TDMS Study 05110-02 Pathology Tables
NTP Experiment-Test: 05110-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 02/18/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:59:46
Facility: Battelle Northwest
Chemical CAS #: 91-20-3
Lock Date: 01/05/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05110-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 02/18/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:59:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 10 PPM 30 PPM 60 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 49 49 49 49
Early Deaths
Moribund Sacrifice 18 22 16 21
Natural Death 3 6 5 4
Survivors
Terminal Sacrifice 28 21 28 24
Animals Examined Microscopically 49 49 49 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (48) (48) (48)
Inflammation, Acute 1 (2%)
Liver (49) (49) (49) (49)
Angiectasis 2 (4%) 4 (8%) 2 (4%) 1 (2%)
Basophilic Focus 46 (94%) 44 (90%) 46 (94%) 44 (90%)
Clear Cell Focus 7 (14%) 16 (33%) 8 (16%) 6 (12%)
Cyst 1 (2%)
Eosinophilic Focus 1 (2%) 6 (12%) 2 (4%)
Fatty Change 10 (20%) 3 (6%) 2 (4%) 4 (8%)
Hepatodiaphragmatic Nodule 4 (8%) 1 (2%) 6 (12%) 5 (10%)
Inflammation, Chronic 2 (4%)
Mixed Cell Focus 6 (12%) 6 (12%) 7 (14%) 6 (12%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
Regeneration 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Vacuolization Cytoplasmic, Focal 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 5 (10%) 5 (10%) 5 (10%) 6 (12%)
Centrilobular, Necrosis 11 (22%) 11 (22%) 7 (14%) 9 (18%)
Hepatocyte, Atrophy 1 (2%)
Mesentery (13) (8) (7) (5)
Fat, Hemorrhage 1 (8%)
Fat, Inflammation 1 (13%)
Fat, Necrosis 13 (100%) 7 (88%) 6 (86%) 5 (100%)
Pancreas (49) (49) (49) (49)
Atrophy 18 (37%) 9 (18%) 11 (22%) 10 (20%)
Basophilic Focus 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Duct, Cyst 1 (2%)
Salivary Glands (49) (49) (49) (49)
Atrophy 1 (2%) 2 (4%)
Basophilic Focus 1 (2%)
Stomach, Forestomach (49) (49) (49) (49)
Hyperplasia, Squamous 1 (2%)
Inflammation, Acute 1 (2%)
Ulcer 3 (6%) 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05110-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 02/18/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:59:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 10 PPM 30 PPM 60 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Glandular (49) (48) (49) (49)
Hyperplasia 1 (2%)
Mineralization 2 (4%) 2 (4%) 2 (4%)
Necrosis 3 (6%) 2 (4%) 1 (2%)
Ulcer 1 (2%) 1 (2%)
Tongue (1) (1) (1)
Epithelium, Hyperplasia 1 (100%)
Tooth (1) (1)
Malformation 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (49) (49) (49)
Cardiomyopathy 32 (65%) 31 (63%) 31 (63%) 34 (69%)
Atrium, Thrombosis 2 (4%) 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (49) (49) (49)
Atrophy 2 (4%)
Degeneration, Cystic 4 (8%) 4 (8%) 3 (6%) 3 (6%)
Hyperplasia 23 (47%) 12 (24%) 18 (37%) 24 (49%)
Hypertrophy 7 (14%) 4 (8%) 12 (24%) 6 (12%)
Necrosis 4 (8%) 2 (4%) 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 2 (4%) 1 (2%)
Adrenal Medulla (48) (49) (49) (49)
Hyperplasia 10 (21%) 3 (6%) 9 (18%) 5 (10%)
Necrosis 2 (4%) 1 (2%)
Thrombosis 1 (2%)
Islets, Pancreatic (49) (49) (49) (49)
Hyperplasia 1 (2%)
Parathyroid Gland (42) (40) (41) (48)
Hyperplasia 1 (2%)
Pituitary Gland (49) (49) (49) (48)
Angiectasis 2 (4%) 2 (4%) 3 (6%) 2 (4%)
Cyst 1 (2%)
Pars Distalis, Hyperplasia 24 (49%) 13 (27%) 18 (37%) 15 (31%)
Thyroid Gland (47) (46) (48) (48)
C-Cell, Hyperplasia 39 (83%) 37 (80%) 37 (77%) 42 (88%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05110-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 02/18/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:59:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 10 PPM 30 PPM 60 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (47) (49) (48)
