TDMS Study 05108-01 Pathology Tables
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
Facility: TSI Mason Research
Chemical CAS #: 58-33-3
Lock Date: 10/28/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 0| 7| 7| 4| 4| 4| 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 1| 1| 1| 2| 3| 3| 7| 5| 5| 3| 6| 5| 5| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2|
| 6| 7| 3| 2| 3| 6| 6| 3| 0| 0| 4| 2| 1| 0| 0| 7| 7| 7| 7| 1| 6| 6| 6| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Fatty Change, Diffuse | 3 2 |
Fatty Change, Focal | 1 2 |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous | 2 2 |
Mixed Cell Focus | |
Necrosis | |
Pigmentation | 3 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Mineralization | 1 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Angiectasis | 2 2 3 2 2 2 2 2 2|
Pars Distalis, Cyst | X |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 0| 7| 7| 4| 4| 4| 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 1| 1| 1| 2| 3| 3| 7| 5| 5| 3| 6| 5| 5| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2|
| 6| 7| 3| 2| 3| 6| 6| 3| 0| 0| 4| 2| 1| 0| 0| 7| 7| 7| 7| 1| 6| 6| 6| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 2 2 1 2 1 2 2 2 2 |
Pars Nervosa, Angiectasis | |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X|
__________________________________________________________________________|
Uterus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | 2 |
Metaplasia, Osseous | |
Cervix, Fibrosis | |
Cervix, Inflammation, Acute | |
Cervix, Pigmentation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + +|
Pancreatic, Angiectasis | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Infiltration Cellular, Histiocyte | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 2 |
Infarct | 3|
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + M + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 0| 7| 7| 4| 4| 4| 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 1| 1| 1| 2| 3| 3| 7| 5| 5| 3| 6| 5| 5| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2|
| 6| 7| 3| 2| 3| 6| 6| 3| 0| 0| 4| 2| 1| 0| 0| 7| 7| 7| 7| 1| 6| 6| 6| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + M + + + + + + + + + + +|
Galactocele | X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Alveolar Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + M + +|
Fungus | |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 1 2 2 2 1 2 1 1 1|
Pigmentation | 3 |
Artery, Inflammation, Chronic Active | 2 |
Cortex, Mineralization | 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 5| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 4| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 7| 1| 3| 3| 4| 3| 4| 3| 3| 3| 3| 3|
| 7| 4| 7| 7| 0| 7| 7| 7| 5| 2| 7| 7| 7| 3| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X|
Clear Cell Focus | X |
Fatty Change, Diffuse | |
Fatty Change, Focal | 1 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous | 1 1 2 1 |
Mixed Cell Focus | X X |
Necrosis | |
Pigmentation | |
__________________________________________________________________________|
Mesentery | |
Fat, Mineralization | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 1 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2 2 2 2 2 2 2 2|
Pars Distalis, Cyst | X X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 5| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 4| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 7| 1| 3| 3| 4| 3| 4| 3| 3| 3| 3| 3|
| 7| 4| 7| 7| 0| 7| 7| 7| 5| 2| 7| 7| 7| 3| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 3 3 1 3 2 2 2 1 2 |
Pars Nervosa, Angiectasis | 2 2 |
Pars Nervosa, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 2 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | |
Metaplasia, Osseous | 2 |
Cervix, Fibrosis | 2 |
Cervix, Inflammation, Acute | 2 |
Cervix, Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + |
Pancreatic, Angiectasis | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 |
Infarct | |
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + M + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 5| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 4| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 7| 1| 3| 3| 4| 3| 4| 3| 3| 3| 3| 3|
| 7| 4| 7| 7| 0| 7| 7| 7| 5| 2| 7| 7| 7| 3| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 1 1 1 2 1 1 2 2 1 2 2 2 2 2 1 1 1 1 1 1 2|
Pigmentation | |
Artery, Inflammation, Chronic Active | |
Cortex, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 2| 7| 3| 8| 5| 5| 5| | |
| 7| 7| 7| 9| 4| 7| 4| 1| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + A + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X | 28 |
Clear Cell Focus | | 2 |
Fatty Change, Diffuse | | 2 2.5|
Fatty Change, Focal | 2 | 5 1.4|
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation, Granulomatous | | 6 1.5|
Mixed Cell Focus | X | 3 |
Necrosis | 2 | 1 2.0|
Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Mineralization | | 1 1.0|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Duct, Metaplasia, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + M + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Necrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 2 2 2 2 | 29 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 2| 7| 3| 8| 5| 5| 5| | |
| 7| 7| 7| 9| 4| 7| 4| 1| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Angiectasis | 2 2 2 2 2 2 1 | 27 2.0|
Pars Distalis, Cyst | X X X | 7 |
Pars Distalis, Hyperplasia | 2 2 2 | 21 2.0|
Pars Nervosa, Angiectasis | 2 | 3 2.0|
Pars Nervosa, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + A + + + | 59 |
C-Cell, Hyperplasia | 1 2 1 | 10 1.6|
Follicle, Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + | 56 |
Hyperplasia | | 1 2.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Acute | | 1 2.0|
Metaplasia, Osseous | | 1 2.0|
Cervix, Fibrosis | | 1 2.0|
Cervix, Inflammation, Acute | | 1 2.0|
Cervix, Pigmentation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 5 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + | 12 |
Pancreatic, Angiectasis | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 2| 7| 3| 8| 5| 5| 5| | |
| 7| 7| 7| 9| 4| 7| 4| 1| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Infiltration Cellular, Histiocyte | | 2 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 2 2.5|
Hematopoietic Cell Proliferation | | 3 2.3|
Infarct | | 1 3.0|
Infiltration Cellular, Histiocyte | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 55 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
Galactocele | X X X X | 14 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Fungus | | 1 3.0|
Inflammation, Acute | | 2 3.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy | 1 1 2 1 1 2 1 1 1 | 52 1.3|
Pigmentation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 2| 7| 3| 8| 5| 5| 5| | |
| 7| 7| 7| 9| 4| 7| 4| 1| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Artery, Inflammation, Chronic Active | | 1 2.0|
Cortex, Mineralization | 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 9| 5| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 2| 5| 5|
| 6| 9| 7| 1| 0| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
8.3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Hyperkeratosis | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X|
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous | |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 1 2 2 2 2 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hemorrhage | |
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 9| 5| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 2| 5| 5|
| 6| 9| 7| 1| 0| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
8.3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 2 2 2 3 2 2 2 2 2 1 2 |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 2 2 2 3 2 3 2 2 2|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hemorrhage | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + M M + + + + + + + + + + + + + + M + + + + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 9| 5| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 2| 5| 5|
| 6| 9| 7| 1| 0| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
8.3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Edema | |
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Nephropathy | 1 1 1 2 2 1 2 1 1 2 3 2 3 1 1 2 2 2 4 1 1|
Cortex, Mineralization | 1 1|
Pelvis, Inflammation, Chronic Active | |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 5| 5| 5| 7| 7| 6| 5| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 7| 5| 3| 3| 9| 9| 9| 3| 3| 3| 6| 5| 1| 3| 3| 3| 3| 3| 3| 3| 5| 5|
| 6| 6| 6| 9| 0| 5| 5| 7| 7| 1| 6| 6| 2| 6| 1| 7| 5| 2| 6| 6| 6| 6| 4| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
8.3 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Erosion | |
Hyperkeratosis | 3 |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + A + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +|
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + A + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperkeratosis | 3 |
