TDMS Study 05109-14 Pathology Tables
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
FINAL #1/MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 102-71-6
Lock Date: 05/31/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 5| 3| 3| 2| 3| 1| 6| 5| 3| 3| 6| 3| 3| 3| 2| 3| 2| 3| 1| 1| 3| 3|
| 0| 0| 9| 2| 1| 2| 9| 1| 9| 6| 7| 0| 1| 9| 1| 0| 1| 9| 1| 9| 0| 7| 7| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Necrosis | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 4 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X X X X X X |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 1 1 1 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | X |
Vacuolization Cytoplasmic, Focal | 2 2 1 1 1 1|
Centrilobular, Necrosis | 2 |
|__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic | 2 |
Fat, Necrosis | 2 2 3 2 |
Lymphatic, Angiectasis | 2 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 1 1 1 1 3 1 1 1 2 3 2 1 1|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 5| 3| 3| 2| 3| 1| 6| 5| 3| 3| 6| 3| 3| 3| 2| 3| 2| 3| 1| 1| 3| 3|
| 0| 0| 9| 2| 1| 2| 9| 1| 9| 6| 7| 0| 1| 9| 1| 0| 1| 9| 1| 9| 0| 7| 7| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Duct, Cyst | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Cyst | 1 |
Epithelium, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 2 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 1 1|
Atrium, Thrombosis | 4 |
Myocardium, Degeneration | 2 2 |
Myocardium, Inflammation, Acute | 1 |
Myocardium, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 1 |
Subcapsular, Hyperplasia | 2 2 1 2 1 1 2 2 2 2 2 2 2 2 1 2 1 2 2 2 1 1 2 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 1 2 1 1 1 3 2 1 1 2 1|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 5| 3| 3| 2| 3| 1| 6| 5| 3| 3| 6| 3| 3| 3| 2| 3| 2| 3| 1| 1| 3| 3|
| 0| 0| 9| 2| 1| 2| 9| 1| 9| 6| 7| 0| 1| 9| 1| 0| 1| 9| 1| 9| 0| 7| 7| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Parathyroid Gland | + + + + + + M + + + + M M + M + + + M + M M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 1 |
Follicle, Cyst | 2 |
Follicular Cell, Necrosis | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 1 |
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 2 1 1 2 1 1 3 2 1 1 1 2|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 1 3 2 3 2 3 2 2 4 1 2 2 4 2 2 1 2 1 3 1 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | |
|__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Hyperplasia, Lymphoid | 3 |
Lumbar, Inflammation, Acute | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 5| 3| 3| 2| 3| 1| 6| 5| 3| 3| 6| 3| 3| 3| 2| 3| 2| 3| 1| 1| 3| 3|
| 0| 0| 9| 2| 1| 2| 9| 1| 9| 6| 7| 0| 1| 9| 1| 0| 1| 9| 1| 9| 0| 7| 7| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 1 3 2 1 3 1 1 2 1 4 1 1 2 4 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 3 3 4 2 |
Hyperplasia, Focal | 2 |
Hyperplasia, Histiocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Dilatation | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperkeratosis | 1 |
Epidermis, Hyperplasia | 1 |
Epidermis, Inflammation, Suppurative | 2 |
Epidermis, Ulcer | 4 |
Site of Application - Epidermis, | |
Hyperkeratosis | 1 1 1 |
Site of Application - Epidermis, | |
Hyperplasia | 1 1 1 1 1 4 1|
Site of Application - Epidermis, | |
Inflammation, Suppurative | 2 |
Site of Application - Epidermis, | |
Ulcer | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 4 |
Subcutaneous Tissue, Necrosis | |
Subcutaneous Tissue, Site of | |
Application - Dermis, | |
Inflammation, Chronic | 1 4 1 |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 5| 3| 3| 2| 3| 1| 6| 5| 3| 3| 6| 3| 3| 3| 2| 3| 2| 3| 1| 1| 3| 3|
| 0| 0| 9| 2| 1| 2| 9| 1| 9| 6| 7| 0| 1| 9| 1| 0| 1| 9| 1| 9| 0| 7| 7| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 1 1 |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Inflammation, Granulomatous | 1 |
Bronchus, Hyperplasia, Focal | |
Bronchus, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1|
Papilla, Necrosis | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 5| 3| 3| 2| 3| 1| 6| 5| 3| 3| 6| 3| 3| 3| 2| 3| 2| 3| 1| 1| 3| 3|
| 0| 0| 9| 2| 1| 2| 9| 1| 9| 6| 7| 0| 1| 9| 1| 0| 1| 9| 1| 9| 0| 7| 7| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 2| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 9| 2| 2| 3| 3| 3| 3| 3| 3| |
| 1| 3| 1| 0| 9| 0| 0| 9| 0| 1| 1| 7| 1| 0| 1| 0| 5| 9| 9| 0| 1| 1| 0| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Necrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 4 |
Clear Cell Focus | X | 4 |
Eosinophilic Focus | X X X X X X X X | 16 |
Fibrosis, Focal | 2 | 1 2.0|
Hematopoietic Cell Proliferation | X | 4 1.0|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 26 1.0|
Inflammation, Chronic | 1 1 1 1 1 | 14 1.0|
Mixed Cell Focus | X X X X| 5 |
Vacuolization Cytoplasmic, Focal | 1 1 | 8 1.3|
Centrilobular, Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 11 |
Inflammation, Chronic | | 1 2.0|
Fat, Necrosis | 2 2 4 3 2 3 | 10 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 2| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 9| 2| 2| 3| 3| 3| 3| 3| 3| |
| 1| 3| 1| 0| 9| 0| 0| 9| 0| 1| 1| 7| 1| 0| 1| 0| 5| 9| 9| 0| 1| 1| 0| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Lymphatic, Angiectasis | | 1 2.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + +| 26 |
Inflammation, Chronic | 1 1 2 1 2 2 2 1 1 1 2| 26 1.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 4 | 1 4.0|
Duct, Cyst | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Cyst | | 1 1.0|
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic | 1 | 3 1.0|
Atrium, Thrombosis | 4 | 2 4.0|
Myocardium, Degeneration | 2 2 | 4 2.0|
Myocardium, Inflammation, Acute | | 1 1.0|
Myocardium, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 2| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 9| 2| 2| 3| 3| 3| 3| 3| 3| |
| 1| 3| 1| 0| 9| 0| 0| 9| 0| 1| 1| 7| 1| 0| 1| 0| 5| 9| 9| 0| 1| 1| 0| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia, Focal | | 1 1.0|
Subcapsular, Hyperplasia | 2 1 2 2 1 1 2 2 1 2 2 2 1 2 2 2 2 1 1 2 2 2 2 2 2| 49 1.7|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 1 1 1 1 1 2 | 25 1.3|
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + M + + + + + + + + + M M + + + +| 39 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 1 1 1 3 1 1 1 2 | 11 1.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | | 1 1.0|
Follicle, Cyst | | 1 2.0|
Follicular Cell, Necrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 1.0|
Inflammation, Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 2 2.0|
Cyst | 1 1 2 3 3 1 1 3 1 2 4 2 2 1 1| 27 1.7|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 4 2 2 3 1 3 3 3 3 4 1 1 3 3 3 1 3 3 4 3 2 3 4 3| 49 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 2| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 9| 2| 2| 3| 3| 3| 3| 3| 3| |
| 1| 3| 1| 0| 9| 0| 0| 9| 0| 1| 1| 7| 1| 0| 1| 0| 5| 9| 9| 0| 1| 1| 0| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 6 |
Lumbar, Hyperplasia, Lymphoid | | 1 3.0|
Lumbar, Inflammation, Acute | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 4 1 1 2 1 3 1 3 1 2 2 2 1 1| 32 1.8|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Atrophy | 3 4 4 1 2 1 2 | 13 2.5|
Hyperplasia, Focal | | 1 2.0|
Hyperplasia, Histiocytic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Dilatation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Hyperkeratosis | | 1 1.0|
Epidermis, Hyperplasia | | 1 1.0|
Epidermis, Inflammation, Suppurative | | 1 2.0|
Epidermis, Ulcer | | 1 4.0|
Site of Application - Epidermis, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 2| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 9| 2| 2| 3| 3| 3| 3| 3| 3| |
| 1| 3| 1| 0| 9| 0| 0| 9| 0| 1| 1| 7| 1| 0| 1| 0| 5| 9| 9| 0| 1| 1| 0| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Hyperkeratosis | | 3 1.0|
Site of Application - Epidermis, | | |
Hyperplasia | 1 2 1 1 1 1 1 | 14 1.3|
Site of Application - Epidermis, | | |
Inflammation, Suppurative | | 1 2.0|
Site of Application - Epidermis, | | |
Ulcer | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 4.0|
Subcutaneous Tissue, Necrosis | 2 | 1 2.0|
Subcutaneous Tissue, Site of | | |
Application - Dermis, | | |
Inflammation, Chronic | 1 | 4 1.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 1 2 1 | 7 1.1|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Chronic | 1 | 2 1.0|
Inflammation, Granulomatous | | 1 1.0|
Bronchus, Hyperplasia, Focal | 1| 1 1.0|
