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TDMS Study 05109-12 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          TRIETHANOLAMINE


NTP Experiment-Test: 05109-12                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  102-71-6

       Lock Date:  08/21/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05109-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            4            5           11                                     
    Natural Death                                      4            6            7            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           40           38           37                                     
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Intestine Small, Jejunum                           (60)         (60)         (60)         (60)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                          2 (3%)                                                          
   Liver                                              (60)         (60)         (60)         (60)                                   
      Basophilic Focus                                              2 (3%)       2 (3%)       1 (2%)                                
      Clear Cell Focus                                 1 (2%)       1 (2%)                    1 (2%)                                
      Congestion                                                                 1 (2%)                                             
      Cytoplasmic Alteration                                        1 (2%)                                                          
      Eosinophilic Focus                              11 (18%)     10 (17%)     18 (30%)     17 (28%)                               
      Fatty Change                                                                            1 (2%)                                
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hepatodiaphragmatic Nodule                                    1 (2%)                                                          
      Hypertrophy                                      1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                                          2 (3%)                                             
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
      Karyomegaly                                                   1 (2%)                                                          
      Leukocytosis                                     1 (2%)                                                                       
      Necrosis                                         2 (3%)       3 (5%)       2 (3%)       1 (2%)                                
      Kupffer Cell, Hyperplasia                                                               1 (2%)                                
   Mesentery                                          (2)          (5)          (5)          (5)                                    
      Fat, Infiltration Cellular, Lymphocyte                                     1 (20%)                                            
      Fat, Inflammation, Chronic                       2 (100%)     4 (80%)      3 (60%)      3 (60%)                               
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Cyst                                                          1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Acinus, Atrophy                                  4 (7%)       2 (3%)       1 (2%)                                             
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
      Duct, Cyst                                                                 1 (2%)                                             
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Acanthosis                                       1 (2%)                    1 (2%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05109-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Hyperplasia                                      1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Pigmentation                                                  1 (2%)                    1 (2%)                                
      Ulcer                                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Artery, Thrombosis                               1 (2%)                                                                       
      Coronary Artery, Inflammation, Chronic           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (60)         (60)                                   
      Hyperplasia                                                                             1 (2%)                                
      Hypertrophy                                      3 (5%)       2 (3%)       3 (5%)       1 (2%)                                
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
      Capsule, Accessory Adrenal Cortical Nodule       2 (3%)                                 2 (3%)                                
      Capsule, Cyst                                                 1 (2%)       1 (2%)                                             
      Capsule, Spindle Cell, Hyperplasia                            1 (2%)       1 (2%)                                             
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Cyst                                                                       1 (2%)                                             
      Hyperplasia                                      1 (2%)       3 (5%)                    3 (5%)                                
   Pituitary Gland                                    (54)         (59)         (59)         (59)                                   
      Pars Distalis, Angiectasis                                                              1 (2%)                                
      Pars Distalis, Cyst                              1 (2%)       2 (3%)                    1 (2%)                                
      Pars Distalis, Hyperplasia                       3 (6%)       7 (12%)      8 (14%)      5 (8%)                                
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
      Rathke's Cleft, Cyst                             1 (2%)                                                                       
      Rathke's Cleft, Hemorrhage                                                              1 (2%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Follicle, Cyst                                                1 (2%)                    2 (3%)                                
      Follicular Cell, Hyperplasia                    23 (38%)     20 (33%)     18 (30%)     27 (45%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05109-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (58)         (58)         (56)         (58)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Duct, Ectasia                                    3 (5%)       1 (2%)       2 (4%)       3 (5%)                                
   Ovary                                              (59)         (60)         (59)         (60)                                   
      Atrophy                                         34 (58%)     37 (62%)     34 (58%)     29 (48%)                               
      Cyst                                                          1 (2%)                                                          
      Thrombosis                                                    2 (3%)       2 (3%)       1 (2%)                                
