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TDMS Study 05109-11 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          TRIETHANOLAMINE


NTP Experiment-Test: 05109-11                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  102-71-6

       Lock Date:  07/29/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05109-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      63 MG/KG     125          250                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                     14           17           13           15                                     
    Moribund Sacrifice                                11            4           12           17                                     
  Survivors                                                                                                                         
    Natural Death                                                                             1                                     
    Terminal Sacrifice                                25           29           25           17                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)                                   
      Perforation                                      2 (3%)                                                                       
   Intestine Large, Colon                             (60)         (60)         (60)         (60)                                   
      Parasite Metazoan                                2 (3%)       4 (7%)       3 (5%)       2 (3%)                                
   Intestine Large, Rectum                            (60)         (60)         (60)         (60)                                   
      Parasite Metazoan                                3 (5%)       8 (13%)      6 (10%)      8 (13%)                               
   Intestine Large, Cecum                             (60)         (60)         (60)         (60)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Small, Jejunum                           (60)         (60)         (60)         (60)                                   
      Necrosis, Coagulative                                                      1 (2%)                                             
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)       3 (5%)       3 (5%)                                             
      Basophilic Focus                                21 (35%)     28 (47%)     31 (52%)     11 (18%)                               
      Clear Cell Focus                                 1 (2%)       2 (3%)                                                          
      Eosinophilic Focus                               2 (3%)       1 (2%)       5 (8%)       5 (8%)                                
      Hepatodiaphragmatic Nodule                      11 (18%)     11 (18%)     12 (20%)      4 (7%)                                
      Inflammation, Chronic                           21 (35%)     22 (37%)     29 (48%)     23 (38%)                               
      Inflammation, Necrotizing                        1 (2%)       1 (2%)                                                          
      Mixed Cell Focus                                              2 (3%)       1 (2%)       1 (2%)                                
      Necrosis, Coagulative                            2 (3%)       1 (2%)                    2 (3%)                                
      Bile Duct, Hyperplasia                          16 (27%)     15 (25%)     18 (30%)     13 (22%)                               
      Hepatocyte, Vacuolization Cytoplasmic            3 (5%)       2 (3%)       5 (8%)       4 (7%)                                
      Kupffer Cell, Hypertrophy                                     1 (2%)                                                          
   Mesentery                                          (3)          (2)          (2)          (2)                                    
      Fat, Inflammation, Necrotizing                   2 (67%)      2 (100%)                                                        
      Perivascular, Inflammation, Chronic Active                                 1 (50%)      1 (50%)                               
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Acinus, Atrophy                                  5 (8%)       9 (15%)     17 (28%)      6 (10%)                               
      Artery, Inflammation, Chronic Active             1 (2%)                    1 (2%)                                             
      Duct, Ectasia                                    1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05109-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      63 MG/KG     125          250                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Perivascular, Inflammation, Chronic Active                                 1 (2%)                                             
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
      Duct, Ectasia                                                              1 (2%)                                             
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Inflammation, Necrotizing                        2 (3%)       4 (7%)       2 (3%)       3 (5%)                                
      Epithelium, Hyperplasia                          3 (5%)       2 (3%)       1 (2%)       3 (5%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Erosion                                          1 (2%)       3 (5%)       1 (2%)       1 (2%)                                
      Inflammation, Necrotizing                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (60)         (59)         (60)                                   
      Aorta, Polyarteritis, Chronic                                              1 (2%)                                             
      Mesenteric Artery, Polyarteritis, Chronic                                  1 (2%)                                             
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy, Chronic                         41 (68%)     33 (55%)     41 (68%)     36 (60%)                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Atrium, Thrombosis                               2 (3%)       3 (5%)                    4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Degeneration, Fatty                             15 (25%)     16 (27%)     19 (32%)     11 (18%)                               
      Hyperplasia                                     15 (25%)     21 (35%)     17 (28%)      6 (10%)                               
      Hypertrophy                                      2 (3%)                    2 (3%)       1 (2%)                                