Bronchus, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 2| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 9| 2| 2| 3| 3| 3| 3| 3| 3| |
| 1| 3| 1| 0| 9| 0| 0| 9| 0| 1| 1| 7| 1| 0| 1| 0| 5| 9| 9| 0| 1| 1| 0| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Degeneration | | 1 1.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Hyperplasia | 2 1 | 4 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 24 1.0|
Papilla, Necrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 2| 7| 6| 7| 7| 7| 6| 7| 6| 5| 6|
DAY ON TEST | 3| 3| 2| 2| 3| 1| 3| 3| 1| 3| 3| 3| 3| 2| 3| 2| 6| 3| 2| 2| 8| 2| 6| 9| 6|
| 1| 0| 9| 9| 0| 0| 0| 1| 0| 0| 0| 1| 1| 9| 9| 9| 5| 1| 9| 9| 6| 9| 5| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X X X X X X X X |
Hematopoietic Cell Proliferation | 3 1|
Hepatodiaphragmatic Nodule | X |
Infiltration Cellular, Lymphoid | 2 1 1 1 2 1 1 1 2 1 1 2 1 1 1 1 1 |
Inflammation, Chronic | 1 2 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | X X X |
Necrosis, Focal | 1 1 |
Vacuolization Cytoplasmic, Focal | |
|__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 2 2 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + |
Inflammation, Chronic | 3 1 2 2 2 1 1 2 1 2 2 1 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 2| 7| 6| 7| 7| 7| 6| 7| 6| 5| 6|
DAY ON TEST | 3| 3| 2| 2| 3| 1| 3| 3| 1| 3| 3| 3| 3| 2| 3| 2| 6| 3| 2| 2| 8| 2| 6| 9| 6|
| 1| 0| 9| 9| 0| 0| 0| 1| 0| 0| 0| 1| 1| 9| 9| 9| 5| 1| 9| 9| 6| 9| 5| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Duct, Cyst | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2|
Ulcer | 1|
Epithelium, Hyperplasia, Focal | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 1 |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Hypertrophy, Focal | |
Subcapsular, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 3 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 3 1 1 2 2 2 1|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M M M + + + M M + + + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 2| 7| 6| 7| 7| 7| 6| 7| 6| 5| 6|
DAY ON TEST | 3| 3| 2| 2| 3| 1| 3| 3| 1| 3| 3| 3| 3| 2| 3| 2| 6| 3| 2| 2| 8| 2| 6| 9| 6|
| 1| 0| 9| 9| 0| 0| 0| 1| 0| 0| 0| 1| 1| 9| 9| 9| 5| 1| 9| 9| 6| 9| 5| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Intermedia, Hyperplasia | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 3 3 1 1 2 1 |
Thrombosis | 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 3 2 2 3 3 2 3 2 2 3 2 1 2 1 3 2 4 3 3 3 4 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + M + + +|
Deep Cervical, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 2 3 1 1 1 2 1 2 1 2 |
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 2| 7| 6| 7| 7| 7| 6| 7| 6| 5| 6|
DAY ON TEST | 3| 3| 2| 2| 3| 1| 3| 3| 1| 3| 3| 3| 3| 2| 3| 2| 6| 3| 2| 2| 8| 2| 6| 9| 6|
| 1| 0| 9| 9| 0| 0| 0| 1| 0| 0| 0| 1| 1| 9| 9| 9| 5| 1| 9| 9| 6| 9| 5| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +|
Atrophy | 3 2 2 2 2 2 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Site of Application - Epidermis, | |
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2|
Site of Application - Epidermis, | |
Inflammation, Suppurative | |
Site of Application - Epidermis, | |
Ulcer | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Site of | |
Application - Dermis, | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 2 3 |
Hyperostosis | |
Femur, Hyperostosis | |
|__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Meninges, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 2| 7| 6| 7| 7| 7| 6| 7| 6| 5| 6|
DAY ON TEST | 3| 3| 2| 2| 3| 1| 3| 3| 1| 3| 3| 3| 3| 2| 3| 2| 6| 3| 2| 2| 8| 2| 6| 9| 6|
| 1| 0| 9| 9| 0| 0| 0| 1| 0| 0| 0| 1| 1| 9| 9| 9| 5| 1| 9| 9| 6| 9| 5| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Mineralization | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Infarct | 2 1 1 |
Nephropathy | 1 1 1 1 1 1 1 1 |
Glomerulus, Amyloid Deposition | 2 |
Papilla, Necrosis | |
Renal Tubule, Cytoplasmic Alteration | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 18
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 0| 7| 0| 3| 3| 3| 7| 3| 3| 3| 7| 2| 3| 3| 9| |
| 1| 1| 0| 1| 0| 1| 4| 1| 0| 1| 1| 4| 8| 0| 0| 1| 4| 0| 0| 1| 4| 1| 1| 1| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X X | 3 |
Eosinophilic Focus | X X X X X X X X | 22 |
Hematopoietic Cell Proliferation | 1 | 3 1.7|
Hepatodiaphragmatic Nodule | 1 | 2 1.0|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 2 2 1 1 | 30 1.2|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0|
Mixed Cell Focus | X X X X X | 8 |
Necrosis, Focal | 2 2 1 | 5 1.4|
Vacuolization Cytoplasmic, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Fat, Necrosis | 2 2 2 | 6 2.2|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + + + + | 26 |
Inflammation, Chronic | 1 3 1 3 1 1 2 1 1 2 3 1 2 | 26 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 0| 7| 0| 3| 3| 3| 7| 3| 3| 3| 7| 2| 3| 3| 9| |
| 1| 1| 0| 1| 0| 1| 4| 1| 0| 1| 1| 4| 8| 0| 0| 1| 4| 0| 0| 1| 4| 1| 1| 1| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 4 3 3 | 3 3.3|
Acinus, Hyperplasia | | 1 2.0|
Duct, Cyst | 4 3 | 2 3.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 2.0|
Ulcer | | 1 1.0|
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | 3 3| 2 3.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic | | 1 1.0|
Myocardium, Mineralization | 3 2| 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 1.0|
Hypertrophy, Focal | 2 2 | 2 2.0|
Subcapsular, Hyperplasia | 2 2 2 2 2 2 1 2 2 3 2 1 1 2 2 4 2 2 2 2 2 2 2 2 2| 49 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 0| 7| 0| 3| 3| 3| 7| 3| 3| 3| 7| 2| 3| 3| 9| |
| 1| 1| 0| 1| 0| 1| 4| 1| 0| 1| 1| 4| 8| 0| 0| 1| 4| 0| 0| 1| 4| 1| 1| 1| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 3 1 1 1 1 2 1 | 18 1.4|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + M + + + + M + + + + +| 41 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 2 2 | 3 2.0|
Pars Intermedia, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 2 1 1 3 1 3 2 3 2 3 1 3 | 22 2.0|
Thrombosis | | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 2 | 2 2.5|
Thrombosis | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 2 3 3 2 2 2 3 3 2 3 2 2 3 3 1 2 3 3 1 1 2 2 1| 48 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + | 7 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 0| 7| 0| 3| 3| 3| 7| 3| 3| 3| 7| 2| 3| 3| 9| |
| 1| 1| 0| 1| 0| 1| 4| 1| 0| 1| 1| 4| 8| 0| 0| 1| 4| 0| 0| 1| 4| 1| 1| 1| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Deep Cervical, Hyperplasia, Lymphoid | 4 | 1 4.0|
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 4| 2 3.0|
Hematopoietic Cell Proliferation | 1 3 1 1 2 1 1 1 1 2 2 1 2 | 24 1.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 4 3 3 2 4 2 4 2 4| 17 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Site of Application - Epidermis, | | |
Hyperplasia | 1 2 2 2 2 1 1 2 2 1 2 2 2 2 2 2 2 4 2 2 2 1 2 2 1| 50 1.9|
Site of Application - Epidermis, | | |
Inflammation, Suppurative | 1 3 | 2 2.0|
Site of Application - Epidermis, | | |
Ulcer | 3 | 1 3.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
Subcutaneous Tissue, Site of | | |
Application - Dermis, | | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 4 1 1 1 1 | 27 1.1|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 0| 7| 0| 3| 3| 3| 7| 3| 3| 3| 7| 2| 3| 3| 9| |
| 1| 1| 0| 1| 0| 1| 4| 1| 0| 1| 1| 4| 8| 0| 0| 1| 4| 0| 0| 1| 4| 1| 1| 1| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 2 | 6 2.0|
Hyperostosis | 2 | 1 2.0|
Femur, Hyperostosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Meninges, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 2| 2 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 0| 7| 0| 3| 3| 3| 7| 3| 3| 3| 7| 2| 3| 3| 9| |
| 1| 1| 0| 1| 0| 1| 4| 1| 0| 1| 1| 4| 8| 0| 0| 1| 4| 0| 0| 1| 4| 1| 1| 1| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Infarct | 2 1 | 5 1.4|
Nephropathy | 1 1 1 1 1 3 1 1 1 1| 18 1.1|
Glomerulus, Amyloid Deposition | 4 | 2 3.0|
Papilla, Necrosis | 2| 1 2.0|
Renal Tubule, Cytoplasmic Alteration | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 6| 3| 7| 2| 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 0| 9| 9| 2| 0| 4| 9| 0| 1| 4| 1| 1| 0| 0| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Inflammation, | |
Suppurative | 3 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 1 |
Basophilic Focus | X X |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X X X X X X X X X X X X |
Hematopoietic Cell Proliferation | 2 1|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 2 2 1 1 1 1 1 2 1 2 1 1 1 1 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X X X X X |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Focal | 1 1 1 1 |
