TDMS Study 05107-05 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
NICKEL SUBSULFIDE
NTP Experiment-Test: 05107-05 Report: PEIRPT05
Study Type: CHRONIC Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 12035722
Lock Date: 09/30/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 10 60 10 60 10
Scheduled Sacrifice 2 5 2 5 2 5
Early Deaths
Moribund Sacrifice 24 27 23
Natural Death 4 1 1
Accidently Killed 1
Survivors
Terminal Sacrifice 25 25 28
Animals Examined Microscopically 58 5 58 5 58 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (58) (58) (58) (1)
Histiocytic Sarcoma 1 (2%)
Mesentery (1) (2)
Histiocytic Sarcoma 1 (50%)
Pancreas (58) (57) (58)
Histiocytic Sarcoma 1 (2%)
Stomach, Forestomach (58) (58) (58)
Stomach, Glandular (58) (58) (58)
Tooth (1) (1)
Gingiva, Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (58) (58) (58)
Schwannoma NOS 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (58) (58) (58)
Adrenal Medulla (58) (56) (58)
Histiocytic Sarcoma 1 (2%)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Benign 2 (3%) 6 (11%) 12 (21%)
Bilateral, Pheochromocytoma Benign 1 (2%) 24 (41%)
Islets, Pancreatic (58) (58) (58)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%) 1 (2%)
Parathyroid Gland (52) (55) (54)
Page 2
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pituitary Gland (57) (58) (58)
Pars Distalis, Adenoma 24 (42%) 31 (53%) 17 (29%)
Thyroid Gland (56) (58) (57)
C-Cell, Adenoma 3 (5%) 4 (7%) 4 (7%)
C-Cell, Carcinoma 3 (5%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (1)
Mediastinum, Squamous Cell Carcinoma,
Metastatic, Lung 1 (50%)
Thoracic, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (100%)
Thoracic, Squamous Cell Carcinoma,
Metastatic, Lung 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (57) (57) (57)
Adenoma 2 (4%) 1 (2%)
Carcinoma 2 (4%) 3 (5%) 3 (5%)
Ovary (58) (1) (58) (1) (58) (1)
Cystadenoma 1 (2%)
Granulosa Cell Tumor Benign 2 (3%)
Granulosa-Theca Tumor Benign 1 (2%)
Histiocytic Sarcoma 1 (2%)
Uterus (58) (58) (58)
Adenoma 1 (2%)
Polyp Stromal 2 (3%) 1 (2%) 3 (5%)
Sarcoma Stromal 1 (2%)
Vagina (1) (2)
Polyp 1 (50%)
Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (58) (58) (58)
Histiocytic Sarcoma 1 (2%)
Lymph Node (5) (3) (10)
Iliac, Histiocytic Sarcoma 1 (10%)
Renal, Histiocytic Sarcoma 1 (10%)
Lymph Node, Bronchial (55) (5) (54) (5) (55) (5)
Histiocytic Sarcoma 1 (2%)
Page 3
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Lymph Node, Mandibular (49) (53) (56)
Lymph Node, Mesenteric (57) (58) (57)
Lymph Node, Mediastinal (51) (5) (55) (4) (52) (5)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Histiocytic Sarcoma 1 (2%)
Spleen (58) (58) (58)
Histiocytic Sarcoma 1 (2%)
Thymus (54) (56) (55)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (58) (58)
Adenoma 1 (2%)
Carcinoma 1 (2%) 3 (5%)
Fibroadenoma 22 (38%) 11 (19%) 10 (17%)
Skin (58) (58) (58)
Fibrosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Keratoacanthoma 1 (2%)
Pinna, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (58) (58) (58)
Squamous Cell Carcinoma, Metastatic, Tooth 1 (2%)
Skeletal Muscle (1)
Squamous Cell Carcinoma, Metastatic, Tooth 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (58) (58) (58)
Astrocytoma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (58) (5) (58) (5) (58) (5)
Adenoma 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (2%) 5 (9%) 5 (9%)
Alveolar/Bronchiolar Carcinoma 3 (5%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Histiocytic Sarcoma 1 (2%)
Page 4
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Squamous Cell Carcinoma 1 (2%)
Nose (58) (5) (58) (5) (57) (5)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (5) (58) (5) (58) (5)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Histiocytic Sarcoma 1 (2%)
Nephroblastoma 1 (2%)
Urinary Bladder (58) (58) (58)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(58) *(5) *(58) *(5) *(58) *(5)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 19 (33%) 18 (31%) 22 (38%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 53 52
Total Primary Neoplasms 85 102 113
Total Animals with Benign Neoplasms 37 46 48
Total Benign Neoplasms 58 65 80
Total Animals with Malignant Neoplasms 25 31 29
Total Malignant Neoplasms 26 34 33
Total Animals with Metastatic Neoplasms 2 1
Total Metastatic Neoplasm 4 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 3
Total Uncertain Neoplasms 1 3
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 10 60 10 60 10
Scheduled Sacrifice 5 5 5 5 5 5
Early Deaths
Moribund Sacrifice 35 28 33
Natural Death 5 4 2
