TDMS Study 05109-14 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TRIETHANOLAMINE DATE: 06/06/02
EXPERIMENT: 05109 TEST: 14 TIME: 08:43:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85427 ROUTE: SKIN APPLICATION NTP C#: 61621E
PATHOLOGIST: MISSING CAS: 102-71-6
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1/MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TRIETHANOLAMINE DATE: 06/06/02
EXPERIMENT: 05109 TEST: 14 TIME: 08:43:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85427 ROUTE: SKIN APPLICATION NTP C#: 61621E
PATHOLOGIST: MISSING CAS: 102-71-6
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 726 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 511 580 624 628 664 684 684 688 694 714 |
| 716 725 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 334 502 554 615 637 676 710 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 630 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 439 443 486 487 503 517 566 603 614 659 |
| 673 676 691 699 705 708 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 726 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2000 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 399 554 566 572 618 628 644 683 684 684 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 726 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 726 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 96.0 90.0 74.0 |
| | |
| | |
|200 | 100.0 100.0 100.0 98.0 98.0 98.0 96.0 94.0 90.0 86.0 |
|MG/KG | |
| | |
|630 | 100.0 100.0 100.0 100.0 100.0 96.0 88.0 84.0 80.0 68.0 |
|MG/KG | |
| | |
|2000 | 100.0 100.0 100.0 100.0 98.0 98.0 98.0 92.0 86.0 80.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 200 630 2000 |
| MG/KG MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.0% 86.0% 68.0% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000N P=0.254N P=0.492 P=0.743N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 664.4 575.4 591.8 603.2 |
|NATURAL DEATHS (C) | (17.6) (48.2) (24.9) (27.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 710.0 704.9 683.1 701.4 |
|(STANDARD ERROR) | ( 5.9) ( 9.8) (11.9) ( 8.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 329 469 532 595 617 617 619 619 640 652 |
| 653 657 666 711 717 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 221 239 444 510 594 601 610 665 665 665 |
| 674 674 674 686 698 708 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 62 338 444 447 573 581 586 674 692 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1000 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 1 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 70 527 567 595 604 617 619 653 685 685 |
| 701 701 709 712 717 726 726 |
| CENSORED DEATHS |
| 410 |
| |
==================================================================================
TRIETHANOLAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 98.0 98.0 96.0 94.0 92.0 76.0 70.0 |
| | |
| | |
|100 | 100.0 100.0 96.0 96.0 96.0 94.0 92.0 88.0 80.0 68.0 |
|MG/KG | |
| | |
|300 | 98.0 98.0 98.0 96.0 96.0 92.0 92.0 86.0 86.0 82.0 |
|MG/KG | |
| | |
|1000 | 98.0 98.0 98.0 98.0 98.0 98.0 96.0 89.8 83.7 65.3 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 100 300 1000 |
| MG/KG MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 70.0% 68.0% 82.0% 65.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.759 P=1.000 P=0.293N P=0.865 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 606.2 583.0 488.6 624.4 |
|NATURAL DEATHS (C) | (25.5) (38.7) (65.5) (37.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 692.2 682.3 685.7 687.0 |
|(STANDARD ERROR) | (11.0) (15.5) (17.3) (15.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRIETHANOLAMINE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
200 MG/KG = 2
630 MG/KG = 3
2000 MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 4 3 1
|
| 2 4 33 21 4 1
|
96 + 3 3 2 24 1 1
|
| 244 2
|
P 92 + 3 3 4 2412 1
E |
R | 3 3 442 1 21
C |
E 88 + 3 3 4 4 2 2
N |
T | 3 3 4 11 2 2
|
S 84 + 33 11
U |
R | 3 3 1 1
V |
I 80 + 3 34 114
V |
A | 11
L |
76 + 3 3
|
| 33 1
|
72 + 33
|
| 33
|
68 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
TRIETHANOLAMINE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
100 MG/KG = 2
300 MG/KG = 3
1000 MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 34 2 1
|
| 34 2 2 1 3 1 4
| 2 3 2 1 1 4
95 +
| 2 2 1 4 1
P | 3 2 3 1 4 1
E |
R 90 + 33 224 4
C |
E | 33 2 2
N | 3 24 4 2 3
T 85 +
| 1 1 4 343
S | 1 1 3 3
U |
R 80 + 2 24 4
V |
I |
V | 1 1
A 75 + 44
L | 122 1
| 2 2 11
| 44
70 + 2 214 1
|
| 2 2
|
65 + 4 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.