Hyperplasia 1 (2%) 2 (4%) 2 (4%) 3 (6%)
Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%)
Ovary (49) (49) (49) (49)
Cyst 7 (14%) 9 (18%) 11 (22%) 8 (16%)
Inflammation, Granulomatous 1 (2%) 1 (2%) 2 (4%)
Uterus (49) (49) (49) (49)
Cyst 1 (2%)
Vagina (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (49) (49)
Atrophy 1 (2%)
Hyperplasia, Reticulum Cell 1 (2%) 1 (2%)
Myelofibrosis 1 (2%)
Lymph Node, Mediastinal (40) (39) (41) (31)
Congestion 1 (2%)
Hemorrhage 1 (2%)
Spleen (49) (49) (49) (49)
Fibrosis 3 (6%) 3 (6%) 3 (6%) 2 (4%)
Hematopoietic Cell Proliferation 2 (4%) 4 (8%) 1 (2%) 4 (8%)
Hemorrhage 2 (4%) 1 (2%)
Metaplasia, Osseous 1 (2%)
Necrosis 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Thymus (46) (45) (48) (41)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (49) (49) (49)
Galactocele 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Hyperplasia, Atypical 1 (2%)
Inflammation, Chronic Active 2 (4%)
Skin (49) (49) (49) (49)
Hyperkeratosis 1 (2%)
Inflammation, Acute 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05110-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 02/18/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:59:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 10 PPM 30 PPM 60 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Chronic Active 1 (2%)
Epidermis, Hyperplasia 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (49) (49) (49)
Osteopetrosis 10 (20%) 4 (8%) 7 (14%) 5 (10%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (49) (49) (49)
Angiectasis 1 (2%)
Degeneration 1 (2%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (49) (49) (49)
Hyperplasia 1 (2%)
Metaplasia, Squamous 2 (4%) 4 (8%) 1 (2%)
Lung (49) (49) (49) (49)
Congestion, Chronic 1 (2%)
Inflammation, Chronic Active 16 (33%) 15 (31%) 19 (39%) 22 (45%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 11 (22%) 11 (22%) 9 (18%)
Alveolus, Infiltration Cellular, Histiocyte 19 (39%) 7 (14%) 11 (22%) 14 (29%)
Bronchiole, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Nose (49) (49) (49) (49)
Inflammation, Suppurative 2 (4%) 5 (10%) 5 (10%) 5 (10%)
Thrombosis 7 (14%) 4 (8%) 3 (6%) 3 (6%)
Glands, Hyperplasia 48 (98%) 48 (98%) 42 (86%)
Glands, Metaplasia, Squamous 2 (4%) 20 (41%) 20 (41%)
Goblet Cell, Respiratory Epithelium,
Hyperplasia 16 (33%) 29 (59%) 20 (41%)
Olfactory Epithelium, Atrophy 49 (100%) 49 (100%) 47 (96%)
Olfactory Epithelium, Degeneration, Hyaline 13 (27%) 46 (94%) 49 (100%) 45 (92%)
Olfactory Epithelium, Hyperplasia, Atypical 48 (98%) 48 (98%) 43 (88%)
Olfactory Epithelium, Inflammation, Chronic 47 (96%) 47 (96%) 45 (92%)
Respiratory Epithelium, Degeneration, Hyaline 8 (16%) 33 (67%) 34 (69%) 28 (57%)
Respiratory Epithelium, Hyperplasia 18 (37%) 22 (45%) 23 (47%)
Respiratory Epithelium, Metaplasia, Squamous 21 (43%) 17 (35%) 15 (31%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05110-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 02/18/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:59:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 10 PPM 30 PPM 60 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (48) (47) (46) (48)
Cataract 5 (10%) 2 (4%) 6 (13%) 3 (6%)
Cornea, Infiltration Cellular,
Polymorphonuclear 2 (4%)
Retina, Atrophy 5 (10%) 2 (4%) 4 (9%) 2 (4%)
Harderian Gland (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (48) (49) (49) (49)
Cyst 1 (2%)
Infarct 1 (2%) 1 (2%)
Nephropathy 41 (85%) 38 (78%) 34 (69%) 31 (63%)
Renal Tubule, Necrosis 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05110-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 02/18/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:59:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 PPM 30 PPM 60 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 49 49 49 49
Early Deaths
