TDMS Study 05110-02 Pathology Tables
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
FINAL#2, CORE STUDY RATS
Facility: Battelle Northwest
Chemical CAS #: 91-20-3
Lock Date: 01/05/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 7| 2| 7| 0| 3| 3| 3| 3| 3| 7| 1| 7| 3| 5| 3|
| 4| 4| 5| 4| 6| 4| 5| 4| 5| 5| 9| 7| 6| 2| 6| 5| 6| 5| 5| 7| 3| 1| 5| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Eosinophilic Focus | |
Fatty Change | 2 2 2 1 2 |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic | 2 |
Mixed Cell Focus | X |
Necrosis | 2 |
Regeneration | |
Vacuolization Cytoplasmic, Focal | 3 |
Bile Duct, Hyperplasia | 2 1 2 |
Centrilobular, Necrosis | 1 2 2 2 2 1 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Hemorrhage | 2 |
Fat, Necrosis | 3 3 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 1 1 2 1 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Basophilic Focus | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Necrosis | 2 1 |
Ulcer | 3 |
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 3 2 2 1 1 2 1 1 2 1 1|
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 7| 2| 7| 0| 3| 3| 3| 3| 3| 7| 1| 7| 3| 5| 3|
| 4| 4| 5| 4| 6| 4| 5| 4| 5| 5| 9| 7| 6| 2| 6| 5| 6| 5| 5| 7| 3| 1| 5| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Degeneration, Cystic | 3 4 2 |
Hyperplasia | 2 2 2 2 2 2 2 2 3 2 2 2 2|
Hypertrophy | 1 3 2 2 2 2 |
Necrosis | 2 3 4 |
Thrombosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 4 2 |
Necrosis | 4 |
Thrombosis | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + + + + M + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Hyperplasia | 2 3 3 2 4 2 4 3 4 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 1 4 2 2 2 2 3 2 2 2 2 3 3 2 3 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 3 1 |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + M + + + M + + + + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + M + M + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 7| 2| 7| 0| 3| 3| 3| 3| 3| 7| 1| 7| 3| 5| 3|
| 4| 4| 5| 4| 6| 4| 5| 4| 5| 5| 9| 7| 6| 2| 6| 5| 6| 5| 5| 7| 3| 1| 5| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 4 |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Inflammation, Chronic Active | 3 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epidermis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 4 3 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 1 4 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 2 |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Thrombosis | 3 4 4 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 1 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 4 4 |
Cornea, Infiltration Cellular, | |
Polymorphonuclear | 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 7| 2| 7| 0| 3| 3| 3| 3| 3| 7| 1| 7| 3| 5| 3|
| 4| 4| 5| 4| 6| 4| 5| 4| 5| 5| 9| 7| 6| 2| 6| 5| 6| 5| 5| 7| 3| 1| 5| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 2 2 2 2 2 2 1 2 1 1 1 4 1 1 1 2 1 3 1 2 2|
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| | |
DAY ON TEST | 3| 1| 3| 7| 7| 3| 0| 9| 0| 3| 2| 7| 3| 3| 8| 3| 0| 3| 3| 5| 3| 3| 3| 2| | |
| 5| 9| 4| 2| 1| 5| 9| 0| 7| 5| 5| 1| 5| 5| 4| 5| 4| 5| 4| 7| 5| 6| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + I + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | 3 | 2 3.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X | 46 |
Clear Cell Focus | X X X X X | 7 |
Eosinophilic Focus | X | 1 |
Fatty Change | 1 2 2 3 3 | 10 2.0|
Hepatodiaphragmatic Nodule | | 4 |
Inflammation, Chronic | 2 | 2 2.0|
Mixed Cell Focus | X X X X X | 6 |
Necrosis | | 1 2.0|
Regeneration | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 1 3.0|
Bile Duct, Hyperplasia | 1 2 | 5 1.6|
Centrilobular, Necrosis | 1 3 1 1 | 11 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 13 |
Fat, Hemorrhage | | 1 2.0|
Fat, Necrosis | 3 2 2 3 2 2 2 2 | 13 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 1 2 1 1 2 2 1 2 2 2 | 18 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | | 1 2.0|
Basophilic Focus | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Acute | | 1 2.0|
Ulcer | 4 2 | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Mineralization | 1 | 2 1.0|
Necrosis | 1 | 3 1.3|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| | |
DAY ON TEST | 3| 1| 3| 7| 7| 3| 0| 9| 0| 3| 2| 7| 3| 3| 8| 3| 0| 3| 3| 5| 3| 3| 3| 2| | |
| 5| 9| 4| 2| 1| 5| 9| 0| 7| 5| 5| 1| 5| 5| 4| 5| 4| 5| 4| 7| 5| 6| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cardiomyopathy | 1 1 2 2 1 1 1 2 1 3 2 1 2 2 1 1 2 | 32 1.5|
Atrium, Thrombosis | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 2 | 2 2.5|
Degeneration, Cystic | 3 | 4 3.0|
Hyperplasia | 2 2 2 1 2 2 2 2 2 2 | 23 2.0|
Hypertrophy | 2 | 7 2.0|
Necrosis | 1 | 4 2.5|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 2 3 4 2 | 10 2.6|
Necrosis | 2 | 2 3.0|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + M + + + + M | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | 3 | 2 2.5|
Pars Distalis, Hyperplasia | 3 3 3 2 3 2 2 3 2 2 3 4 4 | 24 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + A + + + + + A + + + + + + + | 47 |
C-Cell, Hyperplasia | 2 1 2 1 2 2 1 2 3 2 2 3 1 1 2 2 1 1 | 39 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cyst | 2 2 3 3 | 7 2.6|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| | |
DAY ON TEST | 3| 1| 3| 7| 7| 3| 0| 9| 0| 3| 2| 7| 3| 3| 8| 3| 0| 3| 3| 5| 3| 3| 3| 2| | |
| 5| 9| 4| 2| 1| 5| 9| 0| 7| 5| 5| 1| 5| 5| 4| 5| 4| 5| 4| 7| 5| 6| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia, Reticulum Cell | 2 | 1 2.0|
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + + + M + M + + + + + | 42 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + M + + + + + | 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + + + + M + + + + + + A + M + + + + M | 40 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Fibrosis | 2 3 | 3 2.3|
Hematopoietic Cell Proliferation | 2 | 2 3.0|
Necrosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + A + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Galactocele | 2 | 1 2.0|
Inflammation, Chronic Active | | 2 3.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic Active | 2 | 1 2.0|
Epidermis, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Osteopetrosis | 1 3 2 3 2 3 | 10 2.4|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Degeneration | | 1 2.0|
Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Metaplasia, Squamous | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 | 16 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 4 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 2 1 1 2 1 1 | 19 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| | |
DAY ON TEST | 3| 1| 3| 7| 7| 3| 0| 9| 0| 3| 2| 7| 3| 3| 8| 3| 0| 3| 3| 5| 3| 3| 3| 2| | |
| 5| 9| 4| 2| 1| 5| 9| 0| 7| 5| 5| 1| 5| 5| 4| 5| 4| 5| 4| 7| 5| 6| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Bronchiole, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Suppurative | 1 1 | 2 1.0|
Thrombosis | 1 4 3 3 | 7 3.1|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 1 1 1 1 | 13 1.1|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + A + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cataract | 2 3 4 | 5 3.4|
Cornea, Infiltration Cellular, | | |
Polymorphonuclear | 1 | 2 1.0|
Retina, Atrophy | 2 4 4 | 5 3.6|
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + A + + + + + + + + + + + + + | 48 |
Nephropathy | 2 1 1 1 1 2 1 1 1 2 2 1 2 3 2 1 1 1 | 41 1.6|
Renal Tubule, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + I | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 6| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 7| 3| 3| 3| 3| 0| 6| 9| 7| 6| 4| 8| 4| 2| 3| 2| 3| 3| 3| 3| 3| 3|
| 6| 1| 4| 7| 5| 4| 4| 4| 9| 5| 9| 7| 3| 0| 7| 7| 6| 5| 3| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X |
Fatty Change | 3 2 2 |
Hepatodiaphragmatic Nodule | |
Mixed Cell Focus | X X |
Necrosis | |
Regeneration | 3 |
Vacuolization Cytoplasmic, Focal | 2 |
Bile Duct, Hyperplasia | 3 |
Centrilobular, Necrosis | 1 1 3 2 |
__________________________________________________________________________|
Mesentery | + + + + + +|
Fat, Inflammation | |
Fat, Necrosis | 2 2 2 3 3 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 |
Basophilic Focus | |
Hyperplasia | |
Duct, Cyst | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 |
Necrosis | 4 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 1 1 1 1 1 2 1 1 2 1 2|
Atrium, Thrombosis | 3 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 |
Hyperplasia | 2 2 1 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 6| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 7| 3| 3| 3| 3| 0| 6| 9| 7| 6| 4| 8| 4| 2| 3| 2| 3| 3| 3| 3| 3| 3|
| 6| 1| 4| 7| 5| 4| 4| 4| 9| 5| 9| 7| 3| 0| 7| 7| 6| 5| 3| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy | 2 4 |
Necrosis | 2 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Necrosis | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + M M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 3 |