      Karyomegaly                                                                1 (2%)                                             
      Necrosis, Coagulative                            1 (2%)                    1 (2%)                                             
   Adrenal Medulla                                    (60)         (60)         (60)         (59)                                   
      Hyperplasia                                      9 (15%)      8 (13%)      4 (7%)       4 (7%)                                
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Hyperplasia                                                                             1 (2%)                                
   Parathyroid Gland                                  (51)         (57)         (57)         (51)                                   
      Cyst                                                                       1 (2%)                                             
      Hyperplasia                                                                             1 (2%)                                
   Pituitary Gland                                    (60)         (60)         (60)         (60)                                   
      Craniopharyngeal Duct, Pars Distalis, Cyst       1 (2%)       1 (2%)                                                          
      Pars Distalis, Angiectasis                      37 (62%)     35 (58%)     36 (60%)     29 (48%)                               
      Pars Distalis, Cyst                             30 (50%)     22 (37%)     33 (55%)     20 (33%)                               
      Pars Distalis, Hyperplasia                      18 (30%)     24 (40%)     20 (33%)     15 (25%)                               
      Pars Distalis, Pigmentation, Hemosiderin        33 (55%)     29 (48%)     27 (45%)     22 (37%)                               
      Pars Intermedia, Cyst                            1 (2%)       1 (2%)                                                          
   Thyroid Gland                                      (60)         (60)         (60)         (59)                                   
      C-Cell, Hyperplasia                              8 (13%)      5 (8%)      10 (17%)      3 (5%)                                
      Follicle, Cyst                                                             1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05109-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      63 MG/KG     125          250                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicular Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (58)         (59)         (60)         (60)                                   
      Hyperplasia                                      3 (5%)       8 (14%)      4 (7%)       1 (2%)                                
      Inflammation, Chronic Active                    11 (19%)     19 (32%)     20 (33%)     10 (17%)                               
      Duct, Dilatation                                 2 (3%)       1 (2%)       4 (7%)       3 (5%)                                
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Atrophy                                          1 (2%)                                                                       
      Cyst                                             3 (5%)       4 (7%)       4 (7%)       2 (3%)                                
      Hematocyst                                       1 (2%)                                                                       
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Hyperplasia, Cystic, Glandular                   1 (2%)                                                                       
      Horn, Dilatation                                                                        3 (5%)                                
      Lumen, Hemorrhage                                1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hyperplasia                                      2 (3%)       3 (5%)       2 (3%)       5 (8%)                                
      Myelofibrosis                                                 1 (2%)                                                          
   Lymph Node                                         (6)          (5)          (6)          (3)                                    
      Mediastinal, Pigmentation, Hemosiderin                                     1 (17%)                                            
      Mediastinal, Sinus, Infiltration Cellular,                                                                                    
           Mononuclear Cell                                                      1 (17%)                                            
   Lymph Node, Mandibular                             (59)         (60)         (60)         (60)                                   
      Inflammation, Necrotizing                                     1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
      Sinus, Ectasia                                                             1 (2%)                                             
   Lymph Node, Mesenteric                             (60)         (60)         (59)         (60)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Fibrosis                                         2 (3%)                                 2 (3%)                                
      Hematopoietic Cell Proliferation                 2 (3%)       1 (2%)                    1 (2%)                                
      Infiltration Cellular, Lipocyte                               1 (2%)                                                          
      Red Pulp, Atrophy                                1 (2%)                    1 (2%)                                             
   Thymus                                             (59)         (57)         (57)         (58)                                   
      Fibrosis                                                                                1 (2%)                                
      Granuloma                                                                  1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05109-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      63 MG/KG     125          250                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (60)                                   
      Hyperplasia, Cystic                             47 (78%)     44 (73%)     50 (83%)     44 (73%)                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Skin                                               (60)         (60)         (60)         (60)                                   
      Epidermis, Site of Application-No Mass,                                                                                       