Hyperplasia, Basal Cell | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 1 2 2 2 2 2 1 2|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + A + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hemorrhage | 3 |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 5| 5| 5| 7| 7| 6| 5| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 7| 5| 3| 3| 9| 9| 9| 3| 3| 3| 6| 5| 1| 3| 3| 3| 3| 3| 3| 3| 5| 5|
| 6| 6| 6| 9| 0| 5| 5| 7| 7| 1| 6| 6| 2| 6| 1| 7| 5| 2| 6| 6| 6| 6| 4| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
8.3 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 2 2 3 2 2 1 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 3 2 2 2 2 2 2 |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + M + + A + + + + + + + + M + +|
Necrosis | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + A + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +|
Fibrosis | 3 |
Hemorrhage | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + A + + + + + + + + + + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + M + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 5| 5| 5| 7| 7| 6| 5| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 7| 5| 3| 3| 9| 9| 9| 3| 3| 3| 6| 5| 1| 3| 3| 3| 3| 3| 3| 3| 5| 5|
| 6| 6| 6| 9| 0| 5| 5| 7| 7| 1| 6| 6| 2| 6| 1| 7| 5| 2| 6| 6| 6| 6| 4| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
8.3 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Edema | 2 |
Infiltration Cellular, Histiocyte | 2 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Acute | 4 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 |
Nephropathy | 1 1 1 1 1 1 2 3 2 3 2 1 2 1 1 1 1 2 2 1 4 1 |
Cortex, Mineralization | 1 1|
Pelvis, Inflammation, Chronic Active | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 0| 9| 5| 3| 3| 3| 3| 5| | |
| 5| 6| 4| 2| 1| 6| 6| 5| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
8.3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Erosion | | 1 3.0|
Hyperkeratosis | | 1 3.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Basophilic Focus | X X X X | 32 |
Hepatodiaphragmatic Nodule | X | 6 |
Inflammation, Granulomatous | | 1 1.0|
Mixed Cell Focus | | 1 |
Bile Duct, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Acinus, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Hyperkeratosis | | 2 2.5|
Hyperplasia, Basal Cell | | 3 1.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 2 | 29 1.9|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Accessory Adrenal Cortical Nodule | X | 2 |
Hemorrhage | | 1 3.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 0| 9| 5| 3| 3| 3| 3| 5| | |
| 5| 6| 4| 2| 1| 6| 6| 5| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
8.3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | 1 | 4 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | 3 3 2 | 24 2.1|
Pars Distalis, Cyst | X | 7 |
Pars Distalis, Hyperplasia | 2 2 2 2 | 20 2.2|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | 1 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + | 55 |
Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 5 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Fibrosis | | 2 2.5|
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 54 |
Galactocele | X X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 0| 9| 5| 3| 3| 3| 3| 5| | |
| 5| 6| 4| 2| 1| 6| 6| 5| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
8.3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Edema | | 1 2.0|
Infiltration Cellular, Histiocyte | | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Fungus | | 1 2.0|
Inflammation, Acute | | 3 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Mineralization | | 2 1.5|
Nephropathy | 1 3 2 1 2 2 1 1 1 | 52 1.6|
Cortex, Mineralization | 1 1 | 6 1.0|
Pelvis, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 6| 7| 3| 3| 3| 5| 5| 3| 3| 3| 0| 5| 3| 3| 3| 5| 5| 3| 3| 3| 8| 4|
| 5| 5| 5| 6| 5| 5| 5| 5| 1| 1| 5| 5| 5| 4| 1| 4| 4| 4| 7| 0| 4| 4| 4| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
16.6 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X |
Fibrosis | 2 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Granulomatous | |
Mixed Cell Focus | X |
Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 1 |
Necrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2 2 2 2 2 2|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 3 3 3 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 6| 7| 3| 3| 3| 5| 5| 3| 3| 3| 0| 5| 3| 3| 3| 5| 5| 3| 3| 3| 8| 4|
| 5| 5| 5| 6| 5| 5| 5| 5| 1| 1| 5| 5| 5| 4| 1| 4| 4| 4| 7| 0| 4| 4| 4| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
16.6 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + M + + M +|
__________________________________________________________________________|
Lymph Node | + + +|
Pancreatic, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hemorrhage | 2 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 6| 7| 3| 3| 3| 5| 5| 3| 3| 3| 0| 5| 3| 3| 3| 5| 5| 3| 3| 3| 8| 4|
| 5| 5| 5| 6| 5| 5| 5| 5| 1| 1| 5| 5| 5| 4| 1| 4| 4| 4| 7| 0| 4| 4| 4| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
16.6 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Edema | |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + M +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + +|
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Mineralization | |
Nephropathy | 2 1 1 3 1 1 2 2 1 2 1 2 1 1 2 3 1 1 2 1 1 2 2|
Bilateral, Papilla, Necrosis | |
Cortex, Mineralization | 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 3| 7| 7| 7| 7| 4| 7| 6| 6| 5| 4| 7| 7| 7| 6| 5| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 4| 5| 6| 3| 3| 3| 3| 5| 3| 8| 4| 5| 5| 3| 3| 3| 7| 7| 3| 3| 1| 7| 5|
| 4| 4| 7| 0| 0| 4| 4| 4| 4| 1| 5| 9| 4| 0| 1| 5| 5| 5| 5| 6| 4| 4| 4| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
16.6 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + A + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + A + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + A + + + + + + + + A + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + A + + + + + + + + A A +|
Necrosis | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + A + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + A + + + + + + + + A A +|
Necrosis | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X|
Fibrosis | 2 |
Hepatodiaphragmatic Nodule | X|
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | X |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + A + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | |
Necrosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + A + A + + + + + + + + A + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + A + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + A + + + + + + + + + A +|
Pars Distalis, Angiectasis | 2 2 2 2 2 2 2 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + A + + + + + + + + + + A + + + + + + + + + A +|
C-Cell, Hyperplasia | 2 1 1 1 3 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 3| 7| 7| 7| 7| 4| 7| 6| 6| 5| 4| 7| 7| 7| 6| 5| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 4| 5| 6| 3| 3| 3| 3| 5| 3| 8| 4| 5| 5| 3| 3| 3| 7| 7| 3| 3| 1| 7| 5|
| 4| 4| 7| 0| 0| 4| 4| 4| 4| 1| 5| 9| 4| 0| 1| 5| 5| 5| 5| 6| 4| 4| 4| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
16.6 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X|
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Pancreatic, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | |
Hyperplasia | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + M + + + + + + + + + + M|
Fibrosis | 2 |
Epithelial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 3| 7| 7| 7| 7| 4| 7| 6| 6| 5| 4| 7| 7| 7| 6| 5| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 4| 5| 6| 3| 3| 3| 3| 5| 3| 8| 4| 5| 5| 3| 3| 3| 7| 7| 3| 3| 1| 7| 5|
| 4| 4| 7| 0| 0| 4| 4| 4| 4| 1| 5| 9| 4| 0| 1| 5| 5| 5| 5| 6| 4| 4| 4| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
16.6 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Edema | |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +|
Inflammation, Acute | |
Mineralization | 1 |
Nephropathy | 2 3 1 2 3 1 2 2 2 1 2 1 2 1 1 1 3 2 2 2 |
Bilateral, Papilla, Necrosis | |
Cortex, Mineralization | 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + A + + + + + + + + + A +|
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 6| 4| 3| | |
DAY ON TEST | 3| 3| 5| 5| 5| 3| 3| 8| 5| 0| | |
| 4| 4| 2| 0| 0| 4| 4| 5| 0| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
16.6 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Hyperkeratosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + A | 53 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + A | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + | 54 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + A | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + A | 53 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X X X | 23 |
Fibrosis | | 2 2.0|
Hepatodiaphragmatic Nodule | X | 5 |
Inflammation, Granulomatous | 2 | 2 1.5|
Mixed Cell Focus | | 2 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Duct, Metaplasia, Squamous | | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperplasia, Basal Cell | | 1 1.0|
Necrosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + | 54 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 2 1 | 28 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Accessory Adrenal Cortical Nodule | | 1 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 3 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + + + + + + | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | 2 2 2 | 20 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 6| 4| 3| | |
DAY ON TEST | 3| 3| 5| 5| 5| 3| 3| 8| 5| 0| | |
| 4| 4| 2| 0| 0| 4| 4| 5| 0| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
16.6 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia | 2 3 2 | 18 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + A + + + + + + | 55 |
C-Cell, Hyperplasia | | 8 1.5|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Oviduct | + | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Decidual Reaction | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
Pancreatic, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + | 59 |
Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
Fibrosis | | 1 2.0|
Epithelial Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + | 59 |
Galactocele | X X | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 6| 4| 3| | |
DAY ON TEST | 3| 3| 5| 5| 5| 3| 3| 8| 5| 0| | |
| 4| 4| 2| 0| 0| 4| 4| 5| 0| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
16.6 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Edema | 2 1 | 2 1.5|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Inflammation, Acute | | 2 1.5|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Inflammation, Acute | 1 1 | 6 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Lens, Cataract | 3 | 1 3.0|
Retina, Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Inflammation, Acute | 2 | 1 2.0|
Mineralization | | 1 1.0|
Nephropathy | 2 1 1 1 2 2 2 | 50 1.7|
Bilateral, Papilla, Necrosis | 3 | 1 3.0|
Cortex, Mineralization | 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + | 56 |
Hemorrhage | 3 | 1 3.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 3| 7| 6| 5| 4| 4| 7| 7| 4| 2| 0| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 3| 6| 2| 5| 9| 3| 5| 7| 5| 2| 3| 3| 5| 5| 3| 3| 3| 8| 9| 7| 3| 3| 9| 5| 5|
| 4| 6| 9| 0| 3| 1| 1| 5| 1| 1| 1| 1| 0| 9| 0| 1| 1| 9| 1| 0| 1| 1| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
33.3 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + A A + + + A + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A A + + + + + + + + A A + + + A + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A A + A + + + + + + A A + + + A A + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A A + A + + + + + + + A + + + A + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A A + A + + + + + + A A + + + A A + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + A + + + + + + A A + + + A A + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | |
Fatty Change, Focal | 2 |
Hepatodiaphragmatic Nodule | X X X X X X |
Inflammation, Granulomatous | |
Mixed Cell Focus | X X |
Pigmentation | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Basal Cell | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + A + + + A + + + A + +|
Hyperplasia | 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 1 2 2 2 2 2 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | |
Pars Distalis, Angiectasis | 2 2 2 3 2 1 2 |
Pars Distalis, Hyperplasia | 1 2 2 2 2 3 1|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 3| 7| 6| 5| 4| 4| 7| 7| 4| 2| 0| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 3| 6| 2| 5| 9| 3| 5| 7| 5| 2| 3| 3| 5| 5| 3| 3| 3| 8| 9| 7| 3| 3| 9| 5| 5|
| 4| 6| 9| 0| 3| 1| 1| 5| 1| 1| 1| 1| 0| 9| 0| 1| 1| 9| 1| 0| 1| 1| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
33.3 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Hyperplasia | 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + A + + + + + +|
C-Cell, Hyperplasia | 1 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
Dilatation | |
Inflammation, Acute | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + A + + + + + + + + + +|
Cyst | |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Angiectasis | 3 |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Infarct | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + A + + + + + + + + + +|
Epithelial Cell, Ectopic Parathyroid | |
Gland | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + M + + + + + + + + M +|
Galactocele | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 3| 7| 6| 5| 4| 4| 7| 7| 4| 2| 0| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 3| 6| 2| 5| 9| 3| 5| 7| 5| 2| 3| 3| 5| 5| 3| 3| 3| 8| 9| 7| 3| 3| 9| 5| 5|
| 4| 6| 9| 0| 3| 1| 1| 5| 1| 1| 1| 1| 0| 9| 0| 1| 1| 9| 1| 0| 1| 1| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
33.3 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 1 1 1 1 1 2 2 1 2 2 1 1 1 2 1 2 1|
Cortex, Mineralization | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 5| 5| 0| 7| 7| 4| 4| 3| 7| 7| 7| 5| 3| 7| 7| 4| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 2| 6| 5| 8| 3| 0| 5| 4| 1| 3| 3| 3| 5| 9| 3| 3| 5| 4| 7|
| 1| 1| 1| 1| 1| 1| 9| 2| 0| 3| 1| 2| 0| 1| 1| 4| 4| 5| 2| 3| 4| 4| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
33.3 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + A + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A A + A + A A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A A + A + A M + + + + A + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A A + A + A M + + + + A + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A A + A + M M + + + + A + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A A + A + A M + + + + A + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A A + A + A M + M + + A + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + A + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X|
Clear Cell Focus | |
Fatty Change, Focal | |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | X X X |
Pigmentation | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + M M + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + A + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + + + M M + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A A + + + M M + + + + A + + + + +|
Hyperplasia | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + A + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 1 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + A + + + + M + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + A + + + + M + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + A + M M + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + A + + + + M + + + M + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + A + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | X |
Pars Distalis, Angiectasis | 2 2 2 2 1 2 |
Pars Distalis, Hyperplasia | 3 1 2 2 3 3 2 2|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 5| 5| 0| 7| 7| 4| 4| 3| 7| 7| 7| 5| 3| 7| 7| 4| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 2| 6| 5| 8| 3| 0| 5| 4| 1| 3| 3| 3| 5| 9| 3| 3| 5| 4| 7|
| 1| 1| 1| 1| 1| 1| 9| 2| 0| 3| 1| 2| 0| 1| 1| 4| 4| 5| 2| 3| 4| 4| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
33.3 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + A + + + + + M + + + + A + + + A +|
C-Cell, Hyperplasia | 1 2 1 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + A + + + + M + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + A + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + A + + + + M + + + + + + + + + +|
Cyst | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Angiectasis | |
Mediastinal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + A + + + M M + + + + A + + + + +|
Hematopoietic Cell Proliferation | 3|
Infarct | |
__________________________________________________________________________|
Thymus | + + + + + + + + M A + + + + + + + + + + + M + + +|
Epithelial Cell, Ectopic Parathyroid | |
Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + A + + + A M + + + + + + + + + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + A + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + M + + + + + + + + + + + + + + +|
Degeneration | 2 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 5| 5| 0| 7| 7| 4| 4| 3| 7| 7| 7| 5| 3| 7| 7| 4| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 2| 6| 5| 8| 3| 0| 5| 4| 1| 3| 3| 3| 5| 9| 3| 3| 5| 4| 7|
| 1| 1| 1| 1| 1| 1| 9| 2| 0| 3| 1| 2| 0| 1| 1| 4| 4| 5| 2| 3| 4| 4| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
33.3 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + M + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Lens, Cataract | 2|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + A + + + + M + + + + A + + + + +|
Nephropathy | 1 2 2 2 2 1 1 2 1 1 1 2 3 1 2 2 |
Cortex, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A A + A + A M + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 2| 0| 7| 7| 6| 5| 4| | |
DAY ON TEST | 3| 3| 9| 5| 2| 3| 3| 4| 8| 5| | |
| 4| 4| 9| 9| 9| 2| 4| 0| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