Pars Distalis, Hyperplasia | 2 4 3 3 4 4 3 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 3 1 3 1 2 2 1 2 1 4 1 2 1 1 1 1 4 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 1 3 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M + + + M + M + + M + + M + + M M + + + + M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + M + + + + M + + + M + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + M + M + + M + + M + + + M + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 4 |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 2|
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 6| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 7| 3| 3| 3| 3| 0| 6| 9| 7| 6| 4| 8| 4| 2| 3| 2| 3| 3| 3| 3| 3| 3|
| 6| 1| 4| 7| 5| 4| 4| 4| 9| 5| 9| 7| 3| 0| 7| 7| 6| 5| 3| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 4 1 1 1 1 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 1 1 |
Bronchiole, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Thrombosis | 2 4 |
Glands, Hyperplasia | 1 1 2 2 2 2 3 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2|
Glands, Metaplasia, Squamous | 2 |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 1 1 1 1 1 1 1 1 1 1|
Olfactory Epithelium, Atrophy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 1 3 2 1 1 2 2 2|
Olfactory Epithelium, Degeneration, | |
Hyaline | 3 1 3 2 3 2 2 2 2 1 1 1 1 1 2 3 1 2 1 2 2 2 2 2|
Olfactory Epithelium, Hyperplasia, | |
Atypical | 2 1 2 2 2 2 2 1 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Olfactory Epithelium, Inflammation, | |
Chronic | 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 1 2 2 1 2 2 1 2 1 1 2 2 1 1 1|
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 2 1 3 4 1 1 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 2 1 1 2 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 4 4 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 6| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 7| 3| 3| 3| 3| 0| 6| 9| 7| 6| 4| 8| 4| 2| 3| 2| 3| 3| 3| 3| 3| 3|
| 6| 1| 4| 7| 5| 4| 4| 4| 9| 5| 9| 7| 3| 0| 7| 7| 6| 5| 3| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 2 1 1 2 1 1 2 1 1 1 1 1 1 2 1 2 2 2|
Renal Tubule, Necrosis | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 6| 5| 7| 6| 7| 4| 6| 7| 5| 6| 7| 6| 5| 7| 7| 7| 7| 5| 6| 6| 7| | |
DAY ON TEST | 7| 8| 3| 2| 0| 3| 0| 1| 7| 3| 3| 7| 2| 3| 7| 1| 3| 3| 2| 3| 0| 7| 7| 3| | |
| 7| 1| 5| 5| 9| 5| 2| 3| 1| 5| 4| 4| 2| 6| 9| 8| 5| 6| 1| 5| 3| 9| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | 3 2 | 4 2.3|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X | 44 |
Clear Cell Focus | X X X X X | 16 |
Fatty Change | | 3 2.3|
Hepatodiaphragmatic Nodule | X | 1 |
Mixed Cell Focus | X X X X | 6 |
Necrosis | 2 | 1 2.0|
Regeneration | 2 | 2 2.5|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 2 1 1 2 | 5 1.8|
Centrilobular, Necrosis | 2 3 1 1 2 1 2 | 11 1.7|
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Fat, Inflammation | 2 | 1 2.0|
Fat, Necrosis | 3 | 7 2.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 2 1 1 1 2 | 9 1.2|
Basophilic Focus | X | 1 |
Hyperplasia | 2 | 1 2.0|
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Ulcer | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + | 48 |
Mineralization | | 2 1.0|
Necrosis | 1 | 2 2.5|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cardiomyopathy | 2 2 1 1 1 1 2 1 1 1 1 2 1 1 1 2 | 31 1.3|
Atrium, Thrombosis | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 6| 5| 7| 6| 7| 4| 6| 7| 5| 6| 7| 6| 5| 7| 7| 7| 7| 5| 6| 6| 7| | |
DAY ON TEST | 7| 8| 3| 2| 0| 3| 0| 1| 7| 3| 3| 7| 2| 3| 7| 1| 3| 3| 2| 3| 0| 7| 7| 3| | |
| 7| 1| 5| 5| 9| 5| 2| 3| 1| 5| 4| 4| 2| 6| 9| 8| 5| 6| 1| 5| 3| 9| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Degeneration, Cystic | 2 2 | 4 2.3|
Hyperplasia | 2 2 1 2 | 12 1.8|
Hypertrophy | 2 2 | 4 2.5|
Necrosis | | 2 2.0|
Vacuolization Cytoplasmic | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 2 1 2 | 3 1.7|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + M + + + + + M + + + + + + M + M + + + M | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | | 2 3.5|
Pars Distalis, Hyperplasia | 4 1 4 3 2 | 13 3.2|
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + A + + + + + + + + + + + + + + + + + | 46 |
C-Cell, Hyperplasia | 2 2 2 1 1 3 2 3 1 2 2 2 2 2 2 3 | 37 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cyst | 3 3 4 3 2 | 9 2.7|
Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node | + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + M + M + + M + M + + + + M + + M + + + + | 33 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + M M M + + + + + + + + M + + + | 39 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + M M + M + + + + + + M + + + + + + + | 39 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Fibrosis | 2 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 6| 5| 7| 6| 7| 4| 6| 7| 5| 6| 7| 6| 5| 7| 7| 7| 7| 5| 6| 6| 7| | |
DAY ON TEST | 7| 8| 3| 2| 0| 3| 0| 1| 7| 3| 3| 7| 2| 3| 7| 1| 3| 3| 2| 3| 0| 7| 7| 3| | |
| 7| 1| 5| 5| 9| 5| 2| 3| 1| 5| 4| 4| 2| 6| 9| 8| 5| 6| 1| 5| 3| 9| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 4 3 2 | 4 3.0|
Hemorrhage | 4 | 2 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M M + + + + + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Galactocele | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Subcutaneous Tissue, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Osteopetrosis | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic Active | 1 1 1 1 1 1 | 15 1.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 4 1 | 11 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 | 7 1.1|
Bronchiole, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Suppurative | 2 1 2 3 2 | 5 2.0|
Thrombosis | 2 4 | 4 3.0|
Glands, Hyperplasia | 2 1 2 2 1 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 | 48 1.9|
Glands, Metaplasia, Squamous | 2 | 2 2.0|
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 1 1 1 1 1 1 | 16 1.0|
Olfactory Epithelium, Atrophy | 2 2 2 2 2 2 2 2 1 2 1 2 2 2 3 2 1 2 2 1 2 2 2 2 | 49 1.9|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 3 2 1 2 2 1 1 2 2 2 1 2 1 3 3 1 1 1 2 1 | 46 1.8|
Olfactory Epithelium, Hyperplasia, | | |
Atypical | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 48 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 6| 5| 7| 6| 7| 4| 6| 7| 5| 6| 7| 6| 5| 7| 7| 7| 7| 5| 6| 6| 7| | |
DAY ON TEST | 7| 8| 3| 2| 0| 3| 0| 1| 7| 3| 3| 7| 2| 3| 7| 1| 3| 3| 2| 3| 0| 7| 7| 3| | |
| 7| 1| 5| 5| 9| 5| 2| 3| 1| 5| 4| 4| 2| 6| 9| 8| 5| 6| 1| 5| 3| 9| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Inflammation, | | |
Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 1 2 2 | 47 1.9|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 1 1 1 1 1 1 1 1 1 1 1 1 | 33 1.2|
Respiratory Epithelium, Hyperplasia | 3 1 1 2 2 1 | 18 1.6|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 2 2 1 2 2 2 2 1 2 2 2 | 21 1.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cataract | | 2 4.0|
Retina, Atrophy | | 2 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cyst | 2 | 1 2.0|
Nephropathy | 4 2 2 1 1 2 2 1 2 2 2 1 1 2 1 2 1 2 1 3 | 38 1.6|
Renal Tubule, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 7| 7| 5| 5| 7| 4| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 1| 3| 3| 7| 8| 2| 3| 1| 8| 8| 3| 4| 9| 4| 3| 3| 3| 3|
| 4| 5| 5| 5| 4| 3| 5| 2| 4| 6| 1| 5| 4| 4| 5| 7| 7| 4| 0| 9| 0| 5| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X X X |
Fatty Change | 3 |
Hepatodiaphragmatic Nodule | X X X X |
Mixed Cell Focus | X X X X X X |
Necrosis | |
Regeneration | 2 |
Bile Duct, Hyperplasia | 1 2 2 |
Centrilobular, Necrosis | 1 1 1 |
Hepatocyte, Atrophy | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 2 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 1|
Basophilic Focus | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Necrosis | |
Ulcer | |
__________________________________________________________________________|
Tooth | + |
Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 1 1 1 1 1 3 1 1 1 1 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 |
Hyperplasia | 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 7| 7| 5| 5| 7| 4| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 1| 3| 3| 7| 8| 2| 3| 1| 8| 8| 3| 4| 9| 4| 3| 3| 3| 3|
| 4| 5| 5| 5| 4| 3| 5| 2| 4| 6| 1| 5| 4| 4| 5| 7| 7| 4| 0| 9| 0| 5| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy | 2 1 2 1 1 2 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M M M + + + + M + + + + + M M M + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Hyperplasia | 3 3 3 4 2 3 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 2 2 2 1 1 1 1 2 2 2 2 1 1 1|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 2 4 3 1|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Vagina | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + M + M + M + M + M + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + + + + + + M + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 3 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 7| 7| 5| 5| 7| 4| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 1| 3| 3| 7| 8| 2| 3| 1| 8| 8| 3| 4| 9| 4| 3| 3| 3| 3|