          Erosion                                      1 (2%)       6 (10%)     16 (27%)     14 (23%)                               
      Face, Abscess                                    1 (2%)                                                                       
      Head, Acanthosis                                                                        2 (3%)                                
      Head, Inflammation, Chronic Active               1 (2%)                                 2 (3%)                                
      Head, Ulcer                                                                             1 (2%)                                
      Inguinal, Acanthosis                             1 (2%)       1 (2%)                                                          
      Inguinal, Inflammation, Chronic Active           2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
      Site of Application-No Mass, Acanthosis          2 (3%)      11 (18%)     37 (62%)     38 (63%)                               
      Site of Application-No Mass, Inflammation,                                                                                    
           Chronic Active                              2 (3%)      11 (18%)     37 (62%)     38 (63%)                               
      Site of Application-No Mass, Ulcer                                         7 (12%)      9 (15%)                               
      Site of Application-No Mass, Ulcer, Multiple     2 (3%)       8 (13%)     22 (37%)     24 (40%)                               
      Tail, Acanthosis                                                                        1 (2%)                                
      Tail, Hyperkeratosis                                                                    1 (2%)                                
      Tail, Inflammation, Chronic Active                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteopetrosis                                                 3 (5%)       1 (2%)                                             
      Maxilla, Abscess                                              1 (2%)                                                          
   Skeletal Muscle                                    (1)                                    (2)                                    
      Fibrosis                                                                                1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                     18 (30%)     15 (25%)     15 (25%)     12 (20%)                               
      Hemorrhage                                       3 (5%)                                 1 (2%)                                
      Hydrocephalus                                   10 (17%)      9 (15%)     10 (17%)     13 (22%)                               
      Necrosis                                         1 (2%)                                                                       
   Peripheral Nerve                                   (2)                                    (1)                                    
      Sciatic, Myelin, Degeneration                                                           1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05109-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      63 MG/KG     125          250                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic Active                    16 (27%)     18 (30%)     17 (28%)     22 (37%)                               
      Inflammation, Necrotizing                                     1 (2%)                                                          
      Metaplasia, Osseous                                           1 (2%)                                                          
      Pigmentation, Hemosiderin                                                               1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 4 (7%)                    1 (2%)       1 (2%)                                
      Alveolus, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                        34 (57%)     43 (72%)     37 (62%)     34 (57%)                               
      Artery, Mediastinum, Polyarteritis, Chronic                                1 (2%)                                             
      Perivascular, Edema                                           1 (2%)                                                          
   Nose                                               (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic Active                     9 (15%)      5 (8%)       8 (13%)      1 (2%)                                
      Nasolacrimal Duct, Inflammation, Suppurative    11 (18%)      9 (15%)      9 (15%)      8 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (4)          (6)          (1)                                    
      Lens, Cataract                                   2 (100%)     3 (75%)      5 (83%)      1 (100%)                              
      Retina, Atrophy                                  2 (100%)     3 (75%)      6 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Nephropathy, Chronic                            54 (90%)     52 (87%)     49 (82%)     46 (77%)                               
      Cortex, Cyst                                                               2 (3%)                                             
      Renal Tubule, Hyperplasia                                                               1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05109-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      32 MG/KG     63 MG/KG     125                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           59           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      9           12            6            8                                     
    Moribund Sacrifice                                18           27           25           23                                     
    Accidently Killed                                  2                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                21           11           18           19                                     
  Animals Examined Microscopically                    60           60           59           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (60)         (59)         (60)                                   
      Inflammation, Necrotizing                        1 (2%)                                                                       
      Parasite Metazoan                                4 (7%)       5 (8%)       2 (3%)       3 (5%)                                
   Intestine Large, Rectum                            (60)         (60)         (59)         (60)                                   
