TDMS Study 05109-11 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
TRIETHANOLAMINE
NTP Experiment-Test: 05109-11 Report: PEIRPT03
Study Type: CHRONIC Date: 05/19/95
Route: DERMAL,SOLUTION Time: 23:24:43
Facility: Battelle Columbus Laboratory
Chemical CAS #: 102-71-6
Lock Date: 07/29/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05109-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIETHANOLAMINE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 23:24:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 63 MG/KG 125 250
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Natural Death 14 17 13 15
Moribund Sacrifice 11 4 12 17
Survivors
Natural Death 1
Terminal Sacrifice 25 29 25 17
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (60) (60) (60)
Perforation 2 (3%)
Intestine Large, Colon (60) (60) (60) (60)
Parasite Metazoan 2 (3%) 4 (7%) 3 (5%) 2 (3%)
Intestine Large, Rectum (60) (60) (60) (60)
Parasite Metazoan 3 (5%) 8 (13%) 6 (10%) 8 (13%)
Intestine Large, Cecum (60) (60) (60) (60)
Inflammation, Suppurative 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Small, Jejunum (60) (60) (60) (60)
Necrosis, Coagulative 1 (2%)
Liver (60) (60) (60) (60)
Angiectasis 1 (2%) 3 (5%) 3 (5%)
Basophilic Focus 21 (35%) 28 (47%) 31 (52%) 11 (18%)
Clear Cell Focus 1 (2%) 2 (3%)
Eosinophilic Focus 2 (3%) 1 (2%) 5 (8%) 5 (8%)
Hepatodiaphragmatic Nodule 11 (18%) 11 (18%) 12 (20%) 4 (7%)
Inflammation, Chronic 21 (35%) 22 (37%) 29 (48%) 23 (38%)
Inflammation, Necrotizing 1 (2%) 1 (2%)
Mixed Cell Focus 2 (3%) 1 (2%) 1 (2%)
Necrosis, Coagulative 2 (3%) 1 (2%) 2 (3%)
Bile Duct, Hyperplasia 16 (27%) 15 (25%) 18 (30%) 13 (22%)
Hepatocyte, Vacuolization Cytoplasmic 3 (5%) 2 (3%) 5 (8%) 4 (7%)
Kupffer Cell, Hypertrophy 1 (2%)
Mesentery (3) (2) (2) (2)
Fat, Inflammation, Necrotizing 2 (67%) 2 (100%)
Perivascular, Inflammation, Chronic Active 1 (50%) 1 (50%)
Pancreas (60) (60) (60) (60)
Acinus, Atrophy 5 (8%) 9 (15%) 17 (28%) 6 (10%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
Duct, Ectasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05109-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIETHANOLAMINE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 23:24:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 63 MG/KG 125 250
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Perivascular, Inflammation, Chronic Active 1 (2%)
Salivary Glands (60) (60) (60) (60)
Duct, Ectasia 1 (2%)
Stomach, Forestomach (60) (60) (60) (60)
Inflammation, Necrotizing 2 (3%) 4 (7%) 2 (3%) 3 (5%)
Epithelium, Hyperplasia 3 (5%) 2 (3%) 1 (2%) 3 (5%)
Stomach, Glandular (60) (60) (60) (60)
Erosion 1 (2%) 3 (5%) 1 (2%) 1 (2%)
Inflammation, Necrotizing 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (60) (60) (59) (60)
Aorta, Polyarteritis, Chronic 1 (2%)
Mesenteric Artery, Polyarteritis, Chronic 1 (2%)
Heart (60) (60) (60) (60)
Cardiomyopathy, Chronic 41 (68%) 33 (55%) 41 (68%) 36 (60%)
Inflammation, Chronic Active 1 (2%)
Atrium, Thrombosis 2 (3%) 3 (5%) 4 (7%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Degeneration, Fatty 15 (25%) 16 (27%) 19 (32%) 11 (18%)