| 4| 5| 5| 5| 4| 3| 5| 2| 4| 6| 1| 5| 4| 4| 5| 7| 7| 4| 0| 9| 0| 5| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 3 1 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 1 2 1 1 1 1 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 4 1 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 3 |
Thrombosis | 4 |
Glands, Hyperplasia | 3 3 2 3 3 2 4 3 3 3 4 3 3 2 2 3 3 4 3 3 3 3 3 3 3|
Glands, Metaplasia, Squamous | 2 3 2 2 4 2 2 1 3 3 2 1|
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 1 1 1 1 1 1 1 2 1 2 1 1 1 1 2 1 1 |
Olfactory Epithelium, Atrophy | 3 3 2 3 2 2 2 3 2 3 3 3 2 3 2 3 3 3 3 3 3 3 3 3 2|
Olfactory Epithelium, Degeneration, | |
Hyaline | 3 3 2 2 3 2 2 1 3 2 2 2 2 2 2 1 2 3 1 2 2 3 2 3 3|
Olfactory Epithelium, Hyperplasia, | |
Atypical | 2 3 3 2 2 2 2 3 2 2 2 2 2 3 2 2 2 3 3 2 2 2 2 3 2|
Olfactory Epithelium, Inflammation, | |
Chronic | 2 2 2 3 3 2 3 3 3 3 3 3 2 2 2 2 3 3 3 2 3 3 3 3|
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 2 1 2 2 1 1 1 2 1 1 2 1 2 1 2|
Respiratory Epithelium, Hyperplasia | 2 1 2 2 1 2 2 2 2 1 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 1 1 1 2 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 7| 7| 5| 5| 7| 4| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 1| 3| 3| 7| 8| 2| 3| 1| 8| 8| 3| 4| 9| 4| 3| 3| 3| 3|
| 4| 5| 5| 5| 4| 3| 5| 2| 4| 6| 1| 5| 4| 4| 5| 7| 7| 4| 0| 9| 0| 5| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 1 1 4 |
Retina, Atrophy | 2 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy | 2 1 2 2 2 1 1 1 2 2 2 2 1 1 1 2 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5| 5| 4| 6| 7| 7| 6| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 3| 8| 8| 8| 5| 3| 3| 6| 3| | |
| 5| 5| 5| 6| 4| 4| 5| 4| 5| 1| 5| 4| 7| 8| 0| 5| 6| 1| 0| 3| 5| 4| 0| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + A + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | | 2 1.5|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X | 46 |
Clear Cell Focus | X X X X X | 8 |
Eosinophilic Focus | X | 6 |
Fatty Change | 3 | 2 3.0|
Hepatodiaphragmatic Nodule | X X | 6 |
Mixed Cell Focus | X | 7 |
Necrosis | 2 | 1 2.0|
Regeneration | 2 | 2 2.0|
Bile Duct, Hyperplasia | 1 1 | 5 1.4|
Centrilobular, Necrosis | 2 2 1 1 | 7 1.3|
Hepatocyte, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Fat, Necrosis | 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 2 1 3 1 1 1 1 | 11 1.4|
Basophilic Focus | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Ulcer | 4 | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | | 1 3.0|
Necrosis | 3 | 1 3.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cardiomyopathy | 1 2 2 1 1 2 1 2 1 1 1 1 3 1 1 1 1 | 31 1.3|
Atrium, Thrombosis | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5| 5| 4| 6| 7| 7| 6| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 3| 8| 8| 8| 5| 3| 3| 6| 3| | |
| 5| 5| 5| 6| 4| 4| 5| 4| 5| 1| 5| 4| 7| 8| 0| 5| 6| 1| 0| 3| 5| 4| 0| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Degeneration, Cystic | 2 | 3 2.0|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 | 18 2.0|
Hypertrophy | 2 4 1 2 | 12 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 1 1 2 2 2 2 | 9 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + | 41 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | 3 4 | 3 3.0|
Pars Distalis, Hyperplasia | 2 2 3 2 3 2 3 2 | 18 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + A + + + + + + + + + + + | 48 |
C-Cell, Hyperplasia | 2 1 2 2 2 2 1 2 2 1 1 3 3 1 1 1 1 2 2 | 37 1.5|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | | 2 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cyst | 3 2 2 2 3 | 11 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Vagina | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia, Reticulum Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + M M + + + + + M + + M + M M M + M + + + | 34 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5| 5| 4| 6| 7| 7| 6| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 3| 8| 8| 8| 5| 3| 3| 6| 3| | |
| 5| 5| 5| 6| 4| 4| 5| 4| 5| 1| 5| 4| 7| 8| 0| 5| 6| 1| 0| 3| 5| 4| 0| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + + + + + + M M + + + M + + + + + + + M + | 41 |
Congestion | 3 | 1 3.0|
Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Fibrosis | 2 2 | 3 1.7|
Hematopoietic Cell Proliferation | | 1 3.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Galactocele | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Osteopetrosis | 3 3 2 | 7 2.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Metaplasia, Squamous | 2 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Congestion, Chronic | 3 | 1 3.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 | 19 1.1|
Metaplasia, Osseous | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 4 2 1 1 | 11 1.6|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 | 11 1.0|
Bronchiole, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Suppurative | 1 2 | 5 1.6|
Thrombosis | 1 1 | 3 2.0|
Glands, Hyperplasia | 3 3 4 3 4 3 3 4 4 3 4 4 3 3 3 3 3 2 3 3 3 3 3 | 48 3.1|
Glands, Metaplasia, Squamous | 3 3 2 3 4 3 2 2 | 21 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5| 5| 4| 6| 7| 7| 6| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 3| 8| 8| 8| 5| 3| 3| 6| 3| | |
| 5| 5| 5| 6| 4| 4| 5| 4| 5| 1| 5| 4| 7| 8| 0| 5| 6| 1| 0| 3| 5| 4| 0| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 1 2 1 1 1 1 2 2 1 1 1 1 | 29 1.2|
Olfactory Epithelium, Atrophy | 2 3 2 3 3 3 3 3 3 2 2 2 3 3 3 2 4 3 3 3 2 3 3 2 | 49 2.7|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 3 2 3 3 3 3 2 2 2 2 2 2 1 2 2 1 2 1 2 2 1 2 2 2 | 49 2.1|
Olfactory Epithelium, Hyperplasia, | | |
Atypical | 2 2 2 2 4 3 3 3 3 2 3 2 3 3 2 2 3 2 2 3 3 3 2 | 48 2.4|
Olfactory Epithelium, Inflammation, | | |
Chronic | 2 2 3 2 3 3 3 3 3 2 3 3 2 2 2 3 2 2 3 3 3 3 3 | 47 2.6|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 1 2 2 2 1 1 1 2 1 2 1 2 1 1 1 1 1 | 34 1.4|
Respiratory Epithelium, Hyperplasia | 2 2 1 3 2 4 2 2 1 1 2 | 22 1.9|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 2 1 2 1 1 2 | 17 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + A + + + + + + + + + + + | 46 |
Cataract | 4 4 3 | 6 2.8|
Retina, Atrophy | 4 4 | 4 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Infarct | 3 | 1 3.0|
Nephropathy | 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 | 34 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 4| 7| 7| 6| 7| 1| 4| 7| 7|
DAY ON TEST | 4| 7| 3| 2| 3| 8| 3| 3| 2| 2| 3| 1| 3| 8| 3| 6| 2| 3| 3| 7| 3| 1| 7| 3| 3|
| 7| 9| 5| 4| 6| 5| 5| 5| 2| 5| 5| 7| 5| 4| 6| 7| 9| 5| 5| 7| 5| 1| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
60 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + I + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Cyst | 2 |
Eosinophilic Focus | X |
Fatty Change | 2 3 |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | X X X |
Regeneration | 3 |
Bile Duct, Hyperplasia | 2 2 2 2 |
Centrilobular, Necrosis | 2 1 2 1 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + |
Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 1 2 1 1 2 1 1 1 2 1 2 1|
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia | 2 1 2 2 2 2 1 2 2 2 2 2|
Hypertrophy | 2 1 2 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 4| 7| 7| 6| 7| 1| 4| 7| 7|
DAY ON TEST | 4| 7| 3| 2| 3| 8| 3| 3| 2| 2| 3| 1| 3| 8| 3| 6| 2| 3| 3| 7| 3| 1| 7| 3| 3|
| 7| 9| 5| 4| 6| 5| 5| 5| 2| 5| 5| 7| 5| 4| 6| 7| 9| 5| 5| 7| 5| 1| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
60 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Necrosis | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
Angiectasis | 2 |
Cyst | 2 |
Pars Distalis, Hyperplasia | 1 3 3 3 3 1 4 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 3 1 2 2 2 2 2 3 2 3 3 1 1 1 1 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 2 2 |
Inflammation, Granulomatous | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + M + + M + M + + M + + + + + + M + + + M M|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M + M + M M + + + + M M M M M M M M + M + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 2 2 2 |
Hemorrhage | 3 |
Metaplasia, Osseous | 2 |
Necrosis | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + M + + + + + + M + + M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 4| 7| 7| 6| 7| 1| 4| 7| 7|
DAY ON TEST | 4| 7| 3| 2| 3| 8| 3| 3| 2| 2| 3| 1| 3| 8| 3| 6| 2| 3| 3| 7| 3| 1| 7| 3| 3|
| 7| 9| 5| 4| 6| 5| 5| 5| 2| 5| 5| 7| 5| 4| 6| 7| 9| 5| 5| 7| 5| 1| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
60 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia, Atypical | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 2 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 2 1 3 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 2 1 |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 1 2 |
Thrombosis | 4 3 |
Glands, Hyperplasia | 3 3 4 3 3 4 3 4 3 3 4 3 4 3 3 4 3 4 2 3 4 3|
Glands, Metaplasia, Squamous | 3 2 2 2 2 2 4 3 3 4 |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1|
Olfactory Epithelium, Atrophy | 3 3 3 4 3 4 3 2 4 3 3 3 3 2 3 3 3 3 4 2 2 3 4 3|