33.3 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Basophilic Focus | X X X | 20 |
Clear Cell Focus | X | 1 |
Fatty Change, Focal | | 1 2.0|
Hepatodiaphragmatic Nodule | | 10 |
Inflammation, Granulomatous | | 1 1.0|
Mixed Cell Focus | X X | 7 |
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 56 |
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Duct, Metaplasia, Squamous | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 57 |
Hyperkeratosis | 2 | 1 2.0|
Hyperplasia, Basal Cell | 2 | 2 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 51 |
Hyperplasia | | 1 1.0|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Cardiomyopathy | 2 2 1 2 2 | 27 1.9|
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 2| 0| 7| 7| 6| 5| 4| | |
DAY ON TEST | 3| 3| 9| 5| 2| 3| 3| 4| 8| 5| | |
| 4| 4| 9| 9| 9| 2| 4| 0| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
33.3 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + M + + | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Craniopharyngeal Duct, Cyst | | 1 |
Pars Distalis, Angiectasis | 2 2 3 | 16 2.0|
Pars Distalis, Hyperplasia | 3 2 | 17 2.1|
Pars Intermedia, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 54 |
C-Cell, Hyperplasia | 1 | 7 1.1|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 57 |
Dilatation | | 1 3.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 57 |
Cyst | X | 1 |
Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 5 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
Mediastinal, Angiectasis | | 1 3.0|
Mediastinal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 56 |
Hematopoietic Cell Proliferation | | 1 3.0|
Infarct | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 55 |
Epithelial Cell, Ectopic Parathyroid | | |
Gland | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 2| 0| 7| 7| 6| 5| 4| | |
DAY ON TEST | 3| 3| 9| 5| 2| 3| 3| 4| 8| 5| | |
| 4| 4| 9| 9| 9| 2| 4| 0| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
33.3 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + | 52 |
Galactocele | X | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Inflammation, Acute | 1 | 7 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Lens, Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 57 |
Nephropathy | 1 2 1 1 2 3 | 41 1.5|
Cortex, Mineralization | 1 | 4 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 4| 4| 7| 6| 6| 4| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 1| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 7| 0| 6| 6| 3| 8| 4| 6| 6| 3| 3| 3| 8| 8| 3| 3| 3| 8| 7| 3| 0| 9| 7| 6|
| 0| 1| 2| 3| 2| 0| 7| 1| 3| 2| 0| 0| 0| 4| 4| 0| 0| 0| 6| 0| 0| 3| 7| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X 1 X X X X |
Clear Cell Focus | X X X X |
Degeneration, Cystic | 2 1 2 |
Eosinophilic Focus | |
Fatty Change, Diffuse | 1 1 1 1 1|
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | |
Leukocytosis | |
Mixed Cell Focus | X X X |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 1 1 2 2 2 1 2 1 2 1 2 2 1 1 2 1 2|
__________________________________________________________________________|
Mesentery | + |
Fat, Mineralization | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia | 3 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 |
Hyperplasia, Basal Cell | 1 2 |
Necrosis | 3 |
Ulcer | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | |
Mineralization | 2 |
__________________________________________________________________________|
Tongue | + |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 3 2 3 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 4| 4| 7| 6| 6| 4| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 1| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 7| 0| 6| 6| 3| 8| 4| 6| 6| 3| 3| 3| 8| 8| 3| 3| 3| 8| 7| 3| 0| 9| 7| 6|
| 0| 1| 2| 3| 2| 0| 7| 1| 3| 2| 0| 0| 0| 4| 4| 0| 0| 0| 6| 0| 0| 3| 7| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1 2 1 2 |
Bilateral, Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + M + + + + +|
Hyperplasia | 3 |
Bilateral, Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 3 2 |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 1 1 2 2 2 3 2 2 3 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
C-Cell, Hyperplasia | 2 1 1 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2|
Seminiferous Tubule, Atrophy | 3 1 3 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Angiectasis | |
Pancreatic, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 4| 4| 7| 6| 6| 4| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 1| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 7| 0| 6| 6| 3| 8| 4| 6| 6| 3| 3| 3| 8| 8| 3| 3| 3| 8| 7| 3| 0| 9| 7| 6|
| 0| 1| 2| 3| 2| 0| 7| 1| 3| 2| 0| 0| 0| 4| 4| 0| 0| 0| 6| 0| 0| 3| 7| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 |
Infarct | 4 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + M M + + + M + + + M + +|
Cyst | X |
Epithelial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Mineralization | 1 |
Thrombosis | |
__________________________________________________________________________|
Peripheral Nerve | + |
Degeneration | 1 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 |
Infiltration Cellular, Histiocyte | 2 2 |
Inflammation, Acute | 2 |
Alveolar Epithelium, Hyperplasia | 2 3 |
Bronchiole, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Hyperkeratosis | 3 |
Inflammation, Acute | 3 1 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 4| 4| 7| 6| 6| 4| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 1| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 7| 0| 6| 6| 3| 8| 4| 6| 6| 3| 3| 3| 8| 8| 3| 3| 3| 8| 7| 3| 0| 9| 7| 6|
| 0| 1| 2| 3| 2| 0| 7| 1| 3| 2| 0| 0| 0| 4| 4| 0| 0| 0| 6| 0| 0| 3| 7| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Developmental Malformation | |
Mineralization | 1 |
Nephropathy | 3 4 2 2 2 2 3 3 2 2 3 3 3 3 2 3 3 3 2 3 3 4 3 2|
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Pelvis, Transitional Epithelium, | |
Inflammation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 6| 4| 4|
DAY ON TEST | 3| 1| 8| 7| 9| 3| 3| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 8| 7| 6| 6|
| 0| 6| 6| 3| 5| 0| 0| 2| 3| 2| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 0| 6| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X 1 X X 1 X X X X X |
Clear Cell Focus | X X X X |
Degeneration, Cystic | 2 1 |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 1 1 1 1 1 1|
Hepatodiaphragmatic Nodule | X X X X X X X X|
Hyperplasia | 3 |
Leukocytosis | 3 |
Mixed Cell Focus | X |
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 2 2 2 2 1 1 3 1 2 1 1 2 1 1 1 2 3 1 1|
__________________________________________________________________________|
Mesentery | + |
Fat, Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia | 3 |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
Necrosis | |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia | 1|
Inflammation, Chronic Active | 1 |
Mineralization | |
__________________________________________________________________________|
Tongue | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 6| 4| 4|
DAY ON TEST | 3| 1| 8| 7| 9| 3| 3| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 8| 7| 6| 6|
| 0| 6| 6| 3| 5| 0| 0| 2| 3| 2| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 0| 6| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 2 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 1 1 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 1 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Interstitial Cell, Hyperplasia | 1 2 2 2 2 2 2 2|
Seminiferous Tubule, Atrophy | 3 4 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Mediastinal, Angiectasis | |
Pancreatic, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 6| 4| 4|
DAY ON TEST | 3| 1| 8| 7| 9| 3| 3| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 8| 7| 6| 6|
| 0| 6| 6| 3| 5| 0| 0| 2| 3| 2| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 0| 6| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | |
Infarct | |
__________________________________________________________________________|
Thymus | + + + + + + + M M + + + + + + + + + + + + + + + +|
Cyst | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst Epithelial Inclusion | |
Hyperkeratosis | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Mineralization | |
Thrombosis | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
Degeneration | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia | 2 |
Bronchiole, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 2 |
Hyperkeratosis | |
Inflammation, Acute | 2 1 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 6| 4| 4|
DAY ON TEST | 3| 1| 8| 7| 9| 3| 3| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 8| 7| 6| 6|
| 0| 6| 6| 3| 5| 0| 0| 2| 3| 2| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 0| 6| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Developmental Malformation | |
Mineralization | |
Nephropathy | 3 2 2 3 1 3 3 2 2 1 3 3 3 3 3 3 2 3 1 2 2 3 3 1 2|
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
Pelvis, Transitional Epithelium, | |
Inflammation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 7| 7| 6| 6| 6| | |