Moribund Sacrifice 21 22 19 25
Natural Death 4 5 6 3
Survivors
Terminal Sacrifice 24 22 23 21
Other 1
Animals Examined Microscopically 49 49 48 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (49) (49) (48) (49)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Basophilic Focus 34 (69%) 31 (63%) 28 (58%) 32 (65%)
Clear Cell Focus 14 (29%) 14 (29%) 14 (29%) 11 (22%)
Degeneration, Cystic 3 (6%) 3 (6%) 2 (4%) 2 (4%)
Eosinophilic Focus 3 (6%) 2 (4%) 1 (2%) 2 (4%)
Fatty Change 2 (4%) 2 (4%) 4 (8%) 5 (10%)
Hepatodiaphragmatic Nodule 1 (2%) 3 (6%) 2 (4%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Mixed Cell Focus 3 (6%) 2 (4%) 2 (4%) 2 (4%)
Necrosis 1 (2%)
Regeneration 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Syncytial Alteration 1 (2%)
Tension Lipidosis 1 (2%)
Artery, Inflammation 1 (2%)
Bile Duct, Hyperplasia 35 (71%) 32 (65%) 28 (58%) 21 (43%)
Centrilobular, Necrosis 13 (27%) 11 (22%) 7 (15%) 4 (8%)
Mesentery (13) (6) (9) (8)
Artery, Inflammation, Chronic Active 3 (23%) 1 (13%)
Artery, Mineralization 1 (11%)
Fat, Hemorrhage 1 (17%)
Fat, Inflammation 1 (17%)
Fat, Necrosis 10 (77%) 4 (67%) 8 (89%) 6 (75%)
Pancreas (49) (49) (48) (49)
Atrophy 19 (39%) 17 (35%) 17 (35%) 14 (29%)
Basophilic Focus 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 3 (6%) 2 (4%) 1 (2%)
Artery, Inflammation 1 (2%) 1 (2%)
Duct, Cyst 1 (2%)
Salivary Glands (49) (49) (47) (49)
Atrophy 1 (2%)
Metaplasia, Squamous 1 (2%)
Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05110-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 02/18/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:59:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 PPM 30 PPM 60 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (49) (49) (48) (49)
Diverticulum 1 (2%)
Hyperplasia, Squamous 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Inflammation, Acute 1 (2%)
Necrosis 1 (2%)
Ulcer 1 (2%) 6 (12%) 3 (6%) 2 (4%)
Stomach, Glandular (49) (49) (48) (49)
Inflammation, Acute 1 (2%)
Mineralization 2 (4%) 1 (2%)
Necrosis 7 (14%) 2 (4%) 2 (4%) 3 (6%)
Ulcer 1 (2%) 1 (2%)
Artery, Inflammation 1 (2%)
Tongue (1) (1)
Epithelium, Hyperplasia 1 (100%)
Tooth (1) (2) (4) (2)
Inflammation, Chronic Active 1 (100%) 1 (50%) 4 (100%)
Malformation 1 (50%) 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (49) (48) (49)
Cardiomyopathy 42 (86%) 44 (90%) 37 (77%) 42 (86%)
Necrosis 1 (2%)
Atrium, Thrombosis 5 (10%) 2 (4%) 3 (6%) 2 (4%)
Valve, Thrombosis, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (49) (48) (49)
Angiectasis 1 (2%) 1 (2%)
Degeneration, Cystic 2 (4%) 1 (2%) 1 (2%)
Hyperplasia 30 (61%) 28 (57%) 23 (48%) 36 (73%)
Hypertrophy 7 (14%) 6 (12%) 9 (19%) 4 (8%)
Necrosis 1 (2%) 2 (4%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%) 3 (6%)
Adrenal Medulla (49) (49) (47) (49)
Hyperplasia 26 (53%) 13 (27%) 23 (49%) 12 (24%)
Necrosis 1 (2%)
Islets, Pancreatic (49) (49) (48) (49)
Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Pituitary Gland (49) (49) (47) (49)
Angiectasis 1 (2%) 1 (2%)
Cyst 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 11 (22%) 12 (24%) 10 (21%) 15 (31%)
Thyroid Gland (46) (47) (45) (47)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05110-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 02/18/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:59:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 PPM 30 PPM 60 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
C-Cell, Hyperplasia 32 (70%) 36 (77%) 31 (69%) 33 (70%)
Follicular Cell, Hyperplasia 2 (4%) 3 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (49) (48) (49)
Angiectasis 1 (2%)
Granuloma Sperm 1 (2%)
Preputial Gland (48) (49) (47) (49)
Cyst 1 (2%) 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (4%) 2 (4%)
Prostate (49) (49) (48) (49)