Centrilobular, Cytomegaly, Diffuse | |
Centrilobular, Necrosis | 3 |
|__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 2 2 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 6| 3| 7| 2| 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 0| 9| 9| 2| 0| 4| 9| 0| 1| 4| 1| 1| 0| 0| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Inflammation, Chronic | 2 2 2 2 1 2 2 2 1 2 2 1 2 2 2 1|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Duct, Cyst | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Epithelium, Mineralization | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Epithelium, Cyst | 1 |
Epithelium, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Tooth | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
Myocardium, Degeneration | |
Myocardium, Inflammation, Chronic | |
Myocardium, Necrosis | |
Pericardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | |
Inflammation, Suppurative | |
Subcapsular, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 6| 3| 7| 2| 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 0| 9| 9| 2| 0| 4| 9| 0| 1| 4| 1| 1| 0| 0| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Infiltration Cellular, Histiocyte | 2|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 1 1 1 4 1 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + M M + + + + + + + + + + + M + + + +|
Cyst | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Pars Distalis, Hyperplasia | 1 2 2 2|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 1 |
Follicle, Cyst | 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 3 3 2 2 3 3 3 4 1 2 1 1 4|
Thrombosis | 4 4 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Thrombosis | 4 |
Endometrium, Hyperplasia, Cystic | 3 3 3 2 4 4 2 2 3 3 2 2 2 4 1 3 2 3 2 3 4 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 6| 3| 7| 2| 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 0| 9| 9| 2| 0| 4| 9| 0| 1| 4| 1| 1| 0| 0| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
|__________________________________________________________________________|
Lymph Node | + + |
Iliac, Hyperplasia, Lymphoid | 4 |
Lumbar, Hyperplasia, Lymphoid | 4 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 4|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 3 |
|__________________________________________________________________________|
Spleen | + + + + M + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 1 1 1 2 2 2 2 3 1 1 2 2 2 1 2 1 1|
Hyperplasia, Lymphoid | 1 |
|__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 3 2 4 1 2 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Dilatation | 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Site of Application - Epidermis, | |
Hyperplasia | 1 2 2 2 1 3 2 2 1 2 1 1 2 3 3 3 3 2 1 2 1 1 2 2|
Site of Application - Epidermis, | |
Inflammation, Suppurative | 1 2 2 1 1 1 2 2 3 |
Site of Application - Epidermis, | |
Ulcer | 1 1 2 1 |
Subcutaneous Tissue, Site of | |
Application - Dermis, | |
Inflammation, Chronic | 1 2 2 2 1 1 1 2 2 2 3 2 1 2 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 6| 3| 7| 2| 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 0| 9| 9| 2| 0| 4| 9| 0| 1| 4| 1| 1| 0| 0| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 2 2 1 1 1 1 |
Cranium, Callus | 2 |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 1 |
Artery, Inflammation, Chronic | |
Hypothalamus, Compression | 4 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
Mediastinum, Inflammation, Chronic | |
Serosa, Inflammation, Chronic | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 |
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 6| 3| 7| 2| 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 0| 9| 9| 2| 0| 4| 9| 0| 1| 4| 1| 1| 0| 0| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 1 1|
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Inflammation, Granulomatous | |
Renal Tubule, Cyst | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 30
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| |
DAY ON TEST | 4| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 8| 2| 3| 3| 2| 3| 3| 3| |
| 7| 3| 0| 0| 0| 0| 0| 1| 9| 1| 1| 2| 0| 1| 1| 1| 0| 6| 9| 1| 0| 9| 1| 8| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
300 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + M + + M + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Serosa, Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Inflammation, | | |
Suppurative | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | | 1 1.0|
Basophilic Focus | X | 3 |
Clear Cell Focus | | 3 |
Eosinophilic Focus | X X X X X X X X X X X X X X | 28 |
Hematopoietic Cell Proliferation | 2 | 3 1.7|
Infiltration Cellular, Lymphoid | 1 2 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1| 36 1.2|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 | 22 1.0|
Mixed Cell Focus | X X X X X X X| 14 |
Necrosis, Focal | 1 | 1 1.0|
Vacuolization Cytoplasmic, Focal | 1 1 | 6 1.0|
Centrilobular, Cytomegaly, Diffuse | 3 | 1 3.0|
Centrilobular, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| |
DAY ON TEST | 4| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 8| 2| 3| 3| 2| 3| 3| 3| |
| 7| 3| 0| 0| 0| 0| 0| 1| 9| 1| 1| 2| 0| 1| 1| 1| 0| 6| 9| 1| 0| 9| 1| 8| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
300 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + | 4 |
Fat, Necrosis | | 3 2.3|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + + + + + +| 31 |
Inflammation, Chronic | 1 2 1 1 3 1 1 2 2 2 2 2 1 3 1| 31 1.7|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 | 1 2.0|
Duct, Cyst | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 1 | 2 1.5|
Epithelium, Mineralization | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 1.0|
Epithelium, Cyst | | 1 1.0|
Epithelium, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Inflammation, Chronic | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic | 1 3 | 2 2.0|
Myocardium, Degeneration | 3 | 1 3.0|
Myocardium, Inflammation, Chronic | 1 | 1 1.0|
Myocardium, Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| |
DAY ON TEST | 4| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 8| 2| 3| 3| 2| 3| 3| 3| |
| 7| 3| 0| 0| 0| 0| 0| 1| 9| 1| 1| 2| 0| 1| 1| 1| 0| 6| 9| 1| 0| 9| 1| 8| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
300 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Pericardium, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy, Focal | 1 | 1 1.0|
Inflammation, Suppurative | 1 | 1 1.0|
Subcapsular, Hyperplasia | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 1 2| 50 1.9|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 3 2 2 2 2 1 | 20 1.5|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 45 |
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Pars Distalis, Hyperplasia | 1 3 2 2 1 | 9 1.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | | 1 1.0|
Follicle, Cyst | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| |
DAY ON TEST | 4| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 8| 2| 3| 3| 2| 3| 3| 3| |
| 7| 3| 0| 0| 0| 0| 0| 1| 9| 1| 1| 2| 0| 1| 1| 1| 0| 6| 9| 1| 0| 9| 1| 8| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
300 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Cyst | 1 1 1 2 1 1 1 2| 21 2.0|
Thrombosis | 4 | 3 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 3 | 2 3.0|
Thrombosis | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 1 1 1 3 4 2 2 4 3 4 2 4 4 3 3 4 1 2 2 2 3 3 2 2| 47 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 1.0|
|__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Iliac, Hyperplasia, Lymphoid | | 1 4.0|
Lumbar, Hyperplasia, Lymphoid | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Hyperplasia, Histiocytic | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 3 1 2 3 2 1 | 30 1.5|
Hyperplasia, Lymphoid | | 1 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 3 4 2 2 2 3 3 2 3 | 19 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| |
DAY ON TEST | 4| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 8| 2| 3| 3| 2| 3| 3| 3| |
| 7| 3| 0| 0| 0| 0| 0| 1| 9| 1| 1| 2| 0| 1| 1| 1| 0| 6| 9| 1| 0| 9| 1| 8| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
300 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Dilatation | | 1 1.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Site of Application - Epidermis, | | |
Hyperplasia | 2 2 2 2 1 2 2 2 1 2 2 3 1 3 2 2 2 3 2 3 2 2| 46 2.0|
Site of Application - Epidermis, | | |
Inflammation, Suppurative | 1 1 1 1 1 2 1 2 1 1 2 | 20 1.5|
