TDMS Study 05107-05 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
NICKEL SUBSULFIDE
NTP Experiment-Test: 05107-05 Report: PEIRPT03
Study Type: CHRONIC Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 12035722
Lock Date: 09/30/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 10 60 10 60 10
Scheduled Sacrifice 2 5 2 5 2 5
Early Deaths
Moribund Sacrifice 24 27 23
Natural Death 4 1 1
Accidently Killed 1
Survivors
Terminal Sacrifice 25 25 28
Animals Examined Microscopically 58 5 58 5 58 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (55) (57) (58)
Parasite Metazoan 1 (2%)
Intestine Large, Rectum (46) (43) (42)
Parasite Metazoan 2 (5%)
Intestine Large, Cecum (54) (57) (57)
Inflammation 1 (2%)
Parasite Metazoan 2 (4%) 2 (4%) 3 (5%)
Intestine Small, Jejunum (55) (57) (57)
Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Ileum (55) (57) (58)
Hyperplasia, Lymphoid 3 (5%) 5 (9%) 3 (5%)
Liver (58) (58) (58) (1)
Angiectasis 1 (2%)
Basophilic Focus 47 (81%) 49 (84%) 45 (78%)
Clear Cell Focus 1 (2%)
Degeneration, Cystic 1 (2%) 4 (7%) 2 (3%)
Degeneration, Fatty 16 (28%) 12 (21%) 11 (19%)
Eosinophilic Focus 3 (5%) 2 (3%) 5 (9%)
Granuloma 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 7 (12%) 4 (7%) 2 (3%)
Inflammation, Focal, Granulomatous 24 (41%) 22 (38%) 13 (22%)
Inflammation, Granulomatous 4 (7%) 2 (3%) 5 (9%)
Mixed Cell Focus 3 (5%) 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 3 (5%) 1 (2%) 7 (12%)
Regeneration 2 (3%)
Bile Duct, Hyperplasia 18 (31%) 13 (22%) 14 (24%)
Biliary Tract, Hyperplasia 1 (2%)
Centrilobular, Atrophy 9 (16%) 5 (9%) 14 (24%)
Hepatocyte, Atrophy 1 (2%)
Hepatocyte, Hyperplasia 4 (7%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Necrosis 1 (2%) 1 (2%)
Vein, Thrombosis 1 (2%)
Mesentery (1) (2)
Necrosis 1 (50%)
Fat, Necrosis 1 (100%)
Pancreas (58) (57) (58)
Atrophy 10 (17%) 4 (7%) 14 (24%)
Stomach, Forestomach (58) (58) (58)
Hyperplasia, Squamous 2 (3%) 5 (9%) 2 (3%)
Inflammation 1 (2%)
Ulcer 3 (5%) 1 (2%)
Tooth (1) (1)
Peridontal Tissue, Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Inflammation 1 (100%)
Heart (58) (58) (58)
Cardiomyopathy 25 (43%) 17 (29%) 18 (31%)
Atrium, Thrombosis 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (58) (58) (58)
Degeneration, Cystic 11 (19%) 11 (19%) 19 (33%)
Hyperplasia 2 (3%)
Hyperplasia, Focal 1 (2%) 5 (9%)
Necrosis 2 (3%)
Vacuolization Cytoplasmic 4 (7%) 3 (5%) 6 (10%)
Adrenal Medulla (58) (56) (58)
Hyperplasia 5 (9%) 11 (20%) 16 (28%)
Islets, Pancreatic (58) (58) (58)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (52) (55) (54)
Hyperplasia 1 (2%) 2 (4%) 3 (6%)
Pituitary Gland (57) (58) (58)
Cyst 1 (2%)
Pars Distalis, Angiectasis 21 (37%) 11 (19%) 16 (28%)
Pars Distalis, Cyst 3 (5%) 3 (5%)
Pars Distalis, Hyperplasia 13 (23%) 5 (9%) 14 (24%)
Thyroid Gland (56) (58) (57)
C-Cell, Hyperplasia 16 (29%) 12 (21%) 12 (21%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (57) (57) (57)