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 2 2 2 3 3 3 2 2 2 1 3 2 3 3 1 3 2 1 2 1 3 3|
Olfactory Epithelium, Hyperplasia, | |
Atypical | 4 3 2 3 3 4 3 2 3 3 2 3 3 3 2 2 3 1 3 2 3 3 3|
Olfactory Epithelium, Inflammation, | |
Chronic | 4 3 2 4 4 4 3 3 4 4 3 4 4 4 3 2 3 4 4 4 2 3 4 4|
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 1 1 2 1 2 1 1 1|
Respiratory Epithelium, Hyperplasia | 2 2 3 3 1 2 1 2 4 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 3 2 1 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 4| 7| 7| 6| 7| 1| 4| 7| 7|
DAY ON TEST | 4| 7| 3| 2| 3| 8| 3| 3| 2| 2| 3| 1| 3| 8| 3| 6| 2| 3| 3| 7| 3| 1| 7| 3| 3|
| 7| 9| 5| 4| 6| 5| 5| 5| 2| 5| 5| 7| 5| 4| 6| 7| 9| 5| 5| 7| 5| 1| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
60 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 3 2 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Nephropathy | 1 2 1 1 1 2 1 1 1 2 2 2 2 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 5| 6| 7| 6| 4| 6| 4| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 8| 2| 5| 0| 0| 3| 5| 4| 2| 8| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 0| 0| 5| 3| 1| 6| 6| 5| 5| 2| 3| 5| 6| 5| 2| 6| 4| 4| 6| 4| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
60 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + I + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + A + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + A + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X | 44 |
Clear Cell Focus | X X | 6 |
Cyst | | 1 2.0|
Eosinophilic Focus | X | 2 |
Fatty Change | 2 3 | 4 2.5|
Hepatodiaphragmatic Nodule | X X | 5 |
Mixed Cell Focus | X X X | 6 |
Regeneration | 3 | 2 3.0|
Bile Duct, Hyperplasia | 2 2 | 6 2.0|
Centrilobular, Necrosis | 1 2 1 | 9 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Fat, Necrosis | 2 2 3 | 5 2.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 2 2 2 1 | 10 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 1 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Mineralization | 1 | 2 1.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cardiomyopathy | 3 1 1 1 1 1 1 2 1 1 2 2 1 1 1 1 1 2 | 34 1.3|
Atrium, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 5| 6| 7| 6| 4| 6| 4| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 8| 2| 5| 0| 0| 3| 5| 4| 2| 8| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 0| 0| 5| 3| 1| 6| 6| 5| 5| 2| 3| 5| 6| 5| 2| 6| 4| 4| 6| 4| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
60 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Degeneration, Cystic | 2 2 2 | 3 2.0|
Hyperplasia | 1 2 2 2 2 2 2 2 2 2 2 2 | 24 1.9|
Hypertrophy | 2 1 | 6 1.7|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | 2 | 2 2.0|
Cyst | | 1 2.0|
Pars Distalis, Hyperplasia | 4 4 1 3 3 2 2 | 15 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + A + + + + + + + + + + + + + + + + + + + + + | 48 |
C-Cell, Hyperplasia | 2 1 2 1 1 2 1 1 1 1 1 1 2 1 2 1 1 1 1 2 1 2 | 42 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 3 2 | 3 2.7|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cyst | 2 3 2 2 | 8 2.4|
Inflammation, Granulomatous | 4 | 2 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + M M + + + + + + + + + + + M M + | 36 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + M + + + + + + + + + M M + + + + + + + | 31 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 5| 6| 7| 6| 4| 6| 4| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 8| 2| 5| 0| 0| 3| 5| 4| 2| 8| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 0| 0| 5| 3| 1| 6| 6| 5| 5| 2| 3| 5| 6| 5| 2| 6| 4| 4| 6| 4| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
60 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis | | 2 2.0|
Hematopoietic Cell Proliferation | 3 | 4 2.3|
Hemorrhage | | 1 3.0|
Metaplasia, Osseous | | 1 2.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + M + + + + M + + + + + + + + + + + + + | 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Galactocele | 3 | 1 3.0|
Hyperplasia, Atypical | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperkeratosis | 4 | 1 4.0|
Inflammation, Acute | 4 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Osteopetrosis | 3 2 2 | 5 2.6|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 2 | 1 2.0|
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 | 22 1.0|
Alveolar Epithelium, Hyperplasia | 1 3 1 | 9 1.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 | 14 1.1|
Bronchiole, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Suppurative | 2 | 5 1.6|
Thrombosis | 1 | 3 2.7|
Glands, Hyperplasia | 3 4 2 2 4 3 3 2 3 3 3 3 4 4 4 4 4 3 3 4 | 42 3.3|
Glands, Metaplasia, Squamous | 2 3 2 2 4 4 4 3 2 2 | 20 2.8|
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 1 1 1 1 1 1 1 1 1 | 20 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 5| 6| 7| 6| 4| 6| 4| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 8| 2| 5| 0| 0| 3| 5| 4| 2| 8| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 0| 0| 5| 3| 1| 6| 6| 5| 5| 2| 3| 5| 6| 5| 2| 6| 4| 4| 6| 4| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
60 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Atrophy | 3 4 3 3 3 3 4 4 4 3 4 3 3 3 4 3 4 3 4 3 3 3 2 | 47 3.2|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 3 2 3 2 2 2 2 1 1 1 1 3 1 3 4 2 2 2 2 3 3 | 45 2.1|
Olfactory Epithelium, Hyperplasia, | | |
Atypical | 3 3 2 3 4 3 3 3 4 3 4 3 3 2 3 2 3 3 3 4 | 43 2.9|
Olfactory Epithelium, Inflammation, | | |
Chronic | 4 3 4 3 4 4 3 3 3 3 3 3 3 4 3 4 3 4 3 4 4 | 45 3.4|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 1 2 1 2 1 2 1 1 1 1 1 1 1 1 | 28 1.2|
Respiratory Epithelium, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 4 1 | 23 1.7|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 1 2 1 2 1 3 | 15 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cataract | 4 | 3 3.0|
Retina, Atrophy | 3 | 2 3.5|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Infarct | | 1 3.0|
Nephropathy | 2 1 1 1 1 1 1 1 1 1 3 1 2 1 2 | 31 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 5| 7| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 0| 1| 3| 9| 3| 3| 5| 3| 3| 3| 3| 2| 3| 0| 9| 3| 1| 7| 7|
| 4| 3| 3| 9| 3| 2| 8| 6| 9| 5| 3| 3| 7| 3| 3| 4| 4| 6| 4| 3| 2| 3| 3| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X |
Degeneration, Cystic | 2 |
Eosinophilic Focus | X |
Fatty Change | 1 2 |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X |
Regeneration | |
Artery, Inflammation | 3 |
Bile Duct, Hyperplasia | 1 2 1 2 2 2 2 2 1 3 2 1 2 2 3 2 2 2|
Centrilobular, Necrosis | 2 2 1 1 2 4 2 3|
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Artery, Inflammation, Chronic Active | 4 3 3 |
Fat, Necrosis | 2 2 2 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 1 1 3 2 1 2 3|
Artery, Inflammation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 2|
Necrosis | 3|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Hyperplasia, Squamous | 1 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 1 2 2 1|
Artery, Inflammation | 3 |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 3 2 2 2 2 2 2 1 2 1 1 2 3 2 2 3 2 2 2 |
Necrosis | |
Atrium, Thrombosis | 3 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 5| 7| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 0| 1| 3| 9| 3| 3| 5| 3| 3| 3| 3| 2| 3| 0| 9| 3| 1| 7| 7|
| 4| 3| 3| 9| 3| 2| 8| 6| 9| 5| 3| 3| 7| 3| 3| 4| 4| 6| 4| 3| 2| 3| 3| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 2 2 2 2 2 2 2 2 1 2 2 2|
Hypertrophy | 2 2 2 2 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 1 4 4 2 3 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Hyperplasia | 4 4 2 3 2 2 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 1 1 3 3 1 1 2 1 1 2 2 1 1 2 |
Follicular Cell, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Squamous | 2|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 4 1 2 2 2 |
Inflammation, Chronic Active | 3 3 4 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Interstitial Cell, Hyperplasia | 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Iliac, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + + M + M M M + M + M M + M + M M + M + M|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + M + + + + M M + + + M + + M + + M + +|
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, | |
Polymorphonuclear | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 5| 7| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 0| 1| 3| 9| 3| 3| 5| 3| 3| 3| 3| 2| 3| 0| 9| 3| 1| 7| 7|
| 4| 3| 3| 9| 3| 2| 8| 6| 9| 5| 3| 3| 7| 3| 3| 4| 4| 6| 4| 3| 2| 3| 3| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M + M M M + M M M M M + M M M M M + M M M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 2 |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 3 2 |
Necrosis | 2 4 |
Thrombosis | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + + + M M M + M + + M + + M + M M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Inflammation, Chronic Active | 2 3 3 |
Epithelium, Hyperplasia, Basal Cell | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Artery, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Hemorrhage | 1 |