Site of Application - Epidermis, | | |
Ulcer | 2 2 | 6 1.5|
Subcutaneous Tissue, Site of | | |
Application - Dermis, | | |
Inflammation, Chronic | 3 1 2 1 1 2 1 2 2 2 1 2 1 2 1 2 | 31 1.6|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 2 1 1 2 | 13 1.5|
Cranium, Callus | | 1 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Hydrocephalus | | 1 1.0|
Artery, Inflammation, Chronic | 2 | 1 2.0|
Hypothalamus, Compression | 3 4 | 3 3.7|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| |
DAY ON TEST | 4| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 8| 2| 3| 3| 2| 3| 3| 3| |
| 7| 3| 0| 0| 0| 0| 0| 1| 9| 1| 1| 2| 0| 1| 1| 1| 0| 6| 9| 1| 0| 9| 1| 8| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
300 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 3 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 1.0|
Mediastinum, Inflammation, Chronic | 3 | 1 3.0|
Serosa, Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 3 1.0|
Metaplasia, Osseous | | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 | 23 1.0|
Pelvis, Inflammation, Granulomatous | 1 | 1 1.0|
Renal Tubule, Cyst | 1| 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 6| 2| 3| 2| 5| 3| 3| 3| 3| 3| 3| 1| 7| 3| 2| 0| 3| 2| 3| 3| 3| 3| 3|
| 0| 7| 7| 7| 1| 9| 3| 0| 1| 0| 0| 1| 0| 7| 0| 0| 9| 4| 0| 6| 1| 0| 0| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Serosa, Inflammation, Granulomatous | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X X X X X X X X X X X X X X|
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X |
Necrosis, Focal | 1 |
Vacuolization Cytoplasmic, Focal | 1 2 1 |
|__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 2 2 3 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 1 1 2 1 2 1 1 3 2 1 2 1 2 1 2 2 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 6| 2| 3| 2| 5| 3| 3| 3| 3| 3| 3| 1| 7| 3| 2| 0| 3| 2| 3| 3| 3| 3| 3|
| 0| 7| 7| 7| 1| 9| 3| 0| 1| 0| 0| 1| 0| 7| 0| 0| 9| 4| 0| 6| 1| 0| 0| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Epithelium, Cyst | 2 |
Epithelium, Hyperplasia, Focal | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Epithelium, Hyperplasia, Focal | |
Serosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 1 |
Valve, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 1 |
Subcapsular, Hyperplasia | 2 2 1 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 2 2 2 2 1 1 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + M + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 1 1 3 2 1 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 6| 2| 3| 2| 5| 3| 3| 3| 3| 3| 3| 1| 7| 3| 2| 0| 3| 2| 3| 3| 3| 3| 3|
| 0| 7| 7| 7| 1| 9| 3| 0| 1| 0| 0| 1| 0| 7| 0| 0| 9| 4| 0| 6| 1| 0| 0| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 3 3 1 2 1 3 2 1 4 3 2|
Mineralization | |
Thrombosis | 4 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Endometrium, Hyperplasia, Cystic | 4 2 3 4 2 3 4 3 2 4 3 2 4 2 3 4 3 2 3 2 3 1 3|
|__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 1 2 1 2 1 3 3 1 3 2 1 3 1 1|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 6| 2| 3| 2| 5| 3| 3| 3| 3| 3| 3| 1| 7| 3| 2| 0| 3| 2| 3| 3| 3| 3| 3|
| 0| 7| 7| 7| 1| 9| 3| 0| 1| 0| 0| 1| 0| 7| 0| 0| 9| 4| 0| 6| 1| 0| 0| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Atrophy | 2 2 3 3 2 4 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Site of Application - Epidermis, | |
Hyperplasia | 2 1 3 2 2 2 2 1 2 1 2 2 2 2 2 3 2 3 3 2 2 3 2 3 2|
Site of Application - Epidermis, | |
Inflammation, Suppurative | 2 3 3 2 3 2 2 3 3 2 3 2 2 2 3 2|
Site of Application - Epidermis, | |
Ulcer | 1 2 2 1 2 2 2 1 2 2 |
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Site of | |
Application - Dermis, | |
Inflammation, Chronic | 2 2 2 1 3 2 1 2 1 1 1 1 3 2 2 3 2 3 2 2 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 1 1 1 2 1 1 1|
Fracture | |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 1 |
Hypothalamus, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 6| 2| 3| 2| 5| 3| 3| 3| 3| 3| 3| 1| 7| 3| 2| 0| 3| 2| 3| 3| 3| 3| 3|
| 0| 7| 7| 7| 1| 9| 3| 0| 1| 0| 0| 1| 0| 7| 0| 0| 9| 4| 0| 6| 1| 0| 0| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sinus, Inflammation, Suppurative | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 1 |
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 1 1 1 1 1 1|
Glomerulus, Cyst | |
Papilla, Necrosis | |
Papilla, Renal Tubule, Atrophy | 1 |
Renal Tubule, Mineralization | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
__________________________________________|__________________________________________________________________________
Page 41
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 1| 8| 3| 1| 3| 3| 0| 3| 8| 3| 0| 0| 3| 2| 9| 3| 2| 3| 3| 3| 3| 1| 3| 3| |
| 9| 0| 5| 0| 9| 1| 1| 1| 0| 5| 1| 1| 9| 0| 6| 5| 0| 9| 0| 1| 1| 1| 2| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | 2 | 1 2.0|
Serosa, Inflammation, Granulomatous | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 3 |
Clear Cell Focus | X | 5 |
Eosinophilic Focus | X X X X X X X X X X X X X X X X X | 32 |
Hematopoietic Cell Proliferation | 3 4 3 1 | 4 2.8|
Infiltration Cellular, Lymphoid | 2 1 1 1 2 1 1 1 1 1 1| 20 1.1|
Inflammation, Chronic | 1 1 1 1 1 1 | 15 1.0|
Mixed Cell Focus | X X X X X X X X | 11 |
Necrosis, Focal | 3 3 | 3 2.3|
Vacuolization Cytoplasmic, Focal | 1 1 1 | 6 1.2|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Fat, Necrosis | 2 2 2 3 2 | 9 2.3|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + + + +| 31 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 1| 8| 3| 1| 3| 3| 0| 3| 8| 3| 0| 0| 3| 2| 9| 3| 2| 3| 3| 3| 3| 1| 3| 3| |
| 9| 0| 5| 0| 9| 1| 1| 1| 0| 5| 1| 1| 9| 0| 6| 5| 0| 9| 0| 1| 1| 1| 2| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation, Chronic | 2 2 1 2 1 1 1 2 1 1 2 2 1| 31 1.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
Epithelium, Cyst | | 1 2.0|
Epithelium, Hyperplasia, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 | 1 2.0|
Epithelium, Hyperplasia, Focal | 3 | 1 3.0|
Serosa, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic | | 1 1.0|
Valve, Inflammation | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy, Focal | | 1 1.0|
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2| 50 1.9|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 2 1 1 2 1| 18 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 1| 8| 3| 1| 3| 3| 0| 3| 8| 3| 0| 0| 3| 2| 9| 3| 2| 3| 3| 3| 3| 1| 3| 3| |
| 9| 0| 5| 0| 9| 1| 1| 1| 0| 5| 1| 1| 9| 0| 6| 5| 0| 9| 0| 1| 1| 1| 2| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M M + + + +| 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 1 1 2 2 2 | 12 1.6|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | | 2 2.0|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 1 1 1 2 3 2 2 2 2 2 2 1| 25 2.0|
Mineralization | 2 | 1 2.0|
Thrombosis | | 1 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.5|
Endometrium, Hyperplasia, Cystic | 3 3 2 3 1 3 2 2 4 2 3 4 2 4 4 4 2 2 3 3 3 2 2 2| 47 2.8|
|__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + | 6 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 1| 8| 3| 1| 3| 3| 0| 3| 8| 3| 0| 0| 3| 2| 9| 3| 2| 3| 3| 3| 3| 1| 3| 3| |
| 9| 0| 5| 0| 9| 1| 1| 1| 0| 5| 1| 1| 9| 0| 6| 5| 0| 9| 0| 1| 1| 1| 2| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Mediastinal, Hyperplasia, Lymphoid | 3 2 | 2 2.5|
Renal, Hyperplasia, Lymphoid | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 1 2 1 1 1 1 1 2 3 2 2 3 1 1 1 1 1 1 | 33 1.6|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Atrophy | 3 3 4 2 4 3 2 2 1 | 16 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Site of Application - Epidermis, | | |
Hyperplasia | 3 2 2 2 1 1 3 2 2 1 2 2 2 3 1 2 2 2 2 2 1 2 1 2 2| 50 2.0|
Site of Application - Epidermis, | | |
Inflammation, Suppurative | 3 1 1 2 1 2 1 2 2 3 2 3 1 3 1 2 | 32 2.2|
Site of Application - Epidermis, | | |
Ulcer | 2 1 2 1 1 2 2 | 17 1.6|
Subcutaneous Tissue, Fibrosis | 3 | 1 3.0|
Subcutaneous Tissue, Site of | | |
Application - Dermis, | | |
Inflammation, Chronic | 2 1 1 1 1 3 1 3 1 2 2 2 2 1 2 1 2 2 1 2 1 2 1| 44 1.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 1| 10 1.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 1| 8| 3| 1| 3| 3| 0| 3| 8| 3| 0| 0| 3| 2| 9| 3| 2| 3| 3| 3| 3| 1| 3| 3| |
| 9| 0| 5| 0| 9| 1| 1| 1| 0| 5| 1| 1| 9| 0| 6| 5| 0| 9| 0| 1| 1| 1| 2| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Fracture | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 1.0|