      Parasite Metazoan                                6 (10%)      6 (10%)     11 (19%)      8 (13%)                               
   Intestine Large, Cecum                             (60)         (60)         (59)         (60)                                   
      Inflammation, Necrotizing                                     1 (2%)                                                          
      Inflammation, Suppurative                        2 (3%)                                                                       
      Parasite Metazoan                                             1 (2%)                                                          
   Intestine Small, Duodenum                          (60)         (60)         (59)         (60)                                   
      Inflammation, Necrotizing                        2 (3%)                                                                       
   Intestine Small, Ileum                             (60)         (60)         (59)         (60)                                   
      Parasite Metazoan                                             1 (2%)                                                          
   Liver                                              (60)         (60)         (59)         (60)                                   
      Angiectasis                                      1 (2%)                    2 (3%)                                             
      Basophilic Focus                                 7 (12%)      7 (12%)      4 (7%)      10 (17%)                               
      Clear Cell Focus                                 5 (8%)       4 (7%)       4 (7%)       1 (2%)                                
      Congestion                                                                              1 (2%)                                
      Eosinophilic Focus                               2 (3%)       4 (7%)       3 (5%)       2 (3%)                                
      Hepatodiaphragmatic Nodule                       4 (7%)       5 (8%)       7 (12%)      3 (5%)                                
      Hyperplasia, Nodular                                          1 (2%)                                                          
      Inflammation, Chronic                           12 (20%)     24 (40%)     19 (32%)     15 (25%)                               
      Leukocytosis                                                               1 (2%)                                             
      Mixed Cell Focus                                 1 (2%)       3 (5%)                    2 (3%)                                
      Necrosis, Coagulative                            1 (2%)       2 (3%)       2 (3%)       2 (3%)                                
      Bile Duct, Hyperplasia                          56 (93%)     49 (82%)     53 (90%)     52 (87%)                               
      Hepatocyte, Degeneration, Cystic                 8 (13%)      6 (10%)      6 (10%)      8 (13%)                               
      Hepatocyte, Vacuolization Cytoplasmic            6 (10%)      7 (12%)      5 (8%)       6 (10%)                               
   Mesentery                                          (9)          (10)         (11)         (5)                                    
      Fat, Inflammation, Necrotizing                   6 (67%)      7 (70%)      6 (55%)      4 (80%)                               
   Pancreas                                           (60)         (60)         (59)         (60)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05109-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      32 MG/KG     63 MG/KG     125                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Subacute                                                                  1 (2%)                                
      Acinus, Atrophy                                 23 (38%)     21 (35%)     19 (32%)     17 (28%)                               
      Acinus, Hyperplasia, Nodular                                  1 (2%)                    3 (5%)                                
      Artery, Inflammation, Chronic Active             1 (2%)       1 (2%)                    2 (3%)                                
      Artery, Thrombosis                               1 (2%)                                                                       
      Perivascular, Inflammation, Chronic Active                    1 (2%)                                                          
   Stomach, Forestomach                               (60)         (60)         (59)         (60)                                   
      Foreign Body, Multiple                           1 (2%)                                                                       
      Granuloma                                        1 (2%)                                                                       
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
      Inflammation, Necrotizing                        4 (7%)       3 (5%)       8 (14%)      6 (10%)                               
      Mineralization                                                1 (2%)                                                          
      Epithelium, Hyperplasia                          6 (10%)      6 (10%)      9 (15%)      5 (8%)                                
   Stomach, Glandular                                 (60)         (60)         (59)         (60)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Erosion                                          5 (8%)       3 (5%)       1 (2%)                                             
      Hyperplasia, Glandular                                                     1 (2%)                                             
      Inflammation, Necrotizing                        2 (3%)       2 (3%)       3 (5%)                                             
      Mineralization                                                1 (2%)                                                          
      Necrosis, Coagulative                                         1 (2%)       1 (2%)                                             
   Tongue                                             (1)                                                                           
      Cyst                                             1 (100%)                                                                     
   Tooth                                                           (1)                                                              
      Inflammation, Chronic Active                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (60)         (59)         (59)                                   