Inflammation, Chronic Active | 1 |
Inflammation, Granulomatous | 4 |
Metaplasia, Osseous | 1 |
Thrombosis | 3 |
Alveolar Epithelium, Hyperplasia | 1 3 4 1 2 1 1 1 1 2 1 2 |
Alveolar Epithelium, Metaplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 |
Bronchiole, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | 2 2 1 3 2 3 |
Thrombosis | 4 1 4 4|
Glands, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 5| 7| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 0| 1| 3| 9| 3| 3| 5| 3| 3| 3| 3| 2| 3| 0| 9| 3| 1| 7| 7|
| 4| 3| 3| 9| 3| 2| 8| 6| 9| 5| 3| 3| 7| 3| 3| 4| 4| 6| 4| 3| 2| 3| 3| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 2 1 |
Respiratory Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + A + + + + + + +|
Cataract | 2 4 3 |
Inflammation, Suppurative | |
Retina, Atrophy | 4 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 3 3|
Nephropathy | 3 2 2 1 3 1 1 3 1 1 1 2 2 2 3 2 2 2 1 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + I + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 4| 7| 7| 6| 7| | |
DAY ON TEST | 3| 6| 3| 3| 3| 1| 2| 3| 2| 3| 3| 3| 3| 6| 7| 1| 3| 6| 3| 6| 0| 3| 5| 3| | |
| 3| 0| 3| 4| 4| 5| 4| 3| 1| 3| 4| 4| 4| 0| 7| 5| 3| 0| 4| 0| 9| 3| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + A + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + A + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + A + | 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | | 1 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X | 34 |
Clear Cell Focus | X X X X X X | 14 |
Degeneration, Cystic | 2 2 | 3 2.0|
Eosinophilic Focus | X X | 3 |
Fatty Change | | 2 1.5|
Hepatodiaphragmatic Nodule | | 1 |
Mixed Cell Focus | X X | 3 |
Regeneration | 3 | 1 3.0|
Artery, Inflammation | | 1 3.0|
Bile Duct, Hyperplasia | 2 2 1 2 2 1 3 1 2 1 2 1 2 2 2 1 2 | 35 1.8|
Centrilobular, Necrosis | 2 4 1 1 3 | 13 2.2|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 13 |
Artery, Inflammation, Chronic Active | | 3 3.3|
Fat, Necrosis | 2 2 2 2 2 | 10 2.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 3 2 1 3 1 1 1 1 1 | 19 1.6|
Artery, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Metaplasia, Squamous | | 1 2.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Diverticulum | X | 1 |
Hyperplasia, Squamous | 2 | 2 1.5|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Necrosis | 3 1 | 7 1.9|
Artery, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 4| 7| 7| 6| 7| | |
DAY ON TEST | 3| 6| 3| 3| 3| 1| 2| 3| 2| 3| 3| 3| 3| 6| 7| 1| 3| 6| 3| 6| 0| 3| 5| 3| | |
| 3| 0| 3| 4| 4| 5| 4| 3| 1| 3| 4| 4| 4| 0| 7| 5| 3| 0| 4| 0| 9| 3| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 1 2 1 1 1 2 2 2 1 | 42 1.9|
Necrosis | 3 | 1 3.0|
Atrium, Thrombosis | 2 4 3 | 5 2.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | 3 | 1 3.0|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 | 30 1.9|
Hypertrophy | 2 2 1 | 7 1.9|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 2 3 2 2 3 3 2 1 3 2 2 4 3 2 | 26 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + + M + + M + + + + + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 3 4 4 3 | 11 3.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + M + A + + + + + + | 46 |
C-Cell, Hyperplasia | 2 1 1 1 3 2 3 2 2 1 1 2 2 2 1 | 32 1.6|
Follicular Cell, Hyperplasia | | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia, Squamous | | 1 2.0|
Inflammation, Chronic Active | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 3 3 2 3 3 | 11 2.4|
Inflammation, Chronic Active | | 3 3.3|
Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + A + + + + M + | 47 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 3 4 | 2 3.5|
Interstitial Cell, Hyperplasia | 1 3 1 | 5 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 4| 7| 7| 6| 7| | |
DAY ON TEST | 3| 6| 3| 3| 3| 1| 2| 3| 2| 3| 3| 3| 3| 6| 7| 1| 3| 6| 3| 6| 0| 3| 5| 3| | |
| 3| 0| 3| 4| 4| 5| 4| 3| 1| 3| 4| 4| 4| 0| 7| 5| 3| 0| 4| 0| 9| 3| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node | + + | 3 |
Iliac, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M M + + + + + + + + M + + M M + M + + + | 29 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + M + | 40 |
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + + M + + M + + + + + M M + M + + + + + + | 24 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Fibrosis | 2 2 3 3 2 | 7 2.1|
Hematopoietic Cell Proliferation | 3 2 4 | 4 3.0|
Hemorrhage | 2 | 3 2.3|
Necrosis | 4 | 3 3.3|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + + M M + I + M + + M + + M + M M + M + | 21 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + I + + + + + + + + + + + + | 48 |
Hyperkeratosis | 4 3 4 | 4 3.5|
Inflammation, Chronic Active | 3 | 4 2.8|
Epithelium, Hyperplasia, Basal Cell | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Degeneration | 2 | 1 2.0|
Artery, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Foreign Body | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 4| 7| 7| 6| 7| | |
DAY ON TEST | 3| 6| 3| 3| 3| 1| 2| 3| 2| 3| 3| 3| 3| 6| 7| 1| 3| 6| 3| 6| 0| 3| 5| 3| | |
| 3| 0| 3| 4| 4| 5| 4| 3| 1| 3| 4| 4| 4| 0| 7| 5| 3| 0| 4| 0| 9| 3| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | | 1 1.0|
Inflammation, Chronic Active | 1 | 2 1.0|
Inflammation, Granulomatous | | 1 4.0|
Metaplasia, Osseous | | 1 1.0|
Thrombosis | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 3 2 1 1 1 1 2 1 1 4 1 | 23 1.7|
Alveolar Epithelium, Metaplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 | 12 1.0|
Bronchiole, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Foreign Body | X | 1 |
Inflammation, Suppurative | 3 2 3 3 3 2 | 12 2.4|
Thrombosis | 4 4 | 6 3.5|
Glands, Hyperplasia | | 1 1.0|
Olfactory Epithelium, Atrophy | 1 1 2 | 3 1.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 3 1.3|
Respiratory Epithelium, Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cataract | 2 | 4 2.8|
Inflammation, Suppurative | 4 | 1 4.0|
Retina, Atrophy | | 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Infarct | | 3 3.0|
Nephropathy | 2 4 2 2 2 2 2 1 2 1 1 1 2 2 1 2 3 1 2 2 2 2 | 43 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 5| 5| 7| 7| 3| 6| 7| 6| 7|
DAY ON TEST | 2| 8| 3| 3| 5| 4| 3| 8| 3| 0| 8| 3| 3| 3| 8| 4| 9| 2| 3| 3| 9| 6| 3| 1| 3|
| 6| 4| 3| 3| 1| 3| 3| 4| 3| 2| 1| 3| 4| 3| 1| 3| 3| 5| 3| 4| 0| 5| 3| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X |
Degeneration, Cystic | 2 2|
Eosinophilic Focus | X |
Fatty Change | 3 |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous | |
Mixed Cell Focus | X |
Regeneration | 3 |
Bile Duct, Hyperplasia | 2 1 1 2 3 1 2 2 2 2 1 1 1 2|
Centrilobular, Necrosis | 1 2 2 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Hemorrhage | |
Fat, Inflammation | 3 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 1 2 1 3 2 2|
Basophilic Focus | X |
Hyperplasia | 2 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Ulcer | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis | 2 |
Ulcer | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + |
Inflammation, Chronic Active | 3 |
Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 5| 5| 7| 7| 3| 6| 7| 6| 7|
DAY ON TEST | 2| 8| 3| 3| 5| 4| 3| 8| 3| 0| 8| 3| 3| 3| 8| 4| 9| 2| 3| 3| 9| 6| 3| 1| 3|
| 6| 4| 3| 3| 1| 3| 3| 4| 3| 2| 1| 3| 4| 3| 1| 3| 3| 5| 3| 4| 0| 5| 3| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 2 3 3 1 3 2 2 2 2 2 2 2 2 2 3 1 1 3 1 3 2 1 1|
Atrium, Thrombosis | 2 1 |
Valve, Thrombosis, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Degeneration, Cystic | |
Hyperplasia | 1 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Hypertrophy | 3 2 2 |
Necrosis | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 3 2 3 2 1 4 |
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + M M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 3 2 4 1 3 4 2 4|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 3 1 1 1 2 2 1 1 1 1 1 4 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 2|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 |
Artery, Inflammation, Chronic Active | |
Interstitial Cell, Hyperplasia | 1 1 1 2 1 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 5| 5| 7| 7| 3| 6| 7| 6| 7|
DAY ON TEST | 2| 8| 3| 3| 5| 4| 3| 8| 3| 0| 8| 3| 3| 3| 8| 4| 9| 2| 3| 3| 9| 6| 3| 1| 3|
| 6| 4| 3| 3| 1| 3| 3| 4| 3| 2| 1| 3| 4| 3| 1| 3| 3| 5| 3| 4| 0| 5| 3| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M + M + M + + M M + + + + + + + + + M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + M + + +|
Infiltration Cellular, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + M M M M + M M M + M + + + + + + M M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 2 1 3 2|
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 4 |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + M + + + + + I + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + M + M M M M I M + M + M M M + M + M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + I + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Acute | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 |