Hypothalamus, Compression | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sinus, Inflammation, Suppurative | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 3 4 | 5 2.6|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 1 | 3 1.0|
Metaplasia, Osseous | 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 1| 8| 3| 1| 3| 3| 0| 3| 8| 3| 0| 0| 3| 2| 9| 3| 2| 3| 3| 3| 3| 1| 3| 3| |
| 9| 0| 5| 0| 9| 1| 1| 1| 0| 5| 1| 1| 9| 0| 6| 5| 0| 9| 0| 1| 1| 1| 2| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Nephropathy | 1 3 1 1 1 1 1 1 1 1 1 1 | 20 1.1|
Glomerulus, Cyst | 2 | 1 2.0|
Papilla, Necrosis | 2 | 1 2.0|
Papilla, Renal Tubule, Atrophy | | 1 1.0|
Renal Tubule, Mineralization | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Cyst | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7|
DAY ON TEST | 2| 2| 6| 2| 2| 8| 2| 2| 1| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 1| 2| 2|
| 7| 8| 4| 7| 7| 0| 6| 7| 4| 6| 8| 6| 8| 7| 6| 6| 8| 6| 6| 7| 5| 4| 1| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + + + + M + + +|
Necrosis | 4 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Peyer's Patch, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X X X X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 1 1 |
Hepatodiaphragmatic Nodule | |
Infiltration Cellular, Lymphoid | 1 |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 1 1 1|
Mixed Cell Focus | X X X X |
Necrosis, Focal | 1 4 |
Vacuolization Cytoplasmic, Focal | 1 1 |
|__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7|
DAY ON TEST | 2| 2| 6| 2| 2| 8| 2| 2| 1| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 1| 2| 2|
| 7| 8| 4| 7| 7| 0| 6| 7| 4| 6| 8| 6| 8| 7| 6| 6| 8| 6| 6| 7| 5| 4| 1| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Inflammation, Chronic | 1 2 3 2 2 2 2 2 2 2 2 2 2 1 2 2|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Epithelium, Hyperplasia, Focal | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + |
Malformation | 3 2 3 1 1 4 3 2 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 |
Inflammation, Acute | 3 |
Atrium, Thrombosis | 4 |
Myocardium, Mineralization | |
Ventricle, Thrombosis | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 1 2|
Hypertrophy, Focal | 1 3 1 1 2 2 |
Subcapsular, Hyperplasia | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 2 2 3 3 3 3 2 2 2 3 2 2 1 3 2 4 3 2 1 2 3 |
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7|
DAY ON TEST | 2| 2| 6| 2| 2| 8| 2| 2| 1| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 1| 2| 2|
| 7| 8| 4| 7| 7| 0| 6| 7| 4| 6| 8| 6| 8| 7| 6| 6| 8| 6| 6| 7| 5| 4| 1| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + M + + + + M + M M + + + M + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 |
Pars Intermedia, Hyperplasia | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 |
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7|
DAY ON TEST | 2| 2| 6| 2| 2| 8| 2| 2| 1| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 1| 2| 2|
| 7| 8| 4| 7| 7| 0| 6| 7| 4| 6| 8| 6| 8| 7| 6| 6| 8| 6| 6| 7| 5| 4| 1| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 |
Hematopoietic Cell Proliferation | 2 2 1 1 3 |
Lymphoid Follicle, Hematopoietic | |
Cell Proliferation | 1 |
Red Pulp, Infiltration Cellular, | |
Mononuclear Cell | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 4 4 2 4 3 3 4 4 2 1 2 1 4 2 4 1 4 4 4 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M + M M M + M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperkeratosis | 1 |
Epidermis, Ulcer | 3 |
Site of Application - Epidermis, | |
Hyperkeratosis | 1 |
Site of Application - Epidermis, | |
Hyperplasia | 2 1 |
Site of Application - Epidermis, | |
Inflammation, Suppurative | 1 |
Subcutaneous Tissue, Site of | |
Application - Dermis, | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7|
DAY ON TEST | 2| 2| 6| 2| 2| 8| 2| 2| 1| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 1| 2| 2|
| 7| 8| 4| 7| 7| 0| 6| 7| 4| 6| 8| 6| 8| 7| 6| 6| 8| 6| 6| 7| 5| 4| 1| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Granulomatous | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Retrobulbar, Inflammation, | |
Suppurative | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Inflammation, Acute | 2 |
Metaplasia, Osseous | 1 |
Nephropathy | 2 1 1 1 1 2 1 1 2 1 1 2 1 1 1 1 1 1 1 1 2|
Renal Tubule, Cyst | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7|
DAY ON TEST | 2| 2| 6| 2| 2| 8| 2| 2| 1| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 1| 2| 2|
| 7| 8| 4| 7| 7| 0| 6| 7| 4| 6| 8| 6| 8| 7| 6| 6| 8| 6| 6| 7| 5| 4| 1| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Cyst | 4 |
Inflammation, Acute | 2 |
__________________________________________|__________________________________________________________________________
Page 53
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 7| 7| 6| 4| 4| 6| 7| 7| 8| 6| 7| 8| 7| 8| 6| 8| 6| 8| 7| 7| 6| 5| 8| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Necrosis | | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | 1 | 1 1.0|
Peyer's Patch, Hyperplasia, Lymphoid | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Clear Cell Focus | X X X X X X X X X X X X| 19 |
Eosinophilic Focus | X X X X X X X X | 9 |
Hematopoietic Cell Proliferation | 1 | 3 1.0|
Hepatodiaphragmatic Nodule | 1 | 1 1.0|
Infiltration Cellular, Lymphoid | 1 1 | 3 1.0|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic | 1 1 1 1 | 9 1.0|
Mixed Cell Focus | X X X X X X X X X | 13 |
Necrosis, Focal | 1 1 | 4 1.8|
Vacuolization Cytoplasmic, Focal | | 2 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 7| 7| 6| 4| 4| 6| 7| 7| 8| 6| 7| 8| 7| 8| 6| 8| 6| 8| 7| 7| 6| 5| 8| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + | 3 |
Fat, Necrosis | 2 | 3 2.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + + + + + + | 31 |
Inflammation, Chronic | 2 2 3 1 1 1 1 2 2 2 3 3 1 2 1 | 31 1.9|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
Epithelium, Hyperplasia, Focal | 1 2 3 | 3 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + +| 19 |
Malformation | 1 1 4 3 2 1 2 1 2 2| 19 2.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 3 1.0|
Inflammation, Acute | | 1 3.0|
Atrium, Thrombosis | | 1 4.0|
Myocardium, Mineralization | 1 | 1 1.0|
Ventricle, Thrombosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 7| 7| 6| 4| 4| 6| 7| 7| 8| 6| 7| 8| 7| 8| 6| 8| 6| 8| 7| 7| 6| 5| 8| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia, Focal | 2 1 1 2 | 8 1.5|
Hypertrophy, Focal | 2 2 2 2 1 2 2 1 1 1 | 16 1.6|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 3 1 1 1 3 1 1 1 1 3 1| 39 1.2|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 3 2 1 2 2 2 2 1 1 2 2 1 2 1 2 2 2 2 2| 45 2.2|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + M + + + + + + M + + + M + + M + + + +| 38 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | | 1 2.0|
Pars Intermedia, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 1 2 1 3 2 2 | 10 1.9|
Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 7| 7| 6| 4| 4| 6| 7| 7| 8| 6| 7| 8| 7| 8| 6| 8| 6| 8| 7| 7| 6| 5| 8| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 1 1 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Spleen | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 4 | 4 3.5|
Hematopoietic Cell Proliferation | 3 2 1 1 1 1 1 2 1 | 14 1.6|
Lymphoid Follicle, Hematopoietic | | |
Cell Proliferation | | 1 1.0|
Red Pulp, Infiltration Cellular, | | |
Mononuclear Cell | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + M + + + + + + + + + + +| 48 |
Atrophy | 4 4 3 4 2 2 2 2 3 2 4 4 2 4 1 2 1| 38 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M + M M M M M M M M M M M M M M M M M M M| 3 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Hyperkeratosis | | 1 1.0|
Epidermis, Ulcer | | 1 3.0|
Site of Application - Epidermis, | | |
Hyperkeratosis | 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 7| 7| 6| 4| 4| 6| 7| 7| 8| 6| 7| 8| 7| 8| 6| 8| 6| 8| 7| 7| 6| 5| 8| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Site of Application - Epidermis, | | |
Hyperplasia | 1 1 1 | 5 1.2|
Site of Application - Epidermis, | | |
Inflammation, Suppurative | | 1 1.0|
Subcutaneous Tissue, Site of | | |
Application - Dermis, | | |
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | +| 1 |
|__________________________________________________________________________|____________|
Spinal Cord | +| 1 |
Necrosis | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Granulomatous | 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 2 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 7| 7| 6| 4| 4| 6| 7| 7| 8| 6| 7| 8| 7| 8| 6| 8| 6| 8| 7| 7| 6| 5| 8| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 4 | 1 4.0|