      Follicle, Cyst                                  15 (25%)     19 (32%)     18 (31%)     14 (23%)                               
      Follicle, Cyst, Multiple                                                   1 (2%)                                             
      Periovarian Tissue, Cyst                                      1 (2%)       1 (2%)                                             
      Periovarian Tissue, Infiltration Cellular,                                                                                    
           Lymphocyte                                                            1 (2%)                                             
      Periovarian Tissue, Inflammation, Chronic                                                                                     
          Active                                                    1 (2%)                                                          
   Uterus                                             (60)         (60)         (59)         (60)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic, Glandular     57 (95%)     58 (97%)     56 (95%)     53 (88%)                               
      Lymphatic, Ectasia                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Myelofibrosis                                    7 (12%)     16 (27%)      4 (7%)       7 (12%)                               
      Myeloid Cell, Atrophy                                                                   1 (2%)                                
   Lymph Node                                         (4)          (8)          (6)          (9)                                    
      Mediastinal, Hyperplasia, Lymphoid               1 (25%)                   1 (17%)                                            
   Lymph Node, Mandibular                             (57)         (59)         (59)         (59)                                   
      Hyperplasia, Lymphoid                                         1 (2%)       2 (3%)       1 (2%)                                
   Lymph Node, Mesenteric                             (54)         (59)         (56)         (59)                                   
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Hematopoietic Cell Proliferation                 3 (5%)       9 (15%)      3 (5%)       6 (10%)                               
      Hyperplasia, Lymphoid                                         5 (8%)       5 (8%)                                             
      Necrosis                                                                   1 (2%)                                             
   Thymus                                             (55)         (57)         (58)         (58)                                   
      Atrophy                                         19 (35%)     28 (49%)     28 (48%)     22 (38%)                               
      Cyst                                                                                    1 (2%)                                
      Hyperplasia, Lymphoid                                         1 (2%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05109-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (57)         (60)         (57)                                   
      Hyperplasia, Glandular                                                                  1 (2%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Acanthosis                                                                 1 (2%)                                             
      Inguinal, Inflammation, Chronic                                                         1 (2%)                                
      Site of Application-No Mass, Acanthosis                       3 (5%)       1 (2%)       5 (8%)                                
      Site of Application-No Mass, Inflammation,                                                                                    
           Chronic                                                  2 (3%)       2 (3%)       8 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Vertebra, Coccygeal, Fracture                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                      3 (5%)       3 (5%)       1 (2%)       1 (2%)                                
      Hemorrhage                                                                              2 (3%)                                
      Medulla, Hemorrhage                                                        1 (2%)                                             
   Peripheral Nerve                                   (2)          (1)                       (1)                                    
      Sciatic, Degeneration                                                                   1 (100%)                              
   Spinal Cord                                        (2)          (1)                       (1)                                    
      Nerve, Degeneration                              1 (50%)      1 (100%)                  1 (100%)                              
      White Matter, Degeneration                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (59)                                   
      Hemorrhage, Focal                                                          1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)                    1 (2%)                                
      Mineralization, Focal                                                                   1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)                                 1 (2%)                                
      Alveolar Epithelium, Hyperplasia, Macrophage                  1 (2%)                                                          
      Pleura, Hyperplasia                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                       (1)          (1)                                    
      Internal Ear, Hyperplasia, Glandular                                       1 (100%)                                           
   Harderian Gland                                    (1)          (2)          (1)                                                 
      Acinus, Hyperplasia                                           1 (50%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05109-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Nephropathy, Chronic                            22 (37%)     30 (50%)     30 (50%)     25 (42%)                               
      Cortex, Cyst                                     1 (2%)                                                                       
      Cortex, Infarct                                               3 (5%)       2 (3%)                                             
      Pelvis, Inflammation, Acute                      1 (2%)                                                                       
      Renal Tubule, Hyperplasia, Cystic                                                       1 (2%)                                
      Renal Tubule, Necrosis                                        1 (2%)                                                          
   Urinary Bladder                                    (60)         (60)         (59)         (60)                                   
      Inflammation, Chronic Active                                  1 (2%)                    1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05109-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            5            3            6                                     
