TDMS Study 05109-11 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TRIETHANOLAMINE DATE: 05/19/95
EXPERIMENT: 05109 TEST: 11 TIME: 23:42:56
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85226 ROUTE: DERMAL,SOLUTION NTP C#: 61621D
PATHOLOGIST: J. TOFF CAS: 102-71-6
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TRIETHANOLAMINE DATE: 05/19/95
EXPERIMENT: 05109 TEST: 11 TIME: 23:42:56
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85226 ROUTE: DERMAL,SOLUTION NTP C#: 61621D
PATHOLOGIST: J. TOFF CAS: 102-71-6
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 27 CENSORED DEATHS 12 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 12 452 535 536 538 550 554 554 577 586 |
| 589 591 609 618 621 631 642 654 656 670 |
| 670 670 702 705 705 705 710 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| 476 727 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 32 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 39 CENSORED DEATHS 10 TERMINAL 11 |
| |
| UNCENSORED DEATHS |
| 416 420 443 467 484 507 549 558 558 564 |
| 572 573 578 599 604 606 608 613 619 620 |
| 621 631 634 635 649 667 677 684 690 694 |
| 702 710 718 719 719 724 724 726 727 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 63 MG/KG |
| --------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 31 CENSORED DEATHS 10 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 353 365 379 431 500 522 562 574 575 579 |
| 584 586 616 617 623 631 631 634 642 649 |
| 652 702 702 710 710 710 719 722 724 724 |
| 724 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 125 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 31 CENSORED DEATHS 10 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 404 424 444 459 502 502 535 543 546 558 |
| 558 562 563 572 572 579 617 642 642 645 |
| 649 664 665 667 670 684 688 690 691 718 |
| 722 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 98.3 98.3 98.3 98.3 98.3 96.7 90.5 76.1 61.7 45.2 |
| | |
| | |
|32 MG/KG | 100.0 100.0 100.0 100.0 96.7 91.0 88.9 70.7 50.5 22.2 |
| | |
| | |
|63 MG/KG | 100.0 100.0 100.0 96.6 94.9 93.2 89.1 76.6 58.0 37.3 |
| | |
| | |
|125 | 100.0 100.0 100.0 100.0 96.7 93.0 84.9 68.7 54.6 38.4 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 32 MG/KG 63 MG/KG 125 |
| MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 45.2% 22.2% 37.3% 38.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.861 P=0.053 P=0.647 P=0.482 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 594.1 615.6 608.1 592.8 |
|NATURAL DEATHS (C) | (25.8) (14.2) (19.5) (15.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 618.6 609.8 619.2 613.1 |
|(STANDARD ERROR) | (17.1) (14.0) (15.7) (14.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 25 CENSORED DEATHS 10 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 338 390 466 542 555 567 582 593 634 636 |
| 638 639 663 671 674 674 691 699 710 710 |
| 713 718 719 719 728 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 63 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 10 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 400 434 443 504 536 562 576 579 583 595 |
| 600 649 662 664 673 678 691 699 708 715 |
| 727 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 125 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 25 CENSORED DEATHS 10 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 222 399 477 484 544 544 574 593 600 619 |
| 631 639 639 648 670 673 691 700 710 714 |
| 718 719 724 725 728 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 250 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 32 CENSORED DEATHS 10 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 125 250 353 353 358 389 394 420 429 439 |
| 459 463 522 524 556 588 588 610 617 624 |
| 631 633 644 649 657 667 670 670 690 700 |
| 713 718 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 98.3 96.7 94.7 92.6 84.6 74.5 50.3 |
| | |
| | |
|63 MG/KG | 100.0 100.0 100.0 100.0 98.3 95.0 91.0 78.8 72.8 58.6 |
| | |
| | |
|125 | 100.0 100.0 98.3 98.3 96.7 92.6 88.6 82.6 72.5 50.3 |
|MG/KG | |
| | |
|250 | 100.0 98.3 96.7 91.7 86.7 79.2 75.0 68.7 52.1 37.5 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 63 MG/KG 125 250 |
| MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 50.3% 58.6% 50.3% 37.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.018 P=0.659N P=1.000 P=0.057 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 626.8 603.7 615.4 534.5 |
|NATURAL DEATHS (C) | (20.8) (21.2) (24.1) (26.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 641.1 639.8 636.3 579.9 |
|(STANDARD ERROR) | (15.0) (14.9) (15.9) (19.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRIETHANOLAMINE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
32 MG/KG = 2
63 MG/KG = 3
125 MG/KG = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 4 2
| 1 3 3 3 4 24 2 1 1
| 3 3 2 42
| 3 42 2 3
90 + 2 32 3 1 1 3
| 441133
| 1 31
| 4 22 11
P 80 + 42231 1
E | 223 3
R | 442 12131
C | 22
E 70 + 44 1 1
N | 4 224 11
T | 22 31 1
| 331 1
S 60 + 33
U | 2 2 43 4 3
R | 41 13
V | 2 2
I 50 + 2 2 4
V | 2224 113
A | 22 133 1
L | 22 4
40 + 22 44
| 2223 3
|
|
30 + 22
|
|
| 2 2
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 39 obs hidden.
TRIETHANOLAMINE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
63 MG/KG = 2
125 MG/KG = 3
250 MG/KG = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.00 +1 4 3 1 2
| 4 3 4 1 132 2
| 4 4 13 2 2 1 3 2
| 44 1 33 2 21
91.67 + 4 4 3 21 11
| 44 3 1321
| 4 4 4 3 1 1
| 44 22 13 1
P 83.33 + 4 4 2 23 3
E | 44 22 3 11
R | 4 4 2 332
C | 12 1
E 75.00 + 4 4 33 11
N | 4 4 3 211
T | 33
| 4 4 1 1
S 66.67 + 44 11
U | 44 1 1
R | 44 22
V | 322
I 58.33 + 44 112 2
V | 44 33
A | 44
L | 4 4 11
50.00 + 1 1
|
| 4 4
| 44
41.67 + 4 4
| 44
| 4 4
|
33.33 +
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 30 obs hidden.