Hyperplasia 15 (25%) 21 (35%) 17 (28%) 6 (10%)
Hypertrophy 2 (3%) 2 (3%) 1 (2%)
Karyomegaly 1 (2%)
Necrosis, Coagulative 1 (2%) 1 (2%)
Adrenal Medulla (60) (60) (60) (59)
Hyperplasia 9 (15%) 8 (13%) 4 (7%) 4 (7%)
Islets, Pancreatic (60) (60) (60) (60)
Hyperplasia 1 (2%)
Parathyroid Gland (51) (57) (57) (51)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Pituitary Gland (60) (60) (60) (60)
Craniopharyngeal Duct, Pars Distalis, Cyst 1 (2%) 1 (2%)
Pars Distalis, Angiectasis 37 (62%) 35 (58%) 36 (60%) 29 (48%)
Pars Distalis, Cyst 30 (50%) 22 (37%) 33 (55%) 20 (33%)
Pars Distalis, Hyperplasia 18 (30%) 24 (40%) 20 (33%) 15 (25%)
Pars Distalis, Pigmentation, Hemosiderin 33 (55%) 29 (48%) 27 (45%) 22 (37%)
Pars Intermedia, Cyst 1 (2%) 1 (2%)
Thyroid Gland (60) (60) (60) (59)
C-Cell, Hyperplasia 8 (13%) 5 (8%) 10 (17%) 3 (5%)
Follicle, Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05109-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIETHANOLAMINE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 23:24:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 63 MG/KG 125 250
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (58) (59) (60) (60)
Hyperplasia 3 (5%) 8 (14%) 4 (7%) 1 (2%)
Inflammation, Chronic Active 11 (19%) 19 (32%) 20 (33%) 10 (17%)
Duct, Dilatation 2 (3%) 1 (2%) 4 (7%) 3 (5%)
Ovary (60) (60) (60) (60)
Atrophy 1 (2%)
Cyst 3 (5%) 4 (7%) 4 (7%) 2 (3%)
Hematocyst 1 (2%)
Uterus (60) (60) (60) (60)
Hyperplasia, Cystic, Glandular 1 (2%)
Horn, Dilatation 3 (5%)
Lumen, Hemorrhage 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Hyperplasia 2 (3%) 3 (5%) 2 (3%) 5 (8%)
Myelofibrosis 1 (2%)
Lymph Node (6) (5) (6) (3)
Mediastinal, Pigmentation, Hemosiderin 1 (17%)
Mediastinal, Sinus, Infiltration Cellular,
Mononuclear Cell 1 (17%)
Lymph Node, Mandibular (59) (60) (60) (60)
Inflammation, Necrotizing 1 (2%)
Inflammation, Suppurative 1 (2%)
Sinus, Ectasia 1 (2%)
Lymph Node, Mesenteric (60) (60) (59) (60)
Inflammation, Chronic Active 1 (2%)
Spleen (60) (60) (60) (60)
Fibrosis 2 (3%) 2 (3%)
Hematopoietic Cell Proliferation 2 (3%) 1 (2%) 1 (2%)
Infiltration Cellular, Lipocyte 1 (2%)
Red Pulp, Atrophy 1 (2%) 1 (2%)
Thymus (59) (57) (57) (58)
Fibrosis 1 (2%)
Granuloma 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05109-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIETHANOLAMINE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 23:24:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 63 MG/KG 125 250
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (60) (60) (60)
Hyperplasia, Cystic 47 (78%) 44 (73%) 50 (83%) 44 (73%)
Inflammation, Chronic Active 1 (2%)
Skin (60) (60) (60) (60)
Epidermis, Site of Application-No Mass,
Erosion 1 (2%) 6 (10%) 16 (27%) 14 (23%)
Face, Abscess 1 (2%)
Head, Acanthosis 2 (3%)
Head, Inflammation, Chronic Active 1 (2%) 2 (3%)
Head, Ulcer 1 (2%)
Inguinal, Acanthosis 1 (2%) 1 (2%)
Inguinal, Inflammation, Chronic Active 2 (3%) 1 (2%) 2 (3%) 1 (2%)
Site of Application-No Mass, Acanthosis 2 (3%) 11 (18%) 37 (62%) 38 (63%)
Site of Application-No Mass, Inflammation,
Chronic Active 2 (3%) 11 (18%) 37 (62%) 38 (63%)