DAY ON TEST | 9| 8| 1| 8| 6| 3| 3| 9| 6| 1| | |
| 1| 6| 2| 2| 1| 0| 0| 7| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 3 1 | 2 2.0|
Basophilic Focus | X 1 X | 20 1.0|
Clear Cell Focus | | 8 |
Degeneration, Cystic | | 5 1.6|
Eosinophilic Focus | X | 2 |
Fatty Change, Diffuse | 1 1 | 13 1.0|
Hepatodiaphragmatic Nodule | X | 11 |
Hyperplasia | | 1 3.0|
Leukocytosis | | 1 3.0|
Mixed Cell Focus | | 4 |
Necrosis, Focal | | 1 1.0|
Bile Duct, Hyperplasia | 2 2 3 2 2 1 2 1 2 | 46 1.6|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Acinus, Hyperplasia | | 2 3.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Hyperkeratosis | | 2 2.0|
Hyperplasia, Basal Cell | 1 2 1 | 5 1.4|
Necrosis | 3 3 | 3 3.0|
Ulcer | 2 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Hyperplasia | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 7| 7| 6| 6| 6| | |
DAY ON TEST | 9| 8| 1| 8| 6| 3| 3| 9| 6| 1| | |
| 1| 6| 2| 2| 1| 0| 0| 7| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 3 2 2 2 2 3 2 2 | 53 2.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hypertrophy | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 2 | 13 1.7|
Bilateral, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 56 |
Hyperplasia | | 1 3.0|
Bilateral, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | 2 2 | 12 2.1|
Pars Distalis, Cyst | | 4 |
Pars Distalis, Hyperplasia | 2 2 | 22 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | 2 | 9 1.3|
Follicular Cell, Hyperplasia | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + M | 58 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + M + + + + | 58 |
Inflammation, Chronic Active | 4 | 2 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
Interstitial Cell, Hyperplasia | | 14 1.9|
Seminiferous Tubule, Atrophy | 3 3 4 3 2 | 13 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 7| 7| 6| 6| 6| | |
DAY ON TEST | 9| 8| 1| 8| 6| 3| 3| 9| 6| 1| | |
| 1| 6| 2| 2| 1| 0| 0| 7| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood | + + + | 11 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 15 |
Mediastinal, Angiectasis | 3 | 1 3.0|
Pancreatic, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 2 | 3 2.3|
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + M + + + | 51 |
Cyst | | 1 |
Epithelial Cell, Hyperplasia | 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + | 58 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Abscess | | 1 4.0|
Cyst Epithelial Inclusion | | 1 |
Hyperkeratosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Hemorrhage | | 2 2.0|
Mineralization | | 1 1.0|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Degeneration | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 7| 7| 6| 6| 6| | |
DAY ON TEST | 9| 8| 1| 8| 6| 3| 3| 9| 6| 1| | |
| 1| 6| 2| 2| 1| 0| 0| 7| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | 1 | 3 1.3|
Infiltration Cellular, Histiocyte | | 2 2.0|
Inflammation, Acute | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 3 2.3|
Bronchiole, Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 2 2 1 | 7 1.9|
Hyperkeratosis | | 1 3.0|
Inflammation, Acute | 2 1 3 | 13 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 3 |
Developmental Malformation | X | 1 |
Mineralization | 1 | 2 1.0|
Nephropathy | 3 2 3 2 2 3 4 4 4 2 | 59 2.6|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 2.0|
Pelvis, Transitional Epithelium, | | |
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 1 |
Hemorrhage | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 5| 4| 4| 7| 6| 5| 5| 4| 7| 7| 7| 5| 5| 7| 6| 5| 4| 1|
DAY ON TEST | 3| 3| 5| 4| 6| 3| 3| 8| 6| 6| 3| 8| 5| 2| 6| 3| 3| 1| 7| 6| 3| 5| 2| 6| 9|
| 0| 0| 5| 7| 3| 0| 0| 9| 3| 2| 0| 1| 5| 5| 3| 0| 0| 6| 8| 8| 0| 8| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
8.3 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | 3|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 1 |
Basophilic Focus | X X 1 X X X 1 X 1 1 X 1 1 X X |
Clear Cell Focus | 1 X X 1 |
Degeneration, Cystic | 2 1 |
Eosinophilic Focus | 2 1 1 |
Fatty Change, Diffuse | 2 1 1 1 1 1 1 |
Fibrosis | |
Hepatodiaphragmatic Nodule | |
Infarct | 2 |
Mixed Cell Focus | |
Necrosis, Focal | 1 |
Thrombosis | 1 2 |
Artery, Necrosis | 2 |
Bile Duct, Hyperplasia | 1 3 3 3 1 2 3 1 2 3 3 2 1 2 3 2 |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Inflammation, Chronic Active | |
Fat, Hemorrhage | 4 |
Fat, Necrosis | |
Fat, Pigmentation | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia | 2 |
Artery, Fibrosis | 3 |
Artery, Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | 2 |
Hyperplasia, Squamous | |
Mineralization | 2 |
Necrosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 5| 4| 4| 7| 6| 5| 5| 4| 7| 7| 7| 5| 5| 7| 6| 5| 4| 1|
DAY ON TEST | 3| 3| 5| 4| 6| 3| 3| 8| 6| 6| 3| 8| 5| 2| 6| 3| 3| 1| 7| 6| 3| 5| 2| 6| 9|
| 0| 0| 5| 7| 3| 0| 0| 9| 3| 2| 0| 1| 5| 5| 3| 0| 0| 6| 8| 8| 0| 8| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
8.3 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 2 |
Mineralization | 2 2 1 2 2 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Acute | |
Mineralization | 3 1 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 2 3 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Necrosis | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 1 2 2 2 2 2 1 1 2 2 |
Seminiferous Tubule, Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 5| 4| 4| 7| 6| 5| 5| 4| 7| 7| 7| 5| 5| 7| 6| 5| 4| 1|
DAY ON TEST | 3| 3| 5| 4| 6| 3| 3| 8| 6| 6| 3| 8| 5| 2| 6| 3| 3| 1| 7| 6| 3| 5| 2| 6| 9|
| 0| 0| 5| 7| 3| 0| 0| 9| 3| 2| 0| 1| 5| 5| 3| 0| 0| 6| 8| 8| 0| 8| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
8.3 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood | + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Renal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 1 |
Hematopoietic Cell Proliferation | |
Infarct | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + M + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + |
Necrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Fibrosis | 1 |
Hemorrhage | 2 X 1 2 |
Infiltration Cellular, Histiocyte | 3 2 |
Inflammation, Acute | 1 |
Alveolar Epithelium, Hyperplasia | |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 3 |
Hyperkeratosis | |
Inflammation, Acute | 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 5| 4| 4| 7| 6| 5| 5| 4| 7| 7| 7| 5| 5| 7| 6| 5| 4| 1|
DAY ON TEST | 3| 3| 5| 4| 6| 3| 3| 8| 6| 6| 3| 8| 5| 2| 6| 3| 3| 1| 7| 6| 3| 5| 2| 6| 9|
| 0| 0| 5| 7| 3| 0| 0| 9| 3| 2| 0| 1| 5| 5| 3| 0| 0| 6| 8| 8| 0| 8| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
8.3 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Hemorrhage | 2 |
Mineralization | 1 |
Nephropathy | 3 2 2 4 2 3 4 2 3 2 4 3 1 1 1 3 3 3 4 1 4 3 1 1 |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 5| 5| 4| 7| 6| 4| 4| 4| 7| 6| 6| 5| 2| 7| 6| 6| 5| 5|
DAY ON TEST | 3| 3| 0| 9| 3| 2| 9| 8| 0| 6| 0| 4| 9| 6| 6| 2| 5| 2| 6| 5| 3| 5| 1| 6| 2|
| 0| 0| 4| 1| 0| 4| 6| 9| 1| 3| 0| 1| 7| 3| 3| 9| 4| 3| 8| 9| 0| 6| 2| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
8.3 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + A + + + + + + + + +|
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + A + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 |
Basophilic Focus | X X X X X X 1 X X 1 |
Clear Cell Focus | X X X |
Degeneration, Cystic | 1 1 |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 1 1 2 1 1 |
Fibrosis | 2 |
Hepatodiaphragmatic Nodule | X |
Infarct | 4 |
Mixed Cell Focus | X X |
Necrosis, Focal | |
Thrombosis | |
Artery, Necrosis | |
Bile Duct, Hyperplasia | 2 2 2 2 2 3 2 3 1 2 3 2 3 1 3 3 2|
__________________________________________________________________________|
Mesentery | + + + + |
Artery, Inflammation, Chronic Active | 2 |
Fat, Hemorrhage | 3 4 |
Fat, Necrosis | 2 2 |
Fat, Pigmentation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia | |
Artery, Fibrosis | |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 2 |
Hyperplasia, Basal Cell | 1 3 1 |
Hyperplasia, Squamous | 3 |
Mineralization | |
Necrosis | 2 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 5| 5| 4| 7| 6| 4| 4| 4| 7| 6| 6| 5| 2| 7| 6| 6| 5| 5|
DAY ON TEST | 3| 3| 0| 9| 3| 2| 9| 8| 0| 6| 0| 4| 9| 6| 6| 2| 5| 2| 6| 5| 3| 5| 1| 6| 2|
| 0| 0| 4| 1| 0| 4| 6| 9| 1| 3| 0| 1| 7| 3| 3| 9| 4| 3| 8| 9| 0| 6| 2| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
8.3 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | |
Mineralization | 2 2 2 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 3 2 2 2 2 2 2 1 2 2 2 3 2 2 2 2|
Inflammation, Acute | |
Mineralization | 2 1 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + M + + + + + +|
Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 3 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Necrosis | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2|
Seminiferous Tubule, Atrophy | 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 5| 5| 4| 7| 6| 4| 4| 4| 7| 6| 6| 5| 2| 7| 6| 6| 5| 5|
DAY ON TEST | 3| 3| 0| 9| 3| 2| 9| 8| 0| 6| 0| 4| 9| 6| 6| 2| 5| 2| 6| 5| 3| 5| 1| 6| 2|