Hyperplasia 11 (22%) 8 (16%) 16 (33%) 8 (16%)
Inflammation, Chronic Active 3 (6%) 2 (4%) 3 (6%) 2 (4%)
Epithelium, Hyperplasia 1 (2%)
Seminal Vesicle (47) (49) (47) (47)
Inflammation, Chronic Active 1 (2%)
Testes (49) (49) (48) (49)
Atrophy 2 (4%) 4 (8%) 2 (4%) 4 (8%)
Artery, Inflammation, Chronic Active 2 (4%) 2 (4%)
Interstitial Cell, Hyperplasia 5 (10%) 9 (18%) 2 (4%) 11 (22%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (3) (3) (8) (4)
Iliac, Hemorrhage 1 (33%)
Lymph Node, Mandibular (40) (45) (46) (44)
Infiltration Cellular, Plasma Cell 1 (3%) 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (3%)
Spleen (49) (49) (48) (49)
Fibrosis 7 (14%) 12 (24%) 6 (13%) 6 (12%)
Hematopoietic Cell Proliferation 4 (8%) 3 (6%) 1 (2%) 4 (8%)
Hemorrhage 3 (6%) 1 (2%) 2 (4%) 2 (4%)
Necrosis 3 (6%) 2 (4%) 1 (2%) 2 (4%)
Thrombosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05110-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 02/18/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:59:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 PPM 30 PPM 60 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (21) (20) (30) (28)
Galactocele 1 (3%)
Skin (48) (48) (48) (48)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 4 (8%) 2 (4%) 1 (2%)
Hyperplasia, Basal Cell 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 4 (8%) 1 (2%)
Epithelium, Hyperplasia, Basal Cell 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (49) (48) (49)
Osteopetrosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (49) (48) (49)
Degeneration 1 (2%) 1 (2%)
Necrosis 1 (2%)
Artery, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (49) (48) (49)
Metaplasia, Squamous 1 (2%) 2 (4%)
Lung (49) (49) (48) (49)
Cyst, Squamous 1 (2%)
Foreign Body 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 2 (4%) 13 (27%) 6 (13%) 15 (31%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 23 (47%) 12 (24%) 9 (19%) 16 (33%)
Alveolar Epithelium, Metaplasia 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 12 (24%) 9 (18%) 6 (13%) 15 (31%)
Bronchiole, Hyperplasia 1 (2%) 1 (2%)
Nose (49) (49) (48) (48)
Foreign Body 1 (2%)
Inflammation, Suppurative 12 (24%) 18 (37%) 16 (33%) 9 (19%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05110-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 02/18/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:59:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 PPM 30 PPM 60 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Thrombosis 6 (12%) 7 (14%) 6 (13%) 3 (6%)
Glands, Hyperplasia 1 (2%) 49 (100%) 48 (100%) 48 (100%)
Glands, Metaplasia, Squamous 3 (6%) 14 (29%) 26 (54%)
Goblet Cell, Respiratory Epithelium,
Hyperplasia 25 (51%) 29 (60%) 26 (54%)
Olfactory Epithelium, Atrophy 3 (6%) 49 (100%) 48 (100%) 47 (98%)
Olfactory Epithelium, Degeneration, Hyaline 3 (6%) 45 (92%) 40 (83%) 38 (79%)
Olfactory Epithelium, Hyperplasia, Atypical 48 (98%) 45 (94%) 46 (96%)
Olfactory Epithelium, Inflammation, Chronic 49 (100%) 48 (100%) 48 (100%)
Respiratory Epithelium, Degeneration, Hyaline 20 (41%) 19 (40%) 19 (40%)
Respiratory Epithelium, Hyperplasia 3 (6%) 21 (43%) 29 (60%) 29 (60%)
Respiratory Epithelium, Metaplasia, Squamous 15 (31%) 23 (48%) 18 (38%)
Trachea (49) (49) (48) (49)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (48) (48) (48) (48)
Cataract 4 (8%) 2 (4%) 1 (2%) 3 (6%)
Hemorrhage 1 (2%)
Inflammation, Suppurative 1 (2%)
Retina, Atrophy 2 (4%) 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (49) (48) (49)
Infarct 3 (6%) 1 (2%) 3 (6%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 1 (2%)
Nephropathy 43 (88%) 44 (90%) 45 (94%) 43 (88%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%)
Urinary Bladder (48) (49) (48) (49)
Hemorrhage 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------