Site of Application-No Mass, Ulcer 7 (12%) 9 (15%)
Site of Application-No Mass, Ulcer, Multiple 2 (3%) 8 (13%) 22 (37%) 24 (40%)
Tail, Acanthosis 1 (2%)
Tail, Hyperkeratosis 1 (2%)
Tail, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Osteopetrosis 3 (5%) 1 (2%)
Maxilla, Abscess 1 (2%)
Skeletal Muscle (1) (2)
Fibrosis 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 18 (30%) 15 (25%) 15 (25%) 12 (20%)
Hemorrhage 3 (5%) 1 (2%)
Hydrocephalus 10 (17%) 9 (15%) 10 (17%) 13 (22%)
Necrosis 1 (2%)
Peripheral Nerve (2) (1)
Sciatic, Myelin, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05109-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIETHANOLAMINE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 23:24:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 63 MG/KG 125 250
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Inflammation, Chronic Active 16 (27%) 18 (30%) 17 (28%) 22 (37%)
Inflammation, Necrotizing 1 (2%)
Metaplasia, Osseous 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (7%) 1 (2%) 1 (2%)
Alveolus, Infiltration Cellular, Mononuclear
Cell 34 (57%) 43 (72%) 37 (62%) 34 (57%)
Artery, Mediastinum, Polyarteritis, Chronic 1 (2%)
Perivascular, Edema 1 (2%)
Nose (60) (60) (60) (60)
Inflammation, Chronic Active 9 (15%) 5 (8%) 8 (13%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 11 (18%) 9 (15%) 9 (15%) 8 (13%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (4) (6) (1)
Lens, Cataract 2 (100%) 3 (75%) 5 (83%) 1 (100%)
Retina, Atrophy 2 (100%) 3 (75%) 6 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Nephropathy, Chronic 54 (90%) 52 (87%) 49 (82%) 46 (77%)
Cortex, Cyst 2 (3%)
Renal Tubule, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05109-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIETHANOLAMINE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 23:24:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 32 MG/KG 63 MG/KG 125
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 59 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Natural Death 9 12 6 8
Moribund Sacrifice 18 27 25 23
Accidently Killed 2
Survivors
Terminal Sacrifice 21 11 18 19
Animals Examined Microscopically 60 60 59 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (60) (60) (59) (60)
Inflammation, Necrotizing 1 (2%)
Parasite Metazoan 4 (7%) 5 (8%) 2 (3%) 3 (5%)
Intestine Large, Rectum (60) (60) (59) (60)
Parasite Metazoan 6 (10%) 6 (10%) 11 (19%) 8 (13%)
Intestine Large, Cecum (60) (60) (59) (60)
Inflammation, Necrotizing 1 (2%)
Inflammation, Suppurative 2 (3%)
Parasite Metazoan 1 (2%)
Intestine Small, Duodenum (60) (60) (59) (60)
Inflammation, Necrotizing 2 (3%)
Intestine Small, Ileum (60) (60) (59) (60)
Parasite Metazoan 1 (2%)
Liver (60) (60) (59) (60)
Angiectasis 1 (2%) 2 (3%)
Basophilic Focus 7 (12%) 7 (12%) 4 (7%) 10 (17%)
Clear Cell Focus 5 (8%) 4 (7%) 4 (7%) 1 (2%)
Congestion 1 (2%)
Eosinophilic Focus 2 (3%) 4 (7%) 3 (5%) 2 (3%)
Hepatodiaphragmatic Nodule 4 (7%) 5 (8%) 7 (12%) 3 (5%)
Hyperplasia, Nodular 1 (2%)
Inflammation, Chronic 12 (20%) 24 (40%) 19 (32%) 15 (25%)
Leukocytosis 1 (2%)
Mixed Cell Focus 1 (2%) 3 (5%) 2 (3%)