Retrobulbar, Inflammation, | | |
Suppurative | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 1 | 2 1.5|
Inflammation, Acute | 3 | 2 2.5|
Metaplasia, Osseous | | 1 1.0|
Nephropathy | 1 2 2 1 2 1 1 1 1 1 1 1 1 2 2 1 2 1| 39 1.3|
Renal Tubule, Cyst | 2 2 2 3 | 4 2.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 4.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 3| 5| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 1| 2|
| 7| 7| 7| 6| 7| 8| 4| 4| 6| 7| 8| 7| 6| 7| 7| 8| 7| 6| 7| 8| 6| 8| 6| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
Serosa, Inflammation, Granulomatous | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X X X X X X X X |
Eosinophilic Focus | X X X X X X X X X X X|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 1 1|
Infiltration Cellular, Lymphoid | 1 |
Inflammation, Chronic | 1 1 1 1 1|
Mixed Cell Focus | X X X X |
Necrosis, Focal | 2 1 |
Vacuolization Cytoplasmic, Focal | |
Centrilobular, Necrosis | 2 |
|__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 3 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 3 2 2 2 3 2 3 1 2 1 1 2 2|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 3| 5| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 1| 2|
| 7| 7| 7| 6| 7| 8| 4| 4| 6| 7| 8| 7| 6| 7| 7| 8| 7| 6| 7| 8| 6| 8| 6| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Ectasia | |
|__________________________________________________________________________|
Tooth | + + + + + + + + |
Malformation | 2 1 1 3 2 3 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 2 |
Artery, Inflammation, Chronic | |
Atrium, Thrombosis | 4 |
Myocardium, Degeneration | 2 |
Valve, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 |
Hypertrophy, Focal | 1 1 1 1 2 2 1 2 2 2 1 1|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 2 2 1 1 |
Zona Glomerulosa, Hyperplasia | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 2 1 1 2 1 2 2 2 3 3 3 2 3 3 2 3 1 2 |
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 3| 5| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 1| 2|
| 7| 7| 7| 6| 7| 8| 4| 4| 6| 7| 8| 7| 6| 7| 7| 8| 7| 6| 7| 8| 6| 8| 6| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + M + + + M + + + + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | 2 2 2 2 2 2 2 2 2 |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 1 |
Germinal Epithelium, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 62
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 3| 5| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 1| 2|
| 7| 7| 7| 6| 7| 8| 4| 4| 6| 7| 8| 7| 6| 7| 7| 8| 7| 6| 7| 8| 6| 8| 6| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 1 3 1 1 2 2 2 1 2 1|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +|
Atrophy | 3 1 1 4 4 4 4 4 2 3 1 2 1 2 4 2 3 3 1 4 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M + M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Site of Application - Epidermis, | |
Hyperplasia | 2 1 1 1 1 1 2 1 3 2 1 2 3 1 2 1 2 1 1|
Site of Application - Epidermis, | |
Inflammation, Suppurative | 1 2 1 2 2 2 |
Site of Application - Epidermis, | |
Ulcer | 1 1 |
Subcutaneous Tissue, Site of | |
Application - Dermis, | |
Inflammation, Chronic | 1 2 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 3| 5| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 1| 2|
| 7| 7| 7| 6| 7| 8| 4| 4| 6| 7| 8| 7| 6| 7| 7| 8| 7| 6| 7| 8| 6| 8| 6| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Bronchus, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp, Inflammatory | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infarct | 1 |
Metaplasia, Osseous | 1 1 |
Nephropathy | 2 1 1 1 1 1 2 1 1 1 1 1 1 2 1 3 1 1 2 1|
Artery, Thrombosis | 2 |
Glomerulus, Cyst | 2 |
Renal Tubule, Cyst | |
Renal Tubule, Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 64
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 0| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 7| 6| 6| 6| 6| 6| 6| 2| 6| 0| 7| 6| 7| 8| 7| 8| 8| 7| 7| 6| 6| 6| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
200 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 2 | 1 2.0|
Serosa, Inflammation, Granulomatous | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X | 6 |
Clear Cell Focus | X X X X X X X X X X X X 2 X| 23 2.0|
Eosinophilic Focus | X X X X X X X X X| 20 |
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | 2 1 | 4 1.3|
Infiltration Cellular, Lymphoid | 2 | 2 1.5|
Inflammation, Chronic | 1 1 1 1 1 1 2 1 1 | 14 1.1|
Mixed Cell Focus | X X X X X X X | 11 |
Necrosis, Focal | 1 | 3 1.3|
Vacuolization Cytoplasmic, Focal | 1 | 1 1.0|
Centrilobular, Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | 3 | 3 2.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 0| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 7| 6| 6| 6| 6| 6| 6| 2| 6| 0| 7| 6| 7| 8| 7| 8| 8| 7| 7| 6| 6| 6| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
200 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + + + | 26 |
Inflammation, Chronic | 1 2 2 1 2 1 3 3 2 2 1 2 | 26 1.9|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Ectasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + +| 18 |
Malformation | 1 1 3 1 3 1 1 1 2 4| 18 1.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 2.0|
Artery, Inflammation, Chronic | 1 | 1 1.0|
Atrium, Thrombosis | | 1 4.0|
Myocardium, Degeneration | | 1 2.0|
Valve, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 1 | 4 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 0| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 7| 6| 6| 6| 6| 6| 6| 2| 6| 0| 7| 6| 7| 8| 7| 8| 8| 7| 7| 6| 6| 6| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
200 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hypertrophy, Focal | 1 1 1 1 1 1 1 2 1| 21 1.3|
Subcapsular, Hyperplasia | 2 1 2 2 1 2 1 2 1 1 1 1 1 1 2 1 1 2 1 1 1 1| 45 1.2|
Zona Glomerulosa, Hyperplasia | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 3 2 3 1 2 2 1 2 1 3 1 2 1 1 1 2 2 2 2 3| 43 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + M + + + + + + + + + + + M +| 43 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 1.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Cyst | 2 3 2 2 2 | 14 2.1|
Inflammation, Suppurative | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 0| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 7| 6| 6| 6| 6| 6| 6| 2| 6| 0| 7| 6| 7| 8| 7| 8| 8| 7| 7| 6| 6| 6| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
200 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Hyperplasia | | 2 1.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 1 | 2 1.0|
Germinal Epithelium, Mineralization | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 2 1 3 1| 20 1.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + M + + + + + + + + +| 47 |
Atrophy | 1 1 2 2 4 2 2 1 3 1 1 2 2 2 1 2| 37 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M + M M M M M M M M M M + M M M M M M M M M| 3 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Site of Application - Epidermis, | | |
Hyperplasia | 1 1 2 1 2 1 1 1 2 2 2 2 2 1 1 1 1 2 2 1 1 1 2 2 1| 44 1.5|
Site of Application - Epidermis, | | |
Inflammation, Suppurative | 1 2 1 1 1 | 11 1.5|
Site of Application - Epidermis, | | |
Ulcer | 1 | 3 1.0|
Subcutaneous Tissue, Site of | | |
Application - Dermis, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 0| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 7| 6| 6| 6| 6| 6| 6| 2| 6| 0| 7| 6| 7| 8| 7| 8| 8| 7| 7| 6| 6| 6| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
200 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 | 15 1.1|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 2 1.5|
Bronchus, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Polyp, Inflammatory | 3| 1 3.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 5 1.6|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 0| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 7| 6| 6| 6| 6| 6| 6| 2| 6| 0| 7| 6| 7| 8| 7| 8| 8| 7| 7| 6| 6| 6| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
200 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Infarct | 1 1 | 3 1.0|
Metaplasia, Osseous | 1 1 | 4 1.0|
Nephropathy | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 42 1.2|
Artery, Thrombosis | | 1 2.0|
Glomerulus, Cyst | 3 | 2 2.5|
Renal Tubule, Cyst | 2 1 | 2 1.5|
Renal Tubule, Hyperplasia | 1| 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 4| 4| 6| 5| 7| 7| 7| 4| 6|
DAY ON TEST | 2| 2| 2| 8| 2| 2| 2| 2| 2| 0| 2| 1| 2| 2| 5| 2| 8| 4| 9| 6| 2| 2| 2| 3| 1|