    Natural Death                                      2            5            8            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                46           39           39           41                                     
    Natural Death                                                   1                                                               
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (59)         (58)         (58)         (59)                                   
      Cyst                                             1 (2%)                                                                       
   Intestine Small, Jejunum                           (60)         (60)         (60)         (60)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                                                    1 (2%)                                
   Liver                                              (60)         (60)         (60)         (60)                                   
      Basophilic Focus                                 7 (12%)      3 (5%)       4 (7%)       3 (5%)                                
      Clear Cell Focus                                13 (22%)     11 (18%)      7 (12%)      5 (8%)                                
      Congestion                                                    1 (2%)                                                          
      Cyst                                                                       1 (2%)                                             
      Cytoplasmic Alteration                          10 (17%)     17 (28%)     10 (17%)     16 (27%)                               
      Eosinophilic Focus                              10 (17%)     17 (28%)     11 (18%)     24 (40%)                               
      Fatty Change                                                               1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Karyomegaly                                     13 (22%)     18 (30%)     10 (17%)     18 (30%)                               
      Mixed Cell Focus                                 2 (3%)                                 3 (5%)                                
      Necrosis                                         1 (2%)                                 2 (3%)                                
      Thrombosis                                       1 (2%)                                                                       
      Bile Duct, Hyperplasia                           2 (3%)       2 (3%)                    1 (2%)                                
      Hepatocyte, Cytoplasmic Alteration               3 (5%)       1 (2%)       1 (2%)       2 (3%)                                
      Hepatocyte, Cytoplasmic Alteration, Focal                                  1 (2%)                                             
      Hepatocyte, Necrosis                                          1 (2%)                                                          
      Hepatocyte, Vacuolization Cytoplasmic,                                                                                        
          Multifocal                                   4 (7%)       6 (10%)      3 (5%)       6 (10%)                               
      Kupffer Cell, Hyperplasia                                     1 (2%)                                                          
      Oval Cell, Hyperplasia                          12 (20%)     15 (25%)     10 (17%)     19 (32%)                               
   Mesentery                                                       (3)                       (1)                                    
      Fat, Inflammation, Chronic                                    2 (67%)                                                         
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
      Acinus, Atrophy                                               3 (5%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05109-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
      Duct, Cyst                                                    1 (2%)                                                          
   Stomach, Forestomach                               (60)         (59)         (60)         (60)                                   
      Acanthosis                                       1 (2%)                    1 (2%)       1 (2%)                                
      Ulcer                                            2 (3%)                                                                       
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Dysplasia                                        2 (3%)                                                                       
      Hyperplasia                                                   1 (2%)                                                          
      Pigmentation                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Degeneration, Chronic                            1 (2%)       1 (2%)                    1 (2%)                                
      Atrium, Thrombosis                                                                      1 (2%)                                
      Coronary Artery, Polyarteritis, Chronic                       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Developmental Malformation                       1 (2%)                                 1 (2%)                                
      Hyperplasia                                      1 (2%)       2 (3%)       1 (2%)       3 (5%)                                
      Hypertrophy                                     17 (28%)     14 (23%)     16 (27%)      7 (12%)                               
      Necrosis                                                      1 (2%)                    2 (3%)                                
      Thrombosis                                                                 1 (2%)                                             
      Vacuolization Cytoplasmic                        7 (12%)      1 (2%)                    2 (3%)                                
      Capsule, Accessory Adrenal Cortical Nodule                    1 (2%)       2 (3%)       1 (2%)                                
      Capsule, Cyst                                                              1 (2%)                                             
      Capsule, Hyperplasia                                          1 (2%)                                                          
      Capsule, Spindle Cell, Hyperplasia              10 (17%)      4 (7%)       7 (12%)      4 (7%)                                
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Hyperplasia                                      2 (3%)       3 (5%)                    1 (2%)                                
      Necrosis                                                                                1 (2%)                                
   Parathyroid Gland                                  (55)         (52)         (56)         (54)                                   
      Cyst                                             1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (58)         (59)         (56)         (59)                                   
      Pars Distalis, Cyst                              2 (3%)       1 (2%)       1 (2%)       3 (5%)                                
      Pars Distalis, Hyperplasia                       2 (3%)       1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Polyarteritis, Chronic                                        1 (2%)                                                          