Necrosis, Coagulative 1 (2%) 2 (3%) 2 (3%) 2 (3%)
Bile Duct, Hyperplasia 56 (93%) 49 (82%) 53 (90%) 52 (87%)
Hepatocyte, Degeneration, Cystic 8 (13%) 6 (10%) 6 (10%) 8 (13%)
Hepatocyte, Vacuolization Cytoplasmic 6 (10%) 7 (12%) 5 (8%) 6 (10%)
Mesentery (9) (10) (11) (5)
Fat, Inflammation, Necrotizing 6 (67%) 7 (70%) 6 (55%) 4 (80%)
Pancreas (60) (60) (59) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05109-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIETHANOLAMINE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 23:24:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 32 MG/KG 63 MG/KG 125
MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Subacute 1 (2%)
Acinus, Atrophy 23 (38%) 21 (35%) 19 (32%) 17 (28%)
Acinus, Hyperplasia, Nodular 1 (2%) 3 (5%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (3%)
Artery, Thrombosis 1 (2%)
Perivascular, Inflammation, Chronic Active 1 (2%)
Stomach, Forestomach (60) (60) (59) (60)
Foreign Body, Multiple 1 (2%)
Granuloma 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Necrotizing 4 (7%) 3 (5%) 8 (14%) 6 (10%)
Mineralization 1 (2%)
Epithelium, Hyperplasia 6 (10%) 6 (10%) 9 (15%) 5 (8%)
Stomach, Glandular (60) (60) (59) (60)
Cyst Epithelial Inclusion 1 (2%)
Erosion 5 (8%) 3 (5%) 1 (2%)
Hyperplasia, Glandular 1 (2%)
Inflammation, Necrotizing 2 (3%) 2 (3%) 3 (5%)
Mineralization 1 (2%)
Necrosis, Coagulative 1 (2%) 1 (2%)
Tongue (1)
Cyst 1 (100%)
Tooth (1)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (60) (60) (59) (59)
Mineralization 1 (2%) 1 (2%)
Mesenteric Artery, Polyarteritis, Chronic 1 (2%)
Mesenteric Artery, Thrombosis 1 (2%)
Heart (60) (60) (59) (60)
Cardiomyopathy, Chronic 51 (85%) 52 (87%) 52 (88%) 55 (92%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
Atrium, Thrombosis 2 (3%) 1 (2%) 1 (2%) 1 (2%)
Endocardium, Atrium, Proliferation 1 (2%)
Valve, Bacterium 1 (2%)
Valve, Inflammation, Chronic Active 2 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05109-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIETHANOLAMINE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 23:24:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 32 MG/KG 63 MG/KG 125
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (59) (60)
Accessory Adrenal Cortical Nodule 1 (2%)
Degeneration, Fatty 21 (35%) 17 (28%) 20 (34%) 22 (37%)
Hyperplasia 15 (25%) 17 (28%) 19 (32%) 24 (40%)
Hypertrophy 7 (12%) 5 (8%) 6 (10%) 5 (8%)
Karyomegaly 1 (2%)
Necrosis, Coagulative 1 (2%)
Adrenal Medulla (60) (60) (59) (60)
Hyperplasia 28 (47%) 22 (37%) 22 (37%) 21 (35%)
Islets, Pancreatic (60) (60) (59) (60)
Hyperplasia 2 (3%) 3 (5%) 1 (2%)
Parathyroid Gland (55) (57) (53) (56)
Cyst 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 3 (5%) 3 (5%) 3 (6%) 1 (2%)
Pituitary Gland (60) (60) (58) (60)
Craniopharyngeal Duct, Pars Distalis, Cyst 1 (2%)
Pars Distalis, Angiectasis 30 (50%) 36 (60%) 29 (50%) 39 (65%)
Pars Distalis, Cyst 4 (7%) 2 (3%) 3 (5%) 4 (7%)
Pars Distalis, Hyperplasia 9 (15%) 16 (27%) 15 (26%) 18 (30%)
Pars Distalis, Infarct 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Pigmentation, Hemosiderin 23 (38%) 24 (40%) 32 (55%) 35 (58%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (60) (60) (59) (60)