Hyperplasia, Cystic 6 (11%) 5 (9%) 5 (9%)
Inflammation 1 (2%)
Ovary (58) (1) (58) (1) (58) (1)
Atrophy 1 (2%)
Cyst 5 (9%) 1 (100%) 3 (5%) 1 (100%) 6 (10%) 1 (100%)
Inflammation 2 (3%)
Uterus (58) (58) (58)
Cyst 1 (2%)
Inflammation 1 (2%)
Endometrium, Hyperplasia, Cystic 3 (5%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (58) (58) (58)
Atrophy 2 (3%)
Fibrosis 2 (3%) 3 (5%)
Inflammation, Focal, Granulomatous 4 (7%) 1 (2%)
Necrosis 1 (2%)
Erythroid Cell, Hyperplasia 1 (2%)
Myeloid Cell, Hyperplasia 2 (3%) 2 (3%)
Lymph Node (5) (3) (10)
Pancreatic, Hyperplasia, Lymphoid 1 (33%) 1 (10%)
Pancreatic, Hyperplasia, Macrophage 1 (10%)
Renal, Hyperplasia, Lymphoid 1 (20%)
Lymph Node, Bronchial (55) (5) (54) (5) (55) (5)
Hemorrhage, Acute 1 (2%)
Hyperplasia, Lymphoid 11 (20%) 2 (40%) 37 (69%) 2 (40%) 38 (69%) 5 (100%)
Hyperplasia, Macrophage 1 (2%) 18 (33%) 28 (51%)
Hyperplasia, Plasma Cell 2 (4%)
Inflammation 1 (2%)
Lymph Node, Mandibular (49) (53) (56)
Hyperplasia, Lymphoid 3 (6%) 5 (9%) 1 (2%)
Hyperplasia, Plasma Cell 3 (6%) 6 (11%) 4 (7%)
Lymph Node, Mesenteric (57) (58) (57)
Atrophy 1 (2%)
Hyperplasia, Lymphoid 3 (5%) 5 (9%) 6 (11%)
Hyperplasia, Macrophage 1 (2%) 3 (5%)
Lymph Node, Mediastinal (51) (5) (55) (4) (52) (5)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (20%) 11 (20%) 1 (25%) 21 (40%) 5 (100%)
Hyperplasia, Macrophage 1 (2%) 5 (9%) 7 (13%)
Spleen (58) (58) (58)
Atrophy 1 (2%)
Fibrosis 2 (3%) 2 (3%)
Hematopoietic Cell Proliferation 3 (5%) 3 (5%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 7 (12%) 12 (21%) 2 (3%)
Thymus (54) (56) (55)
Degeneration 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (58) (58)
Fibrosis 1 (2%)
Hyperplasia, Cystic 11 (19%) 14 (24%) 16 (28%)
Skin (58) (58) (58)
Hyperkeratosis 1 (2%)
Inflammation 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%)
Tail, Hyperkeratosis 1 (2%)
Tail, Inflammation 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (58) (58) (58)
Hyperostosis 5 (9%) 3 (5%) 7 (12%)
Cranium, Hyperostosis 3 (5%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (58) (58) (58)
Cyst 1 (2%)
Hemorrhage 1 (2%)
Hydrocephalus 1 (2%) 1 (2%) 2 (3%)
Cerebrum, Compression 5 (9%) 10 (17%) 5 (9%)
Gray Matter, Necrosis 1 (2%)
Spinal Cord (1)
Degeneration, Secondary Wallerian 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (57) (58) (56)
Hyperplasia, Squamous 1 (2%)
Inflammation 2 (4%) 2 (3%) 3 (5%)
Lung (58) (5) (58) (5) (58) (5)
Cyst 1 (2%)
Emphysema 1 (2%)
Fibrosis 50 (86%) 44 (76%)
Hemorrhage, Acute 2 (3%) 3 (5%) 2 (3%)
Inflammation, Chronic Active 7 (12%) 56 (97%) 5 (100%) 56 (97%) 5 (100%)
Metaplasia, Osseous 1 (2%) 1 (20%) 1 (2%)
Metaplasia, Squamous 2 (3%)
Alveolar Epithelium, Hyperplasia, Focal 2 (3%) 10 (17%) 11 (19%)
Alveolus, Hyperplasia, Macrophage 9 (16%) 56 (97%) 5 (100%) 57 (98%) 5 (100%)
Alveolus, Proteinosis 2 (3%) 54 (93%) 2 (40%) 58 (100%) 5 (100%)
Bronchus, Hyperplasia, Lymphoid 15 (26%) 1 (20%) 19 (33%) 4 (80%)