      Mineralization                                   1 (2%)       1 (2%)                                                          
      Mesenteric Artery, Polyarteritis, Chronic        1 (2%)                                                                       
      Mesenteric Artery, Thrombosis                                                           1 (2%)                                
   Heart                                              (60)         (60)         (59)         (60)                                   
      Cardiomyopathy, Chronic                         51 (85%)     52 (87%)     52 (88%)     55 (92%)                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Atrium, Thrombosis                               2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
      Endocardium, Atrium, Proliferation                                         1 (2%)                                             
      Valve, Bacterium                                              1 (2%)                                                          
      Valve, Inflammation, Chronic Active                           2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05109-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      32 MG/KG     63 MG/KG     125                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (59)         (60)                                   
      Accessory Adrenal Cortical Nodule                             1 (2%)                                                          
      Degeneration, Fatty                             21 (35%)     17 (28%)     20 (34%)     22 (37%)                               
      Hyperplasia                                     15 (25%)     17 (28%)     19 (32%)     24 (40%)                               
      Hypertrophy                                      7 (12%)      5 (8%)       6 (10%)      5 (8%)                                
      Karyomegaly                                                                             1 (2%)                                
      Necrosis, Coagulative                                                                   1 (2%)                                
   Adrenal Medulla                                    (60)         (60)         (59)         (60)                                   
      Hyperplasia                                     28 (47%)     22 (37%)     22 (37%)     21 (35%)                               
   Islets, Pancreatic                                 (60)         (60)         (59)         (60)                                   
      Hyperplasia                                      2 (3%)       3 (5%)                    1 (2%)                                
   Parathyroid Gland                                  (55)         (57)         (53)         (56)                                   
      Cyst                                                          1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia                                      3 (5%)       3 (5%)       3 (6%)       1 (2%)                                
   Pituitary Gland                                    (60)         (60)         (58)         (60)                                   
      Craniopharyngeal Duct, Pars Distalis, Cyst                                 1 (2%)                                             
      Pars Distalis, Angiectasis                      30 (50%)     36 (60%)     29 (50%)     39 (65%)                               
      Pars Distalis, Cyst                              4 (7%)       2 (3%)       3 (5%)       4 (7%)                                
      Pars Distalis, Hyperplasia                       9 (15%)     16 (27%)     15 (26%)     18 (30%)                               
      Pars Distalis, Infarct                           1 (2%)                    1 (2%)       1 (2%)                                
      Pars Distalis, Pigmentation, Hemosiderin        23 (38%)     24 (40%)     32 (55%)     35 (58%)                               
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
   Thyroid Gland                                      (60)         (60)         (59)         (60)                                   
      Cyst                                                                                    1 (2%)                                
      Hyperplasia                                                                1 (2%)                                             
      C-Cell, Hyperplasia                              8 (13%)      7 (12%)      8 (14%)      9 (15%)                               
      Follicle, Cyst                                   1 (2%)       1 (2%)                    1 (2%)                                
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Ectasia                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (59)         (60)                                   
      Atrophy                                         26 (43%)     25 (42%)     27 (46%)     20 (33%)                               
      Fibrosis                                                                                1 (2%)                                
      Granuloma Sperm                                                            1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Mineralization                                   1 (2%)       1 (2%)                                                          
      Fat, Necrosis                                                              1 (2%)                                             
   Preputial Gland                                    (60)         (60)         (58)         (60)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05109-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      32 MG/KG     63 MG/KG     125                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hyperplasia                                                   3 (5%)                                                          
      Inflammation, Chronic Active                    54 (90%)     53 (88%)     51 (88%)     58 (97%)                               
      Duct, Dilatation                                 5 (8%)       4 (7%)       5 (9%)       2 (3%)                                
   Prostate                                           (60)         (59)         (59)         (60)                                   
      Hyperplasia, Cystic                                                                     1 (2%)                                
      Inflammation, Chronic Active                    52 (87%)     52 (88%)     50 (85%)     56 (93%)                               
      Inflammation, Hemorrhagic                        1 (2%)                    1 (2%)                                             