| 0| 0| 4| 1| 0| 4| 6| 9| 1| 3| 0| 1| 7| 3| 3| 9| 4| 3| 8| 9| 0| 6| 2| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
8.3 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood | + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Renal, Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 |
Infarct | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + M M M + + + + + + M + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 1 |
Fibrosis | |
Hemorrhage | 2 1 2 1 1 2 1|
Infiltration Cellular, Histiocyte | 2 1 |
Inflammation, Acute | 3 |
Alveolar Epithelium, Hyperplasia | |
Artery, Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 2 |
Hyperkeratosis | 2 |
Inflammation, Acute | 2 1 1 2 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 5| 5| 4| 7| 6| 4| 4| 4| 7| 6| 6| 5| 2| 7| 6| 6| 5| 5|
DAY ON TEST | 3| 3| 0| 9| 3| 2| 9| 8| 0| 6| 0| 4| 9| 6| 6| 2| 5| 2| 6| 5| 3| 5| 1| 6| 2|
| 0| 0| 4| 1| 0| 4| 6| 9| 1| 3| 0| 1| 7| 3| 3| 9| 4| 3| 8| 9| 0| 6| 2| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
8.3 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | |
Mineralization | 2 2 1 |
Nephropathy | 3 4 3 1 3 2 4 2 1 2 4 3 2 1 2 3 2 2 2 4 2 1 1|
Renal Tubule, Hyperplasia | 4 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 5| 4| 4| 1| | |
DAY ON TEST | 3| 3| 2| 7| 7| 3| 7| 6| 6| 8| | |
| 0| 0| 5| 5| 5| 0| 0| 2| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
8.3 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 57 |
Artery, Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 7 1.7|
Basophilic Focus | X 1 1 1 1 X X | 32 1.0|
Clear Cell Focus | | 7 1.0|
Degeneration, Cystic | | 4 1.3|
Eosinophilic Focus | 4 | 5 2.0|
Fatty Change, Diffuse | 1 1 1 | 15 1.1|
Fibrosis | | 1 2.0|
Hepatodiaphragmatic Nodule | | 1 |
Infarct | | 2 3.0|
Mixed Cell Focus | X | 3 |
Necrosis, Focal | | 1 1.0|
Thrombosis | | 2 1.5|
Artery, Necrosis | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 2 3 2 2 | 39 2.2|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Artery, Inflammation, Chronic Active | | 1 2.0|
Fat, Hemorrhage | | 3 3.7|
Fat, Necrosis | | 2 2.0|
Fat, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Hyperplasia | | 1 2.0|
Artery, Fibrosis | | 1 3.0|
Artery, Inflammation, Chronic Active | 1 | 3 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Duct, Metaplasia, Squamous | | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | 2 2 | 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 5| 4| 4| 1| | |
DAY ON TEST | 3| 3| 2| 7| 7| 3| 7| 6| 6| 8| | |
| 0| 0| 5| 5| 5| 0| 0| 2| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
8.3 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Basal Cell | 2 1 2 | 7 1.7|
Hyperplasia, Squamous | | 1 3.0|
Mineralization | | 1 2.0|
Necrosis | 1 3 | 6 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
Mineralization | 1 1 | 10 1.7|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | X 2 2 2 2 2 2 | 39 2.0|
Inflammation, Acute | 1 | 1 1.0|
Mineralization | X 2 | 6 1.8|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 2 1 | 15 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
Hyperplasia | 2 2 | 8 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | | 7 2.3|
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia | 2 2 2 | 14 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | | 2 1.0|
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 5| 4| 4| 1| | |
DAY ON TEST | 3| 3| 2| 7| 7| 3| 7| 6| 6| 8| | |
| 0| 0| 5| 5| 5| 0| 0| 2| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
8.3 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | 2 2 1 | 20 1.8|
Seminiferous Tubule, Atrophy | | 5 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 12 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | | 16 |
Renal, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 3 | 6 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Infarct | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M M + + + M + + + + | 53 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + M + + + | 52 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 6 |
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 5| 4| 4| 1| | |
DAY ON TEST | 3| 3| 2| 7| 7| 3| 7| 6| 6| 8| | |
| 0| 0| 5| 5| 5| 0| 0| 2| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
8.3 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Edema | 2 | 4 1.8|
Fibrosis | | 1 1.0|
Hemorrhage | | 11 1.5|
Infiltration Cellular, Histiocyte | | 4 2.0|
Inflammation, Acute | | 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Artery, Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 5 2.2|
Hyperkeratosis | | 1 2.0|
Inflammation, Acute | 2 | 11 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 3 |
Hemorrhage | | 1 2.0|
Mineralization | 2 3 | 6 1.8|
Nephropathy | 2 3 4 4 3 4 2 2 2 | 56 2.5|
Renal Tubule, Hyperplasia | 4 2 | 5 3.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 7| 6| 5| 5| 4| 7| 7| 6| 5| 4| 7| 7| 6| 4| 4| 7| 7| 6| 6| 5|
DAY ON TEST | 2| 1| 9| 8| 6| 2| 6| 7| 2| 6| 2| 0| 6| 9| 7| 2| 0| 6| 6| 0| 2| 2| 7| 2| 5|
| 5| 6| 7| 2| 3| 2| 5| 5| 0| 3| 5| 1| 6| 8| 9| 5| 0| 6| 2| 1| 5| 5| 3| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
16.6 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperkeratosis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + A + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + A + A + + + + A + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + A + A + + + + A + + A + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + A + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A A + A + + + + A + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + A + A + + + + A + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 1 X X X 1 2 |
Clear Cell Focus | X X 1 2 1 |
Degeneration, Cystic | 2 2 2 |
Eosinophilic Focus | 4 3 X 1 |
Fatty Change, Diffuse | 1 2 1 2 2 1 2 1 1 1 1|
Hematopoietic Cell Proliferation | 2|
Hepatodiaphragmatic Nodule | |
Mixed Cell Focus | X X X |
Necrosis | 1 3 2 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 1 1 3 2 2 1 1|
Centrilobular, Hypertrophy | |
__________________________________________________________________________|
Mesentery | |
Fat, Hemorrhage | |
Fat, Mineralization | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | 2 1 |
Inflammation, Acute | |
Necrosis | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + A + + + + A + + + + + + + + + + +|
Mineralization | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 7| 6| 5| 5| 4| 7| 7| 6| 5| 4| 7| 7| 6| 4| 4| 7| 7| 6| 6| 5|
DAY ON TEST | 2| 1| 9| 8| 6| 2| 6| 7| 2| 6| 2| 0| 6| 9| 7| 2| 0| 6| 6| 0| 2| 2| 7| 2| 5|
| 5| 6| 7| 2| 3| 2| 5| 5| 0| 3| 5| 1| 6| 8| 9| 5| 0| 6| 2| 1| 5| 5| 3| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
16.6 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + + + + + + + + + + M + + + + + +|
Hyperplasia | 2 2 3 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + M + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Fibrosis | |
Pars Distalis, Hyperplasia | 2 2 3 3 1 3 2 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + M + A + + + + A + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + M + + + + + + + + + + M|
Hyperplasia | 2 |
Necrosis | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | |
Mineralization | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 3 2 1 |
Seminiferous Tubule, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Mediastinal, Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 7| 6| 5| 5| 4| 7| 7| 6| 5| 4| 7| 7| 6| 4| 4| 7| 7| 6| 6| 5|
DAY ON TEST | 2| 1| 9| 8| 6| 2| 6| 7| 2| 6| 2| 0| 6| 9| 7| 2| 0| 6| 6| 0| 2| 2| 7| 2| 5|
| 5| 6| 7| 2| 3| 2| 5| 5| 0| 3| 5| 1| 6| 8| 9| 5| 0| 6| 2| 1| 5| 5| 3| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
16.6 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +|
Fibrosis | 3 1 |
Hematopoietic Cell Proliferation | 3 3|
Infarct | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + M M + + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Fibrosis | 1 |
Hemorrhage | 3 |
Inflammation, Acute | |
Mediastinum, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | 2 |
Mineralization | 2 2 |
Nephropathy | 4 2 1 2 2 4 4 2 2 3 3 4 2 2 4 4 2 2 1 3 3 2 3 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 6| 6| 4| 1| 7| 6| 6| 6| 5| 7| 7| 6| 5| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 2| 2| 4| 2| 1| 0| 9| 7| 6| 8| 2| 9| 9| 5| 9| 2| 1| 6| 3| 6| 0| 0| 4| 3| 6|
| 5| 5| 2| 6| 6| 4| 7| 3| 3| 4| 5| 4| 1| 6| 9| 5| 5| 5| 6| 2| 2| 0| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
16.6 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperkeratosis | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A A + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 1 X X X X 1 1 X X 1 1 X X X X |
Clear Cell Focus | 1 X X |
Degeneration, Cystic | 1 2 1 |
Eosinophilic Focus | 3 |
Fatty Change, Diffuse | 1 1 1 1 1 2 1 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X X X X X |
Necrosis | 2 1 |
Bile Duct, Cyst | 1 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 3 2 3 2 |
Centrilobular, Hypertrophy | 1|
__________________________________________________________________________|
Mesentery | + + |
Fat, Hemorrhage | |