| 7| 7| 6| 7| 6| 7| 6| 6| 8| 3| 8| 7| 8| 7| 9| 7| 6| 3| 1| 6| 6| 8| 6| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
630 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Goblet Cell, Hyperplasia | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Infiltration Cellular, | |
Mononuclear Cell | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X X X X X X X X X X X X X X X X|
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | |
Infiltration Cellular, Lymphoid | |
Inflammation, Chronic | 1 1 1 |
Mixed Cell Focus | X X X X X|
Necrosis, Focal | 1 1 2|
Vacuolization Cytoplasmic, Focal | 1 1 1 |
Centrilobular, Necrosis | |
|__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Granulomatous | 1 |
Fat, Necrosis | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 4| 4| 6| 5| 7| 7| 7| 4| 6|
DAY ON TEST | 2| 2| 2| 8| 2| 2| 2| 2| 2| 0| 2| 1| 2| 2| 5| 2| 8| 4| 9| 6| 2| 2| 2| 3| 1|
| 7| 7| 6| 7| 6| 7| 6| 6| 8| 3| 8| 7| 8| 7| 9| 7| 6| 3| 1| 6| 6| 8| 6| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
630 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 2 2 2 2 1 2 2 2 1 2 1 2 2 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Epithelium, Hyperplasia, Focal | 2 1 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
|__________________________________________________________________________|
Tooth | + + + + + |
Malformation | 2 1 2 3 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1|
Hypertrophy, Focal | 1 2 2 |
Necrosis | 3 |
Subcapsular, Hyperplasia | 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 3 2 1 1|
Zona Glomerulosa, Hyperplasia | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 4| 4| 6| 5| 7| 7| 7| 4| 6|
DAY ON TEST | 2| 2| 2| 8| 2| 2| 2| 2| 2| 0| 2| 1| 2| 2| 5| 2| 8| 4| 9| 6| 2| 2| 2| 3| 1|
| 7| 7| 6| 7| 6| 7| 6| 6| 8| 3| 8| 7| 8| 7| 9| 7| 6| 3| 1| 6| 6| 8| 6| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
630 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hyperplasia | 2 1 3 2 3 2 3 1 3 3 2 1 1 2 1 1 2 2 2 2 1 2|
|__________________________________________________________________________|
Parathyroid Gland | + + M + + M M + + + M + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
Cyst | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 3 2 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 1 |
Germinal Epithelium, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 4| 4| 6| 5| 7| 7| 7| 4| 6|
DAY ON TEST | 2| 2| 2| 8| 2| 2| 2| 2| 2| 0| 2| 1| 2| 2| 5| 2| 8| 4| 9| 6| 2| 2| 2| 3| 1|
| 7| 7| 6| 7| 6| 7| 6| 6| 8| 3| 8| 7| 8| 7| 9| 7| 6| 3| 1| 6| 6| 8| 6| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
630 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 3 2 1 2 2 1 1 1 1|
Lymphoid Follicle, Hematopoietic | |
Cell Proliferation | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 3 4 4 4 1 2 3 2 3 3 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Edema | 3 |
Site of Application - Epidermis, | |
Hyperplasia | 3 2 1 3 2 1 2 2 2 3 2 2 1 1 2 2 2 2 1 1 2|
Site of Application - Epidermis, | |
Inflammation, Suppurative | 1 1 2 2 2 2 3 1 1 1 1 1 2 1 |
Site of Application - Epidermis, | |
Ulcer | 1 2 1 2 3 1 1 1 1 |
Subcutaneous Tissue, Site of | |
Application - Dermis, | |
Inflammation, Chronic | 2 2 1 2 1 1 2 1 2 1 2 1 1 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 74
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 4| 4| 6| 5| 7| 7| 7| 4| 6|
DAY ON TEST | 2| 2| 2| 8| 2| 2| 2| 2| 2| 0| 2| 1| 2| 2| 5| 2| 8| 4| 9| 6| 2| 2| 2| 3| 1|
| 7| 7| 6| 7| 6| 7| 6| 6| 8| 3| 8| 7| 8| 7| 9| 7| 6| 3| 1| 6| 6| 8| 6| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
630 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 1 2 3 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 |
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Capsule, Inflammation, Chronic | 2 |
Papilla, Necrosis | 3 |
Renal Tubule, Hyperplasia | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 75
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 7| 2| 9| 2| 2| 2| 7| 2| 2| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| |
| 8| 6| 8| 8| 6| 8| 3| 6| 9| 7| 6| 7| 6| 7| 8| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
630 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
Goblet Cell, Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Muscularis, Infiltration Cellular, | | |
Mononuclear Cell | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 3 |
Clear Cell Focus | X X X X X X X X X X| 14 |
Eosinophilic Focus | X X X X X X X X X X X 2 X X | 31 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X | 1 |
Infiltration Cellular, Lymphoid | 1 2 | 2 1.5|
Inflammation, Chronic | 1 1 1 1 1 1 1 | 10 1.0|
Mixed Cell Focus | X X X X X X X X X X | 15 |
Necrosis, Focal | 3 3 2 2 | 7 2.0|
Vacuolization Cytoplasmic, Focal | | 3 1.0|
Centrilobular, Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 7| 2| 9| 2| 2| 2| 7| 2| 2| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| |
| 8| 6| 8| 8| 6| 8| 3| 6| 9| 7| 6| 7| 6| 7| 8| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
630 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Inflammation, Granulomatous | | 1 1.0|
Fat, Necrosis | 2 3 | 4 2.3|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + + | 35 |
Inflammation, Chronic | 1 2 2 3 2 1 2 3 1 2 2 2 2 2 1 2 1 2 2 | 35 1.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 | 1 2.0|
Epithelium, Hyperplasia, Focal | | 3 1.7|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + +| 14 |
Malformation | 1 3 4 1 1 3 1 3 2| 14 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 | 3 1.0|
Hypertrophy, Focal | 1 1 1 1 1 1 1 | 10 1.2|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 7| 2| 9| 2| 2| 2| 7| 2| 2| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| |
| 8| 6| 8| 8| 6| 8| 3| 6| 9| 7| 6| 7| 6| 7| 8| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
630 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Necrosis | | 1 3.0|
Subcapsular, Hyperplasia | 1 1 1 3 1 1 1 2 2 3 3 2 3 3 1 1 1 1 1 1 3| 40 1.5|
Zona Glomerulosa, Hyperplasia | 2 2| 3 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 3 2 3 2 2 2 1 1 2 2 3 3 1 2 1 2 2 1 2 2| 43 1.9|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + M + + + M M + + + M + + + + + + + + +| 39 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
Cyst | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 2 2 2 2 | 11 2.1|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 7| 2| 9| 2| 2| 2| 7| 2| 2| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| |
| 8| 6| 8| 8| 6| 8| 3| 6| 9| 7| 6| 7| 6| 7| 8| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
630 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | | 1 1.0|
Germinal Epithelium, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + M + + + + + + + + + + + + + + +| 48 |
Congestion | | 1 3.0|
Hyperplasia, Lymphoid | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 1 2 2 1 | 17 1.7|
Lymphoid Follicle, Hematopoietic | | |
Cell Proliferation | 2| 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + M + + + + + + + + + +| 48 |
Atrophy | 1 2 4 2 1 3 4 2 3 1 1 4 2 2 1 2 2 1 2 4| 37 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dermis, Edema | | 1 3.0|
Site of Application - Epidermis, | | |
Hyperplasia | 2 2 2 2 2 3 2 2 3 2 2 1 3 2 2 3 2 2 1 2 2 2 2 2| 45 2.0|
Site of Application - Epidermis, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 7| 2| 9| 2| 2| 2| 7| 2| 2| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| |
| 8| 6| 8| 8| 6| 8| 3| 6| 9| 7| 6| 7| 6| 7| 8| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
630 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Inflammation, Suppurative | 1 1 1 1 2 2 2 2 1 2 2 3 2 2 3 2 1 1 3| 33 1.7|
Site of Application - Epidermis, | | |
Ulcer | 1 1 2 1 2 1 1 2 2 1 1| 20 1.4|
Subcutaneous Tissue, Site of | | |
Application - Dermis, | | |
Inflammation, Chronic | 2 2 2 1 1 2 1 2 2 2 2 2 1 1 2 2 2 1 2 1 2 2| 40 1.6|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 6 1.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 7| 2| 9| 2| 2| 2| 7| 2| 2| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| |
| 8| 6| 8| 8| 6| 8| 3| 6| 9| 7| 6| 7| 6| 7| 8| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
630 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 1 | 2 1.0|
Metaplasia, Osseous | 1 | 2 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 37 1.0|
Capsule, Inflammation, Chronic | | 1 2.0|
Papilla, Necrosis | | 1 3.0|
Renal Tubule, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 2| 9| 2| 2| 7| 8| 2| 2| 2|
| 7| 4| 6| 8| 6| 6| 6| 8| 7| 7| 4| 7| 6| 6| 6| 8| 8| 9| 7| 7| 2| 4| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + M + + + M + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X X X |