Interstitium, Infiltration Cellular 28 (48%) 2 (40%) 40 (69%) 5 (100%) 48 (83%) 5 (100%)
Nose (58) (5) (58) (5) (57) (5)
Inflammation, Chronic Active 9 (16%) 1 (20%) 11 (19%) 2 (40%) 22 (39%) 4 (80%)
Thrombosis 2 (3%) 1 (2%)
Nasolacrimal Duct, Hyperplasia 1 (2%)
Nasolacrimal Duct, Inflammation 1 (2%) 2 (3%) 2 (4%)
Olfactory Epithelium, Atrophy 17 (30%)
Olfactory Epithelium, Erosion, Focal 1 (20%) 2 (40%)
Olfactory Epithelium, Metaplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2) (1) (2)
Cataract 2 (100%) 2 (100%) 2 (100%)
Retina, Degeneration 2 (100%) 1 (50%)
Lacrimal Gland (1)
Metaplasia, Squamous 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (5) (58) (5) (58) (5)
Cyst 1 (2%)
Hydronephrosis 1 (2%)
Nephropathy 52 (90%) 54 (93%) 52 (90%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Pigmentation 40 (69%) 43 (74%) 43 (74%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 10 60 10 60 10
Scheduled Sacrifice 5 5 5 5 5 5
Early Deaths
Moribund Sacrifice 35 28 33
Natural Death 5 4 2
Survivors
Terminal Sacrifice 13 21 18
Animals Examined Microscopically 58 5 58 5 58 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (56) (56) (58)
Inflammation 3 (5%)
Mineralization 1 (2%)
Parasite Metazoan 1 (2%) 1 (2%)
Intestine Large, Rectum (51) (50) (57)
Inflammation 1 (2%)
Parasite Metazoan 4 (8%) 1 (2%) 2 (4%)
Intestine Large, Cecum (56) (54) (57)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Inflammation 2 (4%) 4 (7%)
Parasite Metazoan 1 (2%) 2 (4%) 1 (2%)
Intestine Small, Duodenum (57) (57) (58)
Ulcer 2 (3%)
Intestine Small, Jejunum (56) (56) (57)
Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Ileum (56) (56) (57)
Hyperplasia, Lymphoid 4 (7%) 5 (9%) 3 (5%)
Liver (58) (58) (58)
Angiectasis 3 (5%) 1 (2%)
Basophilic Focus 29 (50%) 35 (60%) 35 (60%)
Clear Cell Focus 1 (2%) 1 (2%)
Degeneration, Cystic 11 (19%) 15 (26%) 15 (26%)
Degeneration, Fatty 9 (16%) 2 (3%) 7 (12%)
Eosinophilic Focus 6 (10%) 6 (10%) 6 (10%)
Hepatodiaphragmatic Nodule 3 (5%) 2 (3%) 4 (7%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%) 2 (3%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 40 (69%) 45 (78%) 39 (67%)
Biliary Tract, Hyperplasia 1 (2%)
Centrilobular, Atrophy 12 (21%) 16 (28%) 13 (22%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Hyperplasia 3 (5%) 1 (2%) 2 (3%)
Hepatocyte, Necrosis 4 (7%) 7 (12%) 4 (7%)
Mesentery (1) (1) (1)
Inflammation 1 (100%)
Fat, Necrosis 1 (100%)
Pancreas (58) (58) (58)
Atrophy 15 (26%) 15 (26%) 25 (43%)
Hyperplasia 1 (2%)
Salivary Glands (58) (57) (58)
Infarct 1 (2%) 1 (2%)
Stomach, Forestomach (58) (58) (58)
Diverticulum 1 (2%)
Hyperkeratosis 1 (2%) 3 (5%)
Hyperplasia, Squamous 1 (2%) 5 (9%)
Mineralization 1 (2%)
Ulcer 4 (7%) 1 (2%) 6 (10%)
Stomach, Glandular (58) (58) (58)
Necrosis, Focal 1 (2%) 2 (3%) 3 (5%)
Epithelium, Mineralization 1 (2%) 1 (2%)
Tooth (1) (1) (1)
Dysplasia 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Inflammation 1 (100%)
Mineralization 1 (100%)
Heart (58) (58) (58)