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Seminal Vesicle                                    (60)         (60)         (59)         (60)                                   
      Atrophy                                         24 (40%)     22 (37%)     23 (39%)     13 (22%)                               
      Mineralization                                                1 (2%)                                                          
   Testes                                             (60)         (60)         (59)         (60)                                   
      Polyarteritis                                    9 (15%)      4 (7%)       9 (15%)      6 (10%)                               
      Interstitial Cell, Hyperplasia                  21 (35%)     22 (37%)     19 (32%)     25 (42%)                               
      Seminiferous Tubule, Atrophy                    10 (17%)      8 (13%)     14 (24%)      9 (15%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (59)         (60)                                   
      Hyperplasia                                      1 (2%)       3 (5%)       5 (8%)       4 (7%)                                
      Myelofibrosis                                                 1 (2%)       1 (2%)                                             
   Lymph Node                                         (15)         (10)         (16)         (9)                                    
      Inguinal, Sinus, Ectasia                                      1 (10%)                                                         
      Mediastinal, Sinus, Hemorrhage                                             1 (6%)                                             
   Lymph Node, Mandibular                             (60)         (60)         (59)         (60)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Necrosis, Coagulative                                         1 (2%)                                                          
   Lymph Node, Mesenteric                             (60)         (60)         (59)         (59)                                   
      Sinus, Ectasia                                   1 (2%)                                 1 (2%)                                
   Spleen                                             (60)         (60)         (59)         (60)                                   
      Congestion                                       1 (2%)                    1 (2%)                                             
      Developmental Malformation                                                 1 (2%)                                             
      Fibrosis                                        10 (17%)      3 (5%)       5 (8%)       7 (12%)                               
      Hematopoietic Cell Proliferation                              1 (2%)       2 (3%)       1 (2%)                                
      Necrosis, Coagulative                            3 (5%)       1 (2%)       2 (3%)       2 (3%)                                
      Thrombosis                                                                 1 (2%)                                             
      Red Pulp, Atrophy                                             1 (2%)                                                          
   Thymus                                             (56)         (59)         (58)         (59)                                   
      Cyst                                             1 (2%)                                                                       
      Developmental Malformation                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05109-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      32 MG/KG     63 MG/KG     125                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (53)         (54)         (54)                                   
      Cyst                                             1 (2%)                                                                       
      Hyperplasia, Cystic                             46 (79%)     37 (70%)     37 (69%)     42 (78%)                               
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (3%)       2 (4%)                    1 (2%)                                
      Inflammation, Proliferative                      1 (2%)                                 1 (2%)                                
   Skin                                               (60)         (60)         (59)         (60)                                   
      Dermis, Site of Application-No Mass, Fibrosis                 1 (2%)       1 (2%)       1 (2%)                                
      Dermis, Site of Application-Mass, Fibrosis       1 (2%)                                                                       
      Epidermis, Site of Application-No Mass,                                                                                       
          Erosion                                                                             1 (2%)                                
      Foot, Acanthosis                                 1 (2%)                                                                       
      Foot, Hyperkeratosis                             1 (2%)                                                                       
      Foot, Inflammation, Chronic Active               1 (2%)                                                                       
      Foot, Ulcer                                                   1 (2%)                                                          
      Inguinal, Acanthosis                             2 (3%)       1 (2%)       1 (2%)                                             
      Inguinal, Inflammation, Chronic Active                        2 (3%)       1 (2%)                                             
      Inguinal, Ulcer                                               1 (2%)                                                          
      Neck, Ventral, Inflammation, Chronic Active                                             1 (2%)                                
      Prepuce, Inflammation, Suppurative                                                      1 (2%)                                
      Site of Application-No Mass, Acanthosis          1 (2%)       1 (2%)       1 (2%)      11 (18%)                               
      Site of Application-No Mass, Inflammation,                                                                                    
           Chronic Active                                           2 (3%)                    8 (13%)                               
      Site of Application-No Mass, Ulcer                                                      4 (7%)                                