Inflammation, Suppurative | 2 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 4 3 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 |
Bronchiole, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 1 2 2 2 2 2 1 |
Thrombosis | 2 2 1 4 |
Glands, Hyperplasia | 2 3 2 2 2 3 2 3 2 3 3 1 3 2 1 2 2 3 2 2 1 3 2 2 2|
Glands, Metaplasia, Squamous | 4|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 5| 5| 7| 7| 3| 6| 7| 6| 7|
DAY ON TEST | 2| 8| 3| 3| 5| 4| 3| 8| 3| 0| 8| 3| 3| 3| 8| 4| 9| 2| 3| 3| 9| 6| 3| 1| 3|
| 6| 4| 3| 3| 1| 3| 3| 4| 3| 2| 1| 3| 4| 3| 1| 3| 3| 5| 3| 4| 0| 5| 3| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 1 1 2 1 1 2 1 1 1 1 2 1 1 2|
Olfactory Epithelium, Atrophy | 2 2 2 2 3 2 2 3 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 2 2 1 1 2 2 2 1 2 2 1 1 2 1 2 2 1 1 2 3 4|
Olfactory Epithelium, Hyperplasia, | |
Atypical | 2 3 2 2 3 3 2 3 2 2 2 2 2 2 3 1 2 2 2 2 2 2 2 2 1|
Olfactory Epithelium, Inflammation, | |
Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 1 1 1 1 1 1|
Respiratory Epithelium, Hyperplasia | 4 2 1 1 4 2 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 1 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | M + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 4 3 1 2 2 2 3 2 2 2 3 1 2 2 1 3 2 4 3 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 4| 5| 6| 7| 6| 7| 5| 7| | |
DAY ON TEST | 8| 3| 0| 4| 3| 0| 7| 1| 3| 3| 4| 3| 3| 0| 3| 3| 3| 6| 9| 3| 7| 3| 2| 3| | |
| 0| 4| 0| 3| 3| 0| 7| 3| 4| 3| 8| 3| 3| 5| 4| 4| 5| 7| 5| 4| 8| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
10 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X | 31 |
Clear Cell Focus | X X X X X X X | 14 |
Degeneration, Cystic | 2 | 3 2.0|
Eosinophilic Focus | X | 2 |
Fatty Change | 4 | 2 3.5|
Hepatodiaphragmatic Nodule | X X X | 3 |
Inflammation, Granulomatous | 3 | 1 3.0|
Mixed Cell Focus | X | 2 |
Regeneration | 2 | 2 2.5|
Bile Duct, Hyperplasia | 2 1 3 1 2 2 2 2 1 1 1 2 2 1 3 1 2 1 | 32 1.7|
Centrilobular, Necrosis | 2 2 1 3 4 3 1 | 11 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Fat, Hemorrhage | 2 | 1 2.0|
Fat, Inflammation | | 1 3.0|
Fat, Necrosis | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 2 2 1 1 2 2 2 2 | 17 1.7|
Basophilic Focus | | 1 |
Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia, Squamous | 3 | 2 2.5|
Ulcer | 4 4 3 2 | 6 3.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Mineralization | 1 1 | 2 1.0|
Necrosis | 3 | 2 2.5|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 4| 5| 6| 7| 6| 7| 5| 7| | |
DAY ON TEST | 8| 3| 0| 4| 3| 0| 7| 1| 3| 3| 4| 3| 3| 0| 3| 3| 3| 6| 9| 3| 7| 3| 2| 3| | |
| 0| 4| 0| 3| 3| 0| 7| 3| 4| 3| 8| 3| 3| 5| 4| 4| 5| 7| 5| 4| 8| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
10 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 3.0|
Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cardiomyopathy | 1 2 2 2 3 2 2 2 1 2 1 1 2 1 2 2 2 1 1 3 | 44 1.9|
Atrium, Thrombosis | | 2 1.5|
Valve, Thrombosis, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | 3 | 1 3.0|
Degeneration, Cystic | 3 2 | 2 2.5|
Hyperplasia | 2 1 2 2 3 1 2 2 2 2 2 2 | 28 2.0|
Hypertrophy | 2 2 2 | 6 2.2|
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 2 2 4 2 2 | 13 2.6|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + + + + + + + + M + + + + + + + M + | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cyst | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 4 2 3 | 12 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + | 47 |
C-Cell, Hyperplasia | 1 1 1 2 1 1 3 1 1 1 1 2 1 1 2 2 2 1 2 | 36 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | 3 | 1 3.0|
Granuloma Sperm | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 3 3 2 1 1 | 8 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 4| 5| 6| 7| 6| 7| 5| 7| | |
DAY ON TEST | 8| 3| 0| 4| 3| 0| 7| 1| 3| 3| 4| 3| 3| 0| 3| 3| 3| 6| 9| 3| 7| 3| 2| 3| | |
| 0| 4| 0| 3| 3| 0| 7| 3| 4| 3| 8| 3| 3| 5| 4| 4| 5| 7| 5| 4| 8| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
10 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 4 | 2 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 3 | 4 3.5|
Artery, Inflammation, Chronic Active | 2 2 | 2 2.0|
Interstitial Cell, Hyperplasia | 2 1 | 9 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + M + M + M + M + + + + M + + + + | 36 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + M + + + + | 45 |
Infiltration Cellular, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M + M M + M + M + + + M M + + + M + M + + | 28 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Fibrosis | 3 2 2 3 2 | 12 2.2|
Hematopoietic Cell Proliferation | 3 2 | 3 2.7|
Hemorrhage | | 1 4.0|
Necrosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M + M M M M + + + + M M M + M + M + M M + | 20 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperkeratosis | 4 4 | 2 4.0|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 4| 5| 6| 7| 6| 7| 5| 7| | |
DAY ON TEST | 8| 3| 0| 4| 3| 0| 7| 1| 3| 3| 4| 3| 3| 0| 3| 3| 3| 6| 9| 3| 7| 3| 2| 3| | |
| 0| 4| 0| 3| 3| 0| 7| 3| 4| 3| 8| 3| 3| 5| 4| 4| 5| 7| 5| 4| 8| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
10 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cyst, Squamous | 2 | 1 2.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 | 13 1.0|
Inflammation, Suppurative | | 1 2.0|
Thrombosis | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 1 2 3 2 | 12 1.9|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 | 9 1.0|
Bronchiole, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Suppurative | 1 1 2 2 2 1 2 1 2 | 18 1.7|
Thrombosis | 4 4 4 | 7 3.0|
Glands, Hyperplasia | 3 1 2 2 2 2 2 2 2 3 3 2 2 1 2 3 2 2 2 2 2 3 2 2 | 49 2.2|
Glands, Metaplasia, Squamous | 4 1 | 3 3.0|
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 1 2 1 2 2 1 1 1 1 1 2 | 25 1.3|
Olfactory Epithelium, Atrophy | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 3 | 49 2.1|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 2 1 3 3 3 2 1 2 1 2 2 1 1 2 2 2 2 1 | 46 1.7|
Olfactory Epithelium, Hyperplasia, | | |
Atypical | 3 2 2 2 2 2 2 2 2 2 2 1 3 2 3 2 2 3 2 2 4 2 1 | 48 2.1|
Olfactory Epithelium, Inflammation, | | |
Chronic | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 49 2.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 2 1 1 1 1 1 1 1 1 1 2 | 20 1.2|
Respiratory Epithelium, Hyperplasia | 3 1 1 3 4 4 1 4 1 2 2 3 | 21 2.2|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 3 2 2 2 2 1 2 2 2 3 | 15 2.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cataract | 3 2 | 2 2.5|
Retina, Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Nephropathy | 2 2 2 1 3 2 2 2 3 2 1 4 2 3 3 1 3 1 2 2 4 | 44 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 4| 5| 6| 7| 6| 7| 5| 7| | |
DAY ON TEST | 8| 3| 0| 4| 3| 0| 7| 1| 3| 3| 4| 3| 3| 0| 3| 3| 3| 6| 9| 3| 7| 3| 2| 3| | |
| 0| 4| 0| 3| 3| 0| 7| 3| 4| 3| 8| 3| 3| 5| 4| 4| 5| 7| 5| 4| 8| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
10 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 6| 7| 7| 6| 7| 5| 0| 7| 7| 7| 4| 6| 6| 7| 7| 7| 5| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 8| 6| 8| 1| 3| 1| 3| 4| 2| 3| 3| 3| 8| 3| 6| 3| 3| 3| 8| 2| 0| 2|
| 3| 3| 3| 5| 0| 1| 0| 4| 3| 4| 7| 9| 3| 4| 4| 9| 0| 3| 4| 3| 4| 2| 8| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + I + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + A + + + + + + A + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X |
Clear Cell Focus | X X X X X |
Degeneration, Cystic | |
Eosinophilic Focus | X |
Fatty Change | 2 1 |
Hepatodiaphragmatic Nodule | |
Mixed Cell Focus | |
Necrosis | |
Regeneration | |
Tension Lipidosis | X |
Bile Duct, Hyperplasia | 1 2 2 2 3 2 1 2 1 1 2 2 3 3 3 2|
Centrilobular, Necrosis | 1 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Artery, Mineralization | |
Fat, Necrosis | 2 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 1 4 1 1 2|
Basophilic Focus | |
Hyperplasia | 2 2 |
Artery, Inflammation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 2 |
Inflammation, Acute | |
Ulcer | 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Mineralization | |
Necrosis | |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 6| 7| 7| 6| 7| 5| 0| 7| 7| 7| 4| 6| 6| 7| 7| 7| 5| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 8| 6| 8| 1| 3| 1| 3| 4| 2| 3| 3| 3| 8| 3| 6| 3| 3| 3| 8| 2| 0| 2|
| 3| 3| 3| 5| 0| 1| 0| 4| 3| 4| 7| 9| 3| 4| 4| 9| 0| 3| 4| 3| 4| 2| 8| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 |
Hypertrophy | 2 2 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 3 2 2 3 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + M + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 3 2 4 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + M + + + + + + + + + + + + + + M + + + +|
C-Cell, Hyperplasia | 1 1 1 2 2 1 2 1 2 3 1 1 1 1 2|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation, Chronic Active | 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 4 1 2 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Interstitial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M M M + + + + + M + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 6| 7| 7| 6| 7| 5| 0| 7| 7| 7| 4| 6| 6| 7| 7| 7| 5| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 8| 6| 8| 1| 3| 1| 3| 4| 2| 3| 3| 3| 8| 3| 6| 3| 3| 3| 8| 2| 0| 2|