Cyst 1 (2%)
Hyperplasia 1 (2%)
C-Cell, Hyperplasia 8 (13%) 7 (12%) 8 (14%) 9 (15%)
Follicle, Cyst 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Ectasia 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (60) (59) (60)
Atrophy 26 (43%) 25 (42%) 27 (46%) 20 (33%)
Fibrosis 1 (2%)
Granuloma Sperm 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%) 1 (2%)
Fat, Necrosis 1 (2%)
Preputial Gland (60) (60) (58) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05109-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIETHANOLAMINE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 23:24:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 32 MG/KG 63 MG/KG 125
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hyperplasia 3 (5%)
Inflammation, Chronic Active 54 (90%) 53 (88%) 51 (88%) 58 (97%)
Duct, Dilatation 5 (8%) 4 (7%) 5 (9%) 2 (3%)
Prostate (60) (59) (59) (60)
Hyperplasia, Cystic 1 (2%)
Inflammation, Chronic Active 52 (87%) 52 (88%) 50 (85%) 56 (93%)
Inflammation, Hemorrhagic 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Seminal Vesicle (60) (60) (59) (60)
Atrophy 24 (40%) 22 (37%) 23 (39%) 13 (22%)
Mineralization 1 (2%)
Testes (60) (60) (59) (60)
Polyarteritis 9 (15%) 4 (7%) 9 (15%) 6 (10%)
Interstitial Cell, Hyperplasia 21 (35%) 22 (37%) 19 (32%) 25 (42%)
Seminiferous Tubule, Atrophy 10 (17%) 8 (13%) 14 (24%) 9 (15%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (59) (60)
Hyperplasia 1 (2%) 3 (5%) 5 (8%) 4 (7%)
Myelofibrosis 1 (2%) 1 (2%)
Lymph Node (15) (10) (16) (9)
Inguinal, Sinus, Ectasia 1 (10%)
Mediastinal, Sinus, Hemorrhage 1 (6%)
Lymph Node, Mandibular (60) (60) (59) (60)
Hyperplasia, Lymphoid 1 (2%)
Necrosis, Coagulative 1 (2%)
Lymph Node, Mesenteric (60) (60) (59) (59)
Sinus, Ectasia 1 (2%) 1 (2%)
Spleen (60) (60) (59) (60)
Congestion 1 (2%) 1 (2%)
Developmental Malformation 1 (2%)
Fibrosis 10 (17%) 3 (5%) 5 (8%) 7 (12%)
Hematopoietic Cell Proliferation 1 (2%) 2 (3%) 1 (2%)
Necrosis, Coagulative 3 (5%) 1 (2%) 2 (3%) 2 (3%)
Thrombosis 1 (2%)
Red Pulp, Atrophy 1 (2%)
Thymus (56) (59) (58) (59)
Cyst 1 (2%)
Developmental Malformation 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05109-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIETHANOLAMINE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 23:24:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 32 MG/KG 63 MG/KG 125
MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (53) (54) (54)
Cyst 1 (2%)
Hyperplasia, Cystic 46 (79%) 37 (70%) 37 (69%) 42 (78%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 2 (3%) 2 (4%) 1 (2%)
Inflammation, Proliferative 1 (2%) 1 (2%)
Skin (60) (60) (59) (60)
Dermis, Site of Application-No Mass, Fibrosis 1 (2%) 1 (2%) 1 (2%)
Dermis, Site of Application-Mass, Fibrosis 1 (2%)
Epidermis, Site of Application-No Mass,
Erosion 1 (2%)
Foot, Acanthosis 1 (2%)
Foot, Hyperkeratosis 1 (2%)
Foot, Inflammation, Chronic Active 1 (2%)
Foot, Ulcer 1 (2%)
Inguinal, Acanthosis 2 (3%) 1 (2%) 1 (2%)
Inguinal, Inflammation, Chronic Active 2 (3%) 1 (2%)
