0MG/M3 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 33 CENSORED DEATHS 1 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 212 313 406 463 480 499 508 526 536 544 |
| 552 552 557 561 584 584 585 586 588 589 |
| 591 605 620 631 641 662 679 681 681 681 |
| 694 713 719 |
| CENSORED DEATHS |
| 476 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.0MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 2 CENSORED DEATHS 18 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 67 434 |
| CENSORED DEATHS |
| 196 196 196 196 196 196 196 196 196 476 |
| 476 476 476 476 476 476 476 476 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.6MG/M3 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 33 CENSORED DEATHS 2 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 20 163 244 355 415 469 469 484 513 521 |
| 525 533 549 549 559 563 570 580 581 588 |
| 590 592 618 620 636 661 671 674 686 692 |
| 704 716 731 |
| CENSORED DEATHS |
| 476 476 |
| |
==================================================================================
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.6MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 2 CENSORED DEATHS 18 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 37 475 |
| CENSORED DEATHS |
| 196 196 196 196 196 196 196 196 196 196 |
| 476 476 476 476 476 476 476 476 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.2MG/M3 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 33 CENSORED DEATHS 2 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 144 250 335 374 385 424 450 459 463 469 |
| 485 524 532 539 585 607 607 626 642 644 |
| 661 661 661 665 665 666 676 695 705 711 |
| 713 716 734 |
| CENSORED DEATHS |
| 476 476 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.2MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 2 CENSORED DEATHS 18 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 118 391 |
| CENSORED DEATHS |
| 196 196 196 196 196 196 196 196 196 196 |
| 476 476 476 476 476 476 476 476 |
| |
==================================================================================
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 737 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0MG/M3 | 100.0 100.0 98.3 96.7 95.0 91.6 83.2 62.8 56.0 44.1 |
| | |
| | |
|0.0MG/M3LUN| 95.0 95.0 95.0 95.0 95.0 0.0 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
|0.6MG/M3 | 98.3 96.7 95.0 93.3 91.7 86.6 79.7 62.4 55.4 43.3 |
| | |
| | |
|0.6MG/M3LUN| 95.0 95.0 95.0 95.0 95.0 0.0 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
|1.2MG/M3 | 100.0 98.3 96.7 95.0 90.0 81.6 76.4 74.7 57.3 43.4 |
| | |
| | |
|1.2MG/M3LUN| 100.0 95.0 95.0 95.0 84.4 0.0 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
==================================================================================
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0MG/M3 0.0MG/M3LUNG 0.6MG/M3 0.6MG/M3LUNG 1.2MG/M3 1.2MG/M3LUNG |
| TOX TOX TOX |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 44.1% 0.0% 43.3% 0.0% 43.4% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000 ----- P=0.926 P=0.510 P=1.000 P=0.481 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 570.4 250.5 540.6 256.0 559.8 254.5 |
|NATURAL DEATHS (C) | (19.1) ( 184) (27.3) ( 219) (25.6) ( 137) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 641.0 327.5 620.3 314.0 630.8 313.9 |
|(STANDARD ERROR) | (15.2) (33.8) (19.7) (34.5) (18.3) (32.2) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0MG/M3 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 2 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 288 300 385 419 508 536 552 563 598 600 |
| 603 645 649 674 679 680 683 691 694 696 |
| 723 727 |
| CENSORED DEATHS |