Eosinophilic Focus | X X X X X X X X X X X X X X|
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Lymphoid | |
Inflammation, Chronic | 1 1 1 1 1 1 1 |
Mixed Cell Focus | X X X X X |
Necrosis, Focal | 1 2 1 2 1 |
Vacuolization Cytoplasmic, Focal | 1 1 |
|__________________________________________________________________________|
Mesentery | + + + + + |
Artery, Inflammation, Chronic | 3 |
Fat, Necrosis | 2 1 2 2 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + +|
Inflammation, Chronic | 3 2 2 3 3 2 2 1 3 2 3 2 1|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 3 |
__________________________________________|__________________________________________________________________________|
Page 82
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 2| 9| 2| 2| 7| 8| 2| 2| 2|
| 7| 4| 6| 8| 6| 6| 6| 8| 7| 7| 4| 7| 6| 6| 6| 8| 8| 9| 7| 7| 2| 4| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Epithelium, Cyst | |
Epithelium, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Epithelium, Hyperplasia, Focal | |
|__________________________________________________________________________|
Tongue | |
|__________________________________________________________________________|
Tooth | + + + + + + +|
Malformation | 2 1 1 1 3 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation, Chronic | 1 |
Pulmonary Vein, Thrombosis | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Artery, Inflammation, Chronic | 1 3|
Coronary Artery, Inflammation, | |
Chronic | 2 |
Myocardium, Mineralization | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 2 1 2 1 |
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 2 2 1 1 2 1 1 1 1 1 1 2 1|
Zona Glomerulosa, Hyperplasia | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 2| 9| 2| 2| 7| 8| 2| 2| 2|
| 7| 4| 6| 8| 6| 6| 6| 8| 7| 7| 4| 7| 6| 6| 6| 8| 8| 9| 7| 7| 2| 4| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 1 2 1 1 2 3 1 2 1 2 3 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | |
Pars Intermedia, Hyperplasia | 3 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 2 2 2 2 3 2 3|
Inflammation, Chronic | 2 1 |
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Germinal Epithelium, Atrophy | |
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 2| 9| 2| 2| 7| 8| 2| 2| 2|
| 7| 4| 6| 8| 6| 6| 6| 8| 7| 7| 4| 7| 6| 6| 6| 8| 8| 9| 7| 7| 2| 4| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 2 2 1 2 1 1|
|__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + M + + + + + +|
Atrophy | 2 2 4 3 4 2 3 2 4 1 4 3 2 3 4 2 3 1 1 4 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Site of Application - Epidermis, | |
Hyperplasia | 3 1 3 3 1 4 3 3 3 3 1 3 3 3 3 3 1 1 4 3 2 2 3 4 3|
Site of Application - Epidermis, | |
Inflammation, Suppurative | 3 3 3 3 4 3 1 3 2 1 3 2 4 3 4 3 2 2 3 |
Site of Application - Epidermis, | |
Ulcer | 3 1 3 3 3 1 4 3 4 3 2 3 2 1 1 2 4 3 4 2 2 2 2 3 4|
Subcutaneous Tissue, Site of | |
Application - Dermis, | |
Inflammation, Chronic | 2 1 3 2 2 3 3 3 3 3 1 3 3 3 3 3 3 1 3 2 3 1 3 3 X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 2| 9| 2| 2| 7| 8| 2| 2| 2|
| 7| 4| 6| 8| 6| 6| 6| 8| 7| 7| 4| 7| 6| 6| 6| 8| 8| 9| 7| 7| 2| 4| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Perivascular, Infiltration Cellular, | |
Lymphoid | |
Vein, Thrombosis | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Respiratory Epithelium, | |
Mineralization | 1|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cornea, Inflammation, Acute | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 2|
Metaplasia, Osseous | |
Nephropathy | 1 1 1 1 2 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 2|
Glomerulus, Cyst | |
Renal Tubule, Cyst | 2 1 1 |
Renal Tubule, Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 86
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| |
| 8| 8| 6| 6| 6| 6| 7| 6| 7| 4| 3| 7| 6| 8| 8| 6| 8| 6| 7| 7| 8| 7| 7| 6| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Clear Cell Focus | X X X X X| 11 |
Eosinophilic Focus | X X X X X X X X X X X X X X X X | 30 |
Hematopoietic Cell Proliferation | 2 1 | 2 1.5|
Infiltration Cellular, Lymphoid | 1 1 1 | 3 1.0|
Inflammation, Chronic | 1 1 1 1 | 11 1.0|
Mixed Cell Focus | X X X | 8 |
Necrosis, Focal | 1 | 6 1.3|
Vacuolization Cytoplasmic, Focal | 1 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Artery, Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | 2 | 5 1.8|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + + + + + + + +| 30 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| |
| 8| 8| 6| 6| 6| 6| 7| 6| 7| 4| 3| 7| 6| 8| 8| 6| 8| 6| 7| 7| 8| 7| 7| 6| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation, Chronic | 1 1 1 1 2 3 1 2 1 1 2 1 1 2 1 1 1| 30 1.7|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
Epithelium, Cyst | 2 | 1 2.0|
Epithelium, Hyperplasia, Focal | 1 | 2 1.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
|__________________________________________________________________________|____________|
Tooth | + + + + + +| 13 |
Malformation | 1 1 2 1 1 1| 13 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Inflammation, Chronic | | 1 1.0|
Pulmonary Vein, Thrombosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 2 | 2 1.5|
Artery, Inflammation, Chronic | 2 | 3 2.0|
Coronary Artery, Inflammation, | | |
Chronic | | 1 2.0|
Myocardium, Mineralization | | 2 1.0|
_____________________________________________________________________________________________________________________| |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| |
| 8| 8| 6| 6| 6| 6| 7| 6| 7| 4| 3| 7| 6| 8| 8| 6| 8| 6| 7| 7| 8| 7| 7| 6| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 | 1 1.0|
Hypertrophy, Focal | 1 1 1 1 1 | 10 1.3|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 2 1 2 2 3 3 1 1| 40 1.3|
Zona Glomerulosa, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 1 2 1 1 2 2 2 2 1 1 1 1 2 1 1| 32 1.6|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 3 | 1 3.0|
Pars Intermedia, Hyperplasia | 2 | 3 2.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2| 2 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 2 2 2| 15 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| |
| 8| 8| 6| 6| 6| 6| 7| 6| 7| 4| 3| 7| 6| 8| 8| 6| 8| 6| 7| 7| 8| 7| 7| 6| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation, Chronic | | 2 1.5|
Inflammation, Suppurative | 3 3 | 3 2.7|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | 2 | 1 2.0|
Germinal Epithelium, Atrophy | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Hematopoietic Cell Proliferation | 1 2 2 2 1 2 3 1| 19 1.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 2 2 2 2 1 2 3 2 2 2 4 1 2 1 2 2 1| 38 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M + M M M M M M M M M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| |
| 8| 8| 6| 6| 6| 6| 7| 6| 7| 4| 3| 7| 6| 8| 8| 6| 8| 6| 7| 7| 8| 7| 7| 6| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Site of Application - Epidermis, | | |
Hyperplasia | 3 3 3 2 3 3 2 2 3 2 2 3 3 4 3 3 4 3 3 2 3 3 3 3| 49 2.7|
Site of Application - Epidermis, | | |
Inflammation, Suppurative | 4 3 2 3 3 3 2 3 2 4 2 2 3 3 2 4 2 3 3 2 3 3 3| 42 2.8|
Site of Application - Epidermis, | | |
Ulcer | 3 3 2 3 3 3 2 2 4 2 1 3 2 2 2 1 3 3 2 4 2 3| 47 2.6|
Subcutaneous Tissue, Site of | | |
Application - Dermis, | | |
Inflammation, Chronic | 2 3 2 1 3 2 2 2 2 1 3 3 3 3 3 2 3 3 3 3 3 3 3 3| 49 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 1 | 2 1.5|
Perivascular, Infiltration Cellular, | | |
Lymphoid | 3 | 1 3.0|
Vein, Thrombosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Respiratory Epithelium, | | |
Mineralization | | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05109-14 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 06/06/02
Route: SKIN APPLICATION Time: 08:39:51
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| |
| 8| 8| 6| 6| 6| 6| 7| 6| 7| 4| 3| 7| 6| 8| 8| 6| 8| 6| 7| 7| 8| 7| 7| 6| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
MICE:B6C3F1 MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cornea, Inflammation, Acute | | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 3 1 1 | 7 1.4|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 1 | 4 1.5|
Metaplasia, Osseous | 1 1 | 2 1.0|
Nephropathy | 1 1 2 2 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1| 40 1.2|
Glomerulus, Cyst | 2 2 | 2 2.0|
Renal Tubule, Cyst | 1| 4 1.3|
Renal Tubule, Hyperplasia | 1 2 | 2 1.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------