Survivors
Terminal Sacrifice 13 21 18
Animals Examined Microscopically 58 5 58 5 58 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (56) (56) (58)
Intestine Large, Rectum (51) (50) (57)
Fibrosarcoma, Metastatic, Testes 1 (2%)
Intestine Small, Duodenum (57) (57) (58)
Adenocarcinoma 1 (2%)
Intestine Small, Jejunum (56) (56) (57)
Intestine Small, Ileum (56) (56) (57)
Liver (58) (58) (58)
Hepatocellular Adenoma 4 (7%) 1 (2%) 3 (5%)
Histiocytic Sarcoma 1 (2%)
Mesentery (1) (1) (1)
Pancreas (58) (58) (58)
Adenoma 1 (2%) 1 (2%)
Pharynx (1)
Squamous Cell Papilloma 1 (100%)
Salivary Glands (58) (57) (58)
Stomach, Forestomach (58) (58) (58)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (58) (58) (58)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
Tooth (1) (1) (1)
Gingiva, Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (58) (58) (58)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (57) (58) (58)
Adrenal Medulla (58) (57) (58)
Pheochromocytoma Malignant 2 (4%) 6 (10%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 12 (21%) 23 (40%) 14 (24%)
Bilateral, Pheochromocytoma Malignant 5 (9%)
Bilateral, Pheochromocytoma Benign 1 (2%) 7 (12%) 23 (40%)
Islets, Pancreatic (58) (58) (58)
Adenoma 2 (3%) 4 (7%) 4 (7%)
Carcinoma 1 (2%) 2 (3%)
Parathyroid Gland (55) (55) (56)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (58) (57) (58)
Pars Distalis, Adenoma 20 (34%) 17 (30%) 17 (29%)
Thyroid Gland (57) (58) (58)
C-Cell, Adenoma 4 (7%) 2 (3%) 9 (16%)
C-Cell, Carcinoma 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (1) (1)
Abdominal, Fibrosarcoma 1 (100%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (100%)
Thoracic, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (100%)
Thoracic, Fibrosarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (58) (58) (58) (1)
Adenoma 1 (2%) 2 (3%)
Carcinoma 2 (3%)
Prostate (58) (58) (58)
Seminal Vesicle (57) (58) (57)
Testes (58) (58) (58)
Bilateral, Interstitial Cell, Adenoma 28 (48%) 30 (52%) 15 (26%)
Interstitial Cell, Adenoma 15 (26%) 16 (28%) 22 (38%)
Tunic, Fibrosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (58) (57) (58)
Lymph Node (5) (16) (6)
Iliac, Fibrosarcoma, Metastatic, Testes 1 (17%)
Lymph Node, Bronchial (57) (4) (56) (5) (57) (5)
Lymph Node, Mandibular (55) (56) (54)
Lymph Node, Mesenteric (58) (58) (58)
Lymph Node, Mediastinal (53) (5) (54) (5) (53) (5)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Histiocytic Sarcoma 1 (2%)
Spleen (58) (58) (58)
Thymus (55) (53) (53)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (53) (53) (48)
Adenoma 1 (2%)
Fibroadenoma 1 (2%)
Skin (58) (58) (58)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Fibroma 2 (3%) 2 (3%) 3 (5%)
Keratoacanthoma 4 (7%) 4 (7%) 1 (2%)
Squamous Cell Papilloma 1 (2%)
Nose, Squamous Cell Papilloma 1 (2%)
Pinna, Keratoacanthoma 1 (2%)
Pinna, Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%)
Tail, Fibroma 1 (2%)
Tail, Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (58) (57) (58)
Cranium, Osteosarcoma 1 (2%)
Maxilla, Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (58) (58) (58)
Astrocytoma NOS 1 (2%)
Oligodendroglioma NOS 1 (2%)
Spinal Cord (1) (1)
Astrocytoma Benign 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (58) (5) (58) (5) (58) (5)
Alveolar/Bronchiolar Adenoma 3 (5%) 5 (9%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 3 (5%) 7 (12%)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Chordoma, Metastatic, Tissue NOS 1 (2%)
Fibrosarcoma, Metastatic, Testes 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Nose (58) (5) (58) (5) (57) (5)
Trachea (58) (58) (57)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (57) (5) (58) (5) (58) (5)
Urinary Bladder (58) (3) (58) (4) (58) (5)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(58) *(5) *(58) *(5) *(58) *(5)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 28 (48%) 32 (55%) 36 (62%)
Mesothelioma NOS 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05107-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:11:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.15 0.15 1.0 1.0
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 56 53 56
Total Primary Neoplasms 141 158 183
Total Animals with Benign Neoplasms 53 53 52
Total Benign Neoplasms 103 115 122
Total Animals with Malignant Neoplasms 33 37 46
Total Malignant Neoplasms 37 41 60
Total Animals with Metastatic Neoplasms 2 2 4
Total Metastatic Neoplasm 3 4 6
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 2 1
Total Uncertain Neoplasms 9 2 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------