| 477 477 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.0MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 18 UNCENSORED DEATHS 0 CENSORED DEATHS 18 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 197 197 197 197 197 197 197 197 197 197 |
| 477 477 477 477 477 477 477 477 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.6MG/M3 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 112 116 206 403 425 520 530 536 552 563 |
| 605 623 636 642 652 653 655 655 655 692 |
| 694 711 712 717 720 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.6MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 0 CENSORED DEATHS 20 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 197 197 197 197 197 197 197 197 197 197 |
| 477 477 477 477 477 477 477 477 477 477 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.2MG/M3 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 2 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 239 340 499 507 563 580 580 580 588 607 |
| 628 630 632 653 672 685 703 729 732 732 |
| CENSORED DEATHS |
| 477 477 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.2MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 2 CENSORED DEATHS 18 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 74 445 |
| CENSORED DEATHS |
| 197 197 197 197 197 197 197 197 197 197 |
| 477 477 477 477 477 477 477 477 |
| |
==================================================================================
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0MG/M3 | 100.0 100.0 100.0 96.7 93.3 93.3 89.9 81.2 77.8 62.2 |
| | |
| | |
|0.0MG/M3LUN| 100.0 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
|0.6MG/M3 | 100.0 96.7 95.0 95.0 91.7 91.7 86.7 81.7 68.3 56.7 |
| | |
| | |
|0.6MG/M3LUN| 100.0 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
|1.2MG/M3 | 100.0 100.0 98.3 96.7 96.7 96.7 93.2 84.6 76.0 65.6 |
| | |
| | |
|1.2MG/M3LUN| 95.0 95.0 95.0 95.0 95.0 84.4 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
==================================================================================
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0MG/M3 0.0MG/M3LUNG 0.6MG/M3 0.6MG/M3LUNG 1.2MG/M3 1.2MG/M3LUNG |
| TOX TOX TOX |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.2% 0.0% 56.7% 0.0% 65.6% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.979N ----- P=0.643 P=0.905N P=0.808N P=0.510 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 586.0 . 565.9 . 594.0 259.5 |
|NATURAL DEATHS (C) | (28.1) ( . ) (34.9) ( . ) (28.0) ( 186) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 670.6 321.4 660.6 337.0 678.1 315.3 |
|(STANDARD ERROR) | (14.4) (33.7) (18.4) (32.1) (13.4) (33.4) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NICKEL SUBSULFIDE
KAPLAN-MEIER SURVIVAL CURVES
0.0MG/M3 = 1
0.0MG/M3LUNG TOX = 2
0.6MG/M3 = 3
0.6MG/M3LUNG TOX = 4
1.2MG/M3 = 5
1.2MG/M3LUNG TOX = 6
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
100 + 1 3 4 2 6 5 1
| 3 5 3 1 35 1 5 1
| 4 2 6 3 5 3 5 6 1 2 14
| 3 5 5 35 1 1 1
90 + 5 5 11
| 553 3 13 11
| 6 2 42 3 3 11
| 5 5 3 311
80 + 553 11
| 55 11 1
| 333 5 5
| 33
P 70 + 33 5 5 5
E | 31 1
R | 3 1 1 5 5
C | 3 1 1
E 60 + 1 11
N | 31 15
T | 1311 5
| 333 55
S 50 + 13155
U | 31313
R | 11 31
V | 33
I 40 +
V |
A |
L |
30 +
|
|
|
20 +
|
|
|
10 +
|
|
|
0 + 2
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 52 obs hidden.
NICKEL SUBSULFIDE
KAPLAN-MEIER SURVIVAL CURVES
0.0MG/M3 = 1
0.0MG/M3LUNG TOX = 2
0.6MG/M3 = 3
0.6MG/M3LUNG TOX = 4
1.2MG/M3 = 5
1.2MG/M3LUNG TOX = 6
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
100 + 1 6 3 5 1 2
| 33 3 5 11 5 1 5
| 6 3 1 3 1 6 55
| 3 13 1 3 1 5 5
90 + 331 1
| 33 1 1 55 1
| 6 6 3 3 5 5
| 3 11 35
80 + 1 353 1
| 3313 1
| 5 511
| 5 5
P 70 + 1115 5
E | 3 33
R | 1 3 1 5
C | 331 1
E 60 +
N | 33 3
T |
|
S 50 +
U |
R |
V |
I 40 +
V |
A |
L |
30 +
|
|
|
20 +
|
|
|
10 +
|
|
|
0 + 2
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 31 obs hidden.