| 3| 3| 3| 5| 0| 1| 0| 4| 3| 4| 7| 9| 3| 4| 4| 9| 0| 3| 4| 3| 4| 2| 8| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + M + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 4 |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + M + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + + M + + M M + M + + M M + + + + + + M M|
Galactocele | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hyperplasia, Basal Cell | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 |
Alveolar Epithelium, Hyperplasia | 2 2 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 2 2 2 2 1 1 1 2 2 |
Thrombosis | 1 4 4 |
Glands, Hyperplasia | 3 3 3 2 2 3 3 3 3 3 3 3 3 3 2 4 3 3 3 3 3 3 2 2|
Glands, Metaplasia, Squamous | 3 2 1 3 2 |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 1 1 2 1 1 2 2 2 1 1 1 1 1 2|
Olfactory Epithelium, Atrophy | 2 3 3 3 2 3 3 2 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 2|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 2 1 1 1 1 1 3 1 1 3 2 3 2 3 2 3 2 2 1|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 6| 7| 7| 6| 7| 5| 0| 7| 7| 7| 4| 6| 6| 7| 7| 7| 5| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 8| 6| 8| 1| 3| 1| 3| 4| 2| 3| 3| 3| 8| 3| 6| 3| 3| 3| 8| 2| 0| 2|
| 3| 3| 3| 5| 0| 1| 0| 4| 3| 4| 7| 9| 3| 4| 4| 9| 0| 3| 4| 3| 4| 2| 8| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Olfactory Epithelium, Hyperplasia, | |
Atypical | 2 3 2 2 1 2 3 3 2 2 3 2 3 2 2 3 2 3 3 3 1 3 3 2|
Olfactory Epithelium, Inflammation, | |
Chronic | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 3 2 3 2 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 2 1 1 2 1 2 1|
Respiratory Epithelium, Hyperplasia | 2 2 1 2 1 3 1 4 1 2 2 2 3 2 3|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 2 3 3 1 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Metaplasia, Osseous | 2 |
Nephropathy | 3 2 1 1 2 1 3 1 2 1 2 2 2 1 1 2 2 2 2 1 2 1 1|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7| | |
DAY ON TEST | 4| 3| 5| 3| 6| 8| 1| 0| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3| 3| 3| 8| 7| 3| | |
| 3| 3| 0| 4| 3| 5| 5| 7| 3| 4| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 1| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + | 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | | 1 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X X | 28 |
Clear Cell Focus | X X X X X X X X X | 14 |
Degeneration, Cystic | 2 2 | 2 2.0|
Eosinophilic Focus | | 1 |
Fatty Change | 3 2 | 4 2.0|
Hepatodiaphragmatic Nodule | X X | 2 |
Mixed Cell Focus | X X | 2 |
Necrosis | 2 | 1 2.0|
Regeneration | 2 | 1 2.0|
Tension Lipidosis | | 1 |
Bile Duct, Hyperplasia | 3 2 3 3 1 1 2 2 1 1 3 2 | 28 2.0|
Centrilobular, Necrosis | 1 1 1 1 2 | 7 1.4|
__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Artery, Mineralization | 3 | 1 3.0|
Fat, Necrosis | 2 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 2 3 2 2 1 2 3 2 1 | 17 1.8|
Basophilic Focus | X | 1 |
Hyperplasia | | 2 2.0|
Artery, Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia, Squamous | | 2 2.0|
Inflammation, Acute | 4 | 1 4.0|
Ulcer | 4 | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Acute | 4 | 1 4.0|
Mineralization | 1 | 1 1.0|
Necrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7| | |
DAY ON TEST | 4| 3| 5| 3| 6| 8| 1| 0| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3| 3| 3| 8| 7| 3| | |
| 3| 3| 0| 4| 3| 5| 5| 7| 3| 4| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 1| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
Inflammation, Chronic Active | 3 3 3 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cardiomyopathy | 3 2 2 2 2 1 3 1 1 2 2 2 2 2 2 2 2 2 1 1 2 | 37 1.9|
Atrium, Thrombosis | 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Degeneration, Cystic | | 1 2.0|
Hyperplasia | 2 2 2 2 2 2 2 1 2 2 2 1 2 | 23 1.9|
Hypertrophy | 2 2 2 2 1 2 | 9 1.9|
Necrosis | 3 | 2 2.5|
Vacuolization Cytoplasmic | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | 2 3 3 1 3 2 2 2 2 2 2 2 | 23 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M M + + + + M + + + + + + + | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Pars Distalis, Hyperplasia | 1 3 3 2 2 | 10 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + | 45 |
C-Cell, Hyperplasia | 2 1 1 1 1 1 2 2 1 2 1 1 2 1 2 3 | 31 1.5|
Follicular Cell, Hyperplasia | 1 3 | 3 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + M + + + + + + + | 47 |
Cyst | | 1 3.0|
Inflammation, Chronic Active | 3 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 4 3 3 1 1 2 1 2 2 2 | 16 2.2|
Inflammation, Chronic Active | 3 3 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7| | |
DAY ON TEST | 4| 3| 5| 3| 6| 8| 1| 0| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3| 3| 3| 8| 7| 3| | |
| 3| 3| 0| 4| 3| 5| 5| 7| 3| 4| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 1| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 4 4 | 2 4.0|
Interstitial Cell, Hyperplasia | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + M M M + + + + + M + + + + + + + + | 38 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Infiltration Cellular, Plasma Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + M + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Fibrosis | 1 2 1 2 2 | 6 1.7|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hemorrhage | 3 | 2 3.5|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + M + + + + + + + + + + + + | 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + + M M + + M M + + M M + + | 30 |
Galactocele | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cyst Epithelial Inclusion | | 1 |
Hyperplasia, Basal Cell | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Osteopetrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Degeneration | | 1 2.0|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Metaplasia, Squamous | 2 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7| | |
DAY ON TEST | 4| 3| 5| 3| 6| 8| 1| 0| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3| 3| 3| 8| 7| 3| | |
| 3| 3| 0| 4| 3| 5| 5| 7| 3| 4| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 1| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Chronic Active | 1 1 1 | 6 1.0|
Alveolar Epithelium, Hyperplasia | 3 1 1 1 1 | 9 1.6|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | 2 2 2 2 1 | 16 1.8|
Thrombosis | 4 1 3 | 6 2.8|
Glands, Hyperplasia | 3 2 2 4 2 3 3 3 2 4 4 2 2 4 3 3 3 3 3 3 3 3 3 3 | 48 2.9|
Glands, Metaplasia, Squamous | 1 2 2 4 2 2 2 2 2 | 14 2.1|
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 | 29 1.2|
Olfactory Epithelium, Atrophy | 3 3 3 3 3 2 3 3 3 3 3 3 2 3 3 3 2 3 3 4 3 3 2 3 | 48 2.8|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 2 1 3 2 2 2 1 2 3 1 2 1 1 1 3 | 40 1.7|
Olfactory Epithelium, Hyperplasia, | | |
Atypical | 3 2 3 2 3 2 3 3 2 3 3 2 4 2 2 2 3 2 3 3 3 | 45 2.5|
Olfactory Epithelium, Inflammation, | | |
Chronic | 2 2 2 2 2 2 3 3 2 2 2 2 2 3 2 3 2 2 3 2 2 2 2 2 | 48 2.2|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 2 2 1 2 2 1 | 19 1.4|
Respiratory Epithelium, Hyperplasia | 2 4 1 2 2 4 2 2 1 2 2 2 1 1 | 29 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 3 1 2 2 3 2 2 2 3 1 2 2 2 2 2 | 23 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cataract | 2 | 1 2.0|
Retina, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infarct | | 1 2.0|
Metaplasia, Osseous | | 1 2.0|
Nephropathy | 1 3 4 2 1 3 3 2 1 2 1 2 1 2 2 2 1 3 2 1 1 1 | 45 1.8|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7| | |
DAY ON TEST | 4| 3| 5| 3| 6| 8| 1| 0| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3| 3| 3| 8| 7| 3| | |
| 3| 3| 0| 4| 3| 5| 5| 7| 3| 4| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 1| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 2| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 6| 3| 1| 8| 3| 5| 6| 3| 2| 7| 2| 3| 4| 6| 3| 3| 8| 3| 3| 3| 3| 3| 9|
| 3| 3| 0| 2| 2| 5| 4| 9| 0| 3| 2| 1| 4| 3| 5| 9| 4| 3| 5| 4| 4| 4| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
60 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + I + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X |
Degeneration, Cystic | |
Eosinophilic Focus | X |
Fatty Change | 1 1 |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X X |
Regeneration | |
Syncytial Alteration | |
Bile Duct, Hyperplasia | 2 2 2 1 3 1 1 1 2 2 1 |
Centrilobular, Necrosis | 2 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Artery, Inflammation, Chronic Active | |
Fat, Necrosis | 2 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 1 2 2 2 2 |
Basophilic Focus | |
Hyperplasia | 3 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Necrosis | 1 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 |
Ulcer | 3 |
__________________________________________________________________________|
Tooth | + + |
Malformation | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 2 3 1 2 3 2 1 2 3 2 3 1 2 3 3 2 2 1|
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 2| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 6| 3| 1| 8| 3| 5| 6| 3| 2| 7| 2| 3| 4| 6| 3| 3| 8| 3| 3| 3| 3| 3| 9|