Cardiomyopathy 37 (64%) 37 (64%) 36 (62%)
Embolus 1 (2%)
Inflammation 2 (3%)
Mineralization 1 (2%) 1 (2%)
Atrium, Thrombosis 7 (12%) 6 (10%) 4 (7%)
Valve, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (57) (58) (58)
Atrophy 1 (2%)
Degeneration, Cystic 2 (4%) 3 (5%) 5 (9%)
Hyperplasia, Diffuse 1 (2%)
Hyperplasia, Focal 3 (5%) 2 (3%) 2 (3%)
Necrosis 2 (4%) 1 (2%)
Vacuolization Cytoplasmic 23 (40%) 7 (12%) 12 (21%)
Adrenal Medulla (58) (57) (58)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 26 (45%) 22 (39%) 11 (19%)
Bilateral, Thrombosis 1 (2%)
Islets, Pancreatic (58) (58) (58)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (55) (55) (56)
Hyperplasia 8 (15%) 6 (11%) 1 (2%)
Pituitary Gland (58) (57) (58)
Cyst 1 (2%)
Pars Distalis, Angiectasis 4 (7%) 9 (16%) 3 (5%)
Pars Distalis, Cyst 1 (2%) 1 (2%) 3 (5%)
Pars Distalis, Hyperplasia 17 (29%) 12 (21%) 13 (22%)
Thyroid Gland (57) (58) (58)
C-Cell, Hyperplasia 7 (12%) 8 (14%) 7 (12%)
Follicle, Hyperplasia 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (39) (47) (48)
Inflammation 1 (3%) 3 (6%) 1 (2%)
Epididymis (58) (58) (58)
Granuloma Sperm 3 (5%)
Inflammation 1 (2%)
Penis (2) (1)
Concretion 2 (100%)
Preputial Gland (58) (58) (58) (1)
Ectasia 2 (3%) 1 (2%) 2 (3%) 1 (100%)
Hyperplasia 3 (5%) 1 (2%) 1 (2%)
Inflammation 2 (3%) 6 (10%) 4 (7%)
Prostate (58) (58) (58)
Inflammation 2 (3%) 3 (5%)
Seminal Vesicle (57) (58) (57)
Atrophy 1 (2%) 2 (3%) 2 (4%)
Epithelium, Hyperplasia 1 (2%)
Testes (58) (58) (58)
Germinal Epithelium, Degeneration 7 (12%) 13 (22%) 13 (22%)
Interstitial Cell, Hyperplasia 14 (24%) 16 (28%) 18 (31%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (58) (57) (58)
Atrophy 4 (7%) 3 (5%) 2 (3%)
Fibrosis 2 (3%) 1 (2%)
Granuloma 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%) 1 (2%)
Myeloid Cell, Hyperplasia 1 (2%) 1 (2%) 5 (9%)
Lymph Node (5) (16) (6)
Iliac, Hyperplasia, Lymphoid 1 (6%)
Pancreatic, Hyperplasia, Lymphoid 1 (17%)
Renal, Angiectasis 1 (20%)
Renal, Pigmentation 1 (6%)
Lymph Node, Bronchial (57) (4) (56) (5) (57) (5)
Angiectasis 1 (2%)
Ectasia 1 (2%)
Hyperplasia, Lymphoid 5 (9%) 34 (61%) 4 (80%) 38 (67%) 5 (100%)
Hyperplasia, Macrophage 1 (2%) 18 (32%) 32 (56%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%) 1 (2%)
Lymph Node, Mandibular (55) (56) (54)
Hyperplasia, Lymphoid 4 (7%) 7 (13%) 3 (6%)
Hyperplasia, Plasma Cell 6 (11%) 10 (18%) 4 (7%)
Inflammation 2 (4%)
Lymph Node, Mesenteric (58) (58) (58)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Hyperplasia, Lymphoid 5 (9%) 11 (19%) 6 (10%)
Hyperplasia, Macrophage 1 (2%)
Inflammation 1 (2%)
Lymph Node, Mediastinal (53) (5) (54) (5) (53) (5)
Angiectasis 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 15 (28%) 5 (100%) 9 (17%) 3 (60%)
Hyperplasia, Macrophage 2 (4%)
Inflammation 1 (2%)
Spleen (58) (58) (58)
Atrophy 3 (5%) 2 (3%) 1 (2%)
Fibrosis 10 (17%) 13 (22%) 12 (21%)
Hematopoietic Cell Proliferation 2 (3%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 4 (7%) 1 (2%)