      Site of Application-No Mass, Ulcer, Multiple                                            1 (2%)                                
      Tail, Acanthosis                                                                        1 (2%)                                
      Tail, Hyperkeratosis                                                                    1 (2%)                                
      Tail, Inflammation, Chronic Active                            1 (2%)                    1 (2%)                                
      Tail, Ulcer                                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (59)         (60)                                   
      Fibrous Osteodystrophy                                        1 (2%)                    1 (2%)                                
      Femur, Cyst                                                                             1 (2%)                                
      Maxilla, Abscess                                 1 (2%)                    1 (2%)       1 (2%)                                
      Maxilla, Fibrosis                                2 (3%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (58)         (60)                                   
      Compression                                     15 (25%)     19 (32%)     10 (17%)     21 (35%)                               
      Gliosis                                          1 (2%)                                                                       
      Hemorrhage                                       1 (2%)       4 (7%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05109-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      32 MG/KG     63 MG/KG     125                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Hydrocephalus                                   14 (23%)     19 (32%)      9 (16%)     18 (30%)                               
   Peripheral Nerve                                   (2)                       (2)                                                 
      Sciatic, Myelin, Degeneration                                              1 (50%)                                            
   Spinal Cord                                        (2)                       (2)                                                 
      Hemorrhage                                                                 1 (50%)                                            
      White Matter, Degeneration                                                 1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (59)         (60)                                   
      Inflammation, Chronic Active                     8 (13%)      5 (8%)       6 (10%)      5 (8%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Metaplasia, Osseous                              1 (2%)                                                                       
      Mineralization                                                1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                              2 (3%)       3 (5%)       1 (2%)                                
      Alveolus, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                        17 (28%)     23 (38%)     20 (34%)     13 (22%)                               
      Fat, Mediastinum, Atrophy                                     1 (2%)                                                          
      Mediastinum, Fibrosis                                                                   1 (2%)                                
      Perivascular, Edema                              1 (2%)                                                                       
   Nose                                               (60)         (60)         (59)         (60)                                   
      Fungus                                           1 (2%)                                 1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic Active                     5 (8%)       4 (7%)       3 (5%)       9 (15%)                               
      Nasolacrimal Duct, Inflammation, Suppurative    12 (20%)     11 (18%)      8 (14%)      8 (13%)                               
      Respiratory Epithelium, Hyperplasia              2 (3%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (2)          (2)          (1)                                    
      Cyst Epithelial Inclusion                                     1 (50%)                                                         
   Eye                                                (3)                       (3)          (2)                                    
      Lens, Cataract                                   1 (33%)                   3 (100%)     2 (100%)                              
      Retina, Atrophy                                  1 (33%)                   3 (100%)     2 (100%)                              
   Zymbal's Gland                                                  (2)          (2)          (1)                                    
      Abscess                                                                    1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (59)         (60)                                   
      Hydronephrosis                                   1 (2%)       1 (2%)                                                          
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05109-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      32 MG/KG     63 MG/KG     125                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Necrosis, Coagulative                            1 (2%)       1 (2%)                                                          
      Nephropathy, Chronic                            58 (97%)     58 (97%)     59 (100%)    60 (100%)                              
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Cortex, Cyst                                     2 (3%)                    1 (2%)                                             
      Renal Tubule, Hyperplasia                                                               1 (2%)                                
   Urinary Bladder                                    (60)         (60)         (58)         (59)                                   
      Dilatation                                       1 (2%)                                                                       
      Inflammation, Hemorrhagic                        2 (3%)                                 1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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                             ----------              END OF REPORT             ----------                                           
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