Inguinal, Ulcer 1 (2%)
Neck, Ventral, Inflammation, Chronic Active 1 (2%)
Prepuce, Inflammation, Suppurative 1 (2%)
Site of Application-No Mass, Acanthosis 1 (2%) 1 (2%) 1 (2%) 11 (18%)
Site of Application-No Mass, Inflammation,
Chronic Active 2 (3%) 8 (13%)
Site of Application-No Mass, Ulcer 4 (7%)
Site of Application-No Mass, Ulcer, Multiple 1 (2%)
Tail, Acanthosis 1 (2%)
Tail, Hyperkeratosis 1 (2%)
Tail, Inflammation, Chronic Active 1 (2%) 1 (2%)
Tail, Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (59) (60)
Fibrous Osteodystrophy 1 (2%) 1 (2%)
Femur, Cyst 1 (2%)
Maxilla, Abscess 1 (2%) 1 (2%) 1 (2%)
Maxilla, Fibrosis 2 (3%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (58) (60)
Compression 15 (25%) 19 (32%) 10 (17%) 21 (35%)
Gliosis 1 (2%)
Hemorrhage 1 (2%) 4 (7%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05109-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIETHANOLAMINE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 23:24:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 32 MG/KG 63 MG/KG 125
MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Hydrocephalus 14 (23%) 19 (32%) 9 (16%) 18 (30%)
Peripheral Nerve (2) (2)
Sciatic, Myelin, Degeneration 1 (50%)
Spinal Cord (2) (2)
Hemorrhage 1 (50%)
White Matter, Degeneration 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (59) (60)
Inflammation, Chronic Active 8 (13%) 5 (8%) 6 (10%) 5 (8%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 1 (2%)
Mineralization 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (3%) 3 (5%) 1 (2%)
Alveolus, Infiltration Cellular, Mononuclear
Cell 17 (28%) 23 (38%) 20 (34%) 13 (22%)
Fat, Mediastinum, Atrophy 1 (2%)
Mediastinum, Fibrosis 1 (2%)
Perivascular, Edema 1 (2%)
Nose (60) (60) (59) (60)
Fungus 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 5 (8%) 4 (7%) 3 (5%) 9 (15%)
Nasolacrimal Duct, Inflammation, Suppurative 12 (20%) 11 (18%) 8 (14%) 8 (13%)
Respiratory Epithelium, Hyperplasia 2 (3%) 1 (2%)
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SPECIAL SENSES SYSTEM
Ear (1) (2) (2) (1)
Cyst Epithelial Inclusion 1 (50%)
Eye (3) (3) (2)
Lens, Cataract 1 (33%) 3 (100%) 2 (100%)
Retina, Atrophy 1 (33%) 3 (100%) 2 (100%)
Zymbal's Gland (2) (2) (1)
Abscess 1 (50%)
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URINARY SYSTEM
Kidney (60) (60) (59) (60)
Hydronephrosis 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05109-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIETHANOLAMINE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 23:24:43
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FISCHER 344 RATS MALE 0 MG/KG 32 MG/KG 63 MG/KG 125
MG/KG
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URINARY SYSTEM - CONT
Necrosis, Coagulative 1 (2%) 1 (2%)
Nephropathy, Chronic 58 (97%) 58 (97%) 59 (100%) 60 (100%)
Pigmentation, Hemosiderin 1 (2%)
Cortex, Cyst 2 (3%) 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Urinary Bladder (60) (60) (58) (59)
Dilatation 1 (2%)
Inflammation, Hemorrhagic 2 (3%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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