TDMS Study 05107-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: LITRI NICKEL SUBSULFIDE DATE: 05/19/95
EXPERIMENT: 05107 TEST: 05 TIME: 22:26:16
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: Y01ES30108 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C61654
PATHOLOGIST: F. HAHN CAS: 12035722
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: LITRI NICKEL SUBSULFIDE DATE: 05/19/95
EXPERIMENT: 05107 TEST: 05 TIME: 22:26:16
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: Y01ES30108 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C61654
PATHOLOGIST: F. HAHN CAS: 12035722
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0MG/M3 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 40 CENSORED DEATHS 7 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 257 361 373 521 537 539 542 553 559 559 |
| 565 565 572 573 574 578 594 596 599 608 |
| 615 624 634 635 639 651 657 664 671 678 |
| 683 691 696 699 701 705 706 713 715 728 |
| CENSORED DEATHS |
| 199 199 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.0MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 199 199 199 199 199 199 199 199 199 199 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.15 MG/M3 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 32 CENSORED DEATHS 7 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 398 455 538 549 552 563 569 570 594 594 |
| 595 599 599 601 608 623 623 624 638 638 |
| 639 639 642 650 661 690 695 700 713 717 |
| 718 727 |
| CENSORED DEATHS |
| 199 199 458 458 458 458 458 |
| |
==================================================================================
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.15 LUNG TOX |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 199 199 199 199 199 199 199 199 199 199 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 35 CENSORED DEATHS 7 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 408 424 509 527 552 559 560 564 564 577 |
| 578 584 590 594 595 621 621 623 629 642 |
| 643 648 650 663 663 678 703 703 703 707 |
| 711 716 723 726 731 |
| CENSORED DEATHS |
| 199 199 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 LUNG TOX |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 199 199 199 199 199 199 199 199 199 199 |
| |
==================================================================================
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0MG/M3 | 100.0 100.0 98.3 96.6 94.8 94.8 87.2 64.5 47.4 24.7 |
| | |
| | |
|0.0MG/M3LUN| 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
|0.15 | 100.0 100.0 100.0 100.0 98.3 96.6 94.7 73.8 53.0 39.8 |
|MG/M3 | |
| | |
|0.15 | 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|LUNG TOX | |
| | |
|1.0 | 100.0 100.0 100.0 100.0 96.6 96.6 92.8 71.9 53.0 34.1 |
|MG/M3 | |
| | |
|1.0 | 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|LUNG TOX | |
| | |
==================================================================================
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0MG/M3 0.0MG/M3LUNG 0.15 0.15 1.0 1.0 |
| TOX MG/M3 LUNG TOX MG/M3 LUNG TOX |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 24.7% 0.0% 39.8% 0.0% 34.1% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.579N ----- P=0.123N ----- P=0.260N ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 603.3 . 616.3 . 619.7 . |
|NATURAL DEATHS (C) | (15.8) ( . ) (12.9) ( . ) (13.6) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 605.8 199.0 630.0 199.0 626.2 199.0 |
|(STANDARD ERROR) | (17.1) ( 0.0) (16.1) ( 0.0) (16.2) ( 0.0) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0MG/M3 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 28 CENSORED DEATHS 7 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 263 369 377 477 477 500 513 538 563 574 |
| 574 613 640 640 640 642 657 664 665 665 |
| 667 677 678 696 716 717 721 721 |
| CENSORED DEATHS |
| 200 200 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.0MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 200 200 200 200 200 200 200 200 200 200 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.15 MG/M3 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 28 CENSORED DEATHS 7 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 452 482 482 538 566 590 594 594 609 609 |
| 612 620 620 622 635 636 640 642 649 653 |
| 678 681 695 699 706 718 721 727 |
| CENSORED DEATHS |
| 200 200 459 459 459 459 459 |
| |
==================================================================================
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.15 LUNG TOX |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 200 200 200 200 200 200 200 200 200 200 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 24 CENSORED DEATHS 8 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 444 501 526 538 563 582 590 594 602 615 |
| 622 633 634 634 635 641 641 643 663 673 |
| 706 709 712 726 |
| CENSORED DEATHS |
| 200 200 281 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 LUNG TOX |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 200 200 200 200 200 200 200 200 200 200 |
| |
==================================================================================
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0MG/M3 | 100.0 100.0 98.3 98.3 94.8 91.0 85.3 79.7 62.6 47.4 |
| | |
| | |
|0.0MG/M3LUN| 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
|0.15 | 100.0 100.0 100.0 100.0 100.0 94.5 92.6 85.0 62.4 47.2 |
|MG/M3 | |
| | |
|0.15 | 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|LUNG TOX | |
| | |
|1.0 | 100.0 100.0 100.0 100.0 100.0 98.2 92.5 82.8 63.6 53.9 |
|MG/M3 | |
| | |
|1.0 | 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|LUNG TOX | |
| | |
==================================================================================
NICKEL SUBSULFIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0MG/M3 0.0MG/M3LUNG 0.15 0.15 1.0 1.0 |
| TOX MG/M3 LUNG TOX MG/M3 LUNG TOX |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 47.4% 0.0% 47.2% 0.0% 53.9% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.563N ----- P=1.000N ----- P=0.633N ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 594.4 . 623.9 . 617.8 . |
|NATURAL DEATHS (C) | (22.3) ( . ) (13.6) ( . ) (14.1) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 626.1 200.0 639.8 200.0 636.9 200.0 |
|(STANDARD ERROR) | (18.2) ( 0.0) (15.9) ( 0.0) (17.0) ( 0.0) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NICKEL SUBSULFIDE
KAPLAN-MEIER SURVIVAL CURVES
0.0MG/M3 = 1
0.0MG/M3LUNG TOX = 2
0.15 MG/M3 = 3
0.15 LUNG TOX = 4
1.0 MG/M3 = 5
1.0 LUNG TOX = 6
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
100 + 1 1 3 5
| 1 1 1 3 5 5 3 5 3
| 1 5 153 3
| 151 5
90 + 113533
| 1155
| 11 3 3
| 11 5
80 + 55 33
| 11 5 5
| 33
| 11 5 3 3
P 70 + 1 1
E | 11 33 3
R | 11 5 5
C | 11
E 60 + 1 1155
N | 33 5
T | 113 3
| 11 3 5 3
S 50 + 11 1 5 335
U | 11 3 3
R | 11 33
V | 111 5533
I 40 + 11 53 3
V |
A | 11 5 5
L |
30 + 11
| 111
| 1 1
|
20 +
|
|
|
10 +
|
|
|
0 + 2
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 30 obs hidden.
NICKEL SUBSULFIDE
KAPLAN-MEIER SURVIVAL CURVES
0.0MG/M3 = 1
0.0MG/M3LUNG TOX = 2
0.15 MG/M3 = 3
0.15 LUNG TOX = 4
1.0 MG/M3 = 5
1.0 LUNG TOX = 6
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
100 + 1 1 5 3
| 1 11 5 3 3 5 5
| 1 1 53
| 3 3
90 + 1 1 1 3 5 3
| 1 1 5 5
| 1 1 353
| 11 533
80 + 1 13 5
| 1 1
|
| 3 35
P 70 + 31 1
E | 1 1
R | 333 5
C | 3 113 5
E 60 + 113 55
N | 13 1
T | 13515 5
| 3 3
S 50 + 33
U | 13 1
R |
V |
I 40 +
V |
A |
L |
30 +
|
|
|
20 +
|
|
|
10 +
|
|
|
0 + 2
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 36 obs hidden.