TDMS Study 05109-12 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TRIETHANOLAMINE DATE: 05/20/95
EXPERIMENT: 05109 TEST: 12 TIME: 00:27:28
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85226 ROUTE: DERMAL,SOLUTION NTP C#: 61621D
PATHOLOGIST: R. PERSING S. GRUMBEIN CAS: 102-71-6
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TRIETHANOLAMINE DATE: 05/20/95
EXPERIMENT: 05109 TEST: 12 TIME: 00:27:28
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85226 ROUTE: DERMAL,SOLUTION NTP C#: 61621D
PATHOLOGIST: R. PERSING S. GRUMBEIN CAS: 102-71-6
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 4 CENSORED DEATHS 10 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 367 616 678 712 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 10 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 515 537 621 665 666 667 682 683 688 716 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 630 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 10 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 373 493 507 540 607 645 652 670 677 694 |
| 697 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2000 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 9 CENSORED DEATHS 10 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 572 579 606 655 670 675 678 712 724 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 98.3 98.3 98.3 98.3 96.3 92.3 |
| | |
| | |
|200 | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 96.0 92.0 80.0 |
|MG/KG | |
| | |
|630 | 100.0 100.0 100.0 100.0 98.3 98.3 92.3 92.3 86.3 78.3 |
|MG/KG | |
| | |
|2000 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 92.0 82.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 200 630 2000 |
| MG/KG MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 92.3% 80.0% 78.3% 82.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.623 P=0.151 P=0.087 P=0.231 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 593.3 644.0 595.9 652.3 |
|NATURAL DEATHS (C) | (78.0) (21.1) (31.5) (18.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 674.5 669.3 659.1 672.0 |
|(STANDARD ERROR) | (14.2) (13.5) (14.6) (13.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 10 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 9 197 289 350 487 512 534 572 681 698 |
| 700 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 10 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 9 414 557 578 639 650 675 675 685 713 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 12 CENSORED DEATHS 10 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 320 434 540 579 597 603 624 669 674 682 |
| 712 716 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1000 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 10 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 317 415 521 537 551 591 647 661 670 680 |
| 699 712 712 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 98.3 98.3 96.7 93.3 93.3 93.3 87.2 85.2 85.2 79.1 |
| | |
| | |
|100 | 98.3 98.3 98.3 98.3 96.7 96.7 96.7 92.6 88.6 80.6 |
|MG/KG | |
| | |
|300 | 100.0 100.0 100.0 98.3 98.3 96.7 94.7 88.6 86.6 76.5 |
|MG/KG | |
| | |
|1000 | 100.0 100.0 100.0 98.3 96.7 96.7 92.6 88.6 84.6 74.5 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 100 300 1000 |
| MG/KG MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 79.1% 80.6% 76.5% 74.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.660 P=0.916N P=1.000 P=0.892 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 457.2 559.5 595.8 593.3 |
|NATURAL DEATHS (C) | (67.3) (67.1) (34.1) (33.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 633.8 655.4 657.0 654.3 |
|(STANDARD ERROR) | (20.6) (17.7) (15.0) (15.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRIETHANOLAMINE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
200 MG/KG = 2
630 MG/KG = 3
2000 MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.0 +1 13 2 4
|
|
| 13 3 2 2 44 1
97.5 +
|
| 3 3 2 4 412 1
|
95.0 +
| 3 3 1 1
P | 4 2 4 2
E |
R 92.5 + 3 3 1 1
C | 4 22
E |
N |
T 90.0 + 3 3 44
|
S |
U | 33 2 2
R 87.5 +
V |
I | 3 34 4
V |
A 85.0 +
L | 33
| 22 4 4
|
82.5 + 3 3
| 2 24 4
|
|
80.0 + 2 2
|
|
| 3 3
77.5 +
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.
TRIETHANOLAMINE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
100 MG/KG = 2
300 MG/KG = 3
1000 MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3
| 1 1 3 2 3
|
| 1 1 2 3 4 3 2
P 95 + 1 1 4 43 2 2
E | 1 1
R | 4 4 2 3 2
C | 1 1 4 433 22
E 90 +
N | 1 1 4 3 3 2 2
T | 1 1
| 3 4 43
S 85 + 1 4321
U | 1 1
R | 432 2
V |
I 80 + 3 4 2 2
V | 1 33 1
A |
L | 3 3
75 + 4 4
|
|
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 21 obs hidden.