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                    14 (23%)     12 (20%)     10 (17%)      9 (15%)                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05109-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
      Granuloma Sperm                                  1 (2%)       2 (3%)       1 (2%)       2 (3%)                                
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
   Preputial Gland                                    (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic                            2 (3%)                    1 (2%)       2 (3%)                                
      Inflammation, Chronic Active                                               1 (2%)       2 (3%)                                
      Duct, Ectasia                                   36 (60%)     43 (72%)     31 (52%)     24 (40%)                               
   Prostate                                           (60)         (60)         (60)         (60)                                   
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                    1 (2%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
   Testes                                             (60)         (60)         (60)         (60)                                   
      Congestion                                                    1 (2%)                                                          
      Germinal Epithelium, Atrophy                     1 (2%)       1 (2%)                                                          
      Germinal Epithelium, Mineralization                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (59)         (58)         (59)                                   
      Myelofibrosis                                    1 (2%)       1 (2%)                                                          
   Lymph Node, Mandibular                             (57)         (57)         (57)         (57)                                   
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Lymph Node, Mesenteric                             (56)         (57)         (53)         (55)                                   
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)       3 (5%)       1 (2%)       1 (2%)                                
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Congestion                                                    1 (2%)                                                          
      Hematopoietic Cell Proliferation                 4 (7%)       6 (10%)      4 (7%)       8 (13%)                               
   Thymus                                             (53)         (46)         (57)         (52)                                   
      Atrophy                                         14 (26%)     25 (54%)     19 (33%)     16 (31%)                               
      Cyst                                                                                    1 (2%)                                
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05109-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)                                   
      Ulcer                                                                      2 (3%)                                             
      Hair Follicle, Sebaceous Gland, Site of                                                                                       
          Application-No Mass, Atrophy                                           1 (2%)      15 (25%)                               
      Inguinal, Acanthosis                                                                    1 (2%)                                
      Inguinal, Inflammation, Chronic                                                         2 (3%)                                
      Inguinal, Ulcer                                                                         1 (2%)                                
      Inguinal, Subcutaneous Tissue, Edema                                                    1 (2%)                                
      Site of Application-No Mass, Acanthosis          2 (3%)       2 (3%)       7 (12%)     17 (28%)                               
      Site of Application-No Mass, Inflammation,                                                                                    
           Chronic                                     2 (3%)                    9 (15%)     16 (27%)                               
      Site of Application-No Mass, Ulcer               1 (2%)                    2 (3%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (59)         (58)         (59)                                   
      Cranium, Hyperostosis                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Pons, Necrosis, Chronic, Focal                                1 (2%)                                                          
   Peripheral Nerve                                                (1)          (1)          (1)                                    
      Sciatic, Degeneration                                                      1 (100%)     1 (100%)                              
   Spinal Cord                                        (1)          (1)          (3)          (1)                                    
      Nerve, Degeneration                                                        1 (33%)      1 (100%)                              
      White Matter, Degeneration                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic                            1 (2%)                    2 (3%)                                             
      Alveolar Epithelium, Hyperplasia                 3 (5%)       4 (7%)       2 (3%)       2 (3%)                                
      Alveolar Epithelium, Hyperplasia, Macrophage     1 (2%)                                 1 (2%)                                
      Alveolus, Hemorrhage, Multifocal                 1 (2%)                                                                       
      Mediastinum, Infiltration Cellular,                                                                                           
          Histiocyte                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05109-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (3)          (1)                                                 
      Cornea, Inflammation, Chronic                                 3 (100%)                                                        
      Cornea, Inflammation, Chronic, Proliferative                               1 (100%)                                           
   Harderian Gland                                    (4)          (5)          (6)          (1)                                    
      Hyperplasia                                                                1 (17%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Hydronephrosis                                   2 (3%)                    1 (2%)                                             
      Metaplasia, Osseous                              1 (2%)                                                                       
      Mineralization                                                             1 (2%)                                             
      Nephropathy, Chronic                            55 (92%)     54 (90%)     55 (92%)     56 (93%)                               
      Cortex, Cyst                                                  4 (7%)       4 (7%)       2 (3%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
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