| 3| 3| 0| 2| 2| 5| 4| 9| 0| 3| 2| 1| 4| 3| 5| 9| 4| 3| 5| 4| 4| 4| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
60 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 4 |
Hyperplasia | 2 2 2 2 2 1 2 2 2 1 2 2 2 1 2 2 2 |
Hypertrophy | 2 2 |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 1 1 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + M + + + + M + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Pars Distalis, Hyperplasia | 3 4 3 3 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 1 1 2 1 1 1 2 2 2 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + A + + + I + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Artery, Inflammation, Chronic Active | 3 |
Interstitial Cell, Hyperplasia | 1 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + M + + + + M M + + + M + + + M + M|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + M + + + + + + + M +|
Infiltration Cellular, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 2| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 6| 3| 1| 8| 3| 5| 6| 3| 2| 7| 2| 3| 4| 6| 3| 3| 8| 3| 3| 3| 3| 3| 9|
| 3| 3| 0| 2| 2| 5| 4| 9| 0| 3| 2| 1| 4| 3| 5| 9| 4| 3| 5| 4| 4| 4| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
60 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 2 2 1 2 |
Hematopoietic Cell Proliferation | 3 2 |
Hemorrhage | 3 |
Necrosis | 2 |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + + + + + + M + + + M + + M + + M M + M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 |
Inflammation, Granulomatous | |
Alveolar Epithelium, Hyperplasia | 1 1 2 1 1 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Suppurative | 3 2 2 2 2 2 2 2 |
Thrombosis | 3 |
Glands, Hyperplasia | 4 3 3 4 4 3 4 4 4 4 4 3 4 3 3 3 3 3 4 4 3 4 3 3|
Glands, Metaplasia, Squamous | 2 1 3 2 3 3 4 3 3 2 2 2 |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 2 1 1 1 1 1 2 1 1 2 1 1 1 1 1 |
Olfactory Epithelium, Atrophy | 3 3 3 4 4 4 4 3 3 3 4 4 4 3 3 3 3 4 3 4 4 4 3|
Olfactory Epithelium, Degeneration, | |
Hyaline | 3 1 1 1 2 1 1 1 2 1 2 3 1 3 2 1 2 2 1 2 1|
Olfactory Epithelium, Hyperplasia, | |
Atypical | 3 3 3 3 2 3 2 3 4 3 3 3 2 2 2 2 4 3 4 3 3 3 2|
Olfactory Epithelium, Inflammation, | |
Chronic | 3 3 3 3 2 2 3 3 2 3 3 3 3 3 2 3 3 2 3 3 3 3 4 3|
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 2 1 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 2| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 6| 3| 1| 8| 3| 5| 6| 3| 2| 7| 2| 3| 4| 6| 3| 3| 8| 3| 3| 3| 3| 3| 9|
| 3| 3| 0| 2| 2| 5| 4| 9| 0| 3| 2| 1| 4| 3| 5| 9| 4| 3| 5| 4| 4| 4| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
60 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Hyperplasia | 2 3 1 1 3 2 1 2 1 3 3|
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 2 2 2 2 2 4 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 1 |
Hemorrhage | |
Retina, Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Inflammation, Suppurative | |
Nephropathy | 2 3 4 1 1 2 2 3 1 2 2 3 2 1 2 2 1 2 1 1 3 2 |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 3| 5| 7| 7| 6| 7| 7| 5| 7| 7| 5| 5| 7| 5| 5| 7| 6| 6| 6| 7| | |
DAY ON TEST | 0| 3| 6| 1| 9| 2| 3| 3| 5| 0| 3| 3| 3| 3| 5| 7| 3| 7| 2| 3| 0| 3| 0| 3| | |
| 3| 3| 2| 9| 9| 6| 4| 4| 7| 7| 4| 9| 3| 3| 2| 2| 3| 5| 7| 3| 0| 9| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
60 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Basophilic Focus | X X X X X X X X X X X X | 32 |
Clear Cell Focus | X X X X X X | 11 |
Degeneration, Cystic | 3 1 | 2 2.0|
Eosinophilic Focus | X | 2 |
Fatty Change | 2 3 2 | 5 1.8|
Hepatodiaphragmatic Nodule | X | 2 |
Mixed Cell Focus | | 2 |
Regeneration | 2 | 1 2.0|
Syncytial Alteration | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 1 3 2 2 1 2 1 2 2 | 21 1.7|
Centrilobular, Necrosis | 1 3 | 4 1.8|
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Artery, Inflammation, Chronic Active | 2 | 1 2.0|
Fat, Necrosis | 2 3 | 6 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 2 1 1 2 1 1 | 14 1.6|
Basophilic Focus | X | 1 |
Hyperplasia | | 1 3.0|
Duct, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia, Squamous | 2 | 1 2.0|
Necrosis | | 1 1.0|
Ulcer | 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Necrosis | 2 2 | 3 1.7|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Malformation | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 3| 5| 7| 7| 6| 7| 7| 5| 7| 7| 5| 5| 7| 5| 5| 7| 6| 6| 6| 7| | |
DAY ON TEST | 0| 3| 6| 1| 9| 2| 3| 3| 5| 0| 3| 3| 3| 3| 5| 7| 3| 7| 2| 3| 0| 3| 0| 3| | |
| 3| 3| 2| 9| 9| 6| 4| 4| 7| 7| 4| 9| 3| 3| 2| 2| 3| 5| 7| 3| 0| 9| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
60 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cardiomyopathy | 2 2 2 1 1 2 1 2 3 1 1 2 1 1 1 3 1 2 3 2 | 42 1.9|
Atrium, Thrombosis | 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Degeneration, Cystic | | 1 4.0|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 3 2 2 1 2 2 2 2 2 | 36 1.9|
Hypertrophy | 2 3 | 4 2.3|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 2 4 2 2 4 | 12 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | 3 | 1 3.0|
Cyst | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 1 3 4 3 3 2 3 3 2 | 15 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + I + + + + + + + + + + | 47 |
C-Cell, Hyperplasia | 1 1 1 3 1 1 1 3 1 1 1 1 1 2 1 3 1 1 | 33 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cyst | | 1 4.0|
Inflammation, Chronic Active | 2 | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 2 1 1 2 | 8 1.8|
Inflammation, Chronic Active | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 4 3 3 3 | 4 3.3|
Artery, Inflammation, Chronic Active | 3 | 2 3.0|
Interstitial Cell, Hyperplasia | 2 1 1 1 1 1 1 | 11 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 3| 5| 7| 7| 6| 7| 7| 5| 7| 7| 5| 5| 7| 5| 5| 7| 6| 6| 6| 7| | |
DAY ON TEST | 0| 3| 6| 1| 9| 2| 3| 3| 5| 0| 3| 3| 3| 3| 5| 7| 3| 7| 2| 3| 0| 3| 0| 3| | |
| 3| 3| 2| 9| 9| 6| 4| 4| 7| 7| 4| 9| 3| 3| 2| 2| 3| 5| 7| 3| 0| 9| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
60 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + + + + + + + + M + M + + M + M M M | 35 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + M + + + + | 44 |
Infiltration Cellular, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + + + + + + + + + M + M + + M + M M + | 41 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Fibrosis | 2 2 | 6 1.8|
Hematopoietic Cell Proliferation | 2 3 | 4 2.5|
Hemorrhage | 4 | 2 3.5|
Necrosis | 2 | 2 2.0|
Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + + + + + + + + M + + | 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M M + M + + + M + M M M M M + M + M M | 28 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + I + + + + + + + + + + + + + + + | 48 |
Hyperkeratosis | 2 | 1 2.0|
Hyperplasia, Squamous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Foreign Body | X | 1 |
Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 | 15 1.1|
Inflammation, Granulomatous | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 2 4 1 1 1 2 1 | 16 1.4|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 3 1 | 15 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05110-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:08:03
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 3| 5| 7| 7| 6| 7| 7| 5| 7| 7| 5| 5| 7| 5| 5| 7| 6| 6| 6| 7| | |
DAY ON TEST | 0| 3| 6| 1| 9| 2| 3| 3| 5| 0| 3| 3| 3| 3| 5| 7| 3| 7| 2| 3| 0| 3| 0| 3| | |
| 3| 3| 2| 9| 9| 6| 4| 4| 7| 7| 4| 9| 3| 3| 2| 2| 3| 5| 7| 3| 0| 9| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
60 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 1 | 9 2.0|
Thrombosis | 4 4 | 3 3.7|
Glands, Hyperplasia | 3 3 4 4 2 4 4 4 3 3 4 4 4 4 4 4 3 3 3 4 4 3 4 3 | 48 3.5|
Glands, Metaplasia, Squamous | 4 2 3 2 2 4 4 3 1 2 2 2 2 3 | 26 2.5|
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 2 2 1 1 1 1 1 1 1 2 1 | 26 1.2|
Olfactory Epithelium, Atrophy | 4 4 3 3 4 3 4 3 3 4 4 3 4 4 4 3 3 3 4 3 3 3 3 4 | 47 3.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 1 1 2 2 1 2 1 1 2 2 1 1 1 1 2 1 | 38 1.5|
Olfactory Epithelium, Hyperplasia, | | |
Atypical | 3 3 3 3 4 4 3 3 3 2 4 3 3 3 4 3 2 3 4 3 3 3 3 | 46 3.0|
Olfactory Epithelium, Inflammation, | | |
Chronic | 3 4 3 3 3 3 4 3 3 3 3 3 4 3 3 3 3 2 3 4 3 4 3 3 | 48 3.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 1 2 2 1 1 | 19 1.2|
Respiratory Epithelium, Hyperplasia | 3 2 1 2 1 2 2 4 4 1 1 2 3 4 2 2 3 2 | 29 2.2|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 1 1 2 1 2 2 1 2 | 18 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cataract | 2 3 | 3 2.0|
Hemorrhage | 4 | 1 4.0|
Retina, Atrophy | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Infarct | 2 3 | 3 2.3|
Inflammation, Suppurative | 4 | 1 4.0|
Nephropathy | 3 2 2 1 1 1 2 2 3 3 1 4 2 2 1 2 1 2 2 1 3 | 43 2.0|
Renal Tubule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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---------- END OF REPORT ----------
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