Infarct 2 (3%)
Pigmentation, Hemosiderin 2 (3%) 3 (5%)
Thymus (55) (53) (53)
Degeneration 17 (31%) 3 (6%) 10 (19%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (53) (53) (48)
Hyperplasia, Cystic 8 (15%) 2 (4%) 2 (4%)
Skin (58) (58) (58)
Cyst Epithelial Inclusion 2 (3%) 1 (2%) 1 (2%)
Conjunctiva, Inflammation 1 (2%)
Dermis, Inflammation 1 (2%)
Subcutaneous Tissue, Inflammation 1 (2%)
Tail, Hyperkeratosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (58) (57) (58)
Fibrous Osteodystrophy 1 (2%)
Hyperostosis 1 (2%) 4 (7%) 1 (2%)
Mandible, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (58) (58) (58)
Compression 1 (2%)
Cyst 1 (2%)
Embolus 1 (2%)
Necrosis 1 (2%)
Cerebrum, Atrophy, Focal 1 (2%)
Cerebrum, Compression 6 (10%) 4 (7%) 4 (7%)
Gray Matter, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (54) (57) (57)
Hyperplasia 4 (7%)
Inflammation 3 (6%) 2 (4%) 2 (4%)
Lung (58) (5) (58) (5) (58) (5)
Embolus 1 (2%)
Emphysema 1 (2%) 1 (2%)
Fibrosis 2 (3%) 48 (83%) 40 (69%)
Hemorrhage, Acute 7 (12%) 1 (2%)
Inflammation, Chronic Active 9 (16%) 1 (20%) 58 (100%) 5 (100%) 56 (97%) 5 (100%)
Metaplasia, Osseous 2 (3%) 2 (3%) 1 (20%) 2 (3%)
Metaplasia, Squamous 2 (3%)
Mineralization 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 2 (3%) 6 (10%) 11 (19%)
Alveolus, Emphysema 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolus, Hyperplasia, Macrophage 10 (17%) 53 (91%) 5 (100%) 57 (98%) 5 (100%)
Alveolus, Proteinosis 1 (2%) 41 (71%) 3 (60%) 56 (97%) 5 (100%)
Bronchus, Hyperplasia, Lymphoid 10 (17%) 1 (20%) 14 (24%) 4 (80%)
Interstitium, Infiltration Cellular 19 (33%) 3 (60%) 35 (60%) 5 (100%) 43 (74%) 5 (100%)
Nose (58) (5) (58) (5) (57) (5)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 13 (22%) 12 (21%) 18 (32%) 3 (60%)
Thrombosis 3 (5%) 3 (5%) 4 (7%)
Nasolacrimal Duct, Inflammation 3 (5%)
Olfactory Epithelium, Atrophy 2 (3%) 1 (2%) 9 (16%) 1 (20%)
Olfactory Epithelium, Mineralization, Focal 1 (2%) 3 (5%)
Respiratory Epithelium, Hyperplasia 1 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (4) (3)
Cataract 1 (25%) 2 (50%)
Inflammation 1 (25%)
Phthisis Bulbi 1 (25%)
Anterior Chamber, Hemorrhage, Chronic 1 (25%)
Iris, Inflammation 1 (25%)
Retina, Degeneration 3 (75%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (57) (5) (58) (5) (58) (5)
Cyst 1 (2%) 2 (3%) 2 (3%)
Embolus 1 (2%)
Hydronephrosis 1 (2%)
Infarct 1 (2%) 1 (2%)
Inflammation 1 (2%)
Mineralization 1 (2%) 1 (2%)
Nephropathy 56 (98%) 58 (100%) 58 (100%)
Cortex, Infarct 2 (3%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Pigmentation 20 (35%) 35 (60%) 35 (60%)
Urethra (1)
Calculus Micro Observation Only 1 (100%)
Urinary Bladder (58) (3) (58) (4) (58) (5)
Calculus Gross Observation 4 (7%) 2 (3%)
Calculus Micro Observation Only 5 (9%) 2 (67%) 3 (5%) 4 (100%) 3 (5%) 5 (100%)
Congestion 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
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