Fat, Mineralization | 2 |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
Inflammation, Acute | |
Necrosis | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 3 2 3 2 2 2 2 2 2 2 2 3 2 2 2 2|
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 6| 6| 4| 1| 7| 6| 6| 6| 5| 7| 7| 6| 5| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 2| 2| 4| 2| 1| 0| 9| 7| 6| 8| 2| 9| 9| 5| 9| 2| 1| 6| 3| 6| 0| 0| 4| 3| 6|
| 5| 5| 2| 6| 6| 4| 7| 3| 3| 4| 5| 4| 1| 6| 9| 5| 5| 5| 6| 2| 2| 0| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
16.6 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | 1 3 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Fibrosis | |
Pars Distalis, Hyperplasia | 2 3 3 3 2 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + A A + + + + + + +|
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Necrosis | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
Inflammation, Chronic Active | 3 |
Mineralization | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 2 2|
Seminiferous Tubule, Atrophy | 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 6| 6| 4| 1| 7| 6| 6| 6| 5| 7| 7| 6| 5| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 2| 2| 4| 2| 1| 0| 9| 7| 6| 8| 2| 9| 9| 5| 9| 2| 1| 6| 3| 6| 0| 0| 4| 3| 6|
| 5| 5| 2| 6| 6| 4| 7| 3| 3| 4| 5| 4| 1| 6| 9| 5| 5| 5| 6| 2| 2| 0| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
16.6 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | |
Infarct | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + M + + + + + + + + + + + +|
Ectopic Parathyroid Gland | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + M + + + + + M + + + + + + M + M + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Fibrosis | |
Hemorrhage | 2 2 |
Inflammation, Acute | 1 |
Mediastinum, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2|
Inflammation, Acute | 1 1 3 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hydronephrosis | 2 |
Mineralization | 2 3 2 |
Nephropathy | 2 4 4 3 3 4 3 3 3 3 3 3 3 3 3 3 4 2 2 4 4 3 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 4| 4| 6| 5| 5| 4| 4| | |
DAY ON TEST | 1| 7| 5| 6| 6| 3| 7| 2| 6| 6| | |
| 8| 1| 5| 3| 3| 9| 0| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
16.6 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Hemorrhage | | 1 3.0|
Hyperkeratosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + A + + + + + M + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + | 52 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + A + + A + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.0|
Basophilic Focus | X X 1 | 25 1.2|
Clear Cell Focus | | 8 1.3|
Degeneration, Cystic | 1 | 7 1.6|
Eosinophilic Focus | | 5 2.8|
Fatty Change, Diffuse | 1 2 2 1 2 2 | 25 1.4|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | | 1 |
Mixed Cell Focus | | 8 |
Necrosis | | 5 1.8|
Bile Duct, Cyst | | 1 1.0|
Bile Duct, Hyperplasia | 2 2 1 2 | 22 1.9|
Centrilobular, Hypertrophy | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Hemorrhage | 4 | 1 4.0|
Fat, Mineralization | | 1 2.0|
Fat, Necrosis | | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Duct, Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | | 1 2.0|
Hyperplasia, Basal Cell | | 2 1.5|
Inflammation, Acute | 2 | 1 2.0|
Necrosis | | 2 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 57 |
Mineralization | 1 | 8 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 4| 4| 6| 5| 5| 4| 4| | |
DAY ON TEST | 1| 7| 5| 6| 6| 3| 7| 2| 6| 6| | |
| 8| 1| 5| 3| 3| 9| 0| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
16.6 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 2 2 2 | 46 2.1|
Inflammation, Acute | | 1 2.0|
Mineralization | | 5 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Accessory Adrenal Cortical Nodule | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + M + + + + + + + | 59 |
Hyperplasia | 2 2 | 14 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
Hyperplasia | 2 | 8 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | 3 2 | 6 2.2|
Pars Distalis, Cyst | | 4 |
Pars Distalis, Fibrosis | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 1 3 2 | 16 2.3|
Pars Nervosa, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + A + + + + + + + | 54 |
C-Cell, Hyperplasia | | 1 1.0|
Follicle, Cyst | X | 1 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
Hyperplasia | | 1 2.0|
Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Hyperplasia | | 3 2.0|
Inflammation, Chronic Active | | 1 3.0|
Mineralization | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 4| 4| 6| 5| 5| 4| 4| | |
DAY ON TEST | 1| 7| 5| 6| 6| 3| 7| 2| 6| 6| | |
| 8| 1| 5| 3| 3| 9| 0| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
16.6 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | 2 2 2 2 1 2 2 2 | 19 1.9|
Seminiferous Tubule, Atrophy | | 3 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + | 13 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 15 |
Mediastinal, Angiectasis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Fibrosis | 2 | 4 1.8|
Hematopoietic Cell Proliferation | | 2 3.0|
Infarct | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + | 56 |
Ectopic Parathyroid Gland | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + M + + + M | 47 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Edema | 2 | 3 2.0|
Fibrosis | | 1 1.0|
Hemorrhage | | 3 2.3|
Inflammation, Acute | 3 | 2 2.0|
Mediastinum, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 4| 4| 6| 5| 5| 4| 4| | |
DAY ON TEST | 1| 7| 5| 6| 6| 3| 7| 2| 6| 6| | |
| 8| 1| 5| 3| 3| 9| 0| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
16.6 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Fungus | | 1 2.0|
Inflammation, Acute | 1 3 | 8 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 2 2.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 2 |
Hydronephrosis | | 2 2.0|
Mineralization | | 5 2.2|
Nephropathy | 4 2 2 2 1 4 2 2 2 2 | 58 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 5| 5| 4| 1| 6| 6| 4| 4| 0| 6| 5| 5| 4| 3| 2| 7| 7| 6| 4|
DAY ON TEST | 1| 5| 5| 0| 6| 2| 9| 6| 6| 3| 7| 2| 6| 6| 4| 6| 8| 6| 6| 6| 8| 1| 1| 1| 6|
| 7| 8| 6| 4| 8| 5| 2| 2| 3| 8| 5| 4| 3| 2| 9| 7| 4| 5| 2| 5| 8| 7| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
33.3 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Acute | |
Necrosis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + A A + + + + A + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + A + + A + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A A + A + + A M + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A A + A + + A + + + + + A + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + A + + A + + + + + A + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X 1 X X X X 2 |
Clear Cell Focus | X X X 1 X X |
Degeneration, Cystic | 2 2 2 |
Eosinophilic Focus | 3 2 |
Fatty Change, Diffuse | 1 2 1 1 1 1 2 2 2 2 2 1 2 2 1 1 3 2|
Fatty Change, Focal | |
Hepatodiaphragmatic Nodule | |
Hyperplasia | 2 |
Mixed Cell Focus | X X X X X |
Necrosis, Focal | 2 |
Necrosis | 2 |
Thrombosis | |
Bile Duct, Hyperplasia | 3 2 2 2 |
Centrilobular, Hypertrophy | 1 1 1 1|
__________________________________________________________________________|
Mesentery | + + + |
Fat, Fibrosis | 2 |
Fat, Inflammation, Chronic Active | 2 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pharynx | + |
Inflammation, Acute | 3 |
Palate, Inflammation, Acute | |
__________________________________________________________________________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | 2 |
Hyperplasia, Squamous | |
Necrosis | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + A A + + + + A + + + + + + + A + + + + + + +|
Necrosis | 2 2 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 5| 5| 4| 1| 6| 6| 4| 4| 0| 6| 5| 5| 4| 3| 2| 7| 7| 6| 4|
DAY ON TEST | 1| 5| 5| 0| 6| 2| 9| 6| 6| 3| 7| 2| 6| 6| 4| 6| 8| 6| 6| 6| 8| 1| 1| 1| 6|
| 7| 8| 6| 4| 8| 5| 2| 2| 3| 8| 5| 4| 3| 2| 9| 7| 4| 5| 2| 5| 8| 7| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
33.3 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | + |
Hyperkeratosis | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 2 3 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 |
Congestion | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | 1 1 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 2 3 1 3 |
Pars Distalis, Infarct | |
__________________________________________________________________________|
Thyroid Gland | + + + M A + A + + A + + + + + + + A + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 1 1 2|
Seminiferous Tubule, Atrophy | 3 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 5| 5| 4| 1| 6| 6| 4| 4| 0| 6| 5| 5| 4| 3| 2| 7| 7| 6| 4|
DAY ON TEST | 1| 5| 5| 0| 6| 2| 9| 6| 6| 3| 7| 2| 6| 6| 4| 6| 8| 6| 6| 6| 8| 1| 1| 1| 6|
| 7| 8| 6| 4| 8| 5| 2| 2| 3| 8| 5| 4| 3| 2| 9| 7| 4| 5| 2| 5| 8| 7| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
33.3 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | 2 1 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M M + + + + M M + + + M + + + + +|
Galactocele | X X |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Edema | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | 3 3 |
Mediastinum, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 2 2 |
Inflammation, Acute | 3 3 3 1 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 5| 5| 4| 1| 6| 6| 4| 4| 0| 6| 5| 5| 4| 3| 2| 7| 7| 6| 4|
DAY ON TEST | 1| 5| 5| 0| 6| 2| 9| 6| 6| 3| 7| 2| 6| 6| 4| 6| 8| 6| 6| 6| 8| 1| 1| 1| 6|
| 7| 8| 6| 4| 8| 5| 2| 2| 3| 8| 5| 4| 3| 2| 9| 7| 4| 5| 2| 5| 8| 7| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
33.3 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hemorrhage | |
Mineralization | |
Nephropathy | 3 2 4 3 2 2 2 4 2 3 4 3 3 4 4 2 2 2 3 3 3 2|
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + A + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 6| 6| 6| 5| 4| 7| 6| 6| 6| 5| 7| 6| 6| 5| 4| 7| 7| 6| 6| 4|
DAY ON TEST | 1| 1| 1| 7| 6| 5| 2| 0| 9| 6| 1| 8| 6| 3| 5| 1| 9| 5| 4| 5| 1| 1| 6| 0| 6|
| 7| 5| 2| 6| 2| 8| 4| 2| 2| 2| 7| 0| 6| 2| 5| 7| 3| 7| 1| 8| 7| 7| 7| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
33.3 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 1 2 |
Inflammation, Acute | 3 |
Necrosis | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + A + + + A A + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + A + + + + + A + + + A A + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + A + + + + + A + + + A A + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + A + + + + + A + + + A A + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + A + + + + + A + + + A A + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 X X X X 1 1 |
Clear Cell Focus | X 1 X |
Degeneration, Cystic | 2 |
Eosinophilic Focus | 4 1 |
Fatty Change, Diffuse | 2 1 3 1 3 1 2 1 1 2 2 2 1 3|
Fatty Change, Focal | 1 |
Hepatodiaphragmatic Nodule | |
Hyperplasia | |
Mixed Cell Focus | X 1 X X X X |
Necrosis, Focal | |
Necrosis | |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 3 1 3 2 2 2 1 3 |
Centrilobular, Hypertrophy | 1 1 1|
__________________________________________________________________________|
Mesentery | |
Fat, Fibrosis | |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pharynx | + |
Inflammation, Acute | |
Palate, Inflammation, Acute | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 2 3 3 |
Hyperplasia, Basal Cell | 2 2 2 2 |
Hyperplasia, Squamous | 4 |
Necrosis | |
Ulcer | 2 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 6| 6| 6| 5| 4| 7| 6| 6| 6| 5| 7| 6| 6| 5| 4| 7| 7| 6| 6| 4|
DAY ON TEST | 1| 1| 1| 7| 6| 5| 2| 0| 9| 6| 1| 8| 6| 3| 5| 1| 9| 5| 4| 5| 1| 1| 6| 0| 6|
| 7| 5| 2| 6| 2| 8| 4| 2| 2| 2| 7| 0| 6| 2| 5| 7| 3| 7| 1| 8| 7| 7| 7| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
33.3 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2|
Congestion | 3 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + + + + + M + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Hyperplasia | 2 2 2 |
Pars Distalis, Infarct | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + + + A + + A A A + + + + +|
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + M +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 1 2|
Seminiferous Tubule, Atrophy | 3 3 3 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 6| 6| 6| 5| 4| 7| 6| 6| 6| 5| 7| 6| 6| 5| 4| 7| 7| 6| 6| 4|
DAY ON TEST | 1| 1| 1| 7| 6| 5| 2| 0| 9| 6| 1| 8| 6| 3| 5| 1| 9| 5| 4| 5| 1| 1| 6| 0| 6|
| 7| 5| 2| 6| 2| 8| 4| 2| 2| 2| 7| 0| 6| 2| 5| 7| 3| 7| 1| 8| 7| 7| 7| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
33.3 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Fibrosis | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M M + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + M + + + + + M + M + + + + M + M|
Galactocele | |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Edema | 2 |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Acute | 2 3 |
Mediastinum, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Acute | 3 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4 |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | I |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 6| 6| 6| 5| 4| 7| 6| 6| 6| 5| 7| 6| 6| 5| 4| 7| 7| 6| 6| 4|
DAY ON TEST | 1| 1| 1| 7| 6| 5| 2| 0| 9| 6| 1| 8| 6| 3| 5| 1| 9| 5| 4| 5| 1| 1| 6| 0| 6|
| 7| 5| 2| 6| 2| 8| 4| 2| 2| 2| 7| 0| 6| 2| 5| 7| 3| 7| 1| 8| 7| 7| 7| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
33.3 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage | 4 |
Mineralization | |
Nephropathy | 3 4 2 2 1 3 3 2 3 2 3 3 3 4 2 2 3 3 1 1 3 4 4 2 1|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | |
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 2| 6| 7| 6| 5| 0| | |
DAY ON TEST | 1| 0| 3| 6| 8| 2| 1| 2| 8| 5| | |
| 7| 8| 9| 3| 9| 0| 7| 4| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
33.3 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Hyperkeratosis | | 3 1.7|
Inflammation, Acute | | 1 3.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A A + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A A + + A + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A A + + A + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A A + + A + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A A + + A + | 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X 1 X 1 | 23 1.1|
Clear Cell Focus | X X X X | 13 1.0|
Degeneration, Cystic | | 4 2.0|
Eosinophilic Focus | | 4 2.5|
Fatty Change, Diffuse | 2 2 2 3 2 | 37 1.8|
Fatty Change, Focal | | 1 1.0|
Hepatodiaphragmatic Nodule | X | 1 |
Hyperplasia | | 1 2.0|
Mixed Cell Focus | | 11 1.0|
Necrosis, Focal | | 1 2.0|
Necrosis | | 1 2.0|
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | | 12 2.2|
Centrilobular, Hypertrophy | 1 | 8 1.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Fibrosis | | 1 2.0|
Fat, Inflammation, Chronic Active | | 1 2.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Pharynx | | 2 |
Inflammation, Acute | | 1 3.0|
Palate, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Duct, Metaplasia, Squamous | | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 |
Hyperkeratosis | | 4 2.5|
Hyperplasia, Basal Cell | 2 | 6 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 2| 6| 7| 6| 5| 0| | |
DAY ON TEST | 1| 0| 3| 6| 8| 2| 1| 2| 8| 5| | |
| 7| 8| 9| 3| 9| 0| 7| 4| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
33.3 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Squamous | | 1 4.0|
Necrosis | | 1 2.0|
Ulcer | | 4 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + | 54 |
Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Hyperkeratosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 1 2 2 2 2 2 1 | 52 2.0|
Congestion | | 1 3.0|
Mineralization | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | 2 | 9 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 56 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + I | 59 |
Pars Distalis, Angiectasis | | 3 2.0|
Pars Distalis, Hyperplasia | 2 1 | 9 2.0|
Pars Distalis, Infarct | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
C-Cell, Hyperplasia | | 1 1.0|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + M + + + + + + | 58 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Prostate | M + M + + + + + + + | 57 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 2| 6| 7| 6| 5| 0| | |
DAY ON TEST | 1| 0| 3| 6| 8| 2| 1| 2| 8| 5| | |
| 7| 8| 9| 3| 9| 0| 7| 4| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
33.3 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | 2 | 14 1.8|
Seminiferous Tubule, Atrophy | | 8 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 7 |
__________________________________________________________________________|____________|
Bone Marrow | + + M + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Cyst | | 1 |
Fibrosis | | 4 1.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + | 55 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M M + + + + M | 46 |
Galactocele | | 2 |
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + M + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Edema | | 1 2.0|
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Edema | 1 | 5 2.2|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05108-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROMETHAZINE HYDROCHLORIDE Date: 04/25/97
Route: GAVAGE Time: 08:43:56
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 2| 6| 7| 6| 5| 0| | |
DAY ON TEST | 1| 0| 3| 6| 8| 2| 1| 2| 8| 5| | |
| 7| 8| 9| 3| 9| 0| 7| 4| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
33.3 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Acute | | 4 2.8|
Mediastinum, Inflammation, Chronic | | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 5 2.0|
Inflammation, Acute | 1 | 9 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Erosion | | 1 4.0|
Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | X | 4 |
Hemorrhage | | 1 4.0|
Mineralization | 2 | 1 2.0|
Nephropathy | 3 4 3 2 1 3 3 3 2 | 56 2.7|
Renal Tubule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 1 |
Dilatation | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
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---------- END